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The Effects Of Aspirin And Cyclosporine On Canine Platelet Function And Cyclooxygenase Expression, John Metcalfe Thomason
The Effects Of Aspirin And Cyclosporine On Canine Platelet Function And Cyclooxygenase Expression, John Metcalfe Thomason
Theses and Dissertations
Immune-mediated hemolytic anemia (IMHA) is one of the most common causes of anemia in dogs. Despite aggressive therapy, there is a 50% mortality rate in IMHA patients, and the most common cause of death is thromboembolic disease, particularly pulmonary thromboembolism. With the high thromboembolism rate in dogs with IMHA, anti-platelet therapy with aspirin can be a life-saving preventative therapy. Along with anti-platelet therapy, immunosuppressive therapy is needed to decrease erythrocyte destruction. Cyclosporine has become a popular medication for immunosuppression in IMHA patients. Unfortunately, recent human reports have suggested that cyclosporine could activate platelets and contribute to a hypercoagulable state. With …
The Impact Of Organochlorine Pesticides And Lipid Biomarkers On Type 2 Diabetes Mellitus, Paul Robert Eden
The Impact Of Organochlorine Pesticides And Lipid Biomarkers On Type 2 Diabetes Mellitus, Paul Robert Eden
Theses and Dissertations
Type 2 diabetes mellitus (T2DM) is classified as a metabolic disorder characterized by hyperglycemia that results from defects in insulin action and/or secretion, and currently affects 8.3% of the US population according to the CDC’s 2011 National Diabetes Fact Sheet. Several contributing factors have been identified to development of this disease. Published evidence indicates type 2 diabetes mellitus (T2DM) patients display lower overall paraoxonase activity and that this may be partially due to genetic variations in the paraoxonase-1 (PON-1) gene. Some bioaccumulative organochlorine (OC) pesticides have been shown to contribute to increased T2DM prevalence. In addition, these OC compound levels …
Salmonella Source And Rate Of Colonization In Two Newly Constructed Commercial Broiler Houses And The Effect Of Used Litter Inoculation In A New House, Lauren Elizabeth Dodds
Salmonella Source And Rate Of Colonization In Two Newly Constructed Commercial Broiler Houses And The Effect Of Used Litter Inoculation In A New House, Lauren Elizabeth Dodds
Theses and Dissertations
The prevalence of Salmonella within poultry environments and on poultry products has been well documented. However, there has not been a study documenting the effect of utilizing used litter in newly constructed commercial broiler houses on Salmonella status or on the rate and source of Salmonella contamination within new houses. Objectives of this study are to 1) determine environmental source and rate of Salmonella spp. colonization in two newly constructed broiler houses 2) to evaluate the effect of mixing used broiler litter with clean litter in a new broiler house. Results of this study suggest that Salmonella contamination of the …
Oil Related Environmental Degradation And Human Displacement: Case Study Of Niger Delta Nigeria, Joshua Onyemachi
Oil Related Environmental Degradation And Human Displacement: Case Study Of Niger Delta Nigeria, Joshua Onyemachi
Theses and Dissertations
Oil wealth enriches Nigeria, but it has not improved the lives of the majority of the masses living in the oil-bearing areas of the Niger Delta. Niger Delta region has been exposed to environmental risks that have caused many to lose their means of livelihood, triggering high level of poverty in the region. This study examines the impact of oil-related environmental problems and how it has induced human displacement in the Niger Delta. Furthermore, it examined the efficacy of the Nigerian environmental policies as it related to the oil-bearing areas. The research found that oil activities have caused more harm …
Optimization Of Seed Propagation Of Seven Native Plant Species, Shane H. Huff
Optimization Of Seed Propagation Of Seven Native Plant Species, Shane H. Huff
Theses and Dissertations
Seven plants native to the moist habitats of the pine savannas, woodlands, and Hillside Bog natural area at the Crosby Arboretum, Picayune, MS, were evaluated under laboratory and nursery conditions to determine seed germination percentage, optimal germination temperature, and the effect of substrates on germination. These native plants include: titi (Cyrilla racemiflora L.), buckwheat tree (Cliftonia monophylla Britt.), flameflower (Macranthera flammea (Bartr.) Pennell), deertongue (Carphephorus odoratissimus (Gmel.) Herb. var. odoratissimus), pink coreopsis (Coreopsis nudata Nutt.), tall ironweed (Vernonia angustifolia Michx.), and swamp bay (Persea palustris (Raf.) Sarg.). Laboratory experimentation concluded with germination and determination of optimal temperature regimes. Tall ironweed …
Why Can't A Woman Fly?: Nasa And The Cult Of Masculinity, 1958-1972, Erinn Catherine Mccomb
Why Can't A Woman Fly?: Nasa And The Cult Of Masculinity, 1958-1972, Erinn Catherine Mccomb
Theses and Dissertations
This is an investigation into the history of masculinity in spaceflight during some of the tensest years of the Cold War era. This dissertation asks why the U.S. did not counter the Soviet launch of the first woman into space. Scholars have pieced together the story of American women’s fight for spaceflight. The dissertation adds another layer to this narrative by analyzing the construction of the astronaut image from 1958 to 1972, a period characterized by a widespread masculinity crisis. Scholars of Cold War America suggest that Americans saw communism, conformity, feminism, homosexuality, bureaucracy, corporations, male consumerism, leisure, automation, and …
Diagnosis And Characterization Of Bovine Viral Diarrhea Virus, Lifang Yan
Diagnosis And Characterization Of Bovine Viral Diarrhea Virus, Lifang Yan
Theses and Dissertations
Bovine viral diarrhea virus (BVDV) is an important viral pathogen affecting all ages of cattle, resulting in significant economic losses worldwide. BVDV infection is associated with a diverse array of symptoms including gastrointestinal disorder, respiratory distress, fetal malformation, stillbirth, abortions, and mucosal disease (MD). Transplacental infections of fetuses between 42 and 125 days of gestation can result in immune-tolerance and the surviving fetuses become persistently infected (PI). PI animals are major reservoir of BVDV and it becomes problematic to control the disease. The objectives of this dissertation were to: 1) develop a cost-effective testing scheme to detect BVDV PI animals …
I'Ve Been Reading About Disaster Lately, Lisa Catherine Mcmurtray
I'Ve Been Reading About Disaster Lately, Lisa Catherine Mcmurtray
Theses and Dissertations
I’ve Been Reading About Disaster Lately is a collection of original poetry which focuses on how identity and agency are shaped through personal and public circumstance, through the intersection of the human and animal, and through the development of language and personal mythology. This collection is preceeded by a critical introduction which analyzes how poets mediate public and private disaster. The introduction specifially focuses on the eight poems written by Bob Hicok in the aftermath of the Virginia Tech Shooting, and examines how language, either in its presence or absence, functions to resolve the disconnect between pre-disaster and post-disaster.
Movement, Space Use, And Cause-Specific Mortality Of Translocated Wild Turkeys In The Mississippi Delta, Kyle Marable
Movement, Space Use, And Cause-Specific Mortality Of Translocated Wild Turkeys In The Mississippi Delta, Kyle Marable
Theses and Dissertations
The eastern wild turkey (Meleagris gallapovo silvestris) was nearly extirpated from the Mississippi Alluvial Valley (MAV) from overharvesting and habitat loss in the early 1900s. Habitat restoration with hardwood regeneration has likely improved habitat suitability for turkeys in the MAV. I studied establishment and movement of translocated turkeys to assess feasibility of turkey restoration in the MAV. Turkeys were translocated to 2 study sites in the MAV during winters of 2009 and 2010. I monitored movement, survival, and resource selection of translocated turkeys using radio telemetry (February 2009–April 2011). Movement increased with increasing resource dispersion. Mortalities did not differ among …
Decellularized Porcine Myocardium As A Scaffold For Cardiac Tissue Engineering, Bo Wang
Decellularized Porcine Myocardium As A Scaffold For Cardiac Tissue Engineering, Bo Wang
Theses and Dissertations
Myocardial infarction (MI) and heart failure are leading causes of mortality globally. Recently, cardiac tissue engineering has become an attractive option for MI treatment due to the following advantages: it might provide optimal tissue performance maintained by viable transplanted cells, and might also stimulate the formation of vasculature supplying oxygen and nutrients in the patched region. However, fabrication of a thick viable cardiac patch with 3D scaffolds that are thoroughly recellularized with desired cells remains a challenge. We hypothesize that the decellularized porcine myocardium scaffold can preserve natural extracellular matrix (ECM) structure, cardiomyocyte lacunae, mechanical properties, and vasculature templates that …
Effects Of Salinity On Growth, Oxygen Consumption Rate And Ion Regulation In Two Ages Of Alligator Gar Atractosteus Spatula, Daniel Edwin Schwarz
Effects Of Salinity On Growth, Oxygen Consumption Rate And Ion Regulation In Two Ages Of Alligator Gar Atractosteus Spatula, Daniel Edwin Schwarz
Theses and Dissertations
The alligator gar Atractosteus spatula is a euryhaline fish found in the Gulf of Mexico and surrounding drainages. However, the extent of its hypo-osmotic abilities are not well understood. To determine effect of salinity on growth, metabolic rate, and osmoregulation abilities the following question was developed: when does the alligator gar have the osmoregulatory capabilities to survive in hyperosmotic environments? To answer this question, two different age groups (60 and 330 days after hatch [DAH]) of juvenile alligator gar were exposed to 4 different salinities (0, 8, 16, and 24 ppt) for a 30-day period. Specific growth rate, oxygen consumption …
Enhancing The Residual Efficacy Of Wood Phytosanitation Using A Silane, Todd Ellis Johnson
Enhancing The Residual Efficacy Of Wood Phytosanitation Using A Silane, Todd Ellis Johnson
Theses and Dissertations
This study investigates use of the organosilane 3-(trimethoxysilyl) propyldimethyl octadecyl ammonium chloride (Si-Quat) as a wood treatment to impart residual moisture and organism control on wood substrates. Study 1, which utilized experimental testing procedures to evaluate mold growth after standardized heat treatment, indicated less surface mold on treated samples. Study 2, which utilized standardized testing procedures to evaluate Si-Quat treated wood’s resistance to subterranean termite attack, indicated greater termite mortality and less feeding on treated wood, as well as increased termite feeding preference for untreated wood. Study 3, which utilized standardized testing procedures to evaluate water repellency, indicated significantly reduced …
Evaluating A Vegetated Filter Strip In An Agricultural Field, Alina Fay Young
Evaluating A Vegetated Filter Strip In An Agricultural Field, Alina Fay Young
Theses and Dissertations
The use of best management practices has become common in recent years, leading to the need for hydrologic models to predict their behavior and effectiveness. A vegetated filter strip at Mississippi State University was used to test two models: the Hydrologic Simulation Program-FORTRAN Best Management Practices Editor (HSPF BMPrac) and the System for Urban Stormwater Treatment and Analysis Integration (SUSTAIN). Water samples were taken during the Spring of 2011 and tested for sediments and nutrients; HSPF was used for computing flows, sediments, and nutrients. The filter strip was not effective at pollutant removal with removal efficiency rates of 68.1, 91.7, …
Evaluation Of A Granulated Paper Waste Product As A Suitable Bedding Material For Horses, Amanda Arrington Youngblood
Evaluation Of A Granulated Paper Waste Product As A Suitable Bedding Material For Horses, Amanda Arrington Youngblood
Theses and Dissertations
Three 14 day trials were used to compare granulated paper(GP) to pine pellets(PP) and wood shavings(WS) as bedding for horses. During days 1 through 5 stalls were cleaned daily of feces only, and stalls were cleaned of both feces and saturated areas from days 6 to 14. For stall cleanliness, PP was cleaner than both GP and WS. Initial pH was greater for both GP and WS compared to PP. The water holding capacity for WS was greater than PP and GP. On day 5 there was ammonia detected for WS during trial 1. GP and WS emitted more ammonia …
Aortic Valve Endothelial Cells And Adhesion Molecules: Implications For A Tissue Engineered Heart Valve, Chelsea Tiller Mcintosh
Aortic Valve Endothelial Cells And Adhesion Molecules: Implications For A Tissue Engineered Heart Valve, Chelsea Tiller Mcintosh
Theses and Dissertations
Children with congenital heart defects and patients with faulty or failing valves have the need for a suitable aortic heart valve replacement. Current treatment options have several downfalls and heavy investigation is being done into the design of an engineered valve to find an alternative that would alleviate many of these issues. Understanding the physiology of how cells interact in vivo is crucial to the construction of such valve. This study investigates the effect of cyclic strain in aortic valve endothelial cells on the adhesion molecules, PECAM-1, ƒÒ1-Integrin, VE-Cadherin and Vinculin. Experiments found that cyclic strain plays a role in …
Validation Of Bioluminescent Escherichia Coli O157:H7 For Use As A Pre-Harvest Food Safety Model, Heather Ann Duoss
Validation Of Bioluminescent Escherichia Coli O157:H7 For Use As A Pre-Harvest Food Safety Model, Heather Ann Duoss
Theses and Dissertations
Cattle are naturally colonized by enterohemorrhagic Escherichia coli within the gastrointestinal tract. The most notorious of the enterohemorrhagic E. coli is E. coli O157:H7, which can cause serious illness to humans if ingested. To ensure that the United States has a safe food supply, research is ongoing in pre-harvest food safety and pathogen intervention strategies. While advances in pre-harvest intervention strategies are encouraging, no method has proven to completely eliminate and/or control O157:H7. A key limitation to successful pathogen intervention strategies is the inability to track and monitor pathogens in a real-time fashion. Through the use of bioluminescent plasmids harboring …
Stress Responses And Attachment Of Listeria Monocytogenes In Food, Dongryeoul Bae
Stress Responses And Attachment Of Listeria Monocytogenes In Food, Dongryeoul Bae
Theses and Dissertations
The rates of the US hospitalization and mortality caused by Listeria monocytogenes was estimated to be the highest of 31 food-borne pathogens including Salmonella, Escherichia coli, Campylobacter, and Clostridium. This pathogen has an ability to survive under extreme conditions widely found in the natural environment and food. Among 13 serovars L. monocytogenes serovar 4b, 1/2a and 1/2b are mainly associated with human listeriosis outbreaks. The deadliest outbreaks of human listeriosis and massive product recalls in multi-states were associated with ready-to-eat (RTE) food products such as mexican-style cheese, turkey deli meat, cabbage, and cantaloupes contaminated with the bacterium. Thus, contamination of …
Tennessee Williams And The Reinvention Of The Southern Plantation, Elizabeth Faye Coggins
Tennessee Williams And The Reinvention Of The Southern Plantation, Elizabeth Faye Coggins
Theses and Dissertations
The first chapter consists of an overview of the southern plantation as it survives in cultural imagination, especially in William Faulkner’s Absalom, Absalom! and Margaret Mitchell’s Gone With the Wind. The second chapter discusses A Streetcar Named Desire and how Williams reimagines the plantation in an urban setting through the New Orleans Marigny neighborhood. The third chapter examinesWilliams’s reinvention of the rural plantation in Cat on a Hot Tin Roof. The conclusion explores how Williams’s work is used as a blueprint in representing the plantation in postsouthern literature and culture.
The Biology And Management Of Phytophagous Stink Bugs (Pentatomidae) In Mississippi Soybean Production Systems, James Wesley Mcpherson
The Biology And Management Of Phytophagous Stink Bugs (Pentatomidae) In Mississippi Soybean Production Systems, James Wesley Mcpherson
Theses and Dissertations
Stink bugs are the most economically important insect pest of soybeans in Mississippi. This study focused on several aspects of stink bug biology and management. One study examined the residual activity of certain insecticides. Rain was shown to reduce residual activity and after three days most insecticides provided very little control of stink bugs. Stink bugs complete at least one generation a year on early season hosts before moving into soybeans. A study of these early season hosts found that rice stink bug was more prevalent on grasses than the other hosts sampled. Brown stink bug was found on all …
The Comparative Effects Of Arginine Vasotocin On Reproduction In The Boreal (Bufo Boreas Boreas) And Fowler's (Bufo Fowleri) Toad, Tricia Marie Rowlison
The Comparative Effects Of Arginine Vasotocin On Reproduction In The Boreal (Bufo Boreas Boreas) And Fowler's (Bufo Fowleri) Toad, Tricia Marie Rowlison
Theses and Dissertations
The aim of this study was to compare the effects of arginine vasotocin (AVT) administration in the endangered boreal toad (Bufo boreas boreas) and common Fowler’s toad (Bufo fowleri). The objectives of this study were to determine if AVT could elicit: 1) calling, and 2) amplexus behaviors. Toads were paired into single male:female groups and administered AVT at varying concentrations: 0.1, 1.0, 5.0, 10.0 and 25.0 μg/g and in different combinations: 1) only male was treated; 2) only female was treated, and 3) both male and female treated. AVT failed to stimulate any breeding behavior in the boreal toad, but …
Investigation Of A Possible Association Between Pon1 Polymorphisms L55m And Q192r With Coronary Artery Disease And Type 2 Diabetes Patients Within A Southern Population, Chiquita Yvette Mcdaniel
Investigation Of A Possible Association Between Pon1 Polymorphisms L55m And Q192r With Coronary Artery Disease And Type 2 Diabetes Patients Within A Southern Population, Chiquita Yvette Mcdaniel
Theses and Dissertations
Mississippi has a very high prevalence of coronary artery disease (CAD) and type 2 diabetes (T2D), especially among African Americans compared to Caucasians. This project determined the L55M genotypes of paraoxonase 1 (PON1) in 187 people and evaluated associations of PON1 single nucleotide polymorphisms (SNPs), Q192R and L55M, with CAD and T2D in a Mississippian (southern) population. Significant associations were found with PON1 SNPs and race: genotypes LL, LM, QR, and RR showed significant associations with race (p values 0.0000955, 0.0024, 0.00001244, and 0.00001676, respectively), and combined genotypes LMQQ and LMRR were significantly associated with race (p values = 0.0001013 …
Lipid Accumulation In Synthetic Wastewater-Grown Oleaginous Microorganisms, Andrew Thompson Ford
Lipid Accumulation In Synthetic Wastewater-Grown Oleaginous Microorganisms, Andrew Thompson Ford
Theses and Dissertations
Wastewater has been shown to contain the necessary nutritive requirements for the growth of microorganisms. The term, oleaginous, has been given to a classification of microorganisms know to produce up to twenty percent of the weight as oil. This study is designed to examine the potential accumulation of lipids within an oleaginous consortium grown on synthetic wastewater. Potential of the fluorescent stain, Nile red, as a lipid detector is also emphasized. Percentages of extractables greater than thirtyive percent were achieved within the oleaginous consortium using a nitrogen-limited medium. Low pH was found to increase the percentages of extractables. Xylose was …
Modeling Effects Of Climatological Variability And Management Practices On Conservation Of Groundwater From The Mississippi River Valley Shallow Alluvial Aquifer In The Mississippi Delta Region, Robert Frank Thornton
Modeling Effects Of Climatological Variability And Management Practices On Conservation Of Groundwater From The Mississippi River Valley Shallow Alluvial Aquifer In The Mississippi Delta Region, Robert Frank Thornton
Theses and Dissertations
Ninety-eight percent of water taken from the Mississippi River Shallow Alluvial Aquifer, hereafter referred to as “the aquifer” or “MRVA,” is used by the agricultural industry for irrigation. Mississippi Delta agriculture is increasingly using more water from the MRVA and the aquifer has been losing about 300,000 acreeet per year. This research expands on previous work in which a model was developed that simulates the effects of climatic variability, crop acreage changes, and specific irrigation methods on consequent variations in the water volume of the MRVA. This study corrects an identified problem by replacing total growing season precipitation with an …
Growth And Swimming Endurance Of Juvenile Channel Catfish In High Temperature Environments, Michael B. Arnold
Growth And Swimming Endurance Of Juvenile Channel Catfish In High Temperature Environments, Michael B. Arnold
Theses and Dissertations
Channel catfish (Ictalurus punctatus) are important to aquaculture and natural ecosystems, however little is known regarding effects of high summer temperatures, which are predicted to increase with climate change. Therefore, two studies were conducted to examine physiological effects of high temperatures on juvenile channel catfish. The first examined effects of three cycling thermal regimes (23-27°C, 27-31°C, and 31-35°C) characteristic of culture environments in Mississippi on growth, food consumption, feed conversion ratio, specific growth rate, and activity. The second study measured active and resting metabolic rates and swimming endurance at constant temperatures (27, 31, and 35°C). The best growth and feed …
Identification And Characterization Of C-Type Lectin Genes In Reniform Nematode, Satish Ganji
Identification And Characterization Of C-Type Lectin Genes In Reniform Nematode, Satish Ganji
Theses and Dissertations
Reniform nematode, Rotylenchulus reniformis is a semi-endoparasitic nematode infecting over 300 plant species including important fiber crops like cotton. Introgression of reniform nematode resistance from a distantly-related resistant species Gossypium longicalyx into cultivated upland species Gossypium hirsutum has been a challenge. An approach towards achieving nematode resistance in crop plants has been to identify candidate parasitism genes expressed in the nematode facilitating infection of host plant species, and silencing the same through reverse genetic approaches like RNAi. A cDNA library constructed from the sedentary female stage of reniform nematode revealed an EST coding for C-type lectins and occurring in high …
Evaluation Of Varying Digestible Lysine Levels On The Reproductive Parameters Of Cobb 500 Broiler Breeders And The Performance Of Their Progeny, Leonel Mejia
Theses and Dissertations
The effect of decreasing digestible lysine (dLys) intake by broiler breeder (BB) hens from 35 to 45 wk of age on their reproductive performance and performance of their progeny was evaluated. Two types of diets were fed: a diet from commercially available ingredients consisting of dLys intakes of 1,200 (IDL) and 1,010 mg/hen/day (ID) and a semi-purified diet with dLys intakes of 1,010 (SPL) and 600 mg/hen/day (SP). Hens fed the SPL and SP diets had lower hen-day egg production compared to BB hens fed the IDL and ID diets. Fertility and hatchability of eggs set were lowest (P <0.05) for hens fed the SPL diets. Chick weight at hatch was lower (P<0.05) for those that came from the SP and SPLed hens, but 42 and 56 day body weights (BW) were similar for all treatments. Marginal improvements (P<0.10) in FCR were seen at 42 and 56 days for chicks from IDed hens compared to IDL hens. A decrease in daily intake of dLys appeared to improve BB reproductive performance when hens were fed a semi-purified diet and the same response was not observed in hens fed a diet from commercially available ingredients. Furthermore, the progeny study revealed marginal improvements in some live performance parameters. In a second study, a diet based from corn-soybean meal and formulated to a dLys intake of 1,000 mg/hen/day (CS) and three diets composed primarily of corn, soybean meal, and DDGS with 1,000 (DDGS-1,000), 800 (DDGS-800), and 600 (DDGS-600) mg of dLys/hen/day were fed to evaluate the reproductive performance of BB hens from 24 to 42 wk of age. Feeding diets composed of commercially available ingredients with dLys intake levels below 1,000 mg/hen/day did not impact BB reproductive performance. Reduced BW, carcass and breast weight, and higher (P<0.05) back half weight at 42 days of age was observed from broilers that came from 26 wk old BB hens fed the DDGS-600 diet. Reducing dLys intake in later BB hen ages did not impact progeny performance or carcass characteristics. This suggests that Lys may be in dietary surplus concentrations for commercial breeders under current practical conditions.
Effects Of Specific Instructional Practices On Independent Writing Of Learning-Disabled Students, Astrid Monforte
Effects Of Specific Instructional Practices On Independent Writing Of Learning-Disabled Students, Astrid Monforte
Theses and Dissertations
This mixed methods case study explored the effects of conferring, mentor text, and guided practice on independence in writing, increased time on task, and improved written output for fifth grade learning-disabled students serviced in a replacement language arts special education setting. Qualitative data was collected through pre and post interviews with teacher and student participants. Student writing samples were also assessed for sentence structure and support using the Educational Records Bureau (ERB) scoring rubric. Student avoidance behaviors were recorded during independent writing while each instructional practice was presented. This quantitative data was analyzed along with the ERB scores through cross-case …
Display, Baldwin Amanda
Display, Baldwin Amanda
Theses and Dissertations
I will discuss six art works that have a range of characteristics, but can all be unified through the notion of surface, both physically and conceptually. I will investigate how ideas of taste, assumption, collage, façade, figure/ground, display and value can all be seen through this lens. Much significance and symbolism is imbued in such a thin layer and I am actively aware of this as I work. The way I construct and render my subjects and the space in which they reside determines how they are viewed, perceived, considered, and judged by others.
Synthesis And Biological Evaluation Of Second Generation Anibamine Analogues As Novel Anti-Prostate Cancer Agents, Shilpa Singh
Synthesis And Biological Evaluation Of Second Generation Anibamine Analogues As Novel Anti-Prostate Cancer Agents, Shilpa Singh
Theses and Dissertations
Prostate cancer is the most prevalent non-cutaneous cancer among men. Since the 19th century when Virchow first introduced the concept of inflammation in cancer, chemokines and their receptors have garnered a lot of interest. Chemokine receptor CCR5 has been especially implicated in many disease states and recently found to be over expressed in prostate cancer cell lines. Anibamine, a natural CCR5 antagonist discovered in 2004, has been found to have significant anti-prostate cancer activity at micromolar level. To optimize this compound and also discover a novel pharmacophore, exploration of the original structure was carried out. Significant modifications were made to …
Reflections On Sexuality, Sensuality, And Painting, Loie Hollowell
Reflections On Sexuality, Sensuality, And Painting, Loie Hollowell
Theses and Dissertations
The written component of my thesis will take the form of an extended artist statement in which I discuss all six paintings included in my thesis exhibition. A major theme of my work is sexuality, specifically female sexuality. This thesis will begin by looking at the three miniature paintings that spearheaded the investigation of this theme. I will examine the generalized and personal feminist symbolism that these paintings contain. The two works that followed the miniatures are depictions of sexual interactions between my husband and myself. I will explain the significance of my depictions and relate them to the work …