Digital Commons Network^™

Cancer Treatment By Targeting Hdac4 Translocation Induced By Microsecond Pulsed Electric Field Exposure: Mechanistic Insights Through Kinases And Phosphatases, Zahra Safaei

Theses and Dissertations

Epigenetic modifications, arising from sub-cellular shifts in histone deacetylase (HDAC) activity and localization, present promising strategies for diverse cancer treatments. HDACs, enzymes responsible for post-translational histone modifications, induce these epigenetic changes by removing acetyl groups from ε-N-acetyl-lysine residues on histones, thereby suppressing gene transcription. Within the HDAC group, class IIa HDACs are notable for their responsiveness to extracellular signals, bridging the gap between external stimuli, plasma membrane, and genome through nuclear-cytoplasmic translocation. This localization offers two significant mechanisms for cancer treatment: nuclear accumulation of HDACs represses oncogenic transcription factors, such as myocyte-specific enhancer factor 2C (MEF2C), triggering various cell death …

Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu

Theses and Dissertations

Severe back injuries and chronic pain necessitate surgical replacement of damaged intervertebral disc (IVD) cartilage in advanced disease stages. Bovine IVD tissue has been exposed to an upper threshold pulsed electric field (PEF) dose, causing cell death without thermal damage to the tissue. Subsequent PEF exposures at lower magnitudes have accelerated the removal of immunogenic biomolecules though electrokinetic extraction using optimized aqueous solutions. This approach yields a natural scaffold, ready for biocompatibility and mechanical strength assessment. The effects of microsecond pulsed electric fields (µsPEF) on primary bovine AF fibroblast-like cells have been characterized in vitro. PEFs of 10 and 100 …

Integrated Computer-Aided Design, Experimentation, And Optimization Approach For Perovskites And Petroleum Packaging Processes, Swapana Subbarao Jerpoth

Theses and Dissertations

According to the World Economic Forum report, the U.S. currently has an energy efficiency of just 30%, thus illustrating the potential scope and need for efficiency enhancement and waste minimization. In the U.S. energy sector, petroleum and solar energy are the two key pillars that have the potential to create research opportunities for transition to a cleaner, greener, and sustainable future. In this research endeavor, the focus is on two pivotal areas: (i) Computer-aided perovskite solar cell synthesis; and (ii) Optimization of flow processes through multiproduct petroleum pipelines. In the area of perovskite synthesis, the emphasis is on the enhancement …

Repeat After Me, Bonnie Morano

Theses and Dissertations

Bonnie Morano’s devotional abstract oil paintings are an offering of conviction reconciled with joy. Balancing spiritual zeal with geometric space, she creates mirrored compositions filled with gravitas and play. The sacred and domestic join together in maximal harmony, examining alternative arrangements of transcendental experience.

Where The Under And The Over Meet And Disappear, Louisa Owen

Theses and Dissertations

Vignettes of light: light disappearing, light contrasting, light directing, light wandering, and light uncovering.

This Life Is A Constant Rehearsal, Alex Schmidt

Theses and Dissertations

Alex Schmidt’s conceptual practice explores the artist’s precarious condition as an affective freelance worker; a utopian parasite. Schmidt employs paintings as props, performance as muse, and writing on transactional care as a metaphor for this cobbled life.

Barley As A Human Companion Species - Exploring The Relationship Between Barley And North Atlantic Peoples: 4000 Bc – Ad 1200, Chloe Combs

Theses and Dissertations

Barley (Hordeum vulgare) is an ancient cereal crop originating in the Fertile Crescent approximately 12,000 years ago and is presently one of the most important cereal crops globally. Barley has a long and complex history. This thesis aims to explore one dimension of this history through the lens of human companion species using archaeobotanical data collected from the islands of the North Atlantic from the Neolithic (4,000 BC) to the Norse period (AD 1200).

The Black Arts And Black Power Movements In The Artwork Of John T. Riddle, Jr., Isabella Vitti

Theses and Dissertations

This thesis examines the under-studied work of the Black sculptor John T. Riddle, Jr. and how he was influenced by the politics of Los Angeles in the 1960s and 1970s. Police brutality, the Vietnam War, the Black Power Movement, and the Watts uprising had a major impact on Riddle’s work.

Crucifixion Can Happen To Anyone: Embodying Christ Through The Queer Artist, Xander Guyer

Theses and Dissertations

In the late 20th century, queer artists incorporated the Crucifixion into their artworks, embodying a crucified Christ in the process. This thesis seats these contemporary works within traditional Christian art history, a position long denied to these transgressively queer artists.

A Grid And A Shadow, Henry Glavin

Theses and Dissertations

Henry Glavin's acrylic paintings on panel of architectural interiors and facades use repetition, contrived light, unreliable shadows, photographic posture, and compressed detail to create uncanny spaces that generate an air of silence.

Through Their Eyes: Illuminating The Nature Of Animal Use In Conservation Research Through An Analysis Of Peer-Reviewed Literature In The Journal Conservation Biology, Sarah Hollmann

Theses and Dissertations

Non-human animals habitually have been treated as a resource in the service of humans and human-driven values. The field of conservation is not immune to this fact. But, because conservation is seemingly dedicated to the saving and protection of species and nature, until recently the field historically has been given a pass for the use and treatment of animals that are done “in the name of conservation”. This treatment is evident in common conservation practices such as capture, captivity, invasive sampling, aversive treatment, experimental manipulation, and intentional killing. A principal question we are asking is how individual animals are impacted …

Evaluating Differences In Expression Of Neuroticism In Individual Homed Cats And Feral Cat Colonies Across Varying Degrees Of Human Settlement, Sophie Ambrosino

Theses and Dissertations

Neuroticism is a dimension of personality that was first defined for human psychology as a collective measure of excessive tendencies towards stress, anxiety, fear, unwarranted aggression and/or instability. In a two-part study, this project aimed to identify neuroticism as an observable personality dimension in domesticated cats, and to investigate if the expression of neuroticism varies on an individual and population level in correlation with an increase in environmental stressors and scarcity based upon degree of urbanization of the site. One component of the study surveyed cat owners about personality traits and daily lifestyle of their cats to test the viability …

Francesco Clemente: In One's Self Lies The Whole World, Lorraine Robinson

Theses and Dissertations

Francesco Clemente’s body of work, especially between 1992 and 2014, theoretically draws from the Hindu concept of the avatāra, wherein the figures he portrays interminably exist in a state of flux and unraveling. Many of the figures discussed are inspired by Indian spirituality, mythology, and popular culture. Nonetheless, rather than comprehending them as literal interpretations, they exist through a prism of references.

The research conducted throughout this thesis combines analyses gathered from academic essays and books by notable Indian scholars, such as Jyotindra Jain and Partha Mitter. These two distinct voices coalesce to elucidate deep insight into Clemente’s aesthetic, personal, …

A Year As A Monk Parakeet, Eric Thompson

Theses and Dissertations

Monk parakeets are a species of parrot native to subtropical and temperate regions of Argentina, Brazil, Uruguay, Paraguay, and Bolivia that have been introduced to many parts of the world. Monk Parakeets have lived in Brooklyn, New York since the 1970s and many myths and legends surround how these birds came to live here. This thesis is a description of the behavior of monk parakeets in Brooklyn, New York’s Greenwood Cemetery based on observations I conducted twice a week from January through October of 2023. Because of the unusual nature of this population of parakeets as well as their unique …

Scattered Fragments: Art, Architecture, And Archives In Revolutionary Urban Cairo, Mounira M. Makar

Theses and Dissertations

This thesis analyzes how revolutions impact urban Cairo and its communities, specifically within artistic, architectural and archival practice while acknowledging the central role of public spaces in giving way to such revolutionary practices. Fundamentally, this paper highlights the foundational nature of such practices in developing urban communities.

May The Soil Be Everywhere: Portraying A Family's Love And Revolution Through Oral History, Performance, And Film From A Granddaughter's Perspective, Yehui Zhao

Theses and Dissertations

May the Soil Be Everywhere is a feature-length documentary film that tells an intimate four-generational family story about farming, survival, and regeneration. Set against a backdrop of war, famine, and rapid urbanization, May the Soil Be Everywhere delves into oral history, trauma, family heritage and generational love. It represents a community’s collective effort to preserve its identity.

Individual Concepts And Personal Identity Judgement, Molly M. Ye

Theses and Dissertations

Previous research into personal identity judgments has yielded conflicting outcomes. This paper introduces an alternative argument, proposing that the concept PERSON and HUMAN BEING provide different ways of thinking about the identity of people. Two experiments in this study provide evidence for this claim.

From Sins Of The Cities Of The Plain To Letters From Laura And Eveline: Boulton, Park, And Pornography’S Reaction To Transmisogyny, Daniel Falco

Theses and Dissertations

This thesis builds on the emerging work of scholars who view pornography as literature with sociocultural relevance and adds to trans scholarship through a dissection of gender construction and transmisogyny in a Victorian underground subversive culture. Centering the 1883 erotic novel Letters from Laura and Eveline, I examine how language and biology are unfixed to highlight fluidity within queer sex and gender, and how this helps the novel evade the taxonomical-obsessed era in which it was produced. I examine its roots in the real historical figures of Ernest “Stella” Boulton and Frederick “Fanny” Park, two crossdressers who were arrested a …

Say “Ah,” Not “Ahhh!” - Parent Intervention For The Reduction Of Dental Anxiety In A Child With Autism, Alexandra Luisa Vernice

Theses and Dissertations

The overall oral health status of children with autism is significantly poorer as compared to children without autism primarily due to dental anxiety. High levels of anxiety often contribute to behavioral distress. These difficulties, coupled with deficits in communication and coping skills, result in challenging behaviors for children with autism during routine dental cleanings. Currently, there is limited research on effective treatment packages and procedures for managing dental anxiety in children with autism, and no studies have trained parents as intervention agents to treat dental anxiety in this population. In this single-case study, a parent training intervention was delivered to …

Symbiosis Under Stress: Unraveling The Interplay Of Ocean Acidification And Rising Temperatures On Acropora Samoensis (Staghorn Coral), Jerald William Smolkin

Theses and Dissertations

This experiment explores the response of marine organisms to the combined challenges of ocean acidification and rising temperatures, with a focus on coral reef ecosystems. As global climate change threatens profound declines in coral reefs, understanding the multifaceted impacts of these stressors becomes crucial. The study observes cellular changes in A. samoensis tissues in four different groups, including control, Temp, pH, and Temp and pH. Results indicate significant breakdown of membrane compartmentalization and cell junctions, with notable degradation and calcium carbonate crystallization in pH-stressed samples. Additionally, chlorophyll extraction data support coral bleaching due to the expulsion of zooxanthellae. These findings …

An Exploration Of The Relationship Between Reading Habits And Reading Achievement In Elementary Schools, Donna M. Deodato

Theses and Dissertations

This study explored the multifaceted dynamics affecting the academic performance of high-achieving elementary students on end-of-year reading exams. It examines the influences of gender, age, genre preferences, the frequency of book borrowing, and language modality of instruction, all within the context of the elementary school library. Methodologically, the study employs a quantitative correlational approach. The data source comprises students' demographics, class assignments, end-of-year reading scores, and library patron records. Through the lens of Bronfenbrenner’s Ecological Systems Theory, this research aimed to enrich our understanding of various interconnected systems in students’ environments, such as family, school, and community, with each level …

Reevaluating Positive Freedom Through The Philosophy Of Amartya Sen With A Focus On Education As A Catalyst For Freedom, Emilie Mathilde Vesten Haakansson

Theses and Dissertations

Education has since ancient times been used as a societal tool to develop and cultivate society’s individuals into participating members. Education which is considered a fundamental human right also holds potential transformative power to enable and empower individuals to exercise their freedom to create a life that aligns with their own values, ideas and goals. However, how effective an educational system can be, ultimately depends on the accessibility and quality of the education as well as the overall system the educational institutions operate in. This thesis explores how education can function as a catalyst for furthering individuals’ freedom through a …

Secondary Ela Teachers’ Perceptions Of Classroom Dynamics In A Technology-Rich Learning Environment, Graham Otton

Theses and Dissertations

The purpose of this narrative study was to explore secondary ELA teachers’ perceptions of teaching and learning in a technology-rich educational environment. This study was conducted in a central high school district in New York state across four school buildings. Though the central high school district provides uniform guidance and material for the instructional programs in all high school buildings, the execution of instruction and teacher development happens daily in the buildings themselves. Though one district, each building serves distinct communities with pronounced school cultures stemming from varying student and faculty demographics, as well as building leadership. The researcher explored …

A Systematic Review And Meta-Analysis Of Psychosocial Interventions For Early Childhood Problems, Ages 0-5, Hara Stephanou

Theses and Dissertations

Early childhood consists of important developmental milestones, including the acquisition of daily living skills, including toileting, feeding, and sleep. While previous reviews have focused on interventions for some childhood problems, no single study has broadly assessed interventions across common presenting problems in children ages 0-5. This study systematically reviewed 41 studies on interventions for externalizing (23 studies), internalizing (3), sleep (11), feeding (3), and toileting (1) using meta-analytic methods where applicable. Overall, externalizing interventions were effective (TX1 Hedges' g = -.60; TX2 g = -.51) and largely homogeneous. Individual interventions reduced externalizing behaviors more than group or self-guided interventions (TX1 …

A Longitudinal Examination Of The Relations Between Racial Discrimination And Executive Function, Aldona Chorzepa

Theses and Dissertations

Discrimination has been linked to changes in executive function. This relationship may explain links between discrimination and adverse health and mental health outcomes, including depression, substance use, and health behavior. To date, the research examining this question has been limited, as the majority of studies reviewed employed experimental manipulations for discrimination exposure and tested acute same-day effects in the lab. Clarifying the extent to which exposure to discrimination impacts executive function over time in young adults is crucial to identifying opportunities for intervention. The current study evaluates the relations of both recent and lifetime exposure to racial discrimination to three …

Paresthesia Due To Peripheral Neuropathy: Anxiety And Wellbeing, Nikolas Cirillo

Theses and Dissertations

Purpose: Neuropathic pain has been linked with mental health concerns such as anxiety and wellbeing, but specific symptoms of neuropathic pain have had much less attention than the construct as a whole. Paresthesia, meaning “abnormal sensation” (tingling, numbness, pins and needles, impaired sensation, and itching) is a neuropathic pain symptom. Tissue compression is the most common cause of peripheral neuropathy (PN) as well as paresthesia. This study aimed to test the following hypotheses: (1) if paresthesia due to PN is positively correlated with anxiety, negatively correlated with wellbeing, and if (2) anxiety and (3) wellbeing varied significantly by level of …

Pharmacokinetic Modeling Of Metonitazene And Isotonitazene Using In Vitro And In Vivo Models And Comparison To Human Postmortem Casework, Justine P. Sorrentino

Theses and Dissertations

Metonitazene and isotonitazene are two benzimidazole opioids that are contributing to the opioid crisis nationwide. Limited pharmacokinetic data has been published on these nitazene compounds, therefore this study sought to determine if these two structurally similar opioids would have comparable half-lives and clearance utilizing in vitro and in vivo models. Using the data determined in the pharmacokinetic study, and by testing human postmortem cases, this study aimed to inform interpretation of these drugs detected in human casework. Sample analysis for all aspects of the study was performed utilizing LC/MS/MS. In vitro pharmacokinetics of both drugs were examined using a human …

Streptozotocin-Induced Diabetes Increases Kidney Toxicity In Rats Exposed To Ochratoxin A, Belkys Gonzalez

Theses and Dissertations

Due to the rising occurrence of diabetes in the population and the prevalence of OTA exposure via ingestion of contaminated foodstuffs, there is a need to assess the possible renal interaction of a diabetic disease state in concurrence with OTA exposure. Sprague Dawley rats were treated with streptozotocin to induce experimental diabetes and then orally exposed to 0.5 mg/kg body weight OTA once a day for 21 days. Renal biomarkers and light microscopy were evaluated to assess the interaction between diabetic nephropathy and OTA exposure. LLC-PK1 proximal tubule cells were used as an in vitro model to assess the potential …

Exposure To Dithiocarbamate Fungicide Ziram Results In Hepatic And Renal Toxicity In Long-Evan Rats, Jeffrey Chen

Theses and Dissertations

Ziram is a broad spectrum fungicide that is used on a variety of crops. It has been shown to display a wide array of toxicological effects, however, there is still a scarcity of mechanistic data regarding how it facilitates those effects. One of its presumed mechanisms of toxicity is due to the production of oxidative stress. However, whether the production of oxidative stress is due to its dimethyldithiocarbamate backbone, its metal moiety, or a combination of both, is still unknown. Contributing to the production of oxidative stress is ziram’s ability to alter essential metal homeostasis through transchelation of other essential …

Defining Scribbles: How Do Early Childhood Teachers Perceive Scribbles As A Part Of Emergent Literacy?, Sandy Dellalonga

Theses and Dissertations

The purpose of this qualitative, phenomenological study was to understand early childhood teachers’ perceptions surrounding the topic of childhood scribbles as they relate to emergent literacy. Sociocultural theory provided a foundation for this research because of its focus on relationships between children, other children, and teachers to foster learning experiences (Gee, 2011; Vygotsky, 1978, 1998). Additionally, social semiotic theory also guided this research because childhood scribbles represent children’s “signs” which can also influence communication and literacy skills (Kress, 1997). The participants were nine preschool, transitional kindergarten, kindergarten, and first grade teachers (N=9) who volunteered to complete an open-ended survey, follow-up …