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Articles 1261 - 1290 of 3084
Full-Text Articles in Entire DC Network
Target Engagement Imaging Of Parp Inhibitors In Small-Cell Lung Cancer, Brandon Carney, Susanne Kossatz, Benjamin H. Lok, Valentina Schneeberger, Kishore K. Gangangari, Naga Vara Kishore Pillarsetty, Wolfgang A. Weber, Charles M. Rudin, John T. Poirier, Thomas Reiner
Target Engagement Imaging Of Parp Inhibitors In Small-Cell Lung Cancer, Brandon Carney, Susanne Kossatz, Benjamin H. Lok, Valentina Schneeberger, Kishore K. Gangangari, Naga Vara Kishore Pillarsetty, Wolfgang A. Weber, Charles M. Rudin, John T. Poirier, Thomas Reiner
Publications and Research
Insufficient chemotherapy response and rapid disease progression remain concerns for smallcell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment decisions, but this cannot assess in vivo target engagement of therapeutic agents. Biomarker assessments in biopsy material do not assess contemporaneous target expression, intratumoral drug exposure, or drug-target engagement. Here, we report the use of PARP1/2-targeted imaging to measure target engagement of PARP inhibitors in vivo. Using a panel of clinical PARP inhibitors, we show that PARP imaging can quantify target engagement of chemically diverse small molecule inhibitors in vitro and in vivo. We measure PARP1/2 inhibition …
The Variability Of Neural Responses To Naturalistic Videos Change With Age And Sex, Agustin Petroni, Samantha Cohen, Lei Ai, Nicolas Langer, Simon Henin, Tamara Vanderwal, Michael P. Milham, Lucas C. Parra
The Variability Of Neural Responses To Naturalistic Videos Change With Age And Sex, Agustin Petroni, Samantha Cohen, Lei Ai, Nicolas Langer, Simon Henin, Tamara Vanderwal, Michael P. Milham, Lucas C. Parra
Publications and Research
Neural development is generally marked by an increase in the efficiency and diversity of neural processes. In a large sample (n=114) of human children and adults with ages ranging from 5 to 44 yr, we investigated the neural responses to naturalistic video stimuli. Videos from both real-life classroom settings and Hollywood feature films were used to probe different aspects of attention and engagement. For all stimuli, older ages were marked by more variable neural responses. Variability was assessed by the intersubject correlation of evoked electroencephalographic responses. Young males also had less-variable responses than young females. These results were replicated in …
Cooperative Standing-Horizontalstanding Reentrant Transition For Numerous Solid Particles Under External Vibration, Satoshi Takatori, Hikari Baba, Takatoshi Ichino, Chwen-Yang Shew, Kenichi Yoshikawa
Cooperative Standing-Horizontalstanding Reentrant Transition For Numerous Solid Particles Under External Vibration, Satoshi Takatori, Hikari Baba, Takatoshi Ichino, Chwen-Yang Shew, Kenichi Yoshikawa
Publications and Research
We report the collective behavior of numerous plastic bolt-like particles exhibiting one of two distinct states, either standing stationary or horizontal accompanied by tumbling motion, when placed on a horizontal plate undergoing sinusoidal vertical vibration. Experimentally, we prepared an initial state in which all of the particles were standing except for a single particle that was placed at the center of the plate. Under continuous vertical vibration, the initially horizontal particle triggers neighboring particles to fall over into a horizontal state through tumbling-induced collision, and this effect gradually spreads to all of the particles, i.e., the number of horizontal particles …
Strains Of Bacterial Species Induce A Greatly Varied Acute Adaptive Immune Response: The Contribution Of The Accessory Genome, Uri Sela, Chad W. Euler, Joel Correa Da Rosa, Vincent A. Fischetti
Strains Of Bacterial Species Induce A Greatly Varied Acute Adaptive Immune Response: The Contribution Of The Accessory Genome, Uri Sela, Chad W. Euler, Joel Correa Da Rosa, Vincent A. Fischetti
Publications and Research
A fundamental question in human susceptibility to bacterial infections is to what extent variability is a function of differences in the pathogen species or in individual humans. To focus on the pathogen species, we compared in the same individual the human adaptive T and B cell immune response to multiple strains of two major human pathogens, Staphylococcus aureus and Streptococcus pyogenes. We found wide variability in the acute adaptive immune response induced by various strains of a species, with a unique combination of activation within the two arms of the adaptive response. Further, this was also accompanied by a dramatic …
The Microbe Directory: An Annotated, Searchable Inventory Of Microbes’ Characteristics, Heba Shaaban, David A. Westfall, Rawhi Mohammad, David Danko, Daniela Bezdan, Ebrahim Afshinnekoo, Nicola Segata, Christopher E. Mason
The Microbe Directory: An Annotated, Searchable Inventory Of Microbes’ Characteristics, Heba Shaaban, David A. Westfall, Rawhi Mohammad, David Danko, Daniela Bezdan, Ebrahim Afshinnekoo, Nicola Segata, Christopher E. Mason
Publications and Research
The Microbe Directory is a collective research effort to profile and annotate more than 7,500 unique microbial species from the MetaPhlAn2 database that includes bacteria, archaea, viruses, fungi, and protozoa. By collecting and summarizing data on various microbes’ characteristics, the project comprises a database that can be used downstream of large-scale metagenomic taxonomic analyses, allowing one to interpret and explore their taxonomic classifications to have a deeper understanding of the microbial ecosystem they are studying. Such characteristics include, but are not limited to: optimal pH, optimal temperature, Gram stain, biofilm-formation, spore-formation, antimicrobial resistance, and COGEM class risk rating. The database …
Component Tree Analysis Of Cystovirus Φ6 Nucleocapsid Cryo-Em Single Particle Reconstructions, Lucas Oliveira, Ze Ye, Al Katz, Alexandra Alimova, Hui Wei, Gabor T. Herman, Paul Gottlieb
Component Tree Analysis Of Cystovirus Φ6 Nucleocapsid Cryo-Em Single Particle Reconstructions, Lucas Oliveira, Ze Ye, Al Katz, Alexandra Alimova, Hui Wei, Gabor T. Herman, Paul Gottlieb
Publications and Research
The 3-dimensional structure of the nucleocapsid (NC) of bacteriophage φ6 is described utilizing component tree analysis, a topological and geometric image descriptor. The component trees are derived from density maps of cryo-electron microscopy single particle reconstructions. Analysis determines position and occupancy of structure elements responsible for RNA packaging and transcription. Occupancy of the hexameric nucleotide triphosphorylase (P4) and RNA polymerase (P2) are found to be essentially complete in the NC. The P8 protein lattice likely fixes P4 and P2 in place during maturation. We propose that the viral procapsid (PC) is a dynamic structural intermediate where the P4 and P2 …
The Rise Of Advocacy Satire, Don Waisanen
The Rise Of Advocacy Satire, Don Waisanen
Publications and Research
No abstract provided.
Introduction: Polipolitical Conversion: Personal Transformation As Strategic Public Communication (Introduction)Tical Transformation As A Pervasive Strategy, Don Waisanen
Publications and Research
No abstract provided.
Touching Queerness In Disney Films Dumbo And Lilo & Stitch, Katia Perea
Touching Queerness In Disney Films Dumbo And Lilo & Stitch, Katia Perea
Publications and Research
Disney’s influence as a cultural purveyor is difficult to overstate. From cinema screen to television programming, vacation theme parks to wardrobe, toys and books, Disney’s consistent ability to entertain children as well as adults has made it a mainstay of popular culture. This research will look at two Disney films, Dumbo (1941) and Lilo & Stitch (2002), both from distinctly different eras, and analyze the similarities in artistic styling, studio financial climate, and their narrative representation of otherness as it relates to Queer identity.
Institutional Theory And The History Of District-Level School Reform: A Reintroduction, Judith R. Kafka
Institutional Theory And The History Of District-Level School Reform: A Reintroduction, Judith R. Kafka
Publications and Research
In this chapter I make my case for the utility of institutionalism for historians of education, first by explaining institutional theory and how it has been applied to, and shaped by, the study of schooling, and then by applying new theoretical developments to district-level historical research using examples drawn from earlier chapters in this volume. Ultimately, institutional theory may help us to interrogate Tyack and Cuban’s notion of institutional change in schools, by elaborating on their construction of the change process through specific, embedded, settings, and by rethinking how we determine what “counts” as change in schools and districts.
Using Visual “Bait” To Hook, Engage, And Empower New Community College Writers, Nicola Blake
Using Visual “Bait” To Hook, Engage, And Empower New Community College Writers, Nicola Blake
Publications and Research
This reflective article focuses on a series of semester-long activities conducted with developmental writers in an urban community college classroom. It builds on the research of John Berger (1972) and Sondra Perl (1994) who highlight seeing and perception as key components of self-composition. The article showcases assignments where students created photo journals as a way to share their lives, thoughts, and experiences. The use of structured prompts allowed students to actively engage with their neighborhoods -- a sort of text to be read, captured, and ultimately decoded through written explanation. The examples will be useful to practitioners who may be …
Religion On The Dance Floor: Afro-Dominican Music And Ritual From Altars To Clubs, Angelina M. Tallaj
Religion On The Dance Floor: Afro-Dominican Music And Ritual From Altars To Clubs, Angelina M. Tallaj
Publications and Research
In this essay, I examine the current New York scene and the emerging discourses surrounding the recent visibility of Dominican Voodoo (Vudú) and its music. When Dominicans migrated, they brought with them these marginalized genres of music including the music of Vudú, and, since the 2000s, this music (palo) has moved from the religious arena to the popular music world, in turn changing the nature of the religious rituals. In New York City, Vudú ceremonies can now publicly feature drumming and possession and are practiced in commercial venues rather than in private homes and altar spaces. While this move of …
The Relationship Between In-Session Commitment Language And Daily Self-Reported Commitment To Reduce Or Abstain From Drinking, Alexis Kuerbis, Jessica Houser, Paul Amrhein, Hayley Treloar Padovano, Jon Morgenstern
The Relationship Between In-Session Commitment Language And Daily Self-Reported Commitment To Reduce Or Abstain From Drinking, Alexis Kuerbis, Jessica Houser, Paul Amrhein, Hayley Treloar Padovano, Jon Morgenstern
Publications and Research
Background: Motivational interviewing is hypothesized to operate by enhancing a client’s internal motivation to change. Past research operationalizes this process by measuring in-session statements for change (i.e., change talk), yet relationships between change talk and other measures of motivation have yet to be substantiated. This study tested whether in-session change talk predicted subsequent reports of commitment to abstain or moderate drinking assessed via ecological momentary assessment (EMA), and explored each of their contributions to drinking outcomes. Method: Secondary data analysis was performed on data from 48 study participants who received therapy within a randomized controlled trial testing mechanisms of actions …
What We Mean When We Talk About Reading: Rethinking The Purposes And Contexts Of College Reading, Rachel Ihara, Ann Del Principe
What We Mean When We Talk About Reading: Rethinking The Purposes And Contexts Of College Reading, Rachel Ihara, Ann Del Principe
Publications and Research
This study illuminates faculty beliefs about reading by closely examining their attitudes toward assigned readings and faculty professional reading practice. Drawing upon interview data from instructors teaching in a range of disciplines at a two-year college, we suggest that conversations about reading would benefit from greater awareness of the various contexts and purposes for reading. Rather than talk about reading as something students either "do" or "don’t do", or do well or poorly, we draw attention to the ways that different purposes for reading shape reading behaviors for students and faculty alike.
In-Terracial Conversation, Cheryl Dunye, Alexandra Juhasz
In-Terracial Conversation, Cheryl Dunye, Alexandra Juhasz
Publications and Research
No abstract provided.
Who Speaks For The Paralegal Studies Student? - An Educator’S Perspective When Teaching Forensic Science To The Legal Studies Student, Marissa Moran
Who Speaks For The Paralegal Studies Student? - An Educator’S Perspective When Teaching Forensic Science To The Legal Studies Student, Marissa Moran
Publications and Research
No abstract provided.
Black Detroit: The Worst Nightmare Of The American Establishment: Interview With Dan Georgakas, Despina Lalaki
Black Detroit: The Worst Nightmare Of The American Establishment: Interview With Dan Georgakas, Despina Lalaki
Publications and Research
No abstract provided.
Peptide Density Targets And Impedes Triple Negative Breast Cancer Metastasis, Daxing Liu, Peng Guo, Craig Mccarthy, Biran Wang, Yu Tao, Debra Auguste
Peptide Density Targets And Impedes Triple Negative Breast Cancer Metastasis, Daxing Liu, Peng Guo, Craig Mccarthy, Biran Wang, Yu Tao, Debra Auguste
Publications and Research
The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are dependent on single molecule-receptor interactions or silencing CXCR4 expression. CXCR4 localizes in lipid rafts and forms dimers therefore CXCR4 targeting and signaling may depend on ligand density. Herein, we report liposomes presenting a CXCR4 binding peptide (DV1) as a threedimensional molecular array, ranging from 9k to 74k molecules μm−2, target triple negative breast cancer (TNBC). TNBC cells exhibit a maxima in binding and uptake of DV1functionalized liposomes (L-DV1) in vitro at a specific density, which yields a …
The Library Leading: Knowledge Management Supporting Community College Institutional Strategy, Elizabeth Jardine
The Library Leading: Knowledge Management Supporting Community College Institutional Strategy, Elizabeth Jardine
Publications and Research
This case study demonstrates how librarians at LaGuardia Community College led a college-wide knowledge management project to implement Ask LaGuardia, an online knowledge base where users can find answers to common questions on navigating this large, urban college. Students had been experiencing difficulty receiving clear, correct, and consistent answers to their questions while staff had been challenged by information silos. LaGuardia’s president chose the Library for a leadership role in this initiative supporting a broader strategy of better alignment between Academic and Student Affairs. The Library’s positive reputation and knowledge organization expertise made it a natural fit. Four years in, …
Kratylos: A Tool For Sharing Interlinearized And Lexical Data In Diverse Formats, Daniel Kaufman, Raphael Finkel
Kratylos: A Tool For Sharing Interlinearized And Lexical Data In Diverse Formats, Daniel Kaufman, Raphael Finkel
Publications and Research
In this paper we present Kratylos, at www.kratylos.org/, a web application that creates searchable multimedia corpora from data collections in diverse formats, including collections of interlinearized glossed text (IGT) and dictionaries. There exists a crucial lacuna in the electronic ecology that supports language documentation and linguistic research. Vast amounts of IGT are produced in stand-alone programs without an easy way to share them publicly as dynamic databases. Solving this problem will not only unlock an enormous amount of linguistic information that can be shared easily across the web, it will also improve accountability by allowing us to verify analyses across …
Vicarious Retribution In U.S. Public Support For War Against Iraq, Peter Liberman, Linda J. Skitka
Vicarious Retribution In U.S. Public Support For War Against Iraq, Peter Liberman, Linda J. Skitka
Publications and Research
U.S. public anger and desires to avenge the 11 September 2001 terror attacks were redirected toward Iraq partly because of its identity as an Arab and Muslim state. Online panel survey data reveal that citizens who were relatively angry about the terror attacks were more belligerent toward Iraq, and that this effect was strongest among those who perceived Arabs and Muslims in monolithic terms. Angry desires to avenge 9/11 were more persistent for those who saw Arabs and Muslims in that light, and their effects on war support were partially mediated by worsened feelings about Arabs and Muslims in general. …
“‘The Most Fabricated Exception’: Islam, Immigration And The White-Saviour Narrative In Laurent Cantet’S The Class.”, Elizabeth Toohey
“‘The Most Fabricated Exception’: Islam, Immigration And The White-Saviour Narrative In Laurent Cantet’S The Class.”, Elizabeth Toohey
Publications and Research
This article suggests that the acclaim director Laurent Cantet received for his 2008 award winning film “The Class” obscures the way this film reinforces the very undercurrents in French culture he sets out to critique. Rather than unearthing or mirroring the racial dynamics of twenty-first-century Paris, Cantet brings to the film a set of fascinations and anxieties latent in the French imagination about blackness, Islam and Arab culture. His preoccupations and preconceptions with race, religion and nationality appear first in the portrayal of Muslim immigrants as threatening; next, in his image of a ‘white saviour’ bent on rescuing racial minorities; …
Remembering Vancouver’S Disappeared Women: Settler Colonialism And The Difficulty Of Inheritance, Gordon Alley-Young
Remembering Vancouver’S Disappeared Women: Settler Colonialism And The Difficulty Of Inheritance, Gordon Alley-Young
Publications and Research
No abstract provided.
Considering Ethical Questions In (Non)Fiction: Reading And Writing About Graphic Novels, Gene Mcquillan
Considering Ethical Questions In (Non)Fiction: Reading And Writing About Graphic Novels, Gene Mcquillan
Publications and Research
No abstract provided.
Media Coverage Of Human Rights In The Us And Uk: The Violations Still Won’T Be Televised (Or Published), Shawna M. Brandle
Media Coverage Of Human Rights In The Us And Uk: The Violations Still Won’T Be Televised (Or Published), Shawna M. Brandle
Publications and Research
This article analyzes American television and American and British print news coverage of human rights using a combination of manual and machine coding. The data reveal that television and print news cover very few human rights stories, that these stories are mostly international and not domestic, that even when human rights are covered, they are not covered in detail, and that human rights issues are more likely to be covered when they are not framed as human rights. This suggests that human rights is simply not a frame that journalists employ, and provides support for government-leading-media theories of newsworthiness.
Emancipatory Learning, Open Educational Resources, Open Education, And Digital Critical Participatory Action Research, Jason Leggett, Jay Wen, Anthony Chatman
Emancipatory Learning, Open Educational Resources, Open Education, And Digital Critical Participatory Action Research, Jason Leggett, Jay Wen, Anthony Chatman
Publications and Research
Given that we must prepare students for the future workforce today how can we use the power of Open Educational Resources (OERs) and Digital Social Science research to improve student learning and help students develop technical skills needed for the high-tech workforce? In this article, we use transformative learning theory (Mezirow, 1978) and Digital + Critical Participatory Action Research (D+CPAR) to analyze the effectiveness of integrating OERs into a course and reflect on how we used OERs to support student learning and make civic engagement more equitable at an urban community college. In a criminal justice course analyzing the legal …
Who Are The Stewards Of The Aids Archive?, Alexandra Juhasz, Theodore Kerr
Who Are The Stewards Of The Aids Archive?, Alexandra Juhasz, Theodore Kerr
Publications and Research
How are returns to AIDS cultural production whitewashed, and how can we return, attending with care to the earlier video work of women and people of color. How can we practice decent stewardship of this vulerbale archive?
#Cut/Paste+Bleed: Entangling Feminist Affect, Action And Production On And Offline, Alexandra Juhasz
#Cut/Paste+Bleed: Entangling Feminist Affect, Action And Production On And Offline, Alexandra Juhasz
Publications and Research
I consider my media praxis project to be labs, encounters, theory-making and scholarly output where doing and thinking in community (often the classroom and its linked spaces) in the sites or technologies under consideration is the “scholarly” product. That is to say, the doing and the process is the product, and what remains can also be shared and/or evaluated, as needed. This sharing of process is what I model now. I describe my most recent project, Ev-Ent-Anglement, engaging again critically with social media networks from inside them, share some of my lessons learned about production and action-based New Media/DH research, …
Evolution Of Western Library Catalogs: The Rising Expectations Of Users, Junli Diao
Evolution Of Western Library Catalogs: The Rising Expectations Of Users, Junli Diao
Publications and Research
This paper traces the historical development of library catalogs from primitive catalogs in ancient times to current next generational catalogs, which are summarized into three stages: the agricultural catalog stage, the industrial catalog stage and the information catalog stage. In particular, this paper focuses on the discussion of the rise of users’ expectations on library catalogs at different stages and gives emphasis to what impact they have created accordingly.
Conceptualizations Of Catalogers’ Judgment Through Content Analysis: A Preliminary Investigation, Junli Diao
Conceptualizations Of Catalogers’ Judgment Through Content Analysis: A Preliminary Investigation, Junli Diao
Publications and Research
Catalogers’ judgment is frequently mentioned, but rarely researched in formal studies. The purpose of this article is to investigate catalogers’ judgment through an exploration of the texts collected in the database of Library and Information Science Source. Verbs, adjectives and nouns intimately associated with catalogers’ judgment were extracted, analyzed and grouped into 16 categories, which give birth to five conceptual descriptions. The results of this study provide cataloging professionals with an overview picture on aspects of catalogers’ judgment. They may help library school students and graduates and novice catalogers to become independent and confident decision makers relating to cataloging work.