Digital Commons Network^™

Anti-Metastatic And Anti-Tumor Growth Effects Of Carnosol On Breast Cancer, Halima Ali Mohammed Salem Al Samri

Theses

Our lab has previously showed that carnosol, a naturally occurring polyphenol, exhibits anti-cancer activity by promoting cell cycle arrest at G2 phase, and induces reactive oxygen species (ROS) dependent apoptosis and beclin-1 independent autophagy in triple negative breast cancer (TNBC) cell line (MDA-MB-231). Here, we extended our study by investigating the potential effect of carnosol on migration, invasion and tumor growth of these cells. Our findings demonstrated that carnosol, at non-cytotoxic concentrations, exerted a potent anti-metastatic and anti-tumor growth activity against the highly invasive TNBC cell line, MBA-MB-231. Carnosol inhibited the migration and invasion of MDA-MB-231 cells. Moreover, carnosol suppressed …

Anticonvulsant And Procognitive Properties Of Novel Histamine H3 Receptor Antagonists In Male Adult Rats, Ali Kassem Saad

Theses

To determine the potential of histamine H3 receptor (H3R) ligands as new antiepileptic and procognitive drugs, aromatic ether derivatives (1-12) belonging to the nonimidazole class of ligands, with high in-vitro binding affinity at human H3R, were tested for their in-vivo anticonvulsive activity in maximal electroshock (MES)-, pentylenetetrazole (PTZ)-, and strychnine (STR)-induced seizure models in male adult rats having phenytoin (PHT) and valproic acid (VPA) as the reference antiepileptic drugs, pitolisant (PIT) as the standard H3R antagonist/inverse agonist, and donepezil (DOZ) as a reference procognitive drug. Among the H3R ligands (1-12) tested in the current project, H3R …

English Teachers' Perceptions Toward The Effectiveness Of Using Communicative Language Teaching (Clt) In Teaching Grammar At Al Ain Public Schools, Ahmad Salamah Issa Bani Taha

Theses

This study investigates English teachers' perceptions toward the effectiveness of

using Communicative Language Teaching (CLT) in teaching grammar at Al Ain

public schools. This study was conducted using a questionnaire to collect the

required data from the participants (n=180) regarding their perceptions toward the effectiveness of using CLT in teaching grammar. The results of this study revealed that English teachers at Al Ain public schools perceived CLT as an effective approach in teaching grammar (m= 3.83). The results have also shown that the participants prefer using communicative activities in teaching grammar when using CLT (m=3.69). As for the challenges, the …

Finite Semifields And Their Applications, Shamsa Ali Rashed Al Saedi

Theses

This thesis is concerned with finite semi fields. The objective of this thesis is to give a full description of Knuth orbits of known commutative semi fields. We also describe planar functions corresponding to commutative semi fields. Results are presented by tables. Nuclei of semi fields are studied. Finally we consider applications of semi fields, planar functions and spreads to construction of mutually unbiased bases.

Thermal Analysis For The Purpose Of Fault Diagnosis Of Commercial Proton Exchange Membrane Fuel Cells (Pemfc), Reem Izzeldin Elsadig Salim

Theses

The world's awareness towards the amount of destruction that our extensive and ignorant lifestyles in the past few decades have imposed on the environment is growing day after day. This resulted in an increased governmental and research interest towards the development and use of green technology. Fuel Cells are one of the green technologies that received a major share of research interest in the past decade.

However, despite their promising features, Fuel Cell systems still lack a solid fault diagnosis and predictive maintenance study. There are numerous faults that have to be detected and diagnosed on a fuel cell power …

Biometrics-Based Dynamic Authentication For Secure Services, Saif Mohammed Saeed Abdulla Al Aryani

Theses

This thesis proposes a secure authentication protocol against physical session hijacking attacks. In client/server technology, users establish sessions to access the services offered by the servers. However, using physical session hijacking attacks, malicious users may physically take control of ongoing sessions. Malicious users also can establish sessions with servers using stolen passwords. In both cases, the server will be communicating with the wrong user who pretends to be the real user. The goal of this authentication protocol is to continuously and dynamically ensure that during an ongoing session the current session’s user is himself the real person that is known …

Study Of The Seasonal And Interannual Variability Of Phytoplankton Bloom In Arabian Gulf Using Modisdata, Malik Mutasim Malik Gasim

Theses

The Arabian Gulf is a semi enclosed large water body that experiences seasonal

variations and reversal of it water currents flow circulation. The Gulf waters are characterized by having high primary productivity and strong phytoplankton blooms at particular seasons within the year. Phytoplankton is a base of the food chain for marine species, providing an essential food resource for aquatic life. Marine phytoplankton affects the diversity of any marine ecosystem and drives its functioning and is strongly correlated with fishery yields. The primary

objectives of this research study are to answer key research questions related to phytoplankton blooms in the …

Condensed Living In Emergency Situations: Creating A Sense Of Comfort And Safety Through Design, Alexandra Bush

Theses

Condensed Living in Emergency Situations is a design based thesis that focuses on the amalgamation of comfort and safety through the design of a transportable disaster relief shelter. The “Unit” provides private and comfortable shelter to those displaced by a natural disaster, specifically in an urban setting. The concept for this thesis stems from the aftermath of Hurricane Sandy in 2012, and the recovery and rebuilding process that then took place. Recognizing the occurrence and the positivity of community comradery, this thesis design proposes a feasible solution to creating comfortable shelters for those displaced, while eliminating the need to relocate …

Sustainable Management Of Food Supply-Chain Resources In New York State, Jacqueline H. Ebner

Theses

A sustainable food supply chain (FSC) is at the nexus of several critical global challenges including hunger, resource scarcity, climate change, poverty, energy security and economic growth. However, managing FSC resources in a sustainable manner is complex and data to support this goal is lacking. This dissertation addressed four knowledge gaps by applying a variety of analytical and experimental tools to the New York State FSC.

First, a cradle-to-grave analysis of the New York State FSC was conducted. Resources leaving the FSC from primary production (post-harvest) through to consumption were defined and characterized. Surveys and literature were used to estimate …

Securing The Integrity Of The Power Distribution System For Smart Grid Applications, Hosam Yousef Hittini

Theses

The distribution system is one of the main components in a smart grid, readings are transferred from the distribution substations to the control center. Compromising transferred system data will result in drawing wrong conclusions about current operation status at the control center. Which leads to sending wrong operational commands that may result in very serious consequences.

Firstly, we propose a scalable communications architecture for future smart grid distribution systems (i.e. Security Aware Distribution System Architecture - SADSA). The architecture is adaptable to use Wi-Fi or other technologies to transfer smart grid information. The architecture is studied from various angles. Both …

Achievable Accuracy Of Radiation Dose Measurement For Linear Accelerators Using Different Protocols, Mariam Hamad Al Darmaki

Theses

The aim of radiotherapy treatment is to deliver a specified radiation dose throughout a definite target volume within predetermined levels of accuracy and homogeneity; at the same time ensuring adequate dose sparing of surrounding normal tissue. Radiotherapy is a complex process involving a number of steps and the accuracy of each stage has a direct impact on the treatment outcome. At each stage, comprehensive quality assurance procedures are required to ensure safe and accurate delivery of the prescribed dose.

This project will aim to determine the currently achievable accuracy and reproducibility of radiotherapy dosimetry and assess the current recommendations for …

Killing Two Birds With One Stone: The Concurrent Development Of The Novel Alignment Free Tree Building Method, Scrawkov-Phy, And The Extensible Phyloinformatics Utility, Emu-Phy., J. Nick Fisk

Theses

Many components of phylogenetic inference belong to the most computationally challenging and complex domain of problems. To further escalate the challenge, the genomics revolution has exponentially increased the amount of data available for analysis. This, combined with the foundational nature of phylogenetic analysis, has prompted the development of novel methods for managing and analyzing phylogenomic data, as well as improving or intelligently utilizing current ones. In this study, a novel alignment tree building algorithm using Quasi-Hidden Markov Models (QHMMs), Scrawkov-Phy, is introduced. Additionally, exploratory work in the design and implementation of an extensible phyloinformatics tool, EMU-Phy, is described. Lastly, features …

Combined Dynamic Thermal Management Exploiting Broadcast-Capable Wireless Network-On-Chip Architecture, Niraj Vasudevan

Theses

With the continuous scaling of device dimensions, the number of cores on a single die is constantly increasing. This integration of hundreds of cores on a single die leads to high power dissipation and thermal issues in modern Integrated Circuits (ICs). This causes problems related to reliability, timing violations and lifetime of electronic devices. Dynamic Thermal Management (DTM) techniques have emerged as potential solutions that mitigate the increasing temperatures on a die. However, considering the scaling of system sizes and the adoption of the Network-on-Chip (NoC) paradigm to serve as the interconnection fabric exacerbates the problem as both cores and …

Spirituality & Young Adults Work Performance, Kirstijan Hrdzic

Theses

Young adults are facing though time adapting to their workplace environment. This results with reduced work performance. In order to find intrinsic motivation for their work, practicing spirituality is one of the possible solutions. The purpose of this study was to investigate the relationship between spirituality and young adults’ work performance. A survey was administered online asking young working adults in the Zagreb area to complete a 37 items questionnaire. The first part of questionnaire contained items that tested perceived daily spirituality experience, while the second part of questionnaire contained items pertaining to task work performance, contextual work performance and …

Clearance Analysis Of 3d Printed Assemblies Using Fused Filament Extrusion, Kshitij Luthria

Theses

3D Printing technologies have been around for the better part of 30 years now, and researchers today have a reasonably good understanding of how the different processes work. A focus for the next era of 3D printing will likely be to gain a deeper understanding of how these processes can be used in unique applications. One such unique application that can potentially change the way conventional manufacturing works involves 3D printing of assemblies. By printing assemblies ‘in-situ’, multiple assembly steps can be by-passed, thus increasing efficiency and decreasing costs. This research specifically seeks to develop an understanding of how clearances …

A Metallomics Study On Protein Function Assignment Using Promol, Venkata Aditya Kovuri

Theses

Metal ions are an integral part in both the structural and functional stability of enzymes. The function of an enzyme is exhibited through its active site region, which carries out the reaction for that particular protein. When a metal ion is present in an active site, it not only acts as a structural support for the active site but is often plays a critical role in the functional behavior of the protein. An exhaustive screening for proposed metal ion active sites was performed through online resources including Metal MACiE, Metal PDB, the Catalytic site Atlas and Metal Mine. A total …

A Search Engine For Finding And Reusing Architecturally Significant Code, Ibrahim Jameel Mujhid

Theses

Architectural tactics are the building blocks of software architecture. They describe solutions for addressing specific quality concerns, and are prevalent across many software systems. Once a decision is made to utilize a tactic, the developer must generate a concrete plan for implementing the tactic in the code. Unfortunately, this is a non-trivial task even for experienced developers. Developers often resort to using search engines, crowd-sourcing websites, or discussion forums to find sample code snippets to implement a tactic. A fundamental problem of finding implementation for architectural patterns/tactics is the mismatch between the high-level intent reflected in the descriptions of these …

An Artificial Neural Networks Based Temperature Prediction Framework For Network-On-Chip Based Multicore Platform, Sandeep Aswath Narayana

Theses

Continuous improvement in silicon process technologies has made possible the integration of hundreds of cores on a single chip. However, power and heat have become dominant constraints in designing these massive multicore chips causing issues with reliability, timing variations and reduced lifetime of the chips. Dynamic Thermal Management (DTM) is a solution to avoid high temperatures on the die. Typical DTM schemes only address core level thermal issues. However, the Network-on-chip (NoC) paradigm, which has emerged as an enabling methodology for integrating hundreds to thousands of cores on the same die can contribute significantly to the thermal issues. Moreover, the …

Contact Angle And Ift Measurements Of Smart Water At Elevated Temperatures And Pressures For Evaluating Wettability In A Selected Carbonate Reservoir In The Uae, Jassim Abubacker Ponnambathayil

Theses

Water flooding has been regarded as a well-known secondary oil recovery method. In the recent years, extensive research on crude oil, brine, and rock systems has acknowledged that the composition of the injected water can change wetting properties of the reservoir during a water flood in a promising way to improve oil recovery. Hence, injection of “smart water” with correct salinity and composition is considered as a tertiary recovery method. The mechanism behind wettability alteration that is promoted by smart water injection has been a topic of discussion in carbonate and sandstone formations. In this work, some key properties of …

Coercion Negates Responsibility: A Case For Indirect Compelled Doxastic Coercion And Adaptive Preferences As Effects Of Practical Coercion, Rc Patterson

Theses

In part 1 of this project, I

1. define different forms of coercion;
2. outline adaptive preferences;
3. argue that indirect doxastic coercion is the unconscious element in adaptive preferences; and
4. contextualize these concepts in the black experience.

In part 2, I

1. demonstrate how certain segregation policies are a mix of direct practical coercion and indirect doxastic compelled coercion, or indoctrination;
2. In the final section I argue that, under desert theory, coercion negates responsibility.

Personalities Of The Chinese Zodiac, Tang-Hsuan Liu

Theses

3D animation has been trending for many years now. Many stories and the characters in those stories are being re-designed and represented by 3D.

Stories I grew up with in Taiwan are so different from those popular in Western culture. While I enjoyed Snow White, Sleeping Beauty and Mickey Mouse, I also loved many classic Chinese stories, one of them being that of the Chinese Zodiac.

This story is about animals having a race to decide who will be the only 12 animals that represent each year. They are rat, ox, tiger, rabbit, dragon, snake, horse, goat, monkey, chicken, dog …

Shape Representation Using The Helmholtz Equation, Laura A. Rolston

Theses

Image classification uses a learning procedure to predict class labels based on quantitative characteristics of an image. Typical approaches involve first extracting features from a set of labeled images and using a subset of those images and their features as a "training set" to train a classifier. The classifier is then applied to the test images to predict their labels. In this thesis, we focus on shape classification and propose new features to be used for classifying binary images. Specifically, we propose new features based on the hitting time distribution of a Brownian motion process defined on the shape.

It …

Opto-Mechanical Design Of Synchrotron Radiation-Based Far-Infrared Spectroscopic Ellipsometer With Strong Magnetic-Field, Ahmad Abbas Chaudhry

Theses

The objective of this dissertation is to present opto-mechanical design of a synchrotron radiation based far-infrared spectroscopic ellipsometer with a strong external magnetic-field capability. Since high magnetic field has enabled major breakthrough in science such instrument will be highly important to the field of condensed matter physics and characterization of advanced electronic materials. This instrument will be installed at the multi-User facility with the most advanced synchrotron light source: Natonal Synchrotron Source (NSLS-II) at Brookhaven National Laboratory (BNL).The proposed here instrument is capable to measure full Mueller matrix spectroscopic ellipsometry spectra in high magnetic fields of up to 9 Tesla. …

An Fpga Implementation Of A Sleep Enabled Pon System, Zheyu Liu

Theses

Owing to the growing demand for bandwidth-hungry video-on-demand applications, Passive Optical Network (PON) has been widely considered as one of the most promising solutions for broadband access. Environmental concerns motivated network designers to lower energy consumption of optical access networks. A well-known approach to reduce energy consumption is to allow network elements to switch to the sleep mode.

In this framework, an improved Optical network Unit (ONU) architecture in TDM-PON is proposed to reduce the handover time of status switching. Energy-saving performances of current and improved architectures are compared in different scenarios. The simulation results show that by applying a …

Computational And Experimental Determination Of The Hydrodynamics In A Stirred Unbaffled Vessel Provided With Angle-Mounted Axial Impellers, Ji Ma

Theses

In most industrial applications, stirred tanks and reactors are typically provided with baffles to improve their mixing characteristics. However, in a number of pharmaceutical production facilities unbaffled vessels are commonly used. The absence of baffles is preferred in such cases because it reduces the potential for contamination and makes cleaning the vessel between batches easier. However, the lack of baffles also has a negative impact on the system’s hydrodynamics since it often results in poor mixing of the batch, especially if the impeller is centrally placed, since the liquid in such a system is subject to a strong tangential flow, …

Investigating Neural Mechanisms Of Hand Movements In Virtual Reality, Chuang Mu

Theses

Mirror visual feedback (MVF), a technique by which movement of one limb is perceived as movement of the contralateral limb, has the capacity to relieve phantom limb pain or promote motor recovery of the upper limbs after stroke (Ramachandran et al., 1995). Functional MRI studies have demonstrated activation of the motor areas in the hemisphere ipsilateral to the moving hand in response to MVF. However, the neural mechanisms of MVF are still unclear. This Electroencephalography (EEG) study was designed to investigate the timing of neural responses to MVF presented in virtual reality. 16 right-handed, neurologically healthy subjects participated in a …

A Study Of Kinematics And Kinetics In Time-Constrained Arm Movements, Oyindamola Owoeye

Theses

Several studies such as the equilibrium point hypothesis (EPH) purport that the motor signals that descend from the brain instead of encoding muscle torques, influence an existing relationship between muscle torque and body configuration.

In the present study, the possibility of torque depending explicitly on position was tested using a task in which subjects (N=5) moved a simulated weightless frictionless mass through a small (<8 degree) elbow extension in order to move a cursor on a screen to a target location. Each subject completed 720 trials. On ~10% of trials the simulated mass was increased unknown to the subject. The relationship between the cursor’s position and the torque applied to the system was held constant even when the simulated mass was increased. Thus, any change in torque produced was neither due the subjects’ perception of the mass nor due to their perception of the cursor. The time at which the subjects torque changed direction was seen to be significantly different (p<0.005) during trials which the mass changed. This change in torque is concluded to be position-dependent. However the possibility of this being a merely mechanical effect could not be ruled out by due to poor EMG collection.

A post-hoc analysis of different position-dependent motor control models, was done. Particularly, an exponential spring model, a linear spring model, and a linear spring with relative damping model were each tested to see how well …

Triplex Dna Receptor-Gold Nanoparticle Conjugates For Detection Of Oxidized Dna Base, Qingyu Xing

Theses

Oxidations of DNA nucleobases are believed to be one of the sources of aging and some age-dependent disease, such as cancer. Human body have various mechanisms to repair damaged DNA and base-excision-repair is one mechanism for removing those oxidized nucleobases. This mechanism processes in the cells by cutting the oxidized nucleobases from deoxyribose and letting them excrete though urine. Detection of those abnormal nucleobases in urine has been suggested as a convenient way of early cancer diagnosis. 5-OHU (5-hydroxyuracil), the oxidation product of cytosine, is one of those abnormal nucleobases and it potentially forms base pairs with all four DNA …

Realization Of Dynamixel Servo Plant Parameters To Improve Admittance Control For A Compliant Human-Robot Interaction, Ahmad Zahid Rao

Theses

In theory, admittance control offers a very effective method of implementing smooth human-robot interaction. It allows the user’s applied force to control the movement of a powerful robot as if the robot were a small, passive mass. However, the real-world application of admittance control faces limitation posed by the dynamics of servo motors, the accuracy of the force sensors, and the computation speed of processors.

This research investigates the limitations on achieving compliant passive behavior when using state-of-the-art actuators, sensors and processors. The work involves characterizing the dynamic behavior of the servo motors, development of improved differential equations representing admittance …

Analyses Of Amber Mutants Of Salmonella Phage Spn3us, Andrea Denisse Benítez Quintana

Theses

The giant Salmonella enterica phage SPN3US belongs to the ϕKZ-related phages which are amongst the most complex virions of prokaryotic viruses, even more complex than most eukaryotic viruses. SPN3US for example assigns 46% of its 240kbp genome to code for virion proteins. We have limited knowledge about these giant phages as they encode extremely diverged genes, from other phages and even to one another. The ϕKZ-related phages possess large genomes and correspondingly large and complex capsids, two sets of fragmented RNAP β and β’-like proteins and they also exhibit an unusual replication having a DNA polymerase split into two polypeptides. …