Digital Commons Network^™

Applying Ceragenins In Translational Medicine: Activating Mesenchymal Stem Cells And Preventing Healthcare-Associated Infections, Aaron L. Zaugg

Theses and Dissertations

Healthcare-associated infections are a major global concern. Increased infections among vulnerable populations lead to millions of deaths, annually, complicated by the emergence of multi-drug resistant pathogens. These infections are often facilitated by medical devices serving as abiotic surfaces that facilitate the formation of biofilms. Notably, colonization of prostheses and other bone-associated medical devices can lead to corrective procedures, revisions and death. To address these issues, inspiration can be drawn from natural sources of bone health and defenses against infection. Cathelicidins are endogenous peptides involved in both bone maintenance and infection control. Ceragenins are small molecule mimics of cathelicidins with broad …

The Joint Effect Of Esg Practices And Financial Development On The Financial Performance Of Asian Companies, Ali Yehia Fouda

Theses and Dissertations

This study examines the relationship between Environmental, Social, and Governance (ESG) practices, financial development, and financial performance in the Asian markets. This research uses econometric models to analyze two key aspects of financial performance: Return on Assets (ROA), and Tobin’s Q. The results show that there is a negative relationship between ESG practices and financial success, highlighting the financial burden imposed by sustainability initiatives. Machine learning model (XGBoost) has been used to check the robustness of the regression model. Some Commonalities and other differences have been recognized. Yet, the regression model results have been relied upon. Financial development serves as …

Predicting Single-Leg Eccentric Hamstrings Strength In Aging Athletes Using Diagnostic Ultrasound- And Survey-Derived Parameters, Lee J. Hinkle

Theses and Dissertations

Introduction: Eccentric hamstring strength declines with age and contributes to mobility limitations. Although Nordbord testing quantifies eccentric strength, few studies have examined it in older adults, and none have predicted strength performance on this test using ultrasound or survey- based measures. Methods: We recruited 122 senior athletes (60 female) at the 2024 Huntsman World Senior Games. Ultrasound-derived cross-sectional area (CSA), echogenicity, and subcutaneous fat thickness, along with demographic and activity data, were used to predict single-leg peak force using Bayesian regression. Models were sex-stratified, and predictors were selected using leave-one-out cross-validation (LOO IC). Results: In males, CSA, age, leg side, …

The Exaggerated Blood Pressure Response To Activities Of Daily Living And Exercise Is Dependent Upon The Fitness Of People With Hypertension, Joseph D. Larsen

Theses and Dissertations

Purpose: Determine if the previously reported exaggerated systolic blood pressure response to daily activity and moderate exercise amongst hypertensive adults could be accounted for by differences in fitness. Methods: 30 normotensives adults (15 low fitness control (LFC) and 15 high fitness control (HFC)) and 15 unmedicated adults with ambulatory hypertension (HTN) participated in this study. Participants completed 24-hour ambulatory blood pressure monitoring (ABPM). Lactate Threshold (LT) and estimated ����̇O2max were determined for each participant. A week later, blood pressure was measured while participants completed 5-minute bouts of treadmill exercise at fixed absolute intensities (2.5 mph 0% and 12% grade) and …

Stuck In The Maze: Syrian Unaccompanied Children Navigating Spheres Of Protection In Egypt, Anouk Pelletier De Chambure

Theses and Dissertations

This research explores the protection of Syrian unaccompanied and separated children (UASC) in Egypt who have fled the Syrian conflict and reflects on the role of formal protection providers and informal networks of solidarity. In hopes of pushing back against the over- essentialization of UASC as vulnerable children, this research unravels the lived experiences of seven aged-out Syrian UASCs who have been living in Egypt for a few years, which reveals their authentic and original crafting of spheres of protection. This thesis aims to contribute to a more extensive and more accurate understanding of the lives and needs of Syrian …

A Tragedy Of Incommensurability: Indigenous Rights And The Limits Of Human Rights Law, Zeina Ali

Theses and Dissertations

This thesis explores the tragedy of incommensurability between indigenous rights and international human rights law. Despite the emergence of frameworks like the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), indigenous calls for sovereignty remain fundamentally unintelligible within a liberal order structured to preserve settler-state legitimacy. Tracing the historical and theoretical evolution of indigenous advocacy, this study critiques the strategic shift from demands for self-determination to claims of cultural rights. It argues that this shift offers no real alternative: self-determination and cultural rights are functionally equivalent, as both are ultimately filtered through legal and political frameworks that cannot …

The Cellular Mechanisms Of Alzheimer's Disease Protection By The Pilra G78r Variant, Wenhan Cheng

Theses and Dissertations

Microglial dysfunction is increasingly linked to Alzheimer’s Disease (AD). Immune receptors like TREM2 and CD33 play opposing roles in microglial activity. TREM2 activation triggers immunoreceptor tyrosine-based activation motif (ITAM) signaling to promote microglial activities, including amyloid-β clearance, but variants in TREM2 such as R47H that impair its function increase AD risk. In contrast, CD33 is an inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) which transmits signals that suppress microglial function. An AD-protective variant in CD33 alters CD33 activity, potentially enhancing TREM2 function. PILRA is another inhibitory immune receptor expressed by microglia that contains an ITIM. A naturally …

Comparative Analysis Of Water Management Practices In Denmark, Egypt And Uganda: Implications For Sustainable Water Management In Uganda, Junior Twehamye Ashaba

Theses and Dissertations

Water scarcity and mismanagement are escalating global challenges, with over two billion people lacking access to safe drinking water and projections indicating that nearly two thirds of the world’s population could face water shortages by 2050 (Jones et al., 2024). This thesis presents an analysis of water governance and management practices in Denmark, Egypt, and Uganda-three countries that exemplify diverse hydro-climatic conditions, socioeconomic realities, and institutional frameworks. The study explains how governance structures, technological innovation, stakeholder participation, and policy design shape water resource outcomes, and how lessons from Denmark and Egypt can inform more resilient and sustainable water management in …

Future Of Work: Implication Of Green Economy On Employment Dynamics In Egypt, Sarah Adel Elgohary

Theses and Dissertations

Is Egypt's green economy a reality or just a policy-level aspiration? This thesis explores the tangible impact of the green economy on Egypt's labor market by examining key sectors—automotive, agriculture, and renewable energy. Through qualitative interviews and focus group discussions with private sector representatives, the study assesses the true implications of the green transition from a business-level perspective, beyond the propaganda and hype surrounding climate policies. What is the current scale of the green economy in Egypt's labor market? What existing policies and regulatory frameworks are in place to support the green economy transition? how urgent is the transition to …

The Social Standing Versus The Mind Standing Of Older Adults In Egypt: Cross-Sectional Analysis Of The Relationship Between Social Capital And Cognitive Functions, Shaza H. Shinaishen Dr

Theses and Dissertations

Introduction: Egypt's population, much like that of other countries, is expected to age considerably over the course of the coming decades. Although biological and socioeconomic predictors of cognitive function have been studied widely, personal level social capital remains unexplored, especially in LMICs.

Purpose: This study primarily investigates the relationship between individual social capital and cognitive functioning among older adults aged 65 years and older in Egypt using the structural and cognitive components of social capital, including group membership, civic engagements, and caregiving roles.

Methods: A cross-sectional survey on 363 older individuals in different geographical and demographic segments of Egypt using …

Ways Of Living And Knowing, Reem El Hassan Mohamed

Theses and Dissertations

After decades of sedentarization, the Muzeina tribe in South Sinai now has new generations born into sedentary lifestyles, never experiencing nomadism like their ancestors once did. This shift has impacted their knowledge system, traditionally shaped by interactions and kinship with nature. Exposure to social media is influencing younger generations' ways of living, raising the older generations’ concerns about their Bedouin identity. Despite being one of the largest tribes in South Sinai, the Muzeina are rarely represented in literature.

This ethnography explores the impact of sedentarization and contextual developments on the Muzeina's knowledge system, inherited from their ancestors. Muzeina’s relationship, and …

Finding Meaning In Loss: The Role Of Attachment Styles, Coping Strategies, And Resilience, Salma Seyam

Theses and Dissertations

Grief is a deeply personal yet universal experience impacted by personal, social, and cultural factors. The present study examines how attachment styles, coping mechanisms, and resilience impact both grief intensity and the ability to find meaning after a loss, within an Egyptian sample. While previous studies have explored the experience of grief, few have looked at these factors within a Middle Eastern cultural context. A total of 140 bereaved Egyptians who experienced the loss of a loved one within the past three years completed standardized measures assessing grief intensity (Prolonged Grief Disorder-Revised; PG-13-R), coping strategies (Brief COPE), meaning-making (Grief and …

Opportunistic Networks On The Move: A Context-Aware Framework For Opportunistic Networking Under Heterogeneous Mobility Settings, Sara Elsingergy

Theses and Dissertations

Most computer networks require continuous end-to-end connectivity between sending and destination nodes for data transfer. However, in certain scenarios—such as disaster zones, geographically remote areas with intermittent or no connectivity, or regions facing peak network loads—such continuous communication paths may be unavailable. A notable example of this challenge occurred during Hurricane Milton in 2024 and the Los Angeles wildfires in 2025, where Starlink provided free satellite internet to support disaster relief efforts and enable communication in affected areas. However, while offering satellite services at no cost can be effective in emergencies, it may not always be feasible on a global …

Exploring The Role Of Religious Media In Shaping Public Perceptions Towards Climate Change In Egypt, Hebatullah Ashour Abdel Fatah Ibrahim Ashour

Theses and Dissertations

Climate change poses significant threats globally, with particular vulnerability noted in developing nations like Egypt. While effective communication is crucial for societal engagement, the role of influential actors like religious media within specific cultural contexts remains under-explored. This thesis investigates the role and communication practices of religious media (Islamic and Coptic Christian) concerning climate change in Egypt, a country where religious institutions command significant public trust and influence. Existing literature highlights gaps in understanding how these specific media outlets navigate and frame climate change discourse.

Employing Framing Theory and Communication for Development (DevCom) Theory as a combined framework, this study …

In-Service Teachers’ Awareness And Professional Development In Egyptian Public Schools, Hanan Mohamed Metawea

Theses and Dissertations

Neuroscience is an emergent field that focuses on studying brain structure and understanding its significance in the learning process. There has been a recent movement in how to bridge the gap between neuroscience concepts and education by incorporating neuroscience principles into the teaching process. However, there have been limited studies in Egypt on how educators understand and utilize neuroscience principles in the classroom. This qualitative exploratory case study examines Egyptian teachers’ understanding of neuroscience concepts and how they apply them in their teaching practices. This case study was carried out in two government schools, including interviews with 11 teachers representing …

Assessing The Impact Of Digital Transformation On Regulatory Processes And Systems Compared To Traditional Paper-Based Processes At The Egyptian Drug Authority, Rania Aa Soliman

Theses and Dissertations

In the past several decades, the rate of scientific and technological advancements in drug development and digital fields have been extraordinary. Internet of Things and block chain technologies are currently viable in the mature cloud computing industry, these transformative examples contrast starkly with the current pharmaceutical regulatory submission, review, and approval process of the EDA. However, with the emergence of initiatives that aim to improve and expedite regulatory decision-making, there is a promising future ahead. These initiatives, if successful, will not only transform the current transactional structure but also leverage scientific and technological advances to deliver patient-centric therapies. This radical …

“Redefining The Fortress” Migrant Experiences, Adaptation And Connection Within Serbian Borderlands, Nicholas J. Leone

Theses and Dissertations

Abstract This thesis seeks to examine migrant experiences due to Serbia's geopolitical significance along the so-called Balkan route, and how this is specifically exemplified in the northern autonomous region of Vojvodina. Serbia’s position outside the external border of the European Union has caused it to be a strategic transit point for migrants en route to desired destinations, typically within Western and Northern Europe. However, the European Union’s externalization policies in partnership with Serbian authorities have played an extensive role in migration mobility patterns and humanitarian conditions for migrants traversing within the Serbian borderlands, specifically along the border with Hungary. The …

Growing Pains: Relations Between Racial Discrimination And Body Esteem With Ethnic-Racial Identity By Pubertal Timing For Female Adolescents Of Color, Emily J. Takamasa

Theses and Dissertations

Puberty is a near-universal experience among adolescents, and yet rarely have researchers considered the racialized contexts and salience it has, for girls of color. Using the phenomenological variant of ecological systems theory (PVEST), this study examines the relation between pubertal timing, body esteem, racial discrimination and ethnic racial identity (ERI) components (affirmation, exploration, resolution) among adolescent girls of color (n = 218, Mage = 15.7, U.S. sample). Results showed that higher body esteem predicted greater ERI exploration and resolution, particularly for girls with average or late pubertal timing. Additionally, racial discrimination was linked to higher ERI exploration and resolution only …

Predicting Secondary Mathematics-For-Teaching Knowledge Using Beliefs, Experience, And School Culture: A Hierarchical Regression Analysis, Adam R. Brulhardt

Theses and Dissertations

Research in recent decades has supported the notion that practice-based mathematical knowledge is crucial for effective teaching, playing an important role in enacting reform-oriented instruction required for improving student achievement. Despite its importance, teachers—especially novices—require more support in acquiring such knowledge, an ongoing challenge exacerbated by teacher shortages. The purpose of this quantitative study was to determine whether collaborative school culture (CSC) explained variance in knowledge of algebra for teaching (KAT) beyond variance explained by mathematics-related beliefs and years of teaching experience for U.S. secondary teachers. Measures within an online Qualtrics survey included the Beliefs About Mathematics and Teaching Scale …

Rapid Beamformer Weight Calibration Update Method For The Advanced L-Band Phased Array Camera For Astronomy (Alpaca), Kayla Lyman Ward

Theses and Dissertations

The Advanced L-Band Phased Array Camera for Astronomy (ALPACA) is a phased array feed instrument designed for the Green Bank Telescope. It is capable of producing 40 real-time beams on the sky, widening the telescope's field of view and significantly increasing survey speed. ALPACA employs an RF-over-fiber (RFoF) signal transport system from the phased array feed front end to the digital backend. This RFoF link is expected to introduce phase delays and changes in gain through out the course of an observation, invalidating the beamformer weights previously calculated. This work presents rapid beamformer weight calibration updates for ALPACA, a method …

Experiences Of Mother-Special Educators With A Disabled Child: A Narrative Inquiry Analysis, Estyr Bomgardner

Theses and Dissertations

Women who are both special educators and mothers of one or more children with disabilities are uniquely positioned in both mothering and disability discourse. In narratives about mothering, having a child with a disability shifts the mothering discourse away from meeting the expectations of good mothering towards deficit-oriented perspectives of both the mother and their child. In narratives about disability, mothers are expected to align with broader societal views that disability is a problem that needs to be fixed. In this study, I used a narrative inquiry approach to ask mothers and special educators to share their stories about mothering, …

First-Year Experience Peer Mentors And Theory Of Generativity; A Generic Qualitative Study, Marie Haughton Flocco

Theses and Dissertations

Student retention is an intricate dilemma for all institutions of higher education. While college enrollment continues to increase, degree completion rates are not keeping pace. Research shows that most students who drop out of college do so during the first year of enrollment. In an effort to address student retention during the first year and ultimately increase completion rates, colleges and universities invest significant resources in what has become known as First-Year Experience (FYE). Peer mentoring programs, in particular, are often an essential aspect of FYE programming because of the successful outcomes reported by mentees. This generic qualitative study diverges …

Wireless Bus Interconnects For Enhanced Small Satellite System Integration And Reliability, Adam Fifth

Theses and Dissertations

In small satellite engineering systems, managing numerous subsystem interconnections presents a significant design challenge directly impacting mission success. Traditional CubeSat subsystems rely on the PC/104 header system for integration, which consumes substantial board area and adds considerable vertical spacing between subsystems. This rigid wired architecture severely restricts subsystem density, complicates assembly and testing procedures, and prevents reconfiguration of interconnections after deployment. This dissertation presents a transformative approach to satellite subsystem integration by developing and validating a Bluetooth Low Energy (BLE) wireless interconnect system replacing traditional wired connections. This research addresses wireless implementation challenges. Through iterative prototype development, I demonstrate a …

Veterans And Higher Education: How Military Service Affects The College Student Experience, Sean M. Berryman

Theses and Dissertations

Higher education has, in the past, paved the road to success for many Americans. Since it currently seems to be the consensus in American society, in general, that a college degree is needed to secure a good job, which leads to a good income in order to provide for oneself and one’s family, college is the road most Americans choose in order to achieve these goals. Since World War II (WWII), veterans have increasingly sought college degrees post-service to bring them in line with their civilian counterparts: they obtained experience in the military, now the degree gives veterans the opportunity …

Development And Miniaturization Of Pad-Printed Carbon Electrodes For Antibody-Type Biosensing, Elizabeth Danielle Clark

Theses and Dissertations

Miniaturized, pad-printed carbon electrodes (PPCEs) offer a promising platform for antibody-type biosensors, enabling rapid and cost-effective point-of-care diagnostics. This study investigates the development, fabrication, and electrochemical performance of large and miniaturized PPCEs functionalized for antibody-type detection, with the eventual goal of detecting pancreatic cancer specific biomarkers. The PPCEs were made of silver- and carbon- based inks that were formulated to be pad printable and conductive and printed on polycarbonate film so they can be easily disposed of after use. Each PPCE was thoroughly cleaned with ethanol several times to ensure a clean base on which to adsorb antibodies and antigens. …

Game, Set, Empower: A Comparative Instagram Analysis Of Branding And Engagement In The Confederation Of African Football (Caf) Women’S And Men’S Champions League, Nour Abdelkader Ms

Theses and Dissertations

The rise of women’s football has placed new emphasis on digital branding, with social media becoming a vital space for visibility, engagement, and representation. This thesis investigates how Instagram content strategies influence fan engagement during the CAF Women’s and Men’s Champions League tournaments. Specifically, it examines the role of content type (match, behind-the-scenes, off-the-pitch, promotional), marketing orientation (organic, sponsored, collaborative), and post format (reel, carousel, photo, graphic) in shaping audience interaction.

Using an explanatory sequential mixed methods approach, the study analyzed 674 Instagram posts (276 CAFWCL, 398 CAFCL) and conducted semi-structured interviews with five digital sports professionals, including CAF digital …

Development Of Preventive Dental Guidelines In The Primary Healthcare Setting In Egypt: A Delphi Method, Basant Mehriz

Theses and Dissertations

This study addresses the critical need for standardized preventive dental care guidelines within Egypt's primary healthcare system amid the rising burden of oral diseases. Through a systematic two-phase methodology combining a comprehensive literature review and a Delphi consensus-building process engaging 35 dental professionals, the research established priorities for contextually appropriate preventive measures. The consensus framework revealed strong support for clinical interventions (mean of 83% agreement), particularly fluoride-based prevention; community initiatives (mean of 83%), especially school-based programs; policy measures (mean of 77%) such as workforce and educational development, though with variable support for taxation and social determinants approaches. Statistical analysis demonstrated …

An Llm Approach For Automating The Analysis Of Bim (Ifc) Data, Miral Selim

Theses and Dissertations

This thesis introduces a novel methodology for automating the analysis of Building Information Modeling (BIM) data using LangGraph, an advanced extension of the LangChain framework, and integrating Google’s Gemini Large Language Model (LLM) with IfcOpenShell. BIM, and specifically Industry Foundation Class (IFC) files, are widely used in the construction industry for representing and managing building data. However, analyzing this data effectively remains a significant challenge due to its volume and complexity. Additionally, analyzing BIM data typically requires knowledge of different BIM software depending on the application. This research addresses this challenge by creating a workflow that utilizes LangGraph’s ability to …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …