Digital Commons Network^™

A Rho5-Cnc1-Dnm1 Signalling Module Coordinates Multi-Organelle Execution Of Regulated Cell Death In Yeast, Justin Bauer

Theses and Dissertations

Regulated cell death is a conserved process with major implications for health and disease, yet how yeast cells integrate stress signals to determine survival versus death remains unclear. This thesis investigates Cyclin C (Cnc1), a conserved Mediator kinase module component with both transcriptional and mitochondrial roles. Together with Cdk8 Cnc1 primarily represses stress response genes, while upon stress it translocates to the mitochondria to induce mitochondrial fragmentation with the dynamin-related GTPase Dnm1. Using structure-guided separation-of-function mutants, I demonstrate that Cnc1-dependent death requires its mitochondrial function rather than its transcriptional role, and that its effector Dnm1 acts as a signaling node …

Anatomy And Function Of Vasopressin Receptor 1a-Expressing Neurons In The Limbic Thalamus, David Joseph Kahn

Theses and Dissertations

The vasopressin (Avp) system modulates social behavior through region-specific and sex-dependent mechanisms, yet the role of Avp receptor 1a (Avpr1a) signaling in the thalamus has remained largely unexplored. This dissertation examined the distribution and functional contributions of Avpr1a-expressing neurons across the mouse thalamus using a combination of genetic labeling, anatomical quantification, and chemogenetic manipulation. Mapping of Avpr1a-expressing neurons revealed a presence in most thalamic nuclei, with highest densities in the anterior thalamic nuclei and midline nuclei. Notably, Avpr1a-expressing neuron densities did not mirror previously described patterns of Avp innervation, and no sex differences in Avpr1a-expressing neuron density were observed. Chemogenetic …

Filling The Knowledge Gap: The National Automobile Theft Bureau And The Rise Of Private Intelligence, 1912–1941, William Murray

Theses and Dissertations

This thesis examines the Automobile Protective and Information Bureau (APIB) and its successor, the National Automobile Theft Bureau (NATB), situating these institutions within the development of corporate intelligence in the United States. The rapid expansion of automobile ownership produced a form of crime defined by technological advancement and jurisdictional fragmentation that existing law enforcement could not effectively address. In response, automobile insurance companies created the APIB as a centralized clearinghouse for theft intelligence. By standardizing reporting, maintaining national records, and distributing investigative information, the Bureau developed an early private intelligence infrastructure that supported law enforcement. The limitations of local enforcement …

Integrative Assessment Of Body Composition And Micronutrient Status In An Adult Egyptian Population, Roua Aref Nouh

Theses and Dissertations

Integrative Assessment of Body Composition and Micronutrient Status in an Adult Egyptian Population: A Functional and Biochemical Approach

Obesity and metabolic dysfunction are increasingly recognized as heterogeneous conditions that cannot be sufficiently characterized by body mass index (BMI) alone. Alterations in body composition, particularly central adiposity and skeletal muscle mass, may coexist with micronutrient imbalances even among individuals who fall outside conventional BMI-based obesity classifications. In clinical settings, such metabolic vulnerability is frequently accompanied by non-specific functional symptoms, highlighting the need for integrative assessment approaches that extend beyond weight-centered metrics. This cross-sectional study aimed to investigate the associations between micronutrient …

Philosophia From Dialectic To Dying Before Death: Traces Of Plato’S Spirit In The Encounters Between The Falāsifa, Mutakallimūn, And Sūfiyya, Fadhil Yunus Alsagoff

Theses and Dissertations

This thesis offers a fresh approach to the question “What is philosophy?” by reconsidering Plato’s vision of philosophiaand seeking its traces in the encounters between the Falāsifa, the Mutakallimūn, and the Sūfiyya of the classical Muslim world. I argue that Plato’s true legacy lies in a vision of philosophia as dialectical inquiry that ultimately leads – due to the inextricable limitations of propositional language – to aporia and what he called “practicing for dying and death.” I then argue that this vision of philosophia finds resonance in the classical Muslim world in the embodied encounters between …

"I'Ve Just Re-Read The Aeneid Again": Virgil's Thematic Influence As Depicted In Katabatic Journeys In The Fiction Of C. S. Lewis, Henry Young

Theses and Dissertations

Inspired by his studies in Classical, Medieval, and Renaissance literature, C. S. Lewis incorporated echoes of Virgil in his fiction, especially in katabatic journeys. In his scholarship, he identified Virgil's Aeneid as "secondary epic" which contains the Christian-like theme of vocation in the face of transition. Traces of this theme are evident in Lewis's fiction, expressed through mythical katabatic imagery. Katabasis, for Lewis, appears as a Pagan pattern fulfilled in Christ and experienced by His disciples through conversion. Lewis's characters, though ordinary people, must learn to accept divinely given vocations which then propel them into katabatic sequences that inspire belief …

The Use Of Artificial Intelligence In Enhancing Arabic Regional Tv News Stations, Engy Mohamed Elzakazeky

Theses and Dissertations

Arabic regional TV news stations have started using artificial intelligence (AI) as a tool for facilitating journalism work, coping with technology, and engaging audiences, as a result of the digital transformation in the television industry. This study examines how Arab regional TV news stations are incorporating AI into their operations, including its uses, opportunities, and limitations, in its early stages, through in-depth interviews with 14 media professionals in 13 Arab news stations. By reflecting on their own experiences, a purposive sample of news editors, managing editors, and graphic designers employed by news channels were interviewed. These media professionals were able …

Readiness Before Adoption: Exploring Ai Integration In Egyptian Nonprofit Fundraising, Marwa Y. Zayed

Theses and Dissertations

 Abstract

Artificial intelligence (AI) has been transforming fundraising through data-driven decision-making, automation, and personalized donor engagement. Existing research focuses on AI applications and outcomes in the nonprofit sector in western context, with little known information in the Global South, particularly Egypt. This gap makes understanding the organizational conditions that shape AI difficult and limited. This thesis examines how organizational, cultural, ethical, and resource-related factors shape Egyptian nonprofit organizations’ readiness to adopt AI in fundraising. Through a qualitative approach, semi-structured interviews were conducted with 21 fundraising directors, CEOs, a governmental representative, and technology professionals working in Egyptian nonprofits based in Cairo …

Mapping The Neuroexposome: Integrative Analysis Of Dementia Risk Factors Through Multi-Omics And Environmental Profiling In The Egyptian Population., Mai Ahmed Saadzaghloul Othman

Theses and Dissertations

Background: Dementia represents one of the most pressing public health challenges of the twenty-first century, with the global burden projected to reach 153 million cases by 2050. Egypt, as the most populous Arab nation, faces a corresponding rise in age-related diseases, yet comprehensive data from low- and middle-income countries remain severely limited. The neuroexposome framework, integrating genetic susceptibility, environmental exposures, and metabolic alterations, offers a powerful strategy to characterize the complex interplay between internal and external risk factors for Alzheimer's disease (AD) and Alzheimer's disease Related Dementias (ADRD).

Objectives: This thesis aimed to: (1) examine the distribution of APOE alleles …

An Integrated Sensor-Fusion Framework For Performance-Based Compensation In Construction, Aly Ayman El-Ashry

Theses and Dissertations

Construction productivity has historically stagnated due to a reliance on subjective labor monitoring and “lagging” performance indicators. This research proposes a novel compensation model with the use of Total Energy Management System (TEMS) to translate labor effort and efficiency into payment incentives with the integration of Internet of Things (IoT) wearables and Statistical Process Control (SPC) charts.

This research addresses the systemic problem of declining construction productivity caused by industry’s inability to objectively quantify human effort. While traditional models rely on post-facto production tallies, a significant research gap exists in real-time physiological labor monitoring. To bridge this, the proposed TEMS …

Documenting Death: A Question Of Sovereignty In The Cairo Geniza, Thomas Adkins

Theses and Dissertations

How can death offer a case study for the question of sovereignty in eleventh to thirteenth century Egypt as it was performed by sovereigns, officials, and subjects alike, and, in this context, how can the documentary practices preserved in the Geniza be understood as an instrument to perform sovereignty? This thesis uses death as a case study in the same way that scholars of the medieval Islamic world have studied taxation, administration, and ceremonials to understand sovereignty as it was performed by the state, officials, and subjects. This performance of sovereignty by each implicated actor left a rich documentary trail, …

Effects Of A Complexity-Based Approach For Treatment Of Be Verbs In Children With Developmental Language Disorder: A Single-Case Design, Megan Shawnee Rowe

Theses and Dissertations

The purpose of this study is to examine whether a complexity-based treatment approach improves the production of BE verb structures in a child with developmental language disorder (DLD). One school-age child with morphosyntactic deficits participated in a single-case AB experimental design. Treatment targeted a complex structure (auxiliary BE questions), and performance was measured using experimental probes, a narrative language sample, and the Test of Early Grammatical Impairment (TEGI). Results indicate a functional relationship between treatment and increased accuracy of the treated structure, with a medium effect size (τ = .695, p = .019). In addition, the participant demonstrated generalization to …

Evaluating C-Band Scatterometer Images For Estimating Deforestation In The Amazon Rainforest, Alex Mcbride

Theses and Dissertations

Satellite-based active microwave sensors have been successfully employed for a wide range of vegetation and soil studies. Spaceborne microwave instruments have proven particularly useful for wide-scale monitoring of the vegetation, especially under conditions that limit the effectiveness of high-resolution optical sensors. Satellite scatterometry can be used to detect and model deforestation in the Amazon rainforest by correlating changes in the C-band backscatter data to observed changes in vegetation coverage. The exploratory methodology developed in this paper applies the longest continuous microwave satellite record to the problem of deforestation. The backscatter measurements taken by the ERS and ASCAT missions provide more …

U.S. Black Men’S Perceptions Of The Similarities And Interplay Among Mind-Body Practices, Spirituality, And Religion: A Qualitative Study, Khanh Pham

Theses and Dissertations

This qualitative study explored U.S. Black men’s perceptions of relations among mind-body practices (MBPs), spirituality, and religion to understand how these factors might influence Black men’s health. Reflexive thematic analysis was used to analyze data from individual semi-structured interviews with 18 Black male MBP instructors. Five themes were generated. The themes were (1) spirit(uality) is the foundation for Black men’s experience of life seen and unseen, (2) MBPs and religion are rooted in spirituality, (3) MBPs, religion, and Black culture share common characteristics, (4) MBPs and religion facilitate holistic wellbeing, and (5) confusion and negative perceptions about MBPs, spirituality, and …

Viewing Machines, Janos Cseh

Theses and Dissertations

By sifting through personal memories, the contemporary media landscape, and seeing the world through the lens of painting, Cseh asks what it means to understand information through images.  The artist unpacks the interwoven relationships between images and memory, feeling and seeing, and the difficulty of seeking truth through an analysis of his paintings.

Discovery Of Bmi-Associated Gut Microbiome Signatures In The Awi-Gen 2 Cohort, Meriem Yagoubi

Theses and Dissertations

Obesity is increasing across sub-Saharan Africa amid rapid dietary, environmental, and urbanization transitions, yet the gut microbiome features associated with adiposity in African populations remain under-characterized. This study investigated whether species-level gut microbiome composition is associated with body mass index (BMI) in the AWI-Gen 2 cohort, and whether BMI-associated microbial signals remain detectable after accounting for the dominant geographic structure of the microbiome. Gut microbiome community structure and diversity were characterized across 1,665 participants, and differential abundance analysis was used to identify taxa associated with BMI after controlling for study site. Machine learning models were then trained to assess how …

The Impact Of Student Choice On Reading Engagement And Comprehension In First Grade, Gia Stella Nardi

Theses and Dissertations

The purpose of this study was to (a) examine the effect of student choice on first-grade students’ reading engagement and (b) determine how student choice impacted their reading comprehension during instruction. Throughout the study, students utilized a choice board following each read-aloud to express their understanding of what they perceived as important in the text. Findings indicated that students demonstrated high levels of engagement during the 12 read-alouds, which were intentionally selected based on their interests, as well as during the choice-based activities that followed. Additionally, students showed growth in their ability to apply key comprehension skills, including summarizing, identifying …

Effects Of Divided Attention On Linguistic Tasks And Speech In Healthy Young Adults, Allison Coca

Theses and Dissertations

The purpose of this study was to determine the effects of divided attention on concurrent speech and linguistic tasks by investigating performance on three linguistic computer tasks (phonological, syntactic, and semantic) and speech kinematics. Thirty-seven healthy young adults (19 male, 18 female) ages 19-30 were recorded performing a sentence repetition task using electromagnetic articulography. Each participant completed the sentence repetition once in isolation and once concurrently with each of the three linguistic computer tasks. Participants also completed computer tasks in isolation. Significant dual-task effects were observed on total number of correct responses in the phonological and syntactic linguistic tasks. No …

Spatiospectral Lobes And Radiation Modeling Of Partially Coherent Supersonic Jet Noise, Tyce Wayne Olaveson

Theses and Dissertations

Noise fields generated by high-performance military jets are known to contain acoustic structures that differ from their simulated and lab-scale counterparts. These differences may limit current noise control efforts, which are designed and tested at scale before being considered for full-scale aircraft. One such noise structure is the presence of spatiospectral lobes, which appear as multiple spectral peaks at single microphone locations and multiple radiation lobes in field reconstructions. This dissertation uses data collected from the T-7A jet noise measurement to characterize the spatial behavior of the spatiospectral lobes as well as their first time-domain description. A multiple wavepacket decomposition …

Investigation Of Environmental Influences On Multiple Sclerosis: A Study For Egypt’S Health, Noha Ezzaldin Alziny Ali

Theses and Dissertations

Background: Multiple sclerosis (MS) is a complex, chronic neuroinflammatory disease influenced by both genetic and environmental factors. While global research has identified potential environmental influences, most evidence comes from Western populations, creating a significant knowledge gap for regions like Egypt, which has witnessed a dramatic rise in MS prevalence over recent decades. This study hypothesized that Egyptian MS patients exhibit a distinct biological signature in their blood, characterized by an imbalance in essential and toxic trace elements (the metallome) and alterations in stress-response biomarkers associated with neuroaxonal injury and cellular stress. Objective: This study aimed to comprehensively profile and compare …

Environmental And Pharmacological Modulation Of Opioid-Mediated Behavioral Effects In Rats, Corinne Ann Gallagher

Theses and Dissertations

Opioid Use Disorder (OUD) and opioid-associated overdoses continue to pose significant burden to US healthcare systems—both financially and in lives lost. It is imperative to identify risk factors which may predispose vulnerability to OUD development, which could aid in discovery of new therapeutic strategies for susceptible populations. This dissertation investigated the impacts of two such risk factors which modulate opioid-induced reward and behavioral effects: adolescent stress and the adulteration of illicit opioids by xylazine. In Chapter 2, we examined the effects of acute adolescent stress on oxycodone self-administration in rats, and the potential involvement of the locus coeruleus in these …

The Correlation Between Perceptual Abilities And The Acquisition Of Non-Native Consonant Clusters, Hope Emma Nielson

Theses and Dissertations

A common approach in the study of speech motor learning is to have speakers learn to produce clusters of consonants that do not occur in their native language. This study investigated the relationship between auditory or speech perceptual abilities and the initial acquisition of non-native stop-stop consonant clusters. Sixty young adult participants (56 female, four male) were administered a gap detection test and a speech-in-noise test to assess their innate perceptual skills. The participants then performed a nonsense-word repetition task featuring non-native consonant clusters in the initial position. The participants' spoken productions of the nonwords were recorded and analyzed acoustically …

Weekly Published Magazine Covers During World War Ii: Cover Photos Used To Represent The Wartime Experience, Annika B. Larson

Theses and Dissertations

Weekly published magazines served largely as news outlets during World War II, and the images on the covers of these magazines were not only an attention catcher and tone setter, but were images chosen to represent the ever-changing landscape both on the homefront and internationally. In addition, these publications often used photographs that represented the developments their allies and enemies were making in tandem with domestic coverage. The entities publishing the magazines were managed by both the government and independent civilians, dependent on the country, thus providing different views of the war. The coverage in the United States and United …

Rethinking Functional Groupings In Basketball Wings Through Ecological Trait Frameworks, Dhruv Mehrotra

Theses and Dissertations

This paper starts with a review about Plant Functional Types and then goes deeper into the conceptual foundations of Plant Functional Types (PFT's) with detailed discussion of global trait spectra such as the leaf economics spectrum and the fast-slow continuum. Using concepts like response and effect traits, the review then talks about how a trait based ecological framework can provide a more robust guideline to classify plants. The review then talks about how players in basketball have been classified in the past along with some of the newer typologies. The review starts to draw some parallels between the ecological framework …

Injectable, In Situ Forming Peptide Nanofiber Reinforced Composite Hydrogels For Age-Related Macular Degeneration, Shambhavi Bagewadi Ms

Theses and Dissertations

Cell therapy for age-related macular degeneration (AMD) is limited by the absence of a functional substrate such as Bruch’s membrane (BM), which is critical for retinal pigment epithelial (RPE) cell survival and integration. Although preformed substrates have been explored, their implantation can disrupt the fragile retinal architecture, compromise ocular immune privilege and increase infection risk. To address these limitations, an injectable hydrogel capable of forming in situ was developed. The hydrogel consists of thiol-modified hyaluronic acid (HA-SH) and polyvinyl alcohol (PVA). Peptide nanofibers were incorporated to enhance structural reinforcement. Three self-assembling peptides - RADA-16, GAGA and GAGA-YIGSR were designed and …

The Effects Of Phonetic Knowledge And Bilingualism On The Acquisition Of Non-Native Consonant Clusters, Kylie Wakley

Theses and Dissertations

Speech motor learning involves the production of new sounds or sound sequences. This study investigated how explicit phonetic knowledge and bilingualism affect how individuals acquire sound sequences that do not occur in English, or non-native consonant clusters. Sixty adults with typical speech, aged between 18 and 27 years, participated in the experiment. The researcher recruited participants into four groups based on their phonetic background (experienced or not) and language background (monolingual, bilingual). The participants produced stop-stop and fricative-nasal clusters in the initial position of nonsense words across six practice blocks. The duration of each cluster was measured, which in English …

Oxidized Lipids Are Inflammatory Danger Signals. The Hydrolytic Enzyme Carboxylesterase 1 Regulates Their Metabolic Fate, Thereby Shaping Macrophage Phenotype., Oluwabori Adekanye

Theses and Dissertations

Macrophages originate from hematopoietic progenitors they are immune cells, part of innate immunity. They patrol tissues to identify damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) from microorganisms. Macrophage pattern recognition receptors (PRRs) detect these signals, and respond by secreting lipid mediators, cytokines, and chemokines, thereby initiating the inflammatory response. Carboxylesterases (CES) belong to the α/β-hydrolase fold family of proteins and catalyze the hydrolysis of ester-containing substrates into alcohols and carboxylic acids. CES1 is one of the six CES identified in the human genome. They are localized in the endoplasmic reticulum lumen and cytosol of cells, primarily expressed in …

Impacts Of Structural Design On Oyster Survival And Predation In Restored Oyster Reefs, Jaden Akers

Theses and Dissertations

Restoration efforts are critical to ensure healthy oyster populations, but the high cost and marginal success rate of many restoration efforts demonstrates the need to evaluate alternative oyster reef restoration designs and strategies. To address this issue, I conducted a paired field and mesocosm study to assess the influence of structural design on oyster survival and predation. Results of the field portion of this study showed that oyster survival was greatest in short and bed-level (i.e., sitting on the sea bottom) reef designs. When assessing how design features impact oyster drill activity, elevated reefs (i.e., elevated above the sea bottom) …

How Did A Pandemic Impact Park Usage Among The Older Adult Populations In Memphis, Tn?, Katherine Barlow

Theses and Dissertations

During COVID-19 older adults’ populations were a vulnerable demographic, and through a review of existing literature it was determined that there is limited research about park and outdoor space use during COVID-19 by older adults. This research seeks to address these gaps by examining how a pandemic impacted park usage among the older adult population (age 60+) in Memphis, TN at Shelby Farms Park. This study examines the comparison of park use during (2020-2023) and after (2023-present) COVID-19. A mixed methods approach was employed. Wilcoxon Signed Rank test was run to analyze the survey data and a significant statistical difference. …

Community Development Professionals’ Perceptions Of Agritourism In Mississippi, Emma Jane Berry

Theses and Dissertations

Agritourism has emerged as a strategy for supporting rural economies, strengthening community identity, and increasing agricultural literacy. Although prior research has examined agritourism operators and visitors, limited attention has been given to the perceptions of community development professionals who influence local planning and program support. The purpose of this qualitative exploratory study was to examine community development professionals’ perceptions of agritourism’s role in community development, economic growth, and agricultural literacy in Mississippi. Guided by Social Exchange Theory, data were collected through two semi-structured virtual focus groups with 12 professionals representing Extension, tourism, economic development, and Main Street organizations. Data were …