Lonidamine Is A Novel Inhibitor Of Fatty Acid Oxidation, Tianhai He

Theses and Dissertations

In this thesis project, we examined the hypothesis that lonidamine is an effective inhibitor of FAO in mammalian cells, underling its inhibitory effects on bioenergetic production and anti-cancer action. We compared its effects on FAO and glycolysis in multiple human cancer cell lines of different lineages.

Math Leaders’ Perceptions Of Social Justice Pedagogy: Implications For Professional Development On Teaching Mathematics For Climate And Environmental Justice, Angela M. Allen

Theses and Dissertations

Two significant crises facing communities of color are climate and environmental injustices (Schlosberg & Collins, 2014) and the achievement gap in standardized test performance as an impact of inequitable educational experiences rooted in a history of social inequities (Agarwal, 2011; Milner, 2020). Previous studies on teaching mathematics for social justice demonstrate positive student outcomes from this practice (Berry, 2008; Gutstein, 2006). Existing literature also points to benefits when focusing on a specific social justice topic during mathematics instruction (Bartell, 2013; Stocker, 2012). However, few studies focus on math leaders’ perceptions of teaching mathematics for climate and environmental justice (TMCEJ).

This …

Chloroplast Genome Evolution In The Klebsormidiophyceae And Streptofilum, Sarah Glass

Theses and Dissertations

The Klebsormidiophyceae are a class of green microalgae found globally in both freshwater and terrestrial habitats. Morphology-based classification schemes of this class have been shown to be insufficient, particularly due to the simple morphology of these algae, the tendency of morphology to vary in culture versus in field conditions, and rampant morphological homoplasy. Molecular studies revealing cryptic diversity have renewed interest in this group. We sequenced the complete chloroplast genomes of taxa in the Klebsormidiophyceae representing the known taxonomic breadth of this class, as well as the chloroplast genomes of three strains of Streptofilum, a recently discovered algal lineage …

The Dutch Atlantic And American Life: Beginnings Of America In Colonial New Netherland, Roy J. Geraci

Theses and Dissertations

The Dutch colony of New Netherland was one of the earliest attempts at a non-indigenous life on the east coast of North America. That colony, along with the United Provinces of the Netherlands and Dutch Atlantic as a whole, played crucial roles in the development of what would become the United States. This thesis project examines the significance New Netherland held in American history as well as explores topics which allow for new and inclusive narratives of that history to reach further exploration. Similarly to how individuals from various cultures, ethnicities, and backgrounds all come to exist amongst one another …

Biomass-Derived Electrode Materials And Sustainable Processes For Supercapacitors, Katelyn M. Shell

Theses and Dissertations

Biomass is one of the most abundant natural resources and has been used as a source of energy for thousands of years. Biomass as a precursor for energy storage materials is still relatively novel and faces several obstacles before becoming commonly used in today’s electrical devices. Currently, energy storage devices, such as batteries, capacitors, and supercapacitors, utilize petroleum-derived graphitic carbons for anodes, generating a need for more sustainable materials. Biomass, as a carbon-rich source for electrode materials, presents a viable and economically feasible alternative due to the prevalent lignocellulosic compounds: lignin, cellulose, and hemicellulose. Preliminary studies on the solid residues …

Reducing Produced Water Disposal Via Effective Treatments Methods And Re-Use: Proposed Sustainable Application For Bakken, North Dakota, Olusegun Stanley Tomomewo

Theses and Dissertations

It is true that the advancements in both the hydraulic frack and directional drilling technologies led to less time and a bit easier ways to develop unconventional oil and gas assets worldwide. In the Bakken North Dakota, the result of these breakthroughs and advancements in technologies are that they drastically reduce the time it takes to drill and complete a well leading to more wells (347 in 2004 to 16,300 in 2020). In 2019, the United States became the largest global crude oil producer, and the unconventional Bakken Play in North Dakota is one of the major contributors to this …

Understanding The New Wealthy: Ideologies, Consumption Patterns, And Organizational Strategies For A New Generation Of High-Net Worth Individuals, Ana Brant

Theses and Dissertations

Despite the fact that the Ultra High-Net Worth (UHNWI) belong to the wealthiest, most powerful, and influential group of consumers in the society, and nearly 70% created wealth on their own, current marketing approaches fail to consider what drives consumption behavior of this group of consumers and how can brands maximize their socio-economic impact. Across two studies, I develop a model that guides theory and practice regarding this consumer group. The first part of the first study deployed netnography and grounded theory to understand the ideologies of 30 self-made UHNWI derived from self-presentation on 3,393 Instagram posts. To ensure self-made …

Best Practices For Non-Profit Organizations Using Human-Animal Interaction As An Intervention With At-Risk Youth, Jai Oni Sly

Theses and Dissertations

Non-profit organizations and community programs work with at-risk youth to teach social-emotional skills like empathy, self-confidence, and self-efficacy. This research aimed to examine best practices for community programs that use human-animal interaction as an intervention for at-risk youth. Specifically, the phenomenological study aimed to review the successful strategies that community programs when working with the at-risk youth population. The challenges faced and how these type of community programs measure their success were also important purposes of these research. Participants shared successful strategies, how success is measured as well as challenges and recommendations for other community programs that work with the …

As Honorable As Tears: Comedy As Surgeon, Pharmacist, And Clown, Emily S. Rauch

Theses and Dissertations

No abstract provided.

A Systematic Review Of The Literature On Post-Traumatic Growth In Police Officers After Exposure To Potentially Traumatic Events, Michael Norfleet

Theses and Dissertations

As police departments and officers across the world take on the task of reducing crime and enhancing public safety, their jobs entail the potential of exposure to events that may be experienced as traumatic. In contrast to the larger literature on negative outcomes of potentially traumatic events (PTEs), there is limited knowledge on the potential for post-traumatic growth (PTG) and how clinicians can promote it, generally and in police officers (Westphal & Bonanno, 2007). Tedeschi and Calhoun (1996), “coined the term posttraumatic growth to describe the experience of positive changes that occur as a result of the struggle with major …

What Sound Reveals To Our Eyes: The Intersection Between Subconscious Thought And Real Imagery In Experimental Film And Sound Design, Mireille G. Heidbreder

Theses and Dissertations

The impetus for making films that conjure up atemporal, interconnected spaces suggestive of a unique reality has been influenced in large part by Michel Foucault’s idea of heterotopia, or the creation of a new world by joining together discursive spaces. As such, my practice begins with the collection and re-imagination of these discursive spaces through a combination of an in-depth exploration of little-known landscapes and the organic observation of the natural realm in relation to the human world. By combining various mixed media including digital, film print, as well as re-purposed archival footage, I alter the filmic quality of the …

Development Of Analytical Methods For Analysis Of Glycosaminoglycans And Their Mimetics In Human Plasma, Rawan M. Fayyad

Theses and Dissertations

Glycosaminoglycans (GAGs) are linear, polydisperse polysaccharides consisting of alternating amino sugars and either a uronic acid or galactose residue. They are ubiquitous components of the extracellular matrix and are present on cell surfaces and in basement membranes. GAGs are highly negatively charged as a result of many sulfate and carboxylic acid groups, and are extremely heterogeneous in both their structure and in their physicochemical properties. This complexity in structure is attributed to the alterations in residue types, glycosidic bond linkage, sulfation levels, sulfation positions, and chain lengths during biosynthesis. GAGs interact with a wide number of proteins and modulate various …

Ties That Bind Us, Christine M. Orr, Christine M. Orr

Theses and Dissertations

when objects converge in a space

they start a dialogue of their lives

lives that become entangled with your life

your memory

objects are the narrators of memory

a stain, a chip, a tear

materials embed meaning and metaphor within the process of creating

woven cloth, throwing lines, squeezed and pressed coils

all become remnants of the hand

as I make, play, and collect materials and objects

questions are brought forward

How do these components talk to one other?

What are they saying?

How do I listen?

knowledge is generated in the transformation of material through the process of

making …

Regulation Of Osseous Healing By Macrophage-Derived Wnt Ligands, Jefferson Overlin Abaricia

Theses and Dissertations

Osseous healing is regulated by various classes of cells and signaling mechanisms. Of these, Wnt signaling has long been known to be critically important in directing the differentiation of mesenchymal stem cells (MSCs) into osteoblasts during bone healing. However, the source of these Wnt ligands is not known. Recently, a body of literature has arisen finding both beneficial and detrimental effects of macrophage-derived Wnt ligands on the regeneration of other tissues (liver, kidney, heart, and intestine), often by regulating inflammatory activation and stem cell behavior. As macrophages have been well-characterized as orchestrators of healing, their use of Wnt signaling to …

Bullying Prevention And Social Justice: Recommendations For Teachers, Anna Grigorian-Routon

Theses and Dissertations

Though bullying was once considered a "rite of passage," in recent years experts have begun to re-conceptualize bullying as an imbalance of power between the bully and the victim and to recognize the deleterious mental health outcomes that are often the result of having experienced or having participated in bullying. This phenomenon is also coming to be viewed more broadly as a human rights violation as it creates and perpetuates barriers for specific student populations to equal access to education. Historically, teachers have been among the most outspoken advocates of social justice issues and are on the front lines of …

The Rurality Of Education: Best Practices To Improve The Quality And Accessibility Of Basic Education Service Delivery In The Rural Area Of Oke Ogun, Oyo State In Nigeria, Alice Jokodola

Theses and Dissertations

Nigeria’s educational system is riddled with issues and challenges, leading it to have the highest number of out-of-school children in the world. Not only have these issues and challenges led to a high number of out-of-school children, but it has also led to an increase in national poverty and illiteracy rates. Research points to the fact that these challenges result from a lack of quality and accessible basic education in Nigeria. It also indicates that rural areas are often the most vulnerable and affected when it comes to receiving quality and accessible education. This study focused on the rural area …

Giving Voice To Everyday Characters In Extraordinary Circumstances, Andrew D. Hasselbring

Theses and Dissertations

Giving voice to everyday characters in extraordinary circumstances -- Undesirable donor -- Blowfish -- Behind the lavender door

Evolving Perspectives: How Research, Age, And A Global Pandemic Alters The Mind's Eye In Costume Design, Audrey Reed

Theses and Dissertations

This thesis explores how various factors can affect how something is viewed and appreciated. It specifically relates to James and the Giant Peach the musical as it is as a halted production for the VCU theatre due to COVID-19. This document encompasses facts about Roald Dahl’s life, details about my designs for the production, as well as how a global pandemic affected the life of theatre. Included in this document are research and renderings.

The Therapeutic Potential Of Glycosaminoglycan Directed Metalloglycomics: Elucidating New Targets And Mechanisms For Polynuclear Platinum Complexes, James D. Hampton

Theses and Dissertations

Cancer remains a serious clinical problem and in order to continue to improve patient health outcomes, novel treatment strategies must continue to be developed. Platinum chemotherapies remain as one of the most widely successful classes of cancer therapeutic, with over 50% of cancer patients receiving a platinate at some point over the span of their treatment. However, intrinsic and extrinsic resistances limit their effectiveness, long term efficacy, and broad applicability to multiple cancer subtypes. Therefore, the development of new agents and strategies which can overcome these limitations are crucial for patient health. To this end a novel class of polynuclear …

Preclinical Pharmacokinetic Studies Of Pterostilbene, And Its Human Pharmacokinetic Prediction Using Physiologically Based Pharmacokinetic Modeling, Palak S. Phansalkar

Theses and Dissertations

This dissertation research aimed to determine the preclinical pharmacokinetics of pterostilbene in vitro and develop a physiologically based pharmacokinetic (PBPK) model to simulate the animal and human PK profiles for pterostilbene. The in vitro PK characteristics of pterostilbene, including Caco-2 cell permeability, plasma protein binding, and metabolic stability were determined using rat and human intestinal & hepatic S9 subcellular fractions. The in vitro metabolic parameters determined in rat subcellular fractions were extrapolated to in vivo values to predict the oral bioavailability (F_oral) in rats. The predicted F_oral was found to be 43.0 %, which is similar to …

Searching For Gold: Using A Novel Land Cover Classification To Identify Multiscale Drivers Of Site Occupancy By A Flagship Species For Early-Successional Habitat Conservation, Baron Lin

Theses and Dissertations

Understanding habitat selection at multiple scales is an important step in guiding conservation programs and reversing species declines. This, however, is difficult for species that occupy early-successional habitats (ESH) due to a lack of accurate representation of shrub cover in publicly available land cover data. The Golden-winged Warbler (Vermivora chrysoptera; GWWA) is a threatened species of conservation concern and a flagship for ESH conservation. We used a novel, LIDAR-derived land cover classification that accurately identifies shrubs at a fine resolution (1m) to investigate how habitat composition and configuration influence GWWA site occupancy. We aggregated this same land cover …

Owning Our Story: An Interior Exploration To Foster Self-Reflection, Hannah Bulow

Theses and Dissertations

With emerging technologies in the 21st century, Millennial and Gen Z adults have a complicated relationship with these new technologies when it comes to creating and sustaining personal relationships (Dalessandro, 2018). When persons aged 18-35 forged new relationships without the presence of technology, relationships were more organic, natural, and led to less conflicts. Neuroimaging of the brain has also shown that neurocognitive development during early adolescence and adulthood contributes to self-consciousness and vulnerability. Adolescents are called to develop their own identity separate from their parents and understanding how others are actually evaluating them (Sebastian, 2008)

Brene Brown states that most …

Structural Reorganization Of The Cisternal Organelle In Neuroinflammatory Disease, Myshak S. Abdi

Theses and Dissertations

The axon initial segment (AIS), an axonal sub compartment located immediately distal to the soma, is an important structure in mediating action potential generation and modulation. The morphology of this domain can be altered by a wide variety of activity-dependent, environmental, and pathological triggers. Dysregulation of axonal calcium (Ca²⁺) concentrations, and subsequent enzymatic degradation of AIS cytoskeletal architecture have been reported to underlie structural modifications of the AIS. Moreover, pharmacological inhibition of neuronal Ca²⁺ channels have been shown to mitigate the disruptive effects of neuroinflammation on AIS structural integrity. Here we investigate the Cisternal Organelle (CO), a …

Radioimmunoconjugate For Cancer Molecular Imaging, Nouri Elmekharam

Theses and Dissertations

Over expression of Sperm Acrosomal SLLP1 Binding protein (SAS1B) on the surface of uterine cancer and the availability of different anti-SAS1B monoclonal antibodies (mAbs) that specifically bind to it, offered an opportunity to label these antibodies with radionuclides for cancer imaging. Although optimizing in vivo stable radiolabeling is challenging, imaging this type of aggressive cancer will improve the treatment strategy. The objective of this work is to develop a radiolabeled anti-SAS1B antibodies with Zircunum-89 (⁸⁹Zr) and Copper-67 (⁶⁷Cu) and determine, in vitro and in vivo their uptake and biodistribution. Two anti-SAS1B monoclonal antibodies (SB2, and SB5) …

Copper Sulfide Manganese Nanoparticles For Multimodality Imaging And Therapy, Ali S. Gawi Ermi

Theses and Dissertations

Abstract

COPPER SULFIDE MANGANESE NANOPARTICLES FOR MULTIMODALITY IMAGING AND THERAPY

By Ali S. Gawi Ermi, MSc

Inorganic nanoparticles (NPs) are compatible with metal-based multi-modality molecular imaging and targeted therapy. Copper sulfide nanoparticles (CuS NPs) are attractive photoacoustic and photothermal agents and are amenable to incorporation of radionuclides and paramagnetic elements to facilitate image-guided therapy. The aim of this work is to develop manganese (Mn)- doped CuS NP, intrinsically radiolabeled with radionuclides such as (Zirconium-89 (⁸⁹Zr), Copper-64/67 (^64/67Cu) and Manganese-52/55 (^52/55Mn)). This novel approach combines Photoacoustic (PA), Positron emission tomography (PET), Single-photon emission computed tomography …

A Mechanism Behind The Mechanotransduction Of Surface Characteristics In Osteoblasts, Otto J. Juhl Iv

Theses and Dissertations

Biomaterials for use in bone regeneration and healing range from metal and metal alloy implants to hydrogel-based solutions. These materials can be optimized to increase bone healing and integration by improving the mechanical and biological properties. Regardless of the material itself, the cell-substrate interaction is key to the success of the biomaterial once implanted. Substrate surface characteristics such as roughness, wettability, and particle density are well-known contributors to a substrate’s overall osteogenic potential, and therefore the substrate's overall success. Unfortunately, it is still unknown how these substrate surface characteristics are transduced into intracellular signals by cells, preventing specific tailoring of …

Grief, Loss, And Climate Change: Validation Of A Solastalgia Scale, Claire Luce

Theses and Dissertations

Climate change has been identified as a defining issue of this century (United Nations, n.d.). Climate change impacts human wellbeing including mental health. While much research has focused on the way that the effects of climate change cause increases in common mental disorders, mental health is not just the absence of these disorders (World Health Organization, 2014). Non-pathologized mental health responses to climate change, such as the grief and loss that results from climate change impacts, are a growing consideration for researchers. Solastalgia, or the distress experienced in the absence of the solace once provided by the environment in the …

Beyond The Social: Artist Project Spaces, 2003 To 2016., Clare L. Van Loenen

Theses and Dissertations

This research examines storefront project spaces in the early 2000s that offered alternative approaches to the programming, organizing, and archiving found in conventional museums. I propose that such sites impacted participatory visual culture by offering a reformulatory role for arts’ practices, one that organized itself across disciplinary boundaries, chose a collaborative rather than competitive approach, and processed the ideological implications of their group work. Focused on three specific sites—Machine Project in Los Angeles, Elsewhere in Greensboro, and Mess Hall in Chicago—this study details the museological, pedagogical, and archival challenges of these artist-convened organizations. My interdisciplinary investigation offers a reference point …

The Algorithmic Mashrabiya: Reimagining The Traditional Islamic Screen, Ahmed Nour

Theses and Dissertations

Traditionally, a mashrabiya was an ornate wooden structure attached to the side of an Arabian building or house, with small, intricately patterned openings to provide both ventilation and privacy for the people inside. The patterns, following the geometric rules of Islamic ornament, lent a distinctive appearance to buildings in the region. A mashrabiya converted the house into a safe, private sanctuary, providing a magical scene inside, characterized by linear sun rays, filtered points of light and shadow. Over time, as building technology changed and the number of skilled craftsmen dwindled, the traditional mashrabiya has all but vanished. The aim of …

The Living Theatre Of Horror: Examining How Centuries Of Western Theatrical Practice And Theory Inform The Modern-Day Haunted House, Scott Dittman

Theses and Dissertations

This work will discuss the growing modern phenomenon of theme park and regional haunt events in the United States. In it, we will explore the history of how horror has been presented on stage, the themes within horror that creators grapple with, and how by using traditional theatrical elements creators of modern haunt events are able to make the audience a part of the story, transforming them from passive observers of the scenarios presented to complicit participants. How does the history of horror theatre inform the production of modern haunt events (and how has a global pandemic affected them), what …