Digital Commons Network^™

Exploring The Associations Between Dietary Nitrate And Nitrite Intake And Markers Of Self-Reported Periodontal Disease In The Uk Biobank Cohort, Shatha S. Alhulaefi, Anthony Watson, Kirsten Brandt, Sheena E. Ramsay, Nicholas S. Jakubovics, Alex Griffiths, Jamie Matu, Mario Siervo, Benjamin H, Parmenter, Liezhou Zhong, Jonathan Hodgson, Catherine P. Bondonno, Nicola P. Bondonno, Oliver M. Shannon

Research outputs 2022 to 2026

Purpose: Periodontal disease, an inflammatory condition affecting the tissue surrounding the teeth, has been associated with various systemic health issues. Dietary nitrate and nitrite are found in a range of plant and animal foods and, depending upon source, have been linked with both positive and negative health effects, including improved oral health with plant sources. This study aimed to investigate the associations between source-dependent (plant- and animal-sourced) nitrate and nitrite intake and odds of periodontal disease. Methods: We explored cross-sectional and longitudinal associations between tertiles of source-dependent nitrate and nitrite intake and the odds of periodontal disease using multivariable logistic …

Genai-Assisted Podcasts To Support Nursing Students’ Research Literacy And Evidence-Based Practice: A Feasibility Study, Jennifer Hamilton, Lesley Barr, Martina Costello, Lukman Thalib, Martin Jones

Research outputs 2022 to 2026

Background: Nursing students often report difficulty understanding and applying research evidence, limiting evidence-based practice capability. Podcasts are an accessible method for research dissemination, and generative artificial intelligence (GenAI) may offer a scalable approach to developing research-focused podcasts within curricula. Aims: To assess the feasibility of integrating GenAI-assisted research podcasts into nursing curricula as supplementary learning resources. A secondary objective examined associations in students’ self-reported competencies. Methods: A nonrandomised pre-post study was conducted in two entry-to-practice nursing programs at one Australian university. Episodes were released weekly as additional resources. Students completed the Student Evidence-Based Practice Questionnaire at semester commencement and completion. …

Key Success Factors In Aviation–Start-Up Collaboration: A Framework For Innovation And Value Creation, Bruno Pereira, Gui Lohmann, Luke Houghton, Adela Mcmurray, Mauro Caetano

Research outputs 2022 to 2026

This study addresses how the aviation sector can create value by fostering innovation in collaboration with start-ups. A novel ‘Key-Success Factors in Aviation-Start-up Collaboration Framework’ is proposed to explain the innovation process, identify key success factors, and generate valuable insights into the aviation sector and start-up partnerships. Drawing on 31 of 80 consolidated key success factors selected from the literature and validated through ten interviews with managers of aviation innovation programs and start-up founders, the proposed framework is structured into three dimensions: (i) antecedents, (ii) governance, support, and development, and (iii) innovation and value creation, and 13 related categories. The …

Plant-Based Diets, Ultra-Processed Foods, And Risks Of Mortality And Major Chronic Diseases: A Prospective Cohort Study, Alysha S. Thompson, Amy Jennings, Nicola P. Bondonno, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Background: Higher-quality plant-based diets (PBDs) are associated with lower risks of mortality and chronic disease, but whether ultra-processed food (UPF) content affects these associations remains unclear. We examined whether UPF content influences the relationship between plant-based dietary patterns and risks of mortality and major chronic diseases, accounting for nutrient quality. Methods: This prospective cohort study included 124,836 UK Biobank participants aged 40–70 years (recruited 2006–2010). Dietary intake was assessed using the Oxford WebQ 24-h recall. Four modified Plant-Based Diet Indices (PDIs) were derived to distinguish healthy (hPDI) and unhealthy (uPDI) patterns with high- and low-UPF content, using the Nova classification …

Self-Managed Non-Pharmacological Interventions For Post-Treatment Upper Limb Dysfunction Rehabilition Among Breast Cancer Survivors: A Systematic Review, Jinqiu Li, Jing Yu (Benjamin) Tan, Tao Wang, Haiying Wang, Mengyuan Li, Sita Sharma, Linda Deravin, Daniel Terry

Research outputs 2022 to 2026

Purpose: This study aims to identify commonly utilised self-managed non-pharmacological interventions for managing post-treatment ULD among breast cancer survivors, evaluate their effectiveness and safety, and identify the research gaps for future studies. Methods: A systematic review was conducted, and eight English databases (PubMed, Cochrane Library, Embase, CINAHL, Web of Science, Scopus, PsycINFO, and ProQuest) were searched from their inception to 30 September 2025. Google and ResearchGate were also searched to identify any additional eligible studies. Narrative synthesis was used for data analysis. Risk of Bias version 2 was used to assess the quality of the included studies. Results: 5972 studies …

Source-Specific Nitrate And Nitrite Intake And Bladder Cancer: Findings From The Danish Diet, Cancer And Health Cohort, Dorit W. Erichsen, Cecilie Kyrø, Jörg Schullehner, Susanne Rosthøj, Catherine P. Bondonno, Liezhou Zhong, Ole Raaschou-Nielsen, Pratik Pokharel, Torben Sigsgaard, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Christina Dahl, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Anne Tjønneland, Nicola P. Bondonno

Research outputs 2022 to 2026

Introduction Nitrate and nitrite, present in ground and drinking water, as well as foods, may contribute to bladder cancer through the formation of carcinogenic N -nitrosamines. However, risk likely depends on both the source and endogenous nitrosating factors. Methods Among participants of the Danish Diet, Cancer, and Health Cohort (N = 54,610) with no history of cancer, source-specific nitrate and nitrite intakes (drinking water, plant sources, naturally occurring animal sources, and additive-permitted meat sources) were estimated from national water monitoring data and food frequency questionnaires using food databases. Bladder cancer cases were ascertained through the Danish Cancer Registry. Multivariable-adjusted Cox …

The Ilese Project: Building An Evidentiary Database About Students' Use Of Learning Environments, W. Imms, J. E. Morris, K. Day, C. Bradbeer, L. Lockhart-Barker, C. Campbell

Research outputs 2022 to 2026

This paper presents the progress of a unique study of significant scope. The industry-funded innovative Learning Environments and Student Experience (ILESE) study asked two questions: In what ways has more than two decades of learning spaces research culminated in readily used evidence that meets the needs of those involved in providing innovative education infrastructure? Second, based on perceived strengths and gaps, how do we design research to address identified gaps? This paper reports on the findings to these questions. It draws on the results of a large-scale Scoping Study that sought perspectives from experts equally distributed across (1) industries providing …

Transplantation And Mortality As Competing Outcomes Among Patients On Dialysis With Newly Diagnosed Cancer: A Longitudinal Cohort Study, Ryan Gately, Eric A. Engels, Dharshana Sabanayagam, Armando Teixeira-Pinto, Scott Campbell, Carmel Hawley, Wai Lim, Germaine Wong

Research outputs 2022 to 2026

Rationale & Objective: A cancer diagnosis is associated with complex risks for patients that may influence survival and access to transplantation. This study characterized the probability and timing of cancer-related death, noncancer death, and transplantation among patients with an incident cancer diagnosis after dialysis initiation. Study Design: Longitudinal cohort study. Setting & Participants: In Australia and New Zealand, 2000-2021, 3,052 patients receiving dialysis, identified via the Australia and New Zealand Dialysis and Transplant Registry, with cancer diagnosed after they had started dialysis. Exposure: Cancer, categorized by type and stage. Outcome: Transplantation as well as cancer-related death and noncancer death for …

Updating The Prisma Reporting Guideline For Scoping Reviews: A Scoping Review, Andrea C. Tricco, Emily Robinson, Sharon E. Straus, Heather Colquhoun, Christina M. Godfrey, David Moher, Zachary Munn, Danielle Pollock, Sherrie Logan, Ellen B.M. Elsman, Sabira Hasanoff, Yonda Lai, James Mcmahon, Jasmeen Dourka, Dipika Neupane, Hanan Khalil, Micah D.J. Peters, Lyndsay Alexander, Romy M. Jia, Ashrita Saran, Catrin Evans, Dawid Pieper

Research outputs 2022 to 2026

Background and Objectives The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) extension for scoping reviews (ScRs) (PRISMA-ScR) was published in 2018 to provide reporting guidance. A substantial increase in published ScRs in recent years coupled with the omission or lack of engagement of interest-holders, including patients and public partners, as research partners throughout its development necessitate updating PRISMA-ScR. Important methodological advancements have emerged since PRISMA-ScR 2018, including automation and data extraction, which need to be incorporated into this update and reflected in new reporting items. Aligned with PRISMA 2020, this ScR underpins the update by identifying potential new …

An Open-Source Evaluation Framework For Risc-V Co-Design-Based Decimal Arithmetic, Riaz Ul Haque Mian, Michiko Inoue

Research outputs 2022 to 2026

Hardware–software co-design is a balanced strategy for computationally intensive algorithms such as decimal computing. It can provide several Pareto points for the development of embedded systems in terms of hardware cost and performance. In this study, we propose an efficient and accurate evaluation framework for decimal computing. The framework was designed and developed for hardware–software co-design decimal arithmetic using the RISC-V ecosystem. New binary and decimal-oriented instructions supported by an accelerator were developed. The framework can perform cycle-accurate analysis for performance and assess hardware overhead for co-design-based decimal arithmetic. Unlike previous studies that focused primarily on implementing and evaluating individual …

Attenuation Of Redox Interference In Ruo2 Ph Sensor Using A Ta2o5/Nafion Multilayer Architecture, Wade Lonsdale, Magdalena Wajrak, Md Mahamudul Hassan, James Jin Kang

Research outputs 2022 to 2026

Despite the growing preference for solid-state pH sensors due to their advantages over glass pH electrodes, their practical application is still limited by challenges, particularly in metal-oxide based systems. The main issue is their susceptibility to redox-active species such as dissolved oxygen, ascorbic acid, sulfides, and transition-metal ions. In this work, the effects of representative redox interferents, with particular emphasis on ascorbic acid, together with dissolved oxygen and potassium permanganate, were investigated and mitigated through the application of Ta2O5/Nafion overlayers. The solid-state metal-oxide pH-sensitive electrodes were fabricated with laser micro-etching of radio-frequency (RF) sputtered RuO2 thin films deposited on ceramic …

Ephemeral To Empowered? International Comparison Of Women’S Participation In Web Series Production, 2012–2019, Nicola Evans, Marion Mccutcheon, Emilia King, Joel Bassaget, Steinar Ellingsen

Research outputs 2022 to 2026

Women are significantly underrepresented in above-the-line roles in film and television, but anecdotal evidence suggests they are gravitating to web series. To explore this, the authors built the largest known international archive of web series released during 2012–2019 and analysed women’s participation. In the top five web series producing countries in the West, women achieved or approached parity with men in producing, directing and writing, but not cinematography. Do achievements in low-budget, transitory media count for anything? Drawing on ephemeral media scholarship, we discuss the potential of such forms to disturb entrenched patterns of gender discrimination in screen industries worldwide.

Estimation Of Persistent Inward Currents Contribution To Inspiratory Motoneuron Firing In Humans, Ricardo N.O. Mesquita, Simon C. Gandevia, Janet L. Taylor, Anna L. Hudson, Jane E. Butler

Research outputs 2022 to 2026

Persistent inward currents (PICs) are known to prolong firing of limb-muscle motoneurons. Although there is immunohistochemical evidence of PIC channels in respiratory motoneurons, it is unknown whether PICs contribute to their firing prolongation. Intramuscular electromyographic signals were recorded from human inspiratory muscles to identify motor unit (MU) activity. Diaphragm MUs were identified during quiet breathing (n = 7; one female) and MUs from the 1st, 3rd, and 5th parasternal intercostal muscles during quiet (no lung volume feedback) and voluntary (triangular-shaped lung volume feedback) breathing (n = 5 males). PIC contribution to firing prolongation was estimated via quantification of firing hysteresis …

Evaluating Echo2 Biochar As Sustainable Bitumen Binder Modifier In Road Pavements: High-Temperature Performance Characterisation, Adeel Iqbal, Nuha S. Mashaan, Themelina Paraskeva, Mohamed A. Shahin

Research outputs 2022 to 2026

The incorporation of bio-derived modifiers in bitumen binders presents a practical pathway toward sustainable, carbon-sequestering road pavement infrastructure. This study evaluates commercially produced ECHO2 softwood biochar as a modifier for Australian viscosity-graded C170 bitumen, combining microstructural, thermal, physical, and rheological characterization to assess its suitability as a high-temperature reinforcing modifier. In this study, biochar was incorporated at 3%, 6%, 9%, and 12% by weight, utilizing particles smaller than 75 µm to maximize interfacial interaction. Characterization via SEM-EDS, XRD, and TGA revealed a highly stable, carbon-rich, amorphous material with a rough, porous morphology, favourable for physical interlocking with the bitumen matrix. …

Exploring Traditional Breast Cancer Risk Genes Among Aboriginal And Torres Strait Islander Women, Katie Meehan, Leanne Pilkington, Azim Khan, Nicholas Pachter, Lisa Spalding, Ayeisha Milligan Armstrong, Cameron Redfern, Andrew Redfern

Research outputs 2022 to 2026

Background: Germline pathogenic variants in BRCA1/2 increase breast and ovarian cancer risk, but their prevalence in Aboriginal and Torres Strait Islander (herein referred to as Aboriginal) families has never been studied. Consequently, their contribution to breast cancer in this population is unknown.

Methods: This retrospective cohort study included 259 Aboriginal women and 789 age- and remoteness-matched non-Aboriginal women diagnosed with breast cancer (2001–2016). We assessed family history, genetic service referral and testing rates, and pathogenic variant rates in the context of testing access.

Results: Family history data were available for more Aboriginal than non-Aboriginal cases (46% vs. 34%, p < 0.001), with no difference in reported first-degree relatives with breast (22.5% vs. 22.4%, p = 0.98) or ovarian cancer (4.2% vs. 2.2%, p = 0.29). Similar proportions were referred to genetic services for testing eligibility (5.4% vs. 7.2%, p = 0.392). Of those referred, similar proportions were offered testing (86% vs. 81%, p = 0.66). Across the full cohort, BRCA1/2 pathogenic variants were detected in 0.77% of Aboriginal versus 2.4% of non-Aboriginal women (p = 0.127); any pathogenic gene variant was detected in 0.77% versus 3.0% (p = 0.039).

Conclusions: …

Gut Microbiome Changes In Preclinical Alzheimer’S Disease, D. M. Sithara Dissanayaka, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Thilini N. Jayasinghe, Vincent Ho, Vijay Jayasena, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that develops many years before clinical symptoms appear. The biological changes involved in the earliest stages remain poorly understood, particularly during the preclinical stage. Our previous work has identified gradual gut microbial and metabolic changes during this stage, suggesting these may represent early biological shifts that precede disease progression. Recent studies suggest that the gut microbiome may contribute to early AD processes through its effects on immune regulation, metabolism, and gut–brain communication. Changes in gut microbial composition, including reduced levels of short-chain fatty acid (SCFA)-producing bacteria, such as Faecalibacterium, Roseburia, and Eubacterium, …

Codesign And Implementation Of A Tai Chi Intervention For Managing The Fatigue, Sleep Disturbance And Depression Symptom Cluster In Breast Cancer Survivors In Regional Australia: A Feasibility Study Protocol, Suellen Skinner, Wai Hang Kwok, Jing Yu Benjamin Tan, Tao Wang, Daniel Bressington, Liqun Yao, Brona Nic Giolla Easpaig

Research outputs 2022 to 2026

Introduction: Breast cancer survivors (BCS) often experience side effects such as the fatigue, sleep disturbance and depression symptom cluster (FSDSC). Previous studies have demonstrated the potential efficacy of Tai Chi (TC) for improving FSDSC in BCS in a hospital setting in China. This study will explore the feasibility, acceptability and preliminary effects of the Easy 8 Form TC protocol as an adjuvant therapy in BC survivorship care, adapted to a regional Australian community setting.

Methods and analysis: The purpose of the present study is to provide a codesigned TC protocol. This multimethod study comprises a codesign study, followed by a …

Limited Australian Clinical Guidelines For Pain Assessment In Hospitalized Older Adults With Cognitive Impairment: Implications For Safe And Quality Care, Rosemary Saunders, Kaoru Nosaka, Seng Giap Marcus Ang, Natasya Raja Azlan, Aaron Alejandro, Rohini Sharma Bhardwaj, Olivia Gallagher, Irene Ngune, Amineh Rashidi, Yan Hui Celestine Wee, Nilufeur Mckay

Research outputs 2022 to 2026

Introduction – Pain assessment remains challenging in healthcare settings in patients who are unable to self-report their pain. More than 50% of individuals with dementia and other forms of cognitive impairment (CI) experience pain daily. However, pain is frequently overlooked and inadequately assessed by healthcare professionals due to their lack of knowledge and guidelines to inform pain assessment. Pain is also a leading cause of hospital presentation and inappropriate pain assessment can impact on pain management and compromise safe and quality care. Evidence-based guidelines that inform appropriate pain assessment and management are therefore essential. This scoping review aimed to explore …

Community Energy Storage: A Framework For Enhanced Energy Trading And Cost Efficiency, Bassam Al-Hanahi, Aziz

Research outputs 2022 to 2026

The integration of renewable energy sources (RES) into modern electricity grids introduces substantial challenges, primarily due to their inherent variability and the critical need for real-time supply-demand balancing. Community Battery Storage system (CBSS) has emerged as an effective strategy to address these challenges, enhancing grid stability and providing localized economic benefits through optimized energy storage and management. This paper presents a novel energy trading framework that prioritizes community welfare by balancing the reduction of user energy costs with CBSS revenue generation. The proposed model employs a multi-objective optimization approach, utilizing the epsilon-constraint method to strike an optimal balance between minimizing …

Techno-Economic And Environmental Analysis Of A Hybrid Renewable Energy System With V2h Support For Remote Australian Communities, Tushar Kanti Roy, K. Das, Md Apel Mahmud

Research outputs 2022 to 2026

Remote Australian communities continue to experience persistent energy insecurity and increased greenhouse gas emissions due to their reliance on diesel-based microgrids. In response, this study presents a comprehensive techno-economic and environmental assessment of a hybrid renewable energy system integrating solar photovoltaics (PVs), wind turbines (WTs), battery energy storage systems (BESSs), and electric vehicles (Evs) with vehicle-to-home (V2H) functionality. Three system configurations are evaluated over a full-year simulation horizon using realistic solar irradiance, wind speed, household electricity demand, and driving profiles of electric vehicles: (i) off-grid (PV–WT–diesel generator (DG)), (ii) on-grid (PV–WT-BESS–Grid), and (iii) off-grid with V2H. System operation is coordinated …

A Global Imprint Of Gadolinium-Based Contrast Agents Used In Magnetic Resonance Imaging In Drinking Water, Vanessa Hatje, Franciele Castro Novais, Anna Maria Orani, Maria Elisabete Machado, Pere Masque, Marc Metian

Research outputs 2022 to 2026

Since the 1980s, rare earth elements (REE), particularly gadolinium (Gd) used in gadolinium-based contrast agents (GdCA), have revolutionized Magnetic Resonance Imaging (MRI) diagnostics. However, the near-complete persistence of these compounds through wastewater treatment processes has led to widespread global environmental contamination. Here, we present a global assessment of REE concentrations and GdCA signatures in tap water from 148 cities across 89 countries and Antarctica, where anthropogenic Gd ranges from 0.1 to 61.2 ng L–1 and accounts for up to 99% of total dissolved Gd. Contamination hotspots are concentrated in Europe and North America. While Gd levels scale with MRI usage …

Genedit: A Context-Aware Equity, Diversity And Inclusion Principles Integration Tool For Software Engineering Education, Chetan Arora, Ajanie Kodagoda Bammanna Arachchige, Jinchun Du, Muhammad Aamir Cheema, Aster Cosmos, Antonette Shibani, Vasudha Malhotra, Naeem Janjua, Afaq Shah

Research outputs 2022 to 2026

Equity, diversity and inclusion (EDI) is widely acknowledged as essential in software engineering (SE), yet day-to-day integration into teaching remains uncommon due to time pressures, low instructor confidence, and fragmented resources. We present GenEDIt, a purpose-built, LLM-backed chatbot that helps educators weave EDI into SE education artefacts without altering intended learning outcomes. Unlike generic chat interfaces, GenEDIt provides a tailored UI and workflow, and embeds retrieval over a vetted EDI knowledge base. The tool supports five educator-centred modes - (1) methods for integrating EDI into current activities; (2) examples/datasets; (3) EDI-integrated assessments and rubrics; (4) reflective prompts; and (5) rapid …

Differential Pro-Tumorigenic Effects Of Helicobacter Pylori And Streptococcus Anginosus On Ags Cells: Contact-Dependent Versus Metabolite-Driven Mechanisms, Luan Luan, Xiuling Song, Yunfei Zeng, Yunyun Xie, Yongxuan Hong, Jiawei Tang, Cong Ma, Bing Gu, Liang Wang

Research outputs 2022 to 2026

Gastric cancer remains a major global health burden, ranking fifth worldwide in both incidence and mortality. While Helicobacter pylori is a well-established Group I carcinogen, increasing evidence suggests that non-H. pylori bacteria, including Streptococcus anginosus, may also contribute to gastric carcinogenesis. However, their comparative pathogenic roles and interactions remain poorly defined. In this study, public databases showed stage-dependent abundance changes of H. pylori and S. anginosus but no significant correlation during gastric cancer progression. We further quantified both bacteria in gastric fluid samples collected from 500 individuals using a non-invasive gastric string test and in fecal samples from an independent …

Applying The Ottawa Charter To Evaluate Health Literacy Outcomes Of The Little Aussie Bugs Course For Australian Early Childhood Educators, Amelia Ruscoe, Elizabeth J. Cook, Eleanor K. O'Brien, Leesa N. Costello, Gillian Kirk, Ros Sambell, Theresa Rayfield, Amanda Devine, Ruth M. Wallace

Research outputs 2022 to 2026

Early childhood offers an important opportunity to lay the foundations for lifelong health literacy. The Little Aussie Bugs (LAB) dialogic book series and online professional development (PD) course were designed to support Early Childhood Education and Care (ECEC) educators to embed health literacy concepts, including hygiene, healthy eating, and oral health, into everyday learning routines. This mixed methods study evaluated the course pilot and examined its contribution through the lens of the Ottawa Charter for Health Promotion—a framework comprising five interrelated action areas: building healthy public policy; creating supportive environments; strengthening community action; developing personal skills; and reorienting health services. …

Sales Innovativeness Climate And B2b Salesperson Performance: The Roles Of Persistence, Entrepreneurial Self-Efficacy And Creative Selling, John Charles Peter Edwards, Steven Peter D'Alessandro, Morgan Miles

Research outputs 2022 to 2026

Purpose: Persistence is widely viewed as essential for success in business to business (B2B) selling, yet it remains unclear how persistence translates into higher sales performance when selling requires experimentation and novel customer solutions. This study examines whether a perceived sales innovativeness climate enables persistence and entrepreneurial self-efficacy (ESE) and, in turn, creative selling, driving B2B sales performance.

Design/methodology/approach: An online survey of 346 US-based B2B salespeople was analyzed using partial least squares structural equation modelling (PLS-SEM).

Findings: The perceived sales-innovativeness climate is positively associated with ESE, persistence, and sales performance. Persistence is positively related to sales performance and ESE, …

Transformative Phygital Service Research (Tpsr): An Agenda For Future Research, Saadia Shabnam, Sanjit K. Roy, Yonathan Silvain Roten, Gaganpreet Singh, Taewon Suh, Hairong Li

Research outputs 2022 to 2026

Purpose – This paper aims to develop a transformative phygital service research (TPSR) framework to explain how hybrid physical-digital service systems shape consumer well-being, autonomy, dignity and inclusion. While prior phygital service research (PSR) advances understanding of hybrid experiences and human-centred ecosystems, key ambiguities persist around agency, governance and interpretive labour in algorithmically mediated interactions. Existing frameworks address value co-creation but lack clarity on how digitally enforced rules and redistributed labour drive transformation. TPSR addresses this gap by theorising contradiction-driven processes through which human–AI arrangements and socio-technical dynamics produce both empowering and erosive outcomes in phygital service environments. Design/methodology/approach – …

The Effect Of Cyp1a2 Gene Polymorphisms On Caffeine Pharmacokinetics And Exercise Performance In Male Recreational Athletes, Chloe Masters, Ajmol Ali, Claire Badenhorst, Martin Dickens, Kay Rutherfurd-Markwick

Research outputs 2022 to 2026

This study examined the effects of caffeine consumption on endurance exercise performance, and the influence of CYP1A2 gene polymorphisms in caffeine pharmacokinetics and exercise performance. The data sets of two randomised, double blind, placebo-controlled crossover study design experiments have been merged. Thirty-eight recreationally active male participants provided saliva samples for CYP1A2 genotyping (AA homozygotes n = 19; AC heterozygotes n = 19) and completed either a 10-km run or 40-km cycling time trial of 60-min following a single dose of 6 mg·kg⁻¹ caffeine (CAF) or placebo (maltodextrin; PLA) throughout which heart rate (HR) and time to completion (TTC) were …

Introducing Contested Weather: Art And The Power Of Collaborative Response In Times Of Crisis, Jo Pollitt, Helena Grehan

Research outputs 2022 to 2026

No abstract provided.

Muscle–Tumor Crosstalk In Exercise Oncology: Exercise-Induced Myokines And Cancer Cachexia, Amirhossein Ahmadi Hekmatikar, Francesco Bettariga, Álvaro López Llorente, Diego Fernández-Lázaro, Katsuhiko Suzuki, D. Maryama Awang Daud

Research outputs 2022 to 2026

Exercise-induced myokines, such as IL-6, irisin, and myostatin, play crucial roles in mediating systemic adaptations and modulating tumor progression. This narrative review synthesizes evidence on how regular moderate-intensity exercise affects the myokine network within the tumor microenvironment (TME) of solid tumors. Results from the 86 included studies indicate that structured training (aerobic: 45–65% VO2 max; resistance: 45–70% 1RM) enhances the expression of beneficial myokines that support immune surveillance, reduce inflammation, and improve muscle–tumor cross-talk. IL-6 demonstrates a dual modulatory effect on inflammation and immunity; irisin contributes to tumor apoptosis, while myostatin downregulation supports muscle integrity and metabolic balance. Evidence suggests …

Advancing Dimensional Models Of Psychopathology In Cancer: Insights From Applying The Hierarchical Taxonomy Of Psychopathology (Hitop), Darren Haywood, Jai Carmichael, Miriam K. Forbes, Roman Kotov, Robert F. Krueger, Aidan G.C. Wright, Susan L. Rossell, David Castle, Wendy Lam, Maryam Lustberg, Colin E. Vize, Anna Ugalde, Phyllis Butow, Nicolas H. Hart

Research outputs 2022 to 2026

Objective: Cancer survivors, defined as those living with or beyond a cancer diagnosis, experience more than double the prevalence of psychopathology when compared to the general population. Categorical diagnostic systems, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), remain dominant in psycho-oncology despite concerns about reliability, validity, and clinical utility for this population. Dimensional frameworks, such as the Hierarchical Taxonomy of Psychopathology (HiTOP), offer a more precise alternative; however, they have not yet been widely applied in cancer survivors. Accordingly, the objective of this research was to examine the applicability of HiTOP to cancer survivors. Methods: Data …