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Theses and Dissertations

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Lucky Strike Branch Library, Vanessa Yvonne Vinsant Jan 2008

Lucky Strike Branch Library, Vanessa Yvonne Vinsant

Theses and Dissertations

This thesis project is an examination of how design can reinvigorate interest in reading through the creation of a branch library. The primary focus of this study is to generate a space that successfully binds intellectual interests, social and economic groups to re-establish community.


Virginia Emergency Department Physician Knowledge Of The Emergent Treatment Of Avulsed Teeth, Joy Leatrice Barnes Phelps Jan 2008

Virginia Emergency Department Physician Knowledge Of The Emergent Treatment Of Avulsed Teeth, Joy Leatrice Barnes Phelps

Theses and Dissertations

Purpose: The purpose of this study was to determine the knowledge and treatment protocols for physicians in Virginia emergency departments in regards to the emergent treatment of avulsed teeth.Methods: Using a cross sectional survey design, an 8-item questionnaire regarding the treatment of avulsed teeth was emailed to 75 emergency department chairpersons in Virginia. After 30 days, a reminder paper copy of the questionnaire was mailed and an email reminder with the on-line link was sent. After 60 days the study was closed. Comparisons were made using chi-square analysis based on percentages to test for significance. Results: The response rate was …


Alternative Orthodontic Bonding Protocol Using Self Etching Primer, Rush-Baker Gaines Caldwell Jan 2008

Alternative Orthodontic Bonding Protocol Using Self Etching Primer, Rush-Baker Gaines Caldwell

Theses and Dissertations

The purpose of the current study was to develop a bonding method that can achieve clinically acceptable bond strength values while leaving a minimum amount of adhesive on the tooth surface during the debonding process. One hundred teeth were randomly assigned into groups. Five different enamel surface preparation protocols were tested (N = 20, each): Conventional acid etch, standard SEP, SEP applied with a light brush stroke (altered SEP 1), SEP applied directly to the composite of pre-coated bracket (altered SEP 2), and Primer Only groups. Brackets were debonded using an Instron universal testing machine (Instron, Canton, MA) in shear …


Endocannabinoid Modulation Of Spatial Memory In Aversively And Appetitively Motivated Barnes Maze Tasks, John Pinckney Harloe Jan 2008

Endocannabinoid Modulation Of Spatial Memory In Aversively And Appetitively Motivated Barnes Maze Tasks, John Pinckney Harloe

Theses and Dissertations

Genetic deletion or pharmacological blockade of the CB1 receptor has been reported to impair extinction learning in aversive conditioning (i.e., conditioned fear and Morris water maze) paradigms, but not in operant procedures in which food reinforcement is earned. It is difficult to discern whether the differential effects caused by CB1 receptor disruption on extinction result from the hedonics (i.e., aversive vs. appetitive) or is related to the required responses associated with these disparate tasks. In order to evaluate whether the hedonics is the determining factor, we used either aversive (i.e., escape from bright lights and air turbulence) or appetitive (i.e., …


Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar Jan 2008

Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar

Theses and Dissertations

The purpose of this investigation was to evaluate the effects of smoking and gender on 1) tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) in a population of healthy subjects and 2) TIQs in an alcohol-dependent population undergoing in-patient detoxification. Comparison in plasma TIQs between the populations was additionally conducted. To support the clinical investigations, a HPLC-FD method was developed and validated to assess plasma concentrations of BCs, harman and norharman, while a HPLC-ESI-MS/MS method was validated to quantify the TIQs, R/S-salsolinol along with dopamine. Forty-one young volunteers were recruited including 19 nonsmokers (NS), 11 light smokers (LS) and 11 heavy smokers (HS), …


Characterization Of Yeast 18s Rrna Dimethyl Transferase, Dim1p, Nagesh Pulicherla Jan 2008

Characterization Of Yeast 18s Rrna Dimethyl Transferase, Dim1p, Nagesh Pulicherla

Theses and Dissertations

Eukaryotic ribosome biogenesis, a dynamic and coordinated multistep process which requires more than 150 trans-acting factors, has been intensely studied in the yeast Saccharomyces cerevisiae. This evolutionarily conserved process involves numerous cleavages of pre-rRNA, modification of nucleotides, and concomitant assembly of the ribosomal proteins onto the rRNA. Considerable information is available about the importance of conserved pre-rRNA cleavage events in ribosome biogenesis; however, very little is known about the exact role of modified nucleotides, which cluster within the functionally important regions of the ribosome. One conserved group of modifications is the dimethylation of two adjacent adenosines at the 3´ end …


Density Of Gutta Percha By Weight In Straight Root Canals And Curved Root Canals After Single Cone, Cold Lateral, And Warm Vertical Condensation, Gerald Clay Sparrow Jan 2008

Density Of Gutta Percha By Weight In Straight Root Canals And Curved Root Canals After Single Cone, Cold Lateral, And Warm Vertical Condensation, Gerald Clay Sparrow

Theses and Dissertations

The purpose of this study was to compare the density of gutta percha following three different obturation techniques using two split-tooth models. One split-tooth model was constructed with a straight rooted maxillary incisor and the other with the curved palatal root of a maxillary molar. Each tooth was obturated using single cone, cold lateral, and warm vertical obturation techniques without sealer. Each obturation technique was performed 20 times for each of the root systems. The weights of the gutta percha were recorded for each root type and obturation technique by subtracting the post-fill weight from the pre-fill weight of the …


Evaluation Of An Early Discharge Policy For Infants With Apnea Of Prematurity, Cheryl N. Bodamer Jan 2008

Evaluation Of An Early Discharge Policy For Infants With Apnea Of Prematurity, Cheryl N. Bodamer

Theses and Dissertations

This research examines the safety and cost effectiveness of an institutional policy on discharge of preterm infants with Apnea of Prematurity (AOP) from the Virginia Commonwealth University Medical Center Newborn Intensive Care Unit (VCUNC NICU) with caffeine therapy and a cardiorespiratory monitor. This practice policy was developed over a decade ago as a cost containment measure in neonatal care and continues to be implemented today despite the lack of a formal evaluation. The secondary objective was to examine through a review of the literature the psychosocial impact of premature birth on the family and the potential effect on the infant's …


Examining The Behavioral And Molecular Aspects Of Adolescent Nicotine Dependence: Implications For Vulnerability To Drugs Of Abuse, Dena Heath Kota Jan 2008

Examining The Behavioral And Molecular Aspects Of Adolescent Nicotine Dependence: Implications For Vulnerability To Drugs Of Abuse, Dena Heath Kota

Theses and Dissertations

Approximately 200 million men and 100 million women smoke worldwide. In the United States, an estimated 25.9 million men (23.9 percent) and 20.7 million women (18.1 percent) are smokers. The commencement of smoking at a young age is thought to increase addiction liability, decrease the probability of successful cessation, and correlate with a higher number of cigarettes smoked per day. Studies from the World Health Organization indicate that between 80,000 and 100,000 children start smoking every day worldwide. These statistics suggest that adolescence is a critical phase for developing nicotine dependence. The work in this dissertation contributes to the further …


5-Ht3 Receptor Ligands And Their Effect On Psychomotor Stimulants, Jessica Nicole Worsham Jan 2008

5-Ht3 Receptor Ligands And Their Effect On Psychomotor Stimulants, Jessica Nicole Worsham

Theses and Dissertations

Drug abuse and addiction are considered to be a result, at least in part, of the rewarding effects produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity assays to determine whether MD-354 is working through a 5-HT3 receptor agonist or antagonist mode of action. Studies with (+)amphetamine and (+)methamphetamine in combination with MD-354 indicated MD-354 is either devoid of action or is behaving similar to the 5-HT3 receptor antagonist, ondansetron. This …


The Psychosocial Influence Of Dental Esthetics In Adolescents As Judged By Peers, Scott Thomas Henson Jan 2008

The Psychosocial Influence Of Dental Esthetics In Adolescents As Judged By Peers, Scott Thomas Henson

Theses and Dissertations

The purpose of this study was to determine if dental esthetics affects the perception of adolescents regarding their peer's social aptitude in specific areas such as athletics, popularity, leadership, and academics. Ten patient photographs (4 males, 6 females) from a private orthodontic practice in Richmond, VA were selected for inclusion in this study. The frontal smiling photographs were digitally modified with insertion of either an ideal smile (straight) or a non-ideal smile (crooked) to create an image identical to the original except for an altered dental complex. Laypersons rated the straight and crooked patient photographs for athletic performance, socialization skills …


In Pursuit Of Paternal Significance: Fathers' Influence On Their Daughters' And Sons' Sexual Behaviors And Beliefs, Rachel S. Everley Jan 2008

In Pursuit Of Paternal Significance: Fathers' Influence On Their Daughters' And Sons' Sexual Behaviors And Beliefs, Rachel S. Everley

Theses and Dissertations

The United States has the highest teen pregnancy and adolescent STD rates of any industrialized nation. Numerous factors are involved in adolescent sexual decision-making and the social-ecological framework suggests that there are multiple levels of influence on adolescent development, including familial. Utilizing survey data from the Virginia Abstinence Education Initiative (VAEI), this project specifically explores paternal influences on adolescent sexual behavior and beliefs by examining paternal residence in the home, perceived paternal figure sexual beliefs, and father-child relationship factors. Results indicate that paternal figures influence their daughters' and sons' sexual behaviors as well as beliefs. Differences in paternal figure influence …


Characterization Of Microorganisms Of Interest To Homeland Security And Public Health Utilizing Liquid Chromatography/Mass Spectrometry, Robert A. Everley Jan 2008

Characterization Of Microorganisms Of Interest To Homeland Security And Public Health Utilizing Liquid Chromatography/Mass Spectrometry, Robert A. Everley

Theses and Dissertations

Liquid chromatography/quadrupole time of flight mass spectrometry (LC/QTOF MS) utilizing electrospray ionization was employed to monitor protein expression in Escherichia coli and Shigella organisms. Automated charge state deconvolution, spectral subtraction and spectral mirroring were used to reveal subtle differences in the LC/MS data. Reproducible intact protein biomarkers were discovered based on their unique mass, retention time and relative intensity. These markers were implemented to differentiate closely related strain types, (e.g. two distinct isolates of E. coli O157:H7) and to correctly identify unknown pathogens. Notable, was the distinction of multiple serotypes of enterohaemorrhagic E. coli which cannot be distinguished by clinical …


Inflammation-Associated Gene Regulation In Primary Astrocytes, Glial Tumors And Cellular Differentiation, Katarzyna Marta Wilczynska Jan 2008

Inflammation-Associated Gene Regulation In Primary Astrocytes, Glial Tumors And Cellular Differentiation, Katarzyna Marta Wilczynska

Theses and Dissertations

This dissertation elucidates several independent molecular mechanisms that function in astrocytes and glial tumor cells, and suggest that developmental and inflammatory signals may contribute to the development of brain tumors. First, we analyzed the mechanism of TIMP-1 activation in astrocytes and glioblastoma cells. TIMP-1 expression is activated by IL-1, which is the major neuroinflammatory cytokine, via simultaneous activation of IKK/NF-kB and MEK3/6/p38/ATF-2 pathways in primary human astrocytes. In contrast to astrocytes, TIMP-1 is expressed at lower levels in glioblastomas, and is not regulated by IL-1 due to either dysfunctional IKK/NF-kB or MEK3/6/p38/ATF-2 activation. Thus, we propose a novel mechanism of …


Grace Street Senior Center, Virginia Brockett Jan 2008

Grace Street Senior Center, Virginia Brockett

Theses and Dissertations

Societal structure has changed through the decades to reflect a contemporary interest in youth culture. The nuclear family, where generations lived under one roof no longer exists, leaving the elderly on the periphery of the family structure. Where once grandparents, parents and children all cohabitated, now the oldest family members are relegated to solitary retirement and aging alone. Studies have shown that "depression in the elderly is more likely to lead to suicide. Elderlywhite men are at greatest risk, with suicide rates in people ages 80 to 84 more than twice that of the general population. The National Institute of …


Fluoride Varnish Use Among Dentists In Virginia, Amanda Bowen Kuhn Jan 2008

Fluoride Varnish Use Among Dentists In Virginia, Amanda Bowen Kuhn

Theses and Dissertations

Purpose: The purpose of this study was to asses fluoride varnish use by dental practitioners in Virginia. Methods: Using a cross sectional survey design, all dentists in Virginia who are members of the Virginia Dental Association (VDA) were sent an online survey about usage and knowledge of fluoride varnish. Results: The majority of the respondents were general dentists (79%) followed by pediatric dentists (12%). Fluoride varnish use increased with year of graduation from dental school. Dentists who thought fluoride varnish was more effective and less time consuming use it more than other topical fluorides. Dentists who thought their patients prefer …


Orthodontic Bracket Bond Strength Using Self-Etching Primer With Or Without Pumice Or Acid Etch Pretreatment, Ana Paula Decastro Jan 2008

Orthodontic Bracket Bond Strength Using Self-Etching Primer With Or Without Pumice Or Acid Etch Pretreatment, Ana Paula Decastro

Theses and Dissertations

The purpose of this study was to compare the shear bond strength of orthodontic brackets to enamel in four bonding protocols: SEP without prior pumicing (None), Pre-etch and SEP without prior pumicing (Pre-etch), control: SEP with prior pumicing (Pumice), and Pre-etch and SEP with prior pumicing (Both). 80 extracted bovine incisors were randomly divided into 4 groups of 20, and brackets were bonded under the different experimental conditions. Debonding force was measured with an Instron universal testing machine. A two-way ANOVA comparing the four groups indicated that there was a significant difference in debonding force (P = 0.001). The SEP …


The Possibilities Of Sort Of, Jesse Robinson Jan 2008

The Possibilities Of Sort Of, Jesse Robinson

Theses and Dissertations

Simultaneity and conflict are incessant qualities one is confronted with when looking at things. Shifting from familiar to foreign, from present to implied. There seems to be a tendency, if not necessity to embrace this multiplicity. Using the film theory construct of extra-diegetic and relative qualifier 'sort of' to investigate Pulp Fiction, Bose Wave CD player, Sunset Boulevard, American Apparel, and The Uncanny.


Sli Prevelence [Sic] Among Military Dependent Children, Nicole Reybok Jan 2008

Sli Prevelence [Sic] Among Military Dependent Children, Nicole Reybok

Theses and Dissertations

No abstract provided.


Nasa And The Technology Transfer Process : An In-Depth Appraisal, Susan H. Raizer Jan 2008

Nasa And The Technology Transfer Process : An In-Depth Appraisal, Susan H. Raizer

Theses and Dissertations

No abstract provided.


College Students' Attitudes Toward Singlehood, Lisa Peterson Jan 2008

College Students' Attitudes Toward Singlehood, Lisa Peterson

Theses and Dissertations

No abstract provided.


Design Requirements Of A Sustainable Habitat For Off Grid Operations, Michael Dennis Sisk Jan 2008

Design Requirements Of A Sustainable Habitat For Off Grid Operations, Michael Dennis Sisk

Theses and Dissertations

No abstract provided.


The Relationship Of Outer Ear Characteristics To The Sound Pressure Levels Of Personal Listening Devices, Lisa A. Chandy Jan 2008

The Relationship Of Outer Ear Characteristics To The Sound Pressure Levels Of Personal Listening Devices, Lisa A. Chandy

Theses and Dissertations

No abstract provided.


How Pitchers Getting Ahead In The Count Influences Earned Runs, Joseph E. Carnahan Jan 2008

How Pitchers Getting Ahead In The Count Influences Earned Runs, Joseph E. Carnahan

Theses and Dissertations

No abstract provided.


Quality Of Parent-Child Relationships In Native American Suicidality, Jeri Ann Azure Jan 2008

Quality Of Parent-Child Relationships In Native American Suicidality, Jeri Ann Azure

Theses and Dissertations

No abstract provided.


The Influence Of Exercise Status And Gender On Frequency And Direction Of Exercise-Related Images, Kristen M. Greek Jan 2008

The Influence Of Exercise Status And Gender On Frequency And Direction Of Exercise-Related Images, Kristen M. Greek

Theses and Dissertations

No abstract provided.


Noble Adjustments, Emily Rebecca Elbom Jan 2008

Noble Adjustments, Emily Rebecca Elbom

Theses and Dissertations

No abstract provided.


Experimental Evaluation Of The Effect Of Minimum Quantity Lubrication In Turning Aisi-4140 Steel, Kalyan Reddy Endapally Jan 2008

Experimental Evaluation Of The Effect Of Minimum Quantity Lubrication In Turning Aisi-4140 Steel, Kalyan Reddy Endapally

Theses and Dissertations

No abstract provided.


Evaluations And Outcome Expectancies For Victims Of Child Sexual Abuse, Troy W. Ertelt Jan 2008

Evaluations And Outcome Expectancies For Victims Of Child Sexual Abuse, Troy W. Ertelt

Theses and Dissertations

No abstract provided.


Monitoring Oil-Palm And Other Threats To The Tanjung Puting National Park With Synthetic Aperture Radar, Dave Hartzell Jan 2008

Monitoring Oil-Palm And Other Threats To The Tanjung Puting National Park With Synthetic Aperture Radar, Dave Hartzell

Theses and Dissertations

No abstract provided.