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Societal Impact Assessment Of Depression, Mohammed Salah Almazrouei Nov 2022

Societal Impact Assessment Of Depression, Mohammed Salah Almazrouei

Theses

Depression is a mental problem characterised by unusual changes in the mood of a person, accompanied by a temporary different emotional response to everyday changes in the phenomena (WHO, 2020). Affected people suffer greatly, hence functioning poorly in the workplace, school, or at home in a family setup. Even though the public is well aware of its existence, there is little going on to combat this condition. Amongst the various stumbling blocks towards achieving an effective approach to address the problem include limited resources and associated well-trained personnel to help the victims.

A mental disorder associated with social stigma and …


An Appreciative Inquiry Of Community Based Disability Sports And Physical Activity Provision To Guide Future Development, Jennifer O Carroll Reidy Nov 2022

An Appreciative Inquiry Of Community Based Disability Sports And Physical Activity Provision To Guide Future Development, Jennifer O Carroll Reidy

Theses

In 2008, the Irish Sports Inclusion Disability Programme (SIDP) was established to provide opportunities for people with disabilities to participate in a variety of sports and physical activity. Regular monitoring has been sporadic and disparate (Sport Ireland, 2016). Using the four-stage method of Appreciative Inquiry (Cooperrider, 1987), a series of interviews was undertaken with providers of the SIDP. Fourteen Coordinators, SIDOs and sports development workers were interviewed about the strengths, impacts and future for the SIDP. Six participants of the programmes also took part in a focus group concerning their perspectives of the current state and future potential for the …


Phubbing And Fear Of Missing Out As Mediators Between Problematic Social Media Use And Life Satisfaction Among Young Adults, Najeera Peer Meera Levai Nov 2022

Phubbing And Fear Of Missing Out As Mediators Between Problematic Social Media Use And Life Satisfaction Among Young Adults, Najeera Peer Meera Levai

Theses

Recent studies have shown certain risk indicators for young adults' decreased life satisfaction as a result of excessive social media use. However, few studies have looked at possible impact of problematic social media on life satisfaction, and less information is known about the mediating factors that contribute to this association. The purpose of the current study was to determine whether problematic social media use predicts life satisfaction among young adults. It also explored whether phubbing behaviour and fear of missing out might both serve as mediators in this relationship. A sample of 351 young adults (18–25, Mage = 19.74 …


Effect Of Carnosol On G Protein-Coupled Receptor Signaling In Cancer Cells, Laith Jehad Ahmad Abudawood Nov 2022

Effect Of Carnosol On G Protein-Coupled Receptor Signaling In Cancer Cells, Laith Jehad Ahmad Abudawood

Theses

Carnosol is a plant polyphenol compound known for its beneficial properties against human diseases such as cancer and diabetes. However, the exact molecular and cellular mechanisms involved, and its molecular targets are not fully known. Carnosol was shown to bind and to modulate specific intracellular signaling proteins in cancer cell lines. In this study, we hypothesized that carnosol may pharmacologically target specific cell surface receptors including G Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinase (RTKs). Therefore, we tested the pharmacological effect of carnosol on the following receptors: Insulin Receptor (IR), Chemokine CXCL12 Receptor (CXCR4), Angiotensin II (AngII) Receptor (AT1R), Glucagon-Like …


Analysis Of The Relationship Between Ieq And Energy Consumption In Uae University Building: Impact Of Thermal And Lighting Comfort On Energy Usage, Salama Abdulla Al Ghaithi Nov 2022

Analysis Of The Relationship Between Ieq And Energy Consumption In Uae University Building: Impact Of Thermal And Lighting Comfort On Energy Usage, Salama Abdulla Al Ghaithi

Theses

The Indoor Environment Quality (IEQ) of buildings becomes increasingly critical as people spend more than 90% of their time inside buildings based on the National Human Activity Pattern Survey (NHAPS) (Klepeis et al., 2001). The quality of the indoor environment in a building has been shown to have a significant impact on users' productivity and energy consumption. Further, if tenants are working in a comfortable indoor environment, absenteeism rates and incidental expenses, such as medical expenses, will be reduced. For instance, a comfortable workplace increases productivity by 10-15% and reduces absenteeism by 2.5% (Leyten & Boerstra, 2003). According to the …


Investigating Teachers’ And Lead Teachers' Perspectives On The Impact Of Stream On Enhancing Teaching, Learning And Professionalism In The Emirates Schools Establishment, Hosam Rashad Badawy Nov 2022

Investigating Teachers’ And Lead Teachers' Perspectives On The Impact Of Stream On Enhancing Teaching, Learning And Professionalism In The Emirates Schools Establishment, Hosam Rashad Badawy

Theses

STREAM education is the latest development of STEM and STEAM educational approaches in the United Arab Emirates schools. It is gaining traction because of the global market's massive economic and technological advancement, as STREAM employment is in growing demand. Educational policymakers and leaders in the UAE advocate for the development and implementation of STREAM to enhance innovation and entrepreneurship skills, leading to a drastic shift in teaching, learning and professionalism. According to the study, the STREAM approach enhances teachers' professionalism, students' creative skills and the learning of 21st century survival skills such as communication, collaboration, creativity, critical thinking, digital …


Piezoelectric Enhanced Noninvasive Laser-Based Detection Of Multiple Vital Signs, Ahmed Saeed Dabi Nov 2022

Piezoelectric Enhanced Noninvasive Laser-Based Detection Of Multiple Vital Signs, Ahmed Saeed Dabi

Theses

In this study, a method for concurrent measurement of heart rate (HR) respiration rate (RR) and blood pressure (BP) using movements of the chest wall is proposed. Unlike conventional approaches that use only laser, in this approach a laser source is used to collect the piezoelectric sensor output without the need for probing. The chest wall movements are transduced using an optical ODSL 8 sensor and a piezoelectric taped to the patient’s chest. Measurement data is used for development of algorithms for estimation of HR, RR and BP. Next measurements are taken while the subjects are breathing and holding their …


English Language Teachers’ Perceptions Of And Experiences With Online Project-Based Learning, Jocelle Marianne M. Barican Nov 2022

English Language Teachers’ Perceptions Of And Experiences With Online Project-Based Learning, Jocelle Marianne M. Barican

Theses

The main objective of this research is to investigate schoolteachers’ perspectives on the use of online Project-Based Learning (PBL) in English classes in the UAE during the COVID19 pandemic. The research explores the teachers’ perceived benefits and challenges of the PBL approach. Another aim of this research is to identify if teachers’ gender, years of experience, and familiarity with PBL have an impact on how they view the use of PBL in their classes. The study utilized two instruments to collect data: a survey with close-ended and open-ended questions, and a semi-structured interview. The survey responses were collected from 87 …


Why Post- Leaving Certificate Students In Ireland From Disadvantaged Backgrounds Are Less Likely To Proceed To Third-Level Education, Edward Hayes Nov 2022

Why Post- Leaving Certificate Students In Ireland From Disadvantaged Backgrounds Are Less Likely To Proceed To Third-Level Education, Edward Hayes

Theses

Educational disadvantage continues to be a cause for concern, and addressing it remains at the forefront of education policy in Ireland (Houses of Oireachtas, 2019; Weir et al., 2017). This research extended across the academic years 2019-2020 and 2020-2021 and during the period of the global COVID-19 pandemic, which imposed public health measures, and enforced an emergency online digital learning environment. A socio-economic profile of Ireland’s student body registered an attainment gap between rich and poor, finding that young people from backgrounds of disadvantage continue to be underrepresented at third-level when compared to their middle-class counterparts (HEA, 2020). The primary …


Tailoring The Rehabilitative Environment For People With Sensory Overload, Jennifer Cotter Nov 2022

Tailoring The Rehabilitative Environment For People With Sensory Overload, Jennifer Cotter

Theses

Sensory overload is a complex sensory processing disorder which can develop post Acquired Brain Injury (ABI). The condition can be extremely debilitating and people who develop it are further hampered by lack of informational resources, sensory overload is currently under researched in the Acquired Brain Injury rehabilitation sector. This qualitative study documents participants first hand experiences of sensory overload post ABI and includes insights and observations from professionals working in the Acquired Brain Injury rehabilitation sector in Ireland. In this study, sensory overload is the focal point and a new rehabilitation tool in the form of a sensory menu is …


Improving The Growth Performance Of The Mangrove Avicennia Marina Seedlings Using Plant Growth Promoting Actinobacteria, Alanoud Abdulla Al Shamsi Nov 2022

Improving The Growth Performance Of The Mangrove Avicennia Marina Seedlings Using Plant Growth Promoting Actinobacteria, Alanoud Abdulla Al Shamsi

Theses

The combination of commercial fish emulsion (FE) and plant growth-promoting actinobacteria capable of producing plant growth regulators (PGRs) was evaluated as a biofertilizer to enhance growth and development of grey mangrove (Avicennia marina) in the United Arab Emirates. In vitro studies identified the rhizosphere-competent Streptomyces griseorubens UAE1 (Sg) that was able to solubilize phosphorus, produce auxins, cytokinins, gibberellic acid, polyamines, and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase. Growth promotion, nutrient contents and PGR levels in tissues of treated mangrove plants with fish emulsion and/or S. griseorubens UAE1 were further assessed in vivo. Under greenhouse and natural open-field nursery conditions, …


Maternal Effects On Growth Parameters Of Chloris Gayana Under Co2 Enrichment, Ahmed Adnan Mohammed Mashli Nov 2022

Maternal Effects On Growth Parameters Of Chloris Gayana Under Co2 Enrichment, Ahmed Adnan Mohammed Mashli

Theses

Rhodes grass, Chloris gayana, is commonly used forage plant for grazers, livestock, and cattle. It significantly improves soil fertility and its overall structure by preventing nematode flourishment in soil. It is also used as a cover crop to upgrade soil health by reducing soil erosion and increasing water availability. The present study assessed the effects of CO2 on the growth, development and maternal effects of C. gayana. The experimental setup was made in such a way that the potential impacts of CO2 can be measured on the eco-physiological growth of C. gayana by studying successive generations. Generation 1 …


Heterodimerization Between Chemokine Receptors Cxcr4 And Ccr7 And Its Role In Cancer, Maryam Naveed Muhammad Tariq Nov 2022

Heterodimerization Between Chemokine Receptors Cxcr4 And Ccr7 And Its Role In Cancer, Maryam Naveed Muhammad Tariq

Theses

In physiology, the functional and physical interactions between cell surface receptors for signal molecules such as hormones, neurotransmitters, and cytokines, provides an important mechanism of diversity and regulation of signal transduction. Therefore, investigating the functional interactions between these receptors is of great importance for understanding their role in physiology and pathophysiology with potential application in drug discovery. In this context, numerous evidences support the implication of two chemokine receptors, CXCR4 and CCR7, in many cancer types. In this study, we hypothesized that the functional, and perhaps the physical interaction, occurring between CXCR4 and CCR7 may constitute one of the key …


Modified Titani Derived From Ti – Oxo Clusters: Synthesis, Structure, And Photocatalytic Activity, Fatmah Rashed Ali Alkindi Nov 2022

Modified Titani Derived From Ti – Oxo Clusters: Synthesis, Structure, And Photocatalytic Activity, Fatmah Rashed Ali Alkindi

Theses

Titanium dioxide (TiO2), an important semiconductor, has been used in various applications ranging from sunblock additives to self-cleaning window coatings, antibacterial agents, photovoltaics, and photocatalysis. Due to its photostability, TiO2 is an extensively used semiconductor photocatalyst in many industries. This thesis represents the synthesis, structure, and photocatalytic activity of TiO2 (Anatase) photocatalyst, which was prepared using hexanuclear titanium-oxo cluster precursor via temperature-controlled calcination. The optical property of the prepared photocatalyst was investigated using UV-Vis diffuse reflectance spectroscopy (UV-Vis DRS), powder X-ray diffraction (PXRD) for phase determination, scanning electron microscopy (SEM) for morphology and structural analysis, Brunauer−Emmett−Teller …


Addictive Social Media Use: Examination Of The Psychometric Properties Of The Arabic Bergen Social Media Addiction Scale And The Mediational Role Of Sense Of Control In The Relationship Between Depression And Social Media Addiction, Louis J. Fourie Nov 2022

Addictive Social Media Use: Examination Of The Psychometric Properties Of The Arabic Bergen Social Media Addiction Scale And The Mediational Role Of Sense Of Control In The Relationship Between Depression And Social Media Addiction, Louis J. Fourie

Theses

The period of COVID-19 has proven to be a turbulent period where extreme psychological trends can be examined due to lockdown procedures, social isolation, and public fear. The use of technology such as social media has increased with research highlighting the harm of overuse. The purpose of the current study is to investigate the psychometric properties of an Arabic translated version of the Bergen Social Media Addiction Scale (BSMAS) to assess for addictive social media use. Secondly, the study further examines the association between depression, social media addiction, and an individual’s sense of control. Specifically, the potential mediational role of …


Neural Network Based Reactive Control Of Point Absorber Wave Energy Converters, Abdelmoamen Ali Nasser Nov 2022

Neural Network Based Reactive Control Of Point Absorber Wave Energy Converters, Abdelmoamen Ali Nasser

Theses

The main objective of this work is to develop a neural-network-based Reactive Control (RC) system for wave energy converters. The ability to maximize the power output of WEC while maintaining operation constraints, which can be physical or thermal, is crucial to the development of deployable control strategies. Having a control method that is robust, which means it handles uncertainty and noise very well, is one of the main performance criteria in evaluating the method. Therefore, this work starts by deriving an averaged WEC model to be simulated in MATLAB/Simulink. Additionally, the concepts of resistive loading control and reactive control (approximate …


The Effect Of Licogliflozin (Sglt1/2 Inhibitor) On Diabetes And Cardiac Complications, Alanoud Gharib Alblooshi Nov 2022

The Effect Of Licogliflozin (Sglt1/2 Inhibitor) On Diabetes And Cardiac Complications, Alanoud Gharib Alblooshi

Theses

Diabetes mellitus (DM) is a chronic endocrine disease affecting millions of people worldwide. In spite of the advances made in the management of DM, poor glycemic control and diabetes complications are still very common. There is a continuous search for new and more effective drugs to treat DM. One of the drugs currently in clinical trials for the treatment of DM is licogliflozin (LIK066), a dual SGLT1/2 inhibitor, which can be used to treat obesity and diabetes. LIK066 inhibits glucose reabsorption in the kidney and small intestine, thereby reducing hyperglycemia. This study aims to investigate the efficacy of licogliflozin on …


On The Projections Of Commutative C*-Algebras, Alaa Ahmad Hamdan Nov 2022

On The Projections Of Commutative C*-Algebras, Alaa Ahmad Hamdan

Theses

Gelfand and Naimark proved that the Banach algebra of continuous complex-valued functions on a compact space Ω is the only example of commutative unital C*-algebras. We study the C*-algebra C(Ω) and its main elements, such as projections. Also, we discuss the mapping between projections, which preserves orthogonality (orthoisomorphism). A bijective θ between projections induces a bijective Θ between the Boolean algebra of clopen subsets of X. Then, we give main properties of such Θ. For a compact subset X of ℝ, we classify the projections of C(X) by introducing the similar relation on P(C(X)). We introduce an …


Investigating The Factors Impacting School Leadership’S Feedback And Feedforward Receptivity And Learning As Perceived By The Emirates Schools Establishment Staff, Hesham Rashad Badawy Nov 2022

Investigating The Factors Impacting School Leadership’S Feedback And Feedforward Receptivity And Learning As Perceived By The Emirates Schools Establishment Staff, Hesham Rashad Badawy

Theses

This thesis is concerned with “Investigating the Factors Impacting School Leadership’s Feedback and Feedforward Receptivity and Learning as Perceived by the Emirates Schools Establishment Staff”. The study aims to identify if there is any existing interplay between the four domains: mindset, feedback orientation, feedback environment, and learning climate and how they impact feedback receptivity and learning. The study utilizes an explanatory sequential mixed research method. The rigorous quantitative data from the 5-point Likert scale survey was used as a basis for the semi-structured interview discussions after calculating the scores for each domain and staff member. The findings of the first …


Investigating The Role Of Irc20 And Cdc48 In The Maintenance Of Yeast Genome, Asma Albadi Alnuaimi Nov 2022

Investigating The Role Of Irc20 And Cdc48 In The Maintenance Of Yeast Genome, Asma Albadi Alnuaimi

Theses

DNA, the basic unit of inheritance, is continuously exposed to numerous endogenous and exogenous damaging agents that compromise its function and adversely impact health. However, the cell has evolved intricate DNA repair mechanisms to mitigate the negative consequences of genomic instability. The repair of DNA double-strand break (DSB) is potentially accomplished by various mechanisms, including homologous recombination (HR). An HR-mediated DSB repair requires controlled regulation of repair proteins to ensure timely function. Posttranslational modifications (PTMs), such as ubiquitylation and SUMOylation, are regulatory mechanisms that significantly fine-tune proteins activities. Central to these processes is Rad52, a conserved oligomeric protein that forms …


حمایة حقوق الملكیة الفكریة بنظام السجل الرقمي (البلوكتشین), حصة محمد الكعبي Nov 2022

حمایة حقوق الملكیة الفكریة بنظام السجل الرقمي (البلوكتشین), حصة محمد الكعبي

Theses


Protection of Intellectual Property Rights through the Digital Recording System (Blockchain)

The digital ledger system (Blockchain) appeared in 2008 by the Japanese programmer Satoshi Nakamoto, and his innovation came to ensure the circulation of the digital currency Bitcoin. The digital system (blockchain) has been likened to a digital record; In which information is stored and documented in an elaborate manner that is difficult to penetrate.

The UAE government has adopted the technology of digital transactions (Blockchain) in executing government transactions. To achieve the desired results, the country launched the UAE Digital Transactions Strategy 2021 and the Dubai Digital Transactions Strategy. …


Virtual Laboratories For Stem Education: An Evaluation Model And Comparison, Jumana Mahmoud Kharsa Nov 2022

Virtual Laboratories For Stem Education: An Evaluation Model And Comparison, Jumana Mahmoud Kharsa

Theses

Laboratory work is key to science education, and virtual environments play a vital role in remote learning. This thesis is concerned with the evaluation of virtual laboratories used in educational fields, mainly in STEM courses. This research investigates the basic criteria for evaluating virtual environments used in science education in order to create an evaluation scale. We reviewed the literature to highlight the main guidelines of evaluating virtual laboratories and found that the most common evaluation features for virtual tools are Ease of Use, Usefulness, Motivation, Interface Design, and Realism. Upon generating the assessment scale, we selected two web-based interactive …


Enhancement Of Phenolic Recovery And Bioactivity Of Date Palm Leaf Extract Using Natural Deep Eutectic Solvents And Green Extraction Technology, Raghad Shehadeh Abdal Rahman Nov 2022

Enhancement Of Phenolic Recovery And Bioactivity Of Date Palm Leaf Extract Using Natural Deep Eutectic Solvents And Green Extraction Technology, Raghad Shehadeh Abdal Rahman

Theses

This study was designed to explore date palm leaves, an agro by-product, as a potential source of natural polyphenolic compounds using appropriate green Natural Deep Eutectic Solvent (NADES) and emerging green extraction technologies. Herein, six different NADES were prepared using six different hydrogen donors and choline chloride as hydrogen bond acceptor at a molar ratio of 1:2 (w/w) and different NADES concentrations (10, 20, 40, and 80%, in water, at 40°C). Among the studied NADES, Glycerol-based NADES showed higher phenolic yield compared to saccharide and organic acid-based NADES. Afterward, to enhance the extraction efficiency, NADES were coupled with microwave (MAE-NADES) …


Design Of Low-Cost Power Quality And Energy Monitoring System For Low Voltage Distribution Network, Rami Moustafa Mohyeldeen Nov 2022

Design Of Low-Cost Power Quality And Energy Monitoring System For Low Voltage Distribution Network, Rami Moustafa Mohyeldeen

Theses

The constant increase of non-linear loads and the future high integration of renewable energy sources in the power grid make power quality monitoring systems crucial to maintain maximum efficiency and reliability. However, the current devices for power quality monitoring are costly, limiting PQ monitoring systems' usage to specific applications and for a particular time. This thesis aims to present a design and the implementation of a low-cost power quality monitoring system using a single-board computer (Raspberry Pi) and highly accurate multiphase power quality monitoring ADE9000 IC. The proposed PQM system is configured to work remotely through either a wireless connection …


الصلح الجزائي كبدیل للدعوى الجزائیة (دراسة مقارنة بین القانون الإماراتي والقانون المصري), فاخرة سیف المنصوري Nov 2022

الصلح الجزائي كبدیل للدعوى الجزائیة (دراسة مقارنة بین القانون الإماراتي والقانون المصري), فاخرة سیف المنصوري

Theses

Penal Conciliation as an Alternative Settlement of the Criminal Case (Comparative Study between Emirati Law and Egyptian Law)

This study compares the UAE Criminal Procedures Law to the Egyptian Criminal Procedures Law and examines the penal reconciliation system as a procedural system that aims to end litigation without a criminal case. In addition to demonstrating the nature of penal reconciliation, this study clarified the procedural provisions of the penal conciliation system and their implications.

Given that this study focuses on the penal reconciliation system, I chose to support my arguments about the nature of reconciliation and its procedural requirements with …


Lactic Acid Bacteria Isolated From Fresh Vegetable Products: Potential Probiotic And Postbiotic Characteristics Including Immunomodulatory Effects, Fatima Khaled Alameri Nov 2022

Lactic Acid Bacteria Isolated From Fresh Vegetable Products: Potential Probiotic And Postbiotic Characteristics Including Immunomodulatory Effects, Fatima Khaled Alameri

Theses

The ability to perform effectively in the gastrointestinal system (GIT) is one of the most significant criteria for selecting the best probiotic bacteria. Thus, the present study aimed to investigate the potential probiotic characteristics of some selected lactic acid bacteria (LAB) isolated from vegetable products. Probiotic characteristics included tolerance to acid and bile, cholesterol removing ability, bile salt hydrolysis, resistance against lysozyme and antibiotics, production of exopolysaccharides (EPS), antimicrobial and hemolytic activities, and cell surface characteristics (auto-aggregation, co-aggregation, and hydrophobicity). Out of 46 isolates, 17 isolates that exhibited remarkable survivability under gastrointestinal conditions were selected for further analysis. Almost all …


سلطات الإدارة في العقد الإداري بين مقتضيات الصالح العام والتوازن المالي, جاسم محمد سعيد الشرياني Nov 2022

سلطات الإدارة في العقد الإداري بين مقتضيات الصالح العام والتوازن المالي, جاسم محمد سعيد الشرياني

Theses

This study deals with the concept of financial balance of the administrative contract as a right of the contracting party against the exceptional and unusual powers the Administration enjoys in this type of contracts in the light of the legislation and judicial rulings in the United Arab Emirates at the federal and local levels of the Emirate of Abu Dhabi. The study clarifies the concept of the financial balance of the contract, the legal nature of such concept and the circumstances of establishment of this concept. As well as this study deals with the powers vested in the contracting Administration, …


Utilizing Date Pits In Microencapsulation: Effect Of Different Variations On Probiotic Survivability Under In Vitro Digestion, Asmaa Samir Al Hamayda Nov 2022

Utilizing Date Pits In Microencapsulation: Effect Of Different Variations On Probiotic Survivability Under In Vitro Digestion, Asmaa Samir Al Hamayda

Theses

This work deals with the medicinal use of date pit powder, which turns it from a waste product to a useful stabilizer for the release of beneficial probiotics in the human intestine. The main objective of this work is to encapsulate probiotics with date pit beads and their subsequent release in the human intestine. The beads were formed using gravitational dripping technique, while INFOGEST protocol was used to test the digested beads and the release of viable probiotic cells. For the three date varieties Raziz, Naghal and Khadrawy, it was found that 0.1 g of date pit powder per 0.2 …


The Effect Of Experiential Avoidance And Committed Action On The Relationship Between Anxiety And Quality Of Life In Chronically Ill And Healthy Students, Rufaida Mohammed N Alkhanji Nov 2022

The Effect Of Experiential Avoidance And Committed Action On The Relationship Between Anxiety And Quality Of Life In Chronically Ill And Healthy Students, Rufaida Mohammed N Alkhanji

Theses

Chronic illness and anxiety are two factors that have been shown to negatively impact quality of life. In order to better understand the impact of chronic illness on quality of life, researchers have been interested in studying the effects of experiential avoidance and committed action. This thesis aims to examine the roles of experiential avoidance and committed action as potential mediators in the relationship between anxiety and quality of life. It also aims to compare the occurrence of the studied relationships in students with and without chronic illness. 547 participants from two Arab universities completed self-report measures assessing their levels …


The Potent And Selective Histamine H3 Receptor Antagonist E169 Alleviates Cognitive Deficits And Mitigates Disturbed Pi3k/Akt/Gsk-3Β Signaling Pathway In Mk801-Induced Amnesia In Mice, Sabna Tagelsir Hassan Abdalla Nov 2022

The Potent And Selective Histamine H3 Receptor Antagonist E169 Alleviates Cognitive Deficits And Mitigates Disturbed Pi3k/Akt/Gsk-3Β Signaling Pathway In Mk801-Induced Amnesia In Mice, Sabna Tagelsir Hassan Abdalla

Theses

The role of Histamine H3 Receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s Disease (AD) is well-accepted. Therefore, the procognitive effects of acute systemic administration of H3R antagonist E169 (2.5-10 mg/kg, i.p.) on MK801- induced amnesia using the Novel Object Recognition Test (NORT) paradigm in C57BL/6J mice were evaluated. E169 (5 mg) provided a significant memory-improving effect on MK801-induced short- and long-term memory impairments in NORT. The E169 (5 mg) provided effects were comparable to those observed with the Phosphatidyl Inositol 3-Kinase (PI3K) inhibitor LY294002 and were abrogated with the …