Digital Commons Network^™

When And Why Consumers Choose Supersized Food?, Asim Qazi, Veronique Cova, Shahid Hussain, Ubedullah Khoso

Research outputs 2022 to 2026

Purpose:

This study aims to achieve three objectives: to explore the perception of consumers about supersized foods (in both pre- and post-consumption scenarios), to identify why consumers prefer supersized options over other available options and to determine the types of situations that push consumers to make such decisions.

Design/methodology/approach:

This qualitative study uses the triangulation of projective methods, coupled with semi-structured interviews with 120 participants. The data was collected from major cities of Pakistan, using a convenient sample of 25 semi-structured interviews, 35 narratives and 60 sentence completions and constructions analyzed by performing thematic analysis.

Findings:

The findings indicate that …

Abdominal Aortic Calcification On Lateral Spine Images Captured During Bone Density Testing And Late-Life Dementia Risk In Older Women: A Prospective Cohort Study, Tenielle Porter, Marc Sim, Richard L. Prince, John T. Schousboe, Catherine Bondonno, Wai H. Lim, Kun Zhu, Douglas P. Kiel, Jonathan M. Hodgson, Simon M. Laws, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Dementia after the age of 80 years (late-life) is increasingly common due to vascular and non-vascular risk factors. Identifying individuals at higher risk of late-life dementia remains a global priority. Methods: In prospective study of 958 ambulant community-dwelling older women ( ≥ 70 years), lateral spine images (LSI) captured in 1998 (baseline) from a bone density machine were used to assess abdominal aortic calcification (AAC). AAC was classified into established categories (low, moderate and extensive). Cardiovascular risk factors and apolipoprotein E (APOE) genotyping were evaluated. Incident 14.5-year late-life dementia was identified from linked hospital and mortality records. Findings: At …

Moderate Increase Of Serum Uric Acid Within A Normal Range Is Associated With Improved Cognitive Function In A Non-Normotensive Population: A Nationally Representative Cohort Study, Jinqi Wang, Rui Jin, Zhiyuan Wu, Yueruijing Liu, Xiaohan Jin, Ze Han, Yue Liu, Zongkai Xu, Xiuhua Guo, Lixin Tao

Research outputs 2022 to 2026

Background: Associations between serum uric acid (SUA) and changes in cognitive function are understudied in non-normotensive populations, and many previous studies only considered the baseline SUA at a single time point. We aimed to examine the effects of baseline SUA and 4-year changes in SUA on cognitive changes in the non-normotensive population. Materials and methods : In the China Health and Retirement Longitudinal Study (CHARLS), cognitive function was measured based on executive function and episodic memory in four visits (years: 2011, 2013, 2015, and 2018). We identified two study cohorts from CHARLS. The first cohort included 3,905 non-normotensive participants. Group-based …

Proteome Phenotypes Discriminate The Growing Location And Malting Traits In Field-Grown Barley, Mahya Bahmani, Angéla Juhász, James Broadbent, Utpal Bose, Mitchell G. Nye-Wood, Ian B. Edwards, Michelle L. Colgrave

Research outputs 2022 to 2026

Barley is one of the key cereal grains for malting and brewing industries. However, climate variability and unprecedented weather events can impact barley yield and end-product quality. The genetic background and environmental conditions are key factors in defining the barley proteome content and malting characteristics. Here, we measure the barley proteome and malting characteristics of three barley lines grown in Western Australia, differing in genetic background and growing location, by applying liquid chromatography-mass spectrometry (LC-MS). Using data-dependent acquisition LC-MS, 1571 proteins were detected with high confidence. Quantitative data acquired using sequential window acquisition of all theoretical (SWATH) MS on barley …

Effects Of Various Solvents On Adsorption Of Organics For Porous And Nonporous Quartz Co2 Brine Systems: Implications For Co2 Geo-Storage, Muhammad Ali, Nurudeen Yekeen, Mujahid Ali, Mirhasan Hosseini, Nilanjan Pal, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit

Research outputs 2022 to 2026

The underground geo-storage of carbon dioxide (CO₂) is an essential component of the carbon capture and sequestration value chain. The success of CO₂ containment depends on the wetting state of the rock, which controls the mechanism of fluid flow and distribution. The presence of organic acids in the storage formation introduces a considerable effect on the wettability of the rock / CO₂ / brine system under various temperature and pressure conditions. Despite the previous studies on this topic, the impact of the substrate pores, the rock surface roughness, and the solvents used to prepare the organic …

Metabolomics Reveals Mouse Plasma Metabolite Responses To Acute Exercise And Effects Of Disrupting Ampk-Glycogen Interactions, Mehdi R. Belhaj, Nathan G. Lawler, John A. Hawley, David I. Broadhurst, Nolan J. Hoffman, Stacey N. Reinke

Research outputs 2022 to 2026

Introduction: The AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis that becomes activated by exercise and binds glycogen, an important energy store required to meet exercise-induced energy demands. Disruption of AMPK-glycogen interactions in mice reduces exercise capacity and impairs whole-body metabolism. However, the mechanisms underlying these phenotypic effects at rest and following exercise are unknown. Furthermore, the plasma metabolite responses to an acute exercise challenge in mice remain largely uncharacterized. Methods : Plasma samples were collected from wild type (WT) and AMPK double knock-in (DKI) mice with disrupted AMPK-glycogen binding at rest and following 30-min submaximal treadmill …

Digestibility Of Wheat Alpha-Amylase/Trypsin Inhibitors Using A Caricain Digestive Supplement, Angéla Juhász, Mitchell G. Nye-Wood, Gregory J. Tanner, Michelle L. Colgrave

Research outputs 2022 to 2026

Wheat is a major source of nutrition, though in susceptible people it can elicit inappropriate immune responses. Wheat allergy and non-celiac wheat sensitivity are caused by various wheat proteins, including alpha-amylase trypsin inhibitors (ATIs). These proteins, like the gluten proteins which can cause celiac disease, are incompletely digested in the stomach such that immunogenic epitopes reach the lower digestive system where they elicit the undesirable immune response. The only completely effective treatment for these immune reactions is to eliminate the food trigger from the diet, though inadvertent or accidental consumption can still cause debilitating symptoms in susceptible people. One approach …

Saliva Cortisol Diurnal Variation And Stress Responses In Term And Preterm Infants, David Q. Stoye, James P. Boardman, Clive Osmond, Gemma Sullivan, Gillian Lamb, Gill S. Black, Natalie Z. M. Homer, Nina Nelson, Elvar Theodorsson, Evalotte Mörelius, Rebecca M. Reynolds

Research outputs 2022 to 2026

Objective:

To determine if preterm birth is associated with adaptation of the hypothalamic–pituitary–adrenal (HPA) axis and whether HPA axis programming relates to the degree of prematurity (defined as extremely preterm birth at < 28 weeks or very preterm birth at 28–32 weeks gestation).

Design:

This study reports findings from a prospective birth cohort. Saliva cortisol concentrations were measured prevaccination and postvaccination, and in the morning and evening, at 4 months chronological age.

Setting:

Infants born at a single Scottish hospital.

Participants:

45 term-born, 42 very preterm and 16 extremely preterm infants.

Outcomes:

Cortisol stress response to vaccination (postvaccination minus prevaccination cortisol concentrations), diurnal slope (log-transformed morning minus log-transformed evening cortisol values) …

Determinants Of Blood Acylcarnitine Concentrations In Healthy Individuals Of The European Prospective Investigation Into Cancer And Nutrition, Roland Wedekind, Joseph A. Rothwell, Vivian Viallon, Pekka Keski-Rahkonen, Julie A. Schmidt, Veronique Chajes, Vna Katzke, Theron Johnson, Maria Santucci De Magistris, Vittorio Krogh, Pilar Amiano, Carlotta Sacerdote, Daniel Redondo-Sánchez, José María Huerta, Anne Tjønneland, Pratik Pokharel, Paula Jakszyn, Rosario Tumino, Eva Ardanaz, Torkjel M. Sandanger, Anna Winkvist, Johan Hultdin, Matthias B. Schulze, Elisabete Weiderpass, Marc J. Gunter, Inge Huybrechts

Research outputs 2022 to 2026

Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty …

Progressive Resistance Training For Concomitant Increases In Muscle Strength And Bone Mineral Density In Older Adults: A Systematic Review And Meta-Analysis, Steven J. O’Bryan, Catherine Giuliano, Mary N. Woessner, Sara Vogrin, Cassandra Smith, Gustavo Duque, Itamar Levinger

Research outputs 2022 to 2026

Background:

Older adults experience considerable muscle and bone loss that are closely interconnected. The efficacy of progressive resistance training programs to concurrently reverse/slow the age-related decline in muscle strength and bone mineral density (BMD) in older adults remains unclear.

Objectives:

We aimed to quantify concomitant changes in lower-body muscle strength and BMD in older adults following a progressive resistance training program and to determine how these changes are influenced by mode (resistance only vs. combined resistance and weight-bearing exercises), frequency, volume, load, and program length.

Methods:

MEDLINE/PubMed and Embase databases were searched for articles published in English before 1 June, …

Appropriateness Of Indirect Markers Of Muscle Damage Following Lower Limbs Eccentric-Biased Exercises: A Systematic Review With Meta-Analysis, Emeric Chalchat, Anne Fleur Gaston, Keyne Charlot, Luis Peñailillo, Omar Valdés, Pierre Emmanuel Tardo-Dino, Kazunori Nosaka, Vincent Martin, Sebastian Garcia-Vicencio, Julien Siracusa

Research outputs 2022 to 2026

Purpose The aim of this review was to (1) characterize the time-course of markers of exercise-induced muscle damage (EIMD) based on the level of maximal voluntary contraction torque loss at 24-48h post-exercise (MVCloss24-48h), (2) identify factors (e.g., exercise and population characteristics) affecting the level of MVCloss24-48h, and (3) evaluate the appropriateness of EIMD markers as indicators of MVCloss24-48h. Methods Magnitude of change of each EIMD markers was normalized using the standardized mean differences method to compare the results from different studies. Time-course of EIMD markers were characterized according to three levels of MVCloss24-48h based on a clustering analysis of the …

Location-Specific Cutaneous Electrical Stimulation Of The Footsole Modulates Corticospinal Excitability To The Plantarflexors And Dorsiflexors During Standing, Gagan Gill, Davis A. Forman, Joanna E. Reeves, Janet L. Taylor, Leah R. Bent

Research outputs 2022 to 2026

Non-noxious electrical stimulation to distinct locations of the foot sole evokes location-specific cutaneous reflex responses in lower limb muscles. These reflexes occur at latencies that may enable them to be mediated via a transcortical pathway. Corticospinal excitability to the plantarflexors and dorsiflexors was measured in 16 participants using motor evoked potentials (MEPs). Spinal excitability was measured in eight of the original participants using cervicomedullary motor evoked potentials (CMEPs). Measurements were collected with and without preceding cutaneous stimulus to either the heel (HEEL) or metatarsal (MET) locations of the foot sole, and evoked potentials were elicited to coincide with the arrival …

Dietary Supplements In People With Metastatic Cancer Who Are Experiencing Malnutrition, Cachexia, Sarcopenia, And Frailty: A Scoping Review, Jolyn Johal, Chad Yixian Han, Ria Joseph, Zachary Munn, Oluwaseyifunmi Andi Agbejule, Fiona Crawford‐Williams, Matthew P. Wallen, Raymond J. Chan, Nicolas H. Hart

Research outputs 2022 to 2026

Cancer‐associated malnutrition, or cachexia, stemming from cancer or its treatments, is particularly prevalent in metastatic cancers, and is often interrelated with sarcopenia and frailty. Evidence suggests that dietary supplements play a role in managing these conditions. As metastatic cancer cells are associated with notable genomic and phenotypic alterations, response to dietary supplements may differ between metastatic and non‐metastatic cancers. However, research in this area is lacking. This scoping review aims to identify the dietary supplements that have been studied in patients with metastatic cancers and malnutrition‐related conditions, along with their proposed effects, mechanisms, outcome measures, and tools used. A systematic …

Offspring Conceived Through Art Have Normal Thyroid Function In Adolescence And As Young Adults, L. A. Wijs, D. A. Doherty, J. A. Keelan, V. Panicker, P. Burton, J. L. Yovich, R. J. Hart

Research outputs 2022 to 2026

STUDY QUESTION: Are there differences in thyroid function between adolescents and young adults conceived with and without ART? SUMMARY ANSWER: This study demonstrated no evidence of clinically relevant differences in thyroid function between adolescents and young adults conceived with and without ART. WHAT IS KNOWN ALREADY: Studies to date have reported an increase in subclinical hypothyroidism in offspring conceived after ART. It has been suggested that the increase in maternal estrogen (E2) after fresh embryo transfers could affect thyroid function of the offspring. Suboptimal thyroid function at a young age can cause irreversible damage to the central nervous system, which …

Prospective Dietary Polyunsaturated Fatty Acid Intake Is Associated With Trajectories Of Fatty Liver Disease: An 8 Year Follow-Up Study From Adolescence To Young Adulthood, Fuzhen Wan, Feng Pan, Oyekoya Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Therese A. O’Sullivan, John K. Olynyk, Wendy H. Oddy

Research outputs 2022 to 2026

Background and aim:

Dietary fat intake has long been associated with fatty liver. Our study aimed to determine the effect of dietary fats on longitudinal fatty liver index (FLI) trajectories from adolescence to young adulthood.

Methods:

Nine hundred eighty-five participants in the Raine Study, Perth, Western Australia, Australia, had cross-sectional assessments at ages 14, 17, 20 and 22 years, during which anthropometric measurements and blood tests were obtained. FLI trajectories were derived from the longitudinal FLI results. Dietary fat intake was measured with a semi-quantitative food frequency questionnaire at 14 years and log multinominal regression analyses were used to estimate …

The Nutritional Quality Of Kids’ Menus From Cafés And Restaurants: An Australian Cross‐Sectional Study, Gina S. A. Trapp, Claire E. Pulker, Miriam Hurworth, Kristy K. Law, Sally Brinkman, Christina M. Pollard, Amelia J. Harray, Ros Sambell, Joelie Mandzufas, Stephanie Anzman‐Frasca, Siobhan Hickling

Research outputs 2022 to 2026

Australian families increasingly rely on eating foods from outside the home, which in-creases intake of energy‐dense nutrient‐poor foods. ‘Kids’ Menus’ are designed to appeal to families and typically lack healthy options. However, the nutritional quality of Kids’ Menus from cafes and full‐service restaurants (as opposed to fast‐food outlets) has not been investigated in Australia. The aim of this study was to evaluate the nutritional quality of Kids’ Menus in restaurants and cafés in metropolitan Perth, Western Australia. All 787 cafes and restaurants located within the East Metropolitan Health Service area were contacted and 33% had a separate Kids’ Menu. The …

“You Never Exhale Fully Because You're Not Sure What's Next”: Parents' Experiences Of Stress Caring For Children With Chronic Conditions, Stephanie Smith, Mary Tallon, Carrie Clark, Lauren Jones, Evalotte Mörelius

Research outputs 2022 to 2026

Children with chronic conditions are experiencing improved survival worldwide, and it is well-known that their parents are stressed. Yet, despite this knowledge, parents continue to experience stress. Our study explored the lived experience of parental stress when caring for children with various chronic conditions to identify opportunities to potentially reduce stress for these parents. This was an exploratory qualitative study using semi-structured interviews. To ensure appropriate research priorities were addressed, the study was co-designed with consumer and stakeholder involvement. Twenty parents were interviewed. Parents were recruited through a recognized family support organization for children with various care needs in Western …

Effects Of A Multicomponent Resistance-Based Exercise Program With Protein, Vitamin D And Calcium Supplementation On Cognition In Men With Prostate Cancer Treated With Adt: Secondary Analysis Of A 12-Month Randomised Controlled Trial, Niamh Liana Mundell, Patrick J. Owen, Jack Dalla Via, Helen Macpherson, Robin Daly, Patricia M. Livingston, Timo Rantalainen, Stephen Foulkes, Jerremy Millar, Declan G. Murphy, Steve Fraser

Research outputs 2022 to 2026

OBJECTIVES: The aim of this preplanned secondary analysis of a 12-month randomised controlled trial was to investigate the effects of a multicomponent exercise programme combined with daily whey protein, calcium and vitamin D supplementation on cognition in men with prostate cancer treated with androgen deprivation therapy (ADT). DESIGN: 12-month, two-arm, randomised controlled trial. SETTING: University clinical exercise centre. PARTICIPANTS: 70 ADT-treated men were randomised to exercise-training plus supplementation (Ex+ Suppl, n=34) or usual care (control, n=36). INTERVENTION: Men allocated to Ex + Suppl undertook thrice weekly resistance training with weight-bearing exercise training plus daily whey protein (25 g), calcium (1200 …

Effectiveness Of Nurse-Led Volunteer Support And Technology-Driven Pain Assessment In Improving The Outcomes Of Hospitalised Older Adults: Protocol For A Cluster Randomised Controlled Trial, Rosemary Saunders, Kate Crookes, Karla Seaman, Seng Giap Marcus Ang, Caroline Bulsara, Max K. Bulsara, Beverley Ewens, Olivia Gallagher, Renee M. Graham, Karen Gullick, Sue Haydon, Jeff Hughes, Mustafa Atee, Kim Huong Nguyen, Bev O'Connell, Debra Scaini, Christopher Etherton-Beer

Research outputs 2022 to 2026

Introduction:

Hospitalised older adults are prone to functional deterioration, which is more evident in frail older patients and can be further exacerbated by pain. Two interventions that have the potential to prevent progression of frailty and improve patient outcomes in hospitalised older adults but have yet to be subject to clinical trials are nurse-led volunteer support and technology-driven assessment of pain.

Methods and Analysis:

This single-centre, prospective, non-blinded, cluster randomised controlled trial will compare the efficacy of nurse-led volunteer support, technology-driven pain assessment and the combination of the two interventions to usual care for hospitalised older adults. Prior to commencing …

Association Of Plasma Neurofilament Light Chain With Glycaemic Control And Insulin Resistance In Middle-Aged Adults, Rohith N. Thota, Pratishtha Chatterjee, Steve Pedrini, Eugene Hone, Jessica J. A. Ferguson, Manohar L. Garg, Ralph N. Martins

Research outputs 2022 to 2026

Aims: This study aimed to determine the association of plasma neurofilament light (NfL), a marker of neurodegeneration, with diabetes status and glycaemic parameters in people with normal glycaemia (NG), pre-diabetes (PD) and type 2 diabetes (T2D). Methods: Clinical and descriptive data for the diagnostic groups, NG (n=30), PD (n=48) and T2D (n=29), aged between 40 and 75 years were included in this cross-sectional analysis. Plasma NfL levels were analyzed using the ultra-sensitive single-molecule array (Simoa) platform. Results: A positive correlation was evident between plasma NfL and fasting glucose (r = 0.2824; p = 0.0032). Plasma NfL levels were not correlated …

She'll Be ‘Right… But Are They? An Australian Perspective On Women In High Performance Sport Coaching, Alexandra H. Roberts, Anthea Clarke, Caitlin Fox-Harding, Georgia Askew, Clare Macmahon, Sophia Nimphius

Research outputs 2022 to 2026

Participation and media coverage of women in high-performance sport has been steadily increasing in recent years throughout the world. While this increase in interest has led to many young women and girls becoming involved in grassroots sport, there has yet to be a significant change in the number of women in coaching roles, particularly at the high-performance level. This paper synthesizes and summarizes the current challenges facing women sport coaches in Australia, drawing from existing research, media and government reports to understand the barriers for women entering and progressing in these roles. We also present some of the more recent …

Weight Loss For Overweight And Obese Patients With Prostate Cancer: A Study Protocol Of A Randomised Trial Comparing Clinic-Based Versus Telehealth Delivered Exercise And Nutrition Intervention (The Telex Trial), Daniel A. Galvão, Dennis R. Taaffe, Dickon Hayne, Pedro Lopez, Philippa Lyons-Wall, Colin I. Tang, Suzanne K. Chambers, Amanda Devine, Nigel Spry, Emily Jeffery, Christine Kudiarasu, David Joseph, Robert U. Newton

Research outputs 2022 to 2026

Introduction Obese men with prostate cancer have an increased risk of biochemical recurrence, metastatic disease and mortality. For those undergoing androgen deprivation therapy (ADT), substantial increases in fat mass are observed in the first year of treatment. Recently, we showed that a targeted supervised clinic-based exercise and nutrition intervention can result in a substantial reduction in fat mass with muscle mass preserved in ADT-treated patients. However, the intervention needs to be accessible to all patients and not just those who can access a supervised clinic-based programme. The purpose of this study was to evaluate the efficacy of telehealth delivered compared …

The Mosaic Oat Genome Gives Insights Into A Uniquely Healthy Cereal Crop, Nadia Kamal, Nikos Tsardakas Renhuldt, Johan Bentzer, Heidrun Gundlach, Georg Haberer, Angéla Juhász, Thomas Lux, Utpal Bose, Jason A. Tye-Din, Daniel Lang, Nico Van Gessel, Ralf Reski, Yong Bi Fu, Peter Spégel, Alf Ceplitis, Axel Himmelbach, Amanda J. Waters, Wubishet A. Bekele, Michelle L. Colgrave, Mats Hansson, Nils Stein, Klaus F.X. Mayer, Eric N. Jellen, Peter J. Maughan, Nicholas A. Tinker, Martin Mascher, Olof Olsson, Manuel Spannagl, Nick Sirijovski

Research outputs 2022 to 2026

Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x = 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields in Anatolia1,2. Oat has a low carbon footprint, substantial health benefits and the potential to replace animal-based food products. However, the lack of a fully annotated reference genome has hampered efforts to deconvolute its complex evolutionary history and functional gene dynamics. Here we present a high-quality reference genome of A. sativa and close relatives of its diploid (Avena longiglumis, AA, 2n = 14) and tetraploid …

Non-Pharmacological Self-Management Strategies For Chemotherapy-Induced Peripheral Neuropathy In People With Advanced Cancer: A Systematic Review And Meta-Analysis, Megan Crichton, Patsy M. Yates, Oluwaseyifunmi Andi Agbejule, Amy Spooner, Raymond J. Chan, Nicolas H. Hart

Research outputs 2022 to 2026

Non-pharmacological self-management interventions for chemotherapy-induced peripheral neurotherapy (CIPN) are of clinical interest; however, no systematic review has synthesized the evidence for their use in people with advanced cancer. Five databases were searched from inception to February 2022 for randomized controlled trials assessing the effect of non-pharmacological self-management interventions in people with advanced cancer on the incidence and severity of CIPN symptoms and related outcomes compared to any control condition. Data were pooled with metaanalysis. Quality of evidence was appraised using the Revised Cochrane Risk of Bias Tool for Randomized Trials (RoB2), with data synthesized narratively. Grading of Recommendations, Assessment, Development …

Effects Of Upper Body Eccentric Versus Concentric Strength Training And Detraining On Maximal Force, Muscle Activation, Hypertrophy And Serum Hormones In Women, Keijo Häkkinen, Robert U. Newton, Simon Walker, Arja Häkkinen, Sonja Krapi, Rebekka Rekola, Päivi Koponen, William J. Kraemer, G. Gregory Haff, Anthony Blazevich, Kazunori Nosaka, Juha Ahtiainen

Research outputs 2022 to 2026

Effects of eccentric (ECC) versus concentric (CON) strength training of the upper body performed twice a week for 10 weeks followed by detraining for five weeks on maximal force, muscle activation, muscle mass and serum hormone concentrations were investigated in young women (n = 11 and n = 12). One-repetition bench press (1RM), maximal isometric force and surface electromyography (EMG) of triceps brachii (TB), anterior deltoid (AD) and pectoralis major (PM), cross-sectional area (CSA) of TB (Long (LoH) and Lateral Head (LaH)) and thickness of PM, as well as serum concentrations of free testosterone, cortisol, follicle-stimulating hormone, estradiol and sex …

Dietary Nitrate Intake Is Associated With Decreased Incidence Of Open-Angle Glaucoma: The Rotterdam Study, Joëlle E. Vergroesen, Tosca O. E. De Crom, Lauren C. Blekkenhorst, Caroline C. W. Klaver, Trudy Voortman, Wishal D. Ramdas

Research outputs 2022 to 2026

Previous studies suggest that nitric oxide is involved in the regulation of the intraocular pressure (IOP) and in the pathophysiology of open-angle glaucoma (OAG). However, prospective studies investigating the association between dietary nitrate intake, a source of nitric oxide, and incident (i)OAG risk are limited. We aimed to determine the association between dietary nitrate intake and iOAG, and to evaluate the association between dietary nitrate intake and IOP. From 1991 onwards, participants were followed each five years for iOAG in the Rotterdam Study. A total of 173 participants developed iOAG during follow-up. Cases and controls were matched on age (mean …

Telehealth Cancer-Related Fatigue Clinic Model For Cancer Survivors: A Pilot Randomised Controlled Trial Protocol (The T-Crf Trial), Rahul Ladwa, Elizabeth P. Pinkham, Laisa Teleni, Brigid Hanley, Gemma Lock, Jodie Nixon, Oluwaseyifunmi Andi Agbejule, Fiona Crawford-Williams, Lee Jones, Mark B. Pinkham, Jane Turner, Patsy Yates, Steven M. Mcphail, Joanne F. Aitken, Carmen P. Escalante, Nicolas H. Hart, Raymond J. Chan

Research outputs 2022 to 2026

INTRODUCTION: Cancer-related fatigue (CRF) is one of the most common and debilitating adverse effects of cancer and its treatment reported by cancer survivors. Physical activity, psychological interventions and management of concurrent symptoms have been shown to be effective in alleviating CRF. This pilot randomised controlled trial (RCT) will determine the feasibility of a telehealth CRF clinic intervention (T-CRF) to implement evidence-based strategies and assess the impact of the intervention on CRF and other clinical factors in comparison to usual care. METHODS AND ANALYSIS: A parallel-arm (intervention vs usual care) pilot RCT will be conducted at the Princess Alexandra Hospital in …

Evaluation Of The Major Seed Storage Proteins, The Conglutins, Across Genetically Diverse Narrow-Leafed Lupin Varieties, Arineh Tahmasian, Angéla Juhász, James A. Broadbent, Mitchell G. Nye-Wood, Thao T. Le, Michelle L. Colgrave

Research outputs 2022 to 2026

Lupin seeds have an excellent nutritional profile, including a high proportion of protein and dietary fiber. These qualities make lupin seeds an ideal candidate to help meet the growing global demand for complementary sources of protein. Of consequence to this application, there are nutritional and antinutritional properties assigned to the major lupin seed storage proteins—referred to as α-, β-, δ- and γ-conglutins The variation in the abundance of these protein families can impact the nutritional and bioactive properties of different lupin varieties. Hence, exploring the conglutin protein profiles across a diverse range of lupin varieties will yield knowledge that can …

Estropause, Sex Hormones And Metal Homeostasis In The Mouse Brain, Tianbing Liu, Richard L. Bowen, Andrea C. Wilson, Craig S. Atwood

Research outputs 2022 to 2026

Alterations in brain metal ion homeostasis have been reported with aging and are implicated in the pathogenesis of neurodegenerative diseases. To assess whether age-related changes in hypothalamic-pituitary-gonadal (HPG) hormones might be involved in modulating brain metal ion homeostasis, we treated 7.5-month intact, sham-ovariecomized and ovariectomized C57B6SJL mice with vehicle or leuprolide acetate (for 9-months) to differentiate between whether sex steroids or gonadotropins might modulate brain metal ion concentrations. Unlike other aging mammals, there was no increase in plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) concentrations following estropause in mice, suggesting there was sufficient residual production by the follicle depleted …

Plant Protein-Based Nanocomposite Films: A Review On The Used Nanomaterials, Characteristics, And Food Packaging Applications, Shima Jafarzadeh, Mehrdad Forough, Sajed Amjadi, Vahid J. Javan Kouzegaran, Hadi Almasi, Farhad Garavand, Masoumeh Zargar

Research outputs 2022 to 2026

Consumer demands to utilize environmentally friendly packaging have led researchers to develop packaging materials from naturally derived resources. In recent years, plant protein-based films as a replacement for synthetic plastics have attracted the attention of the global food packaging industry due to their biodegradability and unique properties. Biopolymer-based films need a filler to show improved packaging properties. One of the latest strategies introduced to food packaging technology is the production of nanocomposite films which are multiphase materials containing a filler with at least one dimension less than 100 nm. This review provides the recent findings on plant-based protein films as …