Digital Commons Network^™

Pathological Upregulation Of A Calcium-Stimulated Phosphatase, Calcineurin, In Two Models Of Neuronal Injury, Jonathan Elledge Kurz

Theses and Dissertations

Excitotoxic calcium influx and activation of calcium-regulated systems is a common event in several types of neuronal injury. This mechanism has been the focus of intense research, with the hope that a more complete understanding of how neuronal injury affects calcium-regulated systems will provide effective treatment options. This study examines one such calcium-stimulated enzyme, calcineurin, in the context of two common neurological pathologies, status epilepticus and traumatic brain injury.Status epilepticus was induced by pilocarpine injection. NMDA-dependent increases in calcineurin activity were observed in cortical and hippocampal homogenates. Upon closer examination, the most profound increases in activity were found to be …

The Oldest Well, Saul Benjamin Becker

Theses and Dissertations

This body of work, representing the past two years, is focused on the idea of the composite landscape. This reconfiguring of the elements from the external world combined with invented places is a way for me to articulate the subtle transactions between the interior psyche and the external world. The way this new conglomerate space is represented is a result of my inquiry into the relationship between nature, culture, and the sublime. The place where the private acts of the studio meet the shared exterior world is where I find my intellect, fantasy, and sense of reality collaborating in chorus.

A Longitudinal Investigation Of Cognitive Predictors Of Self-Care Behaviors In Youth With Type I Diabetes, Michelle Marie Greene

Theses and Dissertations

Cross-sectional research of youth with type I diabetes has demonstrated that rote and working memory predict blood glucose monitoring (BGM) and carbohydrate consumption, respectively; however, to date, no longitudinal follow-up studies exist. Rote and working memory subtests from well-standardized memory measures, along with a problem-solving and executive functioning measures were administered to 118 youth with type I diabetes, aged 9-16 in two waves of data collection (mean interval = 2.07 years). Diabetes care behaviors were assessed through the 24-hour Diabetes Interview. This study was the first to document longitudinal prediction of BGM by rote memory and fat consumption by working …

Textural Diversity, Paul Eskew

Theses and Dissertations

The sculptures I create reflect the elements of the natural world such as trees, the lumpy bush, clumps of turf. They have imperfect yet fascinating textures, picturesque in form, seemingly fractal in design, working together harmoniously to serve the aesthetic. My sculptures, like these natural shapes, are heavy or thicker toward the bottom and lighter toward the top, like a tree or stone. I strive to echo the mercurial, the animated natural surfaces, and the enticing vignettes one would experience on a woodland stroll.

Bitterroot Landing: An Adaptation From Novel To Stage, Christy Leake

Theses and Dissertations

My thesis explores the process involved in adapting Sheri Reynolds' novel, Bitterroot Landing, into a stage play. During the adaptation process I faced numerous challenges, including structural issues, expanding or changing dialogue, omitting or melding scenes and characters, and dealing with the serious themes of incest and sexual abuse. This thesis describes these challenges and the steps I took to overcome them.

A Gis And Remote Sensing Based Analysis Of Impervious Surface Influences On Bald Eagle (Haliaeetus Leucocephalus) Nest Presence In The Virginia Portion Of The Chesapeake Bay, Jennifer M. Ciminelli

Theses and Dissertations

GIS (Geographic Information Systems) and remote sensing techniques were used to predict relationships between bald eagle nest presences and land type, distance to land type and impervious surface cover area. Data plots revealed bald eagle nest presence decreases in response to an increase in area of bareland; increases with an increase in area of forested land; decreases with an increase in distance (m) to shoreline, and decreases in response to an increase in area of impervious surfaces. Logistic regression models identified impervious surfaces as an indicator for bald eagle nest presence (P 24% as unsuitable. Unsuitable area covered 17.82% of …

Journeys, Diane Rohman

Theses and Dissertations

My art is about journeys, mapping, and layering. Two archetypal images in my work are the camel and the desert. Much of this imagery was inspired by my personal journey over the Sahara and into Western Africa. On another level, this journey connects to my metaphorical journey through life. As a printmaker, my art is very process oriented. Printmaking itself can be thought of as a kind of journey. My trip or the process is more important than the destination or the final result. Like the desert, my images are constantly shifting and transforming through the process of working. Printmaking …

The Role Of Gonadal Hormones On Opioid Receptor Protein Density In Arthritic Rats, Matthew Kren

Theses and Dissertations

The majority of research on the endogenous opioid system has focused on various pain assays and the efficacy of different opioid agonists. However, minimal attention has been focused on the effects of gonadal hormones and their impact on the opioid peptide system. The present study was designed to determine the effects of modulation of gonadal hormones on the opioid receptor protein levels in Complete Freund's Adjuvant (CFA)-treated arthritic and non-arthritic male and female Lewis rats. Midbrain and spinal cord tissues were collected for comparison of the μ, δ, and κ receptor protein levels in arthritic and non-arthritic animals. Male gonadectomy …

Ancient West Mexican Sculpture: A Formal And Stylistic Analysis Of Eleven Figures In The Virginia Museum Of Fine Arts, Crista Anne Pack

Theses and Dissertations

The Virginia Museum of Fine Arts (VMFA) has in its collection eleven ancient West Mexican ceramic sculptures. Given that the VMFA's West Mexican Ceramic figure collection has not been included in any extensive study, this thesis serves to provide a critical analysis of these figures through a formal and stylistic approach. These analyses are preceded by a brief history of the West Mexican cultures and highlight the artistic similarities and differences between each region. The primary regions under discussion are Colima, Nayarit, and Jalisco which correspond to modern geopolitical boundaries. Primary sources for these discussions are the figures themselves, while …

Conceptualizing Hoarding Behavior Among Elderly Women: A Mixed-Methods Approach, Susan Jan Murdock

Theses and Dissertations

Hoarding in the community involves substantial cluttering and impaired functioning, often exposing the hoarder to extensive health and safety risks. This research, based on Functionalism social theory, explores the three elements of hoarding—relentless acquisition, intense possessiveness of objects, and a reluctance to discard possessions—as a sociocultural phenomenon. The mixed methods methodology entailed a quantitative study involving a survey completed by 134 adult protective services workers throughout Virginia and a qualitative study of five randomly-selected adult protective services workers who volunteered for in-depth interviews.Findings revealed that adult protective services workers come in contact with very severe cases of hoarding, with over …

Characterization Of The Rank Ligand Positive Giant Cell Found In The Interfacial Membrane, Patrick Emerson Jones

Theses and Dissertations

Aseptic osteolysis is a major complication to total joint arthroplasty requiring several thousand people a year to have to undergo revisions of their joint prosthesis. The formation of the interfacial membrane has been associated with aseptic osteolysis leading to the failure of all types of total joints. Recent evidence suggests that RANKL, a potent activator of bone reabsorption, is present in the interfacial membrane. Prior research in this laboratory to determine the source of RANKL in the interfacial membrane has revealed the presence of intense areas of RANKL concentration in the membrane. These areas of RANKL concentration correspond to multiple …

A Critical Review Of Telomerase Biology And Model Systems For The Study Of Telomerase, Jeremy Charles Aisenberg

Theses and Dissertations

The study of telomere and telomerase biology holds substantial promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, including 95% of all advanced malignancies. Development of effective model systems to elucidate the molecular mechanisms underlying the role of telomeres and telomerase in the processes aging and cancer is of particular importance. While inbred strains of mice have provided a wealth of information for a variety of pathways and diseases, the mouse model …

Images Of Jenny Lind And The Construction Of Identity For The Nineteenth-Century Female Performer, Joanna Elizabeth Penick

Theses and Dissertations

This thesis examines how images of the Swedish singer Jenny Lind worked to distance her from the typical nineteenth-century view. Because of their position within the public sphere, female performers were thought to be sexually available and often had the reputation of prostitute. Lind achieved a level of success that made her one of the most famous women of the mid-nineteenth-century. She was known not only for her talent as a performer but also for her morality and piety. Examining the Lind images in the context of nineteenth-century social codes and feminist theatre history, it becomes evident that Lind was …

Transforming Growth Factor-Β1 (Tgf-Β1) Induces Mast Cell Apoptosis, Farnaz Norozian

Theses and Dissertations

Mast cells are potent effectors of the inflammatory response, playing an important role in atopy, bacterial immunity, and animal models of arthritis, multiple sclerosis, and heart disease. Hence controlling mast cell numbers and responsiveness is essential for preventing inflammatory disease. This work demonstrated that the cytokine TGF-β1 is a potent inducer of mast cell apoptosis, a finding that was consistent for cultured mouse bone marrow-derived mast cells, peritoneal mast cells, and human mast cells. Cell death appeared to be the result of TGF-mediated repression of IL-3 receptor expression and function, leading to mitochondria1 damage and activation of an apoptotic cascade …

Tinged With Fire, Margo J. Nolan

Theses and Dissertations

I have created art that has evolved from my own personal experiences. Life is capricious, and with the changes wrought by age, joy, and grief, I have found this self-referential work inevitable. Here, I have documented the journey that has brought me through personal wars, battles, and truces. I have come to believe that although my individual experiences may be unique, my responses to them are not. Loss and victory are universal.

Delayed Versus Immediate Feedback In An Independent Study High School Setting, Duane C. Lemley

Theses and Dissertations

Although there is general agreement that feedback plays an important role in student performance, the majority of the studies found in the research literature explore the impact of different types of feedback in a traditional and university-level setting. In order to explore the impact of different feedback types in a non-traditional distance learning setting, 352 high school students enrolled in courses offered through BYU's Independent Study (IS) department received either delayed feedback or immediate feedback generated by Speedback™, BYU's automated grading and feedback program, depending on whether they had opted to submit end of unit assignments by mail or …

Toiling Among The Seed Of Israel: A Comparison Of Puritan And Mormon Missions To The Indians, Christina A. Skousen

Theses and Dissertations

Substantial comparative analyses of Puritanism and Mormonism are lacking in historical scholarship, despite noted similarities between the two religions. This study helps to fill that void by comparing the Puritan and Mormon proselytization efforts among the Indians that occurred at the respective sites of Massachusetts Bay Colony and the Southern Indian Mission. In my examination of the missionization attempts that took place at these two locations, I analyze a common motive and method of the two denominations for attempting to Christianize the Indians. The Puritan and Mormon missionaries proselytizing in Massachusetts Bay Colony and the Southern Indian Mission shared an …

Reliability And Validity Of Virtual Build Methodology For Ergonomics Analyses, Tinghao Wu

Theses and Dissertations

This study was conducted to assess the validity and reliability of the Virtual Build methodology for ergonomics design and analysis. Thirty-six human subjects participated in this study and performed a set of six tasks. The tasks were performed twice in both real and virtual environment. The subject?s motion in performing tasks was analyzed by ergonomics assessments by using Virtual Build methodology. Criteria-related validity was evaluated by comparing the Virtual Build ergonomic assessment results with manual calculation. Test-retest reliability was evaluated by correlating ergonomics assessment results between two trials. The result shows that the Virtual Build methodology is reliable for ergonomic …

Two- And Three-Plane Job Risk Classification Using Motion Capture: An Examination Of The Marras Et Al. Model, 1993, Tara Marie Cappelli

Theses and Dissertations

Lower Back Disorders account for 16-19% of work related claims and 33-41% of dollars paid in workers? compensation (as cited in Marras, 1999), with impacts to society approaching $100 billion dollars annually (as cited in Marras et al., 1999). Dr. William Marras engineered a device to track trunk kinematics in order to develop a Job Risk Classification Model for predicting high-risk group probability of lower back injury. The device has been validated, but other technologies such as 3-D motion capture can potentially gather the same data. This study examined the use of motion capture to apply two- and three-plane lifting …

Experimental Study On The Effects Of Operational Parameters Of A Downdraft Gasifier, Lin Wei

Theses and Dissertations

To examine the effects of operational parameters on syn-gas quality and biouel conversion rate under various running conditions, an experimental study of hardwood chip?s gasification in a downdraft gasifier was conducted. The resulting syn-gas had average low heating value of 5.79 ± 0.52 MJ/ Nm3, tar concentration of 14.06 ± 8.54 mg/Nm³, particulate concentration of 3.05 ± 1.79 mg/Nm³, hardwood conversion rate of 2.37±0.24 Nm³/kg, and carbon conversion rate of 98.01 ± 0.53%. This syn-gas is of acceptable quality to be used as a fuel source for internal combustion engine operations. The gasifier?s grate temperature had no evident effects on …

Design Optimization Of A Parallel Hybrid Powertrain Using Derivative-Free Algorithms, Sachin Kumar Porandla

Theses and Dissertations

A Hybrid Electric Vehicle (HEV) is a complex electro-mechanical-chemical system that involves two or more energy sources. The inherent advantages of HEVs are their increased fuel economy, reduced harmful emissions and better vehicle performance. The extent of improvement in fuel economy and vehicle performance greatly depends on selecting optimal component sizes. The complex interaction between the various components makes it difficult to size specific components manually or analytically. So, simulation-based multi-variable design optimization is a possible solution for such kind of system level design problems. The multi-modal, noisy and discontinuous nature of the Hybrid Vehicle design requires the use of …

The Development Of A Methodology For Assessing Industrial Workstations Using Computer-Aided Ergonomics And Digital Human Models, Jinyan Du

Theses and Dissertations

This study examined an existing industrial workstation at an automobile assembly plant using computer aided ergonomics and digital human models. The purpose of this evaluation was the development of a methodology useful for evaluating workstations to identify potential design issues that could result in musculoskeletal injury in a real work environment. An ergonomic risk assessment was conducted on a lifting task while being performed both manually and using an assist device. JACK digital human modeling and ergonomics software were used to conduct a computer-based ergonomic analysis. Four analysis tools in JACK (static strength analysis, rapid upper limb assessment, metabolic energy …

Evaluation Of Chitosan Gelatin Complex Scaffolds For Articular Cartilage Tissue Engineering, Harshal Prabhakar Mahajan

Theses and Dissertations

In search of better scaffolding materials for in vitro culture of chondrocytes, the combination of chitosan (similar to glycosoaminoglycans) and gelatin (denatured collagen) was tested due to its resemblance to cartilage extra-cellular matrix (ECM). Porous scaffolds were fabricated from chitosan gelatin blends (1:1, 2:1, and 3:1). The response of chondrocytes to them was evaluated from the amount of sulphated GAG and collagen type 2 secreted after 3 and 5 weeks. The effect due to static (transwell inserts) and dynamic (rotating bioreactor) culture methods was analyzed. Results indicate that 1:1 chitosan gelatin blends showed the best chondro-conductive potential. The rotating bioreactor …

Biomechanical And Metabolic Changes Within Rabbit Articular Cartilage Following Treatment With Radiofrequency Energy, Christopher Larry Horstman

Theses and Dissertations

The effects caused to articular cartilage by the remote use of arthroscopically-delivered RF energy to soft tissues in the joint are unknown. This investigation reported the short and long-term effects of bRF and mRF energy on the biomechanical properties and metabolic activity of articular cartilage. In addition, the effect of Cosequin® therapy was addressed. Thirty New Zealand white rabbits were randomly assigned to one of two treatment groups (Group 1 - placebo; Group 2 - Cosequin®). Histopathology, cell viability, GAG synthesis, and mechanical function of the articular cartilage were compared between groups. Data were analyzed using a mixed model ANOVA …

Plasma Steroid And Vitellogenin Concentrations, Activity Of Cathepsins, And Egg Protein Content During Oocyte Maturation, And Influence Of Hormone Injection In Four Commercial Strains Of Channel Catfish Ictalurus Punctatus, Marinela Barrero-Monzon

Theses and Dissertations

Profiles of plasma estradiol and testosterone concentrations, cathepsin D, L, and B activities, and quantitative and qualitative protein content were developed and evaluated in four commercial strains of channel catfish, Gold Kist (2), Thompson and NWAC-103 for one year (age 2 to age 3). Great variation between individuals of the same strain precluded the identification of any significant, strain-specific differences for the variables under investigation. When variables from fish of all strains were collectively evaluated over time, both estradiol and testosterone concentrations significantly increased in July and then later from February to April. The increase in hormone concentration was accompanied …

Definition, Analysis, And An Approach For Discrete-Event Simulation Model Interoperability, Tai-Chi Wu

Theses and Dissertations

Even though simulation technology provides great benefits to industry, it is largely underutilized. One of the biggest barriers to utilizing simulation is the lack of interoperability between simulation models. This is especially true when simulation models that need to interact with each other span an enterprise or supply chain. These models are likely to be distributed and developed in disparate simulation application software. In order to analyze the dynamic behavior of the systems they represent, the models must interoperate. However, currently this interoperability is nearly impossible. The interaction of models also refers to the understanding of them among stakeholders in …

Mercury Oxidation By Chlorine-Containing Species And Scrubbing In A Wet Flue Gas Desulfurization System, Yongxin Zhao

Theses and Dissertations

This research is particularly related to mercury control technologies. The state of the art in mercury emission control is generally classified into two categories: Mercury Transformation and Mercury Capture. In this research, two chapters (3 & 4) are specifically related to mercury transformation and another two (5 & 6) are related to mercury capture.

Chapter 3 investigates the capabilities of HCI and CU on Hg° oxidation. The resulting data indicated that both were effective in the combustor. However, HCI was less effective in a quartz reactor. Subsequently, the inhibitory effects of NO and S02 were identified in the quartz reactor. …

Breakage Studies On French Fries, Kaylan Dittakavi

Theses and Dissertations

This paper is a case study of French fry potato processing at the JR Simplot Food Group facility, Grand Forks, No1th Dakota. Broken French fries potentially reduce customer satisfaction with increased overhead costs to the company. This study examined a six-month on-site field investigation focusing on breakage of samples collected at different sample points for different types of cuts in the French fries processing

The purpose of this study was to analyze and evaluate the percentage of the breakage occu1Ted on French fries at different sample points for different types of cuts throughout the French fries process. Thereby conclude the …

An Examination Of The Perceived College Leadership, Governance, And Decision Making From Governing Board Members At Selected Midwest Tribal Colleges, William L. Gourneau

Theses and Dissertations

Traditional American Indian leadership was the foundation of today‘s Indian leadership. The belief in the Indian value system, which was integrated throughout traditional leadership, has greatly contributed to leadership qualities for Indian people. A change in how Native Americans interpret Indian leadership began with the introduction of tribal governments. Tribal governments forced Indian people into a different form of leadership. Although new leadership roles came into existence, the concept of traditional leadership continued. Many current tribal leaders were looked upon favorably if they possess traditional cultural values. Even today, elders and community members with strong cultural knowledge are sought out …

Cornelius P. Lott And His Contribution To The Temporal Salvation Of The Latter-Day Saint Pioneers Through The Care Of Livestock, Gary S. Ford

Theses and Dissertations

This thesis combines two studies: the role of livestock in the temporal salvation of The Church of Jesus Christ of Latter-day Saints in the Mormon exodus of 1846 and Cornelius P. Lott's contribution in the care of cattle and sheep during that time period. At Winter Quarters, the Church and its members depended in large measure for their survival upon the sizeable cattle herds they had acquired prior to their exodus from Nauvoo and during their trek across Iowa. Church leaders relied on men like Lott, whose expertise in the care of livestock, contributed significantly to the salvation of the …