Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (440)
- Arts and Humanities (379)
- Business (312)
- Education (310)
- Medicine and Health Sciences (263)
-
- Psychology (138)
- Engineering (131)
- Physical Sciences and Mathematics (85)
- Art and Design (60)
- Life Sciences (52)
- Computer Sciences (50)
- Philosophy (45)
- Business Administration, Management, and Operations (43)
- History of Art, Architecture, and Archaeology (43)
- Nursing (43)
- Marketing (42)
- Curriculum and Instruction (41)
- Religion (40)
- Biomedical Engineering and Bioengineering (38)
- Operations Research, Systems Engineering and Industrial Engineering (38)
- Human Resources Management (34)
- Public Health (31)
- Architecture (30)
- Counseling (30)
- Theatre and Performance Studies (30)
- Communication (28)
- Sociology (27)
- Teacher Education and Professional Development (26)
- Art Practice (23)
- Economics (23)
- Institution
-
- Rochester Institute of Technology (2123)
- Lindenwood University (924)
- The University of Notre Dame Australia (230)
- New Jersey Institute of Technology (215)
- Munster Technological University (161)
-
- University of Missouri, St. Louis (154)
- United Arab Emirates University (146)
- Southern Illinois University Carbondale (130)
- University of Alabama in Huntsville (104)
- Sigma Theta Tau International Honor Society of Nursing (49)
- Seton Hall University (36)
- North Carolina Agricultural and Technical State University (35)
- University of North Alabama (28)
- Technological University Dublin (26)
- Jacksonville State University (22)
- University of San Diego (10)
- Zayed University (7)
- St. Mary's University (3)
- Alabama State University (1)
- Edith Cowan University (1)
- Keyword
-
- None provided (153)
- Photography (92)
- Thesis (71)
- Art (67)
- Graphic design (63)
-
- Design (59)
- Painting (56)
- Psychology (52)
- Education (45)
- Fine art (45)
- Sculpture (42)
- Animation (38)
- Ireland (38)
- Machine learning (38)
- Children (37)
- Social media (37)
- School psychology (35)
- Communication (33)
- Women (33)
- Memory (28)
- Depression (26)
- Motivation (24)
- Perception (24)
- Philosophy (24)
- Artificial intelligence (21)
- Marketing (21)
- Mental health (21)
- Film (20)
- Gender (20)
- Art therapy (19)
- Publication Year
- Publication Type
Articles 511 - 540 of 4405
Full-Text Articles in Entire DC Network
Exploring Food And Physical Activity Behaviours Of Adolescents After Bariatric Surgery: A Qualitative Study, Baraa Osama Alries
Exploring Food And Physical Activity Behaviours Of Adolescents After Bariatric Surgery: A Qualitative Study, Baraa Osama Alries
Theses
In recent years, both globally and in the United Arab Emirates, adolescent obesity has emerged as a severe public health concern. Bariatric surgery is a viable treatment for adolescent obesity. However, an equally important aspect is examining the lifestyle changes, specifically concerning dietary habits and physical activity after this surgical intervention. Moreover, there is limited research on the postoperative nutrition-related nutritional and physical activity behaviors of adolescents after bariatric surgery globally, regionally, and in the UAE. The main aim of this study was to explore barriers and facilitators of diet and physical activity regimens of adolescents who had undergone bariatric …
An Examination Of The Association Between Sleep Quality And Psychological Distress Among University Students In The Middle East: A Cross-Sectional Correlational Study, Ayesha Saeed Alsuwaidi
An Examination Of The Association Between Sleep Quality And Psychological Distress Among University Students In The Middle East: A Cross-Sectional Correlational Study, Ayesha Saeed Alsuwaidi
Theses
Literature reviews have revealed that there are limited studies on sleep quality in the United Arab Emirates (UAE) and that few studies are available in the Middle Eastern region. The objective of this study was to examine the association between sleep quality and psychological distress among university students in the Middle East. A correlational cross-sectional design was determined, and a self-administered online questionnaire was used. The electronic survey was circulated amongst students on campus and received 435 responses from three universities namely, Menoufia University in Egypt, Sultan Qaboos University in the Sultanate of Oman, and United Arab Emirates University in …
Perceived Speed In Transitions Between Neutral And Chromatic Illumination, Abby Weymouth
Perceived Speed In Transitions Between Neutral And Chromatic Illumination, Abby Weymouth
Theses
Lighting that gradually changes over time, also known as dynamic lighting, is an integral part of our experience of illumination. Daylight is a prime example of this, and LED technology has led to its increasing use in artificial lighting as well. However, perception of dynamic lighting has not been extensively studied. Previous work has focused exclusively either on daylight illumination or relatively chromatic illumination, and most research examined lighting transitions at speeds near detection thresholds. Past studies have found that the perception of illumination changes is far from uniform across color space. Perception of transitions has been found to vary …
Designing For A Local Brand Image Of Architecture To Achieve Cultural Sustainability: Al Ain City As A Case Study, Dana Bassam Bidoun
Designing For A Local Brand Image Of Architecture To Achieve Cultural Sustainability: Al Ain City As A Case Study, Dana Bassam Bidoun
Theses
Cities, like Al Ain, are dynamic entities, echoing the diverse rhythms and values of their inhabitants. Urban evolution showcases a city's brand-its unique identity sculpted by historical, cultural, and local influences. A city's true essence emerges when architects collaborate with residents, blending their desires with the city's architectural legacy. This study aimed to evaluate the effectiveness of a brand-based design strategy, integrating the architecture process with insights from local residents to foster a sense of identity and belonging in the built environment. Grounded in the personal construct theory, the research applied the repertory grid technique, combining both qualitative and quantitative …
Dress-Code Violation Detection In Arabic Regions Using Object Detection Machine Learning Model, Maha Sadat Aghaei
Dress-Code Violation Detection In Arabic Regions Using Object Detection Machine Learning Model, Maha Sadat Aghaei
Theses
The dress code violation detection system is crucial for assessing clothing appropriateness in public areas. This study aims to improve this system using advanced computer vision and machine learning techniques to more effectively categorize people's attire in images and videos. To enhance adaptability and create a user-friendly graphical interface for system management and deployment, we have generated a unique dataset from various contexts mix of Western and Arabic clothing. This allows users to interact with graphical components, including the ability to upload images or use live video for clothing detection. Moreover, we have taken privacy concerns into account and implemented …
Data Sharing And School Improvement: A Phenomenological Study Of Source, Mechanisms, Lacunes And Usefulness, Maitha Khalifa Al Mansoori
Data Sharing And School Improvement: A Phenomenological Study Of Source, Mechanisms, Lacunes And Usefulness, Maitha Khalifa Al Mansoori
Theses
This study aimed to gain a better understanding of the datafication process and determine whether it contributes to school improvement in public schools. A particular focus was placed on investigating the methods used in data collection from various sources, the mechanisms in place for data sharing, the ways in which data are collected and shared, the gaps in data sharing, and the ways in which school administrators and teachers are sharing data for the school improvement. The use of a transcendental phenomenological approach contributes to the development of a theoretical model that illustrates how school data sharing works and how …
The Association Between Attachment Styles And Binge Eating Behaviours: Examination Of The Mediational Role Of Emotional Dysregulation In The Arab Region, Diala Kassab
Theses
Many factors are said to affect binge eating behaviours, one of these factors is the individual’s attachment style. Attachment styles is the early relationship that shape a child's ideas and expectations about themselves and the availability of other people. This can be mediated by the ability to effectively respond and manage emotional experiences. This thesis aimed to examine the role of emotional dysregulation on attachments styles and binge eating behaviours in the Arab region.
/="/">A sample of 326 Arab university students, predominantly Emirati and Lebanese, were recruited using convenience sampling and snowball sampling technique. Participants were asked to complete …
Examining The Parallel Mediating Effect Of Emotion Dysregulation And Eating Beliefs In The Association Between Low Self¬-Esteem And Binge Eating Behaviours, Farah Al Mohammed
Examining The Parallel Mediating Effect Of Emotion Dysregulation And Eating Beliefs In The Association Between Low Self¬-Esteem And Binge Eating Behaviours, Farah Al Mohammed
Theses
Research in the United Arab Emirates (UAE) around the causes and non-pharmacological treatment options of binge eating behaviours and other eating disorders is limited. Moreover, given the documented increase in binge eating behaviours which, in turn, is associated with two additional eating disorders (i.e., binge eating disorder and bulimia nervosa), there is an urgent need to understand the factors that are implicated in the causation and maintenance of binge eating behaviours in the UAE. A comprehensive understanding of these factors will assist psychotherapists and other mental health professionals in tailoring the interventions that they provide in the treatment and management …
Irritable Bowel Syndrome, Eating Disorders, And Mental Stress Among United Arab Emirates University Students, Maram Braikan Alotaibi
Irritable Bowel Syndrome, Eating Disorders, And Mental Stress Among United Arab Emirates University Students, Maram Braikan Alotaibi
Theses
Irritable Bowel Syndrome (IBS), Eating Disorders (EDs), and mental stress are understudied in the United Arab Emirates (UAE), especially among university students. The objective of this study is to assess the prevalence of IBS, ED, mental stress, their associations, and the determinants of IBS among United Arab Emirates University (UAEU) students. An observational cross-sectional study was conducted via a 48-item online-survey shared with 14,268 undergraduate/graduate students, registered during academic year 2021-2022 in UAEU. Logistic regression models were performed to examine the predictive factors associated with IBS among UAEU students in total and by ED status. Significance was determined at p< 0.05. The prevalence of IBS was 39%, ED 55.9%, and high mental stress 53.2%, and they co-existed in 15.9% of UAEU students. Students who reported consuming trigger-food were 6 times more likely to have IBS than their counterpart [AOR: 5.859; 95% CI: 3.092–11.102, p< 0.001]. Those who reported intakes of relief-food were 4 times more likely to have IBS compared to their counterpart [AOR: 3.881; 95% CI: 1.669 – 9.022, p=0.002]. Students with family history of IBS (FHIBS) were 2.6 times more likely to have IBS than their counterpart [AOR: 2.572; 95% CI: 1.420–4.660, p= 0.002]. Students with high mental stress were 1.7 times more likely to have IBS than those with low-moderate stress, when adjusted for sex and age [AOR:1.730; 1.058–2.830, p= 0.029). No significant associations existed between IBS and ED, Socioeconomic Characteristics (SEC), lifestyle, dietary, and health-related factors. UAEU students reported high prevalence of IBS, ED and mental stress. A significant relationship was found between IBS and FH-IBS, trigger- and relieving- food. This study confirmed the prevalence of IBS, ED and mental stress. Large cohort studies on university students in the UAE are warranted to establish the relationships among IBS, ED, mental stress and their determinants.
Exploring The Relationship And Impact Of Islamic Religious Coping On The Meaning Made Following The Loss Of A Loved One, Yara Ihab Am Ali
Exploring The Relationship And Impact Of Islamic Religious Coping On The Meaning Made Following The Loss Of A Loved One, Yara Ihab Am Ali
Theses
Coping after a loss of a loved one can play out differently for different individuals. The existing literature examines coping with loss and bereavement, but it is often with specific types of loss, and usually with western populations or religions. This paper examines the impact of Islamic religious coping onto the meaning made (integration of stressful event) following the loss of a loved one to death, in a diverse ethnic background sample population of various Muslims who have experienced loss in the past 5 years. The study focuses specifically on positive religious coping, and whether it would have a positive …
Psychosocial Predictors Of Cosmetic Surgery Acceptance Among Young Adult Women In The Uae. The Role Of Selfie Behavior, Narcissism And Religiosity: A Cross-Sectional Study, Amna Ahmad Alsadani
Psychosocial Predictors Of Cosmetic Surgery Acceptance Among Young Adult Women In The Uae. The Role Of Selfie Behavior, Narcissism And Religiosity: A Cross-Sectional Study, Amna Ahmad Alsadani
Theses
Cosmetic surgery is prevalent in the UAE and has been linked to negative psychological and physical consequences. The present study investigates psychosocial factors expected to predict an acceptance of cosmetic surgery among young adult women in the UAE. It was hypothesized that high selfie behavior, high narcissism, and low levels of religiosity would have a positive association with an interest in cosmetic surgery. The factors that motivate people to undergo cosmetic surgery were assessed using the 15-item Acceptance of Cosmetic Surgery Scale. Selfie behavior was examined using two questions derived from previous research. Narcissism was assessed using the 16-item Narcissistic …
Risk Factors For Eating Disorders Among Uae University Students: The Role Of Family Dysfunction And Attachment Styles, Aya Jaber Dandachi
Risk Factors For Eating Disorders Among Uae University Students: The Role Of Family Dysfunction And Attachment Styles, Aya Jaber Dandachi
Theses
A topic that is highly researched nowadays in the UAE is eating disorders (EDs). They are characterized by a persistent disturbance of eating-related behaviors that can result in altered consumption of food. Literature has suggested that there are several factors that can make an individual vulnerable to EDs, including family dynamics and attachment styles. This thesis is an attempt to examine the impact of family dynamics and early attachment on mental health wellbeing. The main objective is to examine how family dysfunctional concepts (rigid, chaotic, enmeshed, and disengaged) and attachment styles (close, dependent, and anxious) can be potential risk factors …
Investigation And Analysis Of Circular Economy Indicators In The Manufacturing Industry, Dina Al Jamal
Investigation And Analysis Of Circular Economy Indicators In The Manufacturing Industry, Dina Al Jamal
Theses
In the pursuit of sustainable development, the concept of the Circular Economy (CE) has emerged as a compelling and transformative alternative to the traditional linear economic model (i.e., take, make, use, dispose). The limitations of the linear economy in addressing contemporary global challenges have highlighted the urgency of adopting a more regenerative approach. Simply put, the circular economy aims to maximize the value extracted from available resources over their lifecycle, thereby ensuring the fulfillment of both current and future generations' needs. This thesis sheds light on a pivotal solution for effectively integrating circular economy principles into enterprises, thereby reinforcing sustainability. …
Human Error Assessment In Software Engineering, Benjamin S. Meyers
Human Error Assessment In Software Engineering, Benjamin S. Meyers
Theses
Software engineers work under strict constraints, balancing a complex, multi-phase development process on top of user support and professional development. Despite their best efforts, software engineers experience human errors, which manifest as software defects. While some defects are simple bugs, others can be costly security vulnerabilities. Practices such as defect tracking and vulnerability disclosure help software engineers reflect on the outcomes of their human errors (i.e. software failures), and even the faults that led to those failures, but not the underlying human behaviors. While human error theory from psychology research has been studied and applied to medical, industrial, and aviation …
Gender And Sociodemographic Discrepancies In Adhd Symptom Endorsement, Tabish Gul
Gender And Sociodemographic Discrepancies In Adhd Symptom Endorsement, Tabish Gul
Theses
Historically, the prevalence of attention deficit hyperactivity disorder (ADHD) has been found to be higher in men than women. However, recent work suggests that part of this discrepancy might be because ADHD may manifest in women in less disruptive ways and therefore be underdiagnosed. This issue is compounded by the fact that some ADHD traits may seem more “normative” at certain ages. To further understand potential biases in parent perception of ADHD symptoms, this study examines parent endorsement of the 18 DSM-5 criteria for ADHD cross-sectionally in a non-clinical sample of children from 3.3 to 6 years of age. It …
Impact Of Digital Transformation On Achieving Sustainability In Utility Sector Of Uae, Abdulrahman Salem Alsaleh
Impact Of Digital Transformation On Achieving Sustainability In Utility Sector Of Uae, Abdulrahman Salem Alsaleh
Theses
The central focus of the current study is to understand the impact of digital technology on sustainable practices in a utility sector within the UAE. The research examined whether AI, blockchain, and big data can improve sustainability in the company to completely understand how digital technologies influences sustainable practices in the county’s utility sector. Data were gathered using the survey data collection method for a quantitative review. The reliability of the data was examined using Cronbach’s Alpha, and the strength of the relationships between the variables was investigated using correlation analysis. The extent to which the adoption of AI, big …
How Will The Future Of The Dubai Virtual Commercial City Reshape The Policing Sector?, Shamma Ghanimi Mohammad Al Marri
How Will The Future Of The Dubai Virtual Commercial City Reshape The Policing Sector?, Shamma Ghanimi Mohammad Al Marri
Theses
The uncertainty of lack of policing involvement increases the worries and concerns and lack of trust of the potential virtual residents of Dubai Virtual Commercial City. The purpose of this research is to mitigate and minimize virtual crimes and expand safety and security in the virtual world. Using various future foresight tools to bring new solutions and recommendations to support law enforcement to ensure proactive policing in the virtual world. The results of the study show a clear correlation between the lack of rules and regulations and new emerging virtual crimes. Moreover, it also showcases the recent international effort by …
Modifying Attention Away From Food Cues: The Utility Of Attentional Bias Modification Training Among Emotional Eaters, Moet Aita
Theses
The current study (N=153) was designed to explore the relationships between emotional eating and emotion regulation, attentional biases, and food consumption. Emotional eating describes the tendency to eat in response to emotional experiences, especially negative emotions, and is associated with the consumption of high-fat, sugary foods. The present study explored whether food intake could be modified among a sample of emotional and non-emotional eaters by shifting attention away from high-calorie pictorial food stimuli using the attentional bias modification (ABM) training paradigm. Participants were randomly assigned to either the attentional-training group, placebo-training group, or control group. Following the training, participants underwent …
Deaf Communication Awareness, Emily Grace Cruz Amponin
Deaf Communication Awareness, Emily Grace Cruz Amponin
Theses
Whenever a Deaf or Hard-of-Hearing person or a group of deaf people converse with people who aren’t deaf, they know various communication approaches such as writing notes on paper or phones, basic gestures, talking clearly, or lip reading if they grew up with an oral method. A Deaf or Hard-of-Hearing person may have hearing devices: hearing aids or cochlear implants, or they have none of these hearing devices. The Deaf and Hard-of-Hearing people are trying and willing to communicate with their relatives, employees, customers, classmates, or instructors. However, people do not look at a Deaf or Hard-of-Hearing person or a …
Generative Artificial Intelligence Program And Service: Imaginex, Mengheng Xu
Generative Artificial Intelligence Program And Service: Imaginex, Mengheng Xu
Theses
The idea to facilitate the creation of personal spaces that afford privacy, comfort, and autonomy to individuals in need seems to be especially significant while availability and affordability of physical spaces are constrained. This project proposes a system called ImagineX which is a generative artificial intelligence program and service that can generate virtual 3D spaces for users. Users can create customized 3D environments tailored to their specific needs and preferences simply by inputting word prompts. By connecting the program from a tablet to a virtual reality (VR) system, users can experience and interact with these virtual spaces in an immersive …
Addendum To Ap Art History Curriculum: Impressionism And Its Female Painters, Julie Short
Addendum To Ap Art History Curriculum: Impressionism And Its Female Painters, Julie Short
Theses
This project seeks to add depth to Content Area 4 of the AP Art History Curriculum by supplementing the study of Impressionism as a whole, as well as including the study of the role of women artists in the movement and their contributions to Impressionism and Modern art in general. The goal is to provide students with greater historical context and formal analysis of major Impressionist works, as well as to expose students to the accomplishments of more female artists.
Optimized Generative Pre-Training Eeg To Sentiment Classification (Ogptsc), Amira Hassan
Optimized Generative Pre-Training Eeg To Sentiment Classification (Ogptsc), Amira Hassan
Theses
This research aims to revolutionize electroencephalogram (EEG) analysis by proposing and developing an innovative method for sentiment classification, introducing the groundbreaking "Optimized Chat Generative Pre-training EEG to Sentiment Classification (OGPTSC)." This novel approach harnesses the power of Generative Pre-training (GPT2) as the vocabulary language model while utilizing an intelligent hyper-parameter selection method to fine-tune and optimize the model's performance. Extensive testing is conducted on a widely recognized dataset to evaluate the OGPTSC's prowess, demonstrating its exceptional capabilities in sentiment classification. Notably, this research extends its scrutiny beyond the OGPTSC by applying the same hyper-parameter selection technique to well-established models such …
The Future Of Deep Fakes: Analyzing The Potential Future Consequences Of The Widespread Use Of Deepfakes On The Policing Sector, Maryam Salem Alshamsi
The Future Of Deep Fakes: Analyzing The Potential Future Consequences Of The Widespread Use Of Deepfakes On The Policing Sector, Maryam Salem Alshamsi
Theses
In today’s world there is a growing uncertainty in terms of the truthfulness of what we see and hear. People digest a great amount of information throughout the day using their devices, yet the quality and credibility of content is in question. People question if we are experiencing and perceiving the same reality at this point. This issue is not novel, however, it has progressed and developed to a level of realism that deceives people and affect their comprehension of information. Rapid technological advancement has raised the concern of what is referred to as “Deepfakes”, a machine learning technique that …
Comparing Various Staff Training Modalities Within Applied Behavior Analysis, Jason Joseph Starr
Comparing Various Staff Training Modalities Within Applied Behavior Analysis, Jason Joseph Starr
Theses
Behavioral skills training (BST) has continuously demonstrated to be an effective means of training others in new skills and techniques. A limitation of BST, however, is that it requires extensive time and a professional trainer. Currently, there is a lack of literature comparing BST to alternative and effective training methods that require less resources, such as written directions and video modeling. Therefore, the purpose of this study was to determine which training modality (i.e., behavior skills training, written directions, or video modeling) was most effective at increasing staff members' correct implementation of applied behavior analysis procedures, specifically forward chaining, shaping, …
Amulet: Addressing Emotional Abuse, Wentao Sun
Amulet: Addressing Emotional Abuse, Wentao Sun
Theses
In a world grappling with the scourge of psychological violence, particularly gaslighting, in intimate relationships, the "Amulet" project presents a visionary design solution. Positioned at the intersection of emotional abuse and technology, the project conceptualizes Amulet as a biometric system embodied in a hypothetical skin tattoo and extendable across digital devices. The Amulet project explores the potential role of design in challenging and addressing this insidious form of abuse. The core elements of the project include designing a unique brand identity for Amulet and the creation of a user-friendly interface that offers an intuitive and empowering user experience. The designed …
Artificial Games, Jake Johnson
Artificial Games, Jake Johnson
Theses
This thesis project is an attempt to create an integration of augmented reality (AR) technology and tabletop board games, with a focus on tackling the challenge of maintaining engagement and capturing the attention of modern audiences who are often drawn to more interactive forms of entertainment like movies and video games. Specifically, the project explores the concept of augmenting older tabletop games with a combination of futuristic digital graphics and overlays with original physical game elements. The project sees and recognizes the problem, which is that the disparity between the level of engagement offered by traditional tabletop games and the …
Outness Among Transgender And Non-Binary Adults: Effects Of Identity And Agency On Mental Health, Beau M. Gibbs
Outness Among Transgender And Non-Binary Adults: Effects Of Identity And Agency On Mental Health, Beau M. Gibbs
Theses
The present study investigated binary transgender (BT) and non-binary (NB) individuals both as an entire transgender non-binary (TNB) group and as two separate groups to examine entire group mental health trends and discern differences in mental health problems between groups. Outness, agency, experiences of transgender identity based microaggressions, and internalized transphobia in particular were investigated in relation to mental health. This study was conducted via an online survey and included 34 BT participants and 58 NB participants (92 participants in total). The correlation matrices and ANCOVAs revealed that none of the study hypotheses were supported. However, it was found that …
The Implications Of Venus In The Interwar Oeuvre Of James Guy, Emily Cooper
The Implications Of Venus In The Interwar Oeuvre Of James Guy, Emily Cooper
Theses
American Social Surrealist James Guy was a Communist proletarian artist who created works of art that depicted the social inequities he witnessed and experienced during the Great Depression. As a working-class artist, Guy painted images of daily life with recognizable and accessible iconography that allowed his fellow manual laborers to relate to the depicted scene. Guy distorted commonplace experiences through the filter of Surrealism to create absurd, illogical, and nightmarish environments to critique contemporary society. Guy worked to spark the realization of the viewer that they were subjected to the same injustices as the figures in his paintings. In this …
Stacking The Deck In The Learner's Favor: Behavioral Skills Training Improves Safmeds Implementation, Lauren Olsen
Stacking The Deck In The Learner's Favor: Behavioral Skills Training Improves Safmeds Implementation, Lauren Olsen
Theses
“Say All Fast Minute Every Day Shuffled” (SAFMEDS) is a structured, evidence-based protocol for using flashcards. The protocol is a sequence of steps that are designed to promote accurate and quick responding to learn the information presented on flashcards. Although the benefits of using SAFMEDS have been well-documented, much of the literature fails to adequately describe the methods used to train participants on how to use the protocol. In addition, few studies measure participant procedural integrity (i.e., the extent to which the protocol is implemented as planned). To date, no study has systematically examined the effects of different training methods …
An Evolutionary Comparative Study Of Congenital Stationary Night Blindness-Associated Trpm1 Genetic Variants Of Uncertain Significance In Horses And Humans Utilizing Caenorhabditis Elegans, Gabrielle Davis
Theses
Congenital stationary night blindness (CSNB) is a heterogeneous collection of genetic diseases affecting the eyes and vision in horses and humans. Current research has implicated several genetic mutations impacting different genes involved in phototransduction and signal transmission, including TRPM1. In horses, genetic mutations in TRPM1 also result in a leopard spotting pattern or leopard complex. The goal of this study is to examine the potential impact of CSNB associated TRPM1 missense variants of uncertain significance (VUS). Previous research in Caenorhabditis elegans have revealed an orthologous TRPM1 gene known as gon-2 that allows for comparative studies. The evolutionary relationship of …