Digital Commons Network^™

Consecutive Dosing Of Uvb Irradiation Induces Loss Of Abcb5 Expression And Activation Of Emt And Fibrosis Proteins In Limbal Epithelial Cells Similar To Pterygium Epithelium, M. Domdey, M. A. Kluth, C. Maßlo, C. Ganss, Markus H. Frank, N. Y. Frank, M. T. Coroneo, C. Cursiefen, M. Notara

Research outputs 2022 to 2026

Pterygium pathogenesis is often attributed to a population of altered limbal stem cells, which initiate corneal invasion and drive the hyperproliferation and fibrosis associated with the disease. These cells are thought to undergo epithelial to mesenchymal transition (EMT) and to contribute to subepithelial stromal fibrosis. In this study, the presence of the novel limbal stem cell marker ABCB5 in clusters of basal epithelial pterygium cells co-expressing with P63α and P40 is reported. ABCB5-positive pterygium cells also express EMT-associated fibrosis markers including vimentin and α-SMA while their β-catenin expression is reduced. By using a novel in vitro model of two-dose UV-induced …

Sediment Accumulation And Carbon Burial In Four Hadal Trench Systems, Kazumasa Oguri, Pere Masqué, Matthias Zabel, Heather A. Stewart, Gillian Mackinnon, Ashley A. Rowden, Peter Berg, Frank Wenzhöfer, Ronnie N. Glud

Research outputs 2022 to 2026

Hadal trenches are considered to act as depocenters for organic material, although pathways for the material transport and deposition rates are poorly constrained. Here we assess focusing, deposition and accumulation of material and organic carbon in four hadal trench systems underlying different surface ocean productivities; the eutrophic Atacama and Kuril-Kamchatka trenches, the mesotrophic Kermadec trench and the oligotrophic Mariana Trench. The study is based on the distributions of naturally occurring ²¹⁰Pb_ex, ¹³⁷Cs and total organic carbon from recovered sediment cores and by applying previously quantified benthic mineralization rates. Periods of steady deposition and discreet mass-wasting deposits were …

Socioeconomic, Ethnocultural, Substance- And Cannabinoid-Related Epidemiology Of Down Syndrome Usa 1986–2016: Combined Geotemporospatial And Causal Inference Investigation, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Background: Down syndrome (DS) is the commonest of the congenital genetic defects whose incidence has been rising in recent years for unknown reasons. This study aims to assess the impact of substance and cannabinoid use on the DS Rate (DSR) and assess their possible causal involvement. Methods: An observational population-based epidemiological study 1986–2016 was performed utilizing geotemporospatial and causal inferential analysis. Participants included all patients diagnosed with DS and reported to state based registries with data obtained from National Birth Defects Prevention Network of Centers for Disease Control. Drug exposure data was from the National Survey of Drug Use and …

Species Traits And Geomorphic Setting As Drivers Of Global Soil Carbon Stocks In Seagrass Meadows, H. Kennedy, J. F. Pagès, D. Lagomasino, A. Arias-Ortiz, P. Colarusso, J. W. Fourqurean, M. N. Githaiga, J. L. Howard, D. Krause-Jensen, T. Kuwae, Paul S. Lavery, P. I. Macreadie, N. Marbà, Pere Masqué, I. Mazarrasa, T. Miyajima, Oscar Serrano, C. M. Duarte

Research outputs 2022 to 2026

Our knowledge of the factors that can influence the stock of organic carbon (OC) that is stored in the soil of seagrass meadows is evolving, and several causal effects have been used to explain the variation of stocks observed at local to national scales. To gain a global-scale appreciation of the drivers that cause variation in soil OC stocks, we compiled data on published species-specific traits and OC stocks from monospecific and mixed meadows at multiple geomorphological settings. Species identity was recognized as an influential driver of soil OC stocks, despite their large intraspecific variation. The most important seagrass species …

State Trends Of Cannabis Liberalization As A Causal Driver Of Increasing Testicular Cancer Rates Across The Usa, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Background:

The cause of the worldwide doubling-tripling of testicular cancer rates (TCRs) in recent decades is unknown. Previous cohort studies associated cannabis use with TCR including dose–response relationships but the contribution of cannabis to TCRs at the population level is unknown. This relationship was tested by analyzing annual trends across US states and formally assessed causality. Four US datasets were linked at state level: age-adjusted TCRs from Centers for Disease Control Surveillance Epidemiology and End Results database; drug use data from annual National Survey of Drug Use and Health including 74.1 % response rate; ethnicity and median household income data …

Likeability And Perceived Effectiveness Of Messages Designed To Encourage Physical Activity Participation Among Older Adults, Michelle I. Jongenelis, Ben Jackson, Robert U. Newton, Simone Pettigrew

Research outputs 2022 to 2026

Issue addressed: Older adults are significantly less likely than their younger counterparts to engage in physical activity. Comprehensive policies to support healthy ageing thus need to include components encouraging greater participation in physical activity in later life. This study tested potential messages for use in health communication campaigns aimed at increasing physical activity among older adults. Methods: Twelve written messages designed to encourage older adults to increase their levels of physical activity were rated by Australians aged 60-92 years (n = 369; 54 % female) on the variables of likeability and perceived effectiveness. Results: Ratings for all the tested messages …

Adherence To Screening And Management Guidelines Of Maternal Group B Streptococcus Colonization In Pregnancy, Sabine Pangerl, Deborah Sundin, Sadie Geraghty

Research outputs 2022 to 2026

Aims: To investigate Group B Streptococcus (GBS) colonization in pregnancy; adherence to antenatal GBS screening and adherence to the intrapartum antibiotics protocol within two models of care (midwifery and non-midwifery led). Design: This retrospective quantitative study has employed a descriptive design using administrative health data. Methods: Data from five maternity hospitals in metropolitan and regional Western Australia that included 22,417 pregnant women who gave birth between 2015 and 2019 were examined, applying descriptive statistics using secondary data analysis. Results: The study revealed an overall GBS colonization rate of 21.7% with similar rates in the different cohorts. A lower adherence to …

Life-Cycle Assessment Of Fibre-Reinforced Polymers Dwellings Compared To Traditional Structures, Afsaneh Valizadeh, Farhad Aslani

Research outputs 2022 to 2026

Fibre-reinforced polymers (FRP) have been presented as materials that possess properties that are comparable to conventional building materials, while also being more sustainable. This study describes the material and its properties and compares the materials using a life-cycle assessment (LCA) modelling approach. The objective of this paper is to perform a cradle-to-grave (from resource extraction to the disposal stage) analysis of pultruded FRP material and compare it to conventional building materials used in a typical dwelling. This analysis was conducted in accordance with LCA standard EN15978. A streamlined LCA was conducted, whereby the major impacts observed included the global warming …

Self-Reported Throwing Volumes Are Not A Valid Tool For Monitoring Throwing Loads In Elite Australian Cricket Players: An Observational Cohort Study, Zachariah G. Hoyne, Ashley J. Cripps, Andrea B. Mosler, Christopher Joyce, Paola T. Chivers, Rob Chipchase, Myles C. Murphy

Research outputs 2022 to 2026

Objectives: To determine the concurrent validity of player self-reported and independently observed throwing volume. Examine whether sex, playing position, or time to upload self-reported data post training influences the accuracy of self-reported throwing loads. Design: Cross-sectional cohort study.

Methods: A total of 8 female and 18 male elite cricket players participated in the study. Overarm throws from 12 training sessions during the 2020–21 cricket year were observed. Player self-reported throwing volume data were retrieved post training, with the time difference between session completion and self-reported data upload recorded.

Results: A moderate positive correlation was found between self-reported and observed throwing …

Developing An Alcohol And Other Drug Serious Game For Adolescents: Considerations For Improving Student Engagement, Joanna Nicholas, Brennen Mills, Sara Hansen, Stephen J. Bright, Heather Boyd, Luke Brook, Jess Watson, Luke Hopper

Research outputs 2022 to 2026

Objectives: To explore perceptions of alcohol and other drug (AOD) education and digital game design preferences among Australian adolescents with the goal of identifying key factors to promote engagement in an AOD serious game for Australian secondary school students. Methods: Semi-structured focus groups were conducted with 36 adolescents aged between 13 and 18 years. Qualitative data was analysed using thematic analysis. Results: Participants described heightened engagement with AOD education that incorporated relatable and relevant real-life stories and interactive discussions. They also expressed a desire for learning to focus on practical strategies to reduce AOD harm and overcome social pressure to …

A Tailored Occupational Therapist-Led Vocational Intervention For People With Stroke: Protocol For A Pilot Randomized Controlled Trial, Sophie O'Keefe, Kathryn Radford, Amanda Farrin, Jodi Oakman, Serena Alves-Stein, Geoffrey Cloud, Jacinta Douglas, Mandy Stanley, Natasha A. Lannin

Research outputs 2022 to 2026

Background: Resuming work after stroke is a common goal of working-age adults, yet there are few vocational rehabilitation programs designed to address the unique challenges faced following stroke. The Work intervention was developed to address these gaps. Objective: This paper presents a protocol that outlines the steps that will be undertaken to pilot both the intervention and trial processes for the Work trial. Methods: The Work trial is a 2-arm, prospective, randomized, blinded-assessor study with intention-to-treat analysis. A total of 54 adults of working age who have experienced a stroke <4 months prior will be randomized 1:1 to either (1) an experimental group who will receive a 12-week early vocational intervention (Work intervention) plus usual clinical rehabilitation or (2) a control group who will receive only their usual clinical rehabilitation. Results: Outcomes include study and intervention feasibility and intervention benefit. In addition to evaluating the feasibility of delivering vocational intervention early after stroke, benefit will be assessed by measuring rates of vocational participation and quality-of-life improvements at the 3- and 6-month follow-ups. Process evaluation using data collected during the study, as well as postintervention individual interviews with participants and surveys with trial therapists, will complement quantitative data. Conclusions: The results of the trial will provide details on the feasibility of delivering the Work intervention embedded within the clinical rehabilitation context and inform future trial processes. Pilot data will enable a future definitive trial to determine the clinical effectiveness of vocational rehabilitation when delivered in the early subacute phase of stroke recovery.

Application Of A Sustainability Framework To Enhance Australian Food Literacy Programs In Remote Western Australian Communities, Leisha M. Aberle, Julia R. Platts, Marie A. Kioutis, Louise M. Haustead, Stephanie L. Godrich

Research outputs 2022 to 2026

Issue addressed: Food literacy programs aim to build individuals’ knowledge, skills and self-efficacy to adopt healthy food choices conducive to reducing the risk of chronic diseases, such as obesity. Foodbank WA’s (FBWA) Healthy Food for All ® nutrition programs have supported the improvement of food literacy knowledge and skills among vulnerable people living in the Pilbara. Methods: A Sustainability Framework containing ten sustainability factors was overlaid with social ecological model (SEM) levels of influence to form a matrix. The use of this matrix facilitated sustainability strategy appraisal within three food literacy programs delivered in remote WA. Results: Programs included multiple …

Characterization And Determinant Factors Of Critical Illness And In-Hospital Mortality Of Covid-19 Patients: A Retrospective Cohort Of 1,792 Patients In Kenya, Isinta M. Elijah, Endawoke Amsalu, Xuening Jian, Mingyang Cao, Eric K. Mibei, Danvas O. Kerosi, Francis G. Mwatsahu, Wei Wang, Faith Onyangore, Youxin Wang

Research outputs 2022 to 2026

Limited data is available on the coronavirus disease 2019 (COVID-19), critical illness rate, and in-hospital mortality in the African setting. This study investigates determinants of critical illness and in-hospital mortality among COVID-19 patients in Kenya. We conducted a retrospective cohort study at Kenyatta National Hospital (KNH) in Kenya. Multivariate logistic regression and Cox proportional hazard regression were employed to determine predictor factors for intensive care unit (ICU) admission and in-hospital mortality, respectively. In addition, the Kaplan-Meier model was used to compare the survival times using log-rank tests. As a result, 346 (19.3 %) COVID-19 patients were admitted to ICU, and …

Combining Security And Reliability Of Critical Infrastructures: The Concept Of Securability, Leandros Maglaras, Helge Janicke, Mohamed Amine Ferrag

Research outputs 2022 to 2026

The digital revolution has made people more dependent on ICT technology to perform everyday tasks, whether at home or at work. The systems that support critical aspects of this smart way of living are characterized as critical, and the security level of such systems is higher as compared to others. The definition of the criticality of a system is a rather difficult exercise, and for that reason, we have seen novel cybersecurity regulations to introduce the idea of digital managed services, which include security monitoring, managed network services, or the outsourcing of business processes that are are critical to the …

Development Of Thai Sensory Patterns Assessment Tool For Children Aged 3–12 Years: Caregiver-Version, Revadee Sutthachai, Anuchart Kaunnil, Supaluck Phadsri, Ilada Pomngen, Mandy Stanley, Tiam Srikhamjak

Research outputs 2022 to 2026

Most existing tools for measuring sensory patterns of children have been developed in Western countries. These tools are complex and may not be culturally appropriate for other contexts that require specific knowledge in the clinical perspective. The aim of this study was to develop a simplified tool called the Thai Sensory Patterns Assessment (TSPA) tool for children. It is designed for children ages 3–12 years old to be completed by their caregiver. The process of creating the tool consisted of drafting a questionnaire and interpreting the result. Partial psychometrics were completed during item development, content validity of items was assessed …

Suicide Exposure Experience Screener For Use In Therapeutic Settings: A Validation Report, Myfanwy Maple, Julie Cerel, Rebecca Sanford, Fiona Shand, Philip J. Batterham, Navjot Bhullar

Research outputs 2022 to 2026

Introduction: A brief screener assessing experience of exposure to suicide for use in therapeutic settings is warranted. To examine the concurrent validity of such a screening tool, labeled as the Suicide Exposure Experience Screener (SEES), the associations of the two SEES items: (i) reported closeness with the person who died by suicide and (ii) perceived impact of suicide death with psychological distress are presented. Methods: Five separate datasets comprising surveys from Australia, Canada, and the United States (Ncombined = 7782) were used to provide evidence of concurrent validity of closeness and impact of suicide exposure. Results: Overall, closeness and impact …

Developing Culturally Appropriate Food Literacy Resources For Aboriginal Children With Foodbank Wa’S Superhero Foods®, Jennifer Tartaglia, Roslyn Giglia, Jill Darby

Research outputs 2022 to 2026

Issue addressed

In Australia, food sovereignty of traditional landowners has been marginalised by the globalisation of food systems and resulted in limited opportunities for children to experience familiar bush tucker foods as healthy choices, particularly in a school environment. Superhero Foods^® themed teaching resources focus on the development of nutrition education materials that included traditional Aboriginal foods together with contemporary foods readily available in regional/remote communities.

Methods

Consultation with an Aboriginal expert and Aboriginal artist; local, regional/remote teachers and stakeholders informed the development of tailored resources including food cartoon characters, school lesson plans and a storybook. The latter was …

Keynote - D36: Personalized Immunotherapy With A Neoepitope Vaccine, Evx-01 And Pembrolizumab In Advanced Melanoma, Georgina V. Long, Pier Francesco Ferrucci, Adnan Khattak, Tarek M. Meniawy, Patrick Alexander Ott, Michael Chisamore, Thomas Trolle, Agon Hyseni, Erik Heegaard

Research outputs 2022 to 2026

Despite improvements made with checkpoint inhibitor (CPI) therapy, a need for new approaches to improve outcomes for patients with unresectable or metastatic melanoma remains. EVX-01, a personalized neoepitope vaccine, combined with pembrolizumab treatment, holds the potential to fulfill this need. Here we present the rationale and novel design behind the KEYNOTE - D36 trial: an open label, single arm, phase II trial aiming to establish the clinical proof of concept and evaluate the safety of EVX-01 in combination with pembrolizumab in CPI naive patients with unresectable or metastatic melanoma. The primary objective is to evaluate if EVX-01 improves best overall …

Bi-Substituted Ferrite Garnet Type Magneto-Optic Materials Studied At Esri Nano-Fabrication Laboratories, Ecu, Australia, Mohammad Nur-E-Alam, Mikhail Vasiliev, Kamal Alameh

Research outputs 2022 to 2026

Since 2007, at the Electron Science Research Institute (ESRI) nano-fabrication laboratories, Edith Cowan University, Australia, we have devoted research efforts to the synthesis and characterization of bismuth-containing ferrite-garnet-type thin-film magneto-optic (MO) materials of different compositions. We report on the growth and characteristics of radio frequency (RF) magnetron sputtered bismuth-substituted iron-garnet thin films. We study the process parameters associated with the RF magnetron sputter deposition technique and investigate the results of optimizing process parameters. To achieve the best MO properties, we employ a few unique techniques, such as co-sputtered nanocomposite films and all-garnet multilayer structures, as well as the application of …

Clinical Management Of Financial Toxicity - Identifying Opportunities Through Experiential Insights Of Cancer Survivors, Caregivers, And Social Workers, Christopher J. Longo, Louisa G. Gordon, Rebecca L. Nund, Nicolas H. Hart, Laisa Teleni, Carla Thamm, Olivia Hollingdrake, Fiona Crawford-Williams, Bogda Koczwara, Tamara Ownsworth, Stephen Born, Sue Schoonbeek, Leanne Stone, Christie Barrett, Raymond J. Chan

Research outputs 2022 to 2026

Perspectives of cancer survivors, caregivers, and social workers as key stakeholders on the clinical management of financial toxicity (FT) are critical to identify opportunities for better FT management. Semi-structured interviews (cancer survivors, caregivers) and a focus group (social workers) were undertaken using purposive sampling at a quaternary public hospital in Australia. People with any cancer diagnosis attending the hospital were eligible. Data were analysed using inductive-deductive content analysis techniques. Twenty-two stakeholders (n = 10 cancer survivors of mixed-cancer types, n = 5 caregivers, and n = 7 social workers) participated. Key findings included: (i) genuine concern for FT of cancer …

The Reported External Traumas Among People With Diabetes-Related Foot Ulcers And Their Outcomes: A Systematic Review Of Case Reports, Ma'en Zaid Abu-Qamar, Vivien Kemp, Lisa Whitehead

Research outputs 2022 to 2026

The objective of this systematic review was to collate evidence published in case reports on the reported origins of external traumas that contribute to the development of diabetic foot ulcers and their outcomes. The review also aimed to suggest reporting criteria for external traumas contributing to the development of diabetic foot ulcers. The search strategy led to the identification of 1224 articles across six electronic databases. Additional articles were also sourced from other electronic platforms (Google scholar) and the reference lists of the included case reports. Ninety-four articles met the inclusion criteria and were published between 1989 and 2020. The …

Plasma High-Density Lipoprotein Cargo Is Altered In Alzheimer's Disease And Is Associated With Regional Brain Volume, Steve Pedrini, James D. Doecke, Eugene Hone, Penghao Wang, Rohith Thota, Ashley I. Bush, Christopher C. Rowe, Vincent Dore, Victor L. Villemagne, David Ames, Stephanie Rainey-Smith, Giuseppe Verdile, Hamid R. Sohrabi, Manfred R. Raida, Kevin Taddei, Sam Gandy, Colin L. Masters, Pratishtha Chatterjee, Ralph N. Martins, Aibl Research Group

Research outputs 2022 to 2026

Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that high levels could be detrimental, but this effect is likely attributed to Low-Density Lipoprotein (LDL) cholesterol. On the other hand, High-Density Lipoproteins (HDL) cholesterol levels have been associated with reduced brain amyloidosis and improved cognitive function. However, recent findings have suggested that HDL-functionality, which depends upon the HDL-cargo proteins associated with HDL, rather than HDL levels, appears to be the key factor, suggesting a quality over quantity status. In this report, we have assessed the HDL-cargo (Cholesterol, ApoA-I, ApoA-II, ApoC-I, ApoC-III, ApoD, ApoE, ApoH, ApoJ, CRP, and SAA) …

Translation And Cross-Cultural Validation Of A Precision Health Tool, The Suboptimal Health Status Questionnaire-25, In Korean, Zheng Guo, Ruoyu Meng, Yulu Zheng, Xingang Li, Ziqi Zhou, Leilei Yu, Qian Tang, Ying Zhao, Monique Garcia, Yuxiang Yan, Song Manshu, Lois A. Balmer, Jun Wen, Haifeng Hou, Xuerui Tan, Wei Wang, Suboptimal Health Study Consortium (Shsc), Global Health Epidemiology Research Group (Gherg)

Research outputs 2022 to 2026

Background

Suboptimal health status (SHS) is a reversible stage between health and illness that is characterized by health complaints, low energy, general weakness, and chronic fatigue. The Suboptimal Health Status Questionnaire-25 (SHSQ-25) has been validated in three major populations (African, Asian, and Caucasian) and is internationally recognized as a reliable and robust tool for health estimation in general populations. This study focused on the development of K-SHSQ-25, a Korean version of the SHSQ-25, from its English version.

Methods

The SHSQ-25 was translated from English to Korean according to international guidelines set forth by the World Health Organization (WHO) for health …

Longitudinal Changes In Wellbeing Amongst Breastfeeding Women In Australia And New Zealand During The Covid-19 Pandemic, Vanessa S. Sakalidis, Alethea Rea, Sharon L. Perrella, Jacki Mceachran, Grace Collis, Jennifer Miraudo, Stuart A. Prosser, Lisa Y. Gibson, Desiree Silva, Donna T. Geddes

Research outputs 2022 to 2026

The COVID-19 pandemic has impacted new mothers’ wellbeing and breastfeeding experience. Women have experienced changes in birth and postnatal care and restricted access to their support network. It is unclear how these impacts may have changed over time with shifting rates of infection and policies restricting movement and access to services in Australia and New Zealand. This study investigated the longitudinal effect of the COVID-19 pandemic on breastfeeding and maternal wellbeing in Australia and New Zealand. Mothers (n = 246) completed an online survey every 4 weeks for 6 months that examined feeding methods, maternal mental wellbeing, worries, challenges, and …

Heterogeneous Learning Method Of Ensemble Classifiers For Identification And Classification Of Power Quality Events And Fault Transients In Wind Power Integrated Microgrid, Arangarajan Vinayagam, Veerapandiyan Veerasamy, Mohd Tariq, Asma Aziz

Research outputs 2022 to 2026

This paper proposes heterogeneous based ensemble Classifiers (voting and stacking method) to identify and classify different power system disturbances (power quality (PQ), faults, transients, and wind power variation) in wind integrated microgrid network. In the pre-processing stage of classification, a Discrete wavelet transform (DWT) technique is applied to extract the features from power system disturbance signals. The classification process for the proposed ensemble models involves two levels of classification. At the first level, the extracted features from the simulated power system events are used to learn the different individual base classifiers (logistic regression (LR), K-Nearest Neighbor (KNN), and J48 Decision …

Promoting Creativity: Secondary Visual Art Teachers’ Perceptions And Understanding Of Creativity In Ghana, Enock Swanzy-Impraim, Julia E. Morris, Geoffrey W. Lummis, Andrew Jones

Research outputs 2022 to 2026

Developing creativity in learners is contingent on how teachers define and understand creativity. This qualitative multi-site case study investigated secondary visual arts teachers’ perceptions and understanding of creativity in Sekondi-Takoradi in Ghana and the influences that impact their perceptions. Data were gathered from 16 secondary visual arts teachers in Ghana using interviews and documents review. It was evidenced that the secondary visual arts teachers’ perceptions and understanding of creativity are limited and built on historical Ghanaian educational materials. The findings suggest teacher training materials and school-based educational resources in Ghana must be upgraded to extend teachers’ understanding of creativity within …

The Effects Of Perceived Destination Restorative Qualities On Tourists’ Self-Identity: A Tale Of Two Destinations, Xianyang Hu, Songshan (Sam) Huang, Ganghua Chen, Feifei Hua

Research outputs 2022 to 2026

Isolation and anomie caused by the modern life has created multiple identity threats. Tourists’ destination experience has long been considered as a unique way of identity construction. However, little research has investigated whether and how environmental restoration qualities in the tourism context can possibly reinforce self-identity and counteract the effect of identity confusion. Guided by the Attention Restoration Theory, this study aims to develop and test a model to examine the relationships between the dimensions of perceived destination restorative qualities (PDRQs) and tourist self-identity with two tourist samples in China collected in two distinctive destinations (Sample 1, n = 361; …

Thirty-Six Months Recurrence After Acute Ischemic Stroke Among Patients With Comorbid Type 2 Diabetes: A Nested Case-Control Study, Lu Wang, Hongyun Li, Jiheng Hao, Chao Liu, Jiyue Wang, Jingjun Feng, Zheng Guo, Yulu Zheng, Yanbo Zhang, Hongxiang Li, Liyong Zhang, Haifeng Hou

Research outputs 2022 to 2026

Background:

Stroke patients have to face a high risk of recurrence, especially for those with comorbid T2DM, which usually lead to much more serious neurologic damage and an increased likelihood of death. This study aimed to explore determinants of stroke relapse among patients with comorbid T2DM.

Materials and methods:

We conducted this case-control study nested a prospective cohort of ischemic stroke (IS) with comorbid T2DM. During 36-month follow-up, the second stroke occurred in 84 diabetic IS patients who were allocated into the case group, while 613 patients without recurrence were the controls. We collected the demographic data, behaviors and habits, …

Anomaly Detection In Cybersecurity Datasets Via Cooperative Co-Evolution-Based Feature Selection, Bazlur A. N. M. Rashid, Mohiuddin Ahmed, Leslie F. Sikos, Paul Haskell-Dowland

Research outputs 2022 to 2026

Anomaly detection from Big Cybersecurity Datasets is very important; however, this is a very challenging and computationally expensive task. Feature selection (FS) is an approach to remove irrelevant and redundant features and select a subset of features, which can improve the machine learning algorithms’ performance. In fact, FS is an effective preprocessing step of anomaly detection techniques. This article’s main objective is to improve and quantify the accuracy and scalability of both supervised and unsupervised anomaly detection techniques. In this effort, a novel anomaly detection approach using FS, called Anomaly Detection Using Feature Selection (ADUFS), has been introduced. Experimental analysis …

Arthritis Prediction Of Advanced Hepatic Fibrosis In Hfe Hemochromatosis, Lauren Andersson, Lawrie W. Powell, Louise E. Ramm, Grant A. Ramm, John K. Olynyk

Research outputs 2022 to 2026

Objective: To evaluate whether arthritis predicts the likelihood of advanced hepatic fibrosis in HFE hemochromatosis.

Patients and Methods: We conducted a retrospective, cross-sectional analysis of 112 well-characterized patients with HFE hemochromatosis and liver biopsy–validated fibrosis staging recruited between January 1, 1983, and December 31, 2013. Complete clinical, biochemical, hematologic, and noninvasive serum biochemical indices (aspartate aminotransferase to platelet ratio index [APRI] and fibrosis 4 index [FIB4]) were available. Scheuer fibrosis stages 3 and 4, APRI greater than 0.44, or FIB4 greater than 1.1 were used to define advanced hepatic fibrosis. Comparisons between groups were performed using categorical analysis, unpaired or …