Digital Commons Network^™

Analysis Of Geosynthetic-Reinforced Tailings Dam Slopes Subjected To Surface Loads, Francis Otieno, Sanjay Kumar Shukla

Research outputs 2022 to 2026

This study presents an extensive numerical investigation of the stability of a geosynthetic-reinforced tailings dam embankment slope subjected to surface loads from retained pyrite tailings slurry upstream of the dam. The analysis was performed on an embankment with an inclination of 1V:2.5H on the upstream slope and 1V:2H on the downstream slope. The dam embankment rests directly on previously deposited pyrite tailings that have dried over time and are sufficiently consolidated to support the embankment. The variable parameters considered in this study include the geosynthetic reinforcement length across the failure zone, effective cohesion (c′), effective angle of internal friction (ϕ′), …

Belonging-With Country: Diffracting Equity, Inclusion And Care In Australian Early Childhood Education, Amanda J. Binns, Elizabeth Jackson-Barrett

Research outputs 2022 to 2026

This article revisits the widely used yet underexamined concepts of equity, inclusion and belonging in Australian early childhood education. Building on Sumsion and Wong's interrogation of ‘belonging’ in the original Early Years Learning Framework (EYLF) for Australia V2.0, it traces how the concept has been taken up across policy, practice and scholarship, including EYLF V2.0 and contemporary work on care, book sharing and cultural responsiveness. It argues that these approaches, while well intentioned, often individualise belonging, obscure ongoing colonial relations and privilege Euro-Western, human-centred ontologies that normalise some children, families and places while marginalising others, particularly Aboriginal and Torres Strait …

Neurophysiological And Neuromuscular Responses Associated With The Repeated Bout Effect Following Eccentric Exercise In Healthy Adults: A Systematic Review And Meta-Analysis, Oliver Hayman, Abdulrahman T. Alsowail, Benjamin Griffiths, Stuart R. Gray, Glyn Howatson, Ken Nosaka, Stuart Goodall, Ashlyn K. Frazer, Dawson J. Kidgell

Research outputs 2022 to 2026

Muscle damage severity decreases after repeated eccentric exercise bouts (the repeated bout effect [RBE]), but whether accompanying neural and neuromuscular changes contribute to protection or arise secondary to reduced damage remains unclear. This systematic review and meta-analysis compared neurophysiological and neuromuscular responses between initial and repeated eccentric bouts in healthy adults. Eight databases were searched from November 1990 to January 2025, and Hedges’ g was calculated where outcomes were comparable. Given the small number of contributing studies, all pooled analyses were considered exploratory. Twelve studies met the inclusion criteria. Twitch/evoked force showed recovery-compatible point estimates at 24 h (g = …

Raising Children In Precarious Spaces: Coping Strategies Of Young Mothers In Urban Slums Of Accra, Ghana, Portia Nana Ama Brempong, Samuel Eduaful, Kwabena Frimpong-Manso, Phoebe Afram

Research outputs 2022 to 2026

This study examined coping strategies of young mothers raising children in urban slum communities in Accra, Ghana. Guided by Jack’s Ecological Influences Framework and Interpretative Phenomenological Analysis, interviews were conducted with 20 young mothers aged 18–35 in Old Fadama and African Eleven. The findings revealed five strategies: spiritual coping and religious reliance; adaptive food management strategies; psychological endurance and emotional regulation; community-based support networks; and informal financial management and credit utilization. Environmental stressors, including crime and social disorder, shaped mothers’ parenting experiences and created tensions in transmitting values to their children. These findings suggest that young mothers’ coping strategies are …

Re-Thinking Bodies In Cross-Border Physical Education Teacher Education Policies: A Posthuman Perspective, Valeria Varea, Erik Backman

Research outputs 2022 to 2026

While posthumanist studies have increased in Physical Education Teacher Education (PETE), traditional analytical approaches are still often employed for the analysis of policy documents, which limits the ways that we can understand policy work. The aim of this paper is to explore how bodies are conceptualised and assembled in PETE policies in one institution from Sweden and one from Australia using a posthumanist perspective. We understand these policies as material doings and enactments of the world that can allow us to think differently about PETE. By using the concepts of assemblage and plugging in, three result categories are presented: (1) …

When Dying Patients Fall Silent: How Nurses Navigate Decision-Making In The Last Days Of Life—A Qualitative Study, Tricia O'Connor, Aileen Collier, Karen Strickland, Carla Thamm, Catherine Paterson

Research outputs 2022 to 2026

Aim: To explore nurses' perspectives on decision-making processes and influencing factors when caring for unresponsive dying patients in the last days of life. Design: A qualitative interpretive study.

Methods: Using purposive recruitment and informal peer referral, twenty-one nurses from a specialist palliative care service in a metropolitan city in Australia were interviewed between July 2024 and January 2025. Data were analysed using reflexive thematic analysis. Decision-making theory was used as an interpretive lens.

Findings: Two themes were generated: ‘The patient as an absent presence’ and ‘Enacting agency through embodied cognition and relational attunement’, together with five interconnected subthemes. The analysis …

Application Of Generative Artificial Intelligence By Nurse Academics In Higher Education: A Scoping Review, Jennifer Hamilton, Martina Costello, Lesley Barr, Simon Cooper, Martin Jones

Research outputs 2022 to 2026

Aim: To systematically map existing research on nurse academics incorporation of generative artificial intelligence when developing teaching and learning resources in higher education and to identify knowledge gaps and future research. Background: Generative artificial intelligence technology is rapidly evolving in healthcare and it's use in nursing higher education is developing. However, concerns regarding its adoption in higher education relate to academic integrity and ethical considerations, including privacy, confidentiality, bias and critical thinking development. Generative artificial intelligence tools present new pedagogy possibilities in nursing higher education; however, the scope and impact of its adoption is unclear. Methods: The Joanna Briggs Institute …

Between Guidelines And Guilt: Parenting Through The Chaos Of Screen-Time Discourse, Stephanie C. Milford

Research outputs 2022 to 2026

Digital parenting today is shaped by shifting guidelines, moralised discourse, and often unstable institutional advice, leaving families navigating uncertainty without meaningful support. Drawing on governmentality theory and media studies, this piece examines how screentime discourse can position parents as primarily responsible for risks that are in part, produced by systems outside the home. Using the Australian policy reversal on YouTube as a case study, it highlights how inconsistent guidance can erode parental confidence and at times sustain cycles of shame and surveillance. Rather than consistently addressing structural factors such as platform design and algorithmic amplification, media and policy narratives displace …

Culture, Community, And Development: Unpacking The ‘Socio-Cultural Milieu Dynamics’ Of Solomon Islands And Their Influence On Australia's Aid Localisation, Mark Opoku Amankwa, Gladys Nangira Murruka, Kwadwo Adusei-Asante, Vicki Frances Banham, Clement Amponsah, Emmanuel Enyinful

Research outputs 2022 to 2026

Using public ethnography anchored in the post-development theory and interpretivist epistemological paradigm, this study examines what we term the ‘socio-cultural milieus dynamics’ (SCMD) of the Solomon Islands (SI) and how these shape meaning, discourse, and practice in ways that influence Australia's aid localisation efforts and aid outcomes. The findings indicate that local communities are deeply entrenched in complex SCMD with heterogeneous networks of decision-makers within the ecosystem. These SCMD, we argue, are evident in the structural and contested roles associated with the gendered composition of local committees, the power asymmetries between dominant local elites and subalternised groups, and the relationalities …

Effectiveness Of Prophylactic Foam Dressings In The Prevention Of Sacral Pressure Injuries In At-Risk Hospitalised Patients (Eepoc): A Randomised Control Trial, Rachel M. Walker, Wendy Chaboyer, Lukman Thalib, Sharon Latimer, Haitham Tuffaha, Marie Cooke, Brigid M. Gillespie

Research outputs 2022 to 2026

Background: Hospital-acquired pressure injuries are a serious patient safety issue with the sacrum the most common location. Silicone foam border dressings are increasingly used in hospitalised patients, yet their clinical and cost-effectiveness in preventing pressure injuries is unclear in some patient cohorts. Objective: To determine the clinical and cost-effectiveness of a silicone foam border dressing in preventing sacral hospital acquired pressure injuries in at-risk medical-surgical patients. Methods: A prospective, multi-site, parallel group, pragmatic, superiority randomised controlled trial was conducted in Southeast Queensland, Australia. Medical-surgical adult patients (≥ 18 years) at-risk of pressure injury were recruited and randomly allocated to either …

Drone Endurance In Hydrogen Fuel Cell Hybrid Technologies: Power Architectures And Design Strategies, Yaw Chong Tak, Tarek Abedin, Johnny Koh Siaw Paw, Jagadeesh Pasupuleti, Tan Jian Ding, Tiong Sieh Kiong, K. Kadirgama, F. Benedict, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

This study delivers an exhaustive exploration of novel and hybrid power systems for Unmanned Aerial Vehicles (UAVs) aimed at improving endurance, efficiency, and mission performance. In the wake of increasing requirements for long-endurance and high-performance UAVs, traditional battery systems are limited by their energy density and lifetime. To overcome this, the research compares four primary power sources: hydrogen fuel cells, lithium-based batteries, photovoltaic cells, and supercapacitors, with a focus on their hybrid architecture integration. The originality of this research is in the relative comparison of these power sources in multi-mode UAV operations, with an emphasis on their performance, energy management …

Examining The Factors Influencing Citizen Adoption Of E-Government Chatbot Services In Jordan: A Longitudinal Survey Study, Ibrahim Mohamad, Laurie Hughes, Ali Abdallah Alalwan, Tegwen Malik, Yogesh K. Dwivedi

Research outputs 2022 to 2026

Many governments are focusing on adopting Artificial Intelligence (AI)-based chatbot technology to enhance work efficiency and improve e-government services. Jordan was among the first Middle Eastern countries to implement AI chatbots to offer various e-services to its citizens. While previous studies have examined the adoption of AI chatbots, they have not explored citizen adoption within the Jordanian context. This research investigates the key factors influencing citizen adoption of e-government chatbot services in Jordan by extending the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) theory with additional external variables. A longitudinal survey of 319 Jordanian citizens was conducted, …

Insulin Resistance As A Mediator Of Physical Activity's Effects On Beta-Amyloid Accumulation And Tau Phosphorylation: A Scoping Review, Michael G. Slee, Joanne Scotney, Stephanie R. Rainey-Smith, Kirk I. Erickson, Hamid R. Sohrabi, Giuseppe Verdile, Belinda M. Brown

Research outputs 2022 to 2026

Background Type 2 diabetes is associated with increased Alzheimer’s disease risk and brain beta amyloid (Aβ) burden, suggesting an underlying mechanistic relationship between Alzheimer’s disease and type 2 diabetes. Animal studies show exercise reduces levels of brain Aβ and tau, and while human studies are somewhat limited, some studies have reported physical activity is associated with lower brain Aβ and tau levels. Exercise has well established links to reductions in insulin resistance; thus, as physical activity can impact both insulin resistance and Alzheimer’s disease pathology and/or biomarkers, it is reasonable to hypothesise that a mediating relationship may exist. The objective …

Lack Of Increase In Mercury Contamination In Coastal Western Australia Since European Settlement, Martin Dahl, Larissa Schneider, Harald Biester, Richard Bindler, Antonio Martinez Cortizas, Paul S. Lavery, Miguel A. Mateo, Oscar Serrano

Research outputs 2022 to 2026

Current knowledge of long-term mercury (Hg) deposition is predominantly based on studies from the Northern Hemisphere, leading to a geographical bias in the comprehension of the global Hg cycle. Aiming to contribute to fill this knowledge gap, our study presents a high-resolution Hg record of a seagrass Posidonia australis sedimentary archive encompassing the last 3300 years in the Waychinicup estuary (Western Australia, WA). This setting is an ideal site for studying the natural Hg cycle, as it is located in the southwest of the state, outside the prevailing wind patterns that transport emissions from major Hg sources. Our results show …

Satellite Observations Reveal Ecosystem Resistance And Resilience To Short-Term Water Stress Driven By Dominant Vegetation Along A Rainfall Gradient In Australia, Huanhuan Wang, Qiaoyun Xie, Sally E. Thompson, Caitlin E. Moore, David L. Miller, Erik J. Veneklaas, Richard P. Silberstein, Xing Li, Jingfeng Xiao, Belinda E. Medlyn, William K. Smith

Research outputs 2022 to 2026

Climate change is projected to intensify water stress in many ecosystems and poses threats to their stability, which can be quantified through ecosystem resistance and resilience. Relevant studies mostly focused on multi-year or annual droughts, and in spatially homogeneous or species-specific ecosystems. However, resilience and resistance within complex ecosystems, where different plants exhibit different adaptations and recovery behaviours, are less understood. Using productivity data from satellite-derived GOSIF (Global Orbiting Carbon Observatory-2 Solar-Induced Fluorescence) and flux towers, we examined vegetation responses to short-term (<1 year) water stress events from 2000 to 2018 along the North Australia Tropical Transect, which spans a 1600 mm rainfall gradient and transitions from seasonal mesic to non-seasonal arid ecosystems. We define resistance as productivity maintained during stress relative to a multi-year average baseline, and resilience as the extent to which productivity recovered one year after stress relative to the same baseline. Our results show that ecosystem resistance to water stress was lowest in semi-arid regions but higher in both arid and mesic regions, while ecosystem resilience showed the opposite pattern. These spatial patterns occurred regardless of seasonality and were mainly associated with dominant vegetation type. Woody savanna-dominated mesic regions exhibited highest resistance (0.82 ± 0.13, p < 0.001) and lowest resilience (0.26 ± 0.19, p < 0.001), shrublands in arid areas had intermediate values of both resistance (0.81 ± 0.14, p < 0.001) and resilience (0.27 ± 0.22, p < 0.001), while the grasslands in semi-arid regions had low resistance (0.78 ± 0.15, p < 0.001) and high resilience (0.38 ± 0.24, p < 0.001). The highest likelihood (>75.0 %) of full recovery (i.e., exceeding baseline after one year) occurred during the wet season in …

Towards Carbon Geosequestration: Comparing The Wettability Performance Of Western Australian Altered Basaltic Rock/Co2/Water Systems, Seyi Philemon Akanji, Rossen Sedev, Lionel Esteban, Ausama Giwelli, Trevor Beardsmore, Heather Howard, Joel Sarout, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

Geosequestration of carbon dioxide in basaltic rock formations is considered to have the potential to safely and permanently store significant quantities of this greenhouse gas and thereby mitigate its potential global warming effect. The success of this storage method is primarily dependent on the wettability behaviour of the rock-water-CO2 system, which significantly affects fluid distribution, fluid transport, storage capacity and containment security. This study investigates the wettability performance of several Western Australian altered basaltic rocks, of similar geochemistry, porosity and inter-connection. The wettability behaviour of the basaltic materials is assessed using water containing ions that have been leached from the …

Under-Five Mortality Estimation Methods: A Methodological Systematic Review, Bereket Kefale, Jonine Jancey, Amanuel T. Gebremedhin, Daniel Gashaneh Belay, Gavin Pereira, Gizachew A. Tessema

Research outputs 2022 to 2026

Purpose This methodological systematic review aimed to identify and synthesise the existing under-five mortality (U5M) estimation methods globally. Methods We searched seven databases including Medline, Embase, Scopus, Web of Science, CINAHL, Global Health, and ProQuest Central, as well as grey literature sources from inception to September 25, 2025. The review protocol was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42023465476). Results Fifty-six studies were included in this review. The most frequently employed child mortality estimation method was the indirect method (n = 16), followed by the Global Burden of Disease (GBD) study method (n = 12) …

Unraveling The Significance Of Fecal Microrna Profile In Alzheimer’S Disease, Kavisha Katuwawala, Prashant Bharadwaj, Ian Martins, B. G.D.N.K. De Silva, Vincent Ho, Asiri Dissanayake, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD), a complex neurodegenerative disorder characterised by progressive cognitive decline, affects millions globally. With no current cure, treatment focuses on symptom management and slowing disease progression. Early identification is therefore crucial. Fecal microRNA (miRNA) analysis is emerging as a promising non-invasive diagnostic tool. Evidence suggests that miRNAs present in fecal samples may regulate gene expression linked to AD pathology, impacting cellular functions and disease progression. Dietary factors critically influence gut microbiota composition and diversity, affecting brain health via the gut brain axis. Macronutrients such as carbohydrates, proteins, and fats modulate miRNA expression and gut microbiota, influencing AD risk. …

C2p-M: Critical Connection Protection In Multiplex Graphs, Conggai Li, Wei Ni, Ming Ding, Youyang Qu, Jianjun Chen, Wenjie Zhang, Thierry Rakotoarivelo

Research outputs 2022 to 2026

Multiplex graphs represent diverse real-world interactions among entities, where multiple relationship types coexist within the same set of entities. These graphs introduce privacy risks, as data collectors can exploit cross-layer dependencies to infer hidden and sensitive connections. In this work, we propose a C2P-M framework that identifies and protects critical connections while preserving the structural information in multiplex graphs. Unlike conventional methods for single-layer graphs that perturb all edges uniformly, C2P-M selectively protects critical connections, maintaining the analytical usability of the graph. To achieve this, we introduce the multiplex p-cohesion model, which incorporates new score functions that account for both …

Circulating Tumor Cells In Uveal Melanoma: Multi-Marker Detection And Association With Disease State, Daniel P. De Bruyn, Fabiana Lucia Bassil, Mike Wu, Aaron B. Beasley, Jolanda Vaarwater, Mai N. Van, Jaco Kraan, Robert M. Verdijk, Dion Paridaens, Caroline M. Van Rij, Nicole C. Naus, Annelies De Klein, Elin S. Gray, Erwin Brosens, Emine Kiliç

Research outputs 2022 to 2026

Purpose. Uveal melanoma (UM) is primarily treated with eye-sparing radiotherapy, leaving limited tumor tissue for molecular analysis. Circulating tumor cells (CTCs) may offer a minimally invasive alternative for genomic tumor profiling. This pilot study evaluated the feasibility of a multi-marker CTC capture approach in UM patients at diagnosis, during fractionated stereotactic radiotherapy (fSRT), and at metastatic progression. Methods. Patients with localized or metastatic UM were prospectively enrolled. Peripheral blood samples were collected at baseline, during fSRT, and on detection of metastases. CTCs were captured and enumerated using a multi-marker approach and fluorescence microscopy. Results. A total of 76 patients were …

Decline In Offspring Quantity But Not Quality From Successive Matings In Male Rainforest Drosophila, With No Evidence For Genetic Divergence In Male Mating Behaviour Along Elevational And Density Gradients, Andrew D. Saxon, Eleanor K. O'Brien, Natalie E. Jones, Jon Bridle

Research outputs 2022 to 2026

Fertilisation success is a major component of male fitness, meaning males should capitalise on all opportunities for mating. However, other sources of variation in fitness mean that males often evolve life histories that limit their ability to mate frequently. We quantified mating latency, mating duration, and offspring production in males of the tropical fly Drosophila birchii when presented with up to 4 females consecutively. Males were sourced from isofemale lines from the extremes of 2 elevational gradients (20–1100 m) that show substantial differences in population density, temperature, and humidity. Total offspring sired increased with number of matings achieved, demonstrating substantial …

Effects Of Electroshock Treatment On Microstructure Evolution And Mechanical Properties Of Ti-8al-1mo-1v Alloy, Jian Zhou, Yu Peng Yao, Hong Xin Sun, Chang Liu, Yan Wen, Li Qiang Wang, Lai Chang Zhang, Le Chun Xie, Lin Hua

Research outputs 2022 to 2026

The effect mechanism of electroshock treatment (EST) on microstructure evolution and mechanical property variations of Ti-8Al-1Mo-1V alloy was investigated. The results show that EST results in the phase transformation from the acicular secondary αs to β phase. While the EST time is 0.12 s, the acicular martensitic phase (αM) precipitates. The results of electron backscattered diffraction (EBSD) reveals that the average grain size decreases from 3.95 to 2.53 μm after EST, indicating that the grains are refined, and the significant recrystallization behavior and martensitic transformation occur. The orientation distribution reveals a more uniform distribution of texture, which is caused by …

Exploring The Mechanisms Of Tanshinone Iia In The Treatment Of Intracranial Aneurysm Based On Network Pharmacology And Machine Learning, Wanqi Wang, Lois Balmer, Shaotao Weng

Research outputs 2022 to 2026

Background Intracranial aneurysm (IA) is a cerebrovascular disease with high mortality and limited treatment options. Tanshinone IIA (Tan IIA), a bioactive compound from Salvia miltiorrhiza , has shown vascular protective effects, but its mechanism in the treatment of IA remains unclear. Methods The GSE75436 dataset was used to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was performed to identify disease-related modules. IA targets were obtained from GeneCards and the Comparative Toxicogenomics Database (CTD). Potential targets of Tan IIA were predicted using TCMSP, SwissTargetPrediction, and SymMap. KEGG enrichment analysis was conducted for DEGs, WGCNA modules, disease-related genes, …

Predictors Of Quality Of Family Planning Counselling In Ethiopia: Multilevel Analysis Of The Spa Survey 2021/22, Kalayu Brhane Mruts, Tesfay Brhane Gebremariam, Amanuel Tesfay Gebremedhin

Research outputs 2022 to 2026

Background: High-quality family planning (FP) counselling is essential for informed contraceptive choice, reducing discontinuation, and improving reproductive health. However, many women in sub-Saharan Africa continue to face barriers. This study examined client-, provider-, and facility-level determinants of FP counselling quality in Ethiopia using nationally representative, multi-source data. Methods: We analysed data from the 2021/22 Ethiopia Service Provision Assessment, including 2,224 women who received or were prescribed injectables, pills, or implants. Counselling quality was assessed using a 15-item checklist derived from direct observations and client exit interviews. Multilevel ordinal logistic regression was applied to identify predictors at the client-, provider-, and …

Rapid Decentralized Prostate Cancer Risk Stratification By Portable Liquid Biopsy Analysis Within A Clinical Biosensor Validation Framework, Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke-Lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau

Research outputs 2022 to 2026

Clinical liquid biopsy (e.g., blood or urine) specimens, as a minimally invasive source of crucial molecular information, continue to grow in importance for efficacious targeted cancer treatment. Yet, current molecular profiling technologies are still confined to centralized laboratory testing, which escalates testing costs, result turnaround time, and patient anxiety. Crucially, there is also a scarcity of purposeful clinical validation studies to rigorously evaluate emerging liquid biopsy technologies from research settings to facilitate clinical translation. Here, we report liquid biopsy biosensor advancements in achieving rapid, accurate, and decentralized molecular profiling of a clinically accredited prostate cancer (PCa) urinary circulating RNA biomarker …

Success Factors For Effective Workplace Bullying Interventions: A Scoping Review, Kate Blackwood, Azadeh Shafaei, Tim Bentley, Maryam Omari, Dayna Fawkes

Research outputs 2022 to 2026

Purpose – The study aimed to comprehensively review the existing evaluated interventions on preventing workplace bullying and provide recommendations on the success factors for designing effective workplace bullying interventions. Design/methodology/approach – We used a scoping review framework (PRISMA-ScR) to explore, identify and shortlist a range of articles evaluating workplace bullying interventions. Specifically, this review examined the content and relative effectiveness of workplace bullying interventions related to their design and implementation. Findings – The study has found that no one specific intervention type consistently produced the desired outcome. However, interventions that are multifaceted, multi-level, focused on the organisational level, owned by …

Women In The Australian Mining Industry, Michelle Gander, Fleur Sharafizad, Aglae Hernandez Grande, Heidi Vivian, Mahan Poorhosseinzadeh, Kate Blackwood

Research outputs 2022 to 2026

This report synthesises existing research on women’s participation in the Australian mining industry to identify the structural and cultural factors shaping gender inequality across the sector.

Drawing on research conducted over the past four decades, the report brings together what is currently known about how mining workplaces operate and how organisational practices, work arrangements, and site cultures shape the experiences of women across the sector. While many companies have introduced diversity and inclusion initiatives aimed at improving gender balance, the evidence suggests that challenges persist in areas such as operational roles, leadership pathways, and workplace culture.

Specifically, the report examines …

Adjuvant Pembrolizumab For Stage Iib Or Iic Melanoma: A Secondary Analysis Of A Randomized Clinical Trial, Sancy A. Leachman, Jason J. Luke, Paolo A. Ascierto, Georgina V. Long, Muhammad Khattak, Piotr Rutkowski, Zhi Jin Xu, Mizuho Fukunaga-Kalabis, Clemens Krepler, Alexander M.M. Eggermont, Dirk Schadendorf

Research outputs 2022 to 2026

Importance Patients with melanoma are at risk of developing subsequent cutaneous malignant neoplasms, and the effect of prior immunotherapy is unknown. Objective To analyze new skin cancers in participants with high-risk stage II melanoma treated with adjuvant pembrolizumab or placebo. Design, Setting, and Participants The multicenter double-blind, phase 3 KEYNOTE-716 randomized clinical trial enrolled 976 participants 12 years or older with completely resected stage IIB or IIC cutaneous melanoma between September 23, 2018, and November 4, 2020. Follow-up was completed on February 16, 2024. This analysis was not prespecified in the trial protocol. Interventions Participants were randomly assigned to receive …

Energy Poverty, Economic Growth And Environmental Degradation In South Asia: Do Energy Resources Matter?, Memona Rasheed, Hooi Hooi Lean, Nam Foo

Research outputs 2022 to 2026

Developing countries can combat energy poverty by enhancing renewable energy and economic growth with minimal adverse environmental effects. In this paper, we present a comprehensive analysis of energy poverty, renewable energy, economic growth, carbon dioxide emissions, and urbanization (URB) in South Asian countries from 1990 to 2021, focusing on Pakistan, India, Bangladesh, and Sri Lanka. We employed econometric analysis techniques like Panel Pooled Mean Group (PMG)-Autoregressive Distributed Lag (ARDL), Fully Modified Ordinary Least Squares (FMOLS), and Dynamic Ordinary Least Squares (DOLS) to provide empirical results, as they enable panel data and control for endogeneity. The findings suggested that the fight …

Numerically Evaluating The Effect Of Extrusion Angle On Material Flow And Thermal Behaviour During Additive Friction Extrusion Deposition (Afed), Numan Habib, Ferdinando Guzzomi, Ana Vafadar

Research outputs 2022 to 2026

Additive Friction Extrusion Deposition (AFED), also known as “SoftTouch”, is an emerging friction-based Additive Manufacturing (AM) technology allowing material to soften before the deposition, increasing the printing speed and reducing cost [1]. However, high power is required during the process, as excessive force is needed to extrude enough material through the printing head. This study investigates how extrusion angle and tool rotational speed affect thermal distribution and material flow in AFED to minimise power consumption. A three-dimensional computational fluid dynamics (CFD) model is proposed, and ANSYS ^® Workbench CFD code (Fluent) is used to discretise the CFD model. A User-Defined …