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“Documenting The Untold Stories Of Feminist Activists At Welfare Rights Initiative: A Digital Oral History Archive Project.”, Cynthia Tobar Apr 2014

“Documenting The Untold Stories Of Feminist Activists At Welfare Rights Initiative: A Digital Oral History Archive Project.”, Cynthia Tobar

Publications and Research

This chapter recounts the creation of a digital oral history archive documenting the Welfare Rights Initiative (WRI), a grassroots student activist and community leadership training organization located at Hunter College. The author examines, through these oral history interviews, social movement activity at the level of a grassroots organization as exemplified by WRI, which was developed to aid student welfare recipients to become agents of social change and actively involve them with policymaking. The project depicts the experiences of members in this feminist grassroots organization and provides us with new insights to the origins of advocacy, documenting the singular historical importance …


Open Access, Jill Cirasella Apr 2014

Open Access, Jill Cirasella

Publications and Research

This article describes some problems with the traditional system of scholarly journal publishing and explains how scholars can make their works open access, or freely available online. It also discusses some of the benefits of open access, as well as some of the challenges to achieving widespread openness.


El Pasado Lingüístico Colonial Y Las Lenguas De Instrucción En La Educación Filipina, David Sánchez-Jiménez Apr 2014

El Pasado Lingüístico Colonial Y Las Lenguas De Instrucción En La Educación Filipina, David Sánchez-Jiménez

Publications and Research

No abstract provided.


Markdown For Librarians And Academics, Steven Ovadia Apr 2014

Markdown For Librarians And Academics, Steven Ovadia

Publications and Research

The article offers information related to Markdown, a flexible markup language that allows text to be easily converted to different formats and has implications as a way to make academic content mroe shareable.


Out With The Old, In With The New: Best Practices For Replacing Library Signage, Mark Aaron Polger, Amy F. Stempler Apr 2014

Out With The Old, In With The New: Best Practices For Replacing Library Signage, Mark Aaron Polger, Amy F. Stempler

Publications and Research

Signage is an essential way of communicating with users and is a vital way to alert patrons to important information, news, upcoming events, policies, and directions. Literature on library signage has emphasized the importance of consistency and clarity, to avoid clutter and contradictory messaging, and the need for buy-in from library staff, faculty and patrons. However, few scholarly studies address user preferences in signage. This article fills the void between theory and practice, and offers step-by-step details for revamping signage, specifically in an academic library. At the heart of the authors’ thesis is that library signs are living documents. Libraries …


A Vision For Inclusion: An Lgbt Broadband Future, Jessie Daniels, Mary L. Gray Apr 2014

A Vision For Inclusion: An Lgbt Broadband Future, Jessie Daniels, Mary L. Gray

Publications and Research

This report provides an overview of the current scholarship and policy around the particular needs of LGBT people and the Internet.


Diy Urbanism As An Environmental Justice Strategy: The Case Study Of Time's Up! 1987-2012, Benjamin C. Shepard Apr 2014

Diy Urbanism As An Environmental Justice Strategy: The Case Study Of Time's Up! 1987-2012, Benjamin C. Shepard

Publications and Research

Time's Up! is a New York environmental group which promotes nonpolluting transportation and sustainable solutions to an urban problems. Over the last twenty-five years, the group has taken a do-it-yourself approach to an environmental activism, bridging neighborhood, global justice, and occupy movements. With roots in the squatter movement in New York, Time's Up! has built its own distinct brand of DIY urbanism to fight for community gardens, support group bike rides, and create sustainable approaches to an urban living. While the group makes use of a wide range of approaches to reclaim public space, direct action is its guiding principle. …


Functionally Distinct Pi 3-Kinase Pathways Regulate Myelination In The Peripheral Nervous System, Bradley A. Heller, Monica Ghidinelli, Jakob Voelkl, Steven Einheber, Ryan Smith, Ethan Grund, Grant Morahan, David Chandler, Luba Kalaydjieva, Filippo Giancotti, Rosalind H. King, Aniko Naray Fejes-Toth, Gerard Fejes-Toth, Maria Laura Feltri, Florian Lang, James L. Salzer Mar 2014

Functionally Distinct Pi 3-Kinase Pathways Regulate Myelination In The Peripheral Nervous System, Bradley A. Heller, Monica Ghidinelli, Jakob Voelkl, Steven Einheber, Ryan Smith, Ethan Grund, Grant Morahan, David Chandler, Luba Kalaydjieva, Filippo Giancotti, Rosalind H. King, Aniko Naray Fejes-Toth, Gerard Fejes-Toth, Maria Laura Feltri, Florian Lang, James L. Salzer

Publications and Research

Functionally and spatially distinct PI 3-K pathways act either early to promote myelination downstream of axonal Neuregulin1 or late to inhibit myelination downstream of α6β4 integrin and Sgk1.


Self-Assembled Hydrogel Fibers For Sensing The Multi-Compartment Intracellular Milieu, Praveen Kumar Vemula, Jonathan E. Kohler, Amy Blass, Miguel Williams, Chenjie Xu, Lynna Chen, Swapnil R. Jadhav, George John, David I. Soybel, Jeffrey M. Karp Mar 2014

Self-Assembled Hydrogel Fibers For Sensing The Multi-Compartment Intracellular Milieu, Praveen Kumar Vemula, Jonathan E. Kohler, Amy Blass, Miguel Williams, Chenjie Xu, Lynna Chen, Swapnil R. Jadhav, George John, David I. Soybel, Jeffrey M. Karp

Publications and Research

Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence on active transport, and inability to function within cellular compartments. Here, we developed self-assembled nanofibrous hydrogel fibers using a biologically inert, low-molecular-weight amphiphile. Self-assembled nanofibrous hydrogels offer unique physical/mechanical properties and can easily be loaded with a diverse range of payloads. Unlike commercially available E. coli membrane particles covalently bound to the pH reporting dye pHrodo, pHrodo encapsulated in self-assembled hydrogel-fibers internalizes into macrophages at both physiologic (37°C) and …


Multilocus Coalescent Analyses Reveal The Demographic History Of Mouse Lemur Sister Species., Christopher Blair, Kellie L. Heckman, Amy L. Russell, Anne D. Yoder Mar 2014

Multilocus Coalescent Analyses Reveal The Demographic History Of Mouse Lemur Sister Species., Christopher Blair, Kellie L. Heckman, Amy L. Russell, Anne D. Yoder

Publications and Research

Debate continues as to whether allopatric speciation or peripatric speciation through a founder effect is the predominant force driving evolution in vertebrates. The mouse lemurs of Madagascar are a system in which evolution has generated a large number of species over a relatively recent time frame. Here, we examine speciation patterns in a pair of sister species of mouse lemur, Microcebus murinus and M. griseorufus. These two species have ranges that are disparately proportioned in size, with M. murinus showing a much more extensive range that marginally overlaps that of M. griseorufus. Given that these two species are …


Evolutionary Cognitive Therapy Versus Standard Cognitive Therapy For Depression: A Protocol For A Blinded, Randomized, Superiority Clinical Trial, Cezar Giosan, Oana Cobeanu, Cristina Mogoase, Vlad Muresan, Loretta S. Malta, Katarzyna Wyka, Aurora Szentagotai Mar 2014

Evolutionary Cognitive Therapy Versus Standard Cognitive Therapy For Depression: A Protocol For A Blinded, Randomized, Superiority Clinical Trial, Cezar Giosan, Oana Cobeanu, Cristina Mogoase, Vlad Muresan, Loretta S. Malta, Katarzyna Wyka, Aurora Szentagotai

Publications and Research

Background: Depression is estimated to become the leading cause of disease burden globally by 2030. Despite existing efficacious treatments (both medical and psychotherapeutic), a large proportion of patients do not respond to therapy. Recent insights from evolutionary psychology suggest that, in addition to targeting the proximal causes of depression (for example, targeting dysfunctional beliefs by cognitive behavioral therapy), the distal or evolutionary causes (for example, inclusive fitness) should also be addressed. A randomized superiority trial is conducted to develop and test an evolutionary-driven cognitive therapy protocol for depression, and to compare its efficacy against standard cognitive therapy for depression.

Methods/design: …


Periodic Heat Shock Accelerated The Chondrogenic Differentiation Of Human Mesenchymal Stem Cells In Pellet Culture, Jing Chen, Chenghai Li, Sihong Wang Mar 2014

Periodic Heat Shock Accelerated The Chondrogenic Differentiation Of Human Mesenchymal Stem Cells In Pellet Culture, Jing Chen, Chenghai Li, Sihong Wang

Publications and Research

Osteoarthritis (OA) is one of diseases that seriously affect elderly people's quality of life. Human mesenchymal stem cells (hMSCs) offer a potential promise for the joint repair in OA patients. However, chondrogenic differentiation from hMSCs in vitro takes a long time (∼6 weeks) and differentiated cells are still not as functionally mature as primary isolated chondrocytes, though chemical stimulations and mechanical loading have been intensively studied to enhance the hMSC differentiation. On the other hand, thermal stimulations of hMSC chondrogenesis have not been well explored. In this study, the direct effects of mild heat shock (HS) on the differentiation of …


Altering Murine Leukemia Virus Integration Through Disruption Of The Integrase And Bet Protein Family Interaction, Sriram Aiyer, G.V.T. Swapna, Nirav Malani, James M. Aramini, William M. Schneider, Matthew R. Plumb, Mustafa Ghanem, Ross C. Larue, Amit Sharma, Barbara Studamire, Mamuka Kvaratskhelia, Frederic D. Bushman, Gaetano T. Montelione, Monica J. Roth Mar 2014

Altering Murine Leukemia Virus Integration Through Disruption Of The Integrase And Bet Protein Family Interaction, Sriram Aiyer, G.V.T. Swapna, Nirav Malani, James M. Aramini, William M. Schneider, Matthew R. Plumb, Mustafa Ghanem, Ross C. Larue, Amit Sharma, Barbara Studamire, Mamuka Kvaratskhelia, Frederic D. Bushman, Gaetano T. Montelione, Monica J. Roth

Publications and Research

We report alterations to the murine leukemia virus (MLV) integrase (IN) protein that successfully result in decreasing its integration frequency at transcription start sites and CpG islands, thereby reducing the potential for insertional activation. The host bromo and extraterminal (BET) proteins Brd2, 3 and 4 interact with the MLV IN protein primarily through the BET protein ET domain. Using solution NMR, protein interaction studies, and next generation sequencing, we showthat the C-terminal tail peptide region ofMLV IN is important for the interaction with BET proteins and that disruption of this interaction through truncation mutations affects the global targeting profile of …


Synergism Between Airborne Singlet Oxygen And A Trisubstituted Olefin Sulfonate For The Inactivation Of Bacteria, Rajib Choudhury, Alexander Greer Mar 2014

Synergism Between Airborne Singlet Oxygen And A Trisubstituted Olefin Sulfonate For The Inactivation Of Bacteria, Rajib Choudhury, Alexander Greer

Publications and Research

The reactivity of a trisubstituted alkene surfactant (8-methylnon-7-ene-1 sulfonate, 1) to airborne singlet oxygen in a solution containing E. coli was examined. Surfactant 1 was prepared by a Strecker-type reaction of 9-bromo-2-methylnon-2-ene with sodium sulfite. Submicellar concentrations of 1 were used that reacted with singlet oxygen by an “ene” reaction to yield two hydroperoxides (7-hydroperoxy-8-methylnon-8-ene-1 sulfonate and (E)-8-hydroperoxy-8-methylnon-6-ene-1 sulfonate) in a 4:1 ratio. Exchanging the H2O solution for D2O where the lifetime of solution-phase singlet oxygen increases by 20-fold led to an ∼2-fold increase in the yield of hydroperoxides pointing to surface activity …


Engaging Academics And Reimagining Scholarly Communication For The Public Good: A Report, Jessie Daniels, Polly Thistlethwaite Mar 2014

Engaging Academics And Reimagining Scholarly Communication For The Public Good: A Report, Jessie Daniels, Polly Thistlethwaite

Publications and Research

JustPublics@365 began as a discussion about how an interdisciplinary group of scholars at the Graduate Center, CUNY (located at 365 Fifth Avenue in Manhattan) might be able to bring their work together to foster greater social justice by sharing it in the public sphere.

We live in an era in which inequality is rampant. Media reports on inequality often gain little traction in a 24-hour news cycle dominated by the trivial. Activists work to address inequality in a myriad of ways, online and on the ground, but often lack connections to research or media that could further their cause. Key …


Laboratory Evaluation Of A Prospective Remediation Method For Pcb-Contaminated Paint, Erin K H Saitta, Michael J. Gittings, Christian Clausen, Jacqueline Quinn, Cherie L. Yestrebsky Mar 2014

Laboratory Evaluation Of A Prospective Remediation Method For Pcb-Contaminated Paint, Erin K H Saitta, Michael J. Gittings, Christian Clausen, Jacqueline Quinn, Cherie L. Yestrebsky

Publications and Research

Background: Paint laden with polychlorinated biphenyls (PCBs) often acts as a point source for environmental contamination. It is advantageous to address contaminated paint before the PCBs transport to surrounding media; however, current disposal methods of painted material introduce a variety of complications. Previous work demonstrates that PCBs can be broken down at ambient temperatures and pressures through a degradation process involving magnesium metal and acidified ethanol. This report is an extension of that work by describing the development of a delivery system for said reaction in preparation for a field test. Two treatment options including the Activated Metal Treatment System …


Discovering Jewish Studies Collections In Academic Libraries: A Practical Guide, Izabella Taler Mar 2014

Discovering Jewish Studies Collections In Academic Libraries: A Practical Guide, Izabella Taler

Publications and Research

The U.S. colleges and universities offering non-sectarian educational programs in Jewish Studies rely on the support of their academic libraries for research materials and library services. For college libraries which use Library of Congress Classification scheme, it is a common practice to integrate "studies" resources into their general library collections. Since Jewish Studies sources span a vast number of subjects within all major disciplines, shelving integration leads to the dispersion of all relevant sources and such dispersion in turn leads to a variety of problems for library professionals and library users. For collection development librarians the problems range from lack …


Value Of Situation Awareness Information Requirements Analysis And Information Flow Analysis, Norman E. Groner Mar 2014

Value Of Situation Awareness Information Requirements Analysis And Information Flow Analysis, Norman E. Groner

Publications and Research

No abstract provided.


Denormalizing Violence: Evaluation Framework For A Public Health Model Of Violence Prevention, Jeffrey A. Butts, Lindsay Bostwick, Jeremy Porter Mar 2014

Denormalizing Violence: Evaluation Framework For A Public Health Model Of Violence Prevention, Jeffrey A. Butts, Lindsay Bostwick, Jeremy Porter

Publications and Research

John Jay College's Research and Evaluation Center evaluated the effectiveness of the Cure Violence approach to violence reduction. Between April 2013 and February 2014, researchers began the project by visiting Cure Violence sites in New York City and Chicago, the home base for Cure Violence. The research team observed the program's operation and assessed the model's suitability for detailed evaluation. The report addresses the operations of the Cure Violence model and how it differs from other approaches for reducing gun violence. It reviews the evidence underlying these models and proposes an agenda for future evaluation research.


C. Elegans Cep-1/P53 And Bec-1 Are Involved In Dna Repair, Sandy Hoffman, Daniel Martin, Alicia Meléndez, Jill Bargonetti Feb 2014

C. Elegans Cep-1/P53 And Bec-1 Are Involved In Dna Repair, Sandy Hoffman, Daniel Martin, Alicia Meléndez, Jill Bargonetti

Publications and Research

p53 is a transcription factor that regulates the response to cellular stress. Mammalian p53 functions as a tumor suppressor. The C. elegans p53, cep-1, regulates DNA-damage induced germline cell death by activating the transcription of egl-1 and ced-13. We used the C. elegans model to investigate how, in the whole animal, different forms of DNA damage can induce p53-dependent versus p53-independent cell death and DNA repair. DNA damage was induced by ultraviolet type C (UVC) radiation, or 10-decarbamoyl mitomycin C (DMC, an agent known to induce mammalian p53-independent cell death). Wild-type or cep-1 loss-of-function mutant animals were assayed for germline …


Disassembly Of The Cystovirus Φ6 Envelope By Montmorillonite Clay, Karin A. Block, Adrianna Trusiak, Al Katz, Paul Gottlieb, Alexandra Alimova, Hui Wei, Jorge Morales, William J. Rice, Jeffrey C. Steiner Feb 2014

Disassembly Of The Cystovirus Φ6 Envelope By Montmorillonite Clay, Karin A. Block, Adrianna Trusiak, Al Katz, Paul Gottlieb, Alexandra Alimova, Hui Wei, Jorge Morales, William J. Rice, Jeffrey C. Steiner

Publications and Research

Prior studies of clay–virus interactions have focused on the stability and infectivity of nonenveloped viruses, yielding contradictory results. We hypothesize that the surface charge distribution of the clay and virus envelope dictates how the components react and affect aggregation, viral stability, and infectivity. The bacteriophage Cystoviridae species φ6 used in this study is a good model for enveloped pathogens. The interaction between φ6 and montmorillonite (MMT) clay (the primary component of bentonite) is explored by transmission electron microscopy. The analyses show that MMT–φ6 mixtures undergo heteroaggregation, forming structures in which virtually all the virions are either sequestered between MMT platelet …


Strategies To Reduce The Harmful Effects Of Extreme Heat Events: A Four-City Study, Jalonne L. White-Newsome, Sabrina Mccormick, Natalie Sampson, Miatta A. Buxton, Marie S. O’Neill, Carina J. Gronlund, Linda Catalano, Kathryn C. Conlon, Edith A. Parker Feb 2014

Strategies To Reduce The Harmful Effects Of Extreme Heat Events: A Four-City Study, Jalonne L. White-Newsome, Sabrina Mccormick, Natalie Sampson, Miatta A. Buxton, Marie S. O’Neill, Carina J. Gronlund, Linda Catalano, Kathryn C. Conlon, Edith A. Parker

Publications and Research

Extreme heat events (EHEs) are becoming more intense, more frequent and longer lasting in the 21st century. These events can disproportionately impact the health of low-income, minority, and urban populations. To better understand heat-related intervention strategies used by four U.S. cities, we conducted 73 semi-structured interviews with government and non-governmental organization leaders representing public health, general social services, emergency management, meteorology, and the environmental planning sectors in Detroit, MI; New York City, NY; Philadelphia, PA and Phoenix, AZ—cities selected for their diverse demographics, climates, and climate adaptation strategies. We identified activities these leaders used to reduce the harmful effects of …


A Review Of Air–Ice Chemical And Physical Interactions (Aici): Liquids, Quasi-Liquids, And Solids In Snow, T. Bartels-Rausch, H-W Jacobi, T. F. Kahan, J. L. Thomas, E. S. Thomson, J. P. D. Abbatt, M. Ammann, J. R. Blackford, H. Bluhm, Chris Boxe, F. Domine, M. M. Frey, I. Gladich, M. I. Guzmán, D. Heger, Th. Huthwelker, P. Klán, W. F. Kuhs, M. H. Kuo, S. Maus, S. G. Moussa, V. F. Mcneill, J. T. Newberg, J. B. C. Pettersson, M. Roeselová, J. R. Sodeau Feb 2014

A Review Of Air–Ice Chemical And Physical Interactions (Aici): Liquids, Quasi-Liquids, And Solids In Snow, T. Bartels-Rausch, H-W Jacobi, T. F. Kahan, J. L. Thomas, E. S. Thomson, J. P. D. Abbatt, M. Ammann, J. R. Blackford, H. Bluhm, Chris Boxe, F. Domine, M. M. Frey, I. Gladich, M. I. Guzmán, D. Heger, Th. Huthwelker, P. Klán, W. F. Kuhs, M. H. Kuo, S. Maus, S. G. Moussa, V. F. Mcneill, J. T. Newberg, J. B. C. Pettersson, M. Roeselová, J. R. Sodeau

Publications and Research

Snow in the environment acts as a host to rich chemistry and provides a matrix for physical exchange of contaminants within the ecosystem. The goal of this review is to summarise the current state of knowledge of physical processes and chemical reactivity in surface snow with relevance to polar regions. It focuses on a description of impurities in distinct compartments present in surface snow, such as snow crystals, grain boundaries, crystal surfaces, and liquid parts. It emphasises the microscopic description of the ice surface and its link with the environment. Distinct differences between the disordered air–ice interface, often termed quasi-liquid …


Big Data Analytics In Healthcare: Promise And Potential, Wullianallur Raghupathi, Viju Raghupathi Feb 2014

Big Data Analytics In Healthcare: Promise And Potential, Wullianallur Raghupathi, Viju Raghupathi

Publications and Research

Objective To describe the promise and potential of big data analytics in healthcare.

Methods The paper describes the nascent field of big data analytics in healthcare, discusses the benefits, outlines an architectural framework and methodology, describes examples reported in the literature, briefly discusses the challenges, and offers conclusions.

Results The paper provides a broad overview of big data analytics for healthcare researchers and practitioners.

Conclusions Big data analytics in healthcare is evolving into a promising field for providing insight from very large data sets and improving outcomes while reducing costs. Its potential is great; however there remain challenges to overcome.


Narratives Of Violence: The White Imagination And The Making Of Black Masculinity In “City Of God”, Jaime Alves Feb 2014

Narratives Of Violence: The White Imagination And The Making Of Black Masculinity In “City Of God”, Jaime Alves

Publications and Research

The article explores the representation of young-black men in the 2002 film City of God. The film deploys “pathological scripts” of Black masculinity in Brazil as criminal and deviant. The controlling image of Black men’s bodies as a source of danger and impurity sustains Brazilian regime of racial domination, and the narratives of violence make explicit the ways in which the Brazilian nation is imagined though a racial underpinning. Blackness is consumed as an exotic commodity, yet is also understood as a threat to national harmony. The nation is, then, written and re-imagined as a racial paradise, but mostly by …


Cyclic Phosphonium Ionic Liquids, Sharon I. Lall-Ramnarine, Joshua A. Mukhlall, James F. Wishart, Robert R. Engel, Alicia R. Romeo, Masao Gohdo, Sharon Ramati, Marc B. Berman, Sophia N. Suarez Jan 2014

Cyclic Phosphonium Ionic Liquids, Sharon I. Lall-Ramnarine, Joshua A. Mukhlall, James F. Wishart, Robert R. Engel, Alicia R. Romeo, Masao Gohdo, Sharon Ramati, Marc B. Berman, Sophia N. Suarez

Publications and Research

Ionic liquids (ILs) incorporating cyclic phosphonium cations are a novel category of materials. We report here on the synthesis and characterization of four new cyclic phosphonium bis(trifluoromethylsulfonyl)amide ILs with aliphatic and aromatic pendant groups. In addition to the syntheses of these novel materials, we report on a comparison of their properties with their ammonium congeners. These exemplars are slightly less conductive and have slightly smaller self-diffusion coefficients than their cyclic ammonium congeners.


Peptide Detection Of Fungal Functional Amyloids In Infected Tissue, Melissa C. Garcia-Sherman, Nataliya Lysak, Alexandra Filonenko, Hazel Richards, Richard E. Sobonya, Stephen A. Klotz, Peter N. Lipke Jan 2014

Peptide Detection Of Fungal Functional Amyloids In Infected Tissue, Melissa C. Garcia-Sherman, Nataliya Lysak, Alexandra Filonenko, Hazel Richards, Richard E. Sobonya, Stephen A. Klotz, Peter N. Lipke

Publications and Research

Many fungal cell adhesion proteins form functional amyloid patches on the surface of adhering cells. The Candida albicans Agglutinin-like sequence (Als) adhesins are exemplars for this phenomenon, and have amyloid forming sequences that are conserved between family members. The Als5p amyloid sequence mediates amyloid fibril formation and is critical for cell adhesion and biofilm formation, and is also present in the related adhesins Als1p and Als3p. We have developed a fluorescent peptide probe containing the conserved Als amyloid-forming sequence. This peptide bound specifically to yeast expressing Als5p, but not to cells lacking the adhesin. The probe bound to both yeast …


Inhibition Of Extracellular Hmgb1 Attenuates Hyperoxia-Induced Inflammatory Acute Lung Injury, Maria Entezari, Mohammad Javdan, Daniel J. Antoine, Dympna M.P. Morrow, Ravikumar A. Sitapara, Vivek Patel, Mao Wang, Lokesh Sharma, Samir Gorasiya, Michelle Zur, Wenjun Wu, Jianhua Li, Huan Yang, Charles R. Ashby, Douglas Thomas, Haichao Wang, Lin L. Mantell Jan 2014

Inhibition Of Extracellular Hmgb1 Attenuates Hyperoxia-Induced Inflammatory Acute Lung Injury, Maria Entezari, Mohammad Javdan, Daniel J. Antoine, Dympna M.P. Morrow, Ravikumar A. Sitapara, Vivek Patel, Mao Wang, Lokesh Sharma, Samir Gorasiya, Michelle Zur, Wenjun Wu, Jianhua Li, Huan Yang, Charles R. Ashby, Douglas Thomas, Haichao Wang, Lin L. Mantell

Publications and Research

Prolonged exposure to hyperoxia results in acute lung injury (ALI), accompanied by a significant elevation in the levels of proinflammatory cytokines and leukocyte infiltration in the lungs. However, the mechanisms underlying hyperoxia-induced proinflammatory ALI remain to be elucidated. In this study, we investigated the role of the proinflammatory cytokine high mobility group box protein 1 (HMGB1) in hyperoxic inflammatory lung injury, using an adult mouse model. The exposure of C57BL/6 mice to ≥99% O2 (hyperoxia) significantly increased the accumulation of HMGB1 in the bronchoalveolar lavage fluids (BALF) prior to the onset of severe inflammatory lung injury. In the airways of …


The Adaptive Remodeling Of Endothelial Glycocalyx In Response To Fluid Shear Stress, Ye Zeng, John M. Tarbell Jan 2014

The Adaptive Remodeling Of Endothelial Glycocalyx In Response To Fluid Shear Stress, Ye Zeng, John M. Tarbell

Publications and Research

The endothelial glycocalyx is vital for mechanotransduction and endothelial barrier integrity. We previously demonstrated the early changes in glycocalyx organization during the initial 30 min of shear exposure. In the present study, we tested the hypothesis that long-term shear stress induces further remodeling of the glycocalyx resulting in a robust layer, and explored the responses of membrane rafts and the actin cytoskeleton. After exposure to shear stress for 24 h, the glycocalyx components heparan sulfate, chondroitin sulfate, glypican-1 and syndecan-1, were enhanced on the apical surface, with nearly uniform spatial distributions close to baseline levels that differed greatly from the …


Seasonal Mesophotic Coral Bleaching Of Stylophora Pistillata In The Northern Red Sea, Orit Nir, David F. Gruber, Eli Shemesh, Eliezra Glasser, Dan Tchernov Jan 2014

Seasonal Mesophotic Coral Bleaching Of Stylophora Pistillata In The Northern Red Sea, Orit Nir, David F. Gruber, Eli Shemesh, Eliezra Glasser, Dan Tchernov

Publications and Research

Coral bleaching occurs when environmental stress induces breakdown of the coral-algae symbiosis and the host initiates algae expulsion. Two types of coral bleaching had been thoroughly discussed in the scientific literature; the first is primarily associated with mass coral bleaching events; the second is a seasonal loss of algae and/or pigments. Here, we describe a phenomenon that has been witnessed for repeated summers in the mesophotic zone (40–63 m) in the northern Red Sea: seasonal bleaching and recovery of several hermatypic coral species. In this study, we followed the recurring bleaching process of the common coral Stylophora pistillata. Bleaching occurred …