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Particle Image Velocimetry Measurements Of The Total Cavopulmonary Connection With Circulatory Flow Augmentation, Steven Chopski Apr 2010

Particle Image Velocimetry Measurements Of The Total Cavopulmonary Connection With Circulatory Flow Augmentation, Steven Chopski

Theses and Dissertations

This thesis project examined the interactive fluid dynamics between a blood pump and the univentricular Fontan circulation. 2-D particle image velocimetry (PIV) measurements were conducted on an idealized total cavopulmonary connection (TCPC) with an axial pump prototype in the inferior vena cava (IVC). Fluid velocity profiles were examined under various physiologic conditions for Fontan patients. The velocity profiles for all cases demonstrated the shunting of flow from the IVC toward the right pulmonary artery. A rotational component in the pump outflow was observed forcing flow to the periphery as compared to the flow profile without a pump present in the …

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Epicene Pronoun Use In Modern American English, Robin Montgomery Watson Apr 2010

Epicene Pronoun Use In Modern American English, Robin Montgomery Watson

Theses and Dissertations

Traditional prescriptive grammar for English states that the epicene or gender neutral pronoun for third person singular use is he. Research into speaker perceptions has clearly demonstrated that he is not perceived as neutral. Research has also shown traditionally proscribed epicene pronouns such as he or she and singular they to be commonly used, despite the long-standing proscriptions against them. The author examines the endurance of such proscribed options through the lens of markedness theory, considering the impact of cultural values on speakers' epicene pronoun choices. Gender in language is also considered, as well as Kuryłowicz‘s 4th Law of …

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Development Of Mechanical Cardiovascular Assist Devices For Fontan Patients: Two Novel Approaches, Sonya Bhavsar Apr 2010

Development Of Mechanical Cardiovascular Assist Devices For Fontan Patients: Two Novel Approaches, Sonya Bhavsar

Theses and Dissertations

Few therapeutic alternatives exist for patients with a failing single ventricle physiology. To address this need, this thesis project investigated two new therapeutic alternatives, which sought to positively augment the Fontan hemodynamics. The first modality introduced a non-invasive method of external pressure application to the lower extremities. A clinical study (n=2) was conducted, and results indicated an increase in flow as a consequence to an increase in transmural pressure in the lower extremities. The second modality investigated a minimally invasive blood pump. Numerical analyses of the pump were performed to examine hydraulic performance under physiologic conditions. The pump produced pressure …

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Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg Apr 2010

Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg

Theses and Dissertations

While there is currently active debate over possible therapeutic applications of marijuana and cannabis-based compounds, consistently their primary drawbacks have been the psychoactive properties, dependence, and abuse potential. Prolonged administration of ∆9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, demonstrates both tolerance and physical withdrawal in both preclinical and clinical studies. Repeated THC administration also produces CB1 receptor adaptations in the form of reduced activation of receptors, along with a downregulation of membrane surface receptors, in many brain regions involved in THC-associated behaviors. The increased need for drug to maintain therapeutic effects, and a withdrawal syndrome following discontinuation of use, …

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Research And Interpretive Plan For The First Permanent Exhibition Of Ancient American Art At The Virginia Museum Of Fine Arts, Amy Lenhardt Apr 2010

Research And Interpretive Plan For The First Permanent Exhibition Of Ancient American Art At The Virginia Museum Of Fine Arts, Amy Lenhardt

Theses and Dissertations

The Virginia Museum of Fine Arts (VMFA) of Richmond, Virginia, is completing its largest expansion and reinstalling over 6000 artworks, including the Ancient American art collection, to be displayed in the museum’s first permanent gallery space for Ancient American art. In preparation for expansion, the VMFA issued its “Interpretive Plan Guiding Principles,” identifying visitor motivations for viewing the collections. As collection accessibility is central to the museum’s mission statement, all galleries are to provide visitors with the tools to engage with artworks. This thesis project presents a comprehensive history of Pre-Columbian collecting in museums and the history of the VMFA …

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Diet Reconstruction Of Bighorn Sheep (Ovis Canadensis) Using Stable Isotopes, Joshua M. Whitaker Apr 2010

Diet Reconstruction Of Bighorn Sheep (Ovis Canadensis) Using Stable Isotopes, Joshua M. Whitaker

Theses and Dissertations

We determined the diet contributions of grasses, forbs and shrubs for three herds of bighorn sheep along the Wasatch Front, Utah using stable isotope techniques and determined the electivity values for different forage species for four herds. Forbs were generally the most common forage eaten across all herds while shrubs were the least used forage resource. The Provo Peak and Mount Nebo herds used grasses, forbs and shrubs at proportions similar to other bighorn sheep populations across the west, while the Antelope Island herd used forbs at higher levels than any other local herd. Additionally, the herd on Antelope Island …

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Predicting Functional Protein Complexes In The Glycolytic Pathway: Computer Simulations Of Compartmentation And Channeling In Glycolysis, Neville Y. Forlemu Apr 2010

Predicting Functional Protein Complexes In The Glycolytic Pathway: Computer Simulations Of Compartmentation And Channeling In Glycolysis, Neville Y. Forlemu

Theses and Dissertations

Functional protein-protein interactions are essential for many physiological processes. For example, the association of glycolytic enzymes to F-actin is proposed to be one mechanism through which glycolytic enzymes are compartmentalized, and as a result, plays essential roles such as regulation of the glycolytic pathway, substrate channeling and increasing glycolytic flux. An accurate molecular picture describing such interaction, however, is not yet generalized. Similarly, questions about the specificity and extensive nature of such functional complexes in a variety of cells, tissues, or organisms, still remain ambiguous. Examination of these interactions in various animal species tests this hypothesis by observing whether binding …

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Basal And Metal-Induced Expression Of Metallothionein And Zinc Transporters In The Rwpe-1 Human Prostate Epithelial Cell Line, Amy L. Albrecht Apr 2010

Basal And Metal-Induced Expression Of Metallothionein And Zinc Transporters In The Rwpe-1 Human Prostate Epithelial Cell Line, Amy L. Albrecht

Theses and Dissertations

Prostate cancer is a leading cause of death among men world wide; while prostate cancer has many factors leading to its development; one such factor is cadmium exposure. Cadmium is a known human carcinogen and is an environmental factor that has been linked with prostate cancer progression. Metallothionein (MT) is a cadmium binding protein that is expressed within human tissues that may play a role in prostate carcinogenesis. Zinc is an important metal within the body and the prostate contains high levels of this metal within the cytosol of the cells, whereas the prostate cancer cells do not retain this …

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Adrenergic Receptor Modulation Of Hippocampal Ca3 Network Activity, Christopher W. D. Jurgens Apr 2010

Adrenergic Receptor Modulation Of Hippocampal Ca3 Network Activity, Christopher W. D. Jurgens

Theses and Dissertations

Norepinephrine (NE) is an endogenous neurotransmitter distributed throughout the mammalian brain. NE has demonstrated proconvulsant and antiepileptic properties. In higher cortical structures such as the hippocampus, a region often involved in temporal lobe epilepsy, NE has been shown to reinforce the cognitive processes of attention and memory. However, the specific mechanism of these actions has not been clearly established. To address this, the effects of NE were studied on hippocampal CA3 network activity. Frequency changes of burst discharges in response to NE were biphasic; low concentrations increased the number of bursts, while higher concentrations suppressed the number of bursts, suggesting …

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Even Satan Spoke Hebrew, Gilad Elbom Apr 2010

Even Satan Spoke Hebrew, Gilad Elbom

Theses and Dissertations

A novel preceded by a scholarly introduction, EVEN SATAN SPOKE HEBREW employs a variety of metafictional devices—collage, appropriation, borrowing, minoring, framing, indeterminacy, textual parody, obtrusive narration, structural constraints—in an attempt to propose a deliberate departure from the concepts of mimetic art, verisimilitude, and believability. Set in Jerusalem and Los Angeles, it revolves around an aspiring writer who insists on working in a foreign language, a self-professed exile accused of betraying her homeland, national identity, and mother tongue. When her first novel disappears—somehow she manages to misplace the only copy of her manuscript—she embarks on an intertextual journey in search of …

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App Is A Novel Proinflammatory Receptor On Vascular Endothelium That Is Involved In The Vascular Dysfunction Associated With Atherosclerosis And Ad, Susan A. Austin Apr 2010

App Is A Novel Proinflammatory Receptor On Vascular Endothelium That Is Involved In The Vascular Dysfunction Associated With Atherosclerosis And Ad, Susan A. Austin

Theses and Dissertations

Amyloid precursor protein (APP) is a ubiquitously expressed type one integral membrane protein. Due to its ability to bind components of the extracellular matrix and propagate signaling responses via its cytoplasmic phosphotyrosine binding motif it has been suggested to function in cellular adhesion. Here, we utilized brain tissue and aorta from human and apolipoprotein E -/- (apoE-/-) mice to examine vascular inflammation associated changes related to APP. We also examined AD brain tissue for similar changes. Human atherosclerotic aorta, human AD cerebrovasculature and mouse apoE-/- aorta and cerebrovasculature revealed strong endothelial immunoreactivity for APP, APP phosphorylated at tyrosine residue 682 …

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Role Of Dendritic Cells In Spontaneous Polychondritis: Pathogenesis And Prevention, Maninder Sidhu Apr 2010

Role Of Dendritic Cells In Spontaneous Polychondritis: Pathogenesis And Prevention, Maninder Sidhu

Theses and Dissertations

Spontaneous polyarthritis (SA) is an autoimmune disease that develops spontaneously at 4 months of age in the HLA-DQ6αβ8αβ double transgenic (tg) mice. The disease is characterized by lymphocyte infiltration in joints leading to chronic polyarthritis in the extremities similar to human rheumatoid arthritis. Immature dendritic cells (iDCs) have a tolerogenic potential due to low expression of important costimulatory cell surface molecules required for antigen presentation and induction of an effective immune response. In this study it has been shown that injection of iDCs pulsed with chick type II collagen (CII) significantly delayed the onset and suppressed the severity of SA …

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From The Old To The New World: The Transformation Of Kongo Minkisi In African American Art, Mary Mccurnin Apr 2010

From The Old To The New World: The Transformation Of Kongo Minkisi In African American Art, Mary Mccurnin

Theses and Dissertations

Minkisi (sing. nkisi) were sacred objects that housed ancestral spirits and were used for divination, healing and social justice by the Kongo people of Central Africa. When the Kongo were brought as slaves to the New World, they contributed significantly to the development of African American artistic and spiritual culture. In the Caribbean, aspects of minkisi have been retained in the creolized spiritual beliefs of Haitian Vodou, Cuban Palo Monte Mayombe and Brazilian Candomble. In North America, evidence of Kongo influence is apparent in examples of folk art and culture, including quilts, mojo hands, Afro-Carolinian face vessels, memory jugs and …

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Breaking Art Apart, Michael Gettings Apr 2010

Breaking Art Apart, Michael Gettings

Theses and Dissertations

The human figure, allegory, myth, and the appropriation of other artist’s compositions are elements in my work. I aim to update traditional stories to conform to contemporary times and culture. In addition, I am striving to create a new method to visually express figurative storytelling. Breaking from the traditional flat painting surface, I use multiple shaped panels. The surface is broken into different shaped panels at varying distances from each other and from the wall. This allows for more exploration into shape and negative space while depicting the dramatic height of a story. As part of this method, my paintings …

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Modulation Of Cocaine-Like Behavioural Activity By Serotonin Uptake Inhibition Relative To The Effects Of The Novel And Selective Dopamine Transporter Inhibitor, D-84, Angela Batman Apr 2010

Modulation Of Cocaine-Like Behavioural Activity By Serotonin Uptake Inhibition Relative To The Effects Of The Novel And Selective Dopamine Transporter Inhibitor, D-84, Angela Batman

Theses and Dissertations

Cocaine dependence is a major health concern worldwide, but despite this high rate of abuse there are currently no approved therapies for cocaine dependence. Replacement pharmacotherapies are one possible approach for treating cocaine dependence, and identification of such therapeutics for cocaine abuse is the long-term goal of this research. Cocaine binds to, and inhibits uptake at the dopamine (DAT), serotonergic (SERT) and noradrenaline (NET) uptake transporters, but studies have shown that cocaine produces its strong behavioural and positive reinforcing effects through inhibition of the DAT. To this end a great number of diverse, non-selective DAT-inhibiting compounds have been investigated as …

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Perifosine, A Novel Akt Inhibitor Induces Apoptosis, Cell Cycle Arrest And Has A Chemo-Sensitizing Effect In Medulloblastoma Cell Lines, Anil Kumar Apr 2010

Perifosine, A Novel Akt Inhibitor Induces Apoptosis, Cell Cycle Arrest And Has A Chemo-Sensitizing Effect In Medulloblastoma Cell Lines, Anil Kumar

Theses and Dissertations

Primary central nervous system (CNS) tumors are the most common solid tumors found in children. While surgery and radiotherapy still remain the standard treatment modalities in pediatric brain tumors, chemotherapy also has an important part in the management of these tumors. However, most of the available chemotherapeutic drugs have suboptimal effectiveness. Deregulation of various pro-apoptotic and anti-apoptotic pathways has been cited as a major mechanism underlying this drug resistance. The role of various serine threonine kinases, including Akt kinases, in promoting drug resistance is being extensively studied in various cancers. A complete understanding of the molecular mechanisms that underlie drug …

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The Influences Of Matrix Metalloproteinase-1 Expression On Glioblastoma Pathology, Nicholas Pullen Mar 2010

The Influences Of Matrix Metalloproteinase-1 Expression On Glioblastoma Pathology, Nicholas Pullen

Theses and Dissertations

Glioblastoma multiforme (GBM) is an aggressive central nervous system (CNS) cancer characterized by enhanced tumor cell motility, pernicious invasion into the normal brain, extensive tumor-induced angiogenesis, and adaptive resistance to current therapeutic paradigms. One of the difficulties associated with GBM is the ability of the tumor cells to infiltrate normal CNS tissue. Neurosurgeons can remove the primary tumor mass, but peripheral cells that are inaccessible will ultimately result in a secondary lesion that can lead to death. The matrix metalloproteinases (MMP) are well known for their abilities to facilitate processes of cellular motility and invasion through their clearance of extracellular …

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Size-Structured Competition And Predation In Red-Eyed Treefrog Tadpoles, Christopher Asquith Mar 2010

Size-Structured Competition And Predation In Red-Eyed Treefrog Tadpoles, Christopher Asquith

Theses and Dissertations

Body size is important in determining the outcome of competition and predator-prey interactions. Size structure of a population (i.e. relative proportion of large and small conspecifics) may be particularly important in organisms with prolonged breeding periods and rapid growth where populations may have multiple cohorts at different stages of development competing for one resource. Both the consumptive and nonconsumptive effects of predators can also be size-dependent and can alter competitive interactions. Here we study the importance of size structure in the Neotropical leaf-breeding tree frog, Agalychnis callidryas. This species is a prolonged breeder such that multiple overlapping cohorts of differing …

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An Examination Of The Dna Content, Taxonomy And Phylogeny Of Penstemon (Plantaginaceae), Shaun R. Broderick Mar 2010

An Examination Of The Dna Content, Taxonomy And Phylogeny Of Penstemon (Plantaginaceae), Shaun R. Broderick

Theses and Dissertations

Penstemon is the largest genus in North America with more than 270 reported species. However, little is known about the genome size of this genus and how this information may be useful in selecting species in developing hybrids for landscape use. Using flow cytometry, we estimated the genome size of approximately 40% of the genus (117 specimens from 104 different species.) Genome sizes for the putative diploids ranged from 2C = 0.94 – 1.89 pg (1C = 462 – 924 Mbp) and the putative polyploids ranged from 2.57 – 6.54 pg (1C = 1,257 – 3,156 Mbp). Chromosome counts were …

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Development And Use Of Microsatellite Markers For Genetic Diversity Analysis Of Canahua (Chenopodium Pallidicaule Aellen), Amalia Vargas Mar 2010

Development And Use Of Microsatellite Markers For Genetic Diversity Analysis Of Canahua (Chenopodium Pallidicaule Aellen), Amalia Vargas

Theses and Dissertations

Cañahua (Chenopodium pallidicaule Aellen) is a poorly studied, annual subsistence crop of the high Andes of South America. Its nutritionally value (high in protein and mineral content) and ability to thrive in harsh climates (drought, extreme elevations, etc.) make it an important regional food crop throughout the Andean region. The objectives of this study were to develop genetic markers and to quantify genetic diversity within cañahua. A set of 43 wild and cultivated cañahua genotypes and two related species (C. quinoa and C. petiolare) were evaluated for polymorphism using 192 microsatellite markers derived from random genomic …

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Ghouls, Hell And Transcendence: The Zombie In Popular Culture From "Night Of The Living Dead" To "Shaun Of The Dead", Jasie Stokes Mar 2010

Ghouls, Hell And Transcendence: The Zombie In Popular Culture From "Night Of The Living Dead" To "Shaun Of The Dead", Jasie Stokes

Theses and Dissertations

Considering the amount of media created around the zombie and the sustained interest in its role in our society, we can clearly see that a cultural phenomenon is underway, and it is important for us to question this phenomenon in order to gain some understanding of how and why its appeal has stretched so far. The zombie is somehow enthralling, and it is my opinion that this is in part because the zombie is a study of what it means to be human in the postmodern world. My main purpose here is not to ask why zombies are popular or …

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Leland F. Prince's Earth Divers, Leland Fred Prince Mar 2010

Leland F. Prince's Earth Divers, Leland Fred Prince

Theses and Dissertations

My stoneware sculptures in my MFA final project were named Earth Divers because clay as a material is earth and clay is also symbolic of the Earth. The way that I physically dive into clay up to my elbows is a poetic performance. The sculptures were built in sections horizontally and then stacked vertically. I began the process by first making life size plaster molds of the human figure taken from live people. Earth Divers take their architectural structure specifically from the organic curves of the negative voids that are characteristic of the plaster figure molds. I built into these …

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Ground Reaction Forces Generated By Twenty-Eight Common Hatha Yoga Postures, Sylvia Joan Wilcox Mar 2010

Ground Reaction Forces Generated By Twenty-Eight Common Hatha Yoga Postures, Sylvia Joan Wilcox

Theses and Dissertations

Yoga adherents claim many benefits of the practice, including promotion of bone health and prevention of osteoporosis. However, few, if any, studies have investigated whether yoga enhances bone mineral density. Furthermore, none have identified force generation in yoga. The purpose of this study is to collect ground reaction force (GRF) data on a variety of common hatha yoga postures that would be practiced in fitness centers or private studios. Twelve female and eight male volunteers performed a sequence of 28 common hatha yoga postures while ground reaction force data were collected with an AMTI strain-gauge force plate. The sequence was …

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The Absurd In The Briar Patch: Ellison's Invisible Man And Existentialism, Eliot J. Wilcox Mar 2010

The Absurd In The Briar Patch: Ellison's Invisible Man And Existentialism, Eliot J. Wilcox

Theses and Dissertations

This article claims that Ralph Ellison's use and then revision of French existential themes is essential to understanding his overriding message of Invisible Man: Ellison's hope for a more polyglot American democracy that transcends the white democracy of mid twentieth century America. Specifically, I argue that Ellison, after demonstrating his ability to understand and engage in the traditional ideology of European existentialism, deviates from its individualistic conclusions demanding that the larger community, not just the solitary individual, must become ethically responsible if the classic existential tenet of authenticity is to be achieved. In order to establish this claim, I …

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Are Impact Factors Comparable? Impact Factor Comparisons Across Areas Of Psychology, Jason J. Van Der Horst Mar 2010

Are Impact Factors Comparable? Impact Factor Comparisons Across Areas Of Psychology, Jason J. Van Der Horst

Theses and Dissertations

Journal impact factors play an increasing role in academics as a tool for evaluating faculty, research, and resource allocations. These evaluations may be effective in departments where the subject matter is reasonably unified. However, given the diversity found within the subject matter of psychology, the impact factors of journals may not be comparable across the various areas. This study compares the average impact factors across decile levels of journals from seven areas of psychology. It is found that impact factor scores are not comparable across the seven areas of psychology. This difference is more pronounced when looking at higher decile …

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Diversity And Abundance Of The Dark Kangaroo Mouse, Microdipodops Megacephalus, In Communities Of Nocturnal Granivorous Rodents In Western North America, Ashley Sagers Haug Mar 2010

Diversity And Abundance Of The Dark Kangaroo Mouse, Microdipodops Megacephalus, In Communities Of Nocturnal Granivorous Rodents In Western North America, Ashley Sagers Haug

Theses and Dissertations

The dark kangaroo mouse, Microdipodops megacephalus, is a sensitive species in the Great Basin Desert. This thesis explores the structure of desert rodent communities of the Great Basin to better understand M. megacephalus' place in the community and the conditions that promote large and stable populations. To determine community structure, I used nestedness analysis to evaluate 99 communities of nocturnal granivorous rodents. I found that the community structure was non-random, indicating the existence of assembly rules and ecological constraints. I also found that M. megacephalus was the second most vulnerable species in the community. To explore the correlation …

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Diet Reconstruction Of Wild Rio-Grande Turkey Of Central Utah Using Stable Isotope Analysis, Benjamin D. Stearns Mar 2010

Diet Reconstruction Of Wild Rio-Grande Turkey Of Central Utah Using Stable Isotope Analysis, Benjamin D. Stearns

Theses and Dissertations

The wild turkey is endemic to North America and has played a role in human cultures past and present. However, with the turkey's elusive behavior some aspects of its ecology are challenging to understand. Diet is one of these difficult aspects to study. The purpose of this study was to determine the diet selection of wild turkeys in central Utah using non invasive stable isotope technology. We hypothesize that turkey diet is highly specific, that consumption of specific plant species correlates with the needs of the individual turkey, and that stable isotope analysis will reveal patterns in annual dietary intake. …

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La Misogynie À Visage Féminin: Hircan's Role As Marguerite's Anti-Feminist Voice In The Heptaméron (Vii & Xlix), Gregory Richard Jackson Mar 2010

La Misogynie À Visage Féminin: Hircan's Role As Marguerite's Anti-Feminist Voice In The Heptaméron (Vii & Xlix), Gregory Richard Jackson

Theses and Dissertations

The following document is a meta-commentary on the article, "La misogynie à visage féminin: Hircan's Role as Marguerite's Anti-feminist Voice in the Heptaméron (VII & XLIX)," co-authored by Dr. Robert J. Hudson and myself, which will shortly be submitted for publication. It contains an annotated bibliography of all our primary and secondary sources and an account of writing the article. Our article examines what Marguerite de Navarre, the sixteenth-century French Renaissance author of the Heptaméron (a collection 72 nouvelles, all supposedly true stories being told by a group of ten devisants to one another), intended by her …

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The Level Of The Beasts That Perish: Animalized Text In Charlotte Elizabeth Tonna's Helen Fleetwood, Christie Anne Peterson Mar 2010

The Level Of The Beasts That Perish: Animalized Text In Charlotte Elizabeth Tonna's Helen Fleetwood, Christie Anne Peterson

Theses and Dissertations

Although Charlotte Elizabeth Tonna's 1839 social reform novel Helen Fleetwood has long been understood as a commentary on the dehumanizing effects of factory work, her use of animals to represent factory workers has not been considered in analyses of her depictions of dehumanization. Considering both the growing interest in the animal/human divide during the early nineteenth century and Tonna's own direct contributions to discussions about animals, in this essay I examine the role that animals play in negotiating definitions of humanity and nature in the novel. I argue that idealized, "Edenic" animals and corrupted, "industrial" animals are integral to Tonna's …

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In My Busby Berkeley Dreams, Michael Pierce Mar 2010

In My Busby Berkeley Dreams, Michael Pierce

Theses and Dissertations

I use high- and low-tech approaches in my drawings and bookart to address issues of sexual identity and beauty. My work emphasizes process, content, and image. I create pictures using tightly cropped symbolic figurative imagery. I also leave smudges, smears, and traces of what happened in the making of the work to make process more visible. In my work I would like you to consider what you see and what you don’t see, to smile in recognition of something you might never have really thought about before. And when I really get it right, you might even question your own …

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