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Madness Is The Emergency Exit: A Survey Of Super Trauma, Justine Nicole Wilson

Theses and Dissertations

This dissertation is a survey of trauma as depicted within the Batman mythos. The first chapter, “The Serious House,” explores the history of New York State’s insane asylum system and its relationship to the creation of the fictional Arkham Asylum. The opening chapter also features a close reading of Grant Morrison’s Arkham Asylum: A Serious House on Serious Earth (2005) and employs Michel Foucault’s Discipline and Punish (1995) and Madness and Civilization (1988) as critical frameworks. The dissertation's second chapter, “There is no Sanity Clause,” is a detailed examination of the Joker’s character. The Joker is an advocate for the …

A Methodology Of Paradoxes: Investigating Authenticity In The Representation Of Queerness On The Contemporary Stage, Kendall C. Walker

Theses and Dissertations

In my experience as a queer theatre practitioner, performer, and student, I have always had questions of ownership and authenticity when it comes to LGBTQIA+ narratives on the contemporary theatre stage. The question of: “Who is allowed to tell what story?” and the many complex ideas that this leads to, is what has inspired this thesis and my own pedagogy of intersectionality and inclusivity.

The purpose of this thesis is to investigate the relationship between authenticity and queerness on the contemporary stage in order to develop a methodology for how all theatre practitioners—no matter their identity—can effectively tell queer-identifying stories …

Bet Inhibition As A Strategy For Enhancing The Response To Estrogen Antagonism/Cdk4-6 Inhibition In Er Positive Breast Cancer, Ahmed M. Elshazly

Theses and Dissertations

Breast cancer is the most commonly occurring malignancy in females, accounting for the second most common cause of cancer-related deaths. ER+ breast cancer constitutes approximately 70% of all breast cancer cases. The standard care of therapy comprises endocrine antagonists together with adjuvant therapy; however, the recovery from the therapy-suppressive state is associated with further drug resistance together with increasing tumor aggressiveness and with possible metastasis. Autophagy induction has been shown to be associated with various therapeutic modalities, with different functions, including cytotoxic, cytoprotective, cytostatic as well as non-protective forms. The triggering of autophagy may be responsible for resistance development and …

An Introduction To Theatrical Scent Design As Compared To Traditional Design Areas With A Consideration For The Scientifically Notated Physical And Emotional Effects On The Human Body As It Potentially Relates To Future Creative Endeavors: A Framework, Katherine R. Holland

Theses and Dissertations

Traditional areas of theatrical design are established to the point of having a solid foundation for current and future designers to rely on as they strive to innovate. The same cannot be said for scent. I believe that art, like science, is a sector where the imagination is used to push the boundaries of what we currently know and can do. Artists are therefore entrusted with the responsibility to continue testing those boundaries, and that is what my topic lays the foundation for when it comes to scent. With my topic, I plan to look at the practical and ethical …

Effects Of Hiv-1 Tat And Opiates On Gene Regulation Of Oligodendrocyte Lineage Cells: Identification Of Myrf As A Novel Target, Kelly M. Flounlacker

Theses and Dissertations

HIV-associated neurocognitive disorders remain pervasive even with increased efficacy/use of antiretroviral therapies. Opioid use/abuse among HIV+ individuals is documented to exacerbate deficits. White matter (WM) alterations (myelin pallor, volume/structural) detected by diffusion tensor imaging, are common observations in HIV+ individuals. Using transgenic mice expressing HIV-1 Tat, we examined effects of 2-6 weeks of Tat/morphine exposure on WM using genomic/biochemical methods. RNA sequencing of striatal tissue after 2-weeks revealed robust changes in mRNAs associated with oligodendrocyte populations/myelin integrity, including Transferrin, Ndrg1, and myelin regulatory factor (Myrf/Mrf), an oligodendrocyte-specific transcription factor involved in differentiation/maturation. Immunoblots conducted after 6-weeks exposure in …

Quantifying Insect Emergence In Tidal Freshwaters And The Importance Of Aquatic Prey In Wetland-Dependent Songbird Diet, Samantha L. Rogers

Theses and Dissertations

Insectivorous birds and their arthropod prey are experiencing widespread population declines, driven largely by anthropogenic disturbance and climate change. For wetland-dependent insectivores that consume a mixture of terrestrial and aquatic insects, understanding the availability, consumption, and nutritional qualities of aquatic diet subsidies is important for conservation. I use prothonotary warblers (Protonotaria citrea) as a model species throughout this work, because their breeding season aligns with aquatic insect emergence and they include aquatic insects when provisioning nestlings. In the first chapter, I estimate aquatic insect emergence from tidal freshwaters, which are understudied compared to nontidal systems. Using continuous field …

Modulation Of Opioid-Induced Respiratory Depression By Stimulants And Their Associated Monoaminergic Receptor Mechanisms In Mice Using Whole Body Plethysmography, Harrison J. Elder

Theses and Dissertations

Opioid overdose and associated deaths involving opioid-induced respiratory depression (OIRD) began to accelerate beginning in 2015 with the emergence of illicitly manufactured fentanyl and its analogs and currently represents one of the most significant public health challenges in the United States. The increases in overdose deaths have occurred despite the increased availability of the opioid overdose reversal agent, naloxone, to first responders and the public. This new phase of the opioid epidemic has been paralleled by substantial growth in the co-use of opioids with stimulants, particularly methamphetamine. The objective of this dissertation is to ascertain whether fentanyl is particularly resistant …

A Six-Month Comparison Of Orthodontic Pain Associated With Fixed Edgewise Appliances And Clear Aligners, Victor Chan

Theses and Dissertations

Title: A Six-Month Comparison of Orthodontic Pain Associated with Clear Aligners and Fixed Edgewise Appliances

Objective: To document and compare pain perception, intensity, and analgesic use over a sixmonth period between patients treated with fixed appliances (FA) and clear aligners (CA).

Methods: A prospective, parallel, two-arm, multi-center, longitudinal cohort study was conducted with 87 adults treated with CA (n=59) or FA (n=28). Subjects were selected according to inclusion and exclusion criteria. A seven-item, digital survey was sent at three timepoints (preappointment, 2-days post-appointment, and 7-days post-appointment) at each adjustment over a six-month period. The variables measured included pain experience, pain …

Biting Range, Effie Bowen

Theses and Dissertations

Biting Range is an essayic text about dogs, process, order, and memory. Structured as a conceptual material list, the writing addresses experiential textures and tensions gleaned from observation. Writing within and against the margins, I address the performativity of the page as its own form to be agitated.

How Stromal Interactions Play A Role In The Quest For Human Papillomavirus Specific Cancer Therapeutics, Alexis-Leigh A. Fakunmoju

Theses and Dissertations

High-risk human papillomaviruses (HPV), like HPV16 and HPV18, are associated with malignant cancer growth within the oropharynx and cervix. Globally, HPV-induced cancers, including oropharyngeal and cervical cancers, contribute 5% to the overwhelming burden of all cancers. HPV is highly transmissible by sexual contact via micro abrasions to the mucosa. Once exposure occurs, the virus begins replication and creates an intimate relationship with the host’s cellular proteins. While most HPV is cleared quickly by our immune system, persistent infections, or infections in immune compromised individuals, are susceptible to transformation and tumor progression. Early detection measures like PAP smears and preventable measures …

Radiation Shielding Effectiveness Of Hafnium Diboride (Hfb2) Reinforced Epoxy Composites For Enhanced Radiation Protection And Safety, Furkan Erdogan

Theses and Dissertations

This thesis investigates the radiation shielding effectiveness of hafnium diboride (HfB2) reinforced epoxy composites, with the aim of enhancing radiation protection and safety in various applications. The study focuses on the development and characterization of HfB2-epoxy composites with varying weight percentages of HfB2 nanoparticles, as well as on the evaluation of their shielding effectiveness against gamma rays and thermal neutrons. The radiation shielding performance of the composites is assessed using gamma-ray spectroscopy and neutron counting, and the neutron attenuation efficacy is compared with that of 5% borated high-dense polyethylene. The results indicate that the HfB2-epoxy composites exhibit promising radiation shielding …

Totem Impulse, Tendai T. Mupita

Theses and Dissertations

In this reading, I explore the performative and complexities of indigenous mythologies, cosmologies, and epistemologies, through totems, folklore, architecture, and games. This paper extracts references from indigenous philosophies in thinking about form and image. These forms and images are my sculptures, my installations, and my lines.

Behind The Gate: Syrian Women In Soap Operas - Perception Vs. Reality, Tasnim J. Rahimah

Theses and Dissertations

Syria has witnessed what is known as al-fawra al-drameya, an eruption of drama since 2000. Every year, especially during Ramadan, dozens of Syrian soap operas are aired across the Arab world and beyond, depicting Syrians’ historical struggles as they fought for liberation from the French mandate at the beginning of the 20th century. Although women of those days were a vital part of that liberation movement and had prominent societal roles, these historical fiction soap operas chose to portray only the demure and dismissive female figures and not mention the women who were independent, courageous, and active members of the …

Exploring Polyamorous Relationship Experiences Of Lesbian, Gay, Bisexual, And Pansexual Individuals, Jiale Man

Theses and Dissertations

Polyamory is a type of relationship under the consensual non-monogamy relationship umbrella that assumes the possibility, validity, and worthwhileness of maintaining romantic, sexual, and intimate relationships with multiple people simultaneously. In Western society, the prevalence and domination of mononormativity have led to the marginalization of relationships alternative to monogamy (i.e., polyamory). As a result, individuals in polyamorous relationships continue to experience bias, stigma, and discrimination at varying levels. With a rise in public interest in CNM in the past two decades, scientists and researchers have slowly started to examine various topics related to CNM, including its prevalence, public attitudes toward …

The Effect Of Strain And Drug Combinations On Ketamine's Locomotor Activating Effects In Rats, Caroline K. Flagler

Theses and Dissertations

Rationale: Initially developed as an anesthetic, ketamine is now used to treat a variety of disorders, including treatment resistant depression (TRD). While ketamine appears to be a breakthrough therapy for TRD, it has many use-limiting side effects, including abuse liability, psychotomimetic effects, and sedation. Utilizing ketamine in combination with other medications, such as the monoaminergic antidepressant desipramine (DSP), opioid antagonist naltrexone (NTX), and the NMDA receptor partial agonist D-cycloserine (DCS) may reduce side-effects resulting from ketamine therapy.

Objectives: The goal of this project was to study ketamine’s adverse effects using locomotor activation in an open field as a behavioral correlate …

Advanced Modeling And Innovative Transcranial Magnetic Stimulation Coil Designs For The Treatment Of Neurological Disorders, Mohannad Tashli

Theses and Dissertations

Transcranial magnetic stimulation (TMS) is a safe, effective and non-invasive treatment for several mental and psychiatric disorders. TMS is an FDA approved treatment and is commonly applied to patients who do not respond to medications for the treatment of clinical depression, smoking cessation, obsessive-compulsive disorder and migraine. Recently, there has been an increase in the development of electromagnetic neuromodulation techniques targeted at enhancing the effectiveness of TMS devices for the treatment of mental diseases. In TMS stimulation, focality is an important factor which determines the specificity of the pulses induced in different brain tissues. The electromagnetic pulses must be confined …

Evaluating The Influence Of Concurrently Available Non-Drug Reinforcers On Drug Reinforcement Using Sophisticated Preclinical Models Of Substance Use Disorder, Madison M. Marcus

Theses and Dissertations

The maladaptive allocation of behavior towards cocaine and away from other concurrently available non-drug reinforcers (e.g., family, health, work, etc.) is a key characteristic of cocaine use disorder (CUD) that is embedded into multiple diagnostic criteria for CUD. Accordingly, basic research conducted in a drug-vs-food “choice” context has improved our fundamental knowledge of the behavioral and neurobiological mechanisms of drug reinforcement. However, to date, these preclinical studies have only been conducted with food as the alternative reinforcer. The extent to which other non-drug reinforcers compete with cocaine-taking behavior is unknown. The studies in this dissertation establish two sophisticated discrete-trial cocaine-vs-alternative …

Characterization And Decoding Of Speech Activity From Intracranial Signals, Pedram Zanganeh Soroush

Theses and Dissertations

Speech is the first and foremost means of human communication. Millions of people worldwide suffer from severe speech disorders due to neurological diseases such as amyotrophic lateral sclerosis (ALS), brain stem stroke, and severe paralysis. A speech neuroprosthesis that decodes speech directly from neural signals could dramatically improve life for these individuals. Recent studies have demonstrated that it is possible to decode and synthesize various aspects of acoustic speech directly from intracranial measurements of electrophysiological brain activity. For those who have completely lost the ability to speak, the objective is to synthesize acoustic speech directly from brain activity during imagined …

Modulation Of Epigenetic Regulatory Pathways As A Therapeutic Strategy In Breast Cancer, Ryan M. Finnegan

Theses and Dissertations

Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are the current standard of care for estrogen receptor-positive (ER+) Her-2 negative metastatic breast cancer. In triple negative breast cancer, cytotoxic drugs and ionizing radiation are often used as standard of care. Although these therapies prolong progression-free survival, the growth-arrested state of residual tumor cells is clearly transient. Tumor cells that escape what might be considered a dormant state and regain proliferative capacity often acquire resistance to further therapies. Epigenetic regulation can modulate the effects of cancer therapeutics. Our studies are based upon the observation that …

Novel Strategies In Head And Neck Tumor Therapy; Contribution Of Senescence In Therapy Response, And Resistance Development After Cisplatin Treatment, Fereshteh Ahmadinejad

Theses and Dissertations

Therapeutic outcomes achieved in head and neck squamous cell carcinoma (HNSCC) patients by concurrent cisplatin-based chemoradiotherapy initially reflect both tumor regression and tumor stasis. However, local, and distant metastasis and disease relapse as well as cisplatin-induced resistance are common in HNSCC patients. In the current work, we demonstrate that cisplatin treatment induces senescence in both p53 wild- type HN30 and p53 mutant HN12 head and neck cancer models. We also show that tumor cells can escape from senescence both in vitro and in vivo. We further established a cisplatin-resistant cell line from HN30 parental cell line that underwent brief senescence …

Laying Out A Space: Spectral Geographies, Fictions Of The Soul, Erin D. Yerby

Theses and Dissertations

Laying out a Space: Spectral Geographies, Fictions of the Soul, arises out of my artistic practice, and thoughts behind my current project and MFA exhibition, Spectral Geographies.

Linking the problem of the world ‘out there’ or external space, to inner experience through painting as both medium and practice, my work expresses what I call inner geographies, spaces where intimate immensities, folding inside and outside, find expression. I think of my paintings as beginning with this gesture of laying out a between-space where the intimacies of waking dreams and visions are opened by, and grow into, actual places, …

I'M Not Sure It Was A Hoopoe Or A Decanter, Ali Kaeini

Theses and Dissertations

“I’m not sure it was a Hoopoe or a Decanter” explores the experience of cultural displacement through the lens of an Iranian artist and immigrant. Drawing on ancient Iranian stories, Persian poetry, and cultural artifacts, my paintings and drawings reflect the uncertainty of the contemporary political and religious conditions in Iran, as well as the challenges faced by individuals forced to flee their homeland due to war, political instability, and social conditions. My work weaves references to ancient Iranian objects, Persian miniatures' structural forms and patterns, and Islamic architecture, using traditional and contemporary materials to create large, unconventional paintings. Through …

Nohwi Nadeesh Diyih: Honoring Indigenous Health Through Research, Evaluation, And Policy, Danya S. Carroll

Theses and Dissertations

American Indian and Alaska Native (AI/AN) communities in the United States (US) represent culturally rich food landscapes, traditions, and languages. Food access remains a public health issue in AI/AN communities that is influenced by a myriad of factors. Indigenous food cultures and Indigenous languages are also underappreciated factors in the health of AI/AN communities. This dissertation in practice is guided by both the Social Ecological Model (SEM) and Indigenous Evaluation Framework (IEF) Model with the intent of highlighting multilevel culturally aligned approaches to promoting AI/AN health through food access and Indigenous languages. Specifically, this dissertation in practice sought to platform …

Stage-Structured Predator-Prey Interactions In A Warming World: A Case Study In Riverine Rock Pools, Andrew T. Davidson

Theses and Dissertations

Warming can impact predator-prey interactions through a variety of mechanisms. For example, warming can both alter the rate at which predators consume prey and the rate prey develop through vulnerable life stages. Thus, the overall effect of warming on consumer-resource interactions will depend upon the strength and asymmetry of warming effects on predator and prey performance. Here, we describe the consequences of these asymmetrical responses to temperature by first developing a simple stage-structured modeling framework, then applying that framework to predation of American rock pool mosquito larvae, Aedes atropalpus, by several common predators in riverine rock pools. We then …

Interactions Between Hiv And Opioids On Antiretroviral Accumulation, The Blood Brain Barrier, And The Inflammatory Response In The Brain., Kara Rademeyer

Theses and Dissertations

The complex mechanisms related to HIV infection, neurodegeneration, and chronic neuroinflammation collectively describe neuroHIV (Hauser et al. 2007; Chang et al. 2014; Smith et al. 2014). Specifically, opioid abuse, poor penetration of antiretroviral (ARV) drugs, chronic inflammation and neuronal injury/degeneration are all implicated in neuroHIV (Fantuzzi et al. 2003; Letendre et al. 2004; Verani et al. 2005; Duncan and Sattentau 2011; Hong and Banks 2015; Simoes and Justino 2015; Olivier et al. 2018; Murphy et al. 2019; Osborne et al. 2020). For the first time, we demonstrate that morphine, fentanyl, and methadone in vivo alter the brain accumulation of ARVs, …

Climate, Physiology, And Distributions: The Role Of Thermal Physiology In Biological Invasions, Sean D. Powers

Theses and Dissertations

Climate is a primary factor influencing species range dynamics, particularly for ectotherms whose body temperature is closely tied to the surrounding conditions. While range shifts of ectotherms are attributed to climate warming, the mechanism driving these shifts are not well understood. Studies in macrophysiology demonstrate that the interaction of climate with thermal physiology plays a key role in determining large-scale spatial and temporal patterns for many temperature-sensitive physiological traits. This work has revealed a clear relationship between thermal tolerance breadth and range size. However, more recent analyses of this relationship demonstrate that thermal tolerance breadth only provides a partial explanation …

Diversity, Phylogenetics And Life Cycles Of Diplostomoidean (Digenea: Diplostomoidea) Of The Upper Midwest, Jakson Martens

Theses and Dissertations

The superfamily Diplostomoidea Poirier, 1886 consists of a diverse, globally distributed group of parasitic flatworms parasitic as adults in reptiles, birds, mammals, and very rarely, fish. The superfamily Diplostomoidea has a tumultuous history full of genus synonymizations and resurrections. Currently, the superfamily consists of 39 genera parasitizing primarily piscivorous animals as adults to include birds, reptiles, and mammals. This group of parasitic worms remains a highly active area of research and has recently undergone several major systematic changes including the abandonment of a subfamily-based system. Additionally, the influx of data entries in GenBank has lead to confusing nomenclature and misidentifications …

Perinatal Mental Health For Indigenous Women And Birthing People, Amy Lynn Stiffarm

Theses and Dissertations

Before for the impacts of colonization, Indigenous women and birthing people were deeply cared for by their communities during pregnancy, birth, and the postpartum period.There is a serious lack of literature on perinatal mental health (PMH) for Indigenous Peoples in the US. Based on what limited data does exist, high rates of PMH complications are consistently reported for Indigenous birthing people. Exploring the unique circumstances experienced by Indigenous birthing people is crucial to addressing the PMH disparity gap. A concept map illustrating the systematic, community, and individual levels of PMH complications for Indigenous Peoples was used to organize and guide …

Hmong Parent Engagement: The Need To Provide Basic Needs Services In Hmong Charter Schools To Increase Parent Engagement, Kevin Xiong

Theses and Dissertations

The Hmong diaspora and settlement in the United States have a direct impact on how Hmong parents engage in their children’s academic journey. With the viewpoint of traditional Westernized parent engagement, Hmong parents may be perceived as engaging too little. However, in order for Hmong parents to be involved in their children’s educational journey as part of this Westernized concept, it is imperative that the families’ basic needs are met. Otherwise, they will primarily focus on meeting their fundamental basic needs rather than being engaged in their children’s academic progress. This research explored two Hmong charter schools in the Twin …

Changes In Crop Diversity And Associated Drivers In The Red River Of The North Valley, Zinat Ara

Theses and Dissertations

Background: Crop diversity is a part of the overall biodiversity of the world and includes the diversity of crops produced to feed humankind and those associated with domesticated animal grazing or feeding. A decline in diversity can reduce productivity of the farmlands by degrading soil health and introduction of plant diseases. So, it is crucial to study crop diversity and find the causes behind it to impede catastrophic consequences.Objectives: The purpose of this study was to explore changes in crop diversity and the factors affecting the changes in diversity by county and survey townships in the Red River of the …