Digital Commons Network^™

Effects Of Early Alcohol Exposure On Ocular Dominance Plasticity, Crystal Lantz

Theses and Dissertations

Fetal alcohol spectrum disorder is the leading cause of mental retardation in the western world. It is associated with learning and sensory deficits. Some of these deficits are a result of faulty neuronal plasticity. Previously our lab has used ferrets to demonstrate that alcohol exposure during the third trimester of human gestation results in impaired ocular dominance plasticity (ODP). Here we have transferred this model to mice. Mice, treated with 5 mg/kg of ethanol on postnatal days 5, 7 and 9, exhibit a lack of ODP plasticity after 10 days of monocular deprivation (MD) during the critical period of visual …

Identification And Quantification Of Protein Carbonylation By Mass Spectrometry, Qingyuan Liu

Theses and Dissertations

Accumulated evidence indicates oxidative stress plays important roles in disease and aging. Under oxidative stress, lipid peroxidation (LPO) leads to reactive carbonyl species (RCS) that can modify a wide range of biomolecules including protein, DNA and carbohydrate. In this dissertation, we investigate the modification of two model proteins, human serum albumin (HSA) and aconitase (ACO), by the LPO-relevant a, b-unsaturated aldehydes, acrolein (ACR) and 4-hydroxy-2-nonenal (HNE). The investigation is focused on the characterization and quantification ACR and HNE addition to the model proteins. A correlation between HNE modification and ACO activity is also determined. These results provide insights into the …

How Successful Is Homework Success For Children With Adhd?, Alexis Resnick

Theses and Dissertations

ADHD-diagnosed children generally display multiple difficulties with academic functioning (DuPaul, 2007; Loe & Feldman, 2007; Raggi & Chronis, 2006; Rogers, Wiener, Marton, & Tannock, 2009) and tend to show more frequent and intense homework problems than their peers (Power, Karustis, & Habboushe, 2001). Traditionally, treatments for ADHD have included medication and/or behavioral interventions (DuPaul & Weyandt, 2006; Loe & Feldman, 2007); however, interventions targeting the homework problems of children with ADHD have been limited. One such intervention for the treatment of children with ADHD and homework problems, the Homework Success Program (HSP), has yet to be empirically evaluated with individual …

Material Meaning, Anne Jordan

Theses and Dissertations

The synthesis of old and new, analog and digital, and hand- and computer-based methods provides designers with an opportunity to work beyond the constraints of the computer and take advantage of the aesthetic effects that actual materials bring to visual communication. Designers who choose to actively participate in their process – bringing the aesthetic effects of working materially into the realm of the digital – will likely learn to reject an approach that relies too heavily on passive digital tools. Active participation in the design process can extend our creative vocabulary and humanize visual communication.

Opposing Roles Of The Μ-Opioid And Nociceptin/Orphanin Fq Receptors In Oligodendrocyte Development And Myelination, Allison Vestal-Laborde

Theses and Dissertations

While the classical function of myelin is to facilitate saltatory conduction, this membrane and the myelin-making oligodendrocytes (OLGs) are now recognized as regulators of plasticity and remodeling in the central nervous system (CNS). Thus, OLG maturation and myelination are highly vulnerable processes along CNS development. We previously showed that rat brain myelination is altered by perinatal exposure to buprenorphine, an opioid analogue in clinical trials for the treatment of pregnant opioid addicts. We now found that the in vivo effects on myelination could result from direct alteration in the balance between μ-opioid receptor (MOR) and nociceptin/orphanin FQ receptor (NOPR) activities …

Die Zauberflöte: A European Singspiel, Zachary Bryant

Theses and Dissertations

Through modern-day globalization, the cultures of the world are shared on a daily basis and are integrated into the lives of nearly every person. This reality seems to go unnoticed by most, but the fact remains that many individuals and their societies have formed a cultural identity from the combination of many foreign influences. Such a multicultural identity can be seen particularly in music. Composers, artists, and performers alike frequently seek to incorporate separate elements of style in their own identity. One of the earliest examples of this tradition is the German Singspiel. Through the synthesis of foreign and native …

An Investigation Of The Relationships Between Technology Use And Teachers' Self-Efficacy, Knowledge And Experience, Jenith Mishne

Theses and Dissertations

Dramatic changes have occurred in the area of technology development and society's use of technology in daily life and the workplace. Yet in many classrooms, technology integration remains a significant challenge for educators, creating a digital disconnect that threatens to handicap students as they graduate and compete for jobs in the 21st century. The purpose of this study was to examine whether teacher self-efficacy, teacher knowledge, and teaching experience influence levels of technology integration in the classroom. The research question asked was: How well do measures of self-efficacy, teacher knowledge and teaching experience predict teachers' scores on a state measure …

Women In Leadership: Strategies For Work-Life Balance, Kerri Heath

Theses and Dissertations

Although women have been a prominent presence in the workplace for over 5 decades, the struggles surrounding work-life balance still drive some women to opt out of career opportunities. Women now make up more than half of the populations at universities and in the work force, yet they are not advancing into the highest positions at the same rate as their male counterparts. This study seeks to empower women who desire both families and careers by analyzing the work-life balance strategies of women in leadership. Data collected from interviews of 22 women leaders are used to identify strategies that integrate …

Aba In Native American Homes: A Culturally Responsive Training For Paraprofessionals, Belinda Naomi Najera

Theses and Dissertations

This project attempts to create a dialogue about respectful service delivery to Native American families with a child diagnosed with an Autism Spectrum Disorder (ASD). Improving interactions between professionals and Native American families can not only advance the ASD child's cognitive and behavioral gains, but also respectfully honors the beliefs of the caregivers. A systematic search of pertinent peer-reviewed empirical sources in the areas of Autism, paraprofessional training, and multicultural psychology was conducted to develop a training resource for paraprofessionals providing home based ABA tutoring. The completed resource is comprised of three training modules, which are intended to be presented …

The Relationship Of Apathy To Executive Functioning Among Hiv-Positive Adults, Sloane Kimberly Miller

Theses and Dissertations

As the HIV population ages and HAART extends the life span of older HIV+ individuals, it is important to address the neuropsychological, cognitive, and emotional manifestations of HIV in this sub-population. The purpose of the present study was to examine whether apathy and depressive symptoms were associated with executive functioning in older HIV+ individuals. This archival study explored whether four items from the Beck Depression Inventory, Second Edition (BDI-II) could serve as an index of apathy and whether higher scores on these items would be related to greater impairment on measures of executive functioning. The sample consisted of 95 older …

African/Black Psychology: A Qualitative Investigation Of Distinguished Black Psychologists, Nichole J. Mckenzie

Theses and Dissertations

Over the past 40 years, researchers have made numerous attempts to document and expand upon the literature surrounding the development of African/Black psychology. Yet little is known about the contextual factors that might have influenced individual decisions to become involved in the movement. This study examined the early life experience of 13 Black psychologists whose autobiographies were published in Robert Williams (2008) book, History of the Association of Black Psychologists: Profiles of Outstanding Black Psychologists. Data for this study were analyzed utilizing a qualitative research approach. Themes that arose from the analysis included: (a) direct exposure/awareness of oppressive social, political, …

Motivation And Learning Strategies: A Correlational Study Of Employee Training, Cynthia Lee Parmenter

Theses and Dissertations

Increasing the effectiveness of learning within the workplace continues to be a focus for organizations. Given that people will work for many more years than the traditional 30 years of generations past, combined with the ever changing economic environment, individuals and companies must continually improve skills. Previous research has focused on the areas of motivation, self-regulated learning, and instructional design. Within the financial services industry, many analytical skills are required. Because analysis is vital to financial success, organizations spend significant sums of money providing in-depth training. The institution involved with this study uses a vendor that provides online financial analysis …

Initial Construct Validation Of The Color Figure Mazes Test, Kimberly Lee Smith

Theses and Dissertations

Measurement of cognitive abilities across diverse ethnocultural and racial groups has a contentious history, with broad politico-legal, economic, and ethical impact. There is an abundance of literature on attention, concentration, and executive functioning. However, specific literature pertaining to traditionally under-served populations, linguistic minorities and those with low education and literacy levels are limited. This study reports data gathered in an attempt to validate a Spanish language instrument of frontal lobe functioning, called the Color Figure Mazes Test, on monolingual Spanish speaking male day laborers. The instrument was originally developed by the World Health Organization (WHO) and the University of California, …

Feet That Don't Touch The Floor: Perceptions In Marketing Theatre For Young Audiences, Melora Slotnick

Theses and Dissertations

It was once my dream to build the theatre of the future: to develop a new organization in the theatre community that would provide new ideas and imaginative learning. Reality and research, however, have pointed me in a new direction. From my perspective, we do not currently need another organization to add competition within our theatrical community. Though it is often appealing to start from scratch, what we need most now is to enhance our status and quality. Existing theatres must work toward a balance of competition and collaboration. Disparity is not the issue. Countless theatres in our nation and …

Circuit Development In The Dorsal Lateral Geniculate Nucleus (Dlgn) Of The Mouse., Tania Seabrook

Theses and Dissertations

The visual system is one of the most widely used and best understood sensory systems and the dorsal lateral geniculate nucleus (dLGN) of the mouse has emerged as a model for investigating the cellular and molecular mechanisms underlying the development and activity-dependent refinement of sensory connections. Thalamic organization is highly conserved throughout species and the dLGN of the mouse possesses many features common to higher mammals, such as carnivores and primates. Two general classes of neuron are present within the dLGN, thalamocortical relay cells and interneurons, both of which receive direct retinal input. Axons of relay cells exit dLGN and …

Targeting The Endocannabinoid System To Reduce Inflammatory Pain, Sudeshna Ghosh

Theses and Dissertations

The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective inhibition of either enzyme elevates CNS levels of the appropriate endocannabinoid and produces analgesic effects with fewer psychomimetic side effects than Δ9-tetrahydrocannabinol (THC), the primary active constituent of marijuana. While cannabinoid receptor agonists and FAAH inhibitors reliably produce anti-inflammatory and anti-hyperalgesic effects in the carrageenan test and other inflammatory pain models, much less is known about the consequences of inhibiting …

The Role Of Fyn And B-Cell Expressed Adam10 In Early B Cell Development, Germinal Center Formation And Terminal B Cell Differentiation, Natalia Chaimowitz

Theses and Dissertations

In these studies we sought to determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In particular, ADAM10 has been identified as a key regulator of lymphocyte development. Here we report that ADAM10 is dispensable for early B cell development within the bone marrow. However, deletion of ADAM10 from all peripheral B cells or in post-switch cells leads to severe …

Group I Metabotropic Glutamate Receptors On Selective Cellular Subtypes In Epileptogenic Malformed Cortex, William Bruch

Theses and Dissertations

Cortical malformations from altered development are common causes of human epilepsy. The cellular mechanisms responsible for the epileptic state of cortex remain unclear and a significant portion of these cases do not respond to treatment. Previous electrophysiological recordings in the Jacobs lab in a rat polymicrogyria model indicated an increased response to group I metabotropic glutamate receptor agonists in the region adjacent to the malformation (PMZ). In addition there was a novel response in low threshold spiking (LTS) interneurons via mGluR5 activation. To determine whether cell specific expression of these receptors was altered in malformed cortex immunohistochemical stains were performed …

Transformational Leadership Practices Of African-American Pulpit Ministers At Predominantly African American Churches Of Christ In Nashville, Tn, Keith E. Hall

Theses and Dissertations

Historically, African-American ministers in the United States have played a central role in preaching a message of hope and leading African-American parishioners on a journey to discover greater lives of purpose and power. As the needs of members and complexity of ministry increases, African-American ministers are encountering demand that requires a proven style of leadership that produces positive results. Recent literature suggests that transformational leadership has a positive influence on social systems and the overall behavior of followers (Bass, 1998). The purpose of this quantitative study was to evaluate the self-assessed transformational leadership practices of African-American Church of Christ pulpit …

The Picture Memory Interference Test With Iranian Americans: Does First Language Impact Performance?, Shereen Kianmahd

Theses and Dissertations

The purpose of this study was to examine the impact of first language on one's performance on the Picture Memory Interference Test (PMIT). This casual-comparative study examined if Iranian American students whose 1st language is Farsi performed differently from 1st language English-speaking Iranian American and monolingual English-speaking Caucasian students, after controlling for age and gender. To conduct this investigation, 103 Iranian American students who endorsed Farsi as their 1st language and English as their 2nd language were compared to a matched group of 103 monolingual English-speaking Caucasian students. Forty-four Iranian American students who endorsed 1st and 2nd language as English …

U.S. Women Bullying Women In The Pharmaceutical/Biotechnology/Medical Device Industry, Sharon L. Liu

Theses and Dissertations

This empirical study investigated bullying among adult U.S. women in the Pharmaceutical/Biotechnology/Medical Device (PBMD) Industry. A concurrent triangulation mixed method was used. An online survey was sent out consisting of : (a) a modified Einarsen, Hoel, & Notelaers (2009) Negative Acts Questionnaire; (b) open-ended questions about being bullied, witnessing bullying, and how the respondent coped with bullying; (c) demographic questions of the respondent and the bullying perpetrator (if applicable); and (d) questions on whether the respondents had been bullied, witnessed bullying, or perpetrated bullying. Bullying in the PBMD industry is a problem as evidenced by the fact that 61% of …

Telling The Story: Teaching Leaders The Art Of Storytelling And Its Impact On Individuals And The Organization, Julie Jones O’Leary

Theses and Dissertations

There are many different approaches to communicating a story which engages and inspires the audience. The opportunity comes in teaching employees a framework to tell a story that influences outcomes. This study analyzed the effects of a storytelling class delivered to employees of a Fortune 500 organization. Data for the study was sourced from a mixed-method approach: archival interviews, class evaluations, and face-to-face interviews. These methods measured the participants' reaction to the training, evaluated the relevance to the job, and determined the impact of learning the art of telling a story. The findings showed participants reported improved confidence, strengthened relationships, …

Examination Of The Anti-Saccade Task As An Indicator Of Cognitive Functioning In Hiv Infected Individuals, Katherine Clancy Olson

Theses and Dissertations

The advent of highly active antiretroviral therapy (HAART) regimens has resulted in significantly reduced morbidity and mortality due to HIV infection. However, in spite of more effective treatment options, for some individuals, HIV infection continues to be associated with clinically significant cognitive impairment, particularly in the later stages of disease. The purpose of the present study was to examine the usefulness of the anti-saccade task as a measure of cognitive impairment in a community sample of older HIV+ adults. Using an archival data set, this exploratory study examined how performance on the anti-saccade task related to the diagnosis of HIV-associated …

Psychology Internship Training In Evidence-Based Treatments For Youth With Disruptive Behavior Problems, Nathan J. Balfanz

Theses and Dissertations

The implementation of evidence-based treatments (EBTs) has become a topic of significant debate amongst researchers and mental health practitioners alike. While current research has indicated a shift in attitudes amongst treatment providers for what constitutes as "best practices" in treating clients, less is known regarding the dissemination and teaching of EBTs for early career, training clinicians. The focus of this study was to take a closer look at clinical training in EBT strategies, specifically those for children and adolescents with disruptive behavior problems (DBPs). Sixty-four internship training directors and program representatives from American Psychological Association (APA) accredited and Association of …

Biochemical Actions Of A Novel Cis-Terpenone, Lin Zhang

Theses and Dissertations

Abstract BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE By Lin Zhang, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Director: Qibing Zhou, Ph.D Assistant Professor Department of Chemistry

Quinone methides are reactive species due to their electrophilicity, and natural quinone methide analogs have broad biological activities. Based on known actions of cytochrome P450 enzymes, we hypothesized that trans-terpenones can be metabolized in cells to form a cascade of metabolite products, which may be biologically active due to the generation of quinine and quinone methide …

Cns Neural/Glial Progenitors As Targets Of Hiv-1 And Opiates: Effects On Proliferation And Population Dynamics May Alter Behavior Outcomes., Yun Kyung Hahn

Theses and Dissertations

Human immunodeficiency virus (HIV) infected patients with a history of injection opiate abuse have higher incidences of acquired immunodeficiency syndrome (AIDS) and neurological dysfunction. The use of combined anti-retroviral therapy has significantly reduced the prevalence of mortality and progression to AIDS. Due to extended life expectancy, these patients are still at a great risk for HIV-associated neurological disorders and impairment in their later life. Neural progenitor cells (NPCs) play critical roles in brain growth and repair after injury and insult. Pediatric HIV patients whose glial populations are still developing are especially at risk for central nervous system (CNS) damage. Our …

Adam10: A Novel Regulator Of Mast Cell Function And Activation, Travis Faber

Theses and Dissertations

In this study we show, to our knowledge, the first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production following IgE cross-linking and also impaired BMMC stem cell factor (SCF)-induced migration through collagen IV. Mast cells and T helper cells (Th cells) in the peritoneum were reduced in ADAM10 KO mice. In addition, ADAM10 KO BMMC produced significantly less of all cytokines measured following …

Factors Influencing Pharmacists’ Decision To Report Adverse Events Related To Dietary Supplements, Ali M. Alhammad

Theses and Dissertations

Background: The increasing consumption of dietary supplements (DS) has drawn the attention of regulatory agencies, researchers and healthcare professionals. The US Food and Drug Administration (FDA) does not require premarketing assessment of DS considering them safe unless proven otherwise. However, the reporting rate of DS adverse events (DS-AE) is low. Objective: To describe pharmacists’ attitudes and knowledge of DS and DS information resources, and to determine the importance of selected attributes in pharmacists’ decisions to report a DS-AE. Methods: A convenience sample of practicing pharmacists in Virginia was surveyed using a web-based self-administered questionnaire. A conjoint analysis exercise was developed …

The Role Of R7 Regulators Of G Protein Signaling In The Retina, Hoon Shim

Theses and Dissertations

The R7 regulators of G protein signaling (R7 RGS), namely RGS6, RGS7, RGS9 and RGS11, are expressed in the retina along with its binding partner Gβ5. The RGS9-1 isoform is expressed only in retinal photoreceptors and rate-limits the recovery of rod phototransduction by acting as a member of the transducin GAP complex (RGS9-1/Gβ5L/R9AP). The Gβ5L isoform is also only expressed in retinal photoreceptors and acts by stabilizing the GAP complex. The Gβ5S isoform differs from Gβ5L by the absence of exon 1 due to alternative splicing and is expressed in many other retinal cells. Gβ5L is barely detectable in RGS9-/- …

Designing Direct And Indirect Factor Xa Inhibitors, Rami Al-Horani

Theses and Dissertations

Anticoagulants are the basis for treatment and prevention of thrombotic diseases. The currently available medicines are associated with a wide range of adverse reactions that mandates developing new anticoagulants. Several lines of evidence support the superiority of factor Xa (FXa) as a promising target to develop novel anticoagulants. This work focuses on the design of direct and indirect FXa inhibitors using an interdisciplinary approach. As indirect FXa inhibitors, a focused library of tetrasulfated N–arylacyl tetrahydroisoquinoline (THIQ) nonsaccharide allosteric antithrombin activators was designed, synthesized, and biochemically evaluated to establish their structure–activity relationship (SAR). An N–arylacyl THIQ analog having carboxylate at position–3, …