Digital Commons Network^™

An Evaluation Of The Use Of Technical Conservation Measures Within The Inshore Mixed Fishery Of Dingle Bay, Co. Kerry, Ireland., Tony Holmes

Theses

Discarding has been identified as a global problem in fisheries. ICES, the EU and national governments have prioritised studying discarding as an area of research. In conjunction with Bord Iascaigh Mhara (BIM), the Marine Institute, Institute of Technology, Tralee and the Dingle Bay Inshore Management Development committee a study of the impacts of incorporating technical conservation measures (TCM’s) into trawls was undertaken. TCM’s under investigation included 80mm and 90mm square mesh panels inserted in the top-sheet before the cod-end, 100mm codends and a separator trawl. It was found that boats using 100mm cod-ends produced less discards than when towing standard …

Mathematical Modeling And Simulation Of Human Motion Using 3-Dimensional, Multi-Segment Coupled Pendulum System : Derivation Of A Generalized Formula For Equations Of Motion, Loay Ahmed-Wasfe Al-Zube

Theses

The use of mathematical models to investigate the dynamics of human movement relies on two approaches: forward dynamics and inverse dynamics. In this investigation a new modeling approach called the Boundary Method is outlined. This method addresses some of the disadvantages of both the forward and the inverse approach. The method yields as output both a set of potential movement solutions to a given motor task and the net muscular impulses required to produce those movements. The input to the boundary method is a finite and adjustable number of critical target body configurations. In each phase of the motion that …

Mathematical Modeling Of Transient State Transdermal Drug Delivery, Alison Nickol Weltner

Theses

In this work, a two-pathway mathematical model for transdermal drug delivery with iontophoresis is presented. The partial differential equations are described and then solved. An alternative, two-pathway, three-layer model is also presented, and the implications of the coefficients within the equation are discussed. Using Franz cell iontophoretic delivery data from three drug substances (amitriptyline HCl, clomipramine HCl, and nortriptyline HCl), the two-pathway model is regressed to determine the diffusion coefficient and the concentration within the skin at the drug reservoir interface. ANOVA analysis indicates a correlation between iontophoretic current and concentration of drug within the stratum corneum.

Measurement Of The Effectiveness Of Enhanced External Counterpulsation On Heart Rate Variability For Patients With Myocardial Ischemia, Kripa Jayaraman

Theses

This thesis is a study to measure the changes in heart rate variability due to the activity of the autonomic nervous system caused by the Enhanced External Counterpulsation treatment. The treatment is a non surgical, mechanical procedure that can reduce the symptoms of angina or Congestive Heart Failure, presumably by stimulating the opening, or formation of, small branches of blood vessels (collaterals) to create a natural bypass around narrowed or blocked arteries. It has been proved that rhythms can be markers of normal functional states. Even in the absence of external perturbations, the normal heartbeat is not characterized by clockwise …

Case Studies In Disassembly Process Planning, Riteshkumar Dhimmar

Theses

The rapid advancement in technology started in last century and still continuing resulted in decreased life cycle of electronic products. It also resulted in increased product disposal rate and filling land fill space faster causing shortage of such space and consequently creates major environmental problems. So, since couple of decade environmental concern has focused on production process and environmental regulations imposed by government has watched industrial pollution. With government regulations to control environmental problems; consumers are also aware of adverse effects of product disposal forcing manufacturer to become more responsible for safe product disposal and recycling of used product.

A …

An In Vitro Evaluation Of Tyrosine Derived Polyarylates And Polycarbonate As Polymeric Scaffold For Human Mesenchymal Stem Cells Osteogenic Differentiation, Manish Suresh Godbole

Theses

Human mesenchymal stem cells (hMSCs) obtained from the adult bone marrow are multipotential cells that are capable of differentiating along several lineages. They are readily available and abundant source of cells in the field of tissue engineering. For their use in treating certain connective tissue defect or disorders, their success depends at minimum on the use of scaffolds that support differentiation. Therefore , this thesis details a study that systematically evaluated hMSC differentiation on materials that exhibit gradual range in surface properties as a first study for selecting materials as potential scaffolds. Polycarbonates and polyarylates have combinatorial libraries that exhibit …

Osha Laboratory Safety Standard 29 Cfr 1910.1450 And Achieving Compliance In The Microelectronic Laboratory, Danielle M. Digironimo

Theses

This thesis is a practical application of occupational exposures to hazardous substances in a microelectronics laboratory. The Occupational Safety and Health Administration (OSHA) standard for the safety in laboratories is (29 CFR 1910.1450). The application is a demonstration of the implementation of the standard in a university setting. Hazards that exist in laboratory settings are very complex and the task of providing a safe workplace can become increasingly complicated. A laboratory can and does impose different health and safety concerns that a standard industrial workplace setting might not have. The need for a laboratory safety standard program to be implemented …

Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold

Theses

Electrospinning processes apply electric fields to a polymer solution in order to produce strands of polymer in the nanoscale range. These polymer fibers are manipulated for their porosity, high surface area, fineness and uniformity. In order to create the ideal drug delivery system for intracranial arteriovenous malformations (AVMs) and tumors, D, L poly-(lactice-poly-glycolide) (DLPLGA) nanofibers were electrospun in a tetrahydrofuran (THF) solvent. Three different concentration ratios of DLPLGA, 85/15, 80/20, and 75/25 were analyzed to obtain the prime base for drug annexation. 1 ,3-bis (2-chloroethyl)- 1 -nitrosourea (BCNU) was then codissolved with the DLPLGA nanofibers to form a homogenous solution, …

Analysis Of Auf1 Targeted Mrna Sequences, Jiebo Lu

Theses

AUF 1, an A+U rich element (ARE) binding protein, plays an important role in mRNA decay. To identify the mRNAs that interact with AUF 1, mRNA derived from a human cardiac cDNA expression library was purified by AUF 1 affinity chromatography and cloned following RT-PCR. 261 sequences were obtained. The sequences were searched against two protein databases and four nucleic acid databases, and the sequence information and database search results were input into a local Microsoft Access database, BLAST-AUF 1, by Java applets for parsing document. Analysis of protein information by querying BLAST-AUF 1 identified 194 function-known proteins, which were …

Review Of Algorithms For Rna Secondary Structure Prediction With Pseudoknots, Ingrid Helene Nielsen

Theses

Pseudoknots are structures that are formed from the base pairing of an RNA secondary loop structure with a complementary base which lies somewhere outside of the loop. The result is a structure, which plays a vital role in cell structure rigidity, regulation of protein synthesis, and in the structural organization of RNA complexes. Deciphering RNA folding patterns would begin to unravel some of the mysteries surrounding the cell and its functions and open a new world to scientists. Many algorithms have been written in this quest to predict RNA's secondary structure but not many have been very successful.

In this …

Analysis Of Molecular Conformations Using Relative Planes, Deepa S. Pai

Theses

Ring substructures of a drug usually participate actively in binding to the receptor. It is necessary to study the spatial relationship of these molecular recognition features in order to determine the pharmacophore of the drug. This is a particularly difficult problem when the drug is a flexible molecule with many energetically accessible conformations.

In this research an innovative approach to calculate the relative displacement and orientation of every possible pair of rings in a given molecule was designed, tested, and implemented in the "Planes" program. Planes were defined from each of the ring substructures and the displacement and rotation of …

Evaluation Of Effect Of Extrusion Process Variables On Mechanical Properties Of Extruded Collagen Tubes And Effect Of Post Extrusion Treatments, Mayank K. Patel

Theses

This study evaluated the effect of extrusion process variable on mechanical properties of extruded collagen tubes made using a specialized extruder, made by ZOKO Corporation of Czechoslovakia. Three extrusion variables were considered; extrusion speed, linear draw rate and rotation speed. Using Taguchi L₄ matrix, a design of experiment (DOE) was run. Two mechanical properties, wall thickness and estimated elastic modulus, were considered as response of this DOE. Data was analyzed statically to evaluate the effect of extrusion variables on both these properties. Result of this study showed that linear draw rate of the extrusion process has the highest influence …

Fabrication Of Nanofiber Scaffolds By Electrospinning And It's Potential For Tissue Engineering, Shobana Shanmugasundaram

Theses

Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers on to a target substrate. This electrospinning strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to tens of nanometers. This study assesses the potential of electrospinning, as an alternative scaffold fabrication technique for tissue engineering applications. In this study, electrospinning is adapted to produce tissue-engineering scaffolds of two different size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was …

Random Search Conformational Analysis Of Piperazine And Piperadine Analogs Of Gbr12909 : Implicit Aqueous Solvation Effects, William A. Roosma

Theses

The object of this work was to study the effect of solvent on the conformational potential energy surface (PES) of GBR12909 analogs. Local minima on the PES's were found by the Random Search algorithm using the Sybyl molecular modeling package from Tripos, Inc., and an implicit solvent model. Two force-field/charge models were employed in the analysis: the Tripos force field with Gasteiger-Huckel charges and the MMFF94 force field with MMFF94 charges.

The effect of solvent on the location of minima in multi-dimensional torsional angle space was studied by comparison to the vacuum phase results. Minima were plotted in torsional angle …

Particle Size Dependence On Immobilized Molecular Sensors : Assay Of Nucleic Acid Probes Attached To Paramagnetic Particles, Celin Sunny

Theses

Nanotechnology is concerned with materials and systems whose structure and components exhibit novel and significantly improved physical, chemical and biological properties, phenomena and processes due to their nano scale size.

The transition from micro scale to nano scale leads to a number of changes in physical properties, possibly including new physical principles, some of which may be yet to be discovered. One of the major factors in this is the increase in ratio of surface area to volume.

This thesis research uses the increase in ratio of surface area to volume property of going from macro to micro to nano …

Spinning Of Collagen Fibers And Characterizing Thermal, Mechanical, Tensile And Structural Properties, Grace Evangelin Tatagiri

Theses

Collagen is the most important building block in the entire animal world. It plays an important role in regeneration of broken bones and wound healing, also helps grow blood vessels to feed the healing areas. The use of synthetic materials has been extensive, but these materials have there own limits and drawbacks. Poor biocompatibility of these materials is the main issue and often result in inflammations. Hence collagen is being heralded as one of the most appropriate replacement as an implantable material. The reasons being that it is a naturally occurring material, exhibits high biocompatibility low antigenicity and host response. …

Design And Implementation Of Heart Rate Variability Measures In The Time Domain, Binoy John Mathews

Theses

The following study was conducted to design and implement computer programs to derive five time domain and two frequency domain Heart Rate Variability (HRV) measures from 24 hour Holter monitor recordings and to generate activity plots that display the variation of three of the five time domain measures and two frequency domain measures over a period of 24 hours.

Working with known pre and post experimental ECG data taken from a cyclical exercise program, standard parameters in both the time and frequency domains were derived using programs designed in Labview 7.0 engineering software package. Five parameters in the time domain …

Extrusion And Evaluation Of Degradation Rate And Porosity Of Small Diameter Collagen Tubes, Bipinkumar G. Patel

Theses

The limited availability of autografts and failure of small diameter synthetic vascular grafts has stimulated continuing efforts to develop small diameter vascular grafts based on natural materials. The small diameter collagen tubes were extruded using bovine collagen type I. The biodegradation rate was determined and compared for small diameter collagen tubes crosslinked with glutaraldehyde and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and Nhydroxysuccinimide (NHS) to evaluate physio-chemical properties. The samples were also evaluated for their surface area and porosity using mercury porosimeter. The noncrosslinked tubes almost completely degraded after 2 hours. The tubes crosslinked with EDC/NHS degraded slower than the ones crosslinked with …

Biomimetic Sensor For In-Vivo Applications, Daya I. Sooryadas

Theses

The development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic molecule that performs two distinct functions in detecting target molecules. The sensor molecule recognizes a target molecule and specifically binds to it. This specific binding generates a signal in response to the event of target binding that can be then detected. The long term vision of this thesis research work is to develop a specific recognition ligand for detecting …

Processing And Optimization Of Natural Fiber Reinforced Composites Using Date Palm Fibers, Khalifa Musabbeh Suwaidan Hamad Al-Kaabi

Theses

During the last twenty years, ecological concerns have resulted in a renewed interest in natural materials. Composite materials usually depend on using man-made fibers as the reinforcing element. The possibility of using natural fibers instead of synthetic fibers is gaining acceptance among users. This work aims to investigate the possibility of extracting natural fibers from date palm trees to be used as reinforcement with polymeric materials. The objective was achieved by characterizing fibers through different chemical, physical and mechanical tests and using different treatment methods in order to modify the fiber properties. Date Palm Fibers (DPF) exhibit a cylindrical shape …

Bulk Polymerization And Structure-Property Relationship Of Medical Grade Polyurethane, Mariam Nasser Al-Saedi

Theses

Polyurethanes as biomaterials have been used in the augmentation and repair of the human body with great success. The choice of material for a particular application often hinges on the body's response to the polymer, the mechanical and thermal properties of the polymer and the stoichiometric ratio of active ingredients used in the synthesis.

A large number of polyurethanes used in medical applications are polyester-based and cannot be used in long-term implant applications because they are very susceptible to hydrolysis. Other medical-grade polyurethanes, which are suitable for implants are polyether-based which might to some extent, suffer from environmental stress cracking …

Extra-Pair Fertilization, Mate Choice And Genetic Similarity In The Mexican Jay (Aphelocoma Ultramarina), John Andrew Eimes

Theses

Inbreeding depression should select for the ability of females to avoid inbreeding or minimize its effects. We tested for a relationship between genetic similarity of social pairs and the occurrence of extra-pair fertilization (EPF) in the Mexican jay (Aphelocoma ultramarina), a bird species with known inbreeding depression and a high EPF rate (Brown and Brown 1998, Li and Brown 2000). Multi-locus minisatellite and microsatellite DNA fingerprinting were used to detect extra-pair young and measure genetic similarity between social parents. We found that 15 of 38 (39%) nests had at least one EPF and 21 of 115 (18%) young …

A Land Use And Land Cover Accuracy Assessment Based On Landsat 7 Imagery Within The Canandaigua Watershed: Natural Heritage Program And The James Anderson Classification System, Travis Money

Theses

Research that incorporates GIS and remotely sensed imagery has become increasingly popular and important for large-scale environmental applications, such as generating land use and land cover maps. One of the critical aspects of land cover analyses is assigning a land use and land cover classification scheme. This research evaluated two classification schemes, the 2002 Natural Heritage Classification and the 1976 James Anderson System in a land cover analysis of the Canandaigua Lake Watershed using Landsat imagery. It was hypothesized that the Landsat imagery could be used to identify unique ecological communities such as those delineated by the Natural Heritage Classification. …

Establishing A Uae Database Using Str Loci, Ibrahim Abdullah Ali Al-Housani

Theses

The analysis of DNA polymorphism has become an indispensable tool in forensic science and criminal cases. Today, the amplification of Short Tandem Repeat (STR) loci using PCR is the perfect method for typing biological evidence found at crime scenes. Forensic laboratories all over the world have been progressively expanding their databases for better discrimination among individuals and suspects of crimes.

The objective of this thesis was to analyze the DNA profile of native and non-native populations, and to study the similarities and dissimilarities among them. Blood samples were collected from three non-natives (Egyptian, Indian and Pakistani) and native populations from …

Opposite Effects Of Lithium And Valproic Acid On Trophic Deprivation-Induced Gsk-3(Beta) Activation, C-Jun Expression And Neuronal Cell Death, Ning Jin

Theses

Recent studies demonstrate that lithium and valproic acid (VPA), two commonly used mood-stabilizing drugs, have neuroprotective effects against a variety of insults. Inhibition of the pro-apoptotic enzyme, glycogen synthase kinase-3P (GSK-3P), was suggested to be the mechanism of action of neuroprotection for both drugs. In this study, we tested if lithium and VPA could protect cultured cerebellar granule neurons (CGNs) from GSK-3P-mediated apoptosis induced by trophic withdrawal (serum/potassium deprivation). Lithium concentration-dependently (1-20 mM) protected CGNs. Indirubin, a specific, direct GSK-3P inhibitor, was also neuroprotective. On the contrary, VPA (1- 20 mM) did not provide any neuroprotection and even potentiated cell …

Cultus: The Church, The Family, And The Art-Saint, Rebekah Carmichael

Theses

None provided.

Cfd Analysis And Validation For Solution To Micro Air Vehicle Airframes, Taher I. Attari

Theses

Micro Air Vehicles (MAVs) are generally defined as having an airframe with a span less than 6 inches and a mass less than 100 grams. The design of airframes is currently hindered by the lack of thorough understanding of the flow physics of very small aircrafts flying at low speeds. The study investigates the use of Fluent, a licensed CFD code at RTT, for MAV airframe design. This study is carried out in 4 steps. First, 4 different airfoils are selected and tested in CFD. The next step included the simulation of 3-D flat plates and wing models. An external …

Investigation Of Heart Rate Variability During Sleep Apnea, Sekar Subramanian

Theses

Sleep apnea is a disorder, where there are repetitive pauses in respiratory flow of at least 10 seconds or longer duration, and which occur more than five times per hour. Apnea has strong modulating effects on the autonomic nervous system, with prominent heart rate variation. It can be assumed that during sleep, internal influences (sympathetic and parasympathetic nervous system activities) dominate the autonomic nervous system; in addition repetitive apneas are accompanied by a pronounced increase in average heart rate. The aim of this study was to investigate the heart rate variability using spectral analysis and time-frequency analysis during sleep apnea. …

An Analysis Of The Periodicity Of The Cell Cycle And Apoptotic Regulatory Proteins In Prostate Xenografts Using Anova And Cosinor Methods, Aleen Hosdaghian

Theses

Circadian rhythms have been found in both plants and animals, in normal tissues as well as in most tumors and human cancers. By following these rhythms in healthy and cancerous tissue, it has been possible to find optimal times to deliver a dose of drug, such that efficacy is maximized and toxicity to normal tissues is minimized. In this study, the periodicity of several cell cycle and apoptotic regulatory proteins were studied in two prostate cancer models against a dietary therapeutic agent, Selenium. The ALVA-3 1 (androgen-independent) and PC-3 (androgen-independent) prostate cancer cell lines were grown in vivo, as a …

Chemical Vapor Deposition Of Polymeric Films, Chi Yu

Theses

Poly-peri-naphthalene (PPN) is a one-dimensional (1 -D) graphite polymer with unique planar ladder-like conjugated molecular structure. PPN was predicted to be a good intrinsic conductor and have high thermal stability and high environmental stability.

In this project, chemical vapor deposition (CVD) and plasma enhanced chemical vapor deposition (PECVD) of carbon films with PPN structure using PTCDA as precursor were carried out under different conditions. There is only limited information in literature on the synthesis of PPN films by PECVD process, which may allow deposition at a higher rate with lower substrate temperature. In this work the influence of deposition parameters, …