Digital Commons Network^™

Cb1 Allosteric Modulation: Preclinical Insights Into Therapeutic Potential And Misuse Liability, Mohammed A. Mustafa

Theses and Dissertations

Cannabinoid type-1 (CB1) allosteric modulators represent a promising approach to modulate CB1 receptor signaling by binding to distinct receptor sites, without producing adverse cannabimimetic and dependence-related effects associated with Δ9-tetrahydrocannabinol (THC) and other CB1 agonists. This dissertation investigates the pharmacological, behavioral, and dependence-related profiles of CB1 allosteric modulators for their therapeutic potential and misuse liability. Presented here, the chiral CB1 positive allosteric modulator (PAM) ZCZ011 was resolved into its R- and S-enantiomers and characterized across in vitro and in vivo assays. Both enantiomers enhance CB1 agonist activity and produce intrinsic effects in vitro. Behaviorally, they produce antinociceptive effects in the …

Algorhythm: Commodification Of Hobbies On Social Media Platforms, Fariha Ahmed

Theses and Dissertations

Forcing the world online, the COVID-19 pandemic appeared to turn social-media-based hobbies into income-generating cash cows. Digital creative spaces became sites of capitalist logic where hobbyists came to operate as both laborers and commodities. Profit-focused algorithms operate imperceptibly, shaping creative behavior and decision-making in ways that are difficult to recognize, and even harder to resist. This thesis asks how algorithmic participation on platforms such as Instagram conditions a hobbyist, and how that conditioning can be made legible to audiences who inhabit such platforms without always seeing them. Using autoethnography, I position myself as both researcher and subject to document the …

From Cultural Binaries To Coexistence: A Graphic Autoethnography Of Individualism And Collectivism In An International Context, Shahad Alsubaie

Theses and Dissertations

This arts-based autoethnographic study investigates individualism and collectivism, specifically through my study-abroad experience traveling from Saudi Arabia to the United States. Through arts-based reflective practice, I depicted the diasporic experience of being ontoepistemologically collectivistic while navigating a primarily individualistic society. I use the medium of a graphic memoir to illustrate and develop frameworks of confluence that embrace the two distinct cultural orientations simultaneously. This arts-based self-study not only contributes to the body of transnational scholarship but also serves as a reference for international students, researchers, and educators to use arts-based subgenres and data analysis methods to gain better insights into …

Tried For A Flower And Made The Sun, Megan Koeppel

Theses and Dissertations

My thesis work celebrates natural color, honors traditional hand processes, and gently questions the often gendered divisions between different material disciplines. I emphasize the continued relevance of these ancient tacit traditions through exposed seams and stitches. I create a color palette entirely derived from plants and insects, sharing the many shades that come from natural dyes. I create wall mounted and installation based works that soften the edge of distinction between painting, sculpture and textile.

My research includes the history of soft sculpture and American quilting, paired with the stories and chemistry of natural color. With a process closely related …

Contours Of Duration: Movement Authored Through Form—A Behavior Archive, Jood Senussi Elbeshti

Theses and Dissertations

Insect anatomy offers an elegant example of motion derived from structure. Inspired by insect movement, Contours of Duration employs a cam-and-follower system consisting of moving, leg-like parts, designed to engage a series of rotating cams, such that the shape of each cam’s surface activates the legs in unique ways, generating repetitive movement, and demonstrating how geometry produces distinct motion behaviors over time. Through iterative experimentation and controlled variation, trace emerges as a central methodology, whereby movement, over time, creates a distinct pattern of marks, making motion legible and reflecting how subtle changes to surface and form generate different behavioral outcomes. …

Dietary Acculturation, Dietary Inflammatory Potential, And Metabolic Syndrome Among Immigrants In The United States: A Mixed-Methods Approach Using Nhanes And Qualitative Data, Esse G. Foka Nzaha

Theses and Dissertations

Background and Objectives: Immigrants in the United States undergo acculturation — a process of sociocultural and behavioral adaptation to the host country. Increasingly, behavioral adaptations have been associated with cardiometabolic health and chronic disease risk. Metabolic syndrome (MetS), a cluster of conditions including abdominal obesity, elevated blood pressure, impaired fasting glucose, elevated triglycerides, and reduced HDL cholesterol, is a major risk factor for type 2 diabetes mellitus, cardiovascular diseases and other chronic diseases, including cancer. Despite the growing immigrant population in the U.S., the role of diet and dietary acculturation in MetS development remains poorly understood in this population. This …

24-H Circadian Rest-Activity Rhythms And Physical Frailty In Older Adults: A Biopsychosocial Perspective On Sex Differences And Social Capital, Jisu Kim

Theses and Dissertations

Physical frailty is a prevalent geriatric syndrome characterized by age-related decline across multiple physiological systems. Physical frailty is associated with an elevated risk of adverse health outcomes, including chronic disease progression and all-cause mortality, representing a significant and growing public health concern. Disrupted circadian rest-activity rhythms (RARs) are increasingly recognized as clinically meaningful markers of physical frailty in older adults. However, the extent to which biological sex and social determinants of health (SDoH), particularly social capital, contribute to or modify the associations between RARs and physical frailty remains underexplored.

Therefore, this dissertation summarizes the existing literature on age-related changes in …

Mediator: Ornament As A Visual Language Of The Transcendent, Selma Fejzullaj

Theses and Dissertations

Adolf Loos’s declaration that “ornament is a crime” defined modernist design, establishing a legacy that dismisses ornamentation as wasteful and regressive. This research questions that legacy by repositioning aesthetics as a divinely grounded value, inspired by the Qur’anic vision of Paradise. In this celestial realm, beauty is not wasteful but a manifestation of divine perfection. Conceptually, the project reclaims ornament as a vital tool for contemplating metaphysical themes. Materially, it reimagines glass, shifting it from modernist "radical honesty" to a medium of layered depth. Recombining traditional Islamic ornamentation practices such as Girih and Chaharbagh, the project evokes the Qur’anic vision …

Local Lung Delivery Of Ginkgetin For Therapeutic Intervention In Lung Fibrosis, Cimone L. Richardson

Theses and Dissertations

Lung fibrosis (LF) is a progressive, irreversible pathological condition in the lungs that is ultimately fatal. Current drug treatments (nintedanib, pirfenidone, and nerandomilast) slow disease progression but cause significant systemic adverse effects due to oral administration. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, may play a role in LF progression and represent a novel anti-LF target. Ginkgetin (GKT), a natural biflavonoid, is a potent TRPV4 inhibitor with anti-inflammatory and antioxidative properties. Local lung delivery could achieve high local lung concentrations while minimizing systemic exposure. Accordingly, this project evaluates GKT's therapeutic intervention efficacy in LF via local lung …

Discrete Cell Signaling Differences Cause Female-Dominant Il-33 Responses In Mast Cells, Tania D. Maldonado

Theses and Dissertations

Many allergic diseases are more common and severe in women than in men. A key component of allergic inflammation is IL-33, a cytokine released by epithelial cells after allergen exposure. Because mast cells are a central early responder in allergic disease and are activated by IL-33, we investigated sex differences in mast cell responses to IL-33. We first found that male mast cells expanded poorly in standard RPMI-based culture media containing phenol red, which has estrogenic properties. Male cells also responded poorly to IL-33 when cultured with in media containing phenol red. In contrast, female mast cells expanded 3-fold less …

Climate, Biogeography, And Dispersal: A Unifying Framework For Ameri-Caribbean Dry Forests, Pablo Lopez Bustamante

Theses and Dissertations

Seed dispersal is a crucial ecological function that enables plants to alter their distributional range, avoid intense competition and natural enemies near the parent plant, and recover from disturbances. These processes shape species and functional composition of forests. Wind has traditionally been considered the dominant dispersal mechanism in Ameri-Caribbean dry forests, yet growing evidence suggests that other dispersal mechanisms also play significant roles in this ecosystem, responding differently to biotic and abiotic conditions. Still, how dispersal syndrome composition influences plant communities, the ecological drivers underlying these patterns, and the effects of climate change on dispersal syndrome dominance remain poorly understood. …

Sex In Plants: Birth, Death, And Trying To Survive In Changing Climates, Elena M. Meyer

Theses and Dissertations

Plant mating systems are key determinants of fitness. Angiosperms exhibit a wide variety of reproductive strategies, including self-fertilization (or selfing), outcrossing, and mixed mating. It has been estimated that up to 43% of plant species are capable of selfing, and selfing has been hypothesized to provide reproductive assurance where opportunities for mating may be limited, such as in marginal environments. However, questions regarding the overall distribution of selfing rates across angiosperms, the maintenance of mixed mating in the face of inbreeding depression, and the impact of self-fertilization on diversification rates remain incompletely resolved. Here, we explore the dynamics of self-fertilization …

Real-Life Health Applications Of Wireless Sensing Using Edge Devices, Md Touhiduzzaman

Theses and Dissertations

Wireless sensing has emerged as a transformative paradigm that leverages ubiquitous radio-frequency signals for environmental perception and human activity recognition beyond their primary role in data communication. Unlike wearable sensors and camera-based systems, wireless sensing offers a non-intrusive, privacy-preserving, and cost-effective alternative that operates seamlessly under low-lighting conditions, through walls, and in non-line-of-sight (NLoS) scenarios. The growing availability of edge computing devices further enables real-time on-device data processing, making wireless sensing solutions highly suitable for in-home health monitoring and smart living applications. This dissertation investigates real-life health applications of wireless sensing through four completed systems, each addressing a distinct challenge …

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

Between Stigma And Strength: How Ghanaian Mothers Navigate Societal Judgement And Build Resilience While Raising Children With Disabilities., Vera Bonku Turkson

Theses and Dissertations

The study explores the lived experiences of mothers raising children with disabilities in Ghana, West Africa. The purpose of the study is to understand mothers’ everyday caregiving realities, their experiences with social stigma, and the ways they build resilience. A semi-structured interview was conducted where a total of eleven Ghanaian mothers/caregivers were interviewed through phone calls, WhatsApp calls, and Zoom. The data were then analyzed using Braun and Clarke’s (2006) thematic analysis guide, which resulted in the development of five themes. The findings reveal that mothers’ experiences are shaped by continuous caregiving demands, financial strain, and deeply embedded cultural beliefs …

Framing Belonging And Exclusion: A Dialogic Narrative Analysis Of English- And Spanish-Language Immigration Coverage During The Trump 2024 Presidential Election, Evangeline T. Cruz

Theses and Dissertations

I investigated how English- and Spanish-language news outlets narratively constructed Latinx immigrants during the Trump 2024 presidential campaign, a period marked by heightened anti-immigrant rhetoric and political volatility. While past scholarships examined immigration framing through tone, sentiment, or frequency analysis, limited attention has been given to the deeper narrative structures that shape public meaning-making. This study addresses this gap by applying Dialogic Narrative Analysis (DNA) and Critical Thematic Analysis (CTA) to a bilingual dataset of 120 newspaper articles from The New York Times, Los Angeles Times, El Diario, and La Opinión published between November 2024 and February 2025.

Findings reveal …

Building A Cell Specific System For In Vivo Rna Imaging Of The Endogenous Actin Gene In C. Elegans, Jasmine A. Huerta Canete

Theses and Dissertations

Messenger RNA (mRNA) plays a crucial role in protein synthesis and cellular processes, important for the development of cells such as neurons. When dysregulation occurs, it can lead to outcomes such as aberrant translation, causing neurodegenerative conditions to arise. Unfortunately, the localization of mRNA in an in vivo cell specific manner is still not understood. To address this, we decided to develop a cell-specific system to image RNA in vivo, within the organism known as C. elegans with a focus on the actin gene. The Actin gene encodes for an important cytoskeleton protein expressed ubiquitously, vital for the cell …

Nivel De Conocimiento Del Docente En Enfermería Sobre La Gamificación Y Su Actitud Hacia La Inclusión Como Estrategia Didáctica En Una Institución De Educación Superior En Puerto Rico, Elsa Geigel Landrau

Theses and Dissertations

La gamificación es una técnica de innovación que integra elementos de juegos para transformar la enseñanza en una experiencia activa en la modalidad presencial y virtual. Por ello esta disertación aplicada fue diseñada con el propósito de determinar el nivel de conocimiento del docente en enfermería sobre la gamificación y su actitud hacia la inclusión como estrategia didáctica en una institución de educación superior en Puerto Rico. Las bases teóricas que sustento este estudio fueron la Teoría Constructivista de Piaget (1980), la Teoría Social Cognoscitiva de Bandura (1977) y la Teoría de Autodeterminación de Ryan y Deci (2017); bajo este …

Percepción Del Docente Sobre El Uso Ético De La Inteligencia Artificial Generativa En Una Escuela Primaria De Nivel Básico En Puerto Rico, Leonardo Ramos Badillo

Theses and Dissertations

Esta investigación tuvo como propósito explorar la percepción de los docentes sobre el uso ético de la Inteligencia Artificial Generativa (IAG) en una escuela de segunda unidad en Bayamón, Puerto Rico, y su impacto en la integridad académica de los estudiantes. El estudio se fundamentó en dos marcos teóricos: la Teoría de la Elección Racional de Cornish y Clarke (1986), que permitió analizar cómo los educadores ponderan los beneficios y desafíos del uso de la IAG en el aula y, el Modelo de Aceptación Tecnológica de Davis (1989), que examina la actitud de los maestros hacia la integración de nuevas …

Play-Based Learning In Private International Preschools In Cairo: Teachers' Perspectives, Kesha L. Stovall

Theses and Dissertations

This thesis explores how play-based learning is practiced and contextualized in private, international preschools in Cairo, Egypt through the perspective of teachers. It calls upon both historical and contemporary theories of play and play pedagogies ranging from the times of Plato and Al-Farabi to the 21st century with Montessori and Dewey. Using a contemporary theory of play presented by Stuart Lester and Wendy Russell as a guiding framework, it examines how play and play-based learning are implemented, shaped and even challenged in a Cairene context. These contexts include sociocultural factors such as parents’ expectations and aspirations, institutional barriers, teacher development …

Effect Of Employees’ Breakfast Choices On Energy Levels In The Hispanic Population Working In Healthcare In South Florida, Jennifer Rivas

Theses and Dissertations

This applied dissertation was designed to examine the effect of employees’ breakfast choices on perceived energy levels among Hispanic healthcare workers in South Florida. As breakfast consumption has been widely associated with cognitive function, productivity, and metabolic stability, this research focused on understanding how specific breakfast patterns influence daily energy in a population that plays a critical role in regional healthcare delivery.

A qualitative survey was developed by the researcher and was used to collect data from Hispanic employees working in a variety of healthcare settings. Participants completed a structured survey assessing breakfast habits, nutritional quality, frequency of consumption, and …

Implementación De Estrategias En La Enseñanza De Los Números Reales A Estudiantes Con Formación Deficiente En Matemática, En Un Instituto Técnico Superior Comunitario De La República Dominicana, Antonio Manuel Rojas Taveras

Theses and Dissertations

Este estudio abordó la problemática del bajo rendimiento en la enseñanza y aprendizaje del conjunto de los números reales en estudiantes de un instituto técnico superior de la República Dominicana que presentaron una formación deficiente en matemáticas. Se observó que los métodos de enseñanza tradicionales, basados en la memorización y la repetición, no son efectivos para abordar las necesidades de estos estudiantes, lo que genera desmotivación y un serio obstáculo para la finalización de sus carreras. Además, factores como el contexto sociocultural, la falta de recursos didácticos, la escasa capacitación docente y los desafíos estructurales del sistema educativo dominicano contribuyeron …

Revisión Sistemática Sobre La Actitud Del Docente De Educación Preescolar Frente A La Incorporación De Niños Especiales Dentro Del Programa Regular Y Sus Efectos En El Aprendizaje De Estudiantes Regulares De Usa, Período 2015 Al 2024, Fressia Mary Medina Greenbaum

Theses and Dissertations

El propósito de esta investigación fue evidenciar hallazgos sobre la actitud del docente de educación preescolar frente a la incorporación de niños especiales dentro del programa regular de educación preescolar y sus efectos en el aprendizaje de estudiantes regulares en preescolares de Estados Unidos de América. La posición que adopte el docente es de suma importancia para el logro de la incorporación de estudiantes especiales desde temprana edad, conocer cuáles son los obstáculos que enfrenta el docente y aclarar cuales son los beneficios tanto para estudiantes especiales como para estudiantes regulares.

La presente investigación utilizó la revisión sistemática como metodología, …

Using Sports Performance Assessment Technologies To Help Narrow Achievement Gaps Of Black Male Adolescent With Other Racial Groups, Patavious R. Sorrell

Theses and Dissertations

This exploratory qualitative collective case study explored how sports performance assessment technologies (SPATs) may support the development of self‑regulatory and motivational processes associated with self‑efficacy among Black male adolescent student‑athletes. Guided by Social Cognitive Theory and the Technology Acceptance Model, the study examined the perceptions of eight coach‑teachers in the Southeastern United States who integrated video analysis, data analytics, goal‑setting and tracking applications, wearable devices and gaming platforms, and reflective communication tools into their coaching practices.

Data were analyzed thematically, revealing three major themes: self‑regulation, self‑mastery assessment, and academic transfer. Findings indicated that SPATs were most effective when used as …

Cultural Heritage Curriculum And Student Identity Development: A Mixed-Methods Study, Alexus Corley

Theses and Dissertations

This applied dissertation was designed to examine the influence of a cultural heritage curriculum on first-grade students’ cultural knowledge, awareness, and understandings of culture. Specifically, the study investigated the extent to which participation in a 4-week cultural heritage curriculum influenced students’ knowledge of cultural history and contemporary contributors, their understandings and perspectives about culture, and the convergence of quantitative and qualitative findings.

Using a qualitative-dominant mixed-methods research design, the study was conducted with 19 first-grade students enrolled in a Title I elementary school in Central Florida. Quantitative data were collected using the researcher-developed cultural knowledge preintervention and postintervention assessment and …

“America Is For Americans Only”: Journalistic Professionalism, Populism, And Latino Ethnic Media In The 2024 U.S. Presidential Election, Maria Villarroel

Theses and Dissertations

This dissertation examines how journalistic professionalism shaped news coverage of Latino-related issues during the 2024 U.S. presidential election across mainstream and Latino ethnic media outlets. In a polarized political environment, immigration and the “Latino vote” were not only central campaign issues but also sites of radicalized rhetoric that frequently targeted Latino communities and journalists. In this context, journalists were tasked with reporting on highly contentious, hostile narratives while adhering to professional norms. This study argues that these norms influenced how journalists selected, framed, and contextualized political rhetoric, and how media coverage further elevated immigration and Latino communities as key electoral …

Flowers Of Petra: The Identification Of Floral Motifs On Nabataean Painted Fine Wares, Jacob Samuel Blood

Theses and Dissertations

The Nabataeans are notable for their eggshell-thin fine ware pottery on which they often painted plant motifs. Since the discovery of these painted fine wares, several archaeologists have attempted to identify some of the plants depicted on the vessels. However, these attempts have often been incidental and not explicitly systematic. The purpose of this study is to apply the principles of plant taxonomy to identify eleven flower motifs that are depicted on Nabataean fine wares and to then determine what significance these flowers held for the Nabataeans. By using the principles of plant taxonomy, this thesis was able to confidently …

Investigating The Regulatory Impact Of Non-Coding Rnas On Meis1, Salma Fahim

Theses and Dissertations

Myeloid ecotropic virus insertion site 1 (MEIS1) is a transcription factor involved in a myriad of functions such as hematopoiesis, cardiac regeneration, cell cycle progression, cell proliferation, and limb and organ development. Precise control of MEIS1 expression and function is essential for maintaining cellular homeostasis and preventing pathological conditions including cancer. Emerging evidence suggests that non-coding RNAs (ncRNAs) play a significant role in fine-tuning MEIS1 activity. Unmasking these regulatory mechanisms could provide potential therapeutic strategies for conditions where MEIS1 is aberrantly expressed. The present dissertation presents a comprehensive overview of current knowledge on MEIS1, synthesizing findings from the literature to …

The Role Of Dust Inputs And Sediment Phosphorus Diffusion Into Utah Lake, Utah, United States Of America, Kristen E. Smith

Theses and Dissertations

Human activities have led to excessive nutrient enrichment which is greater than lake systems can naturally assimilate. This process is known as eutrophication and it is driving significant algae growth resulting in the more common release of harmful toxins. Utah Lake, located in Utah County, UT is one such water body that even after major reductions in anthropogenic phosphorus influent, continues to experience frequent, harmful algal blooms. The extent to which natural processes, like atmospheric dust deposition and sediment recycling, contribute to the lake's phosphorus budget is still poorly understood.

To address this gap of knowledge, this study quantified phosphorus …

Using Rhizobia Seed Coatings And Soil Amendments To Combat Herbicide Toxicity For Native Legume Establishment, Ryan Matthew Glover

Theses and Dissertations

Dryland ecosystems face widespread degradation from historical mismanagement, climate change, and invasive species proliferation. Although herbicides effectively control invasive annual weeds, they often suppress the establishment of desirable perennial species, limiting restoration success. Legumes enhanced with rhizobia inoculants offer a promising approach to overcome these challenges by facilitating nitrogen fixation, improving soil microbial communities, and potentially mitigating herbicide stress. We conducted paired greenhouse and field experiments to evaluate whether rhizobia seed coatings improve the establishment of three legume species Astragalus cicer (Cicer Milkvetch), Onobrychis viciifolia (Sainfoin), and Medicago sativa (Alfalfa), in soils treated with imazapic and glyphosate. In the greenhouse, …