Digital Commons Network^™

European Respiratory Society International Congress 2021: Highlights From Best-Abstract Awardees, Sanjay Ramakrishnan, Fabien Beaufils, Jana De Brandt, Kerri Viney, Claire Bradley, Vincent Cottin, G. Maged Hassan, Joana Cruz

Research outputs 2022 to 2026

This article provides an overview of some of the highlights of the @EuroRespSoc Congress 2021 from the perspective of the best-abstract awardees of the ERS Assemblies @EarlyCareerERS @OrphaLung https://bit.ly/3JCjHYS Every year, the European Respiratory Society (ERS) offers grants to recognise the best overall abstracts of the 14 ERS Assemblies submitted for the ERS International Congress, covering all respiratory areas. The authors of the best abstract (i.e. the highest average score of abstract reviewers and only those who have not applied or were not eligible for a sponsored award) were invited to write a short summary about their virtual Congress experience …

Cryptocurrencies, Diversification And The Covid-19 Pandemic, David E. Allen

Research outputs 2022 to 2026

This paper features an analysis of cryptocurrencies and the impact of the COVID-19 pandemic on their effectiveness as a portfolio diversification tool and explores the correlations between the continuously compounded returns on Bitcoin, Ethereum and the S&P500 Index using a variety of parametric and non-parametric techniques. These methods include linear standard metrics such as the application of ordinary least squares regression (OLS) and the Pearson, Spearman and Kendall’s tau measures of association. In addition, non-linear, non-parametric measures such as the Generalised Measure of Correlation (GMC) and non-parametric copula estimates are applied. The results across this range of measures are consistent. …

Evaluation Of Pd-L1 Expression On Circulating Tumour Cells In Small-Cell Lung Cancer, Emmanuel Acheampong, Afaf Abed, Michael Morici, Isaacs Spencer, Aaron B. Beasley, Samantha Bowyer, Du Bois Asante, Chris Lomma, Weitao Lin, Michael Millward, Elin S. Gray

Research outputs 2022 to 2026

Background: Antibodies against the programmed death-1 (PD-1) receptor and its ligand (PD-L1) have been recently approved for small-cell lung cancer (SCLC) treatment. Circulating tumour cells (CTCs) have emerged as an appealing liquid biopsy candidate that could enhance treatment decision-making in systemic therapy for SCLC patients. Several current technologies enrich CTCs using specific surface epitopes, size, rigidity, or dielectric properties. However, they are hampered by the heterogeneity of the enriched cells from blood samples. Methods: We evaluated two CTC enrichment systems: EpCAM conjugated to magnetic beads and a microfluidic device (Parsortix, Angle plc). PD-L1 expression was evaluated on the isolated CTCs. …

Assessing The Causal Effects Of Adipokines On Uric Acid And Gout: A Two-Sample Mendelian Randomization Study, Ruyi Cong, Xiaoyu Zhang, Zihong Song, Shanshan Chen, Guanhua Liu, Yizhi Liu, Xiuyu Pang, Fang Dong, Weijia Xing, Youxin Wang, Xizhu Xu

Research outputs 2022 to 2026

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also …

High Definition Tdcs Effect On Postural Control In Healthy Individuals: Entropy Analysis Of A Crossover Clinical Trial, Diandra B. Favoretto, Eduardo Bergonzoni, Diego Carvalho Nascimento, Francisco Louzada, Tenysson W. Lemos, Rosangela A. Batistela, Renato Moraes, João P. Leite, Brunna P. Rimoli, Dylan J. Edwards, Taiza G.S. Edwards

Research outputs 2022 to 2026

Objective: Converging evidence supporting an effect of transcranial direct current stimulation (tDCS) on postural control and human verticality perception highlights this strategy as promising for post-stroke rehabilitation. We have previously demonstrated polarity-dependent effects of high-definition tDCS (HD-tDCS) on weight-bearing asymmetry. However, there is no investigation regarding the time-course of effects on postural control induced by HD-tDCS protocols. Thus, we performed a nonlinear time series analysis focusing on the entropy of the ground reaction force as a secondary investigation of our randomized, double-blind, placebo-controlled, crossover clinical trial. Materials and Methods: Twenty healthy right-handed young adults received the following conditions (random order, …

Travel Ban Effects On Sars-Cov-2 Transmission Lineages In The Uae As Inferred By Genomic Epidemiology, Andreas Henschel, Samuel F. Feng, Rifat A. Hamoudi, Gihan Daw Elbait, Ernesto Damiani, Fathimathuz Waasia, Guan K. Tay, Bassam H. Mahboub, Maimunah Hemayet Uddin, Juan Acuna, Eman Alefishat, Rabih Halwani, Herbert F. Jelinek, Farah Mustafa, Nawal Alkaabi, Habiba S. Alsafar

Research outputs 2022 to 2026

Global and local whole genome sequencing of SARS-CoV-2 enables the tracing of domestic and international transmissions. We sequenced Viral RNA from 37 sampled Covid-19 patients with RT-PCR-confirmed infections across the UAE and developed time-resolved phylogenies with 69 local and 3,894 global genome sequences. Furthermore, we investigated specific clades associated with the UAE cohort and, their global diversity, introduction events and inferred domestic and international virus transmissions between January and June 2020. The study comprehensively characterized the genomic aspects of the virus and its spread within the UAE and identified that the prevalence shift of the D614G mutation was due to …

The Heterogeneous Impact Of Sectoral Foreign Aid Inflows On Sectoral Growth: Sur Evidence From Selected Sub-Saharan African And Mena Countries, Nadeem Abdulmalik Abdulrahman Aljonaid, Fengming Qin, Zhaoyong Zhang

Research outputs 2022 to 2026

A great deal of the foreign aid–growth literature finds that the net effect of aggregate aid on total growth appears to be insignificant. This study argues that this aid–growth nexus can be better explained by testing the variation responses for each of growth sectors to their corresponding allocated aid inflows. It aims to investigate the heterogeneous effects of sectorally allocated aid inflows on their corresponding growth sectors (industry, agriculture and services) using data from 37 Sub-Saharan African and MENA-recipient developing nations from 1996 to 2017. We constructed two measures; one is the (SAASG) Sectoral-Allocated-Aid-for Sectoral-Growth, which was used as a …

The Role Of Igg N-Galactosylation In Spondyloarthritis, Xiaojia Xu, Lois A. Balmer, Zhixian Chen, Gehendra Mahara, Ling Lin

Research outputs 2022 to 2026

Spondyloarthritis (SpA) is a group of chronic inflammatory arthritic diseases causing inflammatory back pain and stiffness, leading to irreversible damage of joint and spine, seriously affecting the quality of life. However, the exact pathogenesis of SpA is still unknown, although the blockers of tumor necrosis factor (TNF) are a major therapeutic advance. Of interest is the association between SpA and Immunoglobulin G (IgG) N-glycosylation. IgG N-glycosylation is a process of post-translational modification (PTM) that takes part in regulating anti- and pro-inflammatory effects. A relationship between IgG N-glycosylation and the development of inflammatory arthritic diseases exists, in addition …

Immunoanalytic Investigation Of Grain Proteins Antigenic For Celiac Disease Patients In An Einkorn Collection, Zsófia Birinyi, Dalma Réder, Ádám Diós, Ilma R. Korponay-Szabó, Éva Hunyadi-Gulyás, Christakis George Florides, Angéla Juhász, Gyöngyvér Gell

Research outputs 2022 to 2026

Our study focuses on the complex characterization of a wild and cultivated einkorn collection of the Cereal Gene Bank of Agriculture Research Institute in Hungary, using proteomics, immune analytics and bioinformatics analyses. In a serological ELISA pre-screen of 208 different Triticum monococcum L. ssp. monococcum and Triticum monococcum L. ssp. aegilopoides genotypes with celiac disease samples high diversity was observed in the immune response. Based on the immune analytic results, four genotypes with significantly reduced immune reactivity were selected for detailed proteomics characterization. Our results confirm the benefits of high-throughput/large-scale pre-screening and the use of a complex examination platform to …

Dual Leadership In Chinese Schools Challenges Executive Principalships As Best Fit For 21st Century Educational Development, Christine Cunningham, Wei Zhang, Michelle Striepe, David Rhodes

Research outputs 2022 to 2026

This paper examines China's dual leadership model and compares it with the more traditional (western) single leader model. It addresses an important question in educational leadership: whether singular school leadership or a dual leadership is better? It is innovative as it mobilised an international research team to collect data from 115 Chinese school leaders and compare China's dual leadership with faith-based schools in other contexts. Given so much now is written about distributed leadership within and across schools, this paper offers valuable insights, especially for readers interested in the educational leadership practices of a rising global power.

How Do Ethical Consumers Utilize Sharing Economy Platforms As Part Of Their Sustainable Resale Behavior? The Role Of Consumers’ Green Consumption Values, Teck Ming Tan, Hannu Makkonen, Puneet Kaur, Jari Salo

Research outputs 2022 to 2026

Past research has extensively studied the antecedents and consequences of consumers’ green consumption values, as well as the psychological mechanisms that underlie an ethical consumer. Yet a frustrating paradox remains, indicated by the consumers’ intention–behavior gap for their sustainable behavior. To address this gap, the present study focuses on the consumption values that lead to using a sharing economy platform. Our study draws on the theory of consumption values and altruistic–egoistic values, as well as spillover effect psychology, to examine associations between context-specific values, green consumption values, and sustainable resale behavior. By collaborating with a Nordic second-hand peer-to-peer platform brand, …

In Vivo Ps-Oct Needle Probe Scan Of Human Skeletal Muscle, Jeffrey M. Mcbride, Michael J. Hackmann, Sophia Nimphius, Barry Cense

Research outputs 2022 to 2026

Polarization-sensitive optical coherence tomography (PS-OCT) derived birefringence values effectively identify skeletal muscle structural disruption due to muscular dystrophy and exercise-related muscle damage in animal models in ex vivo tissue. The purpose of this investigation was to determine if a PS-OCT needle probe inserted into the leg of a human subject could accurately identify various anatomical structures with implications for use as a diagnostic tool for the determination of skeletal muscle pathology. A healthy middle-aged subject participated in this study. A custom-built PS-OCT system was interfaced with a side-viewing fiber-optic needle probe inserted into the subject's vastus lateralis muscle via a …

Alcohol Consumption And Cardiovascular Outcomes In Patients With Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study, Malik Janjua, Matthew Knuiman, Mark Divitini, Brendan Mcquillan, John K. Olynyk, Gary P. Jeffrey, Leon A. Adams

Research outputs 2022 to 2026

Low-level alcohol consumption is associated with reduced cardiovascular disease (CVD) in the general population. It is unclear whether this association is seen in patients with nonalcoholic fatty liver disease (NAFLD) who have an increased risk of CVD. We examined the association between alcohol consumption and CVD-related outcomes in subjects with NAFLD from a general population cohort. Subjects participating in the 1994-1995 Busselton Health survey underwent clinical and biochemical assessment. NAFLD was identified using the Fatty Liver Index of >60, and alcohol consumption quantified using a validated questionnaire. CVD hospitalizations and death during the ensuing 20 years were ascertained using the …

Development Of 1,2,4-Oxadiazole Antimicrobial Agents To Treat Enteric Pathogens Within The Gastrointestinal Tract, Noel P. Pitcher, Jitendra R. Harjani, Yichao Zhao, Jianwen Jin, Daniel Knight, Lucy Li, Papanin Putsathit, Thomas V. Riley, Glen P. Carter, Jonathan B. Baell

Research outputs 2022 to 2026

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analogue 26a results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels …

A Proposed Governance Model For The Adoption Of Geoparks In Australia, Alan Briggs, David Newsome, Ross Dowling

Research outputs 2022 to 2026

Purpose: Good governance is crucial in establishing and managing geoparks and is a requirement by UNESCO if global status is to be achieved. Australia has three levels of government, government agencies and not for profit organisations that can assist in the reintroduction of geoparks to Australia. This paper examines a range of governance models used by UNESCO Global Geoparks. Design/methodology/approach: This paper explores mechanisms that could be applied in the reintroduction of geoparks into Australia and considers how future geoparks might be managed. The suggested model is based on a review of existing UNESCO Global Geopark governance and their management …

Body Gaze As A Marker Of Sexual Objectification: A New Scale For Pervasive Gaze And Gaze Provocation Behaviors In Heterosexual Women And Men, Ross C. Hollett, Shane L. Rogers, Prudence Florido, Belinda Mosdell

Research outputs 2022 to 2026

Body gaze behavior is assumed to be a key feature of sexual objectification. However, there are few self-report gaze measures available and none capturing behavior which seeks to invite body gaze from others. Across two studies, we used existing self-report instruments and measurement of eye movements to validate a new self-report scale to measure pervasive body gaze behavior and body gaze provocation behavior in heterosexual women and men. In Study 1, participants (N = 1021) completed a survey with newly created items related to pervasive body gaze and body gaze provocation behavior. Participants also completed preexisting measures of body attitudes, …

Clostridioides Difficile Infection And One Health: An Equine Perspective, Natasza M. R. Hain-Saunders, Daniel R. Knight, Mieghan Bruce, Thomas V. Riley

Research outputs 2022 to 2026

Clostridioides (Clostridium) difficile presents a significant health risk to humans and animals. The complexity of the bacterial–host interaction affecting pathogenesis and disease development creates an ongoing challenge for epidemiological studies, control strategies and prevention planning. The recent emergence of human disease caused by strains of C. difficile found in animals adds to mounting evidence that C. difficile infection (CDI) may be a zoonosis. In equine populations, C. difficile is a known cause of diarrhoea and gastrointestinal inflammation, with considerable mortality and morbidity. This has a significant impact on both the well-being of the animal and, in the case of performance …

Developing A Food And Beverage Corporate Sustainability Performance Structure In Indonesia: Enhancing The Leadership Role And Tenet Value From An Ethical Perspective, Tat Dat Bui, Hania Aminah, Ching Hsin Wang, Ming Lang Tseng, Mohammad Iranmanesh, Ming K. Lim

Research outputs 2022 to 2026

The food and beverage industry is the second largest contributor to Indonesia’s economy; however, most industry firms significantly, and negatively, impact ecological and economic performance, and corporate sustainability performance is considered an area that can be significantly improved. This study aims to measure the causal interrelationships among the hierarchical attributes, as well as the decisive attributes that force successful corporate sustainability. Further, there are also other factors that have a negative impact, such as poor social justice and firms’ responsibilities and identities. Hence, emphasizing the ethics role to ensure a better sustainable performance in addition to focusing on the traditional …

Electro‐Driven Materials And Processes For Lithium Recovery—A Review, Anna Siekierka, Marek Bryjak, Amir Razmjou, Wojciech Kujawski, Aleksandar N. Nikoloski, Ludovic F. Dumée

Research outputs 2022 to 2026

The mass production of lithium‐ion batteries and lithium‐rich e‐products that are required for electric vehicles, energy storage devices, and cloud‐connected electronics is driving an unprecedented demand for lithium resources. Current lithium production technologies, in which extraction and purification are typically achieved by hydrometallurgical routes, possess strong environmental impact but are also energy‐intensive and require extensive operational capabilities. The emergence of selective membrane materials and associated electro‐processes offers an avenue to reduce these energy and cost penalties and create more sustainable lithium production approaches. In this review, lithium recovery technologies are discussed considering the origin of the lithium, which can be …

Students’ Engagement In Education As Sustainability: Implementing An Ethical Dilemma-Steam Teaching Model In Chemistry Learning, Yuli Rahmawati, Elisabeth Taylor, Peter Charles Taylor, Achmad Ridwan, Alin Mardiah

Research outputs 2022 to 2026

This paper reports the results of a study on the implementation of the Ethical Dilemma STEAM Teaching Model in secondary schools in Jakarta, Indonesia. This interdisciplinary curriculum approach employed ‘ethical dilemma story pedagogy’ in a STEAM education project designed to engage students in values-based chemistry learning. Drawing on the arts, specially written ethical dilemma stories posing real-world environmental problems engaged students in exploring their value systems. Students reflected on the pros and cons of ethical dilemmas related to the everyday use of artificial fertilizers, disposal of used cooking oil and detergent waste, and environmental pollution caused by plastic waste. The …

Simultaneous Strength-Ductility Enhancement In As-Cast Ti6al4v Alloy By Trace Ce, K. M. Li, Y. J. Liu, X. C. Liu, X. Wu, S. F. Zhou, Laichang Zhang, W. Li, W. C. Zhang

Research outputs 2022 to 2026

Impurity elements always play a major role in hindering mechanical property improvement in Ti6Al4V, and specifically most of them e.g. O, P, Cl, and S dissolved in the matrix deteriorate the mechanical properties of Ti6Al4V. This work presents a strategy of enhancing the mechanical performance of as-cast Ti6Al4V alloy by adding a small amount of rare earth (i.e. 0.1 wt% Ce), where deleterious elements could be absorbed from the crystalline lattice during solidification process, forming uniformly distributed Ce-rich oxides or precipitates with ∼200 nm in size. The Ce-rich precipitates in turn refine the beta phase lamellae by introducing more nucleation …

Quantitative Analysis Of Methodological And Environmental Influences On Survival Of Planted Mangroves In Restoration And Afforestation, Daniel Gorman, Mathew A. Vanderklift, Anna Lafratta

Research outputs 2022 to 2026

Mangrove planting has been employed for decades to achieve aims associated with restoration and afforestation. Often, survival of planted mangroves is low. Improving survival might be aided by augmenting the understanding of which planting methods and environmental variables most influence plant survival across a range of contexts. The aim of this study was to provide a global synthesis of the influence of planting methods and background environment on mangrove survival. This was achieved through a global meta-analysis, which compiled published survival rates for the period 1979–2021 and analyzed the influence of decisions about minimum spacing and which life stage to …

Plant Protein-Based Food Packaging Films; Recent Advances In Fabrication, Characterization, And Applications, Milad Hadidi, Shima Jafarzadeh, Mehrdad Forough, Farhad Garavand, Saeid Alizadeh, Ali Salehabadi, Amin Mousavi Khaneghah, Seid Mahdi Jafari

Research outputs 2022 to 2026

Background: Plant-based proteins as an alternative to synthetic polymers have attracted the interest of the global packaging industry in the last decade due to their biodegradability, sustainability, environmental, and beneficial health claims.

Scope and approach: This review covers the recent developments in biodegradable packaging such as edible films/coatings and innovative packaging materials based on plant protein sources. The importance, sources, and techno-functional properties of plant-derived proteins for food packaging are discussed. The impact of different additives on the functionality of plant protein-based biodegradable materials is also investigated. In addition, plant protein-based packaging characteristics and their application in food are also …

Genetic Overlap Analysis Of Endometriosis And Asthma Identifies Shared Loci Implicating Sex Hormones And Thyroid Signalling Pathways, Emmanuel O. Adewuyi, D. Mehta, D. R. Nyholt, International Endogene Consortium (Iec), 23andme Research Team

Research outputs 2022 to 2026

Study question: Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships?

Summary answer: Our results confirm a significant but non-causal association of endometriosis with asthma implicating shared genetic susceptibility and biological pathways in the mechanisms of the disorders, and potentially, their co-occurrence.

What is known already: Some observational studies have reported a pattern of co-occurring relationship between endometriosis and asthma; however, there is conflicting evidence and the aetiology, as well as the underlying mechanisms of the relationship, remain unclear.

Study design, size, duration: We applied multiple statistical genetic …

Development And Validation Of An Astronomy Self-Efficacy Instrument For Understanding And Doing, Rachel Freed, David Mckinnon, Michael Fitzgerald, Christina M. Norris

Research outputs 2022 to 2026

This paper presents a new astronomy self-efficacy instrument, composed of two factors; one relating to learning astronomy content, which we call astronomy personal self-efficacy, and the other relating to the use of astronomical instrumentation, specifically the use of remote robotic telescopes for data collection. The latter is referred to as the astronomy instrumental self-efficacy factor. The instrument has been tested for reliability and construct validity. Reliability testing showed that factor 1 had a Cronbach's α of 0.901 and factor 2 had a Cronbach's α of 0.937. Construct validity was established by computing one-way analyses of variances, with the p value …

Uncertainties In The Projected Patterns Of Wave-Driven Longshore Sediment Transport Along A Non-Straight Coastline, Amin Reza Zarifsanayei, José A. A. Antolínez, Amir Etemad-Shahidi, Nick Cartwright, Darrell Strauss, Gil Lemos

Research outputs 2022 to 2026

This study quantifies the uncertainties in the projected changes in potential longshore sediment transport (LST) rates along a non-straight coastline. Four main sources of uncertainty, including the choice of emission scenarios, Global Circulation Model-driven offshore wave datasets (GCM-Ws), LST models, and their non-linear interactions were addressed through two ensemble modelling frameworks. The first ensemble consisted of the offshore wave forcing conditions without any bias correction (i.e., wave parameters extracted from eight datasets of GCM-Ws for baseline period 1979–2005, and future period 2081–2100 under two emission scenarios), a hybrid wave transformation method, and eight LST models (i.e., four bulk formulae, four …

A Mild Causal Relationship Between Tea Consumption And Obesity In General Population: A Two-Sample Mendelian Randomization Study, Cancan Li, Mingyun Niu, Zheng Guo, Pengcheng Liu, Yulu Zheng, Di Liu, Song Yang, Wei Wang, Yuanmin Li, Haifeng Hou

Research outputs 2022 to 2026

Evidence from observational studies for the effect of tea consumption on obesity is inconclusive. This study aimed to verify the causal association between tea consumption and obesity through a two-sample Mendelian randomization (MR) analysis in general population-based datasets. The genetic instruments, single nucleotide polymorphisms (SNPs) associated with tea consumption habits, were obtained from genome-wide association studies (GWAS): UK Biobank, Nurses’ Health Study, Health Professionals Follow-up Study, and Women’s Genome Health Study. The effect of the genetic instruments on obesity was analyzed using the UK Biobank dataset (among ∼500,000 participants). The causal relationship between tea consumption and obesity was analyzed by …

Editorial: The Use Of Post-Exercise Cooling As A Recovery Strategy: Unraveling The Controversies, Mohammed Ihsan, Chris R. Abbiss, Robert Allan

Research outputs 2022 to 2026

Post-exercise cooling is a popular recovery strategy utilized by athletes, and of interest to many research groups. Significant body of research have examined the effects of post-exercise cooling on outcomes such as physical performance, regulation of inflammatory biomarkers, and psychophysical indices related to perceived fatigue, recovery and wellbeing. ...

Mtor Inhibitors Induce Erythropoietin Resistance In Renal Transplant Recipients, Reece Jefferies, Harish Puttagunta, Anoushka Krishnan, Ashley Irish, Ramyasuda Swaminathan, John K. Olynyk

Research outputs 2022 to 2026

Aim: To elucidate the role of mTOR inhibitors on iron, hepcidin and erythropoietin-mediated regulation of hemopoiesis in stable renal transplant recipients (RTR). Background: Impaired hemopoiesis is common following renal transplantation managed using mTOR inhibitors. The mechanisms responsible are uncertain but include direct effects on iron, hepcidin or erythropoietin-mediated hemopoiesis. Methods: We conducted a single center prospective case-control study of 26 adult RTR with stable allograft function. RTR received stable mTOR dosing (cases, 11/26 [42%]) or stable tacrolimus dosing (controls, 15/26 [58%]). Baseline demographics, full blood count, renal function, iron studies, hepcidin-25, Interleukin-6 (IL-6) and erythropoietin (EPO) levels were determined. Results: …

Forecasting Neuromuscular Recovery After Anterior Cruciate Ligament Injury: Athlete Recovery Profiles With Generalized Additive Modeling, Matthew J. Jordan, Nathaniel Morris, Jeremiah Barnert, Drew Lawson, Isabel Aldrich Witt, Walter H Herzog

Research outputs 2022 to 2026

A retrospective analysis of longitudinally collected athlete monitoring data wasconducted to generate a model of neuromuscular recovery after anterior cruciateligament (ACL) injury and reconstruction (ACLR). Neuromuscular testing data in-cluding countermovement jump (CMJ) force‐time asymmetries and knee extensorstrength (maximum voluntary contractionext) asymmetries (between‐limb asymmetryindex—AI) were obtained from athletes with ACLR using semitendinosus (ST) au-tograft (n= 29; AI measurements: n= 494), bone patellar tendon bone autograft(n= 5; AI measurements:n= 88) and noninjured controls (n= 178; AI measurements:n= 3188). Explosive strength measured as the rate of torque development was alsocalculated. CMJ force‐time asymmetries were measured over discrete movementphases (eccentric deceleration phase, concentric phase). …