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Caregiver Decision-Making Concerning Involuntary Treatment In Dementia Care At Home, Vincent Ra Moermans, Angela Mhj Mengelers, Michel Hc Bleijlevens, Hilde Verbeek, Bernadette Dierckx De Casterle, Koen Milisen, Elizabeth Capezuti, Jan Ph Hamers Dec 2021

Caregiver Decision-Making Concerning Involuntary Treatment In Dementia Care At Home, Vincent Ra Moermans, Angela Mhj Mengelers, Michel Hc Bleijlevens, Hilde Verbeek, Bernadette Dierckx De Casterle, Koen Milisen, Elizabeth Capezuti, Jan Ph Hamers

Publications and Research

Background: Dementia care at home often involves decisions in which the caregiver must weigh safety concerns with respect for autonomy. These dilemmas can lead to situations where caregivers provide care against the will of persons living with dementia, referred to as involuntary treatment. To prevent this, insight is needed into how family caregivers of persons living with dementia deal with care situations that can lead to involuntary treatment.

Objective: To identify and describe family caregivers’ experiences regarding care decisions for situations that can lead to involuntary treatment use in persons living with dementia at home.

Research design: A qualitative …


Neutron Activation Analysis Of Heavy Elements In The Environment, Le Van La, Vishwas Joshi Dec 2021

Neutron Activation Analysis Of Heavy Elements In The Environment, Le Van La, Vishwas Joshi

Publications and Research

The main focus of the research is: application of neutron activation analysis (NAA) to determine concentration and distribution of heavy metals in environmental samples. Due to human activity and industrialization, heavy metal pollutants have been accumulating in the environment. The heavy metal elements (such as: mercury (Hg), cadmium (Cd), arsenic (As), chromium (Cr), thallium (Tl), and lead (Pb)) tend to be toxic and their presence in the environment is problematic for plant, animal, and human health. The Neutron activation analysis (NAA) is one of nuclear techniques that has many useful applications such as bio-monitoring, biological analysis, environmental research and materials …


Lookism: An Examination Of Inequality In Appearance Within Diversity Practices, Hynndie Ozirus, Alyssa Dana Adomaitis Dec 2021

Lookism: An Examination Of Inequality In Appearance Within Diversity Practices, Hynndie Ozirus, Alyssa Dana Adomaitis

Publications and Research

During the formation of the United States, much of unification has centered on power and the privileged. This history is often painful to speak on in the communities with people of color. Rhodes (2010) discussed cultural injustices of being unattractive in a society appearance- obsessed with potential for “looks” to influence hiring practices, such as better career options and higher pay. The purpose of this was to investigate the issue of how lookism is defined and studied in the media especially in regards to people of color. The review of literature examines the relationship between income, education, as well as …


Comparative Analysis Of 3d Printed Denture Resins With Traditional Denture Materials At The Micro Level, Aneeza Hussain, Caleb Beckwith, Gaffar Gailani Dec 2021

Comparative Analysis Of 3d Printed Denture Resins With Traditional Denture Materials At The Micro Level, Aneeza Hussain, Caleb Beckwith, Gaffar Gailani

Publications and Research

The aim of this experiment was to evaluate and identify compression strength between traditionally manufactured acrylic dentures and additive manufacturing resin dentures. Specifically, the dentures produced by Uhler Dental, its Reveal line were compared against samples produced on the Formlabs Form 2 SLA, Stereolithography, 3D printer using their Denture Teeth A2 resin to test compression strength to assure they are compatible with the occlusal forces in the oral cavity. Using the ZwickRoell tensile testing machine, it appeared that the acrylic dentures were half as strong as the resin dentures. Then we went ahead to and did a comparative analysis under …


Investigating Project Success Factors In Post-Disaster Rebuilding Efforts In Nyc, Aalaa Mohammed, Jude R. Vallon, Calvin O. Walters Jr. Dec 2021

Investigating Project Success Factors In Post-Disaster Rebuilding Efforts In Nyc, Aalaa Mohammed, Jude R. Vallon, Calvin O. Walters Jr.

Publications and Research

On October 29, 2012, Superstorm Sandy caused nearly $19 billion in damages in New York City including damage to 69,000 residential units. A precipitated amount of roughly $4.2 billion in Community Development Block Grant was allocated towards PDR construction. These funds addressed a range of needs, including rebuilding and rehabilitating housing, assisting displaced tenants, and providing aid to businesses. Post-Disaster Rebuilding (PDR) is similar to construction in the modification of an existing facility that involves either renovation, additions, or subtractions to scopes of work to assist the overall performance of the facility. However, PDR goes further in a highly coordinated …


Factors Influencing Academic Self-Efficacy Among Nursing Students During Covid-19: A Path Analysis, Shinhi Han, Koun Eum, Hee Sun Kang, Kathleen Karsten Dec 2021

Factors Influencing Academic Self-Efficacy Among Nursing Students During Covid-19: A Path Analysis, Shinhi Han, Koun Eum, Hee Sun Kang, Kathleen Karsten

Publications and Research

Introduction: The shift to online learning owing to the coronavirus disease 2019 pandemic is posing an additional challenge to academic success, particularly for students who speak English as a Second Language (ESL). This study aimed to examine the factors that contribute to academic self-efficacy among ESL nursing students.

Method: This was a cross-sectional study using path analysis with 113 undergraduate ESL nursing students in New York City. Data were collected online using self-report measures of the study variables: academic self-efficacy, perfectionistic concerns, acculturative stress, and e-learning stress. A hypothetical path model was tested using AMOS 26.0.

Results: …


Memoria Y Fractura Social En El Ruido De Las Cosas Al Caer De Juan Gabriel Vásquez, Luis Mora-Ballesteros Dec 2021

Memoria Y Fractura Social En El Ruido De Las Cosas Al Caer De Juan Gabriel Vásquez, Luis Mora-Ballesteros

Publications and Research

El presente trabajo tiene como objetivos el análisis de algunas características de la memoria en la novela El ruido de las cosas al caer de Juan Gabriel Vásquez, establecer vínculos entre la novela y la narrativa de la sicaresca colombiana y caracterizar el trauma experimentado por algunos de sus personajes. Se trata de una novela con características que la incluyen dentro de la ficción contemporánea colombiana que a su vez forma parte de la sicaresca: un concepto clave sobre violencia, criminalidad, derechos humanos y narcotráfico expresados en la novela colombiana.


Expanding The Conceptualization Of Support In Low-Wage Carework: The Case Of Home Care Aides And Client Death, Emma K. Tsui, Marita Lamonica, Maryam Hyder, Paul Landsbergis, Jennifer Zelnick, Sherry Baron Dec 2021

Expanding The Conceptualization Of Support In Low-Wage Carework: The Case Of Home Care Aides And Client Death, Emma K. Tsui, Marita Lamonica, Maryam Hyder, Paul Landsbergis, Jennifer Zelnick, Sherry Baron

Publications and Research

Home care aides are a rapidly growing, non-standard workforce who face numerous health risks and stressors on the job. While research shows that aides receive limited support from their agency employers, few studies have explored the wider range of support that aides use when navigating work stress and considered the implications of these arrangements. To investigate this question, we conducted 47 in-depth interviews with 29 home care aides in New York City, focused specifically on aides’ use of support after client death. Theories of work stress, the social ecological framework, and feminist theories of care informed our research. Our analysis …


Textq—A User Friendly Tool For Exploratory Text Analysis, April Edwards, Marylyn Sullivan, Ezrah Itkowsky, Dana B. Weinberg Dec 2021

Textq—A User Friendly Tool For Exploratory Text Analysis, April Edwards, Marylyn Sullivan, Ezrah Itkowsky, Dana B. Weinberg

Publications and Research

As the amount of textual data available on the Internet grows substantially each year, there is a need for tools to assist with exploratory data analysis. Furthermore, to democratize the process of text analytics, tools must be usable for those with a non-technical background and those who do not have the financial resources to outsource their data analysis needs. To that end, we developed TextQ, which provides a simple, intuitive interface for exploratory analysis of textual data. We also tested the efficacy of TextQ using two case studies performed by subject matter experts—one related to a project on the detection …


Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie Dec 2021

Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie

Publications and Research

Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning , to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) …


Introduction: From Solidão, To Isolation, To Solidão-Rity, Luciane Ramos Silva, Tanya Saunders, Sarah S. Ohmer Dec 2021

Introduction: From Solidão, To Isolation, To Solidão-Rity, Luciane Ramos Silva, Tanya Saunders, Sarah S. Ohmer

Publications and Research

Solidão is a concept from Black Brazilian Gender Studies that does not have a US Black feminist or queer of color equivalent, nor does it translate into a single word in the English language. It describes shared isolation as an affective relational phenomenon with meanings as multiple as there are Black women. Solidão is inherent to the experiences of Black women considering the historical, social, and racial vectors that traverse individual experiences.

But how do you frame intersectional theory with Afro-Atlantic and African knowledge production outside of the United States? This is an introduction to the 2021 special issue of …


Book Review: Intercultural Perspectives On Research Writing, Edited By Pilar Mur-Dueñas And Jolanta Šinkūnienė (Amsterdam/Philadelphia: John Benjamins, 2018), David Sánchez-Jiménez Dec 2021

Book Review: Intercultural Perspectives On Research Writing, Edited By Pilar Mur-Dueñas And Jolanta Šinkūnienė (Amsterdam/Philadelphia: John Benjamins, 2018), David Sánchez-Jiménez

Publications and Research

No abstract provided.


God And Kant’S Suicide Maxim, Carlo Alvaro Dec 2021

God And Kant’S Suicide Maxim, Carlo Alvaro

Publications and Research

Kant’s argument against suicide is widely dismissed by scholars and often avoided by teachers because it is deemed inconsistent with Kant’s moral philosophy. This paper attempts to show a way to make sense of Kant’s injunction against suicide that is consistent with his moral system. One of the strategies adopted in order to accomplish my goal is a de-secularization of Kant’s ethics. I argue that all actions of self-killing (or suicide) are morally impermissible because they are inconsistent with God’s established nature and order. It is argued that the existence of God as the locus of moral value and duty …


Shhh-Tereotypes: A Conversation Among Librarians With Hearing Loss, Jill Cirasella, Lee Ann Fullington, Monica Berger, William Gargan Dec 2021

Shhh-Tereotypes: A Conversation Among Librarians With Hearing Loss, Jill Cirasella, Lee Ann Fullington, Monica Berger, William Gargan

Publications and Research

We are four hard of hearing librarians dependent on hearing aids. Our hearing loss complicates our work, often in ways that are not apparent to colleagues and patrons. In this article, based on our panel at the 2021 LACUNY Institute, we share our experiences, challenges, and self-accommodations, and offer suggestions for supporting and effectively communicating with hard of hearing colleagues.


Role Played By Edge-Defects In The Optical Properties Of Armchair Graphene Nanoribbons, Thi-Nga Do, Godfrey Gumbs, Danhong Huang, Bui D. Hoi, Po-Hsin Shih Nov 2021

Role Played By Edge-Defects In The Optical Properties Of Armchair Graphene Nanoribbons, Thi-Nga Do, Godfrey Gumbs, Danhong Huang, Bui D. Hoi, Po-Hsin Shih

Publications and Research

We explore the implementation of specific optical properties of armchair graphene nanoribbons (AGNRs) through edge-defect manipulation. This technique employs the tight-binding model in conjunction with the calculated absorption spectral function. Modification of the edge states gives rise to the diverse electronic structures with striking changes in the band gap and special flat bands at low energy. The optical-absorption spectra exhibit unique excitation peaks, and they strongly depend on the type and period of the edge extension. Remarkably, there exist the unusual transition channels associated with the flat bands for selected edge-modified systems. We discovered the special rule governing how the …


Plasmonic Field-Effect Transistors (Terafets) For 6g Communications, Michael Shur, Gregory Aizin, Taiichi Otsuji, Victor Ryzhii Nov 2021

Plasmonic Field-Effect Transistors (Terafets) For 6g Communications, Michael Shur, Gregory Aizin, Taiichi Otsuji, Victor Ryzhii

Publications and Research

Ever increasing demands of data traffic makes the transition to 6G communications in the 300 GHz band inevitable. Short-channel field-effect transistors (FETs) have demonstrated excellent potential for detection and generation of terahertz (THz) and sub-THz radiation. Such transistors (often referred to as TeraFETs) include short-channel silicon complementary metal oxide (CMOS). The ballistic and quasi-ballistic electron transport in the TeraFET channels determine the TeraFET response at the sub-THz and THz frequencies. TeraFET arrays could form plasmonic crystals with nanoscale unit cells smaller or comparable to the electron mean free path but with the overall dimensions comparable with the radiation wavelength. Such …


How Phantom Networks, Provider Qualities, And Poverty Sway Medicaid Dental Care Access: A Geospatial Analysis Of Manhattan, Destiny Kelley, Shipeng Sun Nov 2021

How Phantom Networks, Provider Qualities, And Poverty Sway Medicaid Dental Care Access: A Geospatial Analysis Of Manhattan, Destiny Kelley, Shipeng Sun

Publications and Research

Access to general dental care is essential for preventing and treating oral diseases. To ensure adequate spatial accessibility for the most vulnerable populations, New York State mandates a ratio of one general dentist to 2000 Medicaid recipients within 30 min of public transportation. This study employed geospatial methods to determine whether the requirement is met in Manhattan by verifying the online directories of ten New York managed care organizations (MCOs), which collectively presented 868 available dentists from 259 facilities. Our survey of 118 dental facilities representing 509 dentists revealed that significantly fewer dentists are available to treat Medicaid recipients compared …


Phylogenomics Of Alligator Lizards Elucidate Diversification Patterns Across The Mexican Transition Zone And Support The Recognition Of A New Genus, Christopher Blair, Robert W. Bryson Jr, Uri O. García-Vázquez, Adrián Nieto-Montes De Oca, David Lazcano, John E. Mccormack, John Klicka Nov 2021

Phylogenomics Of Alligator Lizards Elucidate Diversification Patterns Across The Mexican Transition Zone And Support The Recognition Of A New Genus, Christopher Blair, Robert W. Bryson Jr, Uri O. García-Vázquez, Adrián Nieto-Montes De Oca, David Lazcano, John E. Mccormack, John Klicka

Publications and Research

Genomic data continue to advance our understanding of species limits and biogeographic patterns. However, there is still no consensus regarding appropriate methods of phylogenomic analysis that make the best use of these heterogeneous data sets. In this study, we used thousands of ultraconserved element (UCE) loci from alligator lizards in the genus Gerrhonotus to compare and contrast species trees inferred using multiple contemporary methods and provide a time frame for biological diversification across the Mexican Transition Zone (MTZ). Concatenated maximum likelihood (ML) and Bayesian analyses provided highly congruent results, with differences limited to poorly supported nodes. Similar topologies were inferred …


The Aesthetic Legacy Of Evolution: The History Of The Arts As A Window Into Human Nature, Aaron Kozbelt Nov 2021

The Aesthetic Legacy Of Evolution: The History Of The Arts As A Window Into Human Nature, Aaron Kozbelt

Publications and Research

No abstract provided.


Oligomerization Of Mutant P53 R273h Is Not Required For Gain-Of-Function Chromatin Associated Activities, George K. Annor, Nour Elshabassy, Devon Lundine, Don-Gerard Conde, Gu Xiao, Viola Ellison, Jill Bargonetti Nov 2021

Oligomerization Of Mutant P53 R273h Is Not Required For Gain-Of-Function Chromatin Associated Activities, George K. Annor, Nour Elshabassy, Devon Lundine, Don-Gerard Conde, Gu Xiao, Viola Ellison, Jill Bargonetti

Publications and Research

The TP53 gene is often mutated in cancer, with missense mutations found in the central DNA binding domain, and less often in the C-terminal oligomerization domain (OD). These types of mutations are found in patients with the rare inherited cancer predisposition disorder called Li-Fraumeni syndrome. We previously found that mutant p53 (mtp53) R273H associates with replicating DNA and promotes the chromatin association of replication-associated proteins mini-chromosome maintenance 2 (MCM2), and poly ADP-ribose polymerase 1(PARP1). Herein, we created dual mutants in order to test if the oligomerization state of mtp53 R273H played a role in chromatin binding oncogenic gain-of-function (GOF) activities. …


Peer-Led Team Learning In Mathematics: An Effort To Address Diversity And Inclusion Through Learning And Leadership, Janet Liou-Mark, Melanie L. Villatoro, Ariane Masuda, Malika Ikramova, Farjana Shati, Julia Rivera, Victor Lee Nov 2021

Peer-Led Team Learning In Mathematics: An Effort To Address Diversity And Inclusion Through Learning And Leadership, Janet Liou-Mark, Melanie L. Villatoro, Ariane Masuda, Malika Ikramova, Farjana Shati, Julia Rivera, Victor Lee

Publications and Research

The Peer-Led Team Learning (PLTL) model has shown to be an effective instructional method to support females, underrepresented minorities, and first-generation students in Science, Technology, Engineering, and Mathematics (STEM). The collaborative problem-solving setting, led by a peer leader, fosters learning that engages all the students. There are six critical components that are vital to the PLTL model: 1) The PLTL Workshop is integral to the course; 2) Faculty is actively involved; 3) Peer Leaders are well trained; 4) The PLTL Workshop modules are challenging; 5) PLTL workshops are allocated time and space; and 6) There is institutional support. City Tech …


Guidance For Management Of Free-Roaming Community Cats: A Bioeconomic Analysis, Valeria A. Benka, John D. Boone, Philip S. Miller, Joyce R. Briggs, Aaron M. Anderson, Christopher Slootmaker, Margaret Slater, Julie K. Levy, Felicia B. Nutter, Stephen Zawistowski Nov 2021

Guidance For Management Of Free-Roaming Community Cats: A Bioeconomic Analysis, Valeria A. Benka, John D. Boone, Philip S. Miller, Joyce R. Briggs, Aaron M. Anderson, Christopher Slootmaker, Margaret Slater, Julie K. Levy, Felicia B. Nutter, Stephen Zawistowski

Publications and Research

Objectives This study used computer simulation modeling to estimate and compare costs of different free-roaming cat (FRC) management options (lethal and non-lethal removal, trap–neuter–return, combinations of these options and no action) and their ability to reduce FRC population abundance in open demographic settings. The findings provide a resource for selecting management approaches that are well matched for specific communities, goals and timelines, and they represent use of best available science to address FRC issues.

Methods Multiple FRC management approaches were simulated at varying intensities using a stochastic individual- based model in the software package Vortex. Itemized costs were obtained from …


Structure Of A Monomeric Photosystem Ii Core Complex From A Cyanobacterium Acclimated To Far-Red Light Reveals The Functions Of Chlorophylls D And F, Christopher J. Gisriel, Gaozhong Shen, Ming-Yang Ho, Vasily Kurashov, David A. Flesher, Jimin Wang, William H. Armstrong, John H. Golbeck, Marilyn R. Gunner, David J. Vinyard, Richard J. Debus, Gary W. Brudvig, Donald A. Bryant Nov 2021

Structure Of A Monomeric Photosystem Ii Core Complex From A Cyanobacterium Acclimated To Far-Red Light Reveals The Functions Of Chlorophylls D And F, Christopher J. Gisriel, Gaozhong Shen, Ming-Yang Ho, Vasily Kurashov, David A. Flesher, Jimin Wang, William H. Armstrong, John H. Golbeck, Marilyn R. Gunner, David J. Vinyard, Richard J. Debus, Gary W. Brudvig, Donald A. Bryant

Publications and Research

Far-red light (FRL) photoacclimation in cyanobacteria provides a selective growth advantage for some terrestrial cyanobacteria by expanding the range of photosynthetically active radiation to include far-red/near-infrared light (700–800 nm). During this photoacclimation process, photosystem II (PSII), the water:plastoquinone photooxidoreductase involved in oxygenic photosynthesis, is modified. The resulting FRL-PSII is comprised of FRL-specific core subunits and binds chlorophyll (Chl) d and Chl f molecules in place of several of the Chl a molecules found when cells are grown in visible light. These new Chls effectively lower the energy canonically thought to define the “red limit” for light required to drive photochemical …


The Nature Of Anti-Asian American Xenophobia During The Coronavirus Pandemic: A Preliminary Exploration Into Envy As A Key Motivator Of Hate, Daisuke Akiba Nov 2021

The Nature Of Anti-Asian American Xenophobia During The Coronavirus Pandemic: A Preliminary Exploration Into Envy As A Key Motivator Of Hate, Daisuke Akiba

Publications and Research

Background. The current Coronavirus pandemic has been linked to a dramatic increase in anti-Asian American and Pacific Islander (AAPI) hate incidents in the United States. At the time of writing, there does not appear to be any published empirical research examining the mechanisms underlying Asiaphobia during the current pandemic. Based on the stereotype content model, we investigated the idea that ambivalent attitudes toward AAPIs, marked primarily with envy, may be contributing to anti-AAPI xenophobia. Methods. Study 1 (N = 140) explored, through a survey, the link between envious stereotypes toward AAPIs and Asiaphobia. Study 2 (N = 167), …


Stimulating The Facial Nerve To Treat Ischemic Stroke: A Systematic Review, Turner S. Baker, Justin Robeny, Danna Cruz, Alexis Bruhat, Alfred-Marc Iloreta, Anthony Costa, Thomas James Oxley Nov 2021

Stimulating The Facial Nerve To Treat Ischemic Stroke: A Systematic Review, Turner S. Baker, Justin Robeny, Danna Cruz, Alexis Bruhat, Alfred-Marc Iloreta, Anthony Costa, Thomas James Oxley

Publications and Research

Acute ischemic stroke (AIS) is a common devastating disease that has increased yearly in absolute number of cases since 1990. While mechanical thrombectomy and tissue plasminogen activator (tPA) have proven to be effective treatments, their window-of-efficacy time is very short, leaving many patients with no viable treatment option. Over recent years there has been a growing interest in stimulating the facial nerves or ganglions to treat AIS. Pre-clinical studies have consistently demonstrated an increase in collateral blood flow (CBF) following ganglion stimulation, with positive indications in infarct size and neurological scores. Extensive human trials have focused on trans-oral electrical stimulation …


Needle In A Haystack: Detecting Subtle Malicious Edits To Additive Manufacturing G-Code Files, Caleb Beckwith, Harsh Sankar Naicker, Svara Mehta, Viba R. Udupa, Nghia Tri Nim, Varun Gadre, Hammond Pearce, Gary Mac Nov 2021

Needle In A Haystack: Detecting Subtle Malicious Edits To Additive Manufacturing G-Code Files, Caleb Beckwith, Harsh Sankar Naicker, Svara Mehta, Viba R. Udupa, Nghia Tri Nim, Varun Gadre, Hammond Pearce, Gary Mac

Publications and Research

Increasing usage of Digital Manufacturing (DM) in safety-critical domains is increasing attention on the cybersecurity of the manufacturing process, as malicious third parties might aim to introduce defects in digital designs. In general, the DM process involves creating a digital object (as CAD files) before using a slicer program to convert the models into printing instructions (e.g. g-code) suitable for the target printer. As the g-code is an intermediate machine format, malicious edits may be difficult to detect, especially when the golden (original) models are not available to the manufacturer. In this work we aim to quantify this hypothesis through …


Insights Into Using Plants In Management Of Viral Diseases., Vyacheslav Dushenkov, Anna Dushenkov Nov 2021

Insights Into Using Plants In Management Of Viral Diseases., Vyacheslav Dushenkov, Anna Dushenkov

Publications and Research

Botanical therapeutics possess a unique potential in the treatment of viral diseases. The pharmacological base and clinical use of botanical therapeutics have been extensively reviewed. The mode of action(s) may be built either on the direct interference with the virus's ability to enter human cells, virus replication, or exerting immune-modulatory and anti-inflammatory effects. The adjuvant treatment with botanical therapeutics has the potential to result in advances in symptom resolution, decrease in disease burden and shortening its duration.


Me3al-Mediated Domino Nucleophilic Addition/Intramolecular Cyclisation Of 2-(2-Oxo-2-Phenylethyl)Benzonitriles With Amines; A Convenient Approach For The Synthesis Of Substituted 1-Aminoisoquinolines, Krishna M. S. Adusumalli, Lakshmi N.S. Konidena, Hima B. Gandham, Krishnaiah Kumari, Krishan R. Valluru, Satya K.R. Nidasanametla, Venkateswara R. Battula, Hari K. Namballa Nov 2021

Me3al-Mediated Domino Nucleophilic Addition/Intramolecular Cyclisation Of 2-(2-Oxo-2-Phenylethyl)Benzonitriles With Amines; A Convenient Approach For The Synthesis Of Substituted 1-Aminoisoquinolines, Krishna M. S. Adusumalli, Lakshmi N.S. Konidena, Hima B. Gandham, Krishnaiah Kumari, Krishan R. Valluru, Satya K.R. Nidasanametla, Venkateswara R. Battula, Hari K. Namballa

Publications and Research

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2- phenylethyl)benzonitriles with amines in the presence of Me 3 Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good func- tional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the anti- tumor agent CWJ-a-5 in gram scale.


How Can I Get Covid?: Understanding Diferences In American Heterosexual And Sexual Minority Men’S Risk Perception, Devon M. Price, Amanda N. Gesselman, Rachel A. Fikslin, Alison J. Goldberg, Omaima Pervez, Mora A. Reinka, Elissia Franklin Nov 2021

How Can I Get Covid?: Understanding Diferences In American Heterosexual And Sexual Minority Men’S Risk Perception, Devon M. Price, Amanda N. Gesselman, Rachel A. Fikslin, Alison J. Goldberg, Omaima Pervez, Mora A. Reinka, Elissia Franklin

Publications and Research

Men are more vulnerable to COVID-19 infections compared to women, but their risk perceptions around COVID-19 are persis - tently lower. Further, men often engage in less health promotion behavior because self-care in this capacity is seen as weak or less masculine. This combination has consequences for mortality; thus, a better understanding of men’s COVID-19 cognitions and individual diference factors is critical. In a web-based survey conducted during the beginning stages of the pandemic in the U.S., we collected risk perceptions of various sexual and non-sexual behaviors from heterosexual ( n = 137) and gay/bisexual men ( n = 108). …


The Effect Of Body Mass Index On Brain Volume And Cognitive Function In Relapsing – Remitting Multiple Sclerosis: A Combirx Secondary Analysis, Aliza Bitton Ben-Zacharia, Malvin N. Janal, Abraham A. Brody, Jerry Wolinsky, Fred Lublin, Gary Cutter Nov 2021

The Effect Of Body Mass Index On Brain Volume And Cognitive Function In Relapsing – Remitting Multiple Sclerosis: A Combirx Secondary Analysis, Aliza Bitton Ben-Zacharia, Malvin N. Janal, Abraham A. Brody, Jerry Wolinsky, Fred Lublin, Gary Cutter

Publications and Research

BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume in MS.

OBJECTIVES: The purpose of this study was to examine the effects of BMI on normal appearing brain volume and cognitive function in patients with relapsing – remitting MS.

METHODS: A secondary data analysis of the NIH CombiRx study was conducted. Multivariate regression and mixed model analyses were executed to analyze …