Stimuli-Responsive Chemotherapy For Glioblastoma: Sequence-Dependent Synergy Of Cold Atmospheric Plasma And Ultrasound With Cationic Lipo-Doxo, Alessandro Cazzolla

Theses

Glioblastoma (GBM) is an aggressive, infiltrative astrocytic tumour in which pharmacotherapy remains constrained by the blood-brain barrier (BBB) and the heterogeneously altered blood brain tumour barrier, with additional limitations imposed by active efflux and the complexity of the tumour microenvironment. In this setting, externally addressable strategies that modulate transport and uptake at the site of disease are required. A stimuli-responsive chemotherapy platform was developed in which Lipo-DOXO was combined with two non-invasive physical modalities, low-frequency ultrasound (US) and cold atmospheric plasma (CAP), to enhance intratumoural delivery while limiting off-target effects. Liposomes were produced by thin-film hydration followed by a controlled, …

Inflection Points In Academic Career Trajectories: Statistical Modeling And Interactive Visualization, Aicha Malouche

Theses

This thesis examines the temporal structure of academic career trajectories, with a particular focus on identifying non-linear patterns of research productivity and moments of maximum acceleration in scientific impact. Situated within the broader context of bibliometric evaluation, the study responds to long-standing limitations of aggregate and linear career models that obscure heterogeneity across disciplines and national research systems. Drawing on theories of cumulative advantage, life-cycle productivity, and structural stratification, the research seeks to clarify how and when elite researchers experience peak growth in impact over the course of their careers. The study is guided by four research questions: (1) when …

Microplastics In St. John, United States Virgin Islands Sediments: Methodological Approaches And Variability Of Microplastics Concentrations And Accumulation Rates, Henry B. Arbaugh, Sarah C. Gray, Dimitri Deheyn

Theses

Sediment samples were collected from a near shore and reef site in Coral Bay, St. John, United States Virgin Islands (USVI) from 2007-2016, using tube sediment traps. These samples provide an opportunity to study microplastics (MPs) in an area where no previous MP studies have been performed. Most sedimentary MP studies utilize benthic samples which can only measure MP concentrations (#MP/g or #MP/mL sediment), while sediment traps can provide MP accumulation rates (#MP/cm²/day) as a function of time. However, the methods used for extracting MPs from benthic samples have not been tested using sediment trap samples whose characteristics, …

Investigating The Knowledge, Attitudes And Practices Towards Type 2 Diabetes Mellitus In A Student Population In The United Kingdom: A Quantitative Study, Philip Boadu Anim

Theses

Aim: To explore the knowledge on the risk factors, signs and symptoms, management, and complications of Diabetes, attitudes, and practices towards prevention of Diabetes Mellitus among university students in the United Kingdom.

Methods: The researcher utilised a quantitative study design in carrying out the study. The study was conducted at Cardiff Metropolitan University with Cardiff Met students being the target population. Thirty (30) participants were recruited through convenient sampling. Data was collected through questionnaires using closed ended questions. The Statistical Package for Social Science (SPSS) version 27 as used to analyse the data collected. Statics were performed to form a …

Assessing Localized Recovery And Synchrony Of An Endangered Wetland Species., Aiyana Reissman

Theses

The state and federally endangered light-footed Ridgway’s rail (LFRR; Rallus obsoletus levipes) is central to regional conservation, yet the drivers of its population fluctuations remain poorly understood. The fragmented nature of coastal wetlands in Southern California is threatening the existence of endemic species like the LFRR. Tidal inundation, severe storms, and overpredation threaten the survival of LFRR. This study addresses population fluctuations by analyzing the spatial and temporal drivers of LFRR populations to inform effective, site-specific management.

To do this, a 45-year (1980–2024) LFRR census data set across 16 wetlands throughout its range in California was synthesized. A multi-faceted …

Multipath Exploitation For Radar Sensing In An Urban Environment Using The Music Algorithm For Jammer Mitigation, Daniel De Zutter

Theses

With the increased push for spectrum sharing techniques, the technological world surrounding radar has been constantly pushing to find new methodologies. From being able to integrate with a communication system to mitigating the effects of other users on a system, the research community is pushing forward. We look to tackle the problem of mitigating a jammer using a multipath MUltiple SIgnal Classification (MUSIC) based approach. We take multiple steps to implement this and generate a framework for future work. We first take a look at understanding the current state of the art research surrounding DFRC, multipath exploitation, MUSIC algorithms, RIS …

Knowledge And Perception Of Human Milk Donation Among Pregnant, Lactating, And Postpartum Women In Rochester, Ny, And Near Hmbana Milk Banks, Samantha Allen

Theses

Human milk banks provide pasteurized donor milk for premature infants whose mothers are unable to produce sufficient amounts of milk, offering critical nutritional and immunological benefits for this high-risk population.1–4 Although 28 HMBANA-accredited milk banks operate in the United States, none are located within 4.5 hours of Rochester, NY. This study examined the knowledge and perceptions of human milk bank donation among pregnant, lactating, and postpartum women in Rochester, NY, and in communities near HMBANA-affiliated milk banks, and assessed if there is a correlation regarding the proximity of milk banks.  A cross-sectional study design was used, and participants completed a …

Exploring Interpenetrating Networks Derived From Compostable Polymers In Separations, Hailey Holshouser

Theses

The increasing demand for environmentally friendly and sustainable water treatment technologies drives the development of membranes that work to balance mechanical durability, tunable selectivity, and long-term stability. In this exploratory work, an interpenetrating polymer network (IPN) membrane system composed of poly(butylene adipate-co-terephthalate) (PBAT) and poly(2-hydroxyethyl methacrylate) (pHEMA) was developed to provide a more compostable and compatible platform for advanced separation applications. While the compostability of the entire framework was not tested, the dominant presence of PBAT in the matrix makes the membrane intrinsically favorable for composting. Mechanochemical Ionic Electrochromic Generators (IEGens) were synthesized and incorporated into the PBAT backbone for …

Inflex : A Scalable Framework For Malware Analysis, Correlation, And Steganography Detection, Luke Bower

Theses

Modern malware campaigns operate in stages across diverse formats, including PE, ELF, shellcode, and malicious documents, some leveraging steganography to deliver payloads such as Quasar RAT and Lokibot. Because analysis tooling remains siloed by artifact type, analysts struggle to identify shared code reuse, behavioral overlap, and campaign relationships when adversaries avoid traditional indicators. This thesis presents INFLEX, a framework that normalizes diverse artifacts through a unified pipeline combining static analysis, emulated behavioral extraction, sandbox execution, and threat intelligence enrichment. Its correlation layer introduces Variant Resilient Function Hashing (VRFH), validated against fuzzy hashing baselines on targeted samples, and Weighted Artifact Fusion …

Leveraging Ai, Iot, And Predictive Analytics For Crisis Management And Urban Resilience In Dubai, Suhail Bin Kalli

Theses

The thesis will discuss how smart technologies could be incorporated in the crisis management structures of Dubai to make the city more resilient. As Dubai grows more urbanized, it experiences increased problems with managing its crisis especially in the high population density places, traffic congestion, utility disruption, and extreme weather. This paper discusses how artificial intelligence (AI), the Internet of Things (IoT), and predictive analytics can be used to ameliorate the response to emergencies, manage the allocation of resources, and enhance the coordination between different agencies. The crisis management systems at Dubai are still ineffective despite the level of technologies …

Optimizing Marketing Campaigns To Maximize The Response Rate For A Supermarket Using Machine Learning Techniques, Alia Almansoori

Theses

Supermarkets must improve their marketing tactics at a time of changing consumer behavior and increasing competition in the retail industry. Engaging the wide and sophisticated consumer base of today's supermarkets is difficult using traditional methods. This proposal presents a data-driven approach using cutting-edge machine learning methods to enhance supermarket marketing strategies. The main goal is to increase the response rate of marketing initiatives, which will improve consumer engagement and ultimately increase revenue. Additional primary objectives are customer segmentation and targeting, predictive modeling, personalization, ongoing performance monitoring, and ROI evaluation. The current problem centers around personalization and accuracy. Due to the …

Ties Of Influence: The Armistead-Winston Network And Elite Mobility From Virginia To The Southern Frontier., Mindy L D Bates

Theses

This thesis examines how the Armistead and Winston families leveraged intergenerational kinship networks to preserve and reproduce elite authority as they migrated from colonial Virginia to the southern frontier. Rather than viewing migration as an individual pursuit, this study demonstrates that family alliances, shared resources, and long-standing ties shaped opportunity and authority across generations. Using family papers, letters, land deeds, wills, journals, and family trees, this project highlights how these connections functioned as forms of social capital that guided settlement, land acquisition, and community leadership on the frontier. This study serves as a guide for understanding how kinship networks operated …

Evaluating The Effectiveness Of Scenario-Based Virtual Escape Rooms To Improve Student Confidence In Dosage Calculations, Jennifer A. Cuevas

Theses

Abstract

Background: Accurate dosage calculations (DCs) are critical for patient safety, as medication errors contribute to approximately 7,000-9,000 preventable deaths annually. Nearly 30% of nursing students exhibit weakness in foundational mathematical skills, and a significant confidence gap exists: 70% feel confident in mathematical abilities, yet only 45% feel confident in clinical application, necessitating innovative educational interventions.

Purpose: The purpose of this project was to implement and evaluate a scenario-based virtual escape room intervention to enhance undergraduate nursing students' confidence in DCs.

Methods: Grounded in Kolb’s experiential learning theory, this online asynchronous intervention engaged students through concrete experience, reflective observation, abstract …

Increasing Confidence Of Respiratory Therapy Students In Cardiopulmonary Resuscitation Using Rapid Cycle Deliberate Practice, Heather Ashley

Theses

Background: Rapid Cycle Deliberate Practice (RCDP) simulation has emerged as an innovative approach to strengthening confidence among healthcare learners and professionals. Grounded in Kolb’s Experiential Learning Theory, RCDP emphasizes structured repetition, immediate feedback, and skill refinement through cycles of performance, reflection, and reapplication.

Methods: Senior-level respiratory therapy students participated in either a traditional cardiopulmonary resuscitation (CPR) simulation or an RCDP CPR simulation as part of their scheduled coursework. After completing the simulation, students participated in a post‑simulation survey, and scores were compared between the two groups.

Results: Confidence was evident across both simulation methods, and students indicated increased self‑confidence following …

From Tension To Teaching: Combating Incivility And Bullying Behaviors Directed At Nursing Students, Shelley Dyal

Theses

Background: The phrase “nurses eat their young” has long been used to describe the culture of incivility and bullying often directed at nursing students. These behaviors in the nursing clinical learning environment break down nurse-student relationships. To address this issue, nursing staff must have the tools to fulfill their roles as educators and mentors in clinical settings. The purpose of this project is to implement and evaluate the effectiveness of an evidence-based asynchronous educational workshop focused on incivility reduction and student mentorship among nursing staff in a rural hospital setting.

Methods:  This study used a quantitative, one-group pretest–posttest intervention design …

Empowering Change: Impact Of Motivational Interviewing On First-Semester Nursing Students' Perceived Confidence And Communication Skills, Norma L. Branyon

Theses

Background: Effective communication is vital when interacting with others, regardless of the profession. When healthcare providers lack the skills to facilitate conversations about behavior changes, poor patient outcomes can be produced. New graduate nurses often encounter difficulties in effectively communicating with patients and display reluctance to engage with patients and their families. Ineffective communication may lead to increased anxiety, miscommunication, and mistrust. This communication gap can hinder therapeutic relationships, patient engagement, and overall health outcomes. Communication plays a crucial role in student nurses’ self-confidence, motivation, and personal and professional growth. Therefore, role transition for new nurses can be difficult and …

The Southern Roots Of Populist Rhetoric And The Growth Of Fundamentalism, Ethan Teems

Theses

The religious fundamentalism of the 1920s was a direct evolution of the Southern Populist movement of the 1890s. While populism began as a political crusade against economic exploitation, industrialization, and urbanization, it evolved into a movement that attacked modernity. The southern United States was rooted in a predominantly religiously homogeneous society. The Protestant religions that encompassed the region were unwilling to adapt to a changing society, allowing religious fundamentalism to expand.

Beginning with the cultural conflicts of the 1920s, such as the Scopes Trial and William Jennings Bryan’s activism, the study explains how fundamentalists framed their struggles against modernism as …

'Guide The Tide' - Supervision Of International Medical Graduates In The Emergency Department: A Mixed Methods Study, Purnasankar Bhowmik

Theses

Australia’s emergency departments (EDs) have experienced significant stress since the COVID-19 pandemic. An increase in the number of patient presentations, a lack of in-patient beds for the disposition of admitted patients and long waiting times are contributing factors jeopardising patient safety. In addition, the shortage of skilled staff to look after patients in the ED is the paramount concern currently and moving forward. Similarly to many other specialty areas of medicine, EDs rely on international medical graduates (IMGs) to fill the gaps in the medical workforce. However, concerns have been raised regarding IMG diversity in training requirements, clinical skills and …

Optimisation Of Sampling For A New Skin Microbiome Assay Pilot Study, Anita Smith

Theses

Recent interest in the diverse ecosystem of bacteria, fungi and viruses that make up the skin microbiome has led to numerous studies investigating the microbiome in healthy skin and in dermatological diseases. An imbalance of the normal skin microbial flora can cause some skin diseases, and current culture techniques are often unable to detect a microorganism to further our understanding of the clinical–microbiological correlates of disease and dysbiosis. Atopic dermatitis and rosacea are presentations that General practitioners (GPs) often manage that may have an infective or microbiological component and can be challenging to treat. Further research using culture-independent techniques is …

Cultural Crossroads: Dubai's Cultural Influence On Mobility & The 20-Minute City Feasibility, Hiba Malik

Theses

The research explores the feasibility of the 20-minute city concept in the context of Dubai, an idea that was first proposed by Professor Carlos Moreno in 2016. While this model, which is based upon the theory that residents should be able to reach essential services within a certain time (i.e., 15 or 20 minutes), has been adopted globally in various cities across the world, its application within non-Western, high- income, car-dependent settings remains largely unexplored. For this reason, this study analyzes the 20- minute city concept in Dubai s unique context within its sociocultural, climatic, and cultural settings in the …

Leveraging Open-Source Llms For Infrastructure Drift Detection And Correction, Kemoy S. Campbell

Theses

Infrastructure as Code (IaC) enables organizations to provision and manage infrastructure at scale using version-controlled, declarative specifications. Despite these advantages, infrastructure drift where deployed resources diverge from their intended configuration remains a persistent operational challenge and is often addressed manually and reactively. Recent advances in Large Language Models (LLMs) have accelerated their adoption within software engineering and DevOps workflows; however, the sensitive nature of IaC artifacts, particularly Terraform state files, has limited organizational willingness to rely on public LLM services for drift detection and remediation. This thesis investigates the feasibility of using open-source, self-hosted LLMs to assist with IaC drift …

Reflux Micro-Aspiration: Natural History, Pathophysiology, Clinical Presentation And Treatment, Oleksandr Khoma

Theses

Background

The accurate diagnosis of gastro-oesophageal reflux pulmonary micro-aspiration has only become possible recently with the introduction of a novel technique of reflux micro-aspiration scintigraphy study combined with single photon emission computed tomography (SPECT) combined with x-ray tomography (CT) in a hybrid instrument (1-3). This has allowed the accurate diagnosis of pulmonary and airway contamination with refluxate. Previously only patients with large volume symptomatic reflux aspiration were diagnosed clinically (Mendelson syndrome) or by 2-dimentional barium meal or an older plantar (2 dimensional) technique of scintigraphic aspiration studies. The concept of reflux micro-aspiration has been implicated in multiple pulmonary diseases but …

Examining Preoperative Health And Lifestyle Risk Factors In Patients Awaiting Surgery During Covid-19 In Western Australia, Nadine Radin

Theses

This study investigated the prevalence of modifiable preoperative lifestyle risk factors among patients undergoing upper gastrointestinal and colorectal surgery at a metropolitan hospital in Perth, Western Australia (WA). It aimed to characterise behaviours such as smoking, alcohol and drug use, nutritional risk, physical fitness, frailty, and body mass index (BMI), and to examine whether these changed during the early phase of the COVID-19 pandemic in 2020 compared to 2019.

A retrospective audit of 2,340 patient medical records was conducted, with data extracted from routinely collected preadmission documentation. Regression models compared the prevalence of risk factors across matched calendar periods, adjusting …

Phytoremediation Potential Of Selected Plant Species (Ambrosia Artemisiifolia L. And Erigeron Canadensis L.) For Reducing Priority Heavy Metal And Metalloid (As, Cd, Cr, Cu, Hg, Pb, Zn) Contamination In Anthropogenically Impacted Soils Of Ukraine, Volodymyr Laptiev

Theses

Soil contamination with priority heavy metals and metalloids of anthropogenic origin represents one of the most pressing environmental challenges of the present day, directly associated with risks to public health, ecosystem degradation, and the achievement of the Sustainable Development Goals, particularly those of the World Health Organization and the United Nations aimed at ensuring a healthy environment, safe ecosystems, and sustainable land management. Under conditions of long-term technogenic pressure, compounded by the additional impact of military activities on the territory of Ukraine, the search for scientifically substantiated, environmentally safe, and economically feasible approaches to reducing soil contamination has become especially …

Evaluating The Operational Performance Of Diverging Diamond Interchanges Under High Heavy Vehicle Traffic Using Synchro Traffic Simulation Software, Hannah Duke

Theses

Diverging Diamond Interchanges (DDIs) are increasingly used to improve traffic flow and safety, particularly where left-turn volumes are high. However, their operational performance under high heavy vehicle percentages has not yet been evaluated. This thesis investigates the impact of varying HV percentages and traffic volumes at a sample DDI location. Traffic simulation using Synchro software was used to model the DDI under scenarios with varying heavy vehicle percentages and varying volumes. This approach allowed evaluation of traffic growth and increasing heavy vehicle presence on DDI performance, capturing realistic operational conditions for freight-heavy corridors. Key performance measures included average control delay, …

Characterization Of Krypton Ion Sputtering Of Spacecraft Materials Using Electric Propulsion, Ethan Cummins

Theses

In the field of electric propulsion (EP), xenon is the most commonly used gas for ionization. However, krypton has been identified as a potential substitute due to its high specific impulse and low cost compared to xenon. Therefore, there is a desire to understand the effects of using krypton. In EP, sputtering of spacecraft materials downstream of the ion engines have proven to be an issue during long duration missions. This research observes how krypton ions sputter a variety of spacecraft materials (anodized aluminum, glass, BN ceramic, and Kapton). The experiments in this study subject materials to different sputtering variables …

Spatially-Distributed Imu Array Navigation : Virtual Imu And Federated Approaches With Applications To Uncrewed Aerial Systems, Jackson Neese

Theses

This thesis investigated lever arm effects on distributed inertial measurement unit (IMU) array navigation and evaluated the performance of multiple fusion architectures with applications to uncrewed aerial systems (UAS). The Kalman Filters comprise of three filters: a naive baseline, a filter tracking lever arm as a filter state, and a filter constraining lever arm state estimates around known values. These filters feed into a virtual IMU fusing raw measurements and a federated filter combining output states. Each are evaluated with equal, static, and dynamic weighting based on lever arm and sensor noise. Experiments on indoor and outdoor UAS datasets reveal …

System-Level Analysis And Experimental Testing Of A Rotating Detonation Rocket Engine With Water Electrolysis Propellants, Justin M. Byers

Theses

This work explores the potential benefits and practical feasibility of a rotating detonation rocket engine (RDRE) spacecraft thruster using water electrolysis for propellant generation. Such a thruster can enable the use of liquid water as an easily storable and chemically inert propellant, as well as the volume and efficiency benefits associated with detonation combustion. A thermodynamic model is first developed to demonstrate the compounding advantages of both water electrolysis propellant generation and detonation combustion when compared to conventional isobaric combustion cycles. Comparisons are also drawn to alternative water-powered propulsion methods and the advantages of chemical propulsion are observed. The representative …

Enhanced Pulsar Timing Precision For The Era Of Nanohertz Gravitational Wave Astronomy, Sofia V. Sosa Fiscella

Theses

In 2023, several international collaborations comprising the International Pulsar Timing Array achieved a major scientific milestone with the first detection of a signal in pulsar timing observations consistent with the signature expected from a stochastic gravitational wave background, created by an ensemble of unresolved supermassive black hole binaries in the early Universe. The next breakthrough in the field is expected to be the first detection of a continuous wave from a single such binary, which would allow us to better understand their evolution and that of our Universe. However, this feat will require unprecedented precision in our timing measurements. To …

Predicting Undergraduate Fallout And Success, Ammar Ahmed Alzarooni

Theses

Universities need to uncover students who are likely to drop out early and do something about it. It should be easy to find and use this information. This thesis evaluated interpretable machine-learning models (MLMs) for predicting three final student outcomes including Dropout, Enrolled and Graduate, using solely demographic, administrative/financial and first-semester academic variables. Study employed publicly accessible Portuguese UCI student retention dataset (4,424 records) and incorporated end-of-Semester-1 feature window to prevent look-ahead leakage and align with actual advising cycles. We trained and compared models using stratified validation, explicit class-imbalance handling and decision-threshold optimization to make dropout detection most critical factor. …