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Research outputs 2022 to 2026

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Tourism Low-Carbon Decision-Making Through The Avoid–Shift–Improve Framework, Pezhman Hatamifar, Arghavan Hadinejad, Jalayer Khalilzadeh, Kourosh Esfandiar, S. Mostafa Rasoolimanesh Jan 2026

Tourism Low-Carbon Decision-Making Through The Avoid–Shift–Improve Framework, Pezhman Hatamifar, Arghavan Hadinejad, Jalayer Khalilzadeh, Kourosh Esfandiar, S. Mostafa Rasoolimanesh

Research outputs 2022 to 2026

Using the Avoid–Shift–Improve framework, this study examines how demographic factors and psychological, behavioral, and attitudinal drivers are associated with tourists’ low-carbon decision-making across mobility, consumption, and accommodation. Survey data were collected from 416 young Finnish travelers, and analyzed using correlation tests, repeated-measures ANOVA, and cluster segmentation to examine cross-domain and cross-strategy variation. Findings show that demographic factors have limited influence, whereas psychological, behavioral, and attitudinal drivers motivate sustainable choices. Shift dominant mobility decision-making, Avoid emergence in consumption, and Improve are most common in accommodation. Three adopter groups are identified as strong, moderate, and weak, reflecting different levels of engagement. Theoretically, …


Twelve Tips For Using Microlearning For Faculty Development, Kylie Fitzgerald, Brett Vaughan, Tamara Clements, Svetlana King, Alison Ledger, Kate Mathews, Rosalind Norton, Michael Poulton, Rosie Shea, Rashmi Watson, Walter Eppich, Stephen Trumble, Marco De Carvalho Filho Jan 2026

Twelve Tips For Using Microlearning For Faculty Development, Kylie Fitzgerald, Brett Vaughan, Tamara Clements, Svetlana King, Alison Ledger, Kate Mathews, Rosalind Norton, Michael Poulton, Rosie Shea, Rashmi Watson, Walter Eppich, Stephen Trumble, Marco De Carvalho Filho

Research outputs 2022 to 2026

Teaching is an expected as part of the health professional’s role, amidst clinical and administrative workloads, yet many receive limited education training. Microlearning addresses this gap through short, focused, flexible learning units integrated into daily workflows for immediate application. Our paper presents twelve practical tips to guide faculty developers to design, implement, evaluate and sustain microlearning programs for faculty development (FD). The tips offer ideas to help faculty developers manage common barriers to engagement (i.e. time, relevance, technology, institutional support) and provide ideas to navigate these. The tips are applicable to health professions education (HPE) settings seeking scalable, sustainable, low …


What Are Information Literacy Skills? Western Australian Primary Teachers’ Interpretations Of The Ict Curriculum, Louise Moroney, Vaille Dawson Jan 2026

What Are Information Literacy Skills? Western Australian Primary Teachers’ Interpretations Of The Ict Curriculum, Louise Moroney, Vaille Dawson

Research outputs 2022 to 2026

Teachers must equip students to navigate an increasingly complex world of unique challenges and opportunities, necessitating the development of a diverse range of transferable skills. These skills are embedded in the General Capabilities (GC) of the Australian school curriculum. Upper primary school teachers’ interpretations of one of the GC, Information and Communication Technology (ICT) learning progressions, was examined, as these skills have become increasingly important with the rise in generative and assistive artificial intelligence. Using an interpretivist paradigm, an exploratory study was used to determine the areas where 36 teachers differed in their interpretations of the learning progression. Data collected …


Analysis Of Geosynthetic-Reinforced Tailings Dam Slopes Subjected To Surface Loads, Francis Otieno, Sanjay Kumar Shukla Jan 2026

Analysis Of Geosynthetic-Reinforced Tailings Dam Slopes Subjected To Surface Loads, Francis Otieno, Sanjay Kumar Shukla

Research outputs 2022 to 2026

This study presents an extensive numerical investigation of the stability of a geosynthetic-reinforced tailings dam embankment slope subjected to surface loads from retained pyrite tailings slurry upstream of the dam. The analysis was performed on an embankment with an inclination of 1V:2.5H on the upstream slope and 1V:2H on the downstream slope. The dam embankment rests directly on previously deposited pyrite tailings that have dried over time and are sufficiently consolidated to support the embankment. The variable parameters considered in this study include the geosynthetic reinforcement length across the failure zone, effective cohesion (c′), effective angle of internal friction (ϕ′), …


Advancing Programmatic Assessment In Dietetics Through A Multi-Institutional Community Of Practice, Gemma Jenkins, Claire Palermo, Therese A. O'Sullivan, Alexander M. Clark, Leesa Costello Jan 2026

Advancing Programmatic Assessment In Dietetics Through A Multi-Institutional Community Of Practice, Gemma Jenkins, Claire Palermo, Therese A. O'Sullivan, Alexander M. Clark, Leesa Costello

Research outputs 2022 to 2026

Programmatic assessment has gained momentum in health professions education for its potential to address challenges in competency-based education. Yet, little is known about how to create the cultural and systemic changes needed for sector-wide enactment. This study used realist evaluation to develop and refine theory about how, why, and in what contexts a community of practice for Australian and New Zealand dietetic educators contributed to advancing programmatic assessment in dietetics higher education. Programme theory highlights the influence of committed, cross-institutional members, supported by an experienced and inclusive facilitator, on both the functioning and outcomes of the community of practice. Within …


Boodja First, Country First: Kaarl Ngaariny, Right Fire, Sandra Wooltorton, Len Collard, Oral Mcguire Jan 2026

Boodja First, Country First: Kaarl Ngaariny, Right Fire, Sandra Wooltorton, Len Collard, Oral Mcguire

Research outputs 2022 to 2026

How might belonging to Country guide us toward reciprocity, care and renewal in a time of breached planetary boundaries? Drawing on Noongar knowledge and the environmental humanities, this research paper explores how homes, gardens, farms, energy systems and investments are already entangled within Country, inviting a shift from separation to nurture. We propose that ideas around ownership, social mobility, comfort and growth shape suburban identities (including our own) and inhibit regenerative change. Within high-carbon economies such as Australia, ecological limits are often experienced as external constraints on human flourishing. When people recognise themselves as part of Country, however, limits can …


Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance And Plasma P-Tau181 Levels In Cognitively Unimpaired Older Adults, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Henrik Zetterberg, Nicholas J. Ashton, Manohar L. Garg, Kaj Blennow, Ralph N. Martins Jan 2026

Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance And Plasma P-Tau181 Levels In Cognitively Unimpaired Older Adults, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Henrik Zetterberg, Nicholas J. Ashton, Manohar L. Garg, Kaj Blennow, Ralph N. Martins

Research outputs 2022 to 2026

Emerging evidence suggests altered circulating metabolite levels in individuals with Alzheimer’s disease (AD) and/or mild cognitive impairment (MCI) compared to healthy controls; how these metabolites alter with early cortical amyloidosis—before symptom onset—remains unclear. This cross-sectional study aimed to investigate plasma metabolites obtained through targeted profiling using the Biocrates AbsoluteIDQ® p400 HR kit. The study cohort comprises 100 cognitively unimpaired (CU) older adults, stratified into CU Aβ− (negative positron emission tomography [PET]-amyloid-beta [Aβ]) and CU Aβ+ (positive PET-Aβ) groups. Significantly altered metabolites were further analysed for associations across amyloid plaque deposition, cognitive performance and plasma tau phosphorylated at threonine 181 (P-tau181) …


Clinicians’ Experiences And Perspectives On Robot-Assisted Lower Limb And Gait Neurorehabilitation In Western Australia: Robot-Assisted Lower Limb Neurorehabilitation, Nikki Bakhtazad, Amanda Timler, Matthew K. Bagg, Rachel Buckingham, Saran Chamberlain, Barbara Singer, Patricia Martinet, Taya Hamilton, Jodie Marquez, Stuart Hodgetts, Ann Maree Vallence, Eric Gaitho, Emma Gee, Jessica Nolan Jan 2026

Clinicians’ Experiences And Perspectives On Robot-Assisted Lower Limb And Gait Neurorehabilitation In Western Australia: Robot-Assisted Lower Limb Neurorehabilitation, Nikki Bakhtazad, Amanda Timler, Matthew K. Bagg, Rachel Buckingham, Saran Chamberlain, Barbara Singer, Patricia Martinet, Taya Hamilton, Jodie Marquez, Stuart Hodgetts, Ann Maree Vallence, Eric Gaitho, Emma Gee, Jessica Nolan

Research outputs 2022 to 2026

Purpose: Robot-assisted lower limb rehabilitation (RALLR) may be an effective adjunct to conventional therapy for those with neurological conditions. Robot-assisted rehabilitation is emerging in Western Australia (WA) and local perspectives on this technology have not been explored. This study aimed to explore perspectives of WA clinicians on RALLR, to inform further implementation.

Methods: This was a cross-sectional survey of neurorehabilitation clinicians across metropolitan WA. A subset of respondents completed semi-structured interviews. Transcripts were analysed thematically.

Results: Fifty-six clinicians (across four professions) completed the survey. Eleven participated in an interview. The majority of clinicians expressed interest in upskilling in rehabilitation robotics …


Controlled And Long-Term Multi-Drug Release From Silk Films, Christine Jurene O. Bacal, Pramod Dorishetty, Benjamin J. Allardyce, Nilupul Piyumantha, Fatemeh Ejeian, Amir Razmjou, Sharon Clark, Ruth Thornton, Filippo Valente Jan 2026

Controlled And Long-Term Multi-Drug Release From Silk Films, Christine Jurene O. Bacal, Pramod Dorishetty, Benjamin J. Allardyce, Nilupul Piyumantha, Fatemeh Ejeian, Amir Razmjou, Sharon Clark, Ruth Thornton, Filippo Valente

Research outputs 2022 to 2026

In this study, we propose a novel model of multi-layered, silk-based films for sustained and controlled release of multiple drugs for up to 25 days (600 h), with a prolonged tail-release phase extending to 45 days (1080 h), for biomedical applications. The compounds tested included ciprofloxacin (CIP, antibiotic) and dexamethasone (DEX, steroid) widely used in therapeutics formulations for the treatment of ear diseases like chronic otitis media. Using a layer-by-layer (LbL) assembly approach, sodium deoxycholate was also incorporated as a pH-sensitive, charge-interfacing agent between silk layers comprising of CIP or DEX, which proved critical in modulating interlayer interactions, enhancing drug …


Cost-Effective Design Of Home Energy Management System With Pv-Wind And Battery Storage In A Grid-Tied Microgrid, Md Mamun Ur Rashid, Jiefeng Hu, Md Alamgir Hossain, Md Shafiul Alam, Ismot Tasmary Salsabil, Bo Long Jan 2026

Cost-Effective Design Of Home Energy Management System With Pv-Wind And Battery Storage In A Grid-Tied Microgrid, Md Mamun Ur Rashid, Jiefeng Hu, Md Alamgir Hossain, Md Shafiul Alam, Ismot Tasmary Salsabil, Bo Long

Research outputs 2022 to 2026

The rising energy demand and the limited availability of traditional energy sources have driven the search for renewable energy alternatives. Over the past few years, more renewable energy sources and significant efforts have been carried out around the World to decrease carbon emissions in the utility sector. To support this development, microgrids have emerged as a smart component of the future power grid. Microgrids, powered by local energy resources, are the most effective for building the new power grid. In microgrids, an Energy Management System (EMS) is an essential element in scheduling the local energy flows. This paper focuses on …


Edible Coatings Application For Postharvest Fruits Preservation: Bibliometric Trends, Material Design, Physiological Mechanisms, And Safety Perspectives, Muslim Qadir, Navjot Kaur, Dali Vilma Francis, Abdelmoneim K. Abdalla, Zora Singh, Zienab F.R. Ahmed Jan 2026

Edible Coatings Application For Postharvest Fruits Preservation: Bibliometric Trends, Material Design, Physiological Mechanisms, And Safety Perspectives, Muslim Qadir, Navjot Kaur, Dali Vilma Francis, Abdelmoneim K. Abdalla, Zora Singh, Zienab F.R. Ahmed

Research outputs 2022 to 2026

Fresh fruits play a vital role in ensuring food and nutritional security, while also making significant contributions to global trade. However, due to their highly perishable nature, they are susceptible to postharvest losses during storage, transportation, and marketing. Edible coatings (ECs) and edible films are effective postharvest preservation technologies for retarding senescence and preserving fruit quality. This review provides a comprehensive update on recent developments in ECs and films aimed at reducing postharvest losses in fresh fruits. These coatings are formulated using biopolymers, including polysaccharides, proteins, and lipids, along with food-grade additives. The review discusses how ECs modulate postharvest physiology …


Ethical Positionings Of Risk And Harm For Adolescents Encountering Sexual Content Online, Lelia Green, Giselle Woodley, Carmen Jacques, Elisabeth Staksrud, Liza Tsaliki, Brian O’Neill, Debra Dudek, Despina Chronaki, Thuy Dinh, Kelly Jaunzems Jan 2026

Ethical Positionings Of Risk And Harm For Adolescents Encountering Sexual Content Online, Lelia Green, Giselle Woodley, Carmen Jacques, Elisabeth Staksrud, Liza Tsaliki, Brian O’Neill, Debra Dudek, Despina Chronaki, Thuy Dinh, Kelly Jaunzems

Research outputs 2022 to 2026

This paper interrogates the ethical complexities of talking with 12 to 17-year-olds about sexual content online. Authors were granted ethics approval by the Edith Cowan University Human Research Ethics Committee (2019-00583-GREEN) with three other participant countries translating Australian ethical protocols into their national contexts: Greece, Ireland and Norway. This paper addresses the four national contexts and examines the ethical issues arising for different countries’ ethics procedures when researchers conduct sensitive research with adolescents. Given widespread concern around the risk that children will be ‘sexualised’ by encountering sexual content online the ethical procedures adopted in each national context, and the way …


Exploring Factors That Influence Meal Management And Eating Behaviours In People Living With Huntington’S Disease, Joanna Rees, Ran Yan, Melanie Clark, Melanie Jolly, Alex Fisher, Amanda Devine, Simon M. Laws, Kelly Moes, Travis Cruickshank Jan 2026

Exploring Factors That Influence Meal Management And Eating Behaviours In People Living With Huntington’S Disease, Joanna Rees, Ran Yan, Melanie Clark, Melanie Jolly, Alex Fisher, Amanda Devine, Simon M. Laws, Kelly Moes, Travis Cruickshank

Research outputs 2022 to 2026

Purpose: People living with Huntington’s disease (pwHD) experience cognitive and motor changes that affect meal planning, preparation and food consumption. This study explored factors that influence meal management and eating behaviours of pwHD and their families.

Methods: This is a qualitative study employing semi-structured interviews and thematic analysis. Participants included gene-positive individuals living in Perth Western Australia, ranging from asymptomatic or experiencing subtle changes, to early to mid-stage HD.

Results: Nine individuals (mean age 47 ± 12.3 years) were interviewed for the study, including five gene-positive being asymptomatic or minimal symptoms. Seven themes were identified reflecting participants’ existing meal management …


Factors Influencing Clinician Escalation Practices For Deteriorating Patients In An Australian Emergency Department, Na Wang, Ruth Endacott, Simon Cooper, Clifford J. Connell Jan 2026

Factors Influencing Clinician Escalation Practices For Deteriorating Patients In An Australian Emergency Department, Na Wang, Ruth Endacott, Simon Cooper, Clifford J. Connell

Research outputs 2022 to 2026

Background: Physiological deterioration is typically identified through clinical signs and symptoms. There is a growing adoption of emergency department-specific responses to patient deterioration. Although the effectiveness of ward-based Rapid Response Systems is well-documented in the ‘failure-to-rescue’ literature and widely used in acute medical and surgical wards, their implementation and factors influencing failure-to-rescue in emergency department settings are less well understood.

Aim: To explore emergency nurses’ and doctors’ perceptions and experiences of escalation practices for deteriorating patients, including the factors influencing these practices, in an Australian ED.

Methods: A qualitative descriptive study using semi-structured interviews and Framework Analysis. Interviews were conducted …


How Perceived Empowerment And Place Attachment Drive Residents’ Support For Sustainable Tourism In Central Vietnam: A Serial Mediation Model, Phuong Kim Thi Tran, Nhi Thao Ho-Mai, Tuan Nien Tran, Vinh Trung Tran Jan 2026

How Perceived Empowerment And Place Attachment Drive Residents’ Support For Sustainable Tourism In Central Vietnam: A Serial Mediation Model, Phuong Kim Thi Tran, Nhi Thao Ho-Mai, Tuan Nien Tran, Vinh Trung Tran

Research outputs 2022 to 2026

From the Theory of Planned Behavior (TPB) and the Stimulus-Organism-Response (S–O–R) framework, this study proposes a serial mediation model to examine psychological drivers of residents’ support for sustainable tourism development (STD) in central Vietnam. Specifically, this study investigates how perceived empowerment and place attachment as stimulus influence residents’ attitudes (ATT), subjective norms (SN), and perceived behavioral control (PBC) as organism, which in turn shape their intentions to support STD as response. The study empirically surveyed 686 residents engaging with tourism services in three cities, namely Hue, Da Nang, and Quang Nam, in central Vietnam. This study utilised both online and …


Infant Formula Introduced Within 24 Hours Of Birth Increases Egg Allergy Risk, Jennie K. Nilsson, Summer V.M. Walker, Susan L. Prescott, Demelza J. Ireland, Sharon L. Perrella, Debra J. Palmer Jan 2026

Infant Formula Introduced Within 24 Hours Of Birth Increases Egg Allergy Risk, Jennie K. Nilsson, Summer V.M. Walker, Susan L. Prescott, Demelza J. Ireland, Sharon L. Perrella, Debra J. Palmer

Research outputs 2022 to 2026

Background: Breast secretions of colostrum precede milk production in the first few days after birth, providing nutrition and playing a critical role in shaping the newborn's gut microbiome and immune system development. Infants fed commercial milk formula in the first few days consume less colostrum, and previous studies have found an associated increased risk of food allergy.

Objective: To determine the risk of food allergen sensitization and IgE-mediated food allergy development in infants who received any formula during their first 3 days of life.

Methods: In a high-risk (defined by family history) cohort of 563 infants, born at 37 weeks’ …


Mental Health Professionals’ Perspectives On Essential Elements Of Telehealth Family Psychoeducation For Major Depressive Disorder: An Exploratory Study, Obumneke Obieche, Jing Yu Tan, Sita Sharma, Daniel Bressington, Tao Wang Jan 2026

Mental Health Professionals’ Perspectives On Essential Elements Of Telehealth Family Psychoeducation For Major Depressive Disorder: An Exploratory Study, Obumneke Obieche, Jing Yu Tan, Sita Sharma, Daniel Bressington, Tao Wang

Research outputs 2022 to 2026

Family-inclusive interventions, such as family psychoeducation (FPE), improve outcomes in major depressive disorder (MDD), particularly when tailored to the needs of individuals with MDD, their families, and carers. This study explored mental health professionals’ (MHPs) perspectives on the essential elements of telehealth FPE for MDD, including patients’ and their families’ informational and support needs. An exploratory cross-sectional study was conducted as part of the Supportive Program for Advancing Recovery, Knowledge, and Empowerment in Depression (SPARKED) research project, using an online questionnaire targeting MHPs within a regional area of Australia. Data analysis included descriptive statistics and quantitative and qualitative content analysis, …


Psag: Projection-Based Stabilized Attribution Guidance For Online Continual Learning, Hang Yu, Kun Hu, Zhuqiang Lu, Steven Qiang Lu, Zhiyong Wang, Fengxiang He Jan 2026

Psag: Projection-Based Stabilized Attribution Guidance For Online Continual Learning, Hang Yu, Kun Hu, Zhuqiang Lu, Steven Qiang Lu, Zhiyong Wang, Fengxiang He

Research outputs 2022 to 2026

Online Continual Learning (OCL) aims to incrementally learn from non-stationary data streams in a one-pass setting, facing the dual challenges of catastrophic forgetting and insufficient training. These challenges intensify the stability-plasticity dilemma, where pre-serving old knowledge conflicts with acquiring new information. In this paper, we propose Projection-based Stabilized Attribution Guidance (PSAG), a modular framework that leverages gradient-based attributions as active guidance signals to selectively preserve task-relevant representations. Our framework consists of three complementary mechanisms: (1) Attribution-Guided Feature Modulation (AGFM) that anchors critical features in the representation space; (2) Importance-Aware Loss Reweighting (IALR) that prioritizes informative samples at the loss level; …


Quantifying The Fatal And Non-Fatal Burden Of Disease Associated With Child Growth Failure, 2000–2023: A Systematic Analysis From The Global Burden Of Disease Study 2023, Gbd 2023 Child Growth Failure Collaborators, Amanuel Gebremedhin Jan 2026

Quantifying The Fatal And Non-Fatal Burden Of Disease Associated With Child Growth Failure, 2000–2023: A Systematic Analysis From The Global Burden Of Disease Study 2023, Gbd 2023 Child Growth Failure Collaborators, Amanuel Gebremedhin

Research outputs 2022 to 2026

Background: Child growth failure (CGF), which includes underweight, wasting, and stunting, is among the factors most strongly associated with mortality and morbidity in children younger than 5 years worldwide. Poor height and bodyweight gain arise from a variety of biological and sociodemographic factors and are associated with increased vulnerability to infectious diseases. We used data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 to estimate CGF prevalence, the risk of infectious diseases associated with CGF, and the disease mortality, morbidity, and overall burden associated with CGF.

Methods: In this analysis we estimated the all-cause and …


Raising Children In Precarious Spaces: Coping Strategies Of Young Mothers In Urban Slums Of Accra, Ghana, Portia Nana Ama Brempong, Samuel Eduaful, Kwabena Frimpong-Manso, Phoebe Afram Jan 2026

Raising Children In Precarious Spaces: Coping Strategies Of Young Mothers In Urban Slums Of Accra, Ghana, Portia Nana Ama Brempong, Samuel Eduaful, Kwabena Frimpong-Manso, Phoebe Afram

Research outputs 2022 to 2026

This study examined coping strategies of young mothers raising children in urban slum communities in Accra, Ghana. Guided by Jack’s Ecological Influences Framework and Interpretative Phenomenological Analysis, interviews were conducted with 20 young mothers aged 18–35 in Old Fadama and African Eleven. The findings revealed five strategies: spiritual coping and religious reliance; adaptive food management strategies; psychological endurance and emotional regulation; community-based support networks; and informal financial management and credit utilization. Environmental stressors, including crime and social disorder, shaped mothers’ parenting experiences and created tensions in transmitting values to their children. These findings suggest that young mothers’ coping strategies are …


Re-Thinking Bodies In Cross-Border Physical Education Teacher Education Policies: A Posthuman Perspective, Valeria Varea, Erik Backman Jan 2026

Re-Thinking Bodies In Cross-Border Physical Education Teacher Education Policies: A Posthuman Perspective, Valeria Varea, Erik Backman

Research outputs 2022 to 2026

While posthumanist studies have increased in Physical Education Teacher Education (PETE), traditional analytical approaches are still often employed for the analysis of policy documents, which limits the ways that we can understand policy work. The aim of this paper is to explore how bodies are conceptualised and assembled in PETE policies in one institution from Sweden and one from Australia using a posthumanist perspective. We understand these policies as material doings and enactments of the world that can allow us to think differently about PETE. By using the concepts of assemblage and plugging in, three result categories are presented: (1) …


The Alteplase Dose Assessment For Pleural Infection Therapy (Adapt) Study-3: Efficacy And Safety Of 1 Mg Alteplase As A Starting Intrapleural Dose, Estee P.M. Lau, Michaela Donaghy, Sam Faber, Sophie Krivinskas, Francesco Piccolo, Calvin Sidhu, Tommaso D'Orsogna, Sona Vekaria, Edward Fysh, Y. C. Gary Lee Jan 2026

The Alteplase Dose Assessment For Pleural Infection Therapy (Adapt) Study-3: Efficacy And Safety Of 1 Mg Alteplase As A Starting Intrapleural Dose, Estee P.M. Lau, Michaela Donaghy, Sam Faber, Sophie Krivinskas, Francesco Piccolo, Calvin Sidhu, Tommaso D'Orsogna, Sona Vekaria, Edward Fysh, Y. C. Gary Lee

Research outputs 2022 to 2026

Introduction: Intrapleural tissue plasminogen activator/deoxyribonuclease (tPA/DNase) therapy has revolutionised management of pleural infection. However, the optimal tPA dose is still unknown. The Alteplase Dose Assessment for Pleural infection Therapy (ADAPT) study-3 aims to evaluate the efficacy and safety of a lower starting intrapleural dose of 1 mg tPA (with 5 mg DNase) for pleural infection.

Methods: Consecutive patients with pleural infection who required intrapleural fibrinolytic therapy were treated with 1 mg tPA/5 mg DNase. Escalation of tPA doses were permitted at any time at the discretion of treating physicians.

Results: A total of 100 patients (22% female, mean age = …


Targeting Of The Oncogenic Fusion Ewsr1-Fli1 In Ewing Sarcoma By Crispr/Dcas9 Silencers, Shahama Taifour, Chee Wai Wong, Christopher Wallis, Edina Wang, Ash W.J. Tie, Eleanor Woodward, Charlene Waryah, Mahnaz Hosseinpour, Dilys Lam, Ryan Lister, Larissa Dymond, Andrew Woo, Peter J. Houghton, K. Swaminathan Iyer, Marck Norret, Cameron W. Evans, Louise Winteringham, Silvana Gaudieri, Pilar Blancafort Jan 2026

Targeting Of The Oncogenic Fusion Ewsr1-Fli1 In Ewing Sarcoma By Crispr/Dcas9 Silencers, Shahama Taifour, Chee Wai Wong, Christopher Wallis, Edina Wang, Ash W.J. Tie, Eleanor Woodward, Charlene Waryah, Mahnaz Hosseinpour, Dilys Lam, Ryan Lister, Larissa Dymond, Andrew Woo, Peter J. Houghton, K. Swaminathan Iyer, Marck Norret, Cameron W. Evans, Louise Winteringham, Silvana Gaudieri, Pilar Blancafort

Research outputs 2022 to 2026

Despite the revolutionary impact of genome engineering tools in medicine, the safe and effective intracellular delivery of CRISPR remains a major obstacle to clinical applications. Here, we utilize precision molecular targeting and delivery strategies based on CRISPR-nuclease-dead Cas9 (dCas9) systems adapted for epigenetic repression (dCas9-Krüppel-associated box [KRAB]) to silence oncogenic drivers with high selectivity. As proof of principle, we target the EWSR1-FLI1 translocation, which encodes a chimeric and hard-to-drug oncogenic transcription factor driving approximately 85% of the cases of Ewing sarcoma (EWS)—an aggressive childhood malignancy. We describe the development of a programmable, non-viral polymeric system for the delivery of dCas9-KRAB …


The Gender Gap In Writing: Gender Profiles For Paper- And Computer-Based Writing In Early Education, Anabela Malpique, Deborah Pino-Pasternak, Mustafa Asil Jan 2026

The Gender Gap In Writing: Gender Profiles For Paper- And Computer-Based Writing In Early Education, Anabela Malpique, Deborah Pino-Pasternak, Mustafa Asil

Research outputs 2022 to 2026

Research Findings: The gender gap in writing has received strong interest from literacy education and research, based on recurrent reports of gender differences in writing typically favoring female students. In this study, we investigated gender differences on paper- and computer-based text composing performance among early primary children (N = 544 Grade 2 students). Multilevel analyses revealed significant differences between boys and girls in both compositional quality and productivity across writing modalities. Specifically, boys consistently exhibited lower scores in both compositional quality and productivity compared to girls. Gender differences were notably influenced by various student-level factors such as handwriting automaticity, spelling …


When Dying Patients Fall Silent: How Nurses Navigate Decision-Making In The Last Days Of Life—A Qualitative Study, Tricia O'Connor, Aileen Collier, Karen Strickland, Carla Thamm, Catherine Paterson Jan 2026

When Dying Patients Fall Silent: How Nurses Navigate Decision-Making In The Last Days Of Life—A Qualitative Study, Tricia O'Connor, Aileen Collier, Karen Strickland, Carla Thamm, Catherine Paterson

Research outputs 2022 to 2026

Aim: To explore nurses' perspectives on decision-making processes and influencing factors when caring for unresponsive dying patients in the last days of life. Design: A qualitative interpretive study.

Methods: Using purposive recruitment and informal peer referral, twenty-one nurses from a specialist palliative care service in a metropolitan city in Australia were interviewed between July 2024 and January 2025. Data were analysed using reflexive thematic analysis. Decision-making theory was used as an interpretive lens.

Findings: Two themes were generated: ‘The patient as an absent presence’ and ‘Enacting agency through embodied cognition and relational attunement’, together with five interconnected subthemes. The analysis …


Wuthuga (Dugong) Population Status In Gathaagudu (Shark Bay) Sea Country, Holly Raudino, Amanda Hodgson, Chris Cleguer, Kym Reeve, Molly Moustaka, Osmar Luiz, Simone Strydom, Kathy Murray, Neilisha Oakley, Tariq Mcdonald, Abby Leyendekkers, Jay Hayes, Marlee Hutton, Julian A. Tyne, Kelly Waples Jan 2026

Wuthuga (Dugong) Population Status In Gathaagudu (Shark Bay) Sea Country, Holly Raudino, Amanda Hodgson, Chris Cleguer, Kym Reeve, Molly Moustaka, Osmar Luiz, Simone Strydom, Kathy Murray, Neilisha Oakley, Tariq Mcdonald, Abby Leyendekkers, Jay Hayes, Marlee Hutton, Julian A. Tyne, Kelly Waples

Research outputs 2022 to 2026

Introduction: Monitoring trends in wildlife populations and their response to pressures is integral but challenging for conservation managers. Wuthuga (dugongs (Dugong dugon)) are increasingly vulnerable as extreme climatic events, such as marine heatwaves and flooding, intensify with a warming climate and increasingly impact the seagrass they are dependent upon.

Methods: This study estimated wuthuga abundance using two methodologies: conventional observer aerial surveys, as part of a time-series of surveys, alongside aerial imagery, in Gathaagudu (Shark Bay), Western Australia in 2023. We compare the contemporary abundance estimates with long term monitoring data (1989 – 2018) to identify temporal trends in abundance …


Investigating Policy Enactment In Community Sport Coaching: Directions For Future Research, Ben Ives, Dawn Penney, Jimmy O’Gorman, Adam J. Nichol, Paul Potrac, Lee Nelson Jan 2026

Investigating Policy Enactment In Community Sport Coaching: Directions For Future Research, Ben Ives, Dawn Penney, Jimmy O’Gorman, Adam J. Nichol, Paul Potrac, Lee Nelson

Research outputs 2022 to 2026

This article calls for a sophisticated investigation of policy enactment in sport-related environments, with community sport coaching used as an example case. Emphasis is placed on the need for in-depth empirical research into and theorisation of: 1) political skills involved in the enactment of policy; 2) emotion management when enacting policy; 3) performative and fabricated aspects of policy enactment; and 4) impacts of policy enactment for the health and wellbeing of workers. In doing so, this article challenges scholars to move beyond the study of policy actor types and to develop more nuanced understandings of the political, economic, organisational, interpersonal, …


Managing Human Sources: Identification And Management Of Motivation, Tiffany Mckenzie, Pamela Henry, Nikki Rajakaruna Jan 2026

Managing Human Sources: Identification And Management Of Motivation, Tiffany Mckenzie, Pamela Henry, Nikki Rajakaruna

Research outputs 2022 to 2026

Human Source management is a critical function of intelligence and evidence collection by law enforcement and intelligence agencies across the world. Understanding the motivations of Human Sources is key to gaining high intelligence yields. Yet research which explores Human Source motivation, from a handler’s perspective, is limited. Even more limited is research which considers how motivation is identified and managed by law enforcement agencies across the course of a Human Source’s engagement with an agency. This research explores the experiences and perceptions of Human Source handlers from two Australian law enforcement agencies via semi-structured interviews (N = 17). Handlers highlighted …


I Am Still Concerned About Them: Grandmother Kinship Caregivers And The Challenge Of Abuse By Children In Their Care, Hajara Bentum, Vicki Banham, Kwadwo Adusei-Asante Jan 2026

I Am Still Concerned About Them: Grandmother Kinship Caregivers And The Challenge Of Abuse By Children In Their Care, Hajara Bentum, Vicki Banham, Kwadwo Adusei-Asante

Research outputs 2022 to 2026

Research evidence has shown that adverse occurrences within the kinship caregiving environment, such as the grandparents' experiences of violence and abuse, may introduce new stressors or exacerbate existing aged-related challenges, leading to adverse impacts on grandparent kinship carers. Yet no research has explored the impact of abuse and violence experienced by grandparent kinship caregivers from children in their care. This study involved narrative interviews with 31 grandmother kinship caregivers in Ghana to explore the adverse effects of the abuse they have experienced from children in their care. The study findings revealed the following impacts on grandmothers: (1) high blood pressure, …


Australian University Websites As Colonialities Of Gender, Emily M. Gray, Ampersand Pasley, Emma Fishwick, Mindy Blaise, Jacqueline Ullman, Maria Delaney Jan 2026

Australian University Websites As Colonialities Of Gender, Emily M. Gray, Ampersand Pasley, Emma Fishwick, Mindy Blaise, Jacqueline Ullman, Maria Delaney

Research outputs 2022 to 2026

This paper offers analysis of the first phase of a research project, Understanding and Addressing Everyday Sexisms in Australian Universities. This phase involved a critical content analysis of all 39 of Australia’s public university websites, focusing on how they represent gender, absences in relation to gender and the navigability of the websites in relation to gender equity policy. Drawing on Maria Lugones’s colonialities of gender, this paper demonstrates how university websites have the potential to reproduce or renegotiate inherited institutional everyday sexisms and broader gender inequities. Themes of reconfiguring acceptable gendering, conspicuous absences, and in-built obscurity that emerged from this …