Digital Commons Network^™

Relationship Extraction Using Retrieval Augmented Generation For Biomedical Dataset, Jannat Jannat

Theses and Dissertations

With the increasing number of structured and unstructured data, obtaining reliable information effectively has become crucial. In the biomedical domain, extracting information from the scientific papers is crucial in order to stay up-to-date with accurate information, given the increased pace by which new research studies are published. This work focuses on identifying relationships between entities that are extracted from the abstracts and titles of biomedical research papers. In this work, we developed a Retrieval Augmented Generation (RAG) based system to automatically identify relations between biomedical entities. We evaluate multiple open source Large Language Models (LLMs) and the number of examples …

The Proprietor Of Battersea: The Life And Legacy Of American Founder John Banister (1734–1788), Davis C. Simmons

Theses and Dissertations

This research examines the multifaceted life of Colonel John Banister (1734–1788) during the eighteenth century. Using a biographical methodology, the study highlights his significance as an American founder from Virginia. It provides a chronological account of his accomplishments and a detailed analysis of his complex character as a politician, slave owner, and public figure of cultural importance. The research draws on primary sources such as letters and official records, as well as secondary sources including biographies and historiographies that have received limited attention. The thesis argues that Banister’s role as a Revolutionary leader and American founder is underrepresented in current …

Functional Analysis Of Ligand Binding Domain 2 Of Outer Surface Protein C Of Borreliella Burgdorferi, Gavin Z. Chambers

Theses and Dissertations

Lyme disease, caused by the spirochete Borreliella burgdorferi, is the most common vector-borne infection in North America. A critical determinant of early mammalian infection is outer surface protein C (OspC), a highly variable lipoprotein that is indispensable for spirochete survival but whose precise function remains unresolved. OspC has been proposed to mediate diverse roles, including complement evasion, adhesion, tissue dissemination, and antiphagocytic activity, supporting the view that it is a multifunctional virulence factor. Structural studies have identified two putative ligand-binding domains (LBD1 and LBD2), with LBD2 forming a solvent-exposed crown at the membrane-distal end of the OspC dimer.

To …

Implementation Of Quantized Artificial Neural Networks With Spintronic Stochastic Computing, Saadi Sabyasachi Mr.

Theses and Dissertations

Artificial intelligence or machine learning is going through a rapid expansion. It also incurs significant costs for power and device footprints. Various approaches are being explored to design energy and hardware efficient machine learning models. Stochastic computing has been proposed for efficient machine learning implementation. It requires a source of random number generation which poses some practical challenges. So spintronic solutions such as magnetic tunnel junction has been used for random number generation. Again, spintronic random number generation to implement high precision circuit is prone to device-to-device variations. Hence we designed quantized artificial neural network with spintronic stochastic computing which …

Exploring Western Clinicians’ Treatment Of Cultural Concepts Of Distress, Lisa Y. Chung

Theses and Dissertations

As the rates of diverse ethnic populations and therefore cultural concepts of distress continue to grow in the United States, it becomes critical to learn and understand how western-trained mental health professionals are selecting treatments and implementing them. However, there is a paucity of research on cultural concepts of distress as a whole and much less on the psychotherapy of cultural concepts of distress in the United States. This exploratory study aimed to explore the treatment plan of mental health clinicians in the United States when encountering the Korean cultural concept of distress, hwabyung. Ninety-eight clinicians were recruited from Arkansas, …

Facile Synthesis Of Gold, Copper, And Silicon Nanostructures By Laser Ablation In Liquid, Nicholas Simpson

Theses and Dissertations

Metal nanoparticle (NP) synthesis is a continually evolving area of research, owing to the widespread application of NPs in fields such as catalysis, drug delivery, and biosensing. Compared to bulk metal material, NPs contain a larger proportion of surface atoms and exhibit unique optical properties, thus making them ideal for applications where maximizing surface interactions is key. Moreover, their compositions can be altered in several different ways, as evidenced by metal alloy, core/shell, supported, and defective NPs. While conventional synthesis methods are capable of producing NPs in large quantities, they often require conditions of high temperature and pressure, strong reducing …

Theatre As Sanctuary: Queer Identity, Religious Trauma, And The Path To Healing, Casey Worley

Theses and Dissertations

Growing up as a queer individual in a deeply religious Southern Baptist community, I learned early that faith and identity could feel like irreconcilable forces. I sat in the pews, surrounded by voices that preached love but often excluded people like me. For years, I struggled with the question: Can I be both queer and faithful? This tension—between belief and belonging, between the church I was raised in and the identity I could no longer deny—became the foundation of my journey, my artistic practice, and this thesis.

Through this research, I explore the intersections of queer identity, religious trauma, and …

How To Remain A Stranger / Encountering, In A Basement, Hannah Rotwein

Theses and Dissertations

How to Remain a Stranger / Encountering, in a Basement consists of two parallel essays. On the lefthand side of the page, How to Remain a Stranger explores the ways that the legend of the Wandering Jew, the Tradescantia genus of plants, peddlers, and exile relate to my practice of collecting, sorting, and combining found objects. On the righthand side, Encountering, in a Basement describes my thesis exhibition at the Institute for Contemporary Art at Virginia Commonwealth University. Focusing on the idea of the encounter, I detail the materials, considerations, and processes behind four of the ten sculptures in the …

Love Letter, Amy S. Duval Ms

Theses and Dissertations

I applied to graduate school to reconnect with and better understand my studio practice, acquire language, and to disrupt my known ways of making. Generally speaking, I see my practice as being about being seen, and unseen, and the pain and pleasure of being perceived. I’ve learned about my ways of being in the studio. I’ve come closer to speaking honestly about my relationship with my materials, processes, tools, how I value my own labor, and how this informs my work. I am grateful for the cascade of small epiphanies that came and left me while I worked in my …

Dosimetric Validation Of An Electron Monte Carlo (Emc) Algorithm For Small Cutouts And Extended Ssd’S: Assessing Emc In Small Field Dosimetry, Anil Basavaaraju

Theses and Dissertations

This thesis validates the accuracy and limitations of Electron Monte Carlo (eMC) simulations in Eclipse treatment planning systems for small-field electron dosimetry and extended source-to-surface distances (SSDs). Systematic measurements were performed using a microDiamond detector across various electron energies and field sizes. The study examines the discrepancies between measured and calculated (eMC) dose distributions, validating challenges due to lateral scatter disequilibrium and extended air gaps. Our findings provide systematic data for eMC dose calculations and demonstrate that eMC performs within clinical tolerances, with the ultimate goal of enhancing the precision and safety of radiation treatments.

Through The Lens Of Social Media: Examining The Relationship Between Exposure To Social Media Videos Of Police Misconduct And Perceptions Of Legitimacy And Cooperation With Campus Police, Kamal Alhassan

Theses and Dissertations

This dissertation examines how exposure to social media and internet news videos depicting police misconduct influences college students' perceptions of campus police legitimacy, procedural justice, and willingness to cooperate. Although prior research has demonstrated the impact of media portrayals on perceptions of municipal police, limited attention has been given to campus policing contexts. Guided by Tyler’s process-based theory of police legitimacy and Gerbner’s cultivation theory, this quantitative study surveyed 400 students at a large public university in the Southeastern Mid-Atlantic region. Measures included self-reported viewing and engagement with police misconduct content on social media, internet, and traditional media platforms, as …

Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …

Immersive Medical Practice And Clinical Training: Virtual And Mixed Reality In Pharmacy And Orthopedic Surgery, Silas Semprini De Toledo Contaifer

Theses and Dissertations

Extended‑reality (XR) technologies including virtual reality (VR) and mixed reality (MR) offer new ways to improve training and surgical precision. This thesis evaluates their educational and clinical impact through two complementary studies.

Specific Aim 1 compared an immersive 360° video VR module with conventional training for teaching USP < 797> sterile‑compounding skills to second‑year PharmD students (N = 36). VR trainees raised their knowledge from 6.14 ± 1.55 to 8.69 ± 1.07, yet the overall post‑test advantage versus control was not statistically significant (U = 71.50, p = 0.21). Item‑level McNemar testing showed significant VR‑exclusive gains on three critical questions (K5, K6, …

Amplifying Student Voices: A Case Study On The Writing Workshop In A 10th Grade English Classroom, Erin S. Drulis

Theses and Dissertations

This qualitative case study explores how a white, second-year 10th-grade English teacher implemented a culturally affirming version of The Writing Workshop in a private high school serving primarily Black and Latine students from working class families. Through a yearlong collaborative coaching partnership between the researcher and teacher, this study examined how writing instruction might elevate student voice in writing instruction. Grounded in a pragmatic interpretivist epistemology and supported by five intersecting theoretical lenses—democratic education (Dewey), sociocultural constructivism (Vygotsky), culturally affirming pedagogy (Ladson-Billings), critical pedagogy (Freire), and radical love (hooks)—this case study investigated how students used writing as a means of …

Food Waste Renaissance: From The Table, For The Table, Yasamin Shaikhi

Theses and Dissertations

What if waste could be seen as a valuable resource rather than a burden? Food Waste Renaissance (FWR) explores innovative ways to transform excess food and byproducts into sustainable design materials. In Qatar, where food waste constitutes approximately 60% of urban waste, FWR promotes a shift in perception rather than attempting to resolve large-scale waste management issues. By fostering a culture where surplus becomes a resource, it inspires individuals, designers, and communities to embrace and contribute to a circular economy. FWR examines rice and date byproducts as biodegradable raw materials for lamps, bringing material from the table back to the …

Watchpeopledie . Tv, Noah Lebien

Theses and Dissertations

The thesis piece is a performance called watchpeopledie.tv performed four times at the Anderson Gallery in the Hidden Galleries. There are two rooms in the gallery. The first room is where the audience enters. There is a line on the floor marking that the audience is not to move further into the first room or into the second room. The audio consists of verbatim comments sourced from videos of violence against trans people from the website watchpeopledie.tv, a website in which users post real videos of shootings, suicides, car accidents, etc. The main text, which is my thesis writing below, …

Reply Stop To Stop, Molly A. M. Garrett

Theses and Dissertations

Over the course of 8 years working in progressive political strategy, 2015–2023, I became increasingly critical of the systems, formulas and tools we were using to communicate with voters. Reply STOP to Stop is documentation of my time at graduate school, of wrestling with ideas of political design, language, communication and distribution. I analyzed my past work — all the texts, emails, social media posts, print ads, web banners, videos and other miscellaneous scripted content — and wondered if we would all be better off without it. Would elections be fairer, would there be less fake news, more community building? …

Mementos, Zixuan Guo

Theses and Dissertations

Relevance:

Personal Relevance: This project merges my passion for film photography and modern technology, aiming to create a design that bridges traditional and modern practices.

Local Relevance: Richmond’s rich historical context provides an ideal setting to illystrate that traditional arts like analog photography can be preserved while integrating modern digital technology.

Global Relevance: Globally, there is an increasing trend toward combining traditional and modern design approaches, particularly in architecture and interior design. Synthesizing analog and digital means is used to meet the balance between materiality and modern technology (Rose, 2014; Pelizzari & Scrivano, 2011). Designers balance tactile materials like wood …

Enhancing Clinical Trial Matching In Molecular Diagnostics: Using Natural Language Processing And Clustering Approaches In Hematological Malignancies, Gillian Fanning

Theses and Dissertations

Clinical trial matching is a critical component of personalized medicine, particularly in the management of hematologic malignancies. At Virginia Commonwealth University (VCU) Health, the Molecular Diagnostics (MDX) Lab produces somatic variant reports and recommends clinical trials based on the presence of clinically significant mutations. However, the current manual trial recommendation process is time-intensive and lacks scalability.

This study introduces a computational framework to streamline and standardize clinical trial matching using natural language processing (NLP) and unsupervised clustering. Trial brief descriptions were analyzed to extract frequent terms, and trials were grouped based on term similarity using joint dimensionality reduction and clustering. …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

Beliefs Related To Diagnosing Bpd And Complex Ptsd, Bailey Pascuzzi

Theses and Dissertations

There has been speculation that Borderline personality disorder (BPD) and Complex post-traumatic stress disorder (Complex PTSD) are the same disorder or represent separate disorders on a broader trauma spectrum (Frost et al., 2020; Lewis & Grenyer, 2009). BPD and Complex PTSD share several symptoms but differ in their presentation (Ford & Courtis, 2021). Because the two disorders present so similarly, it could be that clinicians have difficulty differentiating them, leading to misdiagnosis (Miller, 2014). This study examined clinicians’ diagnostic decision-making and stigma toward BPD and Complex PTSD. Participants (N = 426) completed an online survey where they diagnosed a written …

“Some Vague Utopia”: Searching For Urania, Moira L. Neve

Theses and Dissertations

Despite the global pendulum swing of gender trouble marked by the United States’ President’s declaration that there are only two sexes, activists have been rejecting assimilation (ie. defining equality as gay marriage or queer people in the military) within queer studies long before 2025. In the first half of the 20th century, a journal by the name of Urania (1916-1940), privately published and circulated to their home base in the United Kingdom and beyond, five editors (Esther Roper, Eva Gore-Booth, Jessey Wade, Dorothy Cornish, and Irene Clyde/Thomas Baty), challenged the gender binary and the resulting assumptions of heterosexual marriage. This …

Social Support, Tobacco Attitudes/Perceptions Of Harm, And Asthma Status As Moderators In The Association Between Tobacco Exposure And Cotinine Levels, Rachel L. Pitts

Theses and Dissertations

Tobacco use and exposure are linked to adverse health outcomes (e.g., respiratory conditions) and increased healthcare utilization (e.g., emergency room visits). This study examined the moderating role of social support, tobacco attitudes/perceptions of harm, and asthma status on associations between tobacco use (e.g., combustible product use) and exposure (e.g., secondhand smoke) and cotinine levels among individuals in Richmond, Virginia. We also explored differences in tobacco-related variables by asthma status and associations among tobacco use, secondhand smoke exposure, cotinine levels, and asthma control. Youth (n = 201) and adults (n = 209) (95.7% Black/African American; 60.6% female; 65.8% non-tobacco users; 21% …

Witnessing Intellectual Humility: How A Peer’S Humble Introduction Affects Feedback Receptivity And Social Perception, Stephanie A. Barrientos

Theses and Dissertations

Might intellectual humility (IH) be contagious? Across two studies, we examined how individuals respond to constructive criticism depending on whether the feedback-giver demonstrated IH—defined as acknowledging one’s limitations and valuing learning. We focused on outcomes related to intellectual (or epistemic) openness in the context of writing, including self-focused state IH (acknowledging one’s own knowledge limitations), other-focused IH (valuing the insights of a peer expert), corrigibility (comfort with being corrected), feedback engagement, and attitudes toward future academic help-seeking in writing (AHS).

In Experiment 1, participants received feedback from a peer who conveyed IH through a brief self-descriptive statement. This subtle manipulation …

Characteristics Of Permanent Teeth Undergoing Surgical Endodontic Evaluation: A Retrospective Study, Yasamin Mojarad

Theses and Dissertations

Objective: This study examines the pre-surgical clinical and radiographic characteristics that may influence the choice of apicoectomy over nonsurgical retreatment in a more detailed approach, focusing on the clinical factors that come into the evaluation phase. We hypothesize that there are certain patterns observed through a pre-operative CBCT that may impact the decision for surgical intervention. The study aims to assess patterns in the decision-making in surgical treatment planning.

Methods: Retrospective review analyzing 142 cases treated or planned for apicoectomy by VCU endodontic residents. Data collected from CBCT and PA radiographs included: restorations, quality of prior root canal treatment, presence …

Isolating Confounding Abiotic And Biotic Effects On The Phenotype On Physa Acuta Snails, Ashley M. Bauer

Theses and Dissertations

Organisms match their phenotypes to prevailing environmental conditions leading to habitat specific polymorphisms. Polymorphisms arise from genetic divergence, phenotypic plasticity, or a combination of both processes. I examined the presence of habitat-specific polymorphism in Physa acuta snails collected from three streams and their corresponding downstream reservoir. In lotic systems shells were rotund with larger apertures, while those from lentic systems were more elongate with smaller apertures. In a reciprocal transplant lab experiment that crossed flow regime and crayfish predator cues, I tested for the underlying mechanisms responsible for the observed phenotypic differences. I found no evidence for plasticity in relation …

From Trans Health To Vaccines: A Theoretically Driven Model Exploring Factors Related To Susceptibility To Medical Misinformation, Catherine Wall

Theses and Dissertations

Medical misinformation represents a significant threat to both individual and public health. While some consequences of this form of misinformation are relatively benign, there can be serious consequences ranging from a decreased trust in healthcare systems to an increased likelihood of epidemic outbreak and death. One such consequence can be seen in the recent legislative actions taken regarding access to transgender healthcare in the United States. Gender affirming care has been shown to benefit the mental well-being of transgender youth and adults; however, the demonstrably false information that underlies these legislative efforts can and has yielded significant harm. But what …

Establishing A Conventional Linac-Based Electron Flash Beam, Justin Defrancisco

Theses and Dissertations

Problems: A rediscovered radiotherapy technique, FLASH, involves increasing the dose rate to >40 Gy/s. For a given dose, FLASH is shown to decrease the normal tissue complication probability without affecting the tumor control probability. More preclinical studies are necessary to confirm and enable these desirable properties on humans. Current preclinical investigations have diverse constraints, requiring FLASH apparatuses with flexible parameters and accurate control. However, there are limited FLASH platforms available, the existing ones are costly. Our institution is not in possession of any such infrastructure. Even if available, dosimetry and beam control in FLASH are extremely lacking. There is …

Psychometric Evaluation: Extending The Reliability And Validity Of The Teacher Attribution Measure For Early Elementary (Tam-Ee), Kerensa R. Nagle

Theses and Dissertations

Teacher attributions of student challenging behavior have the potential to influence teacher-student relationships. However, the literature on teachers’ attributions of challenging behavior is sparse and lacks measurement standardization. This limits the replicability and generalizability of research findings. To determine if teacher attributions of student challenging behaviors influence teacher-student relationships, a measure demonstrating a specific score reliability and validity profile is needed. The present study evaluated the item- and scale-level score reliability and validity of a measure of teacher attribution of student challenging behavior, the Teacher Attribution Measure for Early Elementary (TAM-EE; Nemer, 2019), within a sample of teachers (N …

Sex-Specific Regulation Of Mash And Hepatocellular Carcinoma: A Role Of Sphk2 In Females, Bria Pierre

Theses and Dissertations

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is characterized by excessive fat accumulation in the liver, with metabolic dysfunction-associated steatohepatitis (MASH) representing a more severe form that can progress to cirrhosis or hepatocellular carcinoma (HCC). The sphingosine kinases and the S1P signaling pathway are key regulators of MASH and HCC progression. While much is known about the mechanisms contributing to MASH-HCC in males, less is known for females. Nevertheless, we previously identified sphingosine Kinase 2 (SphK2) to protect females from MASH-driven HCC. This study first performed differential gene expression analysis on human liver cohorts to examine sex-specific differences in gene expression …