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Research outputs 2022 to 2026

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Impact Of Travel Time To Health Facilities On Perinatal Outcomes: A Systematic Review With Narrative Synthesis And Meta-Analysis, Sanam Roder-Dewan, Marwa Ramadan, Paul Ouma, Alexander Manu, Emelda A. Okiro, Natalie Strobel, Bibian N. Robert, Emily Odipo, Peter M. Macharia, Anthony Danso-Appiah, David C. Goodman, Queen Dube, Gagan Gupta, Hema Magge, Karen Edmond May 2026

Impact Of Travel Time To Health Facilities On Perinatal Outcomes: A Systematic Review With Narrative Synthesis And Meta-Analysis, Sanam Roder-Dewan, Marwa Ramadan, Paul Ouma, Alexander Manu, Emelda A. Okiro, Natalie Strobel, Bibian N. Robert, Emily Odipo, Peter M. Macharia, Anthony Danso-Appiah, David C. Goodman, Queen Dube, Gagan Gupta, Hema Magge, Karen Edmond

Research outputs 2022 to 2026

Background: Evidence-based global guidance on safe travel time for small or sick newborns who require transfer to health facilities after birth is lacking. A two-hour threshold is frequently cited in low- and middle-income countries (LMICs), while 30 minutes is commonly used in high-income countries (HICs). Although these thresholds are widely referenced, their empirical basis and consistency across levels of newborn care and journey types have not been systematically examined. This study synthesises the evidence linking travel time and perinatal outcomes. Methods: We conducted a systematic review with narrative synthesis and meta-analysis to assess the impact of travel time or distance …

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Adherence To The Eat-Lancet Diet And The Risk Of Heart Failure In Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Prospective Cohort Study, Peng Fu, Hong Zheng, Kuangyi Wu, Yulong Lan, Dan Wu, Weiqiang Wu, Huancong Zheng, Zefeng Cai, Yuxian Wang, Qiuyue Lin, Bo Zhang, Youren Chen May 2026

Adherence To The Eat-Lancet Diet And The Risk Of Heart Failure In Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Prospective Cohort Study, Peng Fu, Hong Zheng, Kuangyi Wu, Yulong Lan, Dan Wu, Weiqiang Wu, Huancong Zheng, Zefeng Cai, Yuxian Wang, Qiuyue Lin, Bo Zhang, Youren Chen

Research outputs 2022 to 2026

Background and objective – In 2019, the EAT-Lancet Commission on Healthy Diets from Sustainable Food Systems proposed the EAT-Lancet planetary health diet as a universal reference dietary pattern aimed at promoting human health while minimizing environmental degradation. However, epidemiological evidence regarding the association between adherence to the EAT-Lancet diet and the risk of heart failure (HF), particularly among individuals with cardiovascular-kidney-metabolic syndrome (CKMs) stages 0–3, remains limited. Therefore, this study aimed to examine the associations between adherence to the EAT-Lancet dietary pattern, its individual dietary components, and the risk of HF among individuals at CKMs stages 0–3. Materials and methods …

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Proteomics And Alkaloid Signature Of Narrow Leaf Lupin Leaves Reveal Key Enzymes In Quinolizidine Alkaloid Biosynthesis And Transportation, Tawfeek Khedr, Ling Ling Gao, Lars G. Kamphuis, Utpal Bose, Mitchell G. Nye-Wood, Angéla Juhász, Michelle L. Colgrave May 2026

Proteomics And Alkaloid Signature Of Narrow Leaf Lupin Leaves Reveal Key Enzymes In Quinolizidine Alkaloid Biosynthesis And Transportation, Tawfeek Khedr, Ling Ling Gao, Lars G. Kamphuis, Utpal Bose, Mitchell G. Nye-Wood, Angéla Juhász, Michelle L. Colgrave

Research outputs 2022 to 2026

Quinolizidine alkaloids (QAs) are toxic secondary metabolites in narrow-leafed lupin that defend against herbivores but constrain food and feed use. We developed a single-sample multiomics workflow for simultaneous extraction and quantitative analysis of QAs and proteins from individual leaves using urea/thiourea/CHAPS extraction with acetone precipitation, validated for QA quantification by LC–MS/MS. Data-independent acquisition proteomics of eight lupin accessions (four bitter, four sweet) identified 4437 proteins, with 183 differing significantly between bitter and sweet groups. Bitter accessions were enriched in lysine biosynthesis and stress-response pathways, whereas sweet accessions showed enrichment in phenylpropanoid and other defense-related processes. Coexpression network analysis linked protein …

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Growing Older Across Time And Space: The Impact Of Various Forms Of Capital On Social Support Networks Among Older Vietnamese Migrants, Hien Thi Nguyen, Lukasz Krzyzowski, Loretta Baldassar May 2026

Growing Older Across Time And Space: The Impact Of Various Forms Of Capital On Social Support Networks Among Older Vietnamese Migrants, Hien Thi Nguyen, Lukasz Krzyzowski, Loretta Baldassar

Research outputs 2022 to 2026

Much has been written about the important role of social support networks (SSNs) for the well-being of older adults, encompassing their social, emotional and practical needs. Less is known about what happens to the SSNs of older people when they migrate, and even fewer studies have examined the impact of different forms of capital on these networks. Drawing on ethnographic interviews and participant observation with 22 older Vietnamese migrants in Australia (2020–21), this paper explores the influence of different forms of social, cultural, economic and symbolic capital on their SSNs. Data analysis comprised egocentric social network analysis of the connections …

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A Generative Ai Method For Minority Class Handling In Anomaly Detection With Drift And Explainability Analysis, Kelvin J. Mwiga, Mussa A. Dida, Ahmad Mohsin, Iqbal H. Sarker May 2026

A Generative Ai Method For Minority Class Handling In Anomaly Detection With Drift And Explainability Analysis, Kelvin J. Mwiga, Mussa A. Dida, Ahmad Mohsin, Iqbal H. Sarker

Research outputs 2022 to 2026

Artificial Intelligence, particularly machine learning (ML) algorithms, plays a crucial role in detecting cyberattacks, including anomalies and intrusions. However, machine learning models trained on imbalanced cybersecurity datasets often struggle to accurately detect minority data instances and potential threats, thereby weakening overall system security. Despite extensive research, a persistent challenge is the inadequate explanation for model predictions concerning minority data classes. This study aims to address these limitations by developing a generative AI-based approach to manage minority classes in anomaly detection, incorporating concept drift handling and explainability analysis. We introduce an over-sampling technique, CGGReaT, designed to enhance the presence of minority …

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Maximal Motor Unit Firing Rates Decline With Amyotrophic Lateral Sclerosis Progression, Gabriel L. Fernandes, Lucas B.R. Orssatto, Matheus D. Pinto, Joao S. Henkin, Ehsan Shandiz, Pamela A. Mccombe, Robert D. Henderson, Gabriel S. Trajano May 2026

Maximal Motor Unit Firing Rates Decline With Amyotrophic Lateral Sclerosis Progression, Gabriel L. Fernandes, Lucas B.R. Orssatto, Matheus D. Pinto, Joao S. Henkin, Ehsan Shandiz, Pamela A. Mccombe, Robert D. Henderson, Gabriel S. Trajano

Research outputs 2022 to 2026

Objective: Amyotrophic lateral sclerosis (ALS) is characterised by progressive degeneration of upper and lower motor neurons and their motor units (MUs). MU loss is compensated by collateral sprouting and reinnervation of muscle fibres. There is limited information about the properties of these surviving MUs as these processes take place. High-density surface electromyography (HD-sEMG) decomposition enables non-invasive analysis of individual MU firing behaviour during maximal voluntary contractions and assess their changes with ALS progression. Methods: Thirty-nine individuals with ALS (24 men; mean age 63 ± 16 years) completed up to five visits (interval 20.0 ± 7.9 weeks). Tibialis anterior HD-sEMG recordings …

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International Evidence-Based Guidelines For Traditional Chinese Medicine Management Of Allergic Rhinitis, Qin-Wei Fu, Peng Liu, Yan Ruan, Xin-Rong Li, Lan-Zhi Zhang, Sha-Sha Yang, Feng Chai, Ji Chen, Qiao-Yan Chen, Shu-Cheng Chen, Wen-Yong Chen, Yong-Na Chen, Hong-Bin Cheng, Lei Cheng, Lu-Jia Cui, Ke-Bin Deng, Cai-Shan Fang, Rong-Chang Feng, Li Fu, Wen-Yang Fu, Jian-Ying Gao, Hong Guo, Miao He, Ko-Hsin Hu, Chun-Jiang Huang, He-Yin Huang, Lu-Yun Jiang, Feng-Ying Qiao, Hui Leng, Yun-Ying Li, Chun-Song Liu, Da-Xin Liu, Jian-Hua Liu, Jin-Hui Liu, Jing Liu, Min Liu, Weiting Liu, Yuan-Xian Liu, Yang Liu, Ying Liu, Zhi-Qing Liu, Qiu-Lan Luo, Yu Ma, De-Hong Mao, Juan Meng, Kai-Yun Pang, Shun-Lin Peng, Xuan-Fu Tong, Ji Wang, Jia-Xi Wang, Jun-Ge Wang, Ren-Zhong Wang, Shi-Zhen Wang, Ji-Yan Xia, Hui Xie, Qiang Xie, Yan Xie, Da-Jing Xiong, Zhan-Feng Yan, Hui Yang, Da-Zheng Zhang, Fu-Bing Zhang, Shi-Peng Zhang, Zhi-Cheng Zhang, Ji-Ping Zhao, Yu Zhao, Yun Zheng, Dan-Zhu Zhong, Li Zhou, Valentin Mikhailovich Knyazev, Irina Viktorovna Kostrova, Wing-Fai Yeung, Qi Wang, De-Yun Wang, Qin-Xiu Zhang May 2026

International Evidence-Based Guidelines For Traditional Chinese Medicine Management Of Allergic Rhinitis, Qin-Wei Fu, Peng Liu, Yan Ruan, Xin-Rong Li, Lan-Zhi Zhang, Sha-Sha Yang, Feng Chai, Ji Chen, Qiao-Yan Chen, Shu-Cheng Chen, Wen-Yong Chen, Yong-Na Chen, Hong-Bin Cheng, Lei Cheng, Lu-Jia Cui, Ke-Bin Deng, Cai-Shan Fang, Rong-Chang Feng, Li Fu, Wen-Yang Fu, Jian-Ying Gao, Hong Guo, Miao He, Ko-Hsin Hu, Chun-Jiang Huang, He-Yin Huang, Lu-Yun Jiang, Feng-Ying Qiao, Hui Leng, Yun-Ying Li, Chun-Song Liu, Da-Xin Liu, Jian-Hua Liu, Jin-Hui Liu, Jing Liu, Min Liu, Weiting Liu, Yuan-Xian Liu, Yang Liu, Ying Liu, Zhi-Qing Liu, Qiu-Lan Luo, Yu Ma, De-Hong Mao, Juan Meng, Kai-Yun Pang, Shun-Lin Peng, Xuan-Fu Tong, Ji Wang, Jia-Xi Wang, Jun-Ge Wang, Ren-Zhong Wang, Shi-Zhen Wang, Ji-Yan Xia, Hui Xie, Qiang Xie, Yan Xie, Da-Jing Xiong, Zhan-Feng Yan, Hui Yang, Da-Zheng Zhang, Fu-Bing Zhang, Shi-Peng Zhang, Zhi-Cheng Zhang, Ji-Ping Zhao, Yu Zhao, Yun Zheng, Dan-Zhu Zhong, Li Zhou, Valentin Mikhailovich Knyazev, Irina Viktorovna Kostrova, Wing-Fai Yeung, Qi Wang, De-Yun Wang, Qin-Xiu Zhang

Research outputs 2022 to 2026

Allergic rhinitis (AR) is a prevalent chronic condition that significantly impacts patients' quality of life and poses challenges to effective management. Traditional Chinese medicine (TCM) offers a holistic approach, emphasizing syndrome differentiation, individualized care, and natural treatment strategies. To develop comprehensive evidence-based guidelines for AR management using TCM interventions, incorporating rigorous evidence assessment and expert consensus. The guidelines were developed using the GRADE-TCM framework, analyzing 351 randomized controlled trials (RCTs) involving 43,276 participants. Supplementary evidence from published textbooks, standardized documents, ancient literature, and TCM medical records was incorporated. Five rounds of expert consensus, involving 80 expert person-times and over 10,000 …

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Low Climate Benefit Of Nordic Coastal Marshes: Site Conditions Outweigh Grazing Effects And Shape Trade-Offs Between Carbon Storage And Its Stability, Carmen Leiva-Dueñas, T. Banta, Christoffer Boström, Franziska Eller, Johan Eklöf, Line Holm Andersen, Kai Jensen, Marianna Lanari, Ella Logemann, Pere Masque, Thomas Ostertag, Christoph Reisdorff, Anaïs Richard, Anu Vehmaa, Jukka Alm, Mikael Von Numers, Dorte Krause-Jensen May 2026

Low Climate Benefit Of Nordic Coastal Marshes: Site Conditions Outweigh Grazing Effects And Shape Trade-Offs Between Carbon Storage And Its Stability, Carmen Leiva-Dueñas, T. Banta, Christoffer Boström, Franziska Eller, Johan Eklöf, Line Holm Andersen, Kai Jensen, Marianna Lanari, Ella Logemann, Pere Masque, Thomas Ostertag, Christoph Reisdorff, Anaïs Richard, Anu Vehmaa, Jukka Alm, Mikael Von Numers, Dorte Krause-Jensen

Research outputs 2022 to 2026

Coastal marshes, recognized as effective organic carbon (OC) sinks, have gained attention for their potential contribution to climate mitigation through protection and restoration. However, the climate mitigation potential of Nordic coastal marshes remains understudied, likely due to their heterogeneous and often non-tidal nature. To fill this gap, we examined soil OC storage and accumulation rates, and the effects of grazing, a common management practice, across eight Nordic coastal marsh areas spanning broad climate and environmental gradients. We also assessed soil methane emissions in selected areas. The Nordic marshes studied store a median of 7 kg OC m−2 (interquartile range, …

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Solvent-Dependent Proteome Profiling In Edible Mushrooms (Hypsizygus Marmoreus And Agaricus Bisporus), Tanvir Ahmed, O'Lone, Angéla Juhász, Utpal Bose, Kenneth U. Agbo, Netsanet Shiferaw Terefe, Michelle L. Colgrave May 2026

Solvent-Dependent Proteome Profiling In Edible Mushrooms (Hypsizygus Marmoreus And Agaricus Bisporus), Tanvir Ahmed, O'Lone, Angéla Juhász, Utpal Bose, Kenneth U. Agbo, Netsanet Shiferaw Terefe, Michelle L. Colgrave

Research outputs 2022 to 2026

This study compared five solvents - urea, carbonate-bicarbonate, citrate, phosphate, and water - for their ability to extract proteins from beech (BM) (Hypsizygus marmoreus) and Swiss brown (SB) (Agaricus bisporus) mushrooms. Using mass spectrometry-based proteomics and bioinformatics, we found that urea produced the highest total protein identifications by data-dependent acquisition at 1% false discovery rate (FDR): BM: 1739, SB: 1907; and by data-independent acquisition: BM: 1969, SB: 2172 proteins, especially enriching cytosolic and ribosomal proteins. Carbonate-bicarbonate favoured the extraction of metabolic and translational proteins, while citrate targeted extracellular and membrane-associated proteins related to cell wall dynamics. Phosphate-enriched catalytically active proteins, …

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Transitioning To Adolescent And Young Adult Or Adult Cancer Survivorship Care: A Systematic Review Of Contemporary Guidelines And Trials, Darren Haywood, Hammersley, Ursula Sansom-Daly, Jordana Mcloone, Evan Dauer, Helen Wilding, Nicolas H. Hart, Thomas Walwyn May 2026

Transitioning To Adolescent And Young Adult Or Adult Cancer Survivorship Care: A Systematic Review Of Contemporary Guidelines And Trials, Darren Haywood, Hammersley, Ursula Sansom-Daly, Jordana Mcloone, Evan Dauer, Helen Wilding, Nicolas H. Hart, Thomas Walwyn

Research outputs 2022 to 2026

Background: Health service transitions of child, adolescent, and young adult cancer survivors between paediatric and adult cancer care services are pervasively fragmented, resulting in poor coordination, reduced satisfaction, and adverse outcomes for cancer survivors and significant others (e.g., caregivers and family members). Numerous trials and clinical guidelines have been developed to support care transitions, but their convergence, divergence, and methodological quality remain unclear. To advance clinical practice and quality research about care transitions, a synthesis of trials and guidelines on child, adolescent, and young adult care transition across age-appropriate cancer services is required to inform future research, practice, guideline, and …

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Diversification For Stock Markets: Commodities Or Crypto, Mico Apostolov, Simone Domenico Scagnelli, Lorenzo Vasile May 2026

Diversification For Stock Markets: Commodities Or Crypto, Mico Apostolov, Simone Domenico Scagnelli, Lorenzo Vasile

Research outputs 2022 to 2026

The question that an asset could serve as a good store of value has been brought up a number of times, especially due to major market shocks. Despite the long-held belief that gold serves as a safe haven, a growing body of contemporary literature perpetually assesses this notion. Whether cryptocurrencies, namely Bitcoin as the most well-known of them, as an asset, can serve as a safe haven or hedge gains traction in research. This study investigates the relationship of gold and Bitcoin to S&P 500 stock index and the possibility that these might serve as a safe haven in respect …

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From Consumer-Centric Innovation To Sustainable Restaurant Performance: A Study Of Strategic Capability Integration In An Emerging Market Context, Juliana Juliana, Ira Brunchilda Hubner, Diena M. Lemy, Arifin Djakasaputra, Ferry Jie May 2026

From Consumer-Centric Innovation To Sustainable Restaurant Performance: A Study Of Strategic Capability Integration In An Emerging Market Context, Juliana Juliana, Ira Brunchilda Hubner, Diena M. Lemy, Arifin Djakasaputra, Ferry Jie

Research outputs 2022 to 2026

Increasing pressure for innovation-driven competitiveness requires hospitality firms to integrate technological capability, market intelligence, and customer-focused innovation into coherent strategic configurations. However, prior research has largely examined these capabilities separately, limiting understanding of how their integration influences restaurant marketing performance in emerging markets. This study develops and empirically tests an integrated capability framework linking techno-resonance innovation capability, competitor orientation, consumer-centric innovation strategy, and new service development to restaurant marketing performance using survey data from 300 restaurant managers in Java and Bali, Indonesia. The results of PLS-SEM analysis indicate that techno-resonance innovation capability significantly strengthens consumer-centric innovation strategy and new service …

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Medical Simulation In Toxicology: Enhancing Clinical Competence, Decision Making And Patient Care In Resource-Limited Settings, Rakesh Ghimire, Anjana Thapa, Sanjeev Kharel, Shristi Kharel Ghimire, Rabin Basnet, Farshad Mazda Shirazi, Allan J. Hamilton May 2026

Medical Simulation In Toxicology: Enhancing Clinical Competence, Decision Making And Patient Care In Resource-Limited Settings, Rakesh Ghimire, Anjana Thapa, Sanjeev Kharel, Shristi Kharel Ghimire, Rabin Basnet, Farshad Mazda Shirazi, Allan J. Hamilton

Research outputs 2022 to 2026

Medical simulation has emerged as a transformative approach in toxicology education. By providing immersive, hands-on experience, simulation enhances learner engagement, critical thinking, and long-term knowledge retention while offering a safe environment to practice clinical decision-making without jeopardizing patient safety. Despite these advantages, the integration of simulation-based training remains limited in low-and middle-income countries (LMICs) due to resource constraints, lack of standardized curricula, and limited access to high-fidelity simulators. Additionally, little research has explored its optimal application in these settings. This review explores available evidence regarding the effectiveness of medical simulation in the diagnosis and treatment of toxicological emergencies in LMICs. …

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How Employment-Based Clinical Experience During Undergraduate Education Influences Transition To Practice: A Qualitative Systematic Review, Seung A. Park, Marion Eckert, Rebecca Sharp, Belinda Clark, Micah D.J. Peters May 2026

How Employment-Based Clinical Experience During Undergraduate Education Influences Transition To Practice: A Qualitative Systematic Review, Seung A. Park, Marion Eckert, Rebecca Sharp, Belinda Clark, Micah D.J. Peters

Research outputs 2022 to 2026

Aim: To synthesize qualitative evidence on the experiences of undergraduate nursing students and new graduate nurses engaged in formal paid employment models or health-related work during their undergraduate studies, to examine how these employment-based clinical experiences influence their transition to nursing practice, and to identify elements that facilitate or hinder this transition. Design: Qualitative systematic review. Methods: Searches were conducted in MEDLINE, Embase, Emcare (Ovid), CINAHL Complete (EBSCOhost), ERIC (ProQuest), and gray literature sources, including ProQuest Dissertations and Theses and Google Scholar. No date or country limits were applied, although only English-language studies were included. The review followed JBI methodology …

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Recovery Timeframe Is A Critical Component In Preserving Carbon Stocks In Disturbed Tropical Seagrass Meadows, Taylor Renee Condron, Timothy M. Smith, Paul H. York, Nicholas J. Murray, Pere Masque, Michael A. Rasheed May 2026

Recovery Timeframe Is A Critical Component In Preserving Carbon Stocks In Disturbed Tropical Seagrass Meadows, Taylor Renee Condron, Timothy M. Smith, Paul H. York, Nicholas J. Murray, Pere Masque, Michael A. Rasheed

Research outputs 2022 to 2026

Seagrass meadows, though covering a small percentage of the ocean floor, play a critical role in marine carbon sequestration. However, the mechanisms behind this role remain uncertain due to challenges in mapping seagrass extent and flux, accounting for spatial variation in carbon storage, and incorporating site-specific histories. This study investigates the effects of short-term (≤10 years) seagrass loss on sediment carbon stocks within a large seagrass meadow in the Great Barrier Reef region. Using remote sensing data to construct a seagrass recovery timeline, combined with field sampling and assessments of ecological factors, we found higher sediment organic carbon in areas …

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Role Of Directional Conditional Filtering On Droplet Velocity And Size Distribution, Farzad Hossain, Matthew J. Cleary, Yasir M. Al-Abdeli, Mehdi Khiadani May 2026

Role Of Directional Conditional Filtering On Droplet Velocity And Size Distribution, Farzad Hossain, Matthew J. Cleary, Yasir M. Al-Abdeli, Mehdi Khiadani

Research outputs 2022 to 2026

This study investigates the role of directional filtering in the analysis of spray behaviour using two full cone nozzles (65° and 75°) emitting aqueous sprays under atmospheric conditions. A hybrid computational–experimental framework was applied, using Large Eddy Simulation (LES) with Discrete Phase Model (DPM) and Rosin-Rammler distribution in ANSYS Fluent, validated against Shadowgraph and Particle Image Velocimetry (PIV) measurements. The sensitivity of directional filtering to the effects of spray angle and flow rate (1.75 and 3.5 L/min), were also done. Upward-filtered droplets consistently exhibited greater breakup than both raw and downward-filtered data due to gravitational opposition and longer air exposure. …

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A Comparison Of Treadmill Preferred Walking Speed Assessments: Reliability Of Common Protocols And The Novel Treadpws Test, Kirsty A. Mcdonald, Ella Li, John Kerr, Jessica C. Selinger, Kimberley S. Van Schooten May 2026

A Comparison Of Treadmill Preferred Walking Speed Assessments: Reliability Of Common Protocols And The Novel Treadpws Test, Kirsty A. Mcdonald, Ella Li, John Kerr, Jessica C. Selinger, Kimberley S. Van Schooten

Research outputs 2022 to 2026

Background: Human locomotion studies often require participants to self-select a preferred walking speed (PWS), yet there is no consensus or standard protocol for determining this speed. We developed a new protocol to determine PWS (TreadPWS Test). Research question: We compared the TreadPWS Test to three other common protocols in the literature (Dingwell PWS Test, Jordan PWS Test, Dal PWS Test) across a range of reliability and implementation metrics. Methods: Healthy participants (N = 20) attended two sessions within a seven-day period, during which a PWS was determined using each protocol. One test (Dal PWS Test) was conducted overground, and the …

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Dynamic Mechanical Insertion Analysis Of Gelatin Methacryloyl Microneedles Under Realistic Insertion Conditions, Moloud Amini Baghbadorani, Masoumeh Zargar, Abdellah Shafieian, Majid Tolouei-Rad May 2026

Dynamic Mechanical Insertion Analysis Of Gelatin Methacryloyl Microneedles Under Realistic Insertion Conditions, Moloud Amini Baghbadorani, Masoumeh Zargar, Abdellah Shafieian, Majid Tolouei-Rad

Research outputs 2022 to 2026

Despite the great potential of Gelatin Methacryloyl (GelMA) microneedles (MNs) for minimally invasive drug delivery and interstitial fluid extraction, their performance under realistic insertion conditions and across diverse geometrical and mechanical parameters has remained uncharacterized. In this study, dynamic and static finite-element analyses were conducted for the first time to compare three types of crosslinked GelMA MNs: conical, pyramidal, and tapered-conical with and without base support. Insertion force, von Mises stress, and safety factors were evaluated at insertion velocities of 2-6 m/s under varying crosslinking times and polymer concentrations. The tapered-conical geometry demonstrated the best overall mechanical reliability, combining moderate …

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Prevention Of Dementia Using Mobile Phone Applications (Prodemos) – A Health-Economic Cost-Utility Analysis In People Aged 55–75 Years With Low Socio-Economic Status, Ron Handels, Marieke Hoevenaar-Blom, Manshu Song, Carol Brayne, Eric Moll Van Charante, Fiona E. Matthews, Junfang Xu, Linus Jönsson, Nicola Coley, Rachael Brooks, Xuening Jian, Tingting Qin, Youxin Wang, Wei Wang, Edo Richard, Anders Wimo May 2026

Prevention Of Dementia Using Mobile Phone Applications (Prodemos) – A Health-Economic Cost-Utility Analysis In People Aged 55–75 Years With Low Socio-Economic Status, Ron Handels, Marieke Hoevenaar-Blom, Manshu Song, Carol Brayne, Eric Moll Van Charante, Fiona E. Matthews, Junfang Xu, Linus Jönsson, Nicola Coley, Rachael Brooks, Xuening Jian, Tingting Qin, Youxin Wang, Wei Wang, Edo Richard, Anders Wimo

Research outputs 2022 to 2026

Introduction We aimed to explore the potential incremental cost-effectiveness of the PRODEMOS coach-supported mobile health intervention for primary prevention of dementia versus standard of care provided to people aged 55–75 years with low socio-economic status (SES) in the United Kingdom (UK), and any SES in China. Methods 12–18-month PRODEMOS trial (ISRCTN15986016) efficacy outcomes on hypertension, obesity, hypercholesterolemia, physical inactivity and smoking were extrapolated to lifetime impact on dementia onset, myocardial infarction, stroke and death using a health-economic open-source simulation model. Results Simulated outcomes showed dementia cases were avoided (UK = -206 (-658 to 281), China = -140 (-456 to 205) …

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3d-Printed Cf-Pla Bone Plates With Metamaterial Structures: Design, Fabrication, And Mechanical Evaluation, Ani Daniel, Hamed Bakhtiari, Alireza Nouri, Barun K. Das, Muhammad Aamir, Majid Tolouei-Rad May 2026

3d-Printed Cf-Pla Bone Plates With Metamaterial Structures: Design, Fabrication, And Mechanical Evaluation, Ani Daniel, Hamed Bakhtiari, Alireza Nouri, Barun K. Das, Muhammad Aamir, Majid Tolouei-Rad

Research outputs 2022 to 2026

This study presents the design, fabrication, and mechanical performance of carbon fiber-reinforced polylactic acid (CF-PLA) bone plates incorporating auxetic and non-auxetic metamaterial architectures. Four lattice-structured bone plates (re-entrant, rotating square, tetrachiral, and hexagonal) were evaluated for their flexural, tensile, and compressive properties. The specimens were fabricated using Fused Deposition Modelling (FDM). The tetrachiral structure demonstrated superior bending capacity, achieving a flexural stress of 17 MPa and a modulus of 1214 MPa. Under both tension and compression, it exhibited the highest strength (24.5 MPa and 40 MPa, respectively) and stiffness (1441 MPa in tension and 2352 MPa in compression), while the …

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A Clinical Study Examining The Effects Of Dietary Nitrate On Urinary N-Nitrosamines, Catherine P. Bondonno, Michaela L. Sundqvist, Sujata Shinde, Kevin Croft, Jonathan M. Hodgson, Mattias Carlström, Eddie Weitzberg, Jon O. Lundberg May 2026

A Clinical Study Examining The Effects Of Dietary Nitrate On Urinary N-Nitrosamines, Catherine P. Bondonno, Michaela L. Sundqvist, Sujata Shinde, Kevin Croft, Jonathan M. Hodgson, Mattias Carlström, Eddie Weitzberg, Jon O. Lundberg

Research outputs 2022 to 2026

BackgroundInorganic nitrate from dietary sources has raised health concerns due to its possible conversion into carcinogenic N-nitrosamines, leading to strict regulations on nitrate concentrations in food and drinking water.ObjectivesIn this study, which was a part of a larger randomized controlled trial, we evaluated urinary excretion of N-nitrosamines in response to daily dietary nitrate intake over a 5-wk period using 2 different forms of nitrate administration.MethodsA total of 231 participants with mild hypertension were randomly assigned into 3 groups. Group 1 (n = 78) consumed vegetables low in nitrate along with a placebo capsule (300 mg potassium chloride). Group 2 (n …

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A Survey Of Privacy-Preserving Federated Learning For Intrusion Detection Systems, Thomas Bunko, Michael N. Johnstone, Wencheng Yang, Ben A. Scott May 2026

A Survey Of Privacy-Preserving Federated Learning For Intrusion Detection Systems, Thomas Bunko, Michael N. Johnstone, Wencheng Yang, Ben A. Scott

Research outputs 2022 to 2026

Intrusion detection systems (IDS) monitor and detect malicious activity and unauthorized access that may compromise systems. Traditional IDS approaches send data to a central server for analysis, raising privacy concerns as data owners lose control over security. Federated Learning (FL) offers a privacy-preserving alternative by allowing local devices to process their data and generate models without sharing raw data. These local models are aggregated centrally to form a comprehensive model with performance comparable to centralized systems. This paper reviews FL-based IDS research, and is the first review paper to focus on privacy-preserving techniques collectively known as privacy-preserving Federated Learning (PPFL) …

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Associations Between Source-Specific Nitrate And Nitrite Intakes And Metabolic Dysfunction-Associated Steatotic Liver Disease In Two Prospective Cohorts, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Liezhou Zhong, Dorit W. Erichsen, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Alysha S. Thompson, Tilman Kühn, Aedín Cassidy, Anja Olsen, Catherine P. Bondonno May 2026

Associations Between Source-Specific Nitrate And Nitrite Intakes And Metabolic Dysfunction-Associated Steatotic Liver Disease In Two Prospective Cohorts, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Liezhou Zhong, Dorit W. Erichsen, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Alysha S. Thompson, Tilman Kühn, Aedín Cassidy, Anja Olsen, Catherine P. Bondonno

Research outputs 2022 to 2026

SummaryBackground and AimsDietary nitrate and nitrite may have source-dependent effects on liver health: plant-sourced nitrate may confer hepatoprotective benefits via its conversion to nitric oxide, whereas nitrate and nitrite from animal foods, processed meats, or contaminated drinking water may promote liver injury via their conversion to N-nitrosamines. We aimed to examine associations between source-specific nitrate and nitrite intakes and incident metabolic dysfunction-associated steatotic liver disease (MASLD) in two large cohorts. Secondary aims were to assess associations with liver MRI biomarkers and to evaluate whether nitric oxide-pathway gene variants modify associations with plant-sourced nitrate/nitrite.MethodsWe analysed 53,854 participants from the Danish Diet, …

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Key Insights From The International Icu Diary Conference 2025, Peter Nydahl, Bev Ewens, Anne Sophie Debue, Xavier Fiorilla, Kristin Gabriel, Alessandro Galazzi, Louise Gallie, Nikolas Groth, Carly Hickey, Mark Hudson, Fiona Lynch, Nicola Maxwell, Margo Van Mol, Caroline Renner, Louise Rose, Kate Tantam, Lioudmila Karnatovskaia, Christina Jones May 2026

Key Insights From The International Icu Diary Conference 2025, Peter Nydahl, Bev Ewens, Anne Sophie Debue, Xavier Fiorilla, Kristin Gabriel, Alessandro Galazzi, Louise Gallie, Nikolas Groth, Carly Hickey, Mark Hudson, Fiona Lynch, Nicola Maxwell, Margo Van Mol, Caroline Renner, Louise Rose, Kate Tantam, Lioudmila Karnatovskaia, Christina Jones

Research outputs 2022 to 2026

We report on the 2025 International ICU Diary Conference that provided a comprehensive update on current knowledge, innovations and global practices related to ICU diaries. Held in a 6-week online format, the event featured 23 speakers and was attended by mean 69.7 (SD 20.5) participants per session. Topics included development of ICU diaries, use in special settings, digital diaries, survivors' and families' experiences, Post-Intensive-Care Syndrome and follow-up and implementation projects. Highlights were innovative solutions for digital diaries and the report of persons with lived and living experiences with diaries, changing the focus on humanising critical care. Relevance for Practice: ICU …

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A Systematic Review And Meta-Analysis On The Levels Of Supportive Care Needs In Adults With Cancer, Caroline B. Silveira, Rech, Maria Petropoulou, Pietro S. Rössler, Francine F. De Souza, Helena B. Böhmer, Amanda L. Giacomet, Richard Alejandro B. De Barros, Lucélia De C. De Barros, Vagner R.Z.B. Pereira, Nanci Da S.T. Junqueira, Pedro Lopez May 2026

A Systematic Review And Meta-Analysis On The Levels Of Supportive Care Needs In Adults With Cancer, Caroline B. Silveira, Rech, Maria Petropoulou, Pietro S. Rössler, Francine F. De Souza, Helena B. Böhmer, Amanda L. Giacomet, Richard Alejandro B. De Barros, Lucélia De C. De Barros, Vagner R.Z.B. Pereira, Nanci Da S.T. Junqueira, Pedro Lopez

Research outputs 2022 to 2026

Objective: To estimate the levels of supportive care needs among adults with cancer using the Supportive Care Needs Survey–Short Form 34 (SCNS-SF34) and to examine demographic, clinical, and treatment-related determinants. Methods: A systematic review and meta-analysis was conducted (CRD42024604977). Studies reporting SCNS-SF34 scores in adults with cancer were included. Searches were performed across six different databases (November 2024; updated August 2025). Random-effects meta-analyses were undertaken to estimate the pooled mean scores across the five SCNS-SF34 domains and total score. Subgroup and meta-regression analyses explored potential determinants. Results: Ninety-five studies (n = 32,493) were analysed. The unmet needs observed tended to …

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Dynamic Load Assessment Of Pem Fuel Cell Systems Under Pid-Based Control Strategies For Sustainable Operation, Tarek Abedin, Paw, Normy Norfiza Abdul Razak, Chen Chai Phing, Yaw Chong Tak, Monowar Mahmud, Manzoore Elahi M. Soudagar, T. M. Yunus Khan, Mohammad Tariqul Islam, Mohammad Nur-E-Alam May 2026

Dynamic Load Assessment Of Pem Fuel Cell Systems Under Pid-Based Control Strategies For Sustainable Operation, Tarek Abedin, Paw, Normy Norfiza Abdul Razak, Chen Chai Phing, Yaw Chong Tak, Monowar Mahmud, Manzoore Elahi M. Soudagar, T. M. Yunus Khan, Mohammad Tariqul Islam, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

Proton exchange membrane fuel cell (PEMFC) systems’ reliable operation under variable load conditions is a significant challenge because of voltage fluctuations, transient variations, and the high computational requirements of sophisticated control techniques like intelligent and model predictive controllers. Even while these state-of-the-art methods provide great precision, complexity and cost often limit their real-time applicability, underscoring the need for a simpler but efficient control solution. To achieve effective voltage regulation in PEMFC systems, this study suggests a DC–DC buck converter in conjunction with a comparator-based proportional–integral–derivative (PID) control technique. In order to provide stable operation under both constant and changing load …

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The Rise And Fall Of The World's Greatest Marine Biodiversity Hotspot, Alexandre C. Siqueira, Kiessling, Nussaïbah Raja, David R. Bellwood May 2026

The Rise And Fall Of The World's Greatest Marine Biodiversity Hotspot, Alexandre C. Siqueira, Kiessling, Nussaïbah Raja, David R. Bellwood

Research outputs 2022 to 2026

Habitat condition and area shape global species distributions, with shallow-water reefs hosting a disproportional share of marine biodiversity. Although reef area is a well-established predictor of marine species richness, its historical context is less well understood. Here, we show that the rise of tropical marine biodiversity is closely tied to reef expansion in space and time. During the Early/Mid Miocene (23 to 11.6 million years ago), Indo-Pacific reefs reached unprecedented size and thickness, surpassing any reef systems in the past 66 million years. These massive reefs, likely driven by unique environmental, biotic, and tectonic conditions, fostered the expanding diversity and …

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A High-Throughput Assay For Monitoring And Quantifying Amyloid-Β Accumulation And Clearance In Alzheimer's Disease Cell Models, Ajish Ariyath, Fraulein Denise Arigo, Anna Fyfe, W. M.A.D.Binosha Fernando, Ralph Martins, Prashant Bharadwaj May 2026

A High-Throughput Assay For Monitoring And Quantifying Amyloid-Β Accumulation And Clearance In Alzheimer's Disease Cell Models, Ajish Ariyath, Fraulein Denise Arigo, Anna Fyfe, W. M.A.D.Binosha Fernando, Ralph Martins, Prashant Bharadwaj

Research outputs 2022 to 2026

Amyloidogenic proteins, such as amyloid-β (Aβ), self-assemble into cross-β fibrils whose accumulation is central to Alzheimer's disease (AD). Measuring Aβ aggregation and clearance in living cells remains challenging using current cell-based assays, which are often low-throughput or not suited for real-time monitoring. This study aimed to (1) develop a robust, quantitative, and scalable fluorescence-based assay using Amytracker to monitor Aβ accumulation and clearance in an Aβ-producing neuronal cell model, and (2) validate its utility for mechanistic studies and therapeutic screening. We established a plate-based fluorescence assay using Amytracker in MC65 neuronal AD model expressing the Amyloid precursor protein C-terminal fragment …

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Between-Session Reliability And Sensitivity Of Force Production Characteristics Across Various Force-Time Points During The Isometric Single-Leg Long-Lever Bridge, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort May 2026

Between-Session Reliability And Sensitivity Of Force Production Characteristics Across Various Force-Time Points During The Isometric Single-Leg Long-Lever Bridge, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort

Research outputs 2022 to 2026

The purpose of this study was to assess the between-session reliability of peak force and early force-time variables in a unilateral isometric hamstring assessment (isometric long-lever bridge). The sample consisted of 30 collegiate male athletes (age: 19.4±1.3 years; height: 1.79±0.1 m; body mass: 80.4±10.3 kg) with no history of recent hamstring injury (<6 months) who volunteered to participate in the study. All participants performed 3 unilateral maximal voluntary isometric contractions (MVIC) with their heels on force plates and shoulders elevated 15.24 cm, while their hips were secured with a loaded barbell. Data was analyzed to assess the reliability of force values at 50, 100, 150, 200, 250 ms, and peak force (N) across three repeated sessions. Moderate-good relative and absolute reliabilities were observed across all early force-time variables with lower bound ICC values≥0.51 (0.51–0.71) and point estimate CV%≤12.65% (7.63–12.65), with moderate relative (ICC≥0.74; range 0.74–0.92) and absolute (CV%≤6.50%; range 6.48–6.50) reliability for peak force. Trivial to small effect sizes (g≤0.4) were observed between sessions. These findings suggest that the isometric single-leg long-lever bridge (SL-LLB) can be used to reliably monitor peak and rapid force generating capacities to track performance changes over time due to training adaptations as well as acute or chronic fatigue.

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Beyond The First Bout: Adaptations To Repeated Injuries Across Physiological And Pathological Conditions, Cory W. Baumann, Christopher P. Ingalls, Kazunori Nosaka, Jarrod A. Call May 2026

Beyond The First Bout: Adaptations To Repeated Injuries Across Physiological And Pathological Conditions, Cory W. Baumann, Christopher P. Ingalls, Kazunori Nosaka, Jarrod A. Call

Research outputs 2022 to 2026

Skeletal muscle exhibits remarkable plasticity following injury, yet most research has focused on responses to a single bout of eccentric contractions. This review addresses adaptations to repeated eccentric contraction–induced injuries across physiological and pathological conditions, with emphasis on insights from preclinical rodent models. In healthy muscle, the repeated bout effect (RBE) reduces strength loss and accelerates recovery after subsequent bouts. However, these adaptations are highly condition dependent. Aging can attenuate the RBE, while dystrophic muscle remains vulnerable to repeated injury despite compensatory remodeling. Other factors, including but not limited to, chronic alcohol intake and malignant hyperthermia can influence these responses, …

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