Digital Commons Network^™

Structure–Activity Relationship Studies On 6-Chloro-1-Phenylbenzazepines Leads To The Identification Of A New Dopamine D1 Receptor Antagonist, Rajan Giri, Hari K. Namballa, Vishwashiv Emogaje, Wayne W. Harding

Publications and Research

The 1-phenylbenzazepine template has yielded a number of D1R-like ligands, which, though useful as pharmacological tools, have significant drawbacks in terms of selectivity versus D5R as well as pharmacokinetic behavior. A number of 1-phenylbenzazepines contain a 6-chloro functional group, but extensive SAR studies around the 6-chloro-1-phenylbenzazepine framework have not been reported in the literature. To further understand the tolerance of the 6-chloro-1-phenylbenzazepine template for various substituent groups towards affinity and selectivity at D1R, we synthesized two series of analogs with structural variations at the C-7, C-8, N-3, C-3′ and C-4′ positions. The series 2 analogs differed from …

Tcga Expression Analyses Of 10 Carcinoma Types Reveal Clinically Significant Racial Differences, Brian Lei, Xinyin Jiang, Anjana Saxena

Publications and Research

Epidemiological studies reveal disparities in cancer incidence and outcome rates between racial groups in the United States. In our study, we investigated molecular differences between racial groups in 10 carcinoma types. We used publicly available data from The Cancer Genome Atlas to identify patterns of differential gene expression in tumor samples obtained from 4112 White, Black/African American, and Asian patients. We identified race-dependent expression of numerous genes whose mRNA transcript levels were significantly correlated with patients’ survival. Only a small subset of these genes was differentially expressed in multiple carcinomas, including genes involved in cell cycle progression such as CCNB1 …

Changes To Sea Surface Temperatures And Vertical Wind Shear And Their Influence On Tropical Cyclone Activity In The Caribbean And The Main Developing Region, Keneshia Hibbert, Equisha Glenn, Thomas M. Smith, Jorge E. González-Cruz

Publications and Research

Sea surface temperatures and vertical wind shear are essential to tropical cyclone formation. TCs need warm SSTs and low shear for genesis. Increasing SSTs and decreasing VWS influences storm development. This work analyzes SST and VWS trends for the Caribbean, surrounding region, and the Atlantic hurricane main developing region from 1982–2020. Storm intensity increases significantly during this period. Annual and seasonal trends show that regional SSTs in the MDR are warming annually at 0.0219 °C yr⁻¹ and, per season, 0.0280 °C yr⁻¹. Simultaneously, VWS decreases during the late rainfall season, at 0.056 m/s yr⁻¹ in the …

Radiation-Induced Gastrointestinal (Gi) Syndrome As A Function Of Age, Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman

Publications and Research

Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher levels of apoptotic stem cells in small intestinal crypts that correlated with sphingomyelinase activity, a source of pro-apoptotic ceramide. The objective of this study is to determine whether the cycling crypt base columnar cells (CBCs) in aging animals are specifically more sensitive to radiation effects than the CBCs in young adult mice, and to identify factors that contribute to increased radiosensitivity. Mortality induced by subtotal body radiation was …

Automated Morphological Phenotyping Using Learned Shape Descriptors And Functional Maps: A Novel Approach To Geometric Morphometrics, Oshane O. Thomas, Hongyu Shen, Ryan L. Raaum, William E. H. Harcourt-Smith, John D. Polk, Mark Hasegawa-Johnson

Publications and Research

The methods of geometric morphometrics are commonly used to quantify morphology in a broad range of biological sciences. The application of these methods to large datasets is constrained by manual landmark placement limiting the number of landmarks and introducing observer bias. To move the field forward, we need to automate morphological phenotyping in ways that capture comprehensive representations of morphological variation with minimal observer bias. Here, we present Morphological Variation Quantifier (morphVQ), a shape analysis pipeline for quantifying, analyzing, and exploring shape variation in the functional domain. morphVQ uses descriptor learning to estimate the functional correspondence between whole triangular meshes …

Lead Induced Differences In Bone Properties In Osteocalcin +/+ And −/− Female Mice, G. Yildirim, W. C. Budell, O. Berezovska, S. Yagerman, S. S. Maliath, P. Mastrokostas, S. Tommasini, T. L. Dowd

Publications and Research

Lead (Pb) toxicity is a major health problem and bone is the major reservoir. Lead is detrimental to bone, affects bone remodelingand is associated with elderly fractures. Osteocalcin (OC) affects bone remodeling, improves fracture resistance and decreases with age and in some diseases. The effect of lead in osteocalcin depleted bone is unknown and of interest. We compared bone mineral properties of control and Pb exposed (from 2 to 6 months) femora from female adult C57BL6 OC+/+ and OC−/− mice using Fourier Transform Infrared Imaging (FTIRI), Micro-computed tomography (uCT), bone biomechanical measurements and serum turnover markers (P1NP, CTX). Lead significantly …

Feeling Analogue: Using Modular Synthesizers, Designing Synthesis Communities, Eliot Bates

Publications and Research

When Harald Bode nominally invented the modular synthesiser in 1960, it was not yet clear whether it was a musical instrument or a less-defined form of studio-sited audio technology (Subotnik 1970). Much of the technology, from the interface design to the specific parts, was shared with nonmusical test and measurement equipment. Sixty years later, hardware modular synthesis is used not just for musical creation but for noise, sound art and data sonification/visualization. Through an ethnographic study of the design and use of the Eurorack modular synthesis format, and of modular synthesis maker and user communities spread through North America, Europe …

La Descortesía En Los Comentarios Digitales De La Prensa Deportiva. El Tenis, Mucho Más Que Un Juego, David Sánchez-Jiménez

Publications and Research

Comments on sports news published on the digital platforms of newspapers have turned these spaces into forums for debate in which homogeneous social communities are established. The aim of this research is to find out how the participants of these platforms interact in the sports press and what impoliteness strategies they use when evaluating the text of the news and the comments of other users. For this purpose, a qualitative textual analysis of a corpus of 1,000 digital comments produced on the Australian Open 2022 final in four of the most widely distributed Spanish newspapers with the highest national circulation, …

Insights: Qualitative Study To Reevaluate And Redesign Online Learning Self-Guided Tools For English First Year Writers Learning Self-Guided Tools For English First Year Writers, Nandi Prince

Publications and Research

The library faculty teaches approximately three hundred one-time instructional classes per year. This study explored the role of the library instructor in support of serving the needs of first-year writers (FYW) in a discourse community (DC). The English faculty teach English Composition I, the FYW develop their writing skills in a community with shared goals and an established means of communicating. This qualitative study explored: (1) in-depth experiences of the English faculty during library one-time instructional classes; (2) their perceptions of what students need most, in the new curriculum; (3) new findings that would guide the design of digital tools …

Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra N. Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jodi-Ann Douglas

Publications and Research

Radiology departments have contributed significantly to greenhouse gases including release of toxic imaging contrast media to environment. We feel Radiology also has several spectroscopy and imaging tools that may apply to monitor and support cleaner environmental goals. The current manuscript is one of the firsts to prompt Radiology to move in that direction by non invasive imaging of bio metals that are less abundant in biological tissues but play key roles as co-factors in tissue structure and function. Conventional analytical tools are mostly invasive and cannot characterize the native oxidation states of bio metals. We chose carbohydrate matrix of metal-rich …

Lookism, Social Media, Beauty Prejudice, Diana Saiki, Alyssa Dana Adomaitis

Publications and Research

"Lookism” is a term to describe appearance discriminationor “the practice of discrimination on the basis of physical appearance in the workplace” (Ghodrati, Joorabchi, & Muati, 2015, p.1). In popular literature, it has been called “beauty prejudice” (Etcoff, 1999, p. 1). The notion that a pleasing appearance results in favorable outcomes (e.g., higherwages, promotions) from others is not necessarily new, as literature on physical attractiveness is rather extensive. The Washington Post Magazine first used the term “lookism” in 1978 (e.g., Ayto, 1999), however, the term “lookism” was first recognized as a form of discrimination by authors of the Oxford English Dictionary …

Opportunities In Study Abroad: Planning, Steps And Suggestions, Diana Saiki, Alyssa Dana Adomaitis

Publications and Research

Faculty lead field studies are supported at most universities, but they can be time consuming and daunting to plan. The benefits of study abroad experiences have been well documented (Livingmore, 2011). There is growing evidence that short term faculty lead field studies provide a positive outlook on the fashion industry (Boorady, et al., 2016). Furthermore, these experience enhance students’“cultural intelligence” or the ability to communicate with diverse cultures and work well in diverse cultural settings (e.g., Livermore, 2011, Rolling,Presley, & Thornton, 2018). There is some literature on faculty lead international experiences study the apparel industry, such as El Salvador (e.g.Ha-Brookshire,2008). …

Standard Deviations Of Mr Signal Intensities Show A Consistent Trend During Imaging Follow-Ups For Glioblastoma Patients When Corrected For Non-Biological Heterogeneity Due To Hardware And Software Variation, Subhendra N. Sarkar, Rafael Rojas, Evans Lespinasse, Xiangfu Zhang, Ruth Zeron

Publications and Research

Introduction

Glioblastoma multiforme (GBM) has a poor prognosis in spite of advanced MRI guided treatments today. Routine MRI using conventional T₁ or advanced permeability based MRI of GBM often does not adequately represent changing tumor phases or overall survival. In this work, region of interest (ROI) based tissue MR standard deviation (SD) is demonstrated as an important MRI variable that could be a potential biomarker of GBM heterogeneity and radioresistance.

Materials and methods

MRI characterization is often qualitative and lacks reproducibility. Using standardized MRI phantoms we have normalized retrospective records of 12 radioresistant GBM patients that underwent radiation therapy …

Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jody-Ann Douglas

Publications and Research

Radiology departments have contributed significantly to greenhouse gases including release of toxic imaging contrast media to environment. We feel Radiology also has several spectroscopy and imaging tools that may apply to monitor and support cleaner environmental goals. The current manuscript is one of the firsts to prompt Radiology to move in that direction by non-invasive imaging of bio metals that are less abundant in biological tissues but play key roles as co-factors in tissue structure and function. Conventional analytical tools are mostly invasive and cannot characterize the native oxidation states of bio metals. We chose carbohydrate matrix of metal-rich fruits …

Mathematics Preparatory Workshops To Foster Student Success, Sandie Han, Diana Samaroo, Janet Liou-Mark, Lauri Aguirre

Publications and Research

Mathematics preparatory workshops were offered to college students at a diverse urban undergraduate institution. The goal was to prepare students for their mathematics course, by offering non-credit bearing and free preparatory workshops. The lack of adequate preparation for mathematics courses is a barrier for student engagement in future STEM courses. We believe that by providing preparatory workshops, we can improve not only the success but access for students in foundational mathematics courses. The workshops allowed students to engage with the course content in a rigorous and intensive manner prior to the start of the semester. Students who participated in the …

Perspectives On Determinism In Quantum Mechanics: Born, Bohm, And The “Quantal Newtonian” Laws, Viraht Sahni

Publications and Research

Quantum mechanics has a deterministic Schrödinger equation for the wave function. The Göttingen–Copenhagen statistical interpretation is based on the Born Rule that interprets the wave function as a “probability amplitude.” A precept of this interpretation is the lack of determinism in quantum mechanics. The Bohm interpretation is that the wave function is a source of a field experienced by the electrons, thereby attributing determinism to quantum theory. In this paper, we present a new perspective on such determinism. The ideas are based on the equations of motion or “Quantal Newtonian” Laws obeyed by each electron. These Laws, derived from …

Correlation Of Road Network Structure And Urban Mobility Intensity: An Exploratory Study Using Geo-Tagged Tweets, Li Geng, Ke Zhang

Publications and Research

Urban planners have been long interested in understanding how urban structure and activities are mutually influenced. Human mobility and economic activities naturally drive the formation of road network structure and the accessibility of the latter shapes the patterns of movement flow across urban space. In this paper, we perform an exploratory study on the relationship between the street network structure and the intensity of human movement in urban areas. We focus on two cities and we utilize a dataset of geo-tagged tweets that can form a proxy to urban mobility and the corresponding street networks as obtained from OpenStreetMap. We …

Occupational Depression In Italy: Associations With Health, Economic, And Work-Life Characteristics, Renzo Bianchi, Caterina Fiorilli, Giacomo Angelini, Nicoletta Dozio, Carlo Palazzi, Gloria Palazzi, Benedetto Vitiello, Irvin Sam Schonfeld

Publications and Research

Background: The Occupational Depression Inventory (ODI) reflects a new approach to job-related distress centered on work-attributed depressive symptoms. The instrument was developed with reference to the characterization of major depression found in the DSM-5. The ODI has been validated in English, French, and Spanish. This study (a) investigated the psychometric and structural properties of the ODI’s Italian version and (b) inquired into the nomological network of occupational depression. Methods: A convenience sample of 963 employed individuals was recruited in Italy (69.9% female; mean age = 40.433). We notably relied on exploratory structural equation modeling bifactor analysis, common-practice …

Effectiveness And Safety Of Direct Oral Anticoagulants Among Patients With Non-Valvular Atrial Fibrillation And Multimorbidity, Amol Dhamane, Mauricio Ferri, Allison V. Keshishian, Cristina Russ, Nipun Atreja, Cynthia Gutierrez, Birol Emir, Huseyin Yuce, Manuela Di Fusco

Publications and Research

Introduction

In the USA, there is a steady rise of atrial fibrillation due to the aging population with increased morbidity. This study evaluated the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) among elderly patients with non-valvular atrial fibrillation (NVAF) and multimorbidity prescribed direct oral anticoagulants (DOACs).

Methods

Using the CMS Medicare database, a retrospective observational study of adult patients with NVAF and multimorbidity who initiated apixaban, dabigatran, or rivaroxaban from January 1, 2012 to December 31, 2017 was conducted. High multimorbidity was classified as having ≥ 6 comorbidities. Cox proportional hazard models were used to evaluate the hazard …

Open Educational Resources Adoption Reduces Textbook Costs Without Sacrificing Student Performance In Business And Economics Courses At A Community College, Dorina Tila, Dawn Levy

Publications and Research

This study analyzed the possibility of saving on textbook costs without sacrificing student performance by using Open Educational Resources (OER) at no cost to students as a replacement for high-priced commercially printed books. Approximately two hundred students enrolled in business and economics courses at Kingsborough Community College of the City University of New York from Fall 2016 to Fall 2018 were assessed in this study. Using summative assessments and course grades as a measure of students’ performance, the findings showed that students in courses using OER as compared to students in the same subject area using traditional textbooks perform equally …

​​Pr 101: A Resource For New Public Relations Professionals, Ilana M. Weinberger

Publications and Research

The field of public relations (PR) is often misunderstood, despite the fact that it is a growing field (Fawkes, 2018). New employees enter the field of PR every year, whether as new graduates or as those making a career change, yet the intricacies of working in PR are not generally taught in the classroom (Meganck, Smith & Guidry, 2020). Most people do not have a solid understanding of what PR professionals do on a day-to-day basis, and in fact, many of those entering the field don’t either. They may think that PR is simply social media management, or even confuse …

Spatial Metaphors In Introductory Statements Of Humanities And Stem Disciplines: A Study Of English And Mechanical Engineering Departments, Olalekan T. Adepoju

Publications and Research

Advances in higher education, specifically in science and technology, have engendered a significant shift of interest from a mainly liberal arts curriculum to STEM-related fields of study, creating a rift in the value systems undergirding the two academic domains. One of the ways the disciplinary disparity is institutionally expressed is through the language used in describing the core values of these disciplines, specifically in the introductory statements of departments. Using the lens of spatial metaphor to consider how the language expresses distinct realities that align with the public perceptions of the disciplines, this paper examines the metaphorical framings in the …

The Paradox Of Plenty: Why Guyana’S Local Content Law Needs A Reality Check, Vivian M. Williams

Publications and Research

The effectiveness of coercive local content requirements to the development of resource rich developing countries is an area attracting increasing global attention. Local content requirements are especially popular in the extractive sector though empirical studies show that they do not fulfill their intended purpose. Now recognized as the world's fastest growing economy after becoming an oil producing country, Guyana has passed a local content law. The real concern is not merely whether local content requirements fail to fulfill their objectives but whether they create market distortions that lead to the resource curse. This issue was addressed by Baruch's Adjunct Assistant …

Standard Deviations Of Mr Signal Intensities Show A Consistent Trend During Imaging Follow-Ups For Glioblastoma Patients When Corrected For Non-Biological Heterogeneity Due To Hardware And Software Variation, Subhendra N. Sarkar, Rafael Rojas, Evans Lespinasse, Xiang Fu Zhang, Ruth Zeron

Publications and Research

Introduction: Glioblastoma multiforme (GBM) has a poor prognosis in spite of advanced MRI guided treatments today. Routine MRI using conventional T1 or advanced permeability based MRI of GBM often does not adequately represent changing tumor phases or overall survival. In this work, region of interest (ROI) based tissue MR standard deviation (SD) is demonstrated as an important MRI variable that could be a potential biomarker of GBM heterogeneity and radioresistance. Materials and methods: MRI characterization is often qualitative and lacks reproducibility. Using standardized MRI phantoms we have normalized retrospective records of 12 radioresistant GBM patients that underwent radiation therapy (RT) …

Digital Humanities At Work In The World, Sarah Ruth Jacobs

Publications and Research

No abstract provided.

Implementing Oer At Laguardia Community College: Three Case Studies, Ian Mcdermott, Joshua P. Tan, Alioune Khoule, Marta Kowalczyk, Emma Handte, Rena D. Grossman

Publications and Research

LaGuardia Community College, City University of New York (CUNY) began receiving funds from a New York State Open Educational Resources (OER) grant in 2017. Since then, several departments have made significant strides in the implementation of OER. We offer three case studies of putting OER into practice, in math, astronomy, and chemistry. Each case study presents the context for OER conversion, the steps taken, early results from OER implementation, and the main takeaways. A common feature across courses and departments is a process-oriented implementation of OER, namely, one that is constantly improving and moving towards the goal of openness and …

Coping With Constant Obsolescence: A Lifelong Task, Di Su

Publications and Research

Knowledge and skill obsolescence is a common obstacle in individual, organization, and society development. Thanks to the modern technologies, the rate of obsolescence accelerates rapidly in the information age. In the library workplace, obsolescence occurs constantly. We may be used to routines, but changes are inevitable as we have witnessed the evolution in library services and librarian workplace since the advent of the internet. To cope with obsolescence, it is crucial to have a lifelong learning mindset, make it a habit, and find ways to update our knowledge and skills to stay competent and serve the clientele effectively.

Exploring Dante’S Sources Online: Interactive Reading, Visualizations, And The Study Of Dantean Intertextuality In The Digital Age, Julie Van Peteghem

Publications and Research

Dante’s Commedia is a highly allusive text, and readers throughout time have noted the many parallels between Dante’s verses and those of others. Now that the text of the Commedia and various scholarly and artistic interpretations of the poem (commentaries, translations, illuminated manuscripts) have become accessible online, also the concordance, the lists of parallel passages in Dante’s poem and other works, has become a digital resource. In this essay I explore the study of Dante’s sources in a digital environment mainly through the Intertextual Dante project and its Dante-Ovid edition, published on Digital Dante. Intertextual Dante visualizes moments of …

Single-Cell Approach Reveals Intercellular Heterogeneity In Phage-Producing Capacities, Sherin Kannoly, Gabriella Oken, Jonathan Shadan, David Musheyev, Kevin Singh, Abhyudai Singh, John J. Dennehy

Publications and Research

Bacteriophage burst size is the average number of phage virions released from infected bacterial cells, and its magnitude depends on the duration of an intracellular progeny accumulation phase. Burst size is often measured at the population level, not the single-cell level, and consequently, statistical moments are not commonly available. In this study, we estimated the bacteriophage lambda (ƛ) single-cell burst size mean and variance following different intracellular accumulation period durations by employing Escherichia coli lysogens bearing lysis-deficient ƛ prophages. Single lysogens can be isolated and chemically lysed at desired times following prophage induction to quantify progeny intracellular accumulation within individual …

Coupled Spherical-Cavities, Stanislav Kreps, Vladimir Shuvayev, Mark Douvidzon, Baheej Bathish, Tom Lenkiewicz Abudi, Amirreza Ghaznavi, Jie Xu, Yang Lin, Lev Deych, Tal Carmon

Publications and Research

In this work, we study theoretically and experimentally optical modes of photonic molecules—clusters of optically coupled spherical resonators. Unlike previous studies, we do not use stems to hold spheres in their positions relying, instead on optical tweezers to maintain desired structures. The modes of the coupled resonators are excited using a tapered fiber and are observed as resonances with a quality factor as high as 107. Using the fluorescent mapping technique, we observe families of coupled modes with similar spatial and spectral shapes repeating every free spectral range (a spectral separation between adjacent resonances of individual spheres). Experimental results are …