Digital Commons Network^™

Propelling Whole-Cell Biosensor Creation By Leveraging Gene Fusion To Assemble Synthetic Functional Transcription Factors For The Detection Of Biomarkers, Samuel J. Verzino

Theses and Dissertations

Biosensors are analytical devices that leverage biological modules for the detection of molecules of interest. As customizable tools designed to aid in a wide array of diagnostics, these instruments are rapidly advancing the field of synthetic biology. While varied in their construction and purpose, biosensors are ultimately concerned with converting a physicochemical stimulus into a detectable signal. Among the many existing variants, whole-cell biosensors (WCBs) stand out due to their versatility and engineering potential. WCBs are a type of biosensor in which a physiologically active cell sustains an array of biomolecular elements - receptors, transporters, regulators, etc. - capable of …

As I Type: An Autoethnography Of Italian (Sicilian) Family Literacies Across Generations In The United States, Kailyn Nicole Giaccone

Theses and Dissertations

This dissertation aims to investigate the racialization of my own family through the examination of migration and citizenship documents, primary sources, and oral histories as told by those who were present for or knew those present for events in question. Participants, including myself, were members of the same family, identified as either male or female, and ranged in age from 30 years to 80 years old. Participants were either monolingual English speakers or multilingual in English, Italian, and/or Sicilian. The methodology used to accomplish this research was autoethnography, which allowed the use of traditional database research, archival examinations of primary …

The Long Shadow Of Pride And Prejudice On Contemporary Fictions Of Arranged Marriage And Marriages Of Alliance, Candice Belluscio

Theses and Dissertations

This dissertation is an examination of the conflicts between arranged marriage and companionate marriage in selected contemporary Anglo-Indian novels and novels about Orthodox Judaism. The project’s guiding focus is how modern ideals of independence and choice in marriage coexist simultaneously with older ideals of marriage as family or personal “alliance.” The dissertation has a historical chapter that shows that although ideals of companionate marriage have become norms of 20th century western society and literature, the term “companionate marriage” is a recent invention and convention, and that various degrees and forms of arranged marriage, or marriages of alliance, continue despite their …

Investigation Of The Binding Mechanisms Between Naphthenic Acids And Humic Acid Using Raman Spectroscopy And Computational Modeling, Jaelyn N. Palmer

Theses and Dissertations

The oil sand regions in Alberta, Canada have proven to be costly to the environment despite its economic benefits. The toxins produced during oil processing are sent to tailing ponds to be recycled, though often leaking into nearby waterways and soil. Naphthenic acids, NAs, are one of the most common toxins produced and have shown to be toxic to aquatic life, animals, and humans. As there is dissolved organic matter in tailing ponds and surrounding environments, tailing ponds often lead to NAs coming in contact with organic material. Humic acid, HA, is a major soil component that has been suspected …

Sonic Futures: Exploring Podcasting, Artificial Intelligence, And The Evolving Landscape Of Composition, Grant David Crawford

Theses and Dissertations

This dissertation investigates podcasting and audio projects as multimodal practices in composition, analyzing how audio-based assignments both challenge and reproduce traditional writing norms. Drawing from personal teaching experience and a dataset of publicly accessible assignment prompts, rubrics, and instructional guides, the study examines how podcast projects are framed, assessed, and implemented in higher education. While often promoted as creative and accessible alternatives to essays, these assignments frequently replicate the same thesis-driven, rubric-centered, and exclusionary structures that define conventional academic writing. Through a cross-textual analysis of fifteen podcast rubrics and fifteen assignment prompts, this project identifies recurring patterns, including paradoxical expectations …

Severity Profiles Of Preschool-Aged Children And Their Associations With Maternal Help-Seeking: A Latent Profile Analysis, Samuel T. Jackson

Theses and Dissertations

Parents of preschoolers are more likely to seek treatment for childhood depression compared to anxiety and behavioral disorders. Atypicality and stability have been implicated in relation to help-seeking, but it is not known how they differ between disorders and whether such differences impact help-seeking. The current study grouped mothers based on their atypicality and stability appraisals across disorders; tested for differences in appraisals between disorders; and then tested for differences in help-seeking based on group membership. Participants were 272 adult mothers of preschool-aged children. Mothers read a series of vignettes describing preschool-aged children with depression, anxiety, and ADHD, and then …

How Therapists’ Perceptions Impact Disseminating And Implementing Trauma-Focused Cognitive-Behavioral Therapy, Maddi R. Gervasio

Theses and Dissertations

In the United States, 60% of youth experience a traumatic event before the age of 18 (Lawrence-Sidebottom et al., 2024) and childhood trauma is associated with a range of psychopathology. Although evidence-based therapies like Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT; Cohen et al., 2017) are available, only 14-22% of traumatized youth receive trauma-specific practices during treatment (Borntrager et al., 2013). Barriers to disseminating and implementing TF-CBT and similar interventions exist at the micro (e.g., therapist and client) and macro (e.g., systemic) levels (e.g., Gervasio & Herren, 2020). Emerging research focused on training in trauma therapists found that therapists’ negative perceptions about the …

Predicting Price Movements Of The S&P 500 Using Conventional And Alternative Market Indicators, Patrick M. Scarborough

Theses and Dissertations

This thesis investigates whether integrating alternative data sources with conventional financial indicators enhances S&P 500 forecasting accuracy in modern financial markets characterized by increased complexity and rapid information flows. The study analyzes daily S&P 500 returns using twelve predictor variables comprising conventional indicators (VIX volatility index, WTI crude oil, gold futures, AAA bond yields, Federal Funds Rate, Treasury yield spreads) and alternative data sources (Bitcoin returns, Daily News Sentiment Index, Indeed job postings, Economic Policy Uncertainty Index) across 1,341 observations from February 2020 to June 2025. The methodology employs ordinary least squares regression and ARIMAX(5,5) modeling with rigorous preprocessing including …

Evaluating Task Demands And Task Characteristics Analysis Among School Psychologists, Alessandra Miceli

Theses and Dissertations

Cognitive ability assessments are central to psychoeducational evaluations, informing decisions regarding interventions and supports for students. While cognitive assessment theories have historically emphasized quantitative data in score interpretation, they have increasingly reflected the need to consider qualitative information, a longstanding tenet of neuropsychological assessment. Frameworks such as the Integrated School Neuropsychology/Cattell-Horn-Carroll (SNP/CHC) Model and the Cognitive Hypothesis Testing (CHT) Model emphasize the importance of analyzing subtest task demands and task characteristics to explain unexpected score discrepancies. Despite these recommendations, little is known about school psychologists’ familiarity with these analyses and their use in the interpretation of test performance. This study …

“Makings Of A Teenage Revolutionary”: An Analysis Of Power Through The Lenses Of Gender And Institution Within The Universes Of Frank Herbert’S Dune And Suzanne Collins’ The Hunger Games, Ayah Cruzado

Theses and Dissertations

It is my objective within this paper to lead us through an in depth analysis of both Katniss Everdeen and Paul Atriedes, investigating every feature of their lives especially in the ways that they compare and differ to one another, after all, it is their written depth and complexity that makes them and their novels so fascinating to the public and earning them fame. Through my exploration, I hope to shed some light on the ways these three elements work and coincide with one another within both narratives. To separate them from one another and simply examine them as independent …

Synthesis And Sar Of Parp Inhibitory Quinoxalin-2(1h)-One Derivatives Carrying Potency- And Selectivity-Driving Adenine-Binding Motifs, Ugochi Ann Adiele

Theses and Dissertations

Poly (ADP-ribose) polymerase (PARP) is a superfamily of proteins comprising 17 members, with PARP1 and PARP2 most notable for their implications in different types of cancer. PARP inhibitors represent an intriguing class of anticancer agents that have garnered increasing interest over the past decade due to their demonstrated clinical efficacy. AZD-9574 is one of these promising PARP1 selective inhibitors with good blood-brain barrier permeability that is currently in clinical trials for the treatment of solid malignancies and previous research attributed its selectivity and efficacy to the presence of a piperazine ring linker in its structure. However, a structure-activity relationship conducted …

Developing Stiripentol Analogs As Potential Ldh Inhibitors For The Treatment Of Glioblastoma, Anshika Y. Jain

Theses and Dissertations

Glioblastoma multiforme (GBM) is a highly proliferative brain tumor that has a 5-year survival rate of ~7 %. Temozolomide (TMZ) is the current standard of care therapeutic for GBM. However, 50% of patients develop resistance to TMZ. Therefore, further investigation for new GBM therapeutics is necessary to overcome this issue of drug resistance. GBM patients are known to overexpress lactate dehydrogenase (LDH), which is inversely correlated with their survival. This key glycolytic enzyme catalyzes the interconversion of pyruvate and lactate and plays an important role in cancer proliferation and invasion. Therefore, we aimed to inhibit LDH for developing therapeutics for …

Enhancing Irs Localization Via Ml-Driven Aoa And Distance Estimation, Nikhila Kotlapara Surendran

Theses and Dissertations

Intelligent Reflecting Surfaces (IRSs) are transforming next-generation wireless networks by enabling dynamic control of the propagation environment for improved localization and security. This thesis advances Angle-of-Arrival (AoA) and distance estimation in IRS-assisted systems using a hybrid architecture with active sensing and passive reflecting elements. A modified MUSIC algorithm, optimized for near-field localization, decouples 2‑D AoA and 1‑D range estimation using a grid-and-peak pseudo-spectrum scan, achieving sub-degree AoA (0.003 rad) and sub-meter range (0.05 m) accuracy with over 100× lower complexity than classical 3D MUSIC.

The study further applies the algorithm to the DeepMIMO dataset (O1_28 scenario, 3.5 GHz) using …

Beyond Homogeneity: Exploring Causal Heterogeneity In Psychopathology, Philip B. Vinh

Theses and Dissertations

Traditional models in psychiatric research often impose assumptions of causal homogeneity, treating population-level associations as reflective of uniform underlying mechanisms. This dissertation challenges that assumption by introducing statistical and machine learning frameworks designed to detect and model causal heterogeneity in the development of psychopathology. Central to this approach is the advancement of finite mixture structural equation modeling (FM-SEM) to identify latent subgroups characterized by distinct, and sometimes opposing, causal pathways.

The dissertation comprises three integrated empirical studies. The first introduces mixDoC, a finite mixture extension of the classical Direction of Causation (DoC) model applied to twin data, enabling the detection …

Blessed Is Anyone Who Will Eat Bread In The Kingdom Of God: Reading The Lukan Meal-Scenes As Proleptic Messianic Banquets Signaling The Dawn Of The End Of Exile, Brian Spencer Kelly

Theses and Dissertations

Scholars frequently claim that there existed an expectation for an eschatological/ messianic banquet in Second Temple Judaism, that the banquet was used as an image for the blessed age to come, and that Jesus’ praxis of banqueting with reputed sinners related to the messianic banquet tradition. These three claims are often assumed, resulting in three problematic trends: evidence for the messianic banquet tradition is often lacking, the tradition is typically treated in isolation from other eschatological expectations, and the tradition’s connection to Jesus’ fellowship is inadequately demonstrated. This thesis begins by surveying the gamut of Second Temple literature for the …

Examining Multiple Stakeholder Perspectives On The Acceptability Of Pain-Mitigation As A Tool To Manage Needle Fear, Sarah C M Morton

Theses and Dissertations

Needle fear affects up to 63% of the global adult population and is associated with significant fear-based medical care avoidance (e.g., blood donation refusal, vaccine hesitancy, insulin injection adherence). Current behavioral treatments have low acceptance in this population, and often fail to address the experience of pain associated with needle procedures. Despite the existence of evidence-based pain-mitigation for needle procedures, these interventions are not commonly used in clinical settings. The current study used qualitative methods to examine patient and provider perceptions of: 1) current methods of needle fear management, and 2) the acceptability of pain-mitigation as an effective tool to …

Glossed Over, Rebecca Oh

Theses and Dissertations

Glossed Over is a collection of interdisciplinary artworks exploring my Korean-American diasporic identity and how gender, queerness, religion, neurodivergence, and internet culture intersect within that experience. Through a blend of painting, woodworking, and sculpture, this installation carries the various elements of undefinable 한 (pronounced: han), a concept I attempt to define and contextualize in the Introduction and throughout this thesis. Each artwork operates through coded language, metaphor, and partial disclosure, offering space for the othered to find recognition through subtle cues and signifiers. Through Glossed Over and this thesis, I scratch the surface of my journey in reconciling generational trauma …

Admissions Advisors' Perceptions Of Adult Learners, Tisha-Stephanie Tovar

Theses and Dissertations

Many assume that college campuses are mostly populated by traditional students fresh out of high school, but this is far from reality. A significant portion of students are non-traditional, or adult learners (ALs), aged 25 to 50. These students typically hold a high school diploma or GED, are financially independent, and have completed little to no previous college coursework (Kenner & Weinerman, 2011). ALs now represent nearly 40% of higher education students (Singh et al., 2021), bringing with them a wealth of life experience as they balance complex careers and personal responsibilities.

This study explored the needs and motivations of …

Mapping Reputational Shifts: Lessons From U.S. Professional Sports Communities During The Black Lives Matter Social Crisis, Dean Austin Hess Iii

Theses and Dissertations

From 2013 through 2024, the Black Lives Matter (BLM) social crisis had profound impacts on major U.S. professional sports communities. Prior crisis research has concentrated on the BLM-related player protests in the National Basketball Association (NBA) and the National Football League (NFL) over momentary periods of upheaval. Based on a review of crisis response and communication literature and its application to sports, this research offers a previously missing longitudinal account of how major professional sports communities (i.e., NBA, NFL, MLB, MLS, NHL, and NASCAR) responded to the BLM social crisis. It aims to offer a better understanding of community group …

Group Flow Perceptions And Dynamics As Compared To Taxonomy And Integrative Group Flow Theory, Karen E. Wirick

Theses and Dissertations

This qualitative study investigated group flow through a team-building exercise with 18 professionals, examining participants’ and an observer’s perceptions of flow in social contexts. Analysis of interviews and observer notes identified eight themes: Sensory Network of Shared Experience, Adaptive Group Identity and Performance, Goal-Skill-Motivation Alignment, Essential Social Dynamics, Calm Intensity, Synchrony and Engagement Patterns, Spontaneous Collective Celebration, and Observer Integration. These themes revealed that flow in groups manifests as dynamic forces in constant motion. When compared to an emergent Taxonomy and the Integrative Group Flow Theory (IGFT), findings aligned more closely with IGFT's conceptualization of flow as a holistic balancing …

Exploring The Perceptions And Experiences Of School Building Leaders At Public Charter Schools And The Impact They Have On The Provision Of Physical Education In Charter School Settings, Nathaniel Bouie Jr.

Theses and Dissertations

This qualitative phenomenology study aimed to explore the perceptions of school principals regarding physical education (PE) and its impact on school programming. Semi-structured interviews were conducted with ten school principals in an urban charter school district in the United States. The interviews were transcribed, and data were analyzed using the phenomenological approach under the lens of teacher socialization.

The findings of the study revealed that physical education was perceived as an inferior subject compared to core subjects such as mathematics, science, and language arts. School leaders viewed PE as less important than other subjects and often reduced its instructional time …

Millennial Leadership Practices: How Are They Choosing To Lead Using The Lens Of Their Managerial Style, Claudia Helen Hesky Archibald

Theses and Dissertations

Despite millennials comprising over one-third of the current workforce, empirical research regarding their leadership practices remains limited. This study aimed to address this gap by investigating: (1) the preferred leadership practices of millennial leaders, and (2) whether millennial characteristics indicate a preference for specific leadership styles. Data were collected from 48 millennial leaders in the United States through online surveys, supplemented by 16 virtual interviews. The analysis revealed that millennial leadership practices, consistent with servant leadership principles, emphasized empowerment and delegation, relationship and community building, and trust cultivation.

'No Girl-On Girl Crime': A Qualitative Interview Study Of How Older Women In The Police Force Experience Competition, Social Support, And Discrimination, Bridget Graham

Theses and Dissertations

Law enforcement remains a male-dominated field in which women continually have to prove they belong. As women achieve recognition and move into high-ranking roles in law enforcement, they encounter unique forms of discrimination and social support opportunities that are shaped by their years of experience. To better understand the unique lived experiences of aging women in the context of the police force, this thesis conducted qualitative interviews with women in their fifties who have achieved success as police officers. Semi-structured interviews with six aging adult women within law enforcement were conducted. The interviews included questions related to the evolution of …

Write What You Know: Serving Others Through Purpose Driven And Honest Storytelling, Breanna Porter

Theses and Dissertations

No abstract provided.

Project Hope: The Impact Of Coaching And Transformation Among Returning Citizens, Mark Keven Cox

Theses and Dissertations

The study of psychological transformation within the prison context appears nascent with few academic articles to be found on the subject. The few that do exist suggest that transformation in the prison context is possible. Drawing from the academic literature regarding psychological transformation, inclusive of Hope Theory and Self-efficacy Theory, this qualitative research sought to understand how cognitive coaching programs within United States prisons may foster psychological transformation and increased likelihood of societal reentry success for returning citizens. The research sits at the intersection of coaching and theories associated with psychological transformation and explores the consequences of a single carceral-based …

Writing Stories That Have An Impact, Andrew Rogers

Theses and Dissertations

No abstract provided.

Exploring Adaptive University President Narratives To Generate Growth And Sustainability, Ryan Charles Weber

Theses and Dissertations

This mixed-methods study explores how university presidents leverage adaptive leadership principles and learning organization frameworks to generate institutional growth and sustainability in higher education. Through analysis of presidential narratives, the research examines the intersection of Heifetz et al.’s (2009) adaptive leadership theory and Senge’s (2006) five disciplines of learning organizations, revealing patterns in leadership communication that drive change. The study analyzed narratives from eight university presidents who demonstrated success through their institutions’ minimum 30% endowment growth over five years. Using thematic analysis and frequency counts, the research identified 198 references to learning organization disciplines, 90 adaptive leadership phases, and 100 …

Black Adolescents' Mental Health And Identity Formation: The Role Of Discrimination And Racial Socialization - A Systematic Review, Tsahai Jenkins

Theses and Dissertations

This systematic review examines the impact of racial discrimination on mental health and racial identity development among Black adolescents, focusing on anxiety, depression, self-esteem, and identity formation, as well as the protective role of racial socialization. Analysis of 19 qualitative and quantitative studies revealed that Black adolescents frequently experience discrimination across various settings, including schools, public spaces, and online platforms, with significant effects on mental health and self-concept. Gendered patterns were evident, with females more likely to internalize stress as anxiety and depression, while males showed externalizing behaviors such as aggression. Racial socialization, especially cultural pride messages, emerged as a …

Culturally Specific Interventions And Indigenous Practices In Correctional And Forensic Settings: A Systematic Review, Jordyne James

Theses and Dissertations

While professional guidelines, legislation and research emphasize the importance of adapting treatment approaches to patient characteristics and culture (American Psychological Association [APA], 2021, 2019; Correctional Service of Canada [CSC], 2013; Canadian Psychological Association [CPA], 2017; Canadian Counseling and Psychotherapy Association [CCPA], 2021), psychological and forensic research and practice related to culturally specific programming lags behind expectations to meet the needs of ethnically diverse clients. Given the continued overrepresentation of minorities within forensic institutions (Aguiar, 2020; Carter & Forsyth, 2007; Hanser & Gomila, 2015; Leguizamo et al., 2018), this systematic review aimed to raise awareness of culturally-specific interventions and Indigenous practices …

Psychopathology, Symptomology, And Treatment In Offspring Of Holocaust Survivors: An Integrative Systematic Review, Lauren Grace Escobar

Theses and Dissertations

This systematic review aimed to evaluate the symptomatology, psychopathology, and treatment of offspring of Holocaust survivors (OHS). A comprehensive search was conducted in PsycINFO, PILOTS/PTSD, and Scopus for studies published between 1990 and 2024. Inclusion criteria required peer-reviewed studies, reports, books, literature reviews, and meta-analyses written or translated into English that reported on symptomatology and treatment for OHS. From an initial yield of 2,532 articles, 119 studies met the inclusion criteria. The findings suggest that OHS demonstrate significantly higher levels of symptomatology and psychopathology reported in nine clinical classifications. Psychodynamic treatment was the most commonly found treatment modality for OHS, …