Digital Commons Network^™

Intrusion Detection Based On Bidirectional Long Short-Term Memory With Attention Mechanism, Yongjie Yang, Shanshan Tu, Raja Hashim Ali, Hisham Alasmary, Muhammad Waqas, Muhammad Nouman Amjad

Research outputs 2022 to 2026

With the recent developments in the Internet of Things (IoT), the amount of data collected has expanded tremendously, resulting in a higher demand for data storage, computational capacity, and real-time processing capabilities. Cloud computing has traditionally played an important role in establishing IoT. However, fog computing has recently emerged as a new field complementing cloud computing due to its enhanced mobility, location awareness, heterogeneity, scalability, low latency, and geographic distribution. However, IoT networks are vulnerable to unwanted assaults because of their open and shared nature. As a result, various fog computing-based security models that protect IoT networks have been developed. …

Genetic Analysis Of Heterogeneous Subsets Of Circulating Tumour Cells From High Grade Serous Ovarian Carcinoma Patients, Du-Bois Asante, Ganendra R. K. A. Mohan, Emmanuel Acheampong, Mel R. Ziman Dr, Leslie Calapre, Tarek M. Meniawy, Elin S. Gray, Aaron B. Beasley

Research outputs 2022 to 2026

Circulating tumour cells (CTCs) are heterogenous and contain genetic information from the tumour of origin. They bear specific intra- and extra-cellular protein markers aiding in their detection. However, since these markers may be shared with other rare cells in the blood, only genetic testing can confirm their malignancy. Herein, we analyse different CTC subsets using single cell whole genome DNA sequencing to validate their malignant origin. We randomly selected putative CTCs identified by immunostaining that were isolated from 4 patients with high grade serous ovarian cancer (HGSOC) and one with benign cystadenoma. We specifically targeted CTCs positive for epithelial (CK/EpCAM …

Novel Insights Into Potential Cannabis-Related Cancerogenesis From Recent Key Whole Epigenome Screen Of Cannabis Dependence And Withdrawal: Epidemiological Commentary And Explication Of Schrott Et Al., Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Whilst the cannabis-cancer link has been traditionally described as controversial recent whole nation and whole continent studies have demonstrated that well documented laboratory-based multimodal cannabinoid genotoxicity is indeed reflected in numerous cancer types in larger epidemiological series. A recent longitudinal human sperm epigenome-wide DNA methylation screen in both cannabis dependence and cannabis withdrawal has revealed remarkable insights into the manner in which widespread perturbations of DNA methylation may lead to cancerogenic changes in both the exposed and subsequent generations as a result of both cannabis exposure and withdrawal. These results therefore powerfully strengthen and further robustify the causal nature of …

Green Human Resource Management And Employee Innovative Behaviour: Does Inclusive Leadership Play A Role?, Azadeh Shafaei, Mehran Nejati

Research outputs 2022 to 2026

Purpose: This study examines the relationship between green human resource management (green HRM) and employee innovative behaviour. It also investigates the mediating role of job satisfaction to explore the mechanism through which green HRM is related to employee innovative behaviour. Additionally, it examines the moderating role of inclusive leadership to determine the boundary condition of the relationship between green HRM and employee innovative behaviour. Design/methodology/approach: The study used a quantitative research approach using survey and collected 508 responses from full-time employees in Australia. Findings: The authors have found support for all the hypothesised relationships in the study. Specifically, green HRM …

Gestational Age At Birth And Body Size From Infancy Through Adolescence: An Individual Participant Data Meta-Analysis On 253,810 Singletons In 16 Birth Cohort Studies, Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrøm, Thorkild I. A. Sørensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot De Moira, Barbara Heude, Carmen Iñiguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae Chi Huang, Rebecca C. Wilson, Sido Haakma, Sílvia Fernández-Barrés, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen

Research outputs 2022 to 2026

Background:

Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. We investigated the association of gestational age (GA) at birth with body size from infancy through adolescence.

Methods and Findings:

We conducted a two-stage individual participant data (IPD) meta-analysis using data from 253,810 mother-child dyads from 16 general population-based cohort …

A Feasibility, Safety, And Efficacy Evaluation Of Supervised Aerobic And Resistance Exercise For Patients With Glioblastoma Undertaking Adjuvant Chemoradiotherapy, Anna K. Nowak, Robert U. Newton, Travis Cruickshank, Prue Cormie, Georgia K. Halkett, Daphne Tsoi, Daniel A. Galvao

Research outputs 2022 to 2026

Background: While therapeutically effective, chemoradiotherapy treatment for high-grade glioma (glioblastoma) is often accompanied by side effects. Exercise has been demonstrated to alleviate the adverse effects of such treatments in other cancers. We aimed to evaluate the feasibility and preliminary efficacy of supervised exercise incorporating autoregulation. Methods: Thirty glioblastoma patients were recruited, five declined exercise and 25 were provided with a multimodal exercise intervention for the duration of their chemoradiotherapy treatment. Patient recruitment, retention, adherence to training sessions and safety were evaluated throughout the study. Physical function, body composition, fatigue, sleep quality, and quality of life were evaluated before and after …

Barriers And Enablers Associated With Participation In A Home-Based Pragmatic Exercise Snacking Program In Older Adults Delivered And Monitored By Amazon Alexa: A Qualitative Study, Paul Jansons, Jackson J. Fyfe, Jack Dalla Via, Robin M. Daly, David Scott

Research outputs 2022 to 2026

Background: ‘Exercise snacking’, which is characterised by shorter and more frequent exercise bouts compared with traditional exercise guidelines, may be an acceptable strategy for increasing physical activity and reducing sedentary behaviour in older adults. Aim: The aim of this study was to evaluate the enablers and barriers for older adults associated with participation in a home-based exercise snacking program delivered and monitored using an Amazon Echo Show 5 device (Alexa). Methods: This study used an interpretive description qualitative design to conduct semi-structured interviews following a 12-week pilot study in 15 adults aged 60–89 years with at least one chronic condition. …

Conceptualising Wellbeing For Australian Aboriginal Lgbtqa+ Young People, Shakara Liddelow-Hunt, Ashleigh Lin, James H. L. Hill, Kate Daglas, Braden Hill, Yael Perry, Mirella Wilson, Bep Uink

Research outputs 2022 to 2026

It is likely that young people who are both Aboriginal and Torres Strait Islander and LGBTQA+ would be at increased risk for poor mental health outcomes due to the layered impacts of discrimination they experience; however, there is very little empirical evidence focused on the mental health and wellbeing of Aboriginal and Torres Strait Islander LGBTQA+ young people. The current study represents a qualitative exploration of wellbeing among Aboriginal LGBTQA+ young people. This study consisted of semi-structured interviews and focus groups with Aboriginal LGBTQA+ young people aged 14–25 years old in the Perth metropolitan area of Western Australia. Thematic analysis …

Consumer Behavior Analysis On Sales Process Model Using Process Discovery Algorithm For The Omnichannel Distribution System, Ferra A. Tridalestari, Mustafid, Ferry Jie

Research outputs 2022 to 2026

Currently, Omnichannel distribution services are experiencing very rapid development around the world. In the Omnichannel distribution services, each existing sales channel will be connected to each other through integration capabilities so that no channels are left neglected. This is able to provide the best experience for consumers when shopping both online through mobile devices, laptops, and in physical stores. But on the other hand, this creates problems for business people who develop Omnichannel services. On the one hand, it facilitates the marketing process, but on the other hand, business people have difficultyreading the behavior of consumers who use Omnichannel distribution …

Instantaneous Frequency Estimation Of Fm Signals Under Gaussian And Symmetric Alpha-Stable Noise: Deep Learning Versus Time-Frequency Analysis, Huda Saleem Razzaq, Zahir M. Hussain

Research outputs 2022 to 2026

Deep learning (DL) and machine learning (ML) are widely used in many fields but rarely used in the frequency estimation (FE) and slope estimation (SE) of signals. Frequency and slope estimation for frequency-modulated (FM) and single-tone sinusoidal signals are essential in various applications, such as wireless communications, sound navigation and ranging (SONAR), and radio detection and ranging (RADAR) measurements. This work proposed a novel frequency estimation technique for instantaneous linear FM (LFM) sinusoidal wave using deep learning. Deep neural networks (DNN) and convolutional neural networks (CNN) are classes of artificial neural networks (ANNs) used for the frequency and slope estimation …

Policy Challenges And Responses To Environmental Non-Migration, Mostafa Mahmud Naser, Bishawjit Mallick, Rup Priodarshini, Saleemul Huq, Ajay Bailey

Research outputs 2022 to 2026

The scientific literature, media, international summits, and policy forums highlighted enough the people who either move or are willing to move because of environmental reasons. Still, the voluntary environmental non-migrants (ENM), who are assumed to have strong resilience and coping capacity, are inordinately overlooked. The importance of addressing these ENMs has increasingly been emphasised. First, the paper explains the characteristics of ENM, outlining the key distinction between voluntary and forced non-migrants. Second, it emphasises the need to protect populations affected by environmental change and disaster, specifically highlighting oft-neglected ENM policy gaps. Thus, it examines to what extent ENM is addressed …

The Definition Of A Community Paramedic: An International Consensus, Brendan Shannon, Sasch Baldry, Peter O'Meara, Nicole Foster, Angela Martin, Matthew Cook, Karen Stewart, Alecka Miles

Research outputs 2022 to 2026

Community paramedicine is a globally evolving model of care where paramedics provide community-based, preventative and primary healthcare services. With increased global interest and adaptation of the community paramedicine model, there is a lack of a clear definition of the role of a community paramedic. This study sought to come to an international consensus on the definition of a community paramedic. A four-phase Delphi methodology was utilised to achieve a global consensus on the definition of a community paramedic. A systematic approach to expert identification was performed and reported in line with the Conducting and REporting of DElphi Studies standard. A …

The Facilitators And Barriers To Exercise In The Noongar Aboriginal Population In Perth, Australia, Tuguy Esgin, Deborah Hersh, Kevin Rowley, Rona Macniven, Alan Crouch, Mark Halaki, Robert Newton

Research outputs 2022 to 2026

Indigenous Standpoint Theory forms the epistemological foundation for this study and methodological choices were made within this theoretical framework to ensure culturally responsive research processes that engaged the Indigenous agenda of self-determination and rights. The objectives of this research were to determine: (i) Indigenous perceptions of the facilitators and barriers to exercise; (ii) The potential feasibility and sustainability of an exercise intervention. In this context, Participatory Action Research methods were used to design the data-gathering instrument for the study—a questionnaire, co-designed with the Noongar Aboriginal community of Perth, Western Australia. This self-administered questionnaire, distributed to participants by email, post and …

Women’S Views On Obstetric Fistula Risk Factors And Prevention In North-Central Nigeria: An Interpretive Descriptive Study, Lydia Babatunde Bulndi, Deborah Ireson, Esther Adama, Sara Bayes

Research outputs 2022 to 2026

Objective: Obstetric fistula, also known as vesicovaginal fistula or rectovaginal fistula, is an abnormal opening between the vagina and rectum caused by prolonged obstructed labour that causes substantial long-term harm to women. It is most prevalent in low resource settings and although preventative measures have been proposed, they have not, to date, taken women’s own views into account. The objective of this study was to explore the views of North Nigerian women on obstetric fistula risk factors and prevention.

Design: This study was conducted using Interpretive Description methodology, which is a qualitative approach underpinned by Symbolic Interactionism. A semistructured questionnaire …

Heterogeneous Activation Of Persulfate By Macroscopic Nitrogen-Doped Graphene Oxide Cubes For The Degradation Of Antibiotic Contaminants In Water, Rajan A. K. Hirani, Abdul H. Asif, Nasir Rafique, Lei Shi, Shu Zhang, Martin Saunders, Wenjie Tian, Shaobin Wang, Hongqi Sun

Research outputs 2022 to 2026

As a sustainable and green approach, carbocatalysis, a metal-free strategy, has shown exceptional results in advanced oxidation processes (AOPs). Nonetheless, the recovery of these catalysts has been a major shortcoming over the years. Herein, three-dimensional nitrogen-doped graphene macrostructures (3D-NGMs), in the form of macro cubes, were synthesised by a simple cross-linking and thermal annealing procedure, after which they were employed in the activation of peroxydisulfate (PS) for the degradation of sulfamethoxazole (SMX). The catalytic cubes were loaded with different amounts of nitrogen precursor to investigate the role of nitrogen configuration in the sp2 hybridised carbon network on AOPs. NGC3 cubes …

Corrosion Behavior And Mechanisms Of The Heat-Treated Ti5cu Produced By Laser Powder Bed Fusion, Xin Wang, Peng Qin, L. Y. Chen, Hongqi Sun, Laichang Zhang

Research outputs 2022 to 2026

This work investigated the corrosion behavior of laser powder bed fusion produced (LPBFed) Ti5Cu and its heat-treated counterparts at 740 and 900 °C (named as HT-740 and HT-900 respectively) in Hank’s solution. The results indicated that the presence of acicular a'-Ti phase in LPBFed Ti5Cu was beneficial to corrosion, but the corrosion resistance of HT-740 and HT-900 were increased owing to the dual-phase microstructure (a'/a-Ti + Ti2Cu) or the increased content of Ti2Cu phase in the microstructure. The Ti2Cu phase could provide an ‘envelope’ protection to the a'/a-Ti phase and slow down the micro-galvanic reaction between a'/a-Ti phase and Ti2Cu …

Behind The Definition Of Industry 5.0: A Systematic Review Of Technologies, Principles, Components, And Values, Morteza Ghobakhloo, Mohammad Iranmanesh, Ming-Lang Tseng, Andrius Grybauskas, Alessandro Stefanini, Azlan Amran

Research outputs 2022 to 2026

This study addresses the emerging concept of Industry 5.0, which aims to tackle societal concerns associated with the ongoing digital industrial transformation. However, there is still a lack of consensus on the definition and scope of Industry 5.0, as well as limited understanding of its technological components, design principles, and intended values. To bridge these knowledge gaps, the study conducts a content-centric review of relevant literature and synthesizes evidence to develop an architectural design for Industry 5.0. The findings reveal that Industry 5.0 represents the future of industrial transformation, offering potential solutions to socio-economic and environmental issues that were inadequately …

Cancer Survivor Preferences For Models Of Breast Cancer Follow-Up Care: Selecting Attributes For Inclusion In A Discrete Choice Experiment, Sanjeewa Kularatna, Michelle Allen, Ruvini M. Hettiarachchi, Fiona Crawford-Williams, Sameera Senanayake, David Brain, Nicolas H. Hart, Bogda Koczwara, Carolyn Ee, Raymond J. Chan

Research outputs 2022 to 2026

Background and Objective: It is critical to evaluate cancer survivors’ preferences when developing follow-up care models to better address the needs of cancer survivors. This study was conducted to understand the key attributes of breast cancer follow-up care for use in a future discrete choice experiment (DCE) survey. Methods: Key attributes of breast cancer follow-up care models were generated using a multi-stage, mixed-methods approach. Focus group discussions were conducted with cancer survivors and clinicians to generate a range of attributes of current and ideal follow-up care. These attributes were then prioritised using an online survey with survivors and healthcare providers. …

Ctla4 Mrna Is Downregulated By Mir-155 In Regulatory T Cells, And Reduced Blood Ctla4 Levels Are Associated With Poor Prognosis In Metastatic Melanoma Patients, Prasanna Kumar Vaddi, Douglas Grant Osborne, Andrew Nicklawsky, Nazanin K. Williams, Dinoop Ravindran Menon, Derek Smith, Jonathan Mayer, Anna Reid, Joanne Domenico, Giang Huong Nguyen, William A. Robinson, Melanie Ziman, Dexiang Gao, Zili Zhai, Mayumi Fujita

Research outputs 2022 to 2026

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is an immune checkpoint expressed in regulatory T (Treg) cells and activated T lymphocytes. Despite its potential as a treatment strategy for melanoma, CTLA-4 inhibition has limited efficacy. Using data from The Cancer Genome Atlas (TCGA) melanoma database and another dataset, we found that decreased CTLA4 mRNA was associated with a poorer prognosis in metastatic melanoma. To investigate further, we measured blood CTLA4 mRNA in 273 whole-blood samples from an Australian cohort and found that it was lower in metastatic melanoma than in healthy controls and associated with worse patient survival. We confirmed these findings …

Development Of A Standardised System To Classify Injury-Inciting Circumstances In Football: The Football Injury Inciting Circumstances Classification System (Fiiccs), Francesco Aiello, Alan Mccall, Susan J. Brown, Andreas Serner, Lauren V. Fortington, Suzanne A. E. Huurman, Colin Lewin, Masashi Nagao, James O’Brien, Anastasia Panossian, Ricard Pruna, Guilherme P. Ramos, Matthew Whalan, Franco M. Impellizzeri

Research outputs 2022 to 2026

Background: A comprehensive examination of the sport-specific activities and circumstances being performed at the time of injury is important to hypothesise mechanisms, develop prevention strategies and inform future investigations. Results reported in the literature are inconsistent because inciting activities are reported using different classifications. Hence the aim was to develop a standardised system for the reporting of inciting circumstances. Methods: The system was developed using a modified Nominal Group Technique. The initial panel included 12 sports practitioners and researchers from four continents with respectively ≥ 5 years of experience working in professional football and/or conducting injury research. The process consisted …

Editorial: Computational Predictions, Dynamic Tracking, And Evolutionary Analysis Of Antibiotic Resistance Through The Mining Of Microbial Genomes And Metagenomic Data, Volume Ii, Qi Zhao, Jian Li, Alfred Tay, Liang Wang

Research outputs 2022 to 2026

Antibiotic resistance has emerged as a critical global health challenge, posing a significant threat to human and animal health. The rapid development of antibiotic resistance among pathogens has reduced the efficacy of existing treatments, leading to an urgent need for novel therapeutic strategies. One promising avenue of research involves mining microbial genomes and metagenomic data to uncover novel antimicrobial agents and a better understanding of the resistance mechanism.

Feasibility And Acceptability Of A Remotely Delivered Transdiagnostic Cbt Treatment For Postnatal Anxiety And Related Disorders: A Pilot Case Series, Peta N. Maguire, Navjot Bhullar, Suzanne M. Cosh, Bethany M. Wootton

Research outputs 2022 to 2026

Women in the postnatal period are at a high risk of developing clinically significant symptoms of anxiety. Cognitive behavioural therapy is effective in the treatment of postnatal anxiety; however, there are many barriers to accessing this treatment. This study examined the feasibility and acceptability of transdiagnostic cognitive behavioural therapy delivered remotely via Internet videoconferencing. Three women (Mage = 28.33 years; SD = 4.04) with a postnatal anxiety-related disorder were treated using the videoconference-delivered cognitive behavioural therapy. The treatment was delivered once per week over a 5-week period. All participants met criteria for clinically significant change in anxiety symptoms at post-treatment, …

Feasibility Meets Implementation Science: Narrowing The Research-To-Practice Gap For Exercise Activity In Multiple Sclerosis, James Smith, Onno Van Der Groen, Yvonne Learmonth

Research outputs 2022 to 2026

Background: There is a need to identify why multiple sclerosis exercise research is not translating into real-world participation. To lay the foundations of strong clinical research, considering the translational element of implementation science at the feasibility phase of a trial is vital. Methods: Document analysis was used to examine document sources on exercise activity interventions designed for people living with multiple sclerosis. Document sources focused on multiple sclerosis research that incorporated exercise prescription elements and behaviour change and were feasibility studies incorporating aspects of implementation science. Results: Implementation science should come much earlier than the efficacy or effectiveness research pipeline. …

Gender As A Moderator Of Spirituality And Spiritual Care In Icu Nurses During Covid-19 Pandemic, Ruqayya S. Zeilani, Ahmad M.R. Al-Qunneh, Diana H. Arabiat, Ayman Hamdan-Mansour

Research outputs 2022 to 2026

Background: Earlier research has found that female healthcare providers often report greater spirituality and spiritual care than males. This would evoke attention toward factors contributing to such differences, particularly gender. Aim: To examine the moderating effects of gender on the relationships between demographic characteristics of ICU nurses and their perceived spirituality and spiritual care. Methods: A cross-sectional correlational design was used to recruit a national sample of 865 nurses working in ICUs in Jordan and providing care to patients diagnosed with COVID-19. Data were collected using a self-report bilingual version of Spirituality and Spiritual Care Rating Scale (SSC) and analysed …

Levels Of Autotrophy And Heterotrophy In Mesophotic Corals Near The End Photic Zone, Amy Carmignani, Veronica Z. Radice, Kathryn M. Mcmahon, Alex I. Holman, Karen Miller, Kliti Grice, Zoe Richards

Research outputs 2022 to 2026

Mesophotic corals live at ~30-150 m depth and can sustain metabolic processes under light-limited conditions by enhancing autotrophy through specialized photoadaptations or increasing heterotrophic nutrient acquisition. These acclimatory processes are often species-specific, however mesophotic ecosystems are largely unexplored and acclimation limits for most species are unknown. This study examined mesophotic coral ecosystems using a remotely operated vehicle (Ashmore Reef, Western Australia at 40 – 75m depth) to investigate the trophic ecology of five species of scleractinian coral (from genera Leptoseris, Pachyseris, and Craterastrea) using stable isotope analyses (δ13C and δ15N) of host and symbiont tissues and protein concentration. Trophic strategies …

Economic Evaluation Of The Very Early Rehabilitation In Speech (Verse) Intervention, J. Kim, G. Sookram, Erin Godecke, Emily Louise Brogan, Elizabeth Armstrong, F. Ellery, T. Rai, M. L. Rose, Natalie Ciccone, S. Middleton, A. Holland, G. J. Hankey, J. Bernhardt, D. A. Cadilhac

Research outputs 2022 to 2026

Introduction: There is limited evidence on the costs and outcomes of patients with aphasia after stroke. The aim of this study was to estimate costs in patients with aphasia after stroke according to the aphasia therapies provided.

Methods: A three-arm, prospective, randomized, parallel group, open-label, blinded endpoint assessment trial conducted in Australia and New Zealand. Usual ward-based care (Usual Care) was compared to additional usual ward-based therapy (Usual Care Plus) and a prescribed and structured aphasia therapy program in addition to Usual Care (the VERSE intervention). Information about healthcare utilization and productivity were collected to estimate costs in Australian dollars …

Further Investigation Of Lead Exposure As A Potential Threatening Process For A Scavenging Marsupial Species, D. J. Hutchinson, E. M. Jones, J. M. Pay, J. R. Clarke, Michael T. Lohr, J. O. Hampton

Research outputs 2022 to 2026

There is a growing recognition of the harmful effects of lead exposure on avian and mammalian scavengers. This can lead to both lethal and non-lethal effects which may negatively impact wildlife populations. Our objective was to assess medium-term lead exposure in wild Tasmanian devils (Sarcophilus harrisii). Frozen liver samples (n = 41), opportunistically collected in 2017–2022, were analysed using inductively coupled plasma mass spectrometry (ICP-MS) to determine liver lead concentrations. These results were then used to calculate the proportion of animals with elevated lead levels ( > 5 mg/kg dry weight) and examine the role of explanatory variables that may have …

Physical Activity And Brain Amyloid Beta: A Longitudinal Analysis Of Cognitively Unimpaired Older Adults, Michael G. Slee, Stephanie R. Rainey-Smith, Victor L. Villemagne, James D. Doecke, Hamid R. Sohrabi, Kevin Taddei, David Ames, Vincent Dore, Paul Maruff, Simon M. Laws, Colin L. Masters, Christopher C. Rowe, Ralph N. Martins, Kirk I. Erickson, Belinda M. Brown

Research outputs 2022 to 2026

Introduction: The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (A ) over 15 years in a cohort of cognitively unimpaired older adults. Methods: PA and A measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain A . Moderation analyses examined apolipoprotein E (APOE) 4 carriage impact on the PA-A relationship. Results: PA was not associated with brain A at baseline ( = –0.001, p = 0.72) …

Aversive Reaction Between Disulfiram And Betel Quid Among Inpatients With Alcohol Use Disorder In Bhutan: A Preliminary Study, Ugyen Dem, Zimba Letho, Chencho Dorji, Damber K. Nirola, Sonam Choki, Tashi Dorji, Pelden Chejor

Research outputs 2022 to 2026

Betel Quid (BQ) is commonly used in the Asia-Pacific region. Disulfiram is prescribed for people with alcohol use disorders (PwAUDs) after the completion of detoxification as an alternative to rehabilitation. This prospective observational study reports the aversive reactions and common symptoms of Disulfiram and BQ in PwAUDs. Participants included PwAUDs admitted to the psychiatric ward at the Jigme Dorji Wangchuck National Referral Hospital for detoxification, who were on Disulfiram and using BQ at the same time. Aversive reactions between Disulfiram and BQ were observed for 100 patients over a year. Twenty participants showed aversive reactions between BQ and Disulfiram. Common …

Bidirectional Causality Between Immunoglobulin G N-Glycosylation And Metabolic Traits: A Mendelian Randomization Study, Xiaoni Meng, Weijie Cao, Di Liu, Isinta M. Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Research outputs 2022 to 2026

Although the association between immunoglobulin G (IgG) N-glycosylation and metabolic traits has been previously identified, the causal association between them remains unclear. In this work, we used Mendelian randomization (MR) analysis to integrate genome-wide association studies (GWASs) and quantitative trait loci (QTLs) data in order to investigate the bidirectional causal association of IgG N-glycosylation with metabolic traits. In the forward MR analysis, 59 (including nine putatively causal glycan peaks (GPs) for body mass index (BMI) (GP1, GP6, etc.) and seven for fasting plasma glucose (FPG) (GP1, GP5, etc.)) and 15 (including five putatively causal GPs for BMI (GP2, GP11, etc.) …