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Full-Text Articles in Entire DC Network
Early Invasion Of Brain Parenchyma By African Trypanosomes, Ute Frevert, Alexandru Movila, Olga V. Nikolskaia, Jayne Raper, Zachary B. Mackey, Maha Abdulla, James Mckerrow, Dennis J. Grab
Early Invasion Of Brain Parenchyma By African Trypanosomes, Ute Frevert, Alexandru Movila, Olga V. Nikolskaia, Jayne Raper, Zachary B. Mackey, Maha Abdulla, James Mckerrow, Dennis J. Grab
Publications and Research
Human African trypanosomiasis or sleeping sickness is a vector-borne parasitic disease that has a major impact on human health and welfare in sub-Saharan countries. Based mostly on data from animal models, it is currently thought that trypanosome entry into the brain occurs by initial infection of the choroid plexus and the circumventricular organs followed days to weeks later by entry into the brain parenchyma. However, Trypanosoma brucei bloodstream forms rapidly cross human brain microvascular endothelial cells in vitro and appear to be able to enter the murine brain without inflicting cerebral injury. Using a murine model and intravital brain imaging, …
The Structural Stability Of The Endothelial Glycocalyx After Enzymatic Removal Of Glycosaminoglycans, Ye Zeng, Eno E. Ebong, Bingmei M. Fu, John M. Tarbell
The Structural Stability Of The Endothelial Glycocalyx After Enzymatic Removal Of Glycosaminoglycans, Ye Zeng, Eno E. Ebong, Bingmei M. Fu, John M. Tarbell
Publications and Research
Rationale It is widely believed that glycosaminoglycans (GAGs) and bound plasma proteins form an interconnected gel-like structure on the surface of endothelial cells (the endothelial glycocalyx layer–EGL) that is stabilized by the interaction of its components. However, the structural organization of GAGs and proteins and the contribution of individual components to the stability of the EGL are largely unknown. Objective To evaluate the hypothesis that the interconnected gel-like glycocalyx would collapse when individual GAG components were almost completely removed by a specific enzyme. Methods and Results Using confocal microscopy, we observed that the coverage and thickness of heparan sulfate (HS), …
Γ-Synuclein Interacts With Phospholipase Cβ2 To Modulate G Protein Activation, Urszula Golebiewska, Yuanjian Guo, Narindra Khalikaprasad, Cassandra Zurawsky, V. Siddhartha Yerramilli, Suzanne Scarlata
Γ-Synuclein Interacts With Phospholipase Cβ2 To Modulate G Protein Activation, Urszula Golebiewska, Yuanjian Guo, Narindra Khalikaprasad, Cassandra Zurawsky, V. Siddhartha Yerramilli, Suzanne Scarlata
Publications and Research
Phospholipase Cβ2 (PLC β2) is activated by G proteins and generates calcium signals in cells. PLCβ2 is absent in normal breast tissue, but is highly expressed in breast tumors where its expression is correlated with the progression and migration of the tumor. This pattern of expression parallels the expression of the breast cancer specific gene protein 1 which is also known as γ-synuclein. The cellular function of γ-synuclein and the role it plays in proliferation are unknown. Here, we determined whether γ-synuclein can interact with PLCβ2 and affect its activity. Using co-immunprecitation and co-immunofluorescence, we find that in both benign …
Weaponizing Tear Gas: Bahrain’S Unprecedented Use Of Toxic Chemical Agents Against Civilians., Richard Sollom, Holly G. Atkinson
Weaponizing Tear Gas: Bahrain’S Unprecedented Use Of Toxic Chemical Agents Against Civilians., Richard Sollom, Holly G. Atkinson
Publications and Research
The Bahraini government’s response to the early 2011 pro-democracy protests was brutal, systematic, and violent. In addition to birdshot and rubber bullets, government law enforcement attacked unarmed protestors with toxic chemical agents including tear gas. The government’s crackdown on the medical profession was especially harmful, as security forces arrested and detained doctors, raided health facilities, and obstructed patients from receiving necessary care. This report’s findings are based on field research that the authors conducted in Bahrain (April 2012) to investigate excessive use of force by law enforcement officials since June 2011—the end of Bahrain’s state of emergency. The medico-legal team …
Loss Of A 20s Proteasome Activator In Saccharomyces Cerevisiae Downregulates Genes Important For Genomic Integrity, Increases Dna Damage, And Selectively Sensitizes Cells To Agents With Diverse Mechanisms Of Action, Kevin M. Doherty, Leah D. Pride, James Lukose, Brian E. Snydsman, Ronald Charles, Ajay Pramanik, Eric G. Muller, David Botstein, Carol Wood Moore
Loss Of A 20s Proteasome Activator In Saccharomyces Cerevisiae Downregulates Genes Important For Genomic Integrity, Increases Dna Damage, And Selectively Sensitizes Cells To Agents With Diverse Mechanisms Of Action, Kevin M. Doherty, Leah D. Pride, James Lukose, Brian E. Snydsman, Ronald Charles, Ajay Pramanik, Eric G. Muller, David Botstein, Carol Wood Moore
Publications and Research
Cytoprotective functions of a 20S proteasome activator were investigated. Saccharomyces cerevisiae Blm10 and human 20S proteasome activator 200 (PA200) are homologs. Comparative genome-wide analyses of untreated diploid cells lacking Blm10 and growing at steady state at defined growth rates revealed downregulation of numerous genes required for accurate chromosome structure, assembly and repair, and upregulation of a specific subset of genes encoding protein-folding chaperones. Blm10 loss or truncation of the Ubp3/Blm3 deubiquitinating enzyme caused massive chromosomal damage and cell death in homozygous diploids after phleomycin treatments, indicating that Blm10 and Ubp3/Blm3 function to stabilize the genome and protect against cell death. …
Halogen Activation Via Interactions With Environmental Ice And Snow In The Polar Lower Troposphere And Other Regions, J. P. D. Abbatt, J. L. Thomas, K. Abrahamsson, Chris Boxe, A. Granfors, A. E. Jones, M. D. King, A. Saiz-Lopez, P. B. Shepson, J. Sodeau, D. W. Toohey, C. Toubin, R. Von Glasow, S. N. Wren, X. Yang
Halogen Activation Via Interactions With Environmental Ice And Snow In The Polar Lower Troposphere And Other Regions, J. P. D. Abbatt, J. L. Thomas, K. Abrahamsson, Chris Boxe, A. Granfors, A. E. Jones, M. D. King, A. Saiz-Lopez, P. B. Shepson, J. Sodeau, D. W. Toohey, C. Toubin, R. Von Glasow, S. N. Wren, X. Yang
Publications and Research
The role of ice in the formation of chemically active halogens in the environment requires a full understanding because of its role in atmospheric chemistry, including controlling the regional atmospheric oxidizing capacity in specific situations. In particular, ice and snow are important for facilitating multiphase oxidative chemistry and as media upon which marine algae live. This paper reviews the nature of environmental ice substrates that participate in halogen chemistry, describes the reactions that occur on such substrates, presents the field evidence for ice-mediated halogen activation, summarizes our best understanding of ice-halogen activation mechanisms, and describes the current state of modeling …
Comparing Unique Title Coverage Of Web Of Science And Scopus In Earth And Atmospheric Sciences, Philip Barnett, Claudia Lascar
Comparing Unique Title Coverage Of Web Of Science And Scopus In Earth And Atmospheric Sciences, Philip Barnett, Claudia Lascar
Publications and Research
No abstract provided.
Occupy Mindfulness, David Forbes
Professor Sheidlower's New Book, John A. Drobnicki
Professor Sheidlower's New Book, John A. Drobnicki
Publications and Research
The book Humor and Information Literacy was co-authored by Scott Sheidlower and Joshua Vossler.
Negrocity: An Interview With Greg Tate, Camille Goodison
Negrocity: An Interview With Greg Tate, Camille Goodison
Publications and Research
No abstract provided.
Racial Microaggressions And The Filipino American Experience: Recommendations For Counseling And Development, Kevin L. Nadal, Kara M. Vigilia Escobar, Gail T. Prado, Ejr David, Kristal Haynes
Racial Microaggressions And The Filipino American Experience: Recommendations For Counseling And Development, Kevin L. Nadal, Kara M. Vigilia Escobar, Gail T. Prado, Ejr David, Kristal Haynes
Publications and Research
Racial microaggressions are subtle forms of verbal and behavioral discrimination toward people of color. The current qualitative study explores the experiences of Filipino American participants (N = 12), who described 13 categories of microaggressions, including being treated as an alien in one’s own land or as a 2nd-class citizen, being presumed to have inferior status or intellect, being assumed to uphold Filipino stereotypes, or being mistaken for another identity. Recommendations for counseling and development are discussed.
Exploring The Role Of The Police In Prisoner Reentry, Jeremy Travis, Ronald Davis, Sarah Lawrence
Exploring The Role Of The Police In Prisoner Reentry, Jeremy Travis, Ronald Davis, Sarah Lawrence
Publications and Research
No abstract provided.
Pioneers Of Youth Justice Reform: Achieving System Change Using Resolution, Reinvestment, And Realignment Strategies, Douglas N. Evans
Pioneers Of Youth Justice Reform: Achieving System Change Using Resolution, Reinvestment, And Realignment Strategies, Douglas N. Evans
Publications and Research
In the past three decades, state and local governments implemented various reform strategies to reduce the youth justice system’s reliance on confinement facilities and serve as many youths as possible in their own homes or at least in their own communities when removal from the home is warranted. The various reform strategies may be conceptualized as relying on three distinct but interrelated mechanisms: resolution, reinvestment, and realignment (Butts and Evans 2011). Resolution refers to the use of managerial authority and administrative directives to influence system change; reinvestment entails using financial incentives to encourage system change, and realignment employs organizational and …
Production Of Mycobacterial Cell Wall Glycopeptidolipids Requires A Member Of The Mbth-Like Protein Family, Elizabeth Tatham, Sivagami Sundaram Chavadi, Poornima Mohandas, Uthamaphani R. Edupuganti, Shiva K. Angala, Delphi Chatterjee, Luis E N Quadri
Production Of Mycobacterial Cell Wall Glycopeptidolipids Requires A Member Of The Mbth-Like Protein Family, Elizabeth Tatham, Sivagami Sundaram Chavadi, Poornima Mohandas, Uthamaphani R. Edupuganti, Shiva K. Angala, Delphi Chatterjee, Luis E N Quadri
Publications and Research
Background Glycopeptidolipids (GPLs) are among the major free glycolipid components of the outer membrane of several saprophytic and clinically-relevant Mycobacterium species. The architecture of GPLs is based on a constant tripeptide-amino alcohol core of nonribosomal peptide synthetase origin that is N-acylated with a 3-hydroxy/methoxy acyl chain synthesized by a polyketide synthase and further decorated with variable glycosylation patterns built from methylated and acetylated sugars. GPLs have been implicated in many aspects of mycobacterial biology, thus highlighting the significance of gaining an understanding of their biosynthesis. Our bioinformatics analysis revealed that every GPL biosynthetic gene cluster known to date contains a …
Coordination Between Proteasome Impairment And Caspase Activation Leading To Tau Pathology: Neuroprotection By Camp, M. J. Metcalfe, Q. Huang, Maria E. Figueiredo-Pereira
Coordination Between Proteasome Impairment And Caspase Activation Leading To Tau Pathology: Neuroprotection By Camp, M. J. Metcalfe, Q. Huang, Maria E. Figueiredo-Pereira
Publications and Research
Neurofibrillary tangles (NFTs) are hallmarks of Alzheimer’s disease (AD). The main component of NFTs is TAU, a highly soluble microtubule-associated protein. However, when TAU is cleaved at Asp421 by caspases it becomes prone to aggregation leading to NFTs. What triggers caspase activation resulting in TAU cleavage remains unclear. We investigated in rat cortical neurons a potential coordination between proteasome impairment and caspase activation. We demonstrate that upon proteasome inhibition, the early accumulation of detergent-soluble ubiquitinated (SUb) proteins paves the way to caspase activation and TAU pathology. This occurs with two drugs that inhibit the proteasome by different means: the product …
The Greek Crisis As Racketeering And Organized Crime, Despina Lalaki
The Greek Crisis As Racketeering And Organized Crime, Despina Lalaki
Publications and Research
No abstract provided.
Meta-Radicalism: The Alternative Press By And For Activist Librarians, Alycia Sellie
Meta-Radicalism: The Alternative Press By And For Activist Librarians, Alycia Sellie
Publications and Research
No abstract provided.
The French Prison System: Comparative Insights For Policy And Practice In New York And The United States, Lila Kazemian, Catrin Andersson
The French Prison System: Comparative Insights For Policy And Practice In New York And The United States, Lila Kazemian, Catrin Andersson
Publications and Research
Despite many differences between French and American correctional practices, the two countries have common challenges as well. This report offers a brief overview of the French prison system and describes how the elements of that system compare with the policies and practices of corrections agencies in New York and the United States.
Blending, Mixing, And Processing: Strategies Used To Engage Students In The Classroom, Mark Aaron Polger, Karen Okamoto
Blending, Mixing, And Processing: Strategies Used To Engage Students In The Classroom, Mark Aaron Polger, Karen Okamoto
Publications and Research
No abstract provided.
Twenty Years After: Armenian Research Libraries Today, D. Aram Donabedian, John Carey, Arshak Balayan
Twenty Years After: Armenian Research Libraries Today, D. Aram Donabedian, John Carey, Arshak Balayan
Publications and Research
Since achieving statehood in 1991, Armenia has faced major economic and political obstacles which have significantly affected the nation’s research libraries. This research paper will quantitatively and qualitatively examine the challenges facing Armenian research libraries just over twenty years after the collapse of the Soviet Union. Specifically, the authors analyze their interviews with five library administrators at five major institutions, respectively. These include Yerevan State University Library, the National Library of Armenia, the Fundamental Scientific Library of the National Academy of Sciences of Armenia, the Republican Scientific-Medical Library of Armenia, and the Papazian Library of the American University of Armenia. …
The Manufacture Of Lifestyle: The Role Of Corporations In Unhealthy Living, Nicholas Freudenberg
The Manufacture Of Lifestyle: The Role Of Corporations In Unhealthy Living, Nicholas Freudenberg
Publications and Research
Recently, researchers have debated two views on the connection between lifestyle and health. In the first, health-related lifestyles including tobacco and alcohol use, diet, and physical activity are seen as primary influences on health. In the second, social stratification is the dominant influence with lifestyles simply markers of social status. Neither approach leads to interventions that can reverse the world's most serious health problems. This article proposes that corporate practices are a dominant influence on the lifestyles that shape patterns of health and disease. Modifying business practices that promote unhealthy lifestyles is a promising strategy for improving population health. Corporations …
High Tech Tethers And Work-Family Conflict: A Conservation Of Resources Approach, Katherine M. Richardson, Cynthia A. Thompson
High Tech Tethers And Work-Family Conflict: A Conservation Of Resources Approach, Katherine M. Richardson, Cynthia A. Thompson
Publications and Research
This is one of the first studies to empirically examine the relationship between wireless communications technology and work interference with family, and results shed light on the motivating factors that influence individuals to continuously engage with mobile technologies, sometimes to their personal detriment. We draw from Conservation of Resources (COR) theory to examine the relationship between using mobile communications technologies during non-work time (e.g., evenings, weekends, vacation) and psychological variables related to work-family conflict and well being, and whether this relationship is mediated by perceptions of job control and detachment from work. We collected data from 139 full-time working adults …
Off To Market We Go: A Content Analysis Of Marketing And Promotion Skills In Academic Librarian Job Ads, Karen Okamoto, Mark Aaron Polger
Off To Market We Go: A Content Analysis Of Marketing And Promotion Skills In Academic Librarian Job Ads, Karen Okamoto, Mark Aaron Polger
Publications and Research
This exploratory study analyzed the presence of marketing and promotional responsibilities and qualifications listed in selected job advertisements for academic librarians. A content analysis was employed to analyze job advertisements for academic librarians who possessed marketing,promotion, public relations, outreach, and liaison skills. Job advertisements were selected from January 2000 to December 2010. A total of 149 advertisements were analyzed. The authors found that promotional responsibilities were advertised across the 10-year period, but marketing responsibilities were not. Prior promotional and marketing experience was not widely required. Some libraries advertised marketing librarian positions with responsibilities such as branding and social networking. The …
Polyglutamine Toxicity Is Controlled By Prion Composition And Gene Dosage In Yeast, He Gong, Nina V. Romanova, Kim D. Allen, Pavithra Chandramowlishwaran, Kavita Gokhale, Gary P. Newnam, Piotr Miceczkowski, Michael Y. Sherman, Yury O. Chernoff
Polyglutamine Toxicity Is Controlled By Prion Composition And Gene Dosage In Yeast, He Gong, Nina V. Romanova, Kim D. Allen, Pavithra Chandramowlishwaran, Kavita Gokhale, Gary P. Newnam, Piotr Miceczkowski, Michael Y. Sherman, Yury O. Chernoff
Publications and Research
Polyglutamine expansion causes diseases in humans and other mammals. One example is Huntington’s disease. Fragments of human huntingtin protein having an expanded polyglutamine stretch form aggregates and cause cytotoxicity in yeast cells bearing endogenous QN-rich proteins in the aggregated (prion) form. Attachment of the proline(P)-rich region targets polyglutamines to the large perinuclear deposit (aggresome). Aggresome formation ameliorates polyglutamine cytotoxicity in cells containing only the prion form of Rnq1 protein. Here we show that expanded polyglutamines both with (poly-QP) or without (poly-Q) a P-rich stretch remain toxic in the presence of the prion form of translation termination (release) factor Sup35 (eRF3). …
From Art On The Wall To Something For All: How An Academic Library Turned Its Art Collection Into A Campus Attraction, Miriam B. Deutch, Jill Cirasella
From Art On The Wall To Something For All: How An Academic Library Turned Its Art Collection Into A Campus Attraction, Miriam B. Deutch, Jill Cirasella
Publications and Research
An important feature of the Brooklyn College Library is its art collection, the college’s only permanent art collection. In this article, we explain how the library came to have an art collection; how we supplemented the collection with museum-style wall labels, an online catalog, and an audio tour; and how we promoted the collection and sparked student creativity with an annual art contest. We pay particular attention to the decisions and details that might help other libraries working on similar projects.
Dismantling The Monolith: Post-Media Art And The Culture Of Instability, Nora Almeida
Dismantling The Monolith: Post-Media Art And The Culture Of Instability, Nora Almeida
Publications and Research
Art that falls under the “new media” paradigm is problematic, or rather, it renders many traditional assumptions about art as problematic. In a practical sense, new media art raises fundamental questions about the nature of curation and preservation and the role of cultural heritage institutions as stewards of digital assets. Curation and preservation challenges, while significant, are fundamentally a symptom of a more catastrophic failure of concepts and language to adequately address changing relationships between art, materiality, and audiences. This article explores how burgeoning concepts in information and media theory may help shape curation contexts and redefine approaches to preservation. …
Transforming Student Engagement Through Documentary And Critical Media Literacy, Jessie Daniels
Transforming Student Engagement Through Documentary And Critical Media Literacy, Jessie Daniels
Publications and Research
Young people entering college today have grown up in a multimedia environment, yet the classroom they most often encounter reflects nineteenth-century pedagogy. This paper explores the paradigm shift that is making documentaries more widely accessible for use in the classroom; describes a pedagogical strategy for connecting a critical media literacy ‘reading’ of documentaries with more traditional reading of written texts; investigates the effectiveness of this method to engage students through critical media literacy in ways that encourage transformation. Effectiveness was measured in a voluntary, self-reported questionnaire, emailed to students after the semester they took Introductory Sociology. Students in the sample …
From Art On The Wall To Something For All: How An Academic Library Turned Its Art Collection Into A Campus Attraction, Jill Cirasella, Miriam Deutch
From Art On The Wall To Something For All: How An Academic Library Turned Its Art Collection Into A Campus Attraction, Jill Cirasella, Miriam Deutch
Publications and Research
An important feature of the Brooklyn College Library is its art collection, the college’s only permanent art collection. In this article, we explain how the library came to have an art collection; how we supplemented the collection with museum-style wall labels, an online catalog, and an audio tour; and how we promoted the collection and sparked student creativity with an annual art contest. We pay particular attention to the decisions and details that might help other libraries working on similar projects.
Delegated Performance: Outsourcing Authenticity, Claire Bishop
Delegated Performance: Outsourcing Authenticity, Claire Bishop
Publications and Research
An essay is presented on delegated performance in which nonprofessionals are hired to perform at a particular time on behalf of the artist on his or her instructions. The author stated that this social turn started since 1990s in contemporary art against the tradition of 1960s and 1970s where artists like Chris Burden, Vito Acconci and Gina Pane performed themselves. The author referred to the trend of live installation started in Europe in 1990s in which guards for exhibition were hired. The Italian artist Maurizio Cattelan assembled a soccer club of foreigners to play local matches in 1991.
Correlated Components Of Ongoing Eeg Point To Emotionally Laden Attention – A Possible Marker Of Engagement?, Jacek P. Dmochowski, Paul Sajda, Joao Dias, Lucas C. Parra
Correlated Components Of Ongoing Eeg Point To Emotionally Laden Attention – A Possible Marker Of Engagement?, Jacek P. Dmochowski, Paul Sajda, Joao Dias, Lucas C. Parra
Publications and Research
Recent evidence from functional magnetic resonance imaging suggests that cortical hemodynamic responses coincide in different subjects experiencing a common naturalistic stimulus. Here we utilize neural responses in the electroencephalogram (EEG) evoked by multiple presentations of short film clips to index brain states marked by high levels of correlation within and across subjects. We formulate a novel signal decomposition method which extracts maximally correlated signal components from multiple EEG records. The resulting components capture correlations down to a one-second time resolution, thus revealing that peak correlations of neural activity across viewings can occur in remarkable correspondence with arousing moments of the …