Digital Commons Network^™

Law Enforcement And The Mentally Ill: Thirty Years Of Police Literature, Jennifer Noe

Publications and Research

This study applies the methodology of content analysis to 30 years of law-enforcement literature to determine whether online access to scholarly research in social work and mental health made a difference in police policy toward the mentally ill. Keywords from the controlled vocabulary of these fields were found in the body of content analyzed prior to easily accessible online resources in 1997 , yet the number of articles on the subject grew from approximately one per year prior to 1998 to nearly five per year by 2011. The imprint of these two fields from outside of law enforcement was discernible …

Mutation Of Simple In Charcot–Marie–Tooth 1c Alters Production Of Exosomes, Hong Zhu, Sara Guariglia, Raymond Y. L. Yu, Wenjing Li, Deborah Brancho, Hector Peinado, David Lyden, James Salzer, Craig Bennett, Chi-Wing Chow

Publications and Research

Mutations in the protein SIMPLE account for the rare autosomal-dominant demyelination in type 1C CMT patients (CMT1C). SIMPLE plays a role in the production of exosomes. Dysregulated endosomal trafficking and changes in exosome-mediated intercellular communications might account for CMT1C molecular pathogenesis.

Access To Hiv/Aids Care: A Systematic Review Of Socio-Cultural Determinants In Low And High Income Countries, Sara Gari, Camilo Doig-Acuña, Tino Smail, Jacob Rs Malungo, Adriane Martin-Hilber, Sonja Merten

Publications and Research

Background The role of socio-cultural factors in influencing access to HIV/AIDS treatment, care and support is increasingly recognized by researchers, international donors and policy makers. Although many of them have been identified through qualitative studies, the evidence gathered by quantitative studies has not been systematically analysed. To fill this knowledge gap, we did a systematic review of quantitative studies comparing surveys done in high and low income countries to assess the extent to which socio-cultural determinants of access, identified through qualitative studies, have been addressed in epidemiological survey studies. Methods Ten electronic databases were searched (Cinahl, EMBASE, ISI Web of …

Lim Protein Ajuba Participates In The Repression Of The Atr-Mediated Dna Damage Response, Sampada Kalan, Anastasiya Matveyenko, Diego Loayza

Publications and Research

LIM proteins constitute a superfamily characterized by the presence of a LIM domain, known to be involved in protein–protein interactions. Our previous work has implicated members of the Zyxin family of LIM proteins, namely TRIP6 and LPP, in the repression of the DNA damage response (DDR) at telomeres. Here, we describe a role for Ajuba, a closely related LIM molecule, in repressing the ATR-mediated DDR. We found that depletion of Ajuba led to apparent delays in the cell cycle, accompanied with increased Rb phosphorylation, Chk1 phosphorylation, induction of p53, and cell death. Ajuba could be found in a complex with …

Synergistic Inhibition Of Survival, Proliferation, And Migration Of U87 Cells With A Combination Of Ly341495 And Iressa, Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S. Mahajan

Publications and Research

Glioblastomas exploit various molecular pathways to promote glutamate-dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal growth factor receptor, EGFR. We hypothesized that targeting more than one of these pathways would be more effective in inhibiting glutamate-dependent growth. Using a model of U87 cell line, we show that blocking glutamate release by Riluzole inhibits cell proliferation. Glutamate-dependent growth is effectively inhibited by a combination of Iressa, an inhibitor of EGFR activation and LY341495, a group II mGluR inhibitor. Treatment of U87 cells with a combination of Iressa and LY341495 …

Flurbiprofen Benzyl Nitrate (Nbs-242) Inhibits The Growth Of A-431 Human Epidermoid Carcinoma Cells And Targets Β-Catenin, Niharika Nath, Xiaoping Liu, Lloydine Jacobs, Khosrow Kashfi

Publications and Research

Background: The Wnt/β-catenin/T cell factor (TCF) signaling pathway is important in the development of nonmelanoma skin cancers (NMSCs). Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemopreventive agents consisting of a traditional NSAID attached to an NO-releasing moiety through a chemical spacer. Previously we showed that an aromatic spacer enhanced the potency of a particular NO-NSAID compared to an aliphatic spacer.

Methods: We synthesized an NO-releasing NSAID with an aromatic spacer (flurbiprofen benzyl nitrate, NBS-242), and using the human skin cancer cell line A-431, we evaluated its effects on cell kinetics, Wnt/β-catenin, cyclin D1, and caspase-3.

Results: NBS-242 inhibited the growth of …

An Improved Clearing And Mounting Solution To Replace Chloral Hydrate In Microscopic Applications1, Thomas S. Villani, Adolfina R. Koroch, James E. Simon

Publications and Research

• Premise of the study: This study presents Visikol™, a new proprietary formulation that can be used as an efficient replacement for chloral hydrate as a clearing agent for microscopic examination. In the United States, chloral hydrate is regulated and therefore difficult to acquire. • Methods and Results: Fresh and dry samples of the following plants: ginger (Zingiber officinale), maté (Ilex paraguariensis), lime basil (Ocimum americanum), oregano (Origanum vulgare), and mouse-ear cress (Arabidopsis thaliana), were cleared using Visikol or chloral hydrate solution and compared using a light microscope. • Conclusions: This new method can be used successfully to clear specimens, …

Origins Of Power-Law Degree Distribution In The Heterogeneity Of Human Activity In Social Networks, Lev Muchnik, Sen Pei, Lucas C. Parra, Saulo D. S. Reis, José S. Andrade Jr, Shlomo Havlin, Hernán A. Makse

Publications and Research

The probability distribution of number of ties of an individual in a social network follows a scale-free power-law. However, how this distribution arises has not been conclusively demonstrated in direct analyses of people's actions in social networks. Here, we perform a causal inference analysis and find an underlying cause for this phenomenon. Our analysis indicates that heavy-tailed degree distribution is causally determined by similarly skewed distribution of human activity. Specifically, the degree of an individual is entirely random - following a “maximum entropy attachment” model - except for its mean value which depends deterministically on the volume of the users' …

Habitat And Host Indicate Lineage Identity In Colletotrichum Gloeosporioides S.L. From Wild And Agricultural Landscapes In North America, Vinson P. Doyle, Peter V. Oudemans, Stephen A. Rehner, Amy Litt

Publications and Research

Understanding the factors that drive the evolution of pathogenic fungi is central to revealing the mechanisms of virulence and host preference, as well as developing effective disease control measures. Prerequisite to these pursuits is the accurate delimitation of species boundaries. Colletotrichum gloeosporioides s.l. is a species complex of plant pathogens and endophytic fungi for which reliable species recognition has only recently become possible through a multi-locus phylogenetic approach. By adopting an intensive regional sampling strategy encompassing multiple hosts within and beyond agricultural zones associated with cranberry (Vaccinium macrocarpon Aiton), we have integrated North America strains of Colletotrichum gloeosporioides s.l. from …

Burden Of Disease From Toxic Waste Sites In India, Indonesia, And The Philippines In 2010, Kevin Chatham-Stephens, Jack Caravanos, Bret Ericson, Jennifer Sunga-Amparo, Budi Susilorini, Promila Sharma, Philip J. Landrigan, Richard Fuller

Publications and Research

Background: Prior calculations of the burden of disease from toxic exposures have not included estimates of the burden from toxic waste sites due to the absence of exposure data. Objective: We developed a disability-adjusted life year (DALY)-based estimate of the disease burden attributable to toxic waste sites. We focused on three low- and middle-income countries (LMICs): India, Indonesia, and the Philippines. Methods: Sites were identified through the Blacksmith Institute’s Toxic Sites Identification Program, a global effort to identify waste sites in LMICs. At least one of eight toxic chemicals was sampled in environmental media at each site, and the population …

Flying Off The Shelf: E-Books Go Mobile, Madeline Cohen, Stefanie Havelka, Jennifer Poggiali, Kate Lyons, Elisabeth Tappeiner

Publications and Research

On May 3, 2013, the two Hostos librarians teamed up with two librarians of Lehman College’s Leonard Lief Library at the Bronx EdTech Showcase to address the challenges and joys of e-books. Their hour-long presentation, focused on trends in ebooks, technical issues such as DRM and formats, CUNY’s eBook collections, and the challenges of informing students and faculty about e-books.

A Phylogeny And Revised Classification Of Squamata, Including 4161 Species Of Lizards And Snakes, R. Alexander Pyron, Frank T. Burbrink, John J. Wiens

Publications and Research

Background: The extant squamates (>9400 known species of lizards and snakes) are one of the most diverse and conspicuous radiations of terrestrial vertebrates, but no studies have attempted to reconstruct a phylogeny for the group with large-scale taxon sampling. Such an estimate is invaluable for comparative evolutionary studies, and to address their classification. Here, we present the first large-scale phylogenetic estimate for Squamata.

Results: The estimated phylogeny contains 4161 species, representing all currently recognized families and subfamilies. The analysis is based on up to 12896 base pairs of sequence data per species (average = 2497 bp) from 12 genes, …

Neural Processing Of Facial Identity And Emotion In Infants At High-Risk For Autism Spectrum Disorders, Sharon E. Fox, Jennifer B. Wagner, Christine L. Shrock, Helen Tager-Flusberg, Charles A. Nelson

Publications and Research

Deficits in face processing and social impairment are core characteristics of autism spectrum disorder. The present work examined 7-month-old infants at high-risk for developing autism and typically developing controls at low-risk, using a face perception task designed to differentiate between the effects of face identity and facial emotions on neural response using functional Near-Infrared Spectroscopy. In addition, we employed independent component analysis, as well as a novel method of condition-related component selection and classification to identify group differences in hemodynamic wave forms and response distributions associated with face and emotion processing.The results indicate similarities of waveforms, but differences in the …

The Battle Of Brooklyn: World City And Space Of Neighborhoods., Benjamin C. Shepard

Publications and Research

Throughout Brooklyn, regular people are fighting off the negative dynamics of urban experience, including uneven development, speculative gentrification, displacement, and police brutality long seen in global cities. Yet, little of the global cities literature considers the ways local actors impact global forces shaping world cities. Instead, observers of globalization suggest local actors have been relegated the sidelines as passive spectators of larger social and economic forces. Many wonder, is there a space for agency in global cities? Can regular people shape the dynamics of life in cities? For many, the answer is clearly affirmative. Throughout the borough of Brooklyn, people …

The Impact Of Demographics On 21st Century Education, Norman Eng

Publications and Research

Do all students need STEM education or should it be focused primarily on the mathematically and scientifically inclined? Here, demographics may hold the key to such questions from which a 21st century education model should be based on.

Do You See The Signs? Evaluating Language, Branding, And Design In A Library Signage Audit, Amy F. Stempler, Mark Aaron Polger

Publications and Research

Signage represents more than directions or policies; it is informational, promotional, and sets the tone of the environment. To be effective, signage must be consistent, concise, and free of jargon and punitive language. An efficient assessment of signage should include a complete inventory of existing signage, including an analysis of the types of signs, its location, language, and its design. This article outlines the steps involved in a comprehensive signage audit, which along with a literature review, provides the foundation for creating a signage policy, best practices guidelines, and a branding strategy for future signage.

Friendship, Education, And Justice Teaching: The Professional Development Of Two Teacher-Friends, Debbie Sonu

Publications and Research

This paper discusses the distinct nature of friendship between teachers. Using literature on both the philosophical study of friendship and that of professional development, I present data from a qualitative study with two elementary school teachers in New York City in order to explore how the benefits of friendship might deepen an understanding of one's work with students. While literature on professional development tends to focus on effectively designed and structured activity, this article highlights the importance of teacher amity in (a) staving off negative judgments about teacher work, (b) harnessing the freedom to create and err, and (c) cultivating …

A Novel Cell-Based Hybrid Acoustic Wave Biosensor With Impedimetric Sensing Capabilities, Fei Liu, Fang Li, Anis Nurashikin Nordin, Ioana Voiculescu

Publications and Research

A novel multiparametric biosensor system based on living cells will be presented. The biosensor system includes two biosensing techniques on a single device: resonant frequency measurements and electric cell-substrate impedance sensing (ECIS). The multiparametric sensor system is based on the innovative use of the upper electrode of a quartz crystal microbalance (QCM) resonator as working electrode for the ECIS technique. The QCM acoustic wave sensor consists of a thin AT-cut quartz substrate with two gold electrodes on opposite sides. For integration of the QCM with the ECIS technique a semicircular counter electrode was fabricated near the upper electrode on the …

Isoflurane Increases Neuronal Cell Death Vulnerability By Downregulating Mir-214, Hailiang Yan, Tao Xu, Hongfeng Zhao, Kuo-Chieh Lee, Hoau-Yan Wang, Yan Zhang

Publications and Research

Since accumulating evidence suggests the application of anesthetics may increase the risk of Alzheimer’s disease (AD), we investigated the cytotoxicity of inhaled general anesthesia in neurons and its underlying mechanism. Using primary cultured rat hippocampal neurons as the study model, here we show that isoflurane increases vulnerability to intracellular or extracellular amyloid b with or without serum deprivation. This isoflurane-induced effect is mediated by the downregulation of miR-214 level that lead to an elevated expression of Bax, a prominent target for miR-214. We conclude that isoflurane increases cell death in the presence of amyloid b by increasing Bax level through …

Cuny's Critical Thinking Skills Initiative: Redesigning Workforce Education Through Information Literacy Learning, Irene Gashurov, Ann Matsuuchi

Publications and Research

In the wake of the recent financial upheaval, there is a feeling in academia that colleges should pay more attention to what employers are saying; and the common concern of employers is that many new hires are coming out of college unprepared.

In job situations that demand approaching problems from a variety of perspectives, using innovative approaches to find solutions, and communicating effectively, employers said these recent graduates were coming up short. They called on educators “to teach [students] the analytical skills, the critical thinking skills and the communication skills that are necessary for almost every job in today’s economy.”

Searching Mindfully: Are Libraries Up To The Challenge Of Competing With Google Books?, Amrita Dhawan

Publications and Research

Traditional research tools used by libraries, such as encyclopedias and catalogs (OPACs) were created in an age of print and information scarcity. They have not kept up with changes in the information world which assume an abundance of online information in different formats and interdisciplinary topics which attempt to solve ‘real world’ messy problems and not traditional theoretical questions. The traditional tools rest on an unwieldy and somewhat outdated collaboration between OCLC, LOC, private aggregators, librarians and faculty. The search results they deliver offer excessive information with very little guidance on how to systematically sift through them. This makes the …

Multiple Breast Cancer Cell-Lines Derived From A Single Tumor Differ In Their Molecular Characteristics And Tumorigenic Potential, Goar Mosoyan, Chandandeep Nagi, Svetlana Marukian, Avelino Teixeira, Anait Simonian, Lois Resnick-Silverman, Analisa Difeo, Dean Johnston, Sandra R. Reynolds, Daniel F. Roses, Arevik Mosoian

Publications and Research

Background Breast cancer cell lines are widely used tools to investigate breast cancer biology and to develop new therapies. Breast cancer tissue contains molecularly heterogeneous cell populations. Thus, it is important to understand which cell lines best represent the primary tumor and have similarly diverse phenotype. Here, we describe the development of five breast cancer cell lines from a single patient’s breast cancer tissue. We characterize the molecular profiles, tumorigenicity and metastatic ability in vivo of all five cell lines and compare their responsiveness to 4-hydroxytamoxifen (4-OHT) treatment. Methods Five breast cancer cell lines were derived from a single patient’s …

Motivational Interviewing Targeting Risk Behaviors For Youth Living With Hiv In Thailand, Chokechai Rongkavilit, Sylvie Naar-King, Bo Wang, Apirudee Panthong, Torsak Bunupuradah, Jeffrey T. Parsons, Supalak Phonphithak, Juline A. Koken, Pichai Saengcharnchai, Praphan Phanuphak

Publications and Research

Healthy Choices, a four-session motivational interviewing-based intervention, reduces risk behaviors among US youth living with HIV (YLWH). We randomized 110 Thai YLWH (16–25 years) to receive either Healthy Choices or time-matched health education (Control) over 12 weeks. Risk behaviors were assessed at baseline, 1, and 6 months post-session. The pilot study was not powered for between-group differences; there were no statistical differences in sexual risks, alcohol use, and antiretroviral adherence between the two groups at any visit. In within-group analyses, Healthy Choices group demonstrated decreases in the proportion of HIV-negative partners (20 vs 8.2 %, P = 0.03) and HIV …

Serum Amyloid P Inhibits Granulocyte Adhesion, Anu S. Maharjan, David Roife, Derrick Brazill, Richard H. Gomer

Publications and Research

Background The extravasation of granulocytes (such as neutrophils) at a site of inflammation is a key aspect of the innate immune system. Signals from the site of inflammation upregulate granulocyte adhesion to the endothelium to initiate extravasation, and also enhance granulocyte adhesion to extracellular matrix proteins to facilitate granulocyte movement through the inflamed tissue. During the resolution of inflammation, other signals inhibit granulocyte adhesion to slow and ultimately stop granulocyte influx into the tissue. In a variety of inflammatory diseases such as acute respiratory distress syndrome, an excess infiltration of granulocytes into a tissue causes undesired collateral damage, and being …

Tolerance Of Roadside And Old Field Populations Of Common Teasel (Dipsacus Fullonum Subsp. Sylvestris) To Salt And Low Osmotic Potentials During Germination, Laura L. Beaton, Susan A. Dudley

Publications and Research

Maternal families from roadside populations of Dipsacus fullonum subsp. sylvestris displayed greater tolerance of both high salinity and drought during germination than families from old field populations. However, the tolerances were not correlated, indicating that they are separate traits.

Changes In Natural Killer Cell Activation And Function During Primary Hiv-1 Infection, Vivek Naranbhai, Marcus Altfeld, Salim S. Abdool Karim, Thumbi Ndung’U, Quarraisha Abdool Karim, William H. Carr

Publications and Research

Background: Recent reports suggest that Natural Killer (NK) cells may modulate pathogenesis of primary HIV-1 infection. However, HIV dysregulates NK-cell responses. We dissected this bi-directional relationship to understand how HIV impacts NK-cell responses during primary HIV-1 infection.

Methodology/Principal Findings: Paired samples from 41 high-risk, initially HIV-uninfected CAPRISA004 participants were analysed prior to HIV acquisition, and during viraemic primary HIV-1 infection. At the time of sampling post-infection five women were seronegative, 11 women were serodiscordant, and 25 women were seropositive by HIV-1 rapid immunoassay. Flow cytometry was used to measure NK and T-cell activation, NK-cell receptor expression, cytotoxic and cytokine-secretory functions, …

Autophagy Plays An Essential Role In Mediating Regression Of Hypertrophy During Unloading Of The Heart, Nirmala Hariharan, Yoshiyuki Ikeda, Chull Hong, Ralph R. Alcendor, Soichiro Usui, Shumin Gao, Yasuhiro Maejima, Junichi Sadoshima

Publications and Research

Autophagy is a bulk degradation mechanism for cytosolic proteins and organelles. The heart undergoes hypertrophy in response to mechanical load but hypertrophy can regress upon unloading. We hypothesize that autophagy plays an important role in mediating regression of cardiac hypertrophy during unloading. Mice were subjected to transverse aortic constriction (TAC) for 1 week, after which the constriction was removed (DeTAC). Regression of cardiac hypertrophy was observed after DeTAC, as indicated by reduction of LVW/BW and cardiomyocyte cross-sectional area. Indicators of autophagy, including LC3-II expression, p62 degradation and GFP-LC3 dots/cell, were significantly increased after DeTAC, suggesting that autophagy is induced. Stimulation …

From Toxic Tours To Growing The Grassroots: Tensions In Critical Pedagogy And Community Development, Celina Su, Isabelle Jagninski

Publications and Research

Structural inequalities in American public education are inextricably tied to deep-seated patterns of racial and economic segregation. Children in poor neighborhoods are less likely to have the household resources, neighborhood institutions, or school amenities necessary for a good, challenging education. In response, a growing number of organizations have launched initiatives to simultaneously revitalize neighborhoods and improve public education, emphasizing youth participation as an essential component in their efforts. We draw upon ethnographic data from two such organizations to examine their practice of place-based critical pedagogy in community development. We focus on how they engage marginalized, “hard-to-reach” youth via (1) experiential …

Reflections On Vawa's Strange Bedfellows: The Partnership Between The Battered Immigrant Women's Movement And Law Enforcement, Alizabeth Newman

Publications and Research

No abstract provided.

Is Anyone Regulating?: The Curious State Of Gmo Governance In The United States, Rebecca Bratspies

Publications and Research

No abstract provided.