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Methodological Mutability: Shifting Research In The Rhetoric Of Health And Medicine, John Schuler Benson Iii

Theses and Dissertations

The Rhetoric of Health and Medicine (RHM) is a growing body of scholarship that pulls from technical communication, rhetorical theory, and a number of other disciplines to inquire about the capacities of rhetoric at the intersection of medical practitioners and scholars, the medical humanities, and the publics they inform and treat. Among RHM scholars there is a consensus that the field’s methodological diversity is one of its greatest strengths; indeed, field leaders articulate one of RHM’s exigencies as “encouraging methodological collaboration and experimentation” (Melonçon and Scott, Methodologies 4). This dissertation takes up these calls with the introduction of shifting, a …

Sensory Processing In Male Children With Fragile X Syndrome And Idiopathic Autism: Implications For Maladaptive Behavior And Within-Syndrome Heterogeneity, Chandler Knott

Theses and Dissertations

Proficient sensory processing affords adaptive responses that are necessary for daily functioning. Atypical sensory processing patterns are common across neurodevelopmental disorders, including autism spectrum disorder (ASD) and fragile X syndrome (FXS), two disorders with a high degree of phenotypic overlap. However, little is known about whether types of atypical sensory processing in FXS vary as a function of genetic etiology or the presence of ASD. Atypical sensory processing has been also associated with maladaptive outcomes in certain clinical populations; however, the impact of these impairments on internalizing and externalizing behavior remains unknown in FXS. Study participants included 37 male children …

Sex Differences And Potential Non-Invasive Treatments For Calcific Aortic Valve Disease, Henry Pascal Helms

Theses and Dissertations

Calcific Aortic Valve Disease (CAVD) is a progressive heart disease that ranges from aortic valve sclerosis to aortic valve stenosis. It is characterized by intense calcification and compromised valve function. CAVD affects 25% of people older than 65 and 50% of people older than 85. These rates are expected to increase in the United States due to higher levels of obesity and diabetes, as well as an aging population. CAVD is the leading cause of valve replacement surgery. Annual healthcare costs for these valve replacements are currently estimated to be approximately 2 billion dollars. There are currently no medications approved …

Mechanisms Of Connectivity In Neuronal Development, Janay Vacharasin

Theses and Dissertations

The development of neuronal connectivity requires the careful orchestration of multiple cellular processes including the control of neuronal arborization and synapse formation or function. Defects in these processes during neuronal development will give rise to disorders of neuronal connectivity like autism. In the present work, we examine the genetic and epigenetic mechanisms that build the neuronal wiring of the developing brain. We use human stem cell-derived neurons to study neuronal arborization and function focusing on genetic and environmental risk factors of neurodevelopmental disorders that include autism and intellectual disability. Specifically, we focused on the contribution of the endomembrane, chromatin, and …

The Devil And Tom Robot: The Use Of Robotics To Impact Empathy In Secondary Students Of American Literature, Susan K. Porter-Voss

Theses and Dissertations

The purpose of this action research study was to evaluate the effect of a robotics-based intervention on empathy for students enrolled in secondary English and literature courses. Empathy, as a concept, is an integral component of reading comprehension and student motivation. A decline in reported individual levels of empathy among young adults can negatively influence longitudinal academic and career success. Robotics present a promising method in which to impact student learning in K-12 environments. Student manipulation of Wonder Workshop Cue robots in designed challenges was integrated within literature content standards for English III. The outlined study measured the impact of …

Using Multimedia Vocabulary Games To Improve Newcomer Esol Students Motivation And Vocabulary Acquisition, Elizabeth E. Brittingham

Theses and Dissertations

This study looks at the use of the multimedia learning platform, Quizlet, to help newcomer ESOL students learn English vocabulary. The use of Quizlet to learn vocabulary is supported by Mayer’s Cognitive Load Theory. With an influx of ESOL students, and a lack of teacher training, Quizlet may help to create a more equitable solution for newcomer ESOL students to learn English vocabulary. The findings of this study show that newcomers benefit from using Quizlet to learn vocabulary in the language 2 by matching it to the vocabulary in the language 1, but only if they are able to read …

Effects Of Positive Social Comparative Feedback During Practice On Motor Sequence Learning, Performance Expectancies, And Resting State Connectivity, Allison Foster Lewis

Theses and Dissertations

Positive social comparative feedback indicates to the learner that they are performing better than others. While this type feedback supports motor skill learning in some tasks, the effect of social comparative feedback on motor sequence learning remains unknown. In addition, the OPTIMAL theory predicts that positive social comparative feedback may trigger a dopaminergic response in the brain. However, no studies have utilized neuroimaging techniques to investigate this question. Therefore, the aim of these studies was to determine the effect of positive social comparative feedback on motor sequence learning, performance expectancies, and resting state connectivity of dopaminergic neural pathways.

In the …

Mechanisms And Impact Of Hypoxia Regulated Inhibins In Cancer, Ben Allen Horst

Theses and Dissertations

Inhibins are heterodimeric ligands within the TGFβ superfamily, comprised of an α-subunit (INHA) and a β-subunit (either INHBA or INHBB) with emergent roles in cancer. Inhibins are biomarkers of disease burden and prognosis in a subset of cancers and utilize the coreceptors betaglycan (TGFBR3) and endoglin (ENG) for physiological or pathological outcomes. Previously, we found inhibin promotes angiogenesis in ovarian cancer however no mechanism of regulation for inhibin expression in cancer has been established. Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. …

In Vivo And In Vitro Investigations Of Mammalian Stem Cell Development: Neurogenesis And Pituitary Progenitors, Allison Culver

Theses and Dissertations

Human development is tightly regulated by complex mechanisms to pattern the early embryo and form specialized tissues. Understanding this regulation is of fundamental importance and can help further understand disease pathologies. Because it is difficult to observe the processes of interest, researchers must rely on the use of model systems. Our research goal is to combine both animal models and in vitro stem cell cultures to address key questions about the mechanisms of development for both the pituitary gland and brain. It is estimated that there are 290-455 cases per million of congenital hypopituitarism. In addition, autism spectrum disorder (ASD) …

Molecular And Morphological Investigations Of Grouper (Serranidae) Biodiversity In Saudi Arabia, Mohammad Saeed Al Jazza Alqahtani

Theses and Dissertations

Chapter 1: The seas surrounding the Arabian Peninsula, which represent the northernmost portion of the Indian Ocean, are considered to have the highest aquatic biodiversity among the worlds marine regions. Seas that surround the Arabian Peninsula include the Red Sea, the Gulf of Aden, the Arabian Sea, the Gulf of Oman, and the Arabian Gulf. In aggregate, this area harbors a large number of endemic and more widespread marine species, including fishes, echinoderms, and corals.

There are unique challenges involved in grouper species identification in the Arabian region including ‘familiar’ Arabic species designations that are not standardized in the Arabic …

Africanizing The Curriculum: African Diaspora Literacy Instruction In Elementary Classrooms, Jarvais Javon Jackson

Theses and Dissertations

Using a Critical Case Study design, this study examines the implementation of African Diaspora Literacy (ADL) in three elementary classrooms in order to understand successes, challenges, and student outcomes. African Diaspora Literacy (ADL) refers to becoming literate about African Diasporic peoples, histories, cultures, languages, epistemologies, cosmologies, and axiologies (King, 1992; Boutte et. al., 2017). Against the backdrop of worldwide and systemic anti-Black racism--the most dominant and virulent form of racism (Dumas & Ross, 2016), there is a need for instructional and curricular antidotes in K-12 schools and in the academy (Boutte et. al., 2017). African Diaspora Literacy offers a promising …

Crystal Growth Of Inorganic Halides And Oxide-Halides For Scintillation Applications And Radiation Detection, Gyanendra B. Ayer

Theses and Dissertations

Scintillators, materials which emit light when struck by high energy X-rays and y- rays, are extensively used in various fields including medical imaging, computed tomography, high-energy physics, and more recently in homeland security for the prevention of nuclear and radiological terrorism. While comparing with the traditional scintillators, which have long-term instability, high synthetic cost, toxicity, and hygroscopicity issues, metal halides have been reported to exhibit effective excitonic radioluminescence and greatly contribute in the field of scintillating applications and radiation detection. Currently, the mixed-anion oxide-fluorides have emerged as a prospective new class of scintillators, in which the mixed oxide-fluoride environment …

Transcranial Alternating Current Stimulation As An Adjuvant For Nonfluent Aphasia Therapy: A Proof-Of-Concept Study, Lynsey Mcgrath Keator

Theses and Dissertations

Identifying effective and efficient rehabilitation tools is crucial to improve language outcomes for persons living with chronic aphasia. Speech entrainment has proved to be particularly successful in improving speech output in nonfluent aphasia. It is hypothesized that, for patients with aberrant oscillatory synchronization between anterior and posterior language regions of the left hemisphere, speech entrainment may act as an external gaiting mechanism to bolster an impaired efference copy and improve synchrony between these regions. Theoretical and empirical evidence supports this idea that speech production relies on anterior-posterior connectivity in the left hemisphere.

Transcranial alternating current stimulation (tACS) delivers low, periodically-alternating …

Role Of Epigenome In Regulation Of Inflammation By Ahr Ligands 2,3,7,8-Tetrachlorodibenzo-P-Dioxin And 6-Formylindolo[3,2-B] Carbazole, Alkeiver Cannon

Theses and Dissertations

Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver mediated by immune cells and characterized by a variety of parameters including circulating autoantigens, elevated immunoglobulin G (IgG) and aminotransferases, and interface hepatitis. Unfortunately, despite treatment with broadly immunosuppressive drugs, the disease progresses to cirrhosis and end-stage liver disease in several cases. In order to develop a more specific treatment, the mechanisms governing the liver injury resulting from inflammation and autoimmunity need to be elucidated.

For decades, activation of Aryl Hydrocarbon Receptor (AhR) was excluded from consideration as a therapeutic approach due to the potential toxic effects of AhR …

Mass Spectrometric Investigation Of Removal/Transformation Of Emerging Contaminants For Safer Potable Wastewater Reuse, Kristin Cochran

Theses and Dissertations

Water scarcity is of increasing global concern as rising demand depletes current sources, so other sources such as potable wastewater reuse are being utilized. Advanced wastewater reuse removes pathogens and many contaminants, but there are concerns about resistant contaminants and the transformation products that are generated during the treatment process. This research focuses on several different contaminant classes, how well they are removed via advanced treatment processes, what transformation products arise from both advanced treatment and chlorination disinfection, and how those treated waters may impact health via toxicity and estrogen activity.

Contaminant classes considered are illicit drugs, pharmaceuticals such as …

Association Between Postpartum Weight Retention And The Dietary Inflammatory Index, Nyrobi Tyson

Theses and Dissertations

Objective: The objective of this thesis is to examine the relationship between the Dietary Inflammatory Index (DII), measured during the postpartum period, and postpartum weight retention.

Setting and Participants: We used the Infant Feeding Practices Study (IFPS) II (n=5000), a longitudinal study of women from late pregnancy through their infant’s first year of life conducted between 2005 and 2007. Survey topics included feeding practices, infant health, food allergies, sleeping arrangements, mother’s employment, childcare, and mother’s dietary intake.

Main Outcomes: Postpartum weight retention (PPWR) was calculated in kilograms by subtracting self-reported body weight at 3, 6, 9, and 12 months postpartum …

The Impact Of An Interactive Simulation Program On English Language Learner Achievement In A Middle School Science Classroom, Scott Sutherland

Theses and Dissertations

The purpose of this study was to determine how a particular technology program, Gizmos, would impact English language learner students in demonstrating their verbal and written comprehension of science content at a proficient level. Gizmos were incorporated as an intervention to facilitate the teaching of two different topics, convection cells and hurricane motion. This study involved three English language learner students with varying World-Class Instructional Design and Assessment (WIDA) proficiency levels between one and four. Semi-structured interviews, semi-structured observations, and work samples were conducted and collected from each of the participants. My analysis demonstrated a strong correlation between the use …

Methyltransferase Mystery: Epigenetic Mechanisms Induced By Food Limitation In Daphnia Pule, Trenton C. Agrelius

Theses and Dissertations

Daphnia are ecologically important organisms that have been well studied in the context of evolution, ecology, ecotoxicity, and genomics. Daphnia have strong maternal effects in which the environment experienced by the mother can alter offspring disease resistance, life history traits, and morphology, as well as gene expression and methylation for multiple generations. Coupled with their ability to reduce genetic differences via parthenogenesis, Daphnia are an ideal system for epigenetic studies involving the transmission of maternal effects. Using two clones of Daphnia pulex, we investigated the plasticity of life history and DNA methyltransferase (Dnmt) gene expression with respect to food …

Hybrid Theory-Machine Learning Methods For The Prediction Of Afp Layup Quality, Christopher M. Sacco

Theses and Dissertations

The advanced manufacturing capabilities provided through the automated fiber placement (AFP) system has allowed for faster layup time and more consistent production across a number of different geometries. This contributes to the modern production of large composite structures and the widespread adaptation of composites in industry in general and aerospace in particular. However, the automation introduced in this process increases the difficulty of quality assurance efforts. Industry available tools for predicting layup quality are either limited in scope, or have extremely high computational overhead. With the advent of automated inspection systems, direct capture of semantic inspection data, and therefore complete …

Detection Of Microcystin Aerosol Particles, Alexis D. Dabney

Theses and Dissertations

Harmful Algal Blooms (HABs) are a growing global concern due to their increased prevalence and magnitude, frequency, and duration in affecting both aquatic ecosystems and human health (Brooks et al. 2015). In a series of experiments, lab-generated aerosol particles containing Microcystis and Microseira were captured using filters to analyze for concentrations of Microcystin, Saxitoxin, and Lyngbya toxins. The solutions were found to contain aerosols but did not contain detectable levels of Microcystin, Saxitoxin, and Lyngbya toxins following analysis by HPLC-MS. While the techniques for generating aerosols were shown to be effective, the generation and analysis of toxins did not produce …

Unearthing An Emerging Neglected Bacterial Disease: Evidence Of Spotted Fever Group Rickettsioses In El Salvador, Kyndall Christian Braumuller

Theses and Dissertations

The main objectives of this dissertation were to investigate the seroprevalence of Spotted Fever Group Rickettsioses (SFGR) antibodies in a specific vulnerable population at high risk for vector-borne disease in El Salvador, understand the relevant risk factors for SFGR past and acute infection in this same population through logistic regression modeling, and clarify the presence of SFGR bacteria in locally collected ticks.

SFGR are a group of bacterial diseases caused by species in the Rickettsia genus of the phylogenetic spotted fever group. These are tick-borne diseases (TBD) that have been described in almost every region of the world. SFGR are …

Electro-Mechanical Data Fusion For Heart Health Monitoring, Kemal Yakut

Theses and Dissertations

Heart disease is a major public health problem and one of the leading causes of death worldwide. Therefore, cardiac monitoring is of great importance for the early detection and prevention of adverse conditions. Recently, there has been extensive research interest in long-term, continuous, and non-invasive cardiac monitoring using wearable technology. Here we introduce a wearable device for monitoring heart health. This prototype consists of three sensors to monitor electrocardiogram (ECG), phonocardiogram (PCG), and seismocardiogram (SCG) signals, integrated with a microcontroller module with Bluetooth wireless connectivity. We also created a custom printed circuit board (PCB) to integrate all the sensors into …

The Telsam Protein Polymer Significantly Improves The Speed And Propensity Of Crystallization Of Target Proteins, Seyedeh Sara Soleimani

Theses and Dissertations

While conducting pilot studies into the usefulness of fusion to TELSAM polymers as a potential protein crystallization strategy, we observed novel properties in crystals of two TELSAM–target protein fusions, as follows. (i) A TELSAM–target protein fusion can crystallize more rapidly and with greater propensity than the same target protein alone. (ii) TELSAM–target protein fusions can be crystallized at low protein concentrations. This unprecedented observation suggests a route to crystallize proteins that can only be produced in microgram amounts. (iii) The TELSAM polymers themselves need not directly contact one another in the crystal lattice in order to form well-diffracting crystals. This …

Development Of Enhanced Food Packaging Systems Based On Blends Of Bio-Based And Biodegradable Polymers Exhibiting Antimicrobial Properties, Aishat Agboluaje

Theses and Dissertations

Food packaging is one of the important aspects of food processing, which contributes greatly to decreasing post-harvest food losses. While ensuring that foods are adequately packaged, it is also important to consider the impact of these food packaging materials on the environment. Accordingly, this research work was aimed at investigating the potential of bio-based and biodegradable blends of polyvinyl alcohol (PVA) and chitosan loaded with antimicrobial agents such as turmeric, clove, and cinnamon for use in food packaging applications. The methodology involved creating PVA/chitosan films with varying compositions via solvent casting method and selecting the best composition exhibiting the highest …

Home-Shared Reading Influences On Phonological Awareness Abilities Of Primary Students Who Experienced An Interruption Of Classroom Literacy Instruction Due To A Catastrophic Event, Alisa Maxine White

Theses and Dissertations

This qualitative study was conducted to explore emergent literacy and phonological awareness abilities of primary students who experienced an interruption of classroom literacy instruction due to a catastrophic event. Participants included four primary students and their parents. The students participated in home-shared reading regularly and missed the last nine weeks of classroom instruction during their pre-kindergarten or kindergarten school year due to a catastrophic event. The participants were observed during home-shared reading. Three research questions were used to explain the study: 1) When children are read to at home and miss the last nine weeks of school, what phonological behaviors …

Consequences Of Microsporidian Prior Exposure For Virus Infection Outcomes And Bumble Bee Host Health, Elyse Christine Mccormick

Theses and Dissertations

Host-parasite interactions do not occur in a vacuum, but in connected multi-parasite networks. Resulting co-exposures and coinfections during an individual host’s lifetime can affect host health and infectious disease ecology, including disease outbreaks. However, many host-parasite studies examine pairwise interactions, meaning we still lack a general understanding of the influence of co-exposures and coinfections. Using the bumble bee Bombus impatiens, we study the effects of larval exposure to a microsporidian Nosema bombi, implicated in bumble bee declines, and adult exposure to Israeli Acute Paralysis Virus (IAPV), an emerging infectious disease from honey bee parasite spillover. We hypothesize that infection outcomes …

Biomimetic Strategies To Control Therapeutic Release From Novel Dna Nanoparticles, Robert J. Mosley

Theses and Dissertations

The inherent chemical, mechanical, and structural properties of nucleic acids make them ideal candidates for the formulation of tunable, personalized drug nanocarriers. However, none so far have exploited these properties for the controlled release of therapeutic drugs. In this dissertation, a biomimetic approach to controlling drug release is exhibited by specifically manipulating the architecture of novel, DNA nanoparticles to take advantage of drug binding mechanisms of action. Rationally designed DNA strands were immobilized on gold surfaces via a terminal thiol modification. Immobilized monomers can be manipulated to form distinct monolayer architectures including flat, folded, coiled, or stretched structures. Increasing the …

Lowering The Technological Barrier In Developing, Sharing And Installing Web Gis Applications, Rohit Kumar Khattar

Theses and Dissertations

Portability of web applications between web servers of different organizations can be challenging and can complicate sharing and collaborative use of such tools. Given the distributed nature of the web, this lack of portability is usually not a concern because a user in one organization can link to and use a web application hosted by another organization. However, access control or differentiation may be needed by an organization in terms of area of interest, input data, analytical techniques, access control, presentation, branding, and language. This is true for many government organizations, and their associated web sites, and servers. In such …

The Apostrophic Impasse: Diacritical Remarks On The Stories Of International Law, Legal Decolonial Genealogy And Antony Anghie’S Historiography, Britt L.A.Q. (Haadiya) Hendrix

Theses and Dissertations

The (hi)stories of international law have strengthened the tentacles of coloniality in the legal regime as they continue to taunt the precarious lifeworlds of people, our planet and social imaginaries of an otherwise. The flow of coloniality has similarly rematerialized in decolonial legal theories and the postcolonial historiographical accounts of international law. I intend to demonstrate this colonial revival in the groundbreaking text of Antony Anghie Imperialism, Sovereignty and the Creation of International Law (2005) which challenged the (hi)stories of traditional jurisprudence. The latter was not necessarily a rejection nor negation of Western thought, because I argue that postcolonial historiography …

Ethical Considerations Concerning The Dignity Of Patients With Terminal Disabling Illness, Hebatallah Rashed

Theses and Dissertations

Almost everyone agrees that they should be treated and treat others in a dignified manner; however, people have different views about dignity and what gives people honour and worth. There are different philosophical ideas about the meaning of this concept and its conditions. The concept of human dignity has been a fundamental yet controversial area in the field of bioethics, especially with the ongoing debate over euthanasia.

The aim of this thesis was to evaluate different philosophical views about the concept of dignity, and how the evolution of this concept throughout history affected our understanding of the moral permissibility of …