Digital Commons Network^™

A Paradigm For Peptide Hormone-Gpcr Analyses, Fred Naider, Jeffrey M. Becker

Publications and Research

Work from our laboratories over the last 35 years that has focused on Ste2p, a G protein-coupled receptor (GPCR), and its tridecapeptide ligand α-factor is reviewed. Our work utilized the yeast Saccharomyces cerevisiae as a model system for understanding peptide-GPCR interactions. It explored the structure and function of synthetic α-factor analogs and biosynthetic receptor domains, as well as designed mutations of Ste2p. The results and conclusions are described using the nuclear magnetic resonance interrogation of synthetic Ste2p transmembrane domains (TMs), the fluorescence interrogation of agonist and antagonist binding, the biochemical crosslinking of peptide analogs to Ste2p, and the phenotypes of …

Association Of Body Shape Index (Absi) With Hand Grip Strength, Nir Y. Krakauer, Jesse C. Krakauer

Publications and Research

Hand grip is a leading measure of muscle strength and general health, yet its association with body shape is not well characterized. Here, we examine correlations between grip strength, a body shape index (ABSI), and body mass index (BMI) in the 2011–2014 United States National Health and Nutrition Examination Survey cohorts. Grip strength was found to correlate negatively with ABSI (though positively with BMI), suggesting that those with a more central body profile tend to be weaker than others with the same weight. Individuals with low grip strength, as well as those with high ABSI, were more likely to die …

Yes, You Can Get A Job With That Major! Goal 5 Strategies For Facilitating, Assessing, And Demonstrating Psychology Students’ Professional Development, Kristin M. Vespia, Karen Z. Naufel, Jerry Rudmann, Jaye F. Van Kirk, Deborah Briihl, Jason Young

Publications and Research

The Summit on the National Assessment of Psychology was held on June 2016 to chart a path for assessing student achievement of the goals of the undergraduate psychology major. Our subcommittee was charged with identifying evaluation strategies and tools for students’ professional development, which included applying psychology to various careers; engaging in effective self-regulation, project management, and teamwork; and developing lifelong professional skills. In this article, therefore, we not only review a wide range of assessment tools for facilitating and evaluating professional development in psychology, but we also discuss the larger importance of the learning goal both to students and …

The Sensitivity Of Repeat And Near Repeat Analysis To Geocoding Algorithms, Cory P. Haberman, David Hatten, Jeremy G. Carter, Eric L. Piza

Publications and Research

Purpose: To determine if repeat and near repeat analysis is sensitive to the geocoding algorithm used for the underlying crime incident data.

Methods: The Indianapolis Metropolitan Police Department provided 2016 crime incident data for five crime types: (1) shootings, (2) robberies, (3) residential burglaries, (4) theft of automobiles, and (5) theft from automobiles. The incident data were geocoded using a dual ranges algorithm and a composite algorithm. First, descriptive analysis of the distances between the two point patterns were conducted. Second, repeat and near repeat analysis was performed. Third, the resulting repeat and near repeat patterns were compared across geocoding …

How Should We Understand The Digital Economy In Asia? Critical Assessment And Research Agenda, Kai Li, Dan J. Kim, Karl R. Lang, Robert J. Kauffman, Maurizio Naldi

Publications and Research

By Asian digital economy, we refer to high-tech developments, business and social transformations, and information- driven changes in the region’s growth. We discuss its background and foundations, significance in Asia and contribution to removal of historical barriers in traditional business. We assess how new value chains are transforming country-level involvement in worldwide manufacturing and note “smiling curve theory” predictions about the global value chain in Asia for high-tech firms and their economies. The takeaway is that the digital economy in Asian nations involves revamping business processes through technology innovation, government policies for growth, and digital entrepreneurship. We analyze the “digital …

Legislation, Linguistics, And Location: Exploring Attitudes On Unauthorized Immigration, David A. Caicedo, Vivienne Badaan

Publications and Research

Contemporary discourse on domestic immigration policy varies widely based on political affiliation, linguistics, and regional differences. This experimental study aimed to concurrently investigate three social psychological bases of attitudes towards unauthorized immigrants in the United States: political ideology, social labels, and social context. Participants were 744 adults, recruited from “New York Community College” (“NYCC”/urban) and “New Jersey Community College” (“NJCC”/suburban), who were randomly assigned to one of two experimental conditions: “illegal” vs. “undocumented”. Participants completed a scale measuring their attitudes towards unauthorized immigrants with the embedded label manipulation, followed by the General System Justification scale, and culminating with demographic items. …

Adapting To Remote Services: Getting Started With A Knowledge Base For Your Users, Sonali Sugrim

Publications and Research

This disruption to usual services as a result of the COVID-19 pandemic forced many librarians to reevaluate the methods with which their users connect with library personnel and library resources. The library is a vital source of information and during these times, it becomes our duty to ensure students and faculty are able to access resources, get research and instructional assistance and be able to continue to do their work with as little disruption as possible. The first step to this would be for the library to organize its contact information, resources and helpful links in one central location, in …

Improving Dental Hygiene Students' Journal Writing, Susan Davide

Publications and Research

During the introductory semester of treating patients, students are in need of assistance and guidance throughout the assessment and treatment phases of patient care. As novice learners, there is little to no prior knowledge on writing a patient case study presentation. To assist and improve dental hygiene student writing of patient case journals, a scaffold assignment was created. Over the course of the semester students were required to submit five patient case studies in the form of a journal. Each journal had a writing focus with specific directions for each along with a detailed rubric; the final journal encompassing all …

Resummation Of Non-Global Logarithms In Cross Sections With Massive Particles, Marcel Balsiger, Thomas Becher, Andrea Ferroglia

Publications and Research

A factorization formalism for jet processes involving massive colored particles such as the top quark is developed, extending earlier results for the massless case. The factorization of soft emissions from the underlying hard process is implemented in an effec tive field theory framework, which forms the basis for the resummation of large logarithms. The renormalization group evolution giving rise to non-global logarithms is implemented into a parton shower code in the large-Nc limit. After a comparison of the massive and massless radiation patterns, the cross section for t¯ t production with a veto on additional central jet activity is computed, …

State And Trait Rumination Effects On Overt Attention To Reminders Of Errors In A Challenging General Knowledge Retrieval Task, Ronald C. Whiteman, Jennifer A. Mangels

Publications and Research

Rumination is a recurrent and repetitive manner of thinking that can be triggered by blockage of personally relevant goals, creating a temporary state of abstract and evaluative self-focus. Particularly when focused on passive “brooding” over one’s problems and feelings, however, rumination can increase negative affect, interfere with problem-solving, and, through a negative feedback cycle, become a chronic trait-like style of responding to personal challenges, particularly in women. Given the pervasiveness of rumination and its potential impact on cognitive processes and emotional states, the present study asks how it impacts attention to feedback that either reminds individuals of goal-state discrepancies (reminders …

Ny Food 20/20: Vision, Research, And Recommendations During Covid-19 And Beyond, The Hunter College Nyc Food Policy Center, The Laurie M. Tisch Center For Food, Education & Policy, The Cuny Urban Food Policy Institute

Publications and Research

The public health and economic implications of the COVID-19 pandemic to the New York City (NYC) food system have been tremendous. In the six months since March 2020, when the pandemic reached NYC’s 5 boroughs, the number of food-insecure individuals has nearly doubled from 1.2 million to 2 million;1 diet quality for many individuals has decreased;2 the local food workforce has lost more than two-thirds of its workers;3 and more than 1,000 NYC restaurants and food retail outlets have closed,4 some never to re-open.

Too often the impacts of a crisis such as COVID-19 are not measured until long after …

The Quest For Greener Pastures: Evaluating The Livelihoods Impacts Of Providing Vegetation Condition Maps To Pastoralists In Eastern Africa, Elia Machado, Helene Purcell, Andrew M. Simons, Stephanie Swinehart

Publications and Research

The survival of millions of pastoral households in Eastern Africa has become increasingly at risk. Due to mounting socioeconomic and climatic stressors, pastoral households are faced with making migration decisions under increasing uncertainty about resource availability and limited coping strategies. We assess the potential of providing vegetation condition maps to support the migration decision of pastoralists in Ethiopia and Tanzania and the effect of map usage on their herd condition and size. The maps were generated from remotely sensed data using the Normalized Difference Vegetation Index (NDVI) as a proxy for vegetation condition and overlain with pastoralists’ preferred grazing areas. …

Sharing And Organizing Research Products As R Packages, Matti Vuorre, Matthew J. C. Crump

Publications and Research

A consensus on the importance of open data and reproducible code is emerging. How should data and code be shared to maximize the key desiderata of reproducibility, permanence, and accessibility? Research assets should be stored persistently in formats that are not software restrictive, and documented so that others can reproduce and extend the required computations. The sharing method should be easy to adopt by already busy researchers. We suggest the R package standard as a solution for creating, curating, and communicating research assets. The R package standard, with extensions discussed herein, provides a format for assets and metadata that satisfies …

More Austerity Coming? Lessons From New York City's 1970s Fiscal Crisis, Marc Kagan

Publications and Research

Crises can be moments of opportunity, but it is not foreordained who will seize the ring. The Great Depression ultimately led to the New Deal/Great Society state and increasing equality. 1975 New York City fiscal crisis, on the other hand, laid the groundwork for decades of neoliberal austerity. Despite political vulnerabilities, bankers and their Washington allies acted boldly to protect imperiled assets and remake a city in which the working class wielded some power as a bastion of finance capital. Seemingly powerful unions abandoned the public they served, and followed a risk-averse strategy of concessions in exchange for junior-partner corporatism, …

Life Expectancy And Active Life Expectancy By Disability Status In Older U.S. Adults, Haomiao Jia, Erica I. Lubetkin

Publications and Research

Objectives

The Medicare Health Outcome Survey (HOS) is the largest longitudinal survey of the U.S. community-dwelling elderly population. This study estimated total life expectancy, active life expectancy (ALE), and disability-free life expectancy (DFLE) by disability status among HOS participants.

Methods

Data were from the Medicare HOS Cohort 15 (baseline 2012, follow-up 2014). We included respondents aged ≥ 65 years (n = 164,597). Participants’ disability status was assessed based on the following six activities of daily living (ADL): bathing, dressing, eating, getting in or out of chairs, walking, and using the toilet. The multi-state models were used to estimate life expectancy, …

Amygdala–Prefrontal Connectivity Modulates Loss Aversion Bias In Anxious Individuals, Pengfei Xu, Nicholas T. Van Dam, Marie-José Van Tol, Xueyi Shen, Zaixu Cui, Ruolei Gu, Shaozheng Qin, André Aleman, Jin Fan, Yue-Jia Luo

Publications and Research

Anxious individuals tend to make pessimistic judgments in decision making under uncertainty. While this phenomenon is commonly attributed to risk aversion, loss aversion is a critical but often overlooked factor. In this study, we simultaneously examined risk aversion and loss aversion during decision making in high and low trait anxious individuals in a variable gain/loss gambling task during functional magnetic resonance imaging. Although high relative to low anxious individuals showed significant increased risk aversive behavior reflected by decreased overall gamble decisions, there was no group difference in subjective aversion to risk. Instead, loss aversion rather than risk aversion dominantly contributed …

You've Been With The Professors: An Examination Of Higher Education Work Stoppage Data: Past And Present, William A. Herbert, Jacob Apkarian

Publications and Research

This law review article analyzes work stoppage data in calendar years 2012-2018 involving academic and non-academic employees at higher education institutions. It contextualizes the recent data through a review of the history of unionization and strikes in the field of education along with faculty strike data for the period 1966-1994. The study contributes to the literature concerning unionization and collective bargaining in higher education and will be of value to those who study or are engaged in labor relations at colleges and universities. We find that there was a total of 42 strikes and one lock-out involving faculty, graduate assistants, …

Memory Bias Toward Emotional Information In Burnout And Depression, Renzo Bianchi, Eric Laurent, Irvin Sam Schonfeld, Lucas M. Bietti, Eric Mayor

Publications and Research

A sample of 1015 educational staff members, exhibiting various levels of burnout and depressive symptoms, underwent a memory test involving incident encoding of positive and negative words and a free recall task. Burnout and depression were each found to be associated with increased recall of negative items and decreased recall of positive items. Results remained statistically significant when controlling for history of depressive disorders. Burnout and depression were not related to mistakes in the reported words, or to the overall number of recalled words. This study suggests that burnout and depression overlap in terms of memory biases toward emotional information.

Resistance Exercise Intensity Does Not Influence Neurotrophic Factors Response In Equated Volume Schemes, Leandro Lodo, Alexandre Moreira, Reury Frank P Bacurau, Carol D. Capitani, Wesley P. Barbosa, Marcelo Massa, Brad J. Schoenfeld, Marcelo S. Aoki

Publications and Research

The aim of the present study was to evaluate the effects of 2 different intensities of resistance training (RT) bouts, performed with the equated total load lifted (TLL), on the acute responses of neurotrophic factors (NFs) (brain-derived neurotrophic factor [BDNF]; and nerve growth factor [NGF]), as well as on metabolic (lactate concentration) and hormonal (salivary cortisol concentration) responses. Thirty participants (males, 22.8 ± 2.3 years old, 177 ± 6.8 cm, 75.5 ± 7.9 kg, n = 15; and females, 22.2 ± 1.7 years, 163.7 ± 6.5 cm, 57 ± 7.6 kg, n = 15) performed 2 separate acute RT bouts …

Bringing Bilingualism To The Center Of Guided Reading Instruction, Laura Ascenzi-Moreno, Rebecca Quiñones

Publications and Research

Educators consider guided reading one of the most powerful instructional tools in a reading teacher’s arsenal. Yet, when it comes to emergent bilinguals in both monolingual English and bilingual settings, guided reading is implemented monolingually, or in one language at a time. As the field of reading instruction has moved toward a more asset‐based take on students’ bilingualism, integrating a bilingual approach to guided reading is necessary. The authors offer educators a lens to understand how emergent bilinguals’ resources and bilingualism can be incorporated into guided reading, along with concrete examples that can assist teachers in enacting these practices in …

Rectus Femoris Hyperreflexia Contributes To Stiff-Knee Gait After Stroke, Tunc Akbas, Kyoungsoon Kim, Kathleen Doyle, Kathleen Manella, Robert Lee, Patrick Spicer, Maria Knikou, James Sulzer

Publications and Research

Background: Stiff-Knee gait (SKG) after stroke is often accompanied by decreased knee flexion angle during the swing phase. The decreased knee flexion has been hypothesized to originate from excessive quadriceps activation.However, it is unclear whether hyperreflexia plays a role in this activation. The goal of this study was to establish the relationship between quadriceps hyperreflexia and knee flexion angle during walking in post-stroke SKG.

Methods: The rectus femoris (RF) H-reflex was recorded in 10 participants with post-stroke SKG and 10 healthy controls during standing and walking at the pre-swing phase. In order to attribute the pathological neuromodulation to quadriceps muscle …

Ionophoric Polyphenols Are Permeable To The Blood Brain Barrier, Interact With Human Serum Albumin And Calf Thymus Dna, And Inhibit Ache Enzymatic Activity, Alberto Martinez, Mai Zahran, Miguel Gomez, Johnny Guevara, Rosemary Pichardo-Bueno, Junaid Asim, Gabriel Ortiz, Yaa Andoh, Sinji Shibutani, Baljit Kaur

Publications and Research

Alzheimer’s disease (AD) is the most common form of dementia that affects more than 40 million people around the world. The incidence is expected to rapidly increase due to the lack of any effective treatment. In previous work we synthesized a family of five ionophoric polyphenols (compounds 1–5) that targeted important aspects related to AD, such as the toxic aggregation of amyloid-β peptides, the production of reactive oxygen species, or the excessive presence of Cu²⁺ ions. Here, in order to gain insights into their potential therapeutic value, we have tested the ability of compounds 1– …

Stock Market Transmission Channel Of Monetary Policy: Empirical Evidence From Turkey, Ilhami Gunduz

Publications and Research

Monetary policy is one of the instruments that policymakers use to provide both sustainable economic growth and price stability. In this study, I analyze the stock market transmission channel of the monetary policy of the Turkish economy not only at the aggregate but also at the sectoral level in a structural vector autoregression (SVAR) framework. I adopt alternative variables as a policy instrument. When the spread is used as a policy instrument, I find that contractionary monetary policy has a significant negative effect on both output and the price level, and it appreciates the Turkish Lira. Besides, the tight monetary …

Involuntary Treatment In Dementia Care At Home: Results From The Netherlands And Belgium, Angela M. H. J. Mengelers, Vincent R. A. Moermans, Michel H. C. Bleijlevens, Hilde Verbeek, Elizabeth Capezuti, Frans Tan, Koen Milisen, Jan P. H. Hamers

Publications and Research

Aims and objectives: To gain insight into the request, use and associated factors of involuntary treatment in people with dementia (PwD) receiving professional home care in the Netherlands and Belgium.

Background: Most of the PwD remain living at home as long as possible. Due to complex care needs, this can result in an increased risk for care provided against the wishes of the client and/or to which the client resists, referred to as involuntary treatment.

Design: Secondary data analyses of two cross-sectional surveys.

Methods: Dementia case managers and district nurses filled in a questionnaire for each PwD in their …

Ptsd And Depressive Symptoms As Potential Mediators Of The Association Between World Trade Center Exposure And Subjective Cognitive Concerns In Rescue/Recovery Workers, Ankura Singh, Rachel Zeig-Owens, Laura Rabin, Theresa Schwartz, Mayris P. Webber, David Appel, David J. Prezant, Charles B. Hall

Publications and Research

We observed that World Trade Center (WTC) exposure, post-traumatic stress disorder (PTSD) symptoms and depressive symptoms were associated with subjective cognitive concerns in Fire Department of the City of New York (FDNY) rescue/recovery workers. This follow-up study examined whether PTSD symptoms and/or depressive symptoms mediate the observed association between WTC exposure and subjective cognitive concerns. We included WTC-exposed FDNY workers who completed the Cognitive Function Instrument (CFI), measuring self-perceived cognitive decline (N = 9516). PTSD symptoms and depressive symptoms were assessed using the PCL-S and CES-D, respectively. Multivariable linear regression estimated the association between WTC exposure and CFI score, adjusting …

A Study Of The Relationship Between Uric Acid And Substantia Nigra Brain Connectivity In Patients With Rem Sleep Behavior Disorder And Parkinson’S Disease, Timothy M. Ellmore, Jessika Suescun, Richard J. Castriotta, Mya C. Schiess

Publications and Research

Low levels of the natural antioxidant uric acid (UA) and the presence of REM sleep behavior disorder (RBD) are both associated with an increased likelihood of developing Parkinson’s disease (PD). RBD and PD are also accompanied by basal ganglia dysfunction including decreased nigrostriatal and nigrocortical resting state functional connectivity. Despite these independent findings, the relationship between UA and substantia nigra (SN) functional connectivity remains unknown. In the present study, voxelwise analysis of covariance was used in a cross-sectional design to explore the relationship between UA and whole-brain SN functional connectivity using the eyes-open resting state fMRI method in controls without …

Leaving A Covenantal Religion: Orthodox Jewish Disaffiliation From An Immigration Psychology Perspective, Joel Engelman, Glen Milstein, Irvin Sam Schonfeld, Joshua B. Grubbs

Publications and Research

This study explored psychological variables associated with disaffiliation from Orthodox Judaism (a covenantal community), and subsequent wellness. A web-based survey (N = 206) assessed factors previously used to study immigrants: push (distress within origin community), pull (toward destination community), and goal attainment. Psychological wellness, perceived stress, overall health, and loneliness were also assessed. Findings included: (1) strong pull toward opportunities for physical and ideological autonomy; (2) those who experienced more push toward disaffiliation, reported decreased current wellness; (3) goal attainment was associated with increased wellbeing; (4) significant differences in the experiences of disaffiliation between men and women; (5) most who …

Moral Dilemma Of A Physician And Mother In The Midst Of The Covid-19 Pandemic, Sarah Rosanel, Joshua Fogel

Publications and Research

No abstract provided.

Applied Strategies For Remote Student Teaching Due To Covid-19, Natalie G. Chertoff, Ashleigh B. Thompson

Publications and Research

City University of New York's pre-service teachers in clinical coursework (fieldwork and student teaching) during AY20-21 will face new and emerging challenges. Developing relationships with cooperating teachers, students and families, some of whom may have experienced significant trauma during the pandemic; teaching content remotely; utilizing new technologies — these are just some examples of the topics included in this brief. Sections are intended for pre-service teacher candidates, clinical supervisors, principals and cooperating teachers. Many resources include links to citations so that readers can explore them in greater depth as they think through planning, enacting and assessing remote learning, whether it’s …

Epigenetic Targeting Of Mcl-1 Is Synthetically Lethal With Bcl-Xl/Bcl-2 Inhibition In Model Systems Of Glioblastoma, Enyuan Shang, Trang T. T. Nguyen, Chang Shu, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Publications and Research

Apoptotic resistance remains a hallmark of glioblastoma (GBM), the most common primary brain tumor in adults, and a better understanding of this process may result in more efficient treatments. By utilizing chromatin immunoprecipitation with next-generation sequencing (CHIP-seq), we discovered that GBMs harbor a super enhancer around the Mcl-1 locus, a gene that has been known to confer cell death resistance in GBM.We utilized THZ1, a known super-enhancer blocker, and BH3-mimetics, including ABT263, WEHI-539, and ABT199. Combined treatment with BH3-mimetics and THZ1 led to synergistic growth reduction in GBM models. Reduction in cellular viability was accompanied by significant cell death induction …