Digital Commons Network^™

Exploring The Potential Pathogenicity Of A Type 2 Diabetes Mellitus Associated Insr Missense Variant Of Uncertain Significance Through Daf-2 In The Caenorhabditis Elegans Model, Brittany White

Theses

Type 2 diabetes mellitus (T2DM) is hallmarked by insulin resistance, with the INSR gene identified as a key player in this condition in humans. This gene is known to harbor genetic variants with a wide range of clinical significance from pathogenic to variants of uncertain significance (VUS) to benign. This project investigates a VUS associated with T2DM identified through ClinVar. A gene mutational analysis, predictive amino acid substitution analysis, and protein modeling predict INSR c.1628C>T (p. Thr543Met) to be likely pathogenic or damaging. PolyPhen-2 predicts this variant to be probably damaging (HumDiv score of 1.000).

Evolutionary conservation of the …

Genetic Analysis Of Hereditary Gingival Fibromatosis Associated Sos1 Missense Variants Of Uncertain Significance In Caenorhabditis Elegans, Himani Patel

Theses

Hereditary gingival fibromatosis (HGF) is a disease that can present as benign overgrowth of gingival tissue in the mouth. The overgrowth can enclose the entire mouth and teeth in severe cases or present itself in a concentrated area. Researchers have identified that mutations in the SOS1 gene can be responsible for HGF. This disease can impair basic functions related to the mouth. Eating, smiling, speaking can all be affected. Additionally, excess inflammation can cause periodontal disease because of the difficulty in maintaining proper oral health. Periodontal disease can lead to severe bone loss which can lead to complete loss of …

The Ghanaian War Against Malaria: A Geospatial Approach To Malaria And Healthcare Access In Ghana, Emmanuel Aklie

Theses

This geospatial research project aims to analyze the complex factors influencing malaria incidence in Ghana, including healthcare access, cultural beliefs, and preventive measures. Using GIS mapping and spatial analysis, the study examines malaria distribution and healthcare facility locations to identify hotspots and access inequalities. Combining quantitative data from sources like Demographic and Health Surveys with qualitative methods like surveys and interviews, the project analyzes the relationship between malaria prevalence and vaccination rates, bed net usage, and cultural views on treatment. By taking a comprehensive approach focused on evidence-based insights, the research seeks to inform targeted interventions by the Ghanaian government …

Satellite-Based Spatial And Temporal Characterization Of Rainfall Over The Uae, Yassin Ibrahim Ahmad

Theses

Studies on rainfall characteristics have been of particular interest in the arid and semi-arid regions, including the United Arab Emirates (UAE), due to its impact on the built and natural environment. Rainfall represents a vital water source and a potential threat to the built environment, particularly during flash rainfall. This thesis evaluates spatial and temporal variation of rainfall in the UAE. The UAE is classified into four ecosystems with a distinct distribution of precipitation (East Coast, Mountains, the Gravel Plains, and Desert Foreland). Satellite data on daily rainfall for the years starting from 2001 up to 2020 was obtained from …

Phytochemical Analysis, Antioxidant, And Anti-Breast Cancer Evaluation Of Haplophyllum Tuberculatum, A Medicinal Plant Native To The Emirate Of Ras Al Khaimah, Uae, Aaesha Mohammad Adam

Theses

Breast cancer (BC) emerges as the prevailing cancer type diagnosed in women, with more than 2 million new cases documented in 2020 worldwide. BC is the third leading cause of death after cardiovascular diseases and injuries in the United Arab Emirates (UAE). There are multiple treatment options for breast cancer including surgery, radiotherapy, and chemotherapy. Nevertheless, these treatments often impact surrounding tissues and cause side effects. Consequently, researchers seek an alternative approach that offers high efficacy and reduced cytotoxicity. Medicinal plants serve as a promising alternative for cancer treatment due to their accessibility, efficacy, and lower toxicity. Haplophyllum tuberculatum is …

Increasing The Phytoremediation Efficiency Of Heavy Metal-Contaminated Soils In The Uae Using Endophytic Actinobacteria For Sustainable Agriculture, Archana Mathew Mathai

Theses

Pollution caused by heavy metals (HMs) is a major environmental concern worldwide. Human actions, agriculture practices and industrial activities can cause the release of HMs into the environment. Soil contamination with HMs may have negative effects on crops, thus disrupting the food chain and posing risks to human health. Lead (Pb) is a common pollutant found in the soil when at high concentrations. Conventional land remediation techniques depending on chemical and mechanical methods are quite expensive and would lead to long-term deterioration of the ecosystems, while phytoremediation can serve as an alternative, eco-friendly approach to restore the lands for agricultural …

Teachers’ Perceptions Of The Implementation Of The United Arab Emirates Teacher Licensing System In Private Schools In The Abu Dhabi Emirate, Honey Ousama Al Bahri

Theses

The Teacher Licensing System (TLS) is a significant initiative in education in the United Arab Emirates (UAE), designed to regulate, control, and ensure the professionalism and competence of educators. Established by the Ministry of Education (MOE), its primary objective is to uphold high-quality education and safeguard students' interests. Following a quantitative method, the study aims to explore the perceptions of the teachers who completed the TLS regarding the Specialization and the Pedagogy tests, and the added value of the test, in addition to investigating the impact of the teachers’ demographics on their perceptions. Data were collected via a questionnaire and …

Expression Of Human Arginine Vasopressin In Arabidopsis Thaliana And Assessment Of Abiotic Stress Tolerance, Maitha Salem Aldarmaki

Theses

Human Arginine Vasopressin (HsAVP) is a nona-peptide that acts as an antidiuretic hormone. In human AVP regulates water permeability through the regulation of the water channel, aquaporin 2. The process begins with the binding of vasopressin to V2 receptor which activates cAMP-dependent protein kinase A (PKA). PKA phosphorylates aquaporin-2 at Ser256 and allows the aquaporin-2-containing vesicle to fuse with the apical membrane which increases water permeability. The present study describes the functional analysis of the codon-optimized HsAVP overexpressed in Arabidopsis thaliana. The main objective of the study is to assess if HsAVP affects drought and salinity stress …

Investigating The Magnetic Cycle Of The Planet-Hosting Star Hd189733, Mohammad Samih Raja

Theses

HD189733 is a planet-hosting star, harboring a hot Jupiter situated at approximately 8.8 stellar radii. This system is among the most studied systems for stellar magnetism, Star-Planet Interactions, and exoplanetary atmospheric studies. The largescale magnetic field of the star exhibits variability on relatively short timescales, however, no magnetic field cycle, including polarity flips, has been observed to date. This absence of cycle detection could be due to observational gaps between observing campaigns.

This thesis aims to explore the variability of the activity of HD189733 by conducting a homogeneous analysis of several publicly available datasets, obtained using several spectrographs/telescopes, spanning 18 …

ﺣﻖ اﻟﻤﺴﺘﮭﻠﻚ ﻓﻲ اﻟﻌﺪول ﻋﻦ اﻟﻌﻘﺪ اﻹﻟﻜﺘﺮوﻧﻲ ( دراﺳﺔ ﻣﻘﺎرﻧﺔ ), بدور صالح الكثيري

Theses

Consumer's right to withdraw from the electronic contract

A Comparative Study

Technological development has significantly changed how people communicate, particularly in concluding contracts. Sales contracts, often executed through modern communication methods and the internet, have become especially common due to their speed. This convenience often leads consumers to accept contracts hastily, relying only on photographs and descriptions provided by sellers. These descriptions may be inaccurate, or consumers may be misled by false advertisements, as these contracts are made remotely without physical interaction.

The consumer, a vital part of the economic process, increasingly faces assaults on their rights, particularly in electronically …

Prevalence And Risk Factors Of Hikikomori In Young Adults In The Middle East, Harshil Paresh Shah

Theses

Hikikomori, a form of severe social withdrawal that can occur without the presence of any other psychological disorder, was once thought to be a Japanese culture-bound phenomena. However, studies have emerged from several parts of the world showing that this may be a global issue. Extant literature suggests associations between hikikomori and behavioral addictions such as gaming addiction and Problematic Social Media Use (PSMU). Since there is a relative paucity of research examining this phenomenon in the Middle Eastern context, this study aimed to determine the prevalence and risk factors of hikikomori in young adults of the Middle East. It …

مبدأ الاقتناع القضائي في ضوء أحكام المحكمة الاتحادیة العلیا, محمد حسن العیدروس

Theses

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The Principle of Judicial Conviction in View of the Rulings of the Federal Supreme

The principle of judicial conviction is the main pillar of the theory of criminal evidence, it is not imagined that the criminal judge issues his judgment without basing this judgment on a firm conviction that has no doubt or guess, as it is known that criminal judgments of conviction are based on certainty and certainty, and the principle of judicial conviction represents a major guarantee of reassurance of the validity and integrity of penal judgments and access to justice, and this study dealt with rooting …

Molecular Geometry Changes In Some Carbonyls And Aromatic Rings Upon Electronic Excitation: Herzberg-Teller Vibronic Coupling And Unitary Duschinsky Rotation, Maryam Yahya Al-Sakkaf

Theses

The common assumption in probing the dynamical motion of molecules is that the molecular electronic activity depends weakly on vibrational coordinates on electronic excitation. Therefore, electron-vibration interaction, which is known as Vibronic Coupling (VC), may be ignored. The Herzberg-Teller theory of Vibronic Coupling (HTVC) is a breakdown of the Born-Oppenheimer Approximation (BOA) since nuclear and electronic degrees of freedom can no longer be separated. The inclusion of a single quantum of a non-totally symmetric vibrational mode changes the overall symmetry of the state and permits the transition. Often, this assumption may be invalid, especially in carbonyl and aromatic compounds. This …

Evaluating The Impact Of Hybrid Ventilation Strategies On Reducing The Cooling Load And Achieving Thermal Comfort Of Buildings: Regarding Arid Climate Of Uae, Sheikha A Hmed Al Niyadi

Theses

The hybrid ventilation system has shown considerable potential in managing indoor thermal comfort, preserving indoor air quality, and minimizing energy usage. This is achieved by integrating natural and mechanical ventilation. When natural ventilation is unfeasible, the system smoothly transitions to mechanical ventilation to uphold optimal indoor thermal comfort levels. However, the application of this system in extremely arid regions poses a challenge due to the high energy consumption linked to air conditioning and cooling during the summer. In these areas, air conditioning and cooling alone represent approximately 60% of urban energy consumption. This study aims to assess the viability of …

Disturbance Observer-Based Control For Pmsg-Based Wind Turbiner Considering Unbalanced Grid Conditions, Moayad Alanani Maher

Theses

A typical Permanent Magnet Synchronous Generator (PMSG)-based wind turbine system consists of an electrical generator, Machine-Side Converter (MSC), Grid-Side Converter (GSC), dc-link capacitor, and a passive filter such as L filter or LCL filter to connect the GSC to the host grid. When the wind turbine operates under unbalanced grid voltages, a negative sequence component is introduced to the system. This negative sequence voltage can pose challenges for classical controllers to ensure an efficient control of the PMSG-based wind turbine system. On one hand, when the control objective is to ensure injecting sinusoidal and balanced three-phase currents to the grid, …

Theoretical And Computational Astrochemistry: A Variational Quantum Monte Carlo (Vqmc) Study Of The Trihydrogen Molecule Cation (H3+), Ahmad Saeed Alsaed

Theses

H₃⁺ is the simplest Three-Center Two-Electron molecule and it is of much interest in astrochemistry due to its high occurrence in the outer space, high reactivity, and strong acidic properties. In addition,H₃⁺ is involved in many chemical reactions in the interstellar medium (ISM) and its significant ability to absorb energy contributed to the cooling of the Universe during its early stages.

The main objective of this thesis is to approximate the ground state electronic energy of H₃⁺ by using a simple trial wavefunction consisting of a doubly occupied molecular orbital multiplied by a Jastrow …

اﺳﺘﻌﻤﺎل اﻟﻌﻘﻮد اﻟﺬﻛﯿﺔ ﻓﻲ ﺳﻮق اﻷوراق اﻟﻤﺎﻟﯿﺔ: دراﺳﺔ تحليلية, ﻣﺤﻤﺪ ﺧﺎﻟﺪ إﺑﺮاھﯿﻢ

Theses

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Using Smart Contracts in Financial Stock Market: An Analytical Study

Smart contracts are considered one of the latest technologies that have obtained attention from many Legalists and Engineers. Smart contracts are a set of arrangements written via programming languages through computer programs or by programmers without the need for an intermediary. Smart contracts are self-executing. It executes once the terms and conditions agreed between the parties happen.

Perspectives differ among legalists about the legality of smart contracts. Some legalists consider these contracts as binding legal contracts, while others believe that a smart contract might be just a part of …

اﻻﺧﺘﺼﺎص اﻟﻨﻮﻋﻲ ﻟﻤﺤﻜﻤﺘﻲ اﻟﺠﻨﺎﯾﺎت اﻟﻜﺒﺮى واﻟﺼﻐﺮى طﺒﻘﺎ ﻟﻘﺎﻧﻮن اﻹﺟﺮاءات اﻟﺠﺰاﺋﯿﺔ اﻻﺗﺤﺎدي, ﺧﺎﻟﺪ ﻧﺪﯾﻠﮫ اﻟﻨﻌﯿﻤﻲ

Theses

The Specific Jurisdiction of the Major and Minor Criminal Courts in Accordance with the Federal Criminal Procedure Law

This study deals with the rules of specific jurisdiction for the major and minor criminal courts in accordance with the Federal Code of Criminal Procedure, where specific jurisdiction is one of the most important jurisdictions stipulated by the federal legislator, by allocating specific courts to specific types of crimes. In light of this, the federal legislator in the United Arab Emirates has singled out a new system with regard to specific jurisdiction, distinguishing between the major and minor criminal courts in terms …

Optimization Of In-Vitro Regeneration And Agrobacterium-Mediated Transformation Of Lactuca Sativa, Mohamed Omer Elsiddig

Theses

Lettuce (Lactuca sativa L.) is a leafy vegetable consumed worldwide, mainly as a green salad. It is an herbaceous, self-pollinated annual plant of the family Asteraceae. Lettuce is low in calories, fat, and sodium. It is a good source of fiber, iron, folate, and vitamin C. Improving existing lettuce varieties for water use efficiency, photosynthesis efficiency, salt tolerance, increased nutritional content, etc., is the need of the hour, considering that lettuce is a crop ideal for vertical farming in the UAE.

This study aimed to develop a highly efficient in vitro regeneration and Agrobacterium- mediated transformation protocol for a popular …

Faithful Representation Of Free Groups And Congruent Subgroups Of Sl3(Z), Julius Kurian

Theses

This thesis is concerned with the matrix representation of a free nonabelian group by matrices of size ≥ 3. We proceed from defining an equivalence class and then transitioning to free groups.We discuss in details the group G_n(k) which is the group generated by the matrices filled with first, (second, etc.) column, except for the intersection with the diagonal, and we have ones on the diagonal and zeros at the other places. The filled places are occupied by the same parameter k. An alternative proof for the known fact that G_n(3) is not …

Pricing Asian Options During Crises With The Impact Of Exogenous Event, Moath Ali Bakour

Theses

Asian options are financial derivatives products whose value depends on the value of underlying asset prices. These options are called path-dependent since their payoff is built on the prices of the underlying asset over some time. As in the case of the European options, the Asian option pricing problem is primarily subject to the prediction model for asset prices. The pioneer Black-Scholes model in the paper [2] suggests a GBM-Geometric Brownian motion. The Black-Scholes formula has several shortcomings. For instance, the Geometric Brownian motion does not take into consideration crises. Another problem in the Black- Scholes model is that it …

Perspectives Of Special Education Teachers On The Transition Of Students With Special Needs From High School To University, Noor Abdulkader Mamich

Theses

Post-secondary transition is a significant phase in the life of high school students with special needs. Special education teachers play a crucial role in supporting students in this process. This study aims at exploring the perspectives of special education teachers on transitioning high school students with special needs into university. Semi-structured interviews were conducted with four special education teachers in Al Ain city in the United Arab Emirates. The teachers were asked questions on four themes: their skills on postsecondary transition, their post-secondary transition planning, the barriers they face during post-secondary transition, and finally the facilitation of smooth post-secondary transition …

Unveiling The Origins Of Source Code Through Authorship Attribution: A Comparative Study Of Ai And Human Coding Patterns, Shamma Humaid Alalawi

Theses

In recent years, Artificial Intelligence (AI) techniques have been used for source code authorship attribution, which is the process of identifying the original author of a given piece of code. With the advancement of AI technologies like ChatGPT, which can generate code, there is a need to accurately identify whether a piece of code is written by a human or generated by a machine. This is crucial for intellectual property protection, cybersecurity, and software forensics. The main objective of this thesis is to review existing research on source code authorship attribution and conduct several experiments to determine the best AI …

Improving Early Design Processes With The Use Of Bim And Vr Technologies In The Gcc Construction Industry, Mohamed Wahid Mohamed

Theses

The early stages of construction projects play a crucial role in determining the outcome of the entire project life cycle. However, conventional early design practices have been facing significant challenges and limitations in recent times. These challenges include a lack of coordination among various disciplines, communication gaps, and poor decision-making. Unfortunately, these challenges often lead to increased costs, project delays, and change orders. To tackle these challenges, it is essential to adopt the latest technological advancements in the construction industry. This is especially important given the complexity of modern construction projects and the rapid construction growth. One of the most …

Synthesis And Biological Assessment Of Safranal-Loaded Metal-Organic Framework Nanostructures, Alia Musabbeh Alkaabi

Theses

Liver cancer remains a primary worldwide health concern, necessitating the development of innovative and effective treatment options. In this study, we present a biocompatible iron-based metal-organic framework (Fe-MOF) consisting of iron ligands connected by terephthalate linkers loaded with safranal, a major biomolecule of saffron (the stigmas of Crocus sativus flower), as therapeutic intervention with dual efficiency. This compound not only meets the demand for improved liver cancer therapies but also exhibits antibacterial properties against Escherichia coli and Lactobacillus. The synthesis stage of the study focuses on preparing MIL-88B(Fe) and loading safranal into/onto its structure (SAF@MIL-88B(Fe)). The material's composition and …

Mapping And Analyzing Urban Growth In The Abu Dhabi Metropolitan Using Geospatial Technologies Integrated With Machine Learning, Hamsa Mohamed Yusuf

Theses

Urbanization is happening at a rate twice the increase in population on a worldwide scale. This has great environmental and social impacts, along with large impacts on regional climate and one of the reasons for this is the ever-continuous change of land use and land cover. The availability of high-resolution satellite imagery in addition to the advancements in geospatial technology allow mapping of LULC changes to be done accurately, efficiently and covering wide areas. This thesis studies the urban Land Use and Land Cover Change (LULCC) that happened in Abu Dhabi city for the last 3 decades by utilizing geospatial …

“Art For The Millions:” The Evolution Of Informal Learning From The Charleston Museum To The New Deal, Kristen Walker

Theses

The advent of the first museum in the United States in 1773, The Charleston Museum, sparked a shift in the way education is perceived and how it can be conducted. However, only recently has the intentional implementation of programs and exhibitions been created in a digestible way for the public. This thesis discusses how informal learning has evolved since the establishment of the Charleston Museum and the legacy of the Federal Art Project regarding informal learning and art education. Key research methods include the examination of primary and secondary resources, including oral histories held by the Smithsonian Archives of American …

There’S Always Room For Improvement: Implementing Indoor Navigation Using ‘Mappedin’ In The Rochester Museum And Science Center To Enhance The Visitor Experience, Izzy Moyer

Theses

Since March 2020, museums have dramatically increased their use of technology in museums to make their environments more engaging to their visitors. For indoor navigation, for instance, museums have used still images, PDFs, and QR codes as well as analog measures (such as directional signage and paper maps) to help their visitors navigate their institution. While these are helpful for understanding one’s general location, other digital wayfinding measures can foster information sharing as well as the opportunity to decrease “spatial anxiety.” This thesis describes the creation of a map for portable, indoor navigation using “Mappedin,” a cost-effective platform that is …

From Ordinary To Extraordinary: Using Storytelling To Reveal The Hidden Histories Of Objects And Enhance Meaning Making In A Living History Village, Jill Poppenheimer Johnson

Theses

Objects without a narrative are simply things. By contrast, an object with a story can be used as a vehicle for a museum to open dialogues with visitors about the people of that time period, how they lived their lives, and what social aspects influenced them. The story of an object, what makes it different from hundreds of others just like it, can change it from ordinary to extraordinary and be used as a powerful learning tool by helping the audience to create connections and make meaning of what they are seeing and experiencing. This thesis explores the relationships between …

Leveraging Sentiment Analysis For Tokyo Airbnb Hosts And Decision Makers, Shaikha Aldahmani

Theses

This study focused on the growing challenges that Tokyo Airbnb hosts and policymakers face in the holiday homes and home stays market. The study aimed to empower hosts with insights to optimize offerings and assist policymakers in informed decision-making for enhancing neighborhood experiences, with a focus on data-driven business strategies grounded in sentiment analysis. The project employed a robust methodology that leverages sentiment analysis techniques to gain insights from guest comments of Tokyo Airbnb listings spanning from September 2011 to June 2023. The CART algorithm and the Affin sentiment lexicon were used for data cleaning, consolidation, and sentiment analysis. The …