Vessels Of Spirituality: Merging Faith And Form, Maryam Al-Tajer

Theses and Dissertations

According to traditional Islamic teachings, natural materials like frankincense, black sesame seeds, and sidr (jujube) leaves are valuable both physically and spiritually. Historically, they have been used for healing and purification. Nowadays, influenced by contemporary science, people tend to overlook their metaphysical value, focusing on their medicinal uses. Similarly, Muslims assign spiritual qualities to the Muqatta’at, the disconnected letters that preface several surahs of the Holy Quran, believing them to contain sacred power. In both of these cases, the material leads to the spiritual.

Through material experimentation, informed by religious texts, my thesis combines revered materials with sacred letter forms …

Comparative Evaluation Of Three Endodontic Rotary File Systems In S-Shaped Root Canals: An In-Depth Analysis, Mudher Bahar

Theses and Dissertations

Objective: This study compares three endodontic file systems—XP‐3D Shaper⁺, EdgeFile X7 and WaveOne Gold in S‐shaped simulated canals in resin blocks. It aimed to quantify canals volumetric changes post‐instrumentation to guide clinical selection of a system that preserves tooth structure while efficiently shaping root canals.

Methods: Thirty S‐shaped canals in resin blocks were divided into three groups (n=10) for instrumentation with XP‐3D Shaper⁺, EdgeFile X7 or WaveOne Gold using the crown‐down technique and manufacturers recommended settings. A no‐treatment control provided a baseline for volumetric changes measured via CBCT scans analyzed with ITK‐SNAP. Data were analyzed using ANOVA and Tukey’s test …

Between "Hippies In Suits" And "Money Is The Name Of The Game": Farm Animal Advocates' Analyses Of Political Power In The Farm Bill, Jeff Thomas

Theses and Dissertations

The animal agriculture industry annually slaughters roughly ten billion land animals in the United States. What can be done to improve their welfare and lessen their suffering?

Over the past decade, the problem of farm animal welfare and suffering has drawn increasing interest from the effective altruism community, a loose movement of utilitarian advocates seeking technocratic solutions to social problems (Singer, 2015). As effective altruism has become a more potent driver of the animal welfare movement, an increasing number of nonprofits have begun engaging in political advocacy for farm animal welfare. Facebook co-founder Dustin Moskovitz’ Open Philanthropy is the largest …

The Influence Of Gender Identity And Healthcare Delivery Experience On Hiv Screening, Delton Harris

Theses and Dissertations

This dissertation examines the roles of gender identity, healthcare experience, and practitioners' scope of healthcare services in the uptake of annual HIV screening among the understudied population of transgender individuals. Transgender individuals are about half as likely to have an annual HIV screening despite having similar risk profiles to men who have sex with men (MSM). The current HIV guidelines for MSM recommend annual HIV screening because of the risky sexual practice, anal sex with other men. Similar to MSM, transgender individuals who have anal sex with men are at higher risk than the general population for HIV acquisition because …

Assessment Of Drivers Of Light Attenuation In Virginia Reservoirs, Jackson Barnett

Theses and Dissertations

Water clarity in aquatic ecosystems is crucial for submerged vegetation and algal dynamics. We investigated the factors influencing light attenuation (kd) by measuring total suspended solids (TSS), chlorophyll-a (CHLa), and chromophoric dissolved organic matter (CDOM) across thirteen stations located in seven reservoirs. Average kd was 1.69 m^-1 (range: 0.37-3.99 m^-1), with photic depths averaging 3.27 m (range: 1.15-12.43 m). TSS was the primary predictor of light attenuation (R² = 0.57, P = 0.003, SE = 0.053). Average TSS values for each site were multiplied by the slope of the kd-TSS relationship to find the proportion of kd …

Subgingival Microbiomes Of Healthy And Periodontitis Subjects, Tareq Abdulrasoul

Theses and Dissertations

Background: Periodontitis is a common chronic inflammatory disease triggered by the dysbiosis of the subgingival microbiome. 16s rRNA sequencing has been used to profile the subgingival plaque samples in healthy and periodontitis subjects. Here, we have collected subgingival plaque samples from subjects and analyzed the microbiome profile from 16s rRNA sequencing. We hypothesized that periodontitis patients will have a different subgingival microbiome profile than that of healthy subjects.

Methods: Subgingival plaque samples were collected from periodontitis and healthy subjects who were indicated for periodontal surgeries (osseous resective and regenerative surgery for periodontitis patients or crown lengthening for healthy …

Beneath The Roots: Becoming Native Through Mangrove Teachings And Wisdom, Shima Aeinehdar

Theses and Dissertations

Beneath the Roots uses the wisdom of mangroves to investigate the naturalization of humans through science, spirituality, and storytelling. The seeds of Avicennia marina, the gray mangrove, drifted to Qatar at some point in history and took root, like so many other people here. The mangrove survives in a harsh saline environment through a unique salt excretion process. As a Qatar-born expat, I relate to this struggle to survive and nativize in a land that is both my own and foreign to me, in a cyclical conversation. I explore this nativization process through a ritual of salt extraction, creating botanical …

Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …

The Trauma-To-Prison Pipeline: A Multi-Level Theoretical Framework Exploring The Intersection Of Inequality, Trauma, And Exclusionary Discipline, Dana Ainsworth

Theses and Dissertations

The school-to-prison pipeline (STPP) is a widely recognized and extensively studied metaphor used to describe the process by which school discipline policies increase the risk of juvenile justice system involvement, particularly among historically marginalized populations. While it has been instrumental in shaping educational policy, the STPP framework has not evolved to account for the critical impact of trauma on learning and behavioral outcomes. Furthermore, it overlooks the role of systemic inequality that increases trauma exposure and produces concentric patterns of marginalization.

Drawing on research across the fields of education, public health, sociology, and criminal justice, this study proposes a theoretical …

Immersive Medical Practice And Clinical Training: Virtual And Mixed Reality In Pharmacy And Orthopedic Surgery, Silas Semprini De Toledo Contaifer

Theses and Dissertations

Extended‑reality (XR) technologies including virtual reality (VR) and mixed reality (MR) offer new ways to improve training and surgical precision. This thesis evaluates their educational and clinical impact through two complementary studies.

Specific Aim 1 compared an immersive 360° video VR module with conventional training for teaching USP < 797> sterile‑compounding skills to second‑year PharmD students (N = 36). VR trainees raised their knowledge from 6.14 ± 1.55 to 8.69 ± 1.07, yet the overall post‑test advantage versus control was not statistically significant (U = 71.50, p = 0.21). Item‑level McNemar testing showed significant VR‑exclusive gains on three critical questions (K5, K6, …

Guardians Of Their Own: Routine Activities, Risk Perceptions, & Self-Protection Among Police Officers In The Line Of Duty, Amy Clifton-Mills

Theses and Dissertations

This research illuminated how police officers perceive risks in the line of duty and whether police officers implement protective behaviors on duty. This was done by implementing two phases of data collection: focus groups (I) and self-report surveys (II). The focus groups (N = 21) were conducted to inform the self-protective behaviors instrument in the self-report surveys (N =143). Officers self-reported their risk of assault and injury in the line of duty in the next six months to be 33.86% (SD = 27.13) and their risk of felonious death to be 14.4% (SD = 18.1). Results show that …

Investigating The Temperature Effects On Aedes Aegypti And Dengue Virus In Central Argentina: Perspectives From Mathematical Modeling, Morgan H. Jackson

Theses and Dissertations

Dengue virus (DENV) causes over 390 million infections and around 40,000 deaths worldwide each year. DENV is primarily transmitted by the mosquito Aedes aegypti, and both the life cycle of these mosquitoes and DENV transmission are significantly impacted by temperature. In the temperate region of Central Argentina, where dengue outbreaks first began in 2009, outbreaks only occur following new introductions of DENV from other regions. Due to the relationships between temperature and DENV and temperature and Ae. aegypti, the risk of an outbreak changes throughout the year. Here, we develop and analyze mathematical models for both mosquito population dynamics and …

Teaching Under Political Influence: A Multiple Case-Study Examining The Impact Of Curricular Restriction Policy On Community-Connected Instruction (Cci) In Full-Service Community Schools (Fscs), Isaiah Moore

Theses and Dissertations

Scholars describe the political landscape as polarized, where partisanship —loyalty to a particular political party— dictates one’s beliefs. In education, this partisanship is best exhibited through conservative policy restricting curricula regarding race, racism's pervasiveness, gender identity, and how history is taught in public schools. Conversely, Community-Connected Instruction (CCI) affirms students’ culture and builds critical thinking skills in an authentic environment. While studies suggest its benefits to students, the current curricular restriction policy challenges its usage. This form of teaching is closely associated with Full-Service Community Schools (FSCS), which primarily serve underserved student populations. This study examines how FSCS educators in …

Cannabis Use Among Cancer Survivors And The Impact On Cancer-Related Pain, Tiffanie A. Vargas

Theses and Dissertations

With a growing population of older adult cancer survivors—many of whom experience cancer-related pain—interest in medical cannabis as a pain management strategy has increased. This secondary analysis used data from the 2022 U.S. Behavioral Risk Factor Surveillance System (BRFSS) to examine cannabis use behaviors among cancer survivors and assess associations with cancer-related pain. The study had three aims: (1) to describe 30-day cannabis use (prevalence, intensity, and administration routes) by chronic health condition and cancer diagnosis, focusing on non-melanoma skin cancer, melanoma, and other cancers; (2) to compare demographics, health characteristics, and tobacco use by cannabis use status among cancer …

Investigating Mitochondrial Stress Response Mechanisms In Aging, Aileigh E. Daniel

Theses and Dissertations

Mitochondrial dysfunction is widely recognized as a key contributor to aging and age-related diseases. The concept of mitohormesis suggests that low levels of ROS can activate stress-responsive transcription factors, promoting adaptive mechanisms that enhance longevity. We hypothesized that changes in protein abundance under conditions of mild mitochondrial stress reflect an adaptive response, and that commonly altered proteins across diverse genetic backgrounds of mitochondrial stress can help identify key regulators of stress resilience and aging. Our study identified conserved mitochondrial stress response pathways and highlighted candidate regulators for further investigation. These regulators appear to impair mitochondrial energy production by downregulating ATP …

Substrate Preference And Foraging Behavior Of Two Declining Warblers In Appalachian Shrublands, Samantha Fishman

Theses and Dissertations

Abstract Shrubland and early successional habitats (ESH) support a diversity of wildlife, including many declining songbirds. However, nonnative shrubs increasingly dominate these habitats, potentially altering habitat quality by influencing prey availability. Habitat quality can be assessed by observing foraging behaviors of songbirds and identifying preferred and avoided substrates as well as testing the predictions of optimal foraging theory; specifically that birds will maximize their energy gain relative to the costs. We examined foraging behaviors of Golden-winged Warblers (Vermivora chrysoptera; GWWA) and Chestnut-sided Warblers (Setophaga pensylvanica; CSWA) in ESH on private lands in Virginia with varying amounts …

Strength Imbalances And Shoulder Pain In Manual Wheelchair Users Stratified By Age Of Spinal Cord Injury/Disorder (Sci/D) Onset, Ashlyn M. Jones

Theses and Dissertations

Introduction The majority of manual wheelchair users (MWUs) with spinal cord injury or disorder (SCI/D) develop shoulder pain. In adults with SCI/D, there is evidence that upper limb strength imbalances are associated with shoulder pain. However, strength imbalances may indicate protective compensatory strategies, and other factors may be important contributors to pain. Currently, personalized prevention and management of pain is limited, little is known about joint strength imbalances and pain in children who use manual wheelchairs, and the effect of the age of SCI/D onset is poorly understood. The purpose of this study was to assess the effect of age …

Unleashing Serine Palmitoyltransferase In Test Tubes And Mice, Matthew W. Peart

Theses and Dissertations

Canonically known both for structural contributions to lipid bilayers and roles in cell signaling, the sphingolipids comprise a dynamic, multifaceted class of molecules which are studied to understand homeostatic cell biology as well as pathophysiology. Sphingolipids contribute to tissue-specific structures such as myelin, a multilayer membrane that allows for rapid conduction of action potentials along neuronal axons. All sphingolipids are downstream products of the rate-limiting and initiating enzyme in the de novo sphingolipid synthesis pathway, Serine palmitoyltransferase (SPT). Demonstrative of its status as the enzyme that catalyzes a crucial step in a biochemical pathway, SPT activity is strictly regulated. This …

Reply Stop To Stop, Molly A. M. Garrett

Theses and Dissertations

Over the course of 8 years working in progressive political strategy, 2015–2023, I became increasingly critical of the systems, formulas and tools we were using to communicate with voters. Reply STOP to Stop is documentation of my time at graduate school, of wrestling with ideas of political design, language, communication and distribution. I analyzed my past work — all the texts, emails, social media posts, print ads, web banners, videos and other miscellaneous scripted content — and wondered if we would all be better off without it. Would elections be fairer, would there be less fake news, more community building? …

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO₂) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO₂-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO₂ were evaluated, one was synthesized following a specific route and the …

Wander, Wonder: Beyond The Window, Se Young Lee

Theses and Dissertations

This thesis explores how small, site-specific interventions can reframe everyday spaces through acts of observation, walking, and placement. In response to the increasing detachment from physical environments caused by digitized, image-saturated culture, this research asks how gentle gestures might restore presence and embodied perception in overlooked urban sites.

Drawing on the notion of the flâneur and grounded in theories by Peter Zumthor, Rebecca Solnit, and others, walking is employed as a form of spatial inquiry—a way of thinking through movement, of seeing through slowness. Along a recurring route between home and studio, three underappreciated sites were identified and engaged through …

Enhancing Clinical Trial Matching In Molecular Diagnostics: Using Natural Language Processing And Clustering Approaches In Hematological Malignancies, Gillian Fanning

Theses and Dissertations

Clinical trial matching is a critical component of personalized medicine, particularly in the management of hematologic malignancies. At Virginia Commonwealth University (VCU) Health, the Molecular Diagnostics (MDX) Lab produces somatic variant reports and recommends clinical trials based on the presence of clinically significant mutations. However, the current manual trial recommendation process is time-intensive and lacks scalability.

This study introduces a computational framework to streamline and standardize clinical trial matching using natural language processing (NLP) and unsupervised clustering. Trial brief descriptions were analyzed to extract frequent terms, and trials were grouped based on term similarity using joint dimensionality reduction and clustering. …

Developing Bioinformatics Expertise Through The Annotation Of The Gut Microbiome Of Odontotaenius Disjunctus, Keidra E. Carter

Theses and Dissertations

Next-generation sequencing (NGS) technologies have revolutionized biological research by generating unprecedented volumes of genomic data, necessitating advanced bioinformatics tools and specialized expertise to fully interpret complex microbial communities. This study outlines an integrated workflow to characterize the gut microbiome of the wood-feeding beetle Odontotaenius disjunctus. Prokka is employed for functional annotation to identify protein-coding genes and other genomic features, while Kaiju is used for taxonomic classification. DIAMOND is then applied to locate and validate the taxonomic assignments generated by Kaiju by aligning sequences within the contigs to a comprehensive protein database, proGenomes. Functional analysis revealed that the contigs encode proteins …

Understanding The Experiences Of People Of Color Who Engage In Psychedelic Use, Amber B. Livingston

Theses and Dissertations

There is a growing body of research that supports the potential of psychedelic substances being used to support individuals with alleviating mental health symptoms such as depression, anxiety, and existential distress. Though it has been labeled that Western society is within a psychedelic renaissance, it should also be noted that many indigenous cultures have utilized plant-based medicines as a form of healing and connection. Despite the ever increasing amount of studies being conducted, a consistent deficit is the lack of representation of non-White individuals in research samples. Utilizing the theoretical framework of set and setting, the present study aims to …

Radical Hope Amid Generational Oppression And Puerto Rican Well-Being, Natalia Gomez Giuliani

Theses and Dissertations

Oppressive systems (e.g., colonialism, racism, capitalism) create a disparate distribution of power that, through various mechanisms, negatively impacts the health and well-being of members of the oppressed group. Boricuas have experienced over 500 years of oppression, with the island currently maintaining a colonial relationship with the United States. As these adverse effects of oppression are identified, the need for protective factors (e.g., hope) has emerged. This study explored how islander Boricuas practice radical hope, understand their history of oppression and resistance, and how they perceived it to impact their overall well-being. Utilizing a phenomenological qualitative approach, I conducted 15 semi-structured …

Health Equity In Times Of Crisis: The Impact Of Economic And Public Health Shocks On Access To Care Among Women In Zimbabwe And The United States, Vimbainashe Dihwa

Theses and Dissertations

Abstract

This dissertation examines health equity during times of national public health and economic crises by examining access to care among women of reproductive age. Papers 1 and 2 estimate the effects of the 2020 Covid-19 pandemic in the United States (US). Paper 3 examines the potential effects of the 2008 hyperinflation and subsequent economic crisis in Zimbabwe.

Paper 1 assessed the role of health professional shortage areas (HPSAs) in the Covid-19 pandemic-related temporal trends in mental health access among women in the 18 to 44 years age group with self-reported anxiety and/or depression. The findings suggest decreased unmet prescription …

Integration Of Phenotyping Into A Preliminary Investigation Of Stand-Alone Web-Based Cognitive Behavioral Therapy Among A Non-Treatment Seeking Sample, Anna B. Parlier-Ahmad

Theses and Dissertations

Alcohol use disorder (AUD) is the most common substance use disorder. However, most people with AUD do not receive treatment. Among those who do, it is only moderately effective largely due to the heterogeneity of people with AUD. Many of these individuals, particularly those with mild AUD, can reduce or cease alcohol use without specialized treatment. However, efforts to refer those with more severe AUD to community residential or outpatient programs have been largely unsuccessful, especially among women who often face practical barriers like lack of transportation and childcare. Technology offers innovative opportunities to make treatment more readily accessible to …

Narratives Of Illness Identity Development In Adolescents With Cancer, Rachel Holder

Theses and Dissertations

Introduction: Adolescence is a pivotal developmental stage characterized by the development of independence, autonomy, and identity. A diagnosis of cancer can be disruptive to this process (Grinyer, 2009; Hazen et al., 2008; Neylon et al., 2023). How one incorporates cancer into their identity, or illness identity, has been associated with clinical outcomes, including adherence, life satisfaction, psychosocial functioning, and health-related quality of life and could be a target for supportive interventions aimed at adolescents with cancer (Commissariat et al., 2020; Luyckx et al., 2008, 2018; Meyer & Lamash, 2020; Oris et al., 2016; Raymaekers et al., 2020). Prior literature has …

Trauma-Informed Beliefs And Our Child Welfare System, Gabriela Ana Aisenberg

Theses and Dissertations

The integration of trauma-informed care (TIC) into behavioral health and child welfare systems has garnered increasing attention, reflecting a growing acknowledgment of the pervasive and multifaceted impacts of trauma on individuals, families, and service delivery structures (Barnett et al., 2019; Bartlett et al., 2018; Bassuk et al., 2017; Substance Abuse and Mental Health Services Administration [SAMHSA], 2014). Legislation such as the Family First Prevention Services Act (FFPSA) has led to increased adoption of trauma-informed practices through increased funding for training and services (Bowen & Murshid, 2016; Brown et al., 2023). Research shows that providers’ understanding and implementation of TIC is …

Optimal Data Splitting Methods, Sujay Mudalgi

Theses and Dissertations

In predictive modeling, effective data splitting is crucial for creating statistically representative training and validation sets. The state-of-the-art data splitting methods are based on minimizing the energy distance between the split subsets. However, there are a number of limitations in the existing methods, which this dissertation aims to address. First, the existing methods were computationally inefficient. Thus, Chapter 2 proposes a method to scale up these approaches for big data. Here, we introduce scalable Twinning (s-Twinning), which significantly improves the execution speed of data splitting without sacrificing accuracy. Second, the existing methods did not consider the predictive relationship in the …