Digital Commons Network^™

Osha Laboratory Safety Standard 29 Cfr 1910.1450 And Achieving Compliance In The Microelectronic Laboratory, Danielle M. Digironimo

Theses

This thesis is a practical application of occupational exposures to hazardous substances in a microelectronics laboratory. The Occupational Safety and Health Administration (OSHA) standard for the safety in laboratories is (29 CFR 1910.1450). The application is a demonstration of the implementation of the standard in a university setting. Hazards that exist in laboratory settings are very complex and the task of providing a safe workplace can become increasingly complicated. A laboratory can and does impose different health and safety concerns that a standard industrial workplace setting might not have. The need for a laboratory safety standard program to be implemented …

Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold

Theses

Electrospinning processes apply electric fields to a polymer solution in order to produce strands of polymer in the nanoscale range. These polymer fibers are manipulated for their porosity, high surface area, fineness and uniformity. In order to create the ideal drug delivery system for intracranial arteriovenous malformations (AVMs) and tumors, D, L poly-(lactice-poly-glycolide) (DLPLGA) nanofibers were electrospun in a tetrahydrofuran (THF) solvent. Three different concentration ratios of DLPLGA, 85/15, 80/20, and 75/25 were analyzed to obtain the prime base for drug annexation. 1 ,3-bis (2-chloroethyl)- 1 -nitrosourea (BCNU) was then codissolved with the DLPLGA nanofibers to form a homogenous solution, …

Supply Chain Risk Analysis, Venkata R. Kallepalli

Theses

A new decision support system is proposed and developed that will help sustaining business in a high-risk business environment. The system is developed as a web application to better integrate the supply chain entities and to provide a common platform for performing risk analysis in a supply chain. The system performs a risk analysis and calculates risk factor with each activity in the supply considering its interrelationship with other activities. Bayesian networks along with fault tree structures are embedded in the system and logical rules are used to perform a qualitative fault tree analysis, as the data required to calculate …

Analysis Of Auf1 Targeted Mrna Sequences, Jiebo Lu

Theses

AUF 1, an A+U rich element (ARE) binding protein, plays an important role in mRNA decay. To identify the mRNAs that interact with AUF 1, mRNA derived from a human cardiac cDNA expression library was purified by AUF 1 affinity chromatography and cloned following RT-PCR. 261 sequences were obtained. The sequences were searched against two protein databases and four nucleic acid databases, and the sequence information and database search results were input into a local Microsoft Access database, BLAST-AUF 1, by Java applets for parsing document. Analysis of protein information by querying BLAST-AUF 1 identified 194 function-known proteins, which were …

An Investigation Of Position And Force During Gait-Mimicking Finger Motions, Matthew Stephen Noesner

Theses

Spinal cord injuries are extremely debilitating, often leaving the injured person without the ability to use their legs (paraplegia) and sometimes, without the ability to use their arms and legs (tetraplegia or quadriplegia). Currently, primitive forms of feed-forward functional electrical stimulation (FES) and special orthotics are available for persons with paraplegia. However, these forms of FES do not allow the individual to actually control their movements on a real-time basis, nor do they offer the ability for the injured person to sense the ground on which they stand.

It is the goal of the researchers at the Neuromuscular Engineering Laboratory, …

Supply Chain Risk Mitigation, Roshan R. Pai

Theses

In recent years, especially post 9/11, there has been an increasing awareness for securing business supply chains against probable disruptions. With globalization and lean inventories, the efficiency of supply chain has greatly enhanced over the years, but at the expense of new vulnerabilities. Supply chain vulnerabilities have resulted in disruptions to the economic stability and security. As a result, risk analysis and mitigation has now grown to become one of the key links to business stabilization. To ensure business continuity, it is necessary to identify key assets (physical and operational) within the supply chain and secure them against probable threats. …

Voice Onset Time Variation In Stop Consonant To Vowel Transitions, Abhishek Gunvant Parikh

Theses

Reduced duration, increased consistency, and improved intelligibility are goals of reducing the motor complexity of speech for individuals with cerebral palsy having dysarthria. In this study, measurement and analysis were made to compare an individual with spastic Cerebral Palsy (CP) having dysarthria to an individual with athetoid CP having dysarthria as well as to a non-dysarthric individual. Each participant's normal speech, whispering, and speech using an artificial larynx was evaluated, utilizing the source-filter theory methodology. The plausibility of dysarthric speech duration reduction by minimizing vocalization is tested by stop consonant "P,, to vowel transitions. The data suggest that speech duration …

Extrusion And Evaluation Of Degradation Rate And Porosity Of Small Diameter Collagen Tubes, Bipinkumar G. Patel

Theses

The limited availability of autografts and failure of small diameter synthetic vascular grafts has stimulated continuing efforts to develop small diameter vascular grafts based on natural materials. The small diameter collagen tubes were extruded using bovine collagen type I. The biodegradation rate was determined and compared for small diameter collagen tubes crosslinked with glutaraldehyde and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and Nhydroxysuccinimide (NHS) to evaluate physio-chemical properties. The samples were also evaluated for their surface area and porosity using mercury porosimeter. The noncrosslinked tubes almost completely degraded after 2 hours. The tubes crosslinked with EDC/NHS degraded slower than the ones crosslinked with …

Mathematical Modeling Of Transient State Transdermal Drug Delivery, Alison Nickol Weltner

Theses

In this work, a two-pathway mathematical model for transdermal drug delivery with iontophoresis is presented. The partial differential equations are described and then solved. An alternative, two-pathway, three-layer model is also presented, and the implications of the coefficients within the equation are discussed. Using Franz cell iontophoretic delivery data from three drug substances (amitriptyline HCl, clomipramine HCl, and nortriptyline HCl), the two-pathway model is regressed to determine the diffusion coefficient and the concentration within the skin at the drug reservoir interface. ANOVA analysis indicates a correlation between iontophoretic current and concentration of drug within the stratum corneum.

An Ergonomic Assessment Of The Airline Baggage Handler, Stephen P. Salomon

Theses

A material or baggage handler is responsible for loading and unloading baggage and materials from inbound/outbound aircraft flights and transferring the materials to and from the baggage holding and sorting areas and back to the passengers or output source. Baggage handlers work in all types of inclement weather, all over the airport, and in-and-around the aircraft. The baggage handler's job entails repeated lifting pulling, pushing, squatting, twisting, kneeling, and stretching of the arms and back, which makes the baggage handler's job one of the more challenging material handling jobs to ergonomically assess and make corrections for. The aim of the …

Analysis Of Molecular Conformations Using Relative Planes, Deepa S. Pai

Theses

Ring substructures of a drug usually participate actively in binding to the receptor. It is necessary to study the spatial relationship of these molecular recognition features in order to determine the pharmacophore of the drug. This is a particularly difficult problem when the drug is a flexible molecule with many energetically accessible conformations.

In this research an innovative approach to calculate the relative displacement and orientation of every possible pair of rings in a given molecule was designed, tested, and implemented in the "Planes" program. Planes were defined from each of the ring substructures and the displacement and rotation of …

Random Search Conformational Analysis Of Piperazine And Piperadine Analogs Of Gbr12909 : Implicit Aqueous Solvation Effects, William A. Roosma

Theses

The object of this work was to study the effect of solvent on the conformational potential energy surface (PES) of GBR12909 analogs. Local minima on the PES's were found by the Random Search algorithm using the Sybyl molecular modeling package from Tripos, Inc., and an implicit solvent model. Two force-field/charge models were employed in the analysis: the Tripos force field with Gasteiger-Huckel charges and the MMFF94 force field with MMFF94 charges.

The effect of solvent on the location of minima in multi-dimensional torsional angle space was studied by comparison to the vacuum phase results. Minima were plotted in torsional angle …

Persuasion By Association: A Content Analysis Of Cigarette Advertisements Aimed At The Youth Market, Pamela L. Carmichael

Theses

Past research suggests that manufacturers market cigarettes through advertisements associating cigarettes with qualities and behaviors valued by the target audience. Using content analysis, the present study compares the visual and verbal/textual product associations in cigarette advertisements in youth- (People and Sports Illustrated) and adult-oriented (Time and Better Homes and Gardens) magazines. Results show significant differences in product association categories, with ads in youth magazines significantly more likely than those in adult magazines to employ associations related to social gatherings/friendship, romance/eroticism, independence/self-reliance/rebellion, prize giveaways/merchandise, and pleasure/refreshment/flavor/quality. This study adds to the body of knowledge on the content of cigarette advertisements and …

What Educators Must Know About The Effectiveness Of Behavioral Interventions For Children With Autism, Renee' L. Henke

Theses

The diagnosis of autism is on the rise. There are many misconceived definitions of autism, even in the educational profession. Educators in all areas must become informed of behavioral intervention and modifications to help autistic students succeed.

This paper will reveal facts and information regarding behavior intervention and modification based on the Lovaas theory and method. It includes a case study of an eleveny-ear- old high-functioning autistic boy who has made great strides and is successful.

Environmental Risk Factors Of Bronchial Asthma Among Primary Schoolchildren In Abu Dhabi City, Fareed Hussain Saleh H. Jalabi

Theses

The aim of this study was to describe the current epidemiological pattern of bronchial asthma among the schoolchildren aged 7-12 years old in 60 government primary schools at Abu Dhabi city -UAE.

The analytical cross-section design (ACSD) was chosen as a suitable method to investigate the exposure variables (environmental risk factors) and prevalence of bronchial asthma simultaneously in a representative samples.

A self-administered questionnaire was completed by the parents of the school children to collect information regarding bronchial asthma, other related allergic conditions and family history of respiratory allergy.

Analyses of the effect of the different socio-demographic variables and clinical …

Opposite Effects Of Lithium And Valproic Acid On Trophic Deprivation-Induced Gsk-3(Beta) Activation, C-Jun Expression And Neuronal Cell Death, Ning Jin

Theses

Recent studies demonstrate that lithium and valproic acid (VPA), two commonly used mood-stabilizing drugs, have neuroprotective effects against a variety of insults. Inhibition of the pro-apoptotic enzyme, glycogen synthase kinase-3P (GSK-3P), was suggested to be the mechanism of action of neuroprotection for both drugs. In this study, we tested if lithium and VPA could protect cultured cerebellar granule neurons (CGNs) from GSK-3P-mediated apoptosis induced by trophic withdrawal (serum/potassium deprivation). Lithium concentration-dependently (1-20 mM) protected CGNs. Indirubin, a specific, direct GSK-3P inhibitor, was also neuroprotective. On the contrary, VPA (1- 20 mM) did not provide any neuroprotection and even potentiated cell …

Development Of Fmri Compatible Lower Body Negative Pressure System, Pratap Singh Kunwar

Theses

The lower body negative pressure (LBNP) system provides a controlled, measured orthostatic stress to the cardiovascular system, which can be used with a magnetic resonance imaging (MRI) machine to study cardiovascular and cerebrovascular responses to graded LBNP. In the past, even though functional MRI (fMRI) was considered as one of the best modalities with which to measure small metabolic changes in the brain, it has not been used with an LBNP system to measure cerebrovascular changes. This was due to the lack of an fMRI compatible LBNP system.

In this project, an tMRI compatible LBNP system was first constructed without …

Modeling And Analysis Of Hospital Facility Layout Problem, Amol Shrikrishna Padgaonkar

Theses

The optimal solution to any facility layout problem is an important aspect and a major concem as it involves significant material handling and transportation cost. The objective is to arrange the departments within the predefined facility boundaries in the way that the interaction between the functions is efficient and the overall movement cost is minimized. While facility layout problems have traditionally focused on manufacturing facilities, there has been little work on analyzing layouts for hospitals. The thesis focuses on hospital facility layout problems (HLP) to (i) minimize the movements of patients and (ii) minimize the movements of accompanying resources such …

Patient Handling Ergonomics, Paul Reichert

Theses

The incidence of musculoskeletal injuries among healthcare workers has been well documented in the medical and ergonomic literature. The epidemiological evidence demonstrates high injury rate among nurses, nurse's aides, therapists and other medical workers who frequently handle patients. The biomechanical research has shown large compressive forces developed in the lumbar spine performing various patient handling transfers that exceed the National Institute of Occupational Safety and Health's recommended guideline. One of the most strenuous patient handling tasks is transferring the patient from bed to the chair and vice versa.

One of the objectives of this thesis is to design and conduct …

Transmission Of Light And Audible Sound In A Synthetic Fog Medium, Bhavin Babaria

Theses

The primary goal of the thesis was to study the propagation of visible light and auditory sound through a synthetic fog medium compared to an ambient air environment. It is known that the fog substantially decreases the visibility however; this has not been studied quantitatively. Further information regarding other energies such as sound is also needed to understand how the energy reacts in the fog medium. The extent of visual and auditory degradation in humans needs to be investigated. Researchers have studied light transmitted through water, air; however, no one has studied how light or sound is transmitted through a …

Evaluation Of Postural Stability Using Sensory Organization Test, Tiffany Sims

Theses

Poor postural stability of the elderly and other patients has been a major concern.The cost of treating injuries due to poor stability is expected to rise to $32.4 Billion by 2020. Many interventions have been proposed and used to improve stability. In order to determine the efficacy of these interventions, an objective evaluation of postural stability before and after intervention is important.

The aim of this thesis was to scientifically analyze the ambiguities in the equilibrium score (ES) given by the Neurocom Smart Equitest (NSE) machine, and compare it to a new measure of stability that has been proposed by …

Investigation Of Heart Rate Variability During Sleep Apnea, Sekar Subramanian

Theses

Sleep apnea is a disorder, where there are repetitive pauses in respiratory flow of at least 10 seconds or longer duration, and which occur more than five times per hour. Apnea has strong modulating effects on the autonomic nervous system, with prominent heart rate variation. It can be assumed that during sleep, internal influences (sympathetic and parasympathetic nervous system activities) dominate the autonomic nervous system; in addition repetitive apneas are accompanied by a pronounced increase in average heart rate. The aim of this study was to investigate the heart rate variability using spectral analysis and time-frequency analysis during sleep apnea. …

Wavelet Transform Methods For Identifying Onset Of Semg Activity, Janina Wilen

Theses

Quantifying improvements in motor control is predicated on the accurate identification of the onset of surface electromyograpic (sEMG) activity. Applying methods from wavelet theory developed in the past decade to digitized signals, a robust algorithm has been designed for use with sEMG collected during reaching tasks executed with the less-affected arm of stroke patients. The method applied both Discretized Continuous Wavelet Transforms (CWT) and Discrete Wavelet Transforms (DWT) for event detection and no-lag filtering, respectively. Input parameters were extracted from the assessed signals.

The onset times found in the sEMG signals using the wavelet method were compared with physiological instants …

Speech Enabled E-Learning Technology For Adult Literacy Tutoring, Jason Meade

Theses

This research presents the work involved in developing a speech-enabled e-Learning prototype for use in literacy tutoring. As the main objective was to develop an interface for literacy learning, initial research concentrated on establishing a framework for literacy e-Leaming through the use of speech technology. Requirements for best practice e-Learning and the relevance of learning theories to an e-Learning application were also investigated. The technologies to facilitate this, such as text to speech technologies and mark-up languages, were addressed during the implementation of speech-enabled prototypes. Both server-side and client-side prototypes were implemented to investigate speech technology. Testing found the server-side …

Data Limitations Can Be Overcome To Move Toward Effective Business System Integration, Paul G. Ruganis

Theses

Investigation indicates that data quality and consistency issues will continue to be overwhelming impediments to the complete integration of all information systems in the current Information Technology (IT) environment. However, there is evidence that businesses can still move toward an effective "Digital Business Design" (DBD) by focusing on a relatively small number of critical success factors. The possible approaches to integration available in the current IT environment were reviewed to gain insight into candidate design bases available. The DBD implementations of sample firms were examined to explore what aspects of integration they considered in their implementations and whether or not …

The Mapping Of Velocity Profiles In A Three Generation Lung Model Using Particle Image Velocimetry Flow Analysis Techniques, Adam D. Pruyne

Theses

The intent of this thesis was to develop an understanding for the particle flow characteristics in the human lung by examining particle flow profiles in a three generation lung model. To develop this understanding, experimentally derived flow profiles were compared to analytical solutions, where applicable, and Computational Fluid Dynamics (CFD) generated models for validation of both the CFD model and the experimental set-up. Validation of flow velocities in a three generation model could contribute significantly to the medical industry as a better understanding of particle behavior in the lung could lead to more accurate treatment of certain diseases and better …

Environmental Assistance For Small Businesses: Best Practices For Maximization Of Small Business Participation In State Funded Environmental Compliance Programs, Gulya Kolakova

Theses

Small businesses face many challenges as they strive toward growth and profitability. Adding to this challenge is the demand for improved environmental performance. Pollution prevention is often the most cost effective way to improve environmental performance. Yet, small firms often lack the expertise they need to pursue pollution prevention opportunities. There are a number of state agencies in New York that provide assistance and funding to small businesses to implement pollution prevention strategies. They often work in collaboration with nonprofit organizations that provide on-site technical assistance and consultancy to small businesses. It is up to the small business management to …

Cyclic Olefin Copolymer (Coc) In The Pharmaceutical Industry, Amgad Khalil

Theses

The purpose of this research was to evaluate an alternative to polyvinyl chloride based packaging materials for pharmaceutical blister packaging that is neither harmful to the environment nor corrosive to the equipment used in pharmaceutical packaging. Olefin structures (PP/COC/PP) were tested and compared to halogen based material (PVC/PVDC) using the following criteria: • Moisture Vapor Transmission Rate (MVTR) • Vacuum leak test • Peel strength test • Machine ability and form-ability on an Uhlmann UPS4 thermoformer • Layer distribution • Financial impact Cyclic Olefin Copolymers (COC) was proven to have the properties required to adequately protect the product while being …

High-Resolution, Slant-Angle Scene Generation And Validation Of Concealed Targets In Dirsig, Kris E. Barcomb

Theses

Traditionally, synthetic imagery has been constructed to simulate images captured with low resolution, nadir-viewing sensors. Advances in sensor design have driven a need to simulate scenes not only at higher resolutions but also from oblique view angles. The primary efforts of this research include: real image capture, scene construction and modeling, and validation of the synthetic imagery in the reflective portion of the spectrum. High resolution imagery was collected of an area named MicroScene at the Rochester Institute of Technology using the Chester F. Carlson Center for Imaging Science's MISI and WASP sensors using an oblique view angle. Three Humvees, …

Address Assignment In Ad-Hoc Networks, John Paul O'Grady

Theses

A wireless ad-hoc network is a collection of autonomous nodes or terminals that communicate with each other by forming a multi-hop radio network and maintaining connectivity in a decentralised manner. In an ad hoc network routing is used to find and maintain a path through the network. Routing requires each node to have a unique identifier, to ensure that packets sent to a particular node reach their intended destination. Most ad-hoc routing protocols assume that a node already has an address prior to its entry into a network and so the issue of address assignment is largely ignored. This however …