Digital Commons Network^™

Pkmζ Differentially Utilized Between Sexes For Remote Long-Term Spatial Memory, Veronica Sebastian, Tatyana Vergel, Raheela Baig, Lisa M. Schrott, Peter A. Serrano

Publications and Research

It is well established that male rats have an advantage in acquiring place-learning strategies, allowing them to learn spatial tasks more readily than female rats. However many of these differences have been examined solely during acquisition or in 24h memory retention. Here, we investigated whether sex differences exist in remote long-term memory, lasting 30d after training, and whether there are differences in the expression pattern of molecular markers associated with long-term memory maintenance. Specifically, we analyzed the expression of protein kinase M zeta (PKMζ) and the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA2. To adequately evaluate memory retention, we used a …

Communication And Common Interest, Peter Godfrey-Smith, Manolo Martínez

Publications and Research

Explaining the maintenance of communicative behavior in the face of incentives to deceive, conceal information, or exaggerate is an important problem in behavioral biology. When the interests of agents diverge, some form of signal cost is often seen as essential to maintaining honesty. Here, novel computational methods are used to investigate the role of common interest between the sender and receiver of messages in maintaining cost-free informative signaling in a signaling game. Two measures of common interest are defined. These quantify the divergence between sender and receiver in their preference orderings over acts the receiver might perform in each state …

Diversified Microbiota Of Meconium Is Affected By Maternal Diabetes Status, Jianzhong Hu, Yoko Nomura, Ali Bashir, Heriberto Fernandez-Hernandez, Steven Itzkowitz, Zhiheng Pei, Joanne Stone, Holly Loudon, Inga Peter

Publications and Research

Objectives This study was aimed to assess the diversity of the meconium microbiome and determine if the bacterial community is affected by maternal diabetes status. Methods The first intestinal discharge (meconium) was collected from 23 newborns stratified by maternal diabetes status: 4 mothers had pre-gestational type 2 diabetes mellitus (DM) including one mother with dizygotic twins, 5 developed gestational diabetes mellitus (GDM) and 13 had no diabetes. The meconium microbiome was profiled using multi-barcode 16S rRNA sequencing followed by taxonomic assignment and diversity analysis. Results All meconium samples were not sterile and contained diversified microbiota. Compared with adult feces, the …

Insight, Neurocognition, And Schizophrenia: Predictive Value Of The Wisconsin Card Sorting Test, John Stratton, Philip T. Yanos, Paul Lysaker

Publications and Research

Lack of insight in schizophrenia is a key feature of the illness and is associated with both positive and negative clinical outcomes. Previous research supports that neurocognitive dysfunction is related to lack of insight, but studies have not examined how neurocognition relates to change in insight over time. Therefore, the current study sought to understand how performance on the Wisconsin Card Sorting Test (WCST) differed between participants with varying degrees of change in insight over a 6-month period. Fifty-two patients with schizophrenia or schizoaffective disorder were administered the WCST and Positive and Negative Syndrome Scale (PANSS) at baseline, and the …

Dental Hygienists' Knowledge Of Hiv, Attitudes Towards People With Hiv And Willingness To Conduct Rapid Hiv Testing, Anthony J. Santella, B Krishnamachari, Susan H. Davide, Marilyn Cortell, Winnie Furnari, B Watts, Sarah C. Hayden

Publications and Research

This study was aimed to determine the dental hygienists' knowledge of HIV, attitudes towards people living with HIV and willingness to conduct rapid HIV testing.

Can Enlightenment Be Traced To Specific Neural Correlates, Cognition, Or Behavior? No, And (A Qualified) Yes, Jake H. Davis, David R. Vago

Publications and Research

The field of contemplative science is rapidly growing and integrating into the basic neurosciences, psychology, clinical sciences, and society-at-large. Yet the majority of current research in the contemplative sciences has been divorced from the soteriological context from which these meditative practices originate and has focused instead on clinical applications with goals of stress reduction and psychotherapeutic health. In the existing research on health outcomes of mindfulness-based clinical interventions, for example, there have been almost no attempts to scientifically investigate the goal of enlightenment. This is a serious oversight, given that such profound transformation across ethical, perceptual, emotional, and cognitive domains …

Factors Associated With Smoking Among Adolescent Males Prior To Incarceration And After Release From Jail: A Longitudinal Study, Megha Ramaswamy, Babalola Faseru, Karen L. Cropsey, Marvia Jones, Karisa Deculus, Nicholas Freudenberg

Publications and Research

Background The prevalence of cigarette smoking among incarcerated adult men and women is three-four times higher than in the general population, ranging from 70-80%. However, little is known about factors associated with smoking among incarcerated adolescents, especially upon their re-entry into communities after release from jail. The current study explores factors associated with smoking among adolescent males prior to incarceration and one year after their release from jail. Methods We conducted a secondary data analysis of the Returning Educated African-American and Latino Men to Enriched Neighborhoods (REAL MEN) study, which was designed to reduce HIV risk, substance use, and recidivism …

Cardiovascular Disease Hospitalizations In Relation To Exposure To The September 11, 2001 World Trade Center Disaster And Posttraumatic Stress Disorder, Hannah T. Jordan, Steven D. Stellman, Alfredo Morabia, Sara A. Miller‐Archie, Howard Alper, Zoey Laskaris, Robert M. Brackbill, James E. Cone

Publications and Research

Background A cohort study found that 9/11‐related environmental exposures and posttraumatic stress disorder increased self‐reported cardiovascular disease risk. We attempted to replicate these findings using objectively defined cardiovascular disease hospitalizations in the same cohort. Methods and Results Data for adult World Trade Center Health Registry enrollees residing in New York State on enrollment and no cardiovascular disease history (n=46 346) were linked to a New York State hospital discharge–reporting system. Follow‐up began at Registry enrollment (2003–2004) and ended at the first cerebrovascular or heart disease (HD) hospitalization, death, or December 31, 2010, whichever was earliest. We used proportional hazards models …

Acute Physiological Stress Promotes Clustering Of Synaptic Markers And Alters Spine Morphology In The Hippocampus, Veronica Sebastian, Jim Brian Estil, Daniel Chen, Lisa M. Schrott, Peter A. Serrano

Publications and Research

GluA2-containing AMPA receptors and their association with protein kinase M zeta (PKMζ) and post-synaptic density-95 (PSD-95) are important for learning, memory and synaptic plasticity processes. Here we investigated these synaptic markers in the context of an acute 1h platform stress, which can disrupt spatial memory retrieval for a short-term memory on the object placement task and long-term memory retrieval on a well-learned radial arm maze task. Acute stress increased serum corticosterone and elevated the expression of synaptic PKMζ while decreasing synaptic GluA2. Using co-immunoprecipitation, we found that this stressor promotes the clustering of GluA2, PKMζ and PSD-95, which is consistent …

Ethical Issues In Knowledge Management: Conflict Of Knowledge Ownership, Isabel D. W. Rechberg, Jawad Syed

Publications and Research

Purpose: This paper reviews ethical issues inherent in the theorisation and practice of knowledge management (KM) with specific attention to the conflict of knowledge ownership between organisations and individual employees.

Design/methodology/approach: Relevant literature was identified and reviewed via EBSCO host and ISIWeb.

Findings: The paper notes that knowledge, although rooted in individuals, is often claimed or treated as owned by organisations, creating a conflict of knowledge ownership. The paper argues that such an approach to appropriation and management of knowledge leads to tension in knowledge processes between organisations and individuals, and also among individuals. This situation may, in turn, jeopardise …

Anxiety And Error Monitoring: The Importance Of Motivation And Emotion, Greg H. Proudfit, Michael Inzlicht, Douglas S. Mennin

Publications and Research

No abstract provided.

The Queer Dialectic Of Whitman’S Nation: "Let" In “Respondez”, Václav Paris

Publications and Research

This article considers Whitman's "Respondez" - perhaps his strangest poem. It seeks to explicate the poem by looking at his shifting use of the word "let." The article draws on studies of queer theory, nationalism, modernism, to reveal an unfamiliar and far more radical Whitman than we are familiar with.

Intimate Partner Violence During Pregnancy: Victim Or Perpetrator? Does It Make A Difference?, Yuliya Shneyderman, Michele Kiely

Publications and Research

Objectives: To differentiate between forms of intimate partner violence (IPV)(victim only, perpetrator only, or participating in reciprocal violence) and examine risk profiles and pregnancy outcomes.

Design: Prospective

Setting: Washington, DC, July 2001 to October 2003

Sample: 1044 high-risk African-American pregnant women who participated in a randomized controlled trial to address IPV, depression, smoking, and environmental tobacco smoke exposure.

Methods: Multivariable linear and logistic regression

Main outcome measures: Low and very low birth weight, preterm and very preterm birth

Results: 5% of women were victims only, 12% were perpetrators only, 27% participated in reciprocal violence, and 55% reported no IPV. …

Sequential Screening For Psychosocial And Behavioural Risk During Pregnancy In A Population Of Urban African Americans, Michele Kiely, Marie G. Gantz, M. Nabil El-Khorazaty, Ayman El-Mohandes

Publications and Research

Objective: Screening for psychosocial and behavioral risks, such as depression, intimate partner violence and smoking, during pregnancy is considered state-of-the-art in prenatal care (PNC). This prospective longitudinal analysis examines the added benefit of repeated screening over a one-time screen in identifying such risks during pregnancy.

Design: Data were collected as part of a randomized controlled trial to address intimate partner violence (IPV), depression, smoking and environmental tobacco smoke exposure (ETSE) in African-Americans women.

Setting: PNC sites in the District of Columbia serving mainly minority women

Population: 1044 African-American pregnant women in the District of Columbia

Methods: Mothers were classified by …

Fmri Of Working Memory Impairment After Recovery From Subarachnoid Hemorrhage, Timothy M. Ellmore, Fiona Rohlffs, Faraz Khursheed

Publications and Research

Recovery from aneurysmal subarachnoid hemorrhage (SAH) is often incomplete and accompanied by subtle but persistent cognitive deficits. Previous neuropsychological reports indicate these deficits include most prominently memory impairment, with working memory particularly affected. The neural basis of these memory deficits remains unknown and unexplored by functional magnetic resonance imaging (fMRI). In the present study, patients who experienced (SAH) underwent fMRI during the performance of a verbal working memory paradigm. Behavioral results indicated a subtle but statistically significant impairment relative to healthy subjects in working memory performance accuracy, which was accompanied by relatively increased blood-oxygen level dependent signal in widespread left …

Le Nature Degli American Studies, Cindi Katz

Publications and Research

Al “Futures of American Studies Institute” di Dartmouth del 2003 lanciai una provocazione sulle “geografie immaginate” dell’americanistica. Volevo mettere in discussione sia le celebrazioni romantiche del “luogo” in quanto elemento in qualche modo autentico e particolare, minacciato da un mondo sempre più globalizzato e controllato dalle multinazionali, sia l’esaltazione della “delocalizzazione” nelle società in rete, negli “spazi di flusso”, nella mobilità senza attrito. Suggerivo che queste, come altre geografie poco studiate, si sposano troppo facilmente con molte correnti dell’eccezionalismo americano.

Speaking As One: Supporting Open Access With Departmental Resolutions, Madeline Cohen, Maura A. Smale, Jill Cirasella, Cynthia Tobar, Jessie Daniels

Publications and Research

Library faculty at the City University of New York (CUNY) have engaged in promoting and advocating for open access publishing at each of our campuses as well as across the University. Inspired by the passing of a faculty senate resolution in support of the creation of an open access institutional repository and associated policies, many CUNY librarians felt the need to raise their level of commitment. In this article, the authors—four library faculty members and one faculty member from outside the library—share their experiences creating and approving open access policies in the library departments of four CUNY schools and promoting …

Synesthesia: A Colorful Word With A Touching Sound?, Myrto I. Mylopoulos, Tony Ro

Publications and Research

Synesthesia is a fairly common condition in which individuals experience atypical responses (such as color experiences) in association with certain types of stimuli (such as non-colored letters). Although synesthesia has been described for centuries, only very recently has there been an explosive growth of systematic scientific examinations of this condition. In this article, we review and critically evaluate current methods for both assessing synesthesia and examining its psychological basis, including the “test-retest” procedure, online battery assessments, and behavioral experiments. We highlight the limitations of these methods for understanding the nature of this complex condition and propose potential solutions to address …

It’S Time To Fear! Interval Timing In Odor Fear Conditioning In Rats, Kiseko Shionoya, Chloé Hegoburu, Bruce L. Brown, Regina M. Sullivan, Valérie Doyère, Anne-Marie Mouly

Publications and Research

Time perception is crucial to goal attainment in humans and other animals, and interval timing also guides fundamental animal behaviors. Accumulating evidence has made it clear that in associative learning, temporal relations between events are encoded, and a few studies suggest this temporal learning occurs very rapidly. Most of these studies, however, have used methodologies that do not permit investigating the emergence of this temporal learning. In the present study we monitored respiration, ultrasonic vocalization (USV) and freezing behavior in rats in order to perform fine-grain analysis of fear responses during odor fear conditioning. In this paradigm an initially neutral …

Modified Impact Of Emotion On Temporal Discrimination In A Transgenic Rat Model Of Huntington Disease, Alexis Faure, Mouna Es-Sesddiqi, Bruce L. Brown, Hoa P. Nguyen, Olaf Riess, Stephan Von Hörsten, Pascale Le Blanc, Nathalie Desvignes, Bruno Bozon, Nicole El Massioui, Valérie Doyère

Publications and Research

Huntington's disease (HD) is characterized by triad of motor, cognitive, and emotional symptoms along with neuropathology in fronto-striatal circuit and limbic system including amygdala. Emotional alterations, which have a negative impact on patient well-being, represent some of the earliest symptoms of HD and might be related to the onset of the neurodegenerative process. In the transgenic rat model (tgHD rats), evidence suggest emotional alterations at the symptomatic stage along with neuropathology of the central nucleus of amygdala (CE). Studies in humans and animals demonstrate that emotion can modulate time perception. The impact of emotion on time perception has never been …

From Tweet To Blog Post To Peer-Reviewed Article: How To Be A Scholar Now, Jessie Daniels

Publications and Research

Digital media is changing how scholars interact, collaborate, write and publish. This piece describes how to be a scholar now, when peer-reviewed articles can begin as Tweets and blog posts. In this new environment, scholars are able to create knowledge in ways that are more open, more fluid, and more easily read by wider audiences.

Assessing The Burden Of Crime And The Criminal Sanction: A Public Health Perspective On Critical Issues In Criminal Justice, Jeremy Travis

Publications and Research

No abstract provided.

Differential Joint-Specific Corticospinal Tract Projections Within The Cervical Enlargement, Curtis O. Asante, John H. Martin

Publications and Research

The motor cortex represents muscle and joint control and projects to spinal cord interneurons and–in many primates, including humans–motoneurons, via the corticospinal tract (CST). To examine these spinal CST anatomical mechanisms, we determined if motor cortex sites controlling individual forelimb joints project differentially to distinct cervical spinal cord territories, defined regionally and by the locations of putative last-order interneurons that were transneuronally labeled by intramuscular injection of pseudorabies virus. Motor cortex joint-specific sites were identified using intracorticalmicrostimulation. CST segmental termination fields from joint-specific sites, determined using anterograde tracers, comprised a high density core of terminations that was consistent between animals …

Cholinergic Enhancement Of Brain Activation In Mild Cognitive Impairment During Episodic Memory Encoding, Shannon L. Risacher, Yang Wang, Heather A. Wishart, Laura A. Rabin, Laura A. Flashman, Brenna C. Mcdonald, John D. West, Robert B. Santulli, Andrew J. Saykin

Publications and Research

Objective: To determine the physiological impact of treatment with donepezil (Aricept) on neural circuitry supporting episodic memory encoding in patients with amnestic mild cognitive impairment (MCI) using functional magnetic resonance imaging (fMRI).

Methods: Eighteen patients with MCI and 20 age-matched healthy controls (HC) were scanned twice while performing an event-related verbal episodic encoding task. MCI participants were scanned before treatment and after approximately 3 months on donepezil; HCwere untreated but rescanned at the same interval.Voxel-level analyses assessed treatment effects on activation profiles in MCI patients relative to retest changes in non-treated HC. Changes in task-related connectivity in medial temporal circuitry …

Students' Immersion Experiences In Study Abroad, Federica Goldoni

Publications and Research

Data show that a larger number of students than ever are participating in learning experiences abroad. However, such programs are not always as immersive and intensive as participants, faculty, program directors, and administrators would wish. This study examines the ways in which students created sustained opportunities to interact with members of the host community as well as episodes of cultural clash, miscommunication, and misunderstanding experienced at the intersection of two cultures that led to diminishing willingness to interact with members of the host community. The article concludes with recommendations for pre-departure experiences that are designed to help students become more …

The Enemy Within: Propagation Of Aberrant Corticostriatal Learning To Cortical Function In Parkinson’S Disease, Jeff A. Beeler, Giselle Petzinger, Michael W. Jakowec

Publications and Research

Motor dysfunction in Parkinson’s disease is believed to arise primarily from pathophysiology in the dorsal striatum and its related corticostriatal and thalamostriatal circuits during progressive dopamine denervation. One function of these circuits is to provide a filter that selectively facilitates or inhibits cortical activity to optimize cortical processing, making motor responses rapid and efficient. Corticostriatal synaptic plasticity mediates the learning that underlies this performance-optimizing filter. Under dopamine denervation, corticostriatal plasticity is altered, resulting in aberrant learning that induces inappropriate basal ganglia filtering that impedes rather than optimizes cortical processing. Human imaging suggests that increased cortical activity may compensate for striatal …

Fashion Vs. Function In Cultural Evolution: The Case Of Dog Breed Popularity, Stefano Ghirlanda, Alberto Acerbi, Harold Herzog, James A. Serpell

Publications and Research

We investigate the relationship between characteristics of dog breeds and their popularity between years 1926 and 2005. We consider breed health, longevity, and behavioral qualities such as aggressiveness, trainability, and fearfulness. We show that a breed's overall popularity, fluctuations in popularity, and rates of increase and decrease around popularity peaks show typically no correlation with these breed characteristics. One exception is the finding that more popular breeds tend to suffer from more inherited disorders. Our results support the hypothesis that dog breed popularity has been primarily determined by fashion rather than function.

Unconscious Priming Requires Early Visual Cortex At Specific Temporal Phases Of Processing, Marjan Persuh, Tony Ro

Publications and Research

Although examples of unconscious shape priming have been well documented, whether such priming requires early visual cortex (V1/V2) has not been established. In the current study, we used TMS of V1/V2 at varying temporal intervals to suppress the visibility of preceding shape primes while the interval between primes and targets was kept constant. Our results show that, although conscious perception requires V1/V2, unconscious priming can occur without V1/V2 at an intermediate temporal interval but not at early (5–25 msec) or later (65–125 msec) stages of processing. Because the later time window of unconscious priming suppression has been proposed to interfere …

Toward A Broader Dialectic: Joining Marxism With Mailer To Forge A Multilectics That Advances Teaching And Learning, Gene Fellner

Publications and Research

I contrast the lenses that Norman Mailer, Herbert Marcuse, and Karl Marx bring to their analyses of social life, exploring the contributions and limits of their respective approaches. I then propose what I call a “multilectical” theoretical lens that encompasses the strengths of all three and leans on the insights of post-Marxist theorists. The multilectical lens is then applied to an event that transpired in a severely underperforming middle school.

Mood And The Market: Can Press Reports Of Investors’ Mood Predict Stock Prices?, Yochi Cohen-Charash, Charles A. Scherbaum, John D. Kammeyer-Muller, Barry M. Staw

Publications and Research

We examined whether press reports on the collective mood of investors can predict changes in stock prices. We collected data on the use of emotion words in newspaper reports on traders’ affect, coded these emotion words according to their location on an affective circumplex in terms of pleasantness and activation level, and created indices of collective mood for each trading day. Then, by using time series analyses, we examined whether these mood indices, depicting investors’ emotion on a given trading day, could predict the next day’s opening price of the stock market. The strongest findings showed that activated pleasant mood …