Digital Commons Network^™

Targeting Rna Polymerase I In Ewing Sarcoma Treatment, Alexis Bruce

Theses

Ewing sarcoma is a rare and aggressive pediatric bone cancer with poor survival rates in patients, as low as 30% in advanced or recurrent cases. There are limited treatment options, making molecularly targeted therapy vital to explore. Through CRISPR scans of Ewing sarcoma cell lines, ribosome biogenesis was highlighted as a potential target. As RNA polymerase I is a key component of ribosome biogenesis, the cytotoxic ability of two RNA Polymerase I inhibitors, CX-5461 and BMH-21, were used on patient-derived Ewing sarcoma cells. The efficacy of the drugs on two cell lines was determined via measuring cell viability, migration potential, …

Hidden Diversity In A Clonal Endemic: Insights Into Clematis Socialis From A Population Genetics Perspective, Joanna M. Lapoint

Theses

Clematis socialis (Kral) is a rare, federally endangered perennial species restricted to a small number of fragmented populations in Alabama and Georgia. The species exhibits extensive clonality and limited sexual recruitment, characteristics that complicate expectations regarding genetic diversity and population connectivity. Despite its conservation significance, genome-wide assessments of population structure have been lacking. We used genotyping-by-sequencing (GBS) to generate a genome-wide SNP dataset for 170 individuals sampled from six natural populations. Population structure and genetic differentiation were evaluated using Bayesian clustering, analysis of molecular variance (AMOVA), pairwise FST estimates, and network-based visualization. Analyses revealed strong genetic structuring among populations and …

Cellular And Molecular Characterization Of Ube3a Function In Cic-Dux4 Sarcoma, Jesse D. Walker

Theses

CIC-DUX4 sarcoma (CDS) is a rare and extremely aggressive soft tissue sarcoma that primarily affects children and young adults. CDS is characterized by an oncogenic chromosomal translocation. Current treatments for CDS are similar to those in other sarcomas like surgery, chemotherapy, and radiation. Treatments, however show that CDS responds poorly compared to other sarcomas, due to relapses of localized disease at high rates and short duration response of treatment, proving the importance of understanding CIC-DUX4’s complex role on how it regulates overall gene expression in CDS cells from a molecular approach.

UBE3A is a ubiquitin protein ligase that plays a …

Evaluating The Effects Of Behavioral Skills Training On Defensive Back Skills In High School Football Players: A Focus On Man Coverage, Malachi James Jackson-Talmadge

Theses

Behavioral Skills Training (BST) is an intervention package that involves instructions, modeling, rehearsal, and feedback. BST has been used to enhance athletic performance in several sports (e.g., soccer, field hockey, bowling). In football, two prior studies have shown improved football-specific skills following BST. Although effective, both studies implemented BST individually with each player, which can be time-consuming during football practices. Providing BST to groups of players may be an efficient alternative. Currently, no study has evaluated the effects of group BST in sports. The current research used a multiple baseline design to evaluate the effects of group BST on man …

The Indian River Lagoon Through The Lens Of An Artist: Examining The Impact Of Growth And Development On The Lagoon's Water Quality, Lisa K. Skelly

Theses

This project investigates the ecological degradation of the Indian River Lagoon, a vital estuary on central Florida’s east coast. The research focuses on the intersection of habitat loss and water quality degradation, specifically as they relate to anthropogenic factors such as land development and nutrient pollution. Furthermore, the study evaluates the effectiveness of environmental art in fostering environmentally conscious behavior. I translated these findings into a cohesive body of work, including ceramics, fiber arts, and oil painting, utilizing site-specific materials sourced from the lagoon. By integrating these organic elements, the work aims to showcase the estuary’s natural beauty while highlighting …

Testing The Intermediate Disturbance Hypothesis On Anthropogenic Pressure In Central Alabama, Gavin Terrell

Theses

Biodiversity is fundamental to maintaining ecosystem structure and function globally. Prior to the late 20th century, ecological theory generally predicted that biodiversity would be highest in systems experiencing minimal disturbance. However, Joseph H. Connell challenged this view with the Intermediate Disturbance Hypothesis (IDH), which posits that species diversity peaks at intermediate levels of disturbance and declines under conditions of both low and high disturbance. Although widely cited, the applicability of the IDH to natural systems remains debated, particularly in the context of anthropogenic disturbances and when diversity is measured beyond species richness alone.

This study evaluated the predictions of the …

Branding Through Semiotics, Minimalism, & Branding Psychology: The Eurekafit Brand, Torri Salem

Theses

This paper examines how the combination of minimalism, semiotics, and branding psychology work seamlessly together to create an inclusive brand with an emotionally resonate visual identity system-- a brand that is cohesive and bridges the sub-brands of EurekaFit and Eureka CrossFit. What initially started as a logo redesign of Eureka CrossFit has now expanded into this dual-branding visual system, that communicates approachability, a sense of belonging and fitness, without being intimated, to its audience. This study investigates visual signifiers like color, typography and imagery, through a semiotic analysis and approach. I reduced clutter and visual noise and was able to …

Petals Of The Mind: A Digital Floral Interpretation Of Mental States, Corine D. Arrington

Theses

Petals of the Mind is an applied studio art project that explores the use of symbolic floral imagery to visually represent internal emotional states, specifically depression, anxiety, and ADHD. This project consists of six large format digital posters created in Procreate. Each emotional category is represented by a pair of flowers selected for their symbolic and structural characteristics: Blue Poppy and Black Rose for depression, Tulip and Aster for anxiety, and Honeysuckle and Wildflower Mix for ADHD. These flowers are intentionally deconstructed through layering, fragmentation, and motion cues to mirror common internal experiences such as emotional heaviness, vigilance, cognitive scattering, …

Beyond The Nude: Reimagining Feminist Agency In The Art Of Suzanne Valadon, Sofia Harris

Theses

This thesis examines the work of Suzanne Valadon (1865–1938) through a feminist art historical lens, challenging long-standing interpretations of her female nudes as inherently resistant to the conventions of Western art. Structured as a three-part lecture series, the project situates Valadon within a visual tradition in which women have been overwhelmingly represented by men, arguing that her engagement with the nude remains embedded in the same systems of objectification it is often said to subvert. Lecture One establishes the historical framework by tracing enduring archetypes of femininity, demonstrating how representations of women have functioned as projections of gendered power. Lecture …

Alabama Prairie Reconstruction: Comparing Management Pathways For A Southeastern Landscape, Cecelia R. Geyer

Theses

Southeastern prairies are highly biodiverse yet increasingly threatened by land-use change, fire suppression, and habitat fragmentation. These disturbance-dependent systems rely on periodic fire and grazing to maintain plant diversity and ecosystem function. This study evaluates prairie restoration strategies by testing predictions from the Intermediate Disturbance Hypothesis and the Patch Mosaic Burn Hypothesis. The study site was divided into three treatments: prescribed burned only (B), prescribed burned with mowing (BM) to simulate grazing, and an undisturbed control (C). A standardized mix of native plant seeds was broadcast across all treatments. Ecosystem health and function were evaluated using plant community diversity and …

Emote - A Modular Action Figure For Childhood Emotional Growth, Terrence Li

Theses

Emotional regulation and communication are one of the most important skills that we can learn. This skill allows us not only to recognize and effectively communicate our feelings to others but also allows us to recognize them in others. Although learning and recognizing these emotions may be a pursuit in which progress varies from person to person, this skill is especially invaluable to young children. Beginning as early as the age of 3, many children begin to show early awareness of their own emotions, such as reacting to discomfort or comfort, or starting to use words for feelings. This learning …

Under The Surface: A Scalable Experiential Framework For Accessible Design Archives, Lo Fasano

Theses

Preserving design history is usually done by hiding it away. While institutions like the Vignelli Center for Design Studies house over 750,000 artifacts, the vast majority remain in restricted storage, with minimal space dedicated to displaying process materials alongside canonical final works. Digital archives document portions of these collections, but typically present them as static image galleries, leaving the evolutionary logic of a design, and the human labor behind it, invisible to the public. Under the Surface is a scalable, interactive framework designed to bridge archival preservation and public discovery. By transforming preserved artifacts into real-time digital experiences, the project …

Adapting Specpt For Hst Grism Spectroscopy Via Transfer Learning, Clive Kalathoor Binu

Theses

This thesis demonstrates the successful application of transfer learning to bridge ground-based and space-based spectroscopic analysis through adapting SpecPT (Spectroscopy Pre-trained Transformer) for Hubble Space Telescope WFC3 grism data for redshift prediction. Originally trained on high-resolution DESI spectra, SpecPT initially failed when applied directly to low-resolution, noisy HST WFC3 grism observations (Normalized Median Absolute Deviation (NMAD) = 0.2095, catastrophic outlier fraction ($\eta$) = 47.97\%). Through transfer learning on 8,530 high-quality 3D-HST spectra with emission-line SNR > 2.5 and z < 1.7, the model achieved substantial improvement (NMAD = 0.0724, $\eta$ = 26.69\%), representing a 65\% reduction in typical redshift error and 46\% decrease in catastrophic failures. The research addresses two primary objectives: establishing transfer learning effectiveness for cross-domain spectroscopic analysis and investigating whether supplementing grism spectra with broadband photometric data enhances performance. Counterintuitively, integrating comprehensive multi-wavelength photometric data from CANDELS significantly degraded performance (NMAD = 0.1641, $\eta$ = 36.51\%), challenging conventional astronomical assumptions about multi-modal data fusion and revealing critical failure modes in astronomical machine learning. This work establishes a unified framework for automated analysis of both ground-based and space-based spectroscopic surveys, with important implications for JWST, Euclid, and the Nancy Grace Roman Space Telescope. The demonstrated capability to adapt models across instrumental domains provides a scalable approach for processing large data volumes from next-generation missions, validating foundational model approaches that can be developed once and efficiently adapted across diverse observational contexts.

In-Context Retrieval For Molecules And Chemical Synthesis Pathways, Abhisek Dey

Theses

Contrastive learning methods require well-defined positive pairs, limiting their applicability to domains where complete, high-fidelity pairings are available. In practice, large-scale scientific corpora --including patents, publications, and web-scale data -- contain vast quantities of contextually relevant but incompletely paired samples that are discarded under standard training paradigms. In this work, we demonstrate that hard negative mining can be leveraged to construct pseudo-positive supervision signals from unpaired or partially paired data, enabling contrastive learning to exploit the full breadth of available corpora without sacrificing representational quality. Using a large-scale chemical drug patent corpus as a testbed, we train a cross-modal contrastive …

The Best Practices For Prefabrication Of Industrial Buildings, Derek Gines

Theses

Prefabrication has demonstrated measurable and repeatable advantages in productivity, cost certainty, and environmental performance, yet its adoption within industrial building typologies remains largely inconsistent. Existing research largely evaluates prefabrication through downstream performance outcomes, while offering limited insight into the upstream design and organizational decisions that enable or undermine its reliability. This thesis reframes prefabrication as a design‑led methodology rather than a construction optimization, arguing that successful hybrid prefabrication is determined primarily by early decision timing, governance structures, and the control of spatial and logistical interfaces. This study adopts a qualitative design‑research approach that combines comparative case study analysis with expert …

An Artist’S Playground: Building Bridges Between Children’S Education And Their Knowledge Of Art Through Multi-Modal Learning, Alice J. Cauchi

Theses

Not all museums welcome children as part of their main audience with open arms. Research suggests that experiencing museums as a child supports classroom learning and development, but only when the museums engage young children properly. This paper explores how incorporating multi-modal interactives into art museums can effectively engage children, ages 4 to 8, and build a foundation that supports lifelong learning. Drawing on ideas from early-childhood education, museum visitor-engagement studies, and interactivity sciences, this project results in a framework that guides art museums on how they can overlap play, interactives, and content to incorporate this age group effectively to …

Dissent By Design: Graphic Communication And The Continuity Of Resistance As A Civic Practice In The United States, Ryan "Rain" Milligan

Theses

Graphic communication has played a role in shaping civic life in the United States throughout much of its history, influencing how individuals recognize injustice, understand systems of power, and participate in collective action. Typically associated with moments of protest or political upheaval, printed materials such as pamphlets, broadsides, newspapers, and posters have also functioned as everyday tools that structure public engagement. This project examines these materials through the framework of agitation, education, and organization, considering how graphic communication operates across different historical contexts to provoke recognition, make complex ideas accessible, and coordinate collective effort. Drawing from a range of historical …

Traditional And Machine-Learning Equalization Techniques For Bandwidth-Limited Short-Reach Optical Communication Channels, Abdullah Khawatmi

Theses

This thesis investigates equalization techniques for bandwidth-limited short-reach optical communication systems, with a focus on Visible Light Communication (VLC) and Step-Index Plastic Optical Fiber (SI-POF) links. Commercial light-emitting diodes and photodiode receivers impose severe bandwidth constraints, inter-symbol interference, and noise sensitivity, which fundamentally limit achievable data rates. The work addresses these impairments through systematic evaluation of traditional digital signal processing–based equalizers and modern machine-learning-based post-equalization methods. The primary aim of this thesis is to enhance the achievable data rate and reliability of commercial short-reach optical links while maintaining practical computational complexity. Specifically, the objectives are to (i) design and experimentally …

Transport Of Quantum Walks In Electric Fields, Yousef Mohammad Yousef Salah

Theses

This thesis presents an analysis of transport in one-dimensional discrete-time quantum walks (DTQWs) on the Hilbert space ℓ²(ℤ) ⊗ ℂ². Quantum walks serve as fundamental models of coherent quantum transport and exhibit ballistic spreading driven by superposition and interference. The primary focus of this work is the review and derivation of sharp maximal velocity bounds for several classes of quantum walk step operators, including the shift-coin walk, the split-step walk, and models with constant as well as position-dependent coin operators. We establish general a priori bounds that remain valid beyond the translation-invariant regime. For homogeneous models, Fourier and spectral analysis …

Development Of A Novel Cfd Approach For Predicting Multiphase Flow Enhanced By Machine Learning, Abdulrahman Elazazi Salem

Theses

Accurate estimation of interface orientation is crucial for ensuring both the accuracy and robustness of Volume of Fluid (VOF) schemes in multiphase flow simulations, especially when using non-uniform Cartesian meshes. Conventional gradient reconstruction approaches, such as least-squares (LSQ) methods, often suffer from significant errors and strong oscillations on highly stretched grids. This work proposes a grid-transferable, learning-based methodology that predicts interface unit normal vectors directly from the local volume-fraction field on nonuniform structured Cartesian grids using a feedforward neural network. The methodology extends earlier work originally developed for uniform grids, which is first reproduced to assess how performance deteriorates in …

جريمة تزوير المستند الالكتروني طبقا للمرسوم بقانون اتحادي رقم (46) لسنة 2021 بشأن المعاملات الإلكترونية وخدمات الثقة, كلثم راشد المزروعي

Theses

The Crime of Electronic Document Forgery under UAE Legislation: A Legal and Judicial Analysis in Light of Digital Transformation

This study examines the crime of electronic document forgery in light of rapid digital transformation and the challenges it poses to legal systems, particularly in the United Arab Emirates. The research problem lies in the absence of a comprehensive legal framework, the difficulty of classifying technologically evolving forms of forgery, and the challenges associated with proving such crimes using digital evidence.

The study aims to analyze the legal nature of electronic document forgery, distinguish it from traditional forgery, identify its elements …

Using Deep Learning To Increase Eye-Tracking Robustness, Accuracy, And Precision In Virtual Reality, Kevin Barkevich

Theses

Algorithms for the estimation of gaze direction from mobile and videobased eye trackers typically involve tracking a feature of the eye that moves through the eye camera image in a way that covaries with the shifting gaze direction, such as the center or boundaries of the pupil. Tracking these features using traditional computer vision techniques can be difficult due to partial occlusion and environmental reflections. Although recent efforts to use machine learning (ML) for pupil tracking have demonstrated superior results when evaluated using standard measures of segmentation performance, little is known of how these networks may affect the quality of …

Medical Detection Dogs: A Visual Exploration Of Canine Olfactory Anatomy & Volatile Organic Compounds As Applied To Non-Invasive Biomedical Detection, Kirsten Santiago

Theses

Medical detection dogs provide a non-invasive early method of disease and medical alert detection that is underrepresented in the medical visualization sector. The domesticated dog, or Canis familiaris, is known for its loving nature and has become an important member of many households, but they are also incredibly intelligent with a capacity for specialized training. Dogs have a specialized olfactory system, allowing them to detect scents with high acuity (Guest & Otto, 20). Volatile organic compounds or VOCs are molecular substances associated with metabolic processes that are often a result or byproduct of certain diseases and can be influenced by …

Horizontal Gene Transfer In Neisseria, Wen Ting Dong

Theses

Antibiotics are a special category of drugs that help treat bacterial infections by killing bacteria or hindering their growth and replication. Antibiotics are greatly significant in modern medical practices, providing an effective treatment for bacterial infections as well as enabling organ transplants, open surgeries, and chemotherapy to be possible. Unfortunately, cases of antibiotic resistance were observed shortly after the introduction of antibiotics. The appearance and spread of these resistant strains poses a significant threat to public health safety. The Centers for Disease Control (CDC) estimates there are 2,868,700 antibiotic-resistant bacterial and fungal infection cases per year in the United States, …

What Do Future Nutrition Professionals Think About Wic Jobs? A Study Of Nutrition Career Perceptions, Madison Degenfelder

Theses

Background: The Special Supplemental Nutrition Program for Women, Infants and Children (WIC) program faces a critical workforce shortage, yet little is known about the knowledge, attitudes, and beliefs of nutrition students and recent graduates regarding WIC career pathways, requirements, and compensation. Understanding these factors is essential to design strategies to strengthen recruitment and build a sustainable WIC workforce. Objective: To identify and describe knowledge, attitudes and beliefs on entering the WIC workforce among college nutrition and dietetics students and recent graduates. Design: A mixed-methods, sequential study design which included a cross-sectional survey and two focus groups was employed to ascertain …

The Gospel Of Glamour: A Christian Woman's Style Blueprint, Osaromwenyeke Osemwota

Theses

The Gospel of Glamour: The Christian Woman’s Style Blueprint was a luxury-branded, sustainability-focused, faith-based style guide that addressed a gap in fashion, theology, and sustainability scholarship. Existing literature had either systematized fashion, explored the spiritual significance of dress, or examined sustainable and luxury practices—but none had integrated these dimensions into a prescriptive, actionable guide for Christian women. Drawing on Scripture as the foundational authority, including passages from Genesis, Exodus, Psalms, and Proverbs, the guide framed clothing as both practical provision and visible expression of covenantal identity. The style guide synthesized secular fashion methodology, modest-fashion scholarship, and sustainable luxury principles to …

The Disney Adult: A Consumer That Creates Free Marketing, Emily Elizabeth Kempf

Theses

This research looks at the evolving complex relationship between the Walt Disney Company, The Disney Adult content creators and the fan base. It focuses on how user-generated content (UGC) and social media can play a large role in contemporary marketing strategies. As the target audience has expanded to include Disney Adult, this new audience has become a central part in the company’s marketing strategy encouraging fan engagement across all social media platforms. This research is a qualitative case study on the Disney Adult and how social media content can be used as a core marketing strategy. The Disney Adult influencer …

Artemisia Gentileschi's Judith And Her Maidservant Serves As A Message Of Hope, Holly Kyseth

Theses

This thesis argues that through iconography and specific artistic techniques, Artemisia Gentileschi’s Judith and Her Maidservant utilizes the biblical story of Judith and Holofernes to relay a distinctly female-centered narrative, reflective of the ideals of her seventeenth century Italian community. This piece stands apart from other representations of this narrative in that Judith was commonly shown as either dainty yet violent in the act of decapitating Holofernes, or as a saintly victor proudly displaying his head to her people. With Judith and Her Maidservant, Artemisia displays an obvious sororal alliance between Judith and her servant Abra, while cleverly implementing Caravaggesque …

Mediators Of The Dead: Funerary Strategies And Material Practice In The Final Jōmon Period, Celeste Marie Tran

Theses

Shakōki-dogū are prehistoric clay figurines from Japan’s Final Jōmon period, characterized by enlarged, goggle-eyed features. In both scholarship writing and museum display texts, generalized thematic labels or iconographic readings sometimes reduce the corpus’s internal variability. This study examines a focused set of Final Jōmon shakōki-dogū from northern Honshū (Tōhoku) and Hokkaidō (Figures 2–6) through their formal and material evidence—shape, surface treatment, and condition—read alongside published excavation reports and catalogue records. It asks what these figurines can be shown to do, as prehistoric artworks, within death-related practice when interpretation is anchored to observable features and documented context, rather than to a …

Art Therapy In The Art Classroom, Sherry Williams

Theses

The integration of art therapy practices within the art classroom provides a transformative framework for supporting the emotional and psychological well-being of students. Research into these strategies demonstrates that creative practices allow students to manage stress and anxiety while fostering mindfulness, reflection, and self-expression. Art educators can create safe and supportive environments by incorporating therapeutic activities such as drawing mandalas, doodling, and engaging in collaborative projects. These methods prioritize the creative process over technical achievement, allowing students to communicate complex feelings that may be difficult to articulate verbally. 

While art teachers are not licensed therapists, they can effectively implement therapeutic …