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Naqbu: Cosmological Undercurrents In Sumer And Akkad, Fiona Eirene Andrews

Theses and Dissertations

The concepts of primordial incomprehensibility, ordered creation, and the liminal chaos between them, form a foundational framework in Mesopotamian intellectual culture. The distinctive ways in which these concepts manifest in Sumero-Akkadian cultures suggest a systematic cosmological substructure — characterized by the paradoxical, cyclical, and co-creative relationships between forces such as Infinity and measure, generation and destruction, and definition and obscurity — that remains insufficiently examined in current scholarship. Drawing from diverse corpus of Mesopotamian creative works, Kabbalistic exegesis, and post-modern scholarship, this thesis seeks to elucidate the essential dynamics within that substructure. By proposing a semiotic hermeneutical strategy attuned to …

Exploring The Ancestry And Mutational Signatures Of Free-Breeding Dogs From Chernobyl And The Galápagos Islands, Gabriella Jean Spatola

Theses and Dissertations

Two free-breeding dog populations, one in Chernobyl, Ukraine, and the other on the Galápagos Islands, Ecuador, exist on opposite sides of the globe, yet both hold unique scientific potential to further our understanding of free-breeding dog population dynamics and evolutionary processes related to their environments. In the following studies, blood samples from more than 400 individual Chernobyl dogs were collected and their genomes were analyzed alongside over 1500 purebred and 200 global free-breeding dogs, describing genetic relationships and the extent of admixture with purebred migrants. Importantly, the sampled Chernobyl dogs had long-term exposures to ionizing radiation because of the 1986 …

The Return Journey: Migration, Reintegration, And Postcolonial Identity In Contemporary African Literature, Babila Bengala Samuel

Theses and Dissertations

Migration is a human practice as old as human society. It is primarily triggered by a human urge for self-preservation or the quest for better standards of living. Various periods of human history have known great flows of voluntary, semi-voluntary, and forced migrations. In contemporary days, people move more than ever before, mostly from countries of the Global South to countries of the Global North, mainly from African countries. These migrants flee from poverty, armed conflicts, unemployment, and repression from despotic leaders. While the question of migration has consistently and extensively been addressed, the focus in the mainstream migration studies …

Inorganic Nanoparticle And Nanoplastic Transformations And The Impact On Biouptake By Freshwater Algal Cells Using Single Cell And Single Particle Inductively Coupled Plasma Mass Spectrometry, Elizabeth Carey Bair

Theses and Dissertations

The ubiquitous presence of nanoparticles (NPs) and nanoplastics (NPPs) and their effects on environmental and human health is a significant concern. They are used in every aspect of our lives, and while they offer many benefits, there are concerns about their impacts on ecosystems and human health. The primary aim of this dissertation is to quantify NP and NPP transformations in the presence of algae and determine how those transformations influence bioavailability. The methodology involves two complementary analytical techniques: single particle (SP) and single cell (SC) inductively coupled plasma mass spectrometry (ICP-MS). These techniques are tested and applied to two …

Reluctant Transitions: Place And Post-Extraction Politics In Southeastern Ohio, Jenna Lynn Haver

Theses and Dissertations

Based on a summer of ethnographic research in a subsection of Appalachian Ohio colloquially referred to as “The Valley,” this research challenges three narratives of this place that formulate a harmful Appalachian imaginary. The first narrative of industrycontrolled coal heritage is complicated by the way local people negotiate control over their own stories of coal and its existence outside of industry domain. The second narrative characterizes this as a space of extraction which is in tension with different social relations to varying types of energy – especially the discontinuity of the coal to fracking shift. The third narrative centers of …

“Cruelty, Bloodshed, And Degradation From The Inauspicious Conjunction Of Stars”: “Magic” In The 1857-58 Rebellion In India, Summer Bordon

Theses and Dissertations

During the 1857-58 rebellion in India, British soldiers and civilians saw ample evidence of Indian belief in “magic”. Prophecies about the end of British rule were implicated in inciting rebellion. When a solar eclipse occurred during the British army’s campaign to regain control of Delhi, victory was attributed partially to Indian superstition. Much of the historiography of the 1857-58 rebellion has uncritically accepted British sources’ conceptions of Indian “magic”, dismissing it as superstitious, politically hindering, and divorced from material reality. Yet, British understandings of magic cannot be taken at face value. Instead, they must be located within broader colonial narratives …

Characterizing The Relationships Between Cranial Geometry, Brain Morphometry, And Brain Mechanical Properties Using Mr Imaging And Elastography, Jessica Restivo

Theses and Dissertations

Traumatic brain injury (TBI) is a global health concern, with over 69 million cases annually. TBI risk depends on subject-specific neuroanatomical variation, yet research often only considers generic finite element (FE) models, based on the geometry and material composition of a 50th percentile male head. Although highly accurate, subject-specific models require expensive magnetic resonance (MR) imaging, elastography, and time-consuming computational resources. There is a need to create subject-specific TBI models that account for subject-specific variations, without neuroimaging. This study aims to create mathematical models to predict brain morphometry (dimensions, volume) [Objective 1] and mechanical properties (shear stiffness, damping ratio, octahedral …

Transitioning From Microfluidic-Based To Bioprinted Decellularized Extracellular Matrix In Vitro Blood–Brain Barrier Models, Connor O. Mowen

Theses and Dissertations

The blood–brain barrier (BBB) regulates transport between the vasculature and central nervous system but limits therapeutic delivery. In vitro BBB models are essential for studying barrier function, disease mechanisms, and drug transport, yet traditional systems often lack biological relevance. This thesis aimed to improve model fidelity and scalability by refining a PDMS-based microfluidic fabrication protocol and developing a spinal cord-derived decellularized extracellular matrix (dECM) bioink for bioprinting applications. A multi-step protocol was optimized to decellularize bovine spinal cord tissue, followed by enzymatic digestion to generate a printable dECM solution. UV–Vis spectroscopy confirmed protein retention, and DNA quantification revealed residual nucleic …

The Future Is Inclusive, Victoria Mcclendon

Theses and Dissertations

Victoria McClendon THE FUTURE IS INCLUSIVE 2024-2025 Stephanie Lezotte, Ph.D. Master of Arts in Higher Education This research explores the role of Diversity, Equity, and Inclusion (DEI) programs in higher education, specifically focusing on the impact of inclusion through Rowan University’s Unified Sports program. DEI programs are designed to support historically underrepresented groups, including students of color, LGBTQ+ students, students with disabilities, and other marginalized communities. This study examines the importance of DEI in fostering inclusive educational environments and investigates the consequences of removing such programs. A qualitative case study approach is employed, involving group interviews with students and faculty …

Effects Of Stressor Exposure And Locus Coeruleus Opioid Signaling On Coping And Anxiety-Like Behavior In Rats, John Arthur Tkaczynski

Theses and Dissertations

Stress is a physiological state of altered neuroendocrine signaling and heightened indices of behavioral vigilance and arousal in response to threatening stimuli. This project aimed to investigate the adaptations to stress that occur in the noradrenergic locus coeruleus (LC) and how these changes affect stress coping behavior. We began by investigating how adolescent restraint and predator odor stress affects coping when presented with a secondary noxious stimulus in the defensive shock probe burying task one week following stressor exposure, finding that stressed male rats demonstrate a more active coping response and stressed female rats demonstrate a more passive coping response, …

Integration Of Mechanism-Driven Computational Modeling And Public Data Resources For Chemical Toxicity Assessment, Elena Chung

Theses and Dissertations

Regulatory toxicology depends primarily on animal testing, which limits throughput, mechanistic interpretability, and applicability to human-relevant endpoints. This dissertation presents computational approaches that integrate publicly available bioactivity data with machine learning to support chemical safety evaluation. Oral carcinogenicity was modeled using curated chemicals from the US Environmental Protection Agency’s Integrated Risk Information System (IRIS) and activity data from over 1,900 PubChem assays. Quantitative structure-activity relationship (QSAR) models trained on statistically prioritized assays demonstrated strong predictive performance and were applied to rank the carcinogenic potential of more than 16,000 compounds. Hepatotoxicity was evaluated using a hybrid modeling approach that combined structural …

Development Of Biodegradable Mg-1zn-0.5sc Alloy & Surface Treatment Through Laser Shock Peening And Evaluation Of Microstructure & Property Correlation For Orthopedic Implants, Parameshwari R

Theses and Dissertations

Magnesium (Mg) and its alloys are of much interest as promising third-generation bio-materials for bone implant applications; however, challenges remain for the alloy's mechanical integrity and bio-corrosion behaviour. Therefore, appropriate alloying elements and surface-modification techniques are required to overcome these limitations. Zinc (Zn) and Scandium (Sc) elements were found to have good biocompatibility and biodegradability; hence, they were selected as suitable alloying elements for magnesium.

This research work aims to enhance the mechanical integrity and bio-corrosion resistance behaviour of a novel Mg-1wt% Zn-0.5wt% Sc cast alloy by laser shock peening surface treatment with multiple passes (LSP-2 Pass and LSP-3 Pass). …

Fantasy Novels, Romance, And Book Boyfriends: Romantic Views And Expectations Of Young Adult Women, Kennedy Dawn Morris

Theses and Dissertations

Despite its drop in popularity, reading is a pastime that is enjoyed by many. As with other forms of media, there is the question of how consuming literature impacts individuals. This research study examines how reading fantasy novels impacts the romantic views and expectations of women in emerging adulthood. Social comparison theory and parasocial relationships were utilized in order to examine how young adult women compare their relationships and relationship ideals to those of fictional characters, as well as how young adult women decide which fictional relationships and/or characters are worth their admiration. The findings of this study suggest that …

The Use Of Culturally Responsive Mentor Texts For Literacy Development In An Elementary Classroom, Ashley Vernon

Theses and Dissertations

The purpose of this study was to examine the effectiveness of Culturally Responsive Mentor Text in literacy development in an elementary classroom. Students in this study demonstrated increases in overall literacy development in the areas of comprehension and verbal discourse when paired with Culturally Diverse texts throughout the study. This study revealed that students were able to make more connections with texts and increase discussion when recognizing unfairness and overcoming struggles.

Applying Ceragenins In Translational Medicine: Activating Mesenchymal Stem Cells And Preventing Healthcare-Associated Infections, Aaron L. Zaugg

Theses and Dissertations

Healthcare-associated infections are a major global concern. Increased infections among vulnerable populations lead to millions of deaths, annually, complicated by the emergence of multi-drug resistant pathogens. These infections are often facilitated by medical devices serving as abiotic surfaces that facilitate the formation of biofilms. Notably, colonization of prostheses and other bone-associated medical devices can lead to corrective procedures, revisions and death. To address these issues, inspiration can be drawn from natural sources of bone health and defenses against infection. Cathelicidins are endogenous peptides involved in both bone maintenance and infection control. Ceragenins are small molecule mimics of cathelicidins with broad …

The Cellular Mechanisms Of Alzheimer's Disease Protection By The Pilra G78r Variant, Wenhan Cheng

Theses and Dissertations

Microglial dysfunction is increasingly linked to Alzheimer’s Disease (AD). Immune receptors like TREM2 and CD33 play opposing roles in microglial activity. TREM2 activation triggers immunoreceptor tyrosine-based activation motif (ITAM) signaling to promote microglial activities, including amyloid-β clearance, but variants in TREM2 such as R47H that impair its function increase AD risk. In contrast, CD33 is an inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) which transmits signals that suppress microglial function. An AD-protective variant in CD33 alters CD33 activity, potentially enhancing TREM2 function. PILRA is another inhibitory immune receptor expressed by microglia that contains an ITIM. A naturally …

Implications Of The Mind’S Active Participation In The Formation Of Perception, Maikel Adel Samy Michael

Theses and Dissertations

The mind-body problem, particularly the issue of qualia, remains a fundamental challenge in understanding the nature of the mind and its relation to the body. In this thesis I argue that the problem is epistemic, stemming from how we perceive and know ourselves as physical and mental beings. This argument will be explored through the respective of idealisms proposed by George Berkeley and Immanuel Kant. Berkeley's idealism suggests that reality is rooted in perception, offering a major steppingstone by demonstrating the major role perception plays in understanding and acquiring knowledge. Kant contributes by asserting that the "thing-in-itself" is beyond our …

“Perfect Hearts And Pure Pages”: The Transmission And Recitation Of The Qur’An In Mamluk Cairo—The Shāṭibiyya As A Case Study, Jonathan Hearn

Theses and Dissertations

The Ḥirz al-Amānī wa-Wajh al-Tahānī of Abū al-Qāsim b. Fīrruh al-Shāṭibī (d. 590/1193) became one of the most widely studied texts associated with the recitation of the Qur’an. A didactic versification of Abū ʿAmr al-Dānī’s (d. 444/1053) Kitāb al-Taysīr fī al-Qirāʾāt al-Sabaʿ, the Shāṭibiyya was composed in Ayyubid Egypt and transformed the discipline of the variant readings (qirāʾāt). Despite its popularity and acknowledged impact upon the discipline, the Shāṭibiyya remains a relatively untapped resource for understanding the Qur’an in its recited form. This thesis studies the recitation of the Qur’an in Mamluk Cairo through the Shāṭibiyya, …

Future Of Work: Implication Of Green Economy On Employment Dynamics In Egypt, Sarah Adel Elgohary

Theses and Dissertations

Is Egypt's green economy a reality or just a policy-level aspiration? This thesis explores the tangible impact of the green economy on Egypt's labor market by examining key sectors—automotive, agriculture, and renewable energy. Through qualitative interviews and focus group discussions with private sector representatives, the study assesses the true implications of the green transition from a business-level perspective, beyond the propaganda and hype surrounding climate policies. What is the current scale of the green economy in Egypt's labor market? What existing policies and regulatory frameworks are in place to support the green economy transition? how urgent is the transition to …

The Social Standing Versus The Mind Standing Of Older Adults In Egypt: Cross-Sectional Analysis Of The Relationship Between Social Capital And Cognitive Functions, Shaza H. Shinaishen Dr

Theses and Dissertations

Introduction: Egypt's population, much like that of other countries, is expected to age considerably over the course of the coming decades. Although biological and socioeconomic predictors of cognitive function have been studied widely, personal level social capital remains unexplored, especially in LMICs.

Purpose: This study primarily investigates the relationship between individual social capital and cognitive functioning among older adults aged 65 years and older in Egypt using the structural and cognitive components of social capital, including group membership, civic engagements, and caregiving roles.

Methods: A cross-sectional survey on 363 older individuals in different geographical and demographic segments of Egypt using …

Ways Of Living And Knowing, Reem El Hassan Mohamed

Theses and Dissertations

After decades of sedentarization, the Muzeina tribe in South Sinai now has new generations born into sedentary lifestyles, never experiencing nomadism like their ancestors once did. This shift has impacted their knowledge system, traditionally shaped by interactions and kinship with nature. Exposure to social media is influencing younger generations' ways of living, raising the older generations’ concerns about their Bedouin identity. Despite being one of the largest tribes in South Sinai, the Muzeina are rarely represented in literature.

This ethnography explores the impact of sedentarization and contextual developments on the Muzeina's knowledge system, inherited from their ancestors. Muzeina’s relationship, and …

Exploring The Role Of Religious Media In Shaping Public Perceptions Towards Climate Change In Egypt, Hebatullah Ashour Abdel Fatah Ibrahim Ashour

Theses and Dissertations

Climate change poses significant threats globally, with particular vulnerability noted in developing nations like Egypt. While effective communication is crucial for societal engagement, the role of influential actors like religious media within specific cultural contexts remains under-explored. This thesis investigates the role and communication practices of religious media (Islamic and Coptic Christian) concerning climate change in Egypt, a country where religious institutions command significant public trust and influence. Existing literature highlights gaps in understanding how these specific media outlets navigate and frame climate change discourse.

Employing Framing Theory and Communication for Development (DevCom) Theory as a combined framework, this study …

Hierarchy Viz: A Visual Analytics Framework For Visualizing Hierarchical Data Using Machine Learning, Vinay Kumar Uppalapati

Theses and Dissertations

Automated visualization systems aim to generate visualizations directly from raw data with minimal user inputs. However, while existing systems focus on data visualizations mainly using line charts and scatter plots to explore the data patterns, they struggle with hierarchical data representation where data relationship is essential. Hierarchical visualization, crucial for understanding multi-level relationships, typically requires users to manually define hierarchies and have expertise in visualization tools to create meaningful representations. This makes the process complex, time-consuming, and reliant on domain knowledge. To address this, we propose HierarchyViz, an automated system that detects multiple hierarchies in raw datasets and generates intuitive …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …

Exploring Consequences Of The Double Empathy Problem Across The Autistic Trait Spectrum: First Person Accounts, Cammy C. Peck

Theses and Dissertations

Historically, individuals on the autism spectrum were believed to have deficits in empathy. However, recent research suggests that empathy-related issues occur on both sides of the communication dynamic. This concept known as the Double Empathy Problem (DEP), posits that the perceived lack of empathy is not exclusive to autistic individuals; rather, neurotypical (NT) individuals also experience difficulty empathizing with autistic individuals (Milton, 2012). Milton et al. (2022) describes this as a "breakdown in mutual understanding". Such mutual misunderstanding can have adverse consequences for both autistic and neurotypical individuals. To our knowledge, no studies have directly examined these consequences in relation …

The Effect Of Personalized Profiles On Generating Customized Content In Artificial Intelligence Augmentative And Alternative Communication Devices, Rachel Johnson

Theses and Dissertations

With advancements in artificial intelligence (AI), several augmentative and alternative communication (AAC) devices have begun incorporating AI with the purpose of accelerating and improving message transmission for users. The results have shown that AI can significantly reduce a user's keystrokes, but the generated responses may lack personalization. The objective of this study was to investigate whether integrating a personalized profile containing user information enhances the perceived accuracy and personalization of AI generated messages. Various methods of collecting profile information and differing levels of information within the profile were evaluated. One hundred eighty-one neurotypical English-speakers with no history of language disorder …

Mechanisms Underlying Estrous Cycle-Dependent Changes In Incubated Cocaine Craving, Erin Elizabeth Wannen

Theses and Dissertations

Cues associated with cocaine use are one of the most common relapse triggers and understanding what promotes cue-induced cocaine craving and relapse is a critical question in the field. Human studies have shown that these measures are impacted by fluctuations in ovarian hormone levels, as higher levels of estradiol promote cue-induced cocaine craving in women while higher levels of progesterone reduce craving in both sexes. Enhanced or incubated cue-induced cocaine seeking or craving also changes across the rodent reproductive (estrous) cycle as levels of estradiol and progesterone fluctuate, with enhanced seeking behavior observed during the estrus stage of the cycle. …

Modeling The Mark 26 Guided Missile Launching System: Exploring Its Role In U.S. Naval Doctrine In The Late Cold War, Ryan Matthew Cabico

Theses and Dissertations

The Mark 26 Guided Missile Launch System was an innovative and modular upgrade from previous systems for the United States Navy at a critical development point during the Cold War. Its incorporation into the Virginia-Class, especially the USS Arkansas, exemplified the rapidly evolving scope and demands of naval warfare in the modern era, and the requirements of individual vessels and component parts of the Navy to fulfill U.S. naval doctrine in this era. This same rapid evolution in technology and the global political landscape would ultimately seal the fate of the Mark 26 and USS Arkansas, with their designed innovations …

Exploring Soft Polymeric Nanoparticles For Targeted Biomolecule Delivery In Plant Cells, Mohammad Rashid

Theses and Dissertations

Safe and efficient agricultural practices require innovative technologies. Nanotechnology offers promising solutions for advancing plant agriculture by enabling the targeted delivery of biomolecules such as agrochemicals and nucleic acids. This study focuses on developing a safe nanotechnological approach for delivering molecules of interest into plant cells. We investigated the ability of four types of polymeric nanoparticles such as Polyethylene glycol N, Nʹ-dibutylethylenediamine (PEG-DB), Polyethylene glycol 2-pyrrolidin-1-yl-ethyl-amine (PEG-PY), Polyethyleneimine (PEI), Arabinoxylan (AX)+, and Zein+ to form conjugates with plasmid DNA (pDNA). Our findings confirm that plant-derived cationic nanopolymers, AX+ and Zein+, effectively bind negatively charged pDNA (pGFPGUSPlus) carrying a GFP reporter …