Digital Commons Network^™

Continuing The Gender Equity In Academia Conversation: Recommendations And Next Steps, Maria J. D'Agostino, Nicole Elias

Publications and Research

No abstract provided.

Mixed News About Youth Violence In Recent Fbi Crime Data, Jeffrey A. Butts

Publications and Research

FBI crime data displayed a slight increase in violent crime rates between 2016 and 2017. Media reports on this variation did not always mention that violent crime rates are still near a 35-year low. This databit shows the rates of youth arrested for violent crimes between 1982 and 2017.

Griffithsin Carrageenan Fast Dissolving Inserts Prevent Shiv Hsv-2 And Hpv Infections In Vivo, Nina Derby, Manjari Lal, Meropi Aravatinou, Larisa Kizima, Patrick Barnable, Axia Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R. O'Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José Fernández-Romero, Thomas M. Zydowsky

Publications and Research

Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected. Moreover, ondemand products are currently missing from the PrEP development portfolio. Griffithsin (GRFT) is a non-antiretroviral HIV entry inhibitor derived from red algae with an excellent safety profile and potent activity in vitro. When combined with carrageenan (CG), GRFT has strong activity against herpes simplex virus-2 (HSV-2) and human papillomavirus (HPV) in vitro and in vivo. Here, we report that GRFT/CG in a freeze-dried fast dissolving insert (FDI) …

A Tool For Optimizing Java 8 Stream Software Via Automated Refactoring, Raffi Khatchadourian, Yiming Tang, Mehdi Bagherzadeh, Syed Ahmed

Publications and Research

Streaming APIs are pervasive in mainstream Object-Oriented languages. For example, the Java 8 Stream API allows for functional-like, MapReduce-style operations in processing both finite and infinite data structures. However, using this API efficiently involves subtle considerations like determining when it is best for stream operations to run in parallel, when running operations in parallel can be less efficient, and when it is safe to run in parallel due to possible lambda expression side-effects. In this paper, we describe the engineering aspects of an open source automated refactoring tool called Optimize Streams that assists developers in writing optimal stream software in …

W.E.B. Dubois For The Twenty‐First Century: On Being A Scholar‐Activist In The Digital Era, Jessie Daniels

Publications and Research

W.E.B. Du Bois began his work as a scholar-activist at the dawn of the twentieth century, and this paper argues that his example has much to teach contemporary scholar-activists in the twenty-first century. In order to publish The Crisis, the magazine of the activist organization he co-founded, DuBois purchased a printing press. This meant he could own the means of his own knowledge production and foretold both the promise of what it means to be a scholar-activist in the twenty-first century and the limitations built into the current systems of knowledge production. Du Bois was also prophetic when he …

Testing A Web-Based Interactive Comic Tool To Decrease Obesity Risk Among Minority Preadolescents: Protocol For A Pilot Randomized Control Trial, May May Leung, Katrina F. Mateo, Sandra Verdaguer, Katarzyna Wyka

Publications and Research

Background: Childhood obesity is a public health crisis, particularly in low-income, minority populations in the United States. Innovative and technology-enhanced interventions may be an engaging approach to reach at-risk youth and their parents to improve dietary behaviors and feeding practices. However, such tools are limited, especially ones that are theory-based; co-developed with user-centered approaches; tailored to low-income, minority preadolescents; and include parent-focused content.

Objective: The objectives of this study include assessing the feasibility and acceptability and exploring the potential impact of the Intervention INC (Interactive Nutrition Comics for urban, minority preadolescents) Web-based tool, which is focused on decreasing childhood obesity …

Maternal Experiences Of Intimate Partner Violence And C-Reactive Protein Levels In Young Children In Tanzania, Natalie Slopen, Jing Zhang, Samuel S. Urlacher, Gretchen De Silva, Mona Mittal

Publications and Research

Intimate partner violence (IPV) is a critical public health issue that impacts women and children across the globe.Prior studies have documented that maternal experiences of IPV are associated with adverse psychological and physical health outcomes in children; however, research on the underlying physiological pathways linking IPV to these conditions is limited. Drawing on data from the 2010 Tanzania Demographic and Health Survey, we examined the relationship between maternal report of IPV in the past 12 months and inflammation among children ages 6 months to 5 years. Our study included 503 children who were randomly selected to provide a blood sample …

Rapid, Field-Deployable Method For Collecting And Preserving Plant Metabolome For Biochemical And Functional Characterization, Sarah A. Skubel, Vyacheslav Dushenkov, Brittany L. Graf, Qingwei Niu, Alexander Poulev, Hetalben Kalariya, Llewellyn C. Foxcroft, Ilya Raskin

Publications and Research

Study of plant metabolome is a growing field of science that catalogs vast biochemical and functional diversity of phytochemicals. However, collecting and storing samples of plant metabolome, sharing these samples across the scientific community and making them compatible with bioactivity assays presents significant challenges to the advancement of metabolome research. We have developed a RApid Metabolome Extraction and Storage (RAMES) technology that allows efficient, highly compact, field-deployable collection and storage of libraries of plant metabolome. RAMES technology combines rapid extraction with immobilization of extracts on glass microfiber filter discs. Two grams of plant tissue extracted in ethanol, using a specially …

The Politics Of Apolitical Culture. The Cia And The Congress Of Cultural Freedom, Despina Lalaki

Publications and Research

No abstract provided.

Idrissa Ouedraogo, The Maestro Of Burkina Cinema, Boukary Sawadogo

Publications and Research

No abstract provided.

Sex And The Single Feminist Science Fiction Scholar, Marleen S. Barr

Publications and Research

In the AAUP magazine ACADEME, feminist science fiction scholar Marleen S. Barr discusses her past in light of #MeToo.

Crafting A Research Question: Differentiated Teaching For Instruction With Primary Sources Across Diverse Learning Levels, Jen Hoyer, Kaitlin Holt, Julia Pelaez

Publications and Research

This case study illustrates methods for drawing on primary sources to instruct students on how to generate and refine research questions (Guidelines for Primary Source Literacy, learning objective 1C) and to recognize that research questions may change (Guidelines for Primary Source Literacy, learning objective 1D). The authors are educators with the Brooklyn Connections program, the school outreach arm of Brooklyn Public Library’s archive and rare book division. Given the diversity of the students served by this program, this case study focuses on adapting a lesson to three examples of lesson implementation, one each in elementary, middle, and high school, varyingly …

Nano And Microsensors For Mammalian Cell Studies, Ioana Voiculescu, Masaya Toda, Naoki Inomata, Takahito Ono, Fang Li

Publications and Research

This review presents several sensors with dimensions at the nano- and micro-scale used for biological applications. Two types of cantilever beams employed as highly sensitive temperature sensors with biological applications will be presented. One type of cantilever beam is fabricated from composite materials and is operated in the deflection mode. In order to achieve the high sensitivity required for detection of heat generated by a single mammalian cell, the cantilever beam temperature sensor presented in this review was microprocessed with a length at the microscale and a thickness in the nanoscale dimension. The second type of cantilever beam presented in …

Leveraging Pet To Image Folate Receptor Α Therapy Of An Antibody-Drug Conjugate, Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangagari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Joseph A. Konner, Thomas Reiner

Publications and Research

Background: The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study is to develop an antibody-derived immuno-PET imaging agent strategy for targeting FRα in ovarian cancer as a predictor of treatment success. Methods: We developed [89Zr]Zr-DFO-M9346A, a humanized antibody-based radiotracer targeting tumorassociated FRα in the preclinical setting. [89Zr]Zr-DFO-M9346A’s binding ability was tested in an in vitro uptake assay using cell lines with varying FRα expression levels. The diagnostic potential of [89Zr]Zr-M9346A was evaluated in KB and …

Empowering With Prep (E-Prep), A Peer-Led Social Media–Based Intervention To Facilitate Hiv Preexposure Prophylaxis Adoption Among Young Black And Latinx Gay And Bisexual Men: Protocol For A Cluster Randomized Controlled Trial, Viraj V. Patel, Zoë Ginsburg, Sarit A. Golub, Keith J. Horvath, Nataly Rios, Kenneth H. Mayer, Ryunh S. Kim, Julia H. Arnsten

Publications and Research

Background: Young black and Latinx, gay, bisexual, and other men who have sex with men (YBLGBM, aged 18-29 years) have among the highest rates of new HIV infections in the United States and are not consistently reached by existing prevention interventions. Preexposure prophylaxis (PrEP), an oral antiretroviral regimen taken daily by HIV-uninfected individuals to prevent HIV acquisition, is highly efficacious in reducing HIV acquisition and could help stop the HIV epidemic in YBLGBM. Use of social media (eg, Facebook, Twitter, online dating sites) is ubiquitous among young people, providing an efficient avenue to engage YBLGBM to facilitate PrEP adoption.

Objective: …

“My Sexuality…It Creates A Stress”: Hiv-Related Communication Among Bisexual Black And Latino Men, New York City, Kirk D. Henny, Kathryn Drumhiller, Madeline Y. Sutton, Jose Nanín

Publications and Research

Men who have sex with men and women (including bisexual men) comprise 35% of all men who have sex with men (MSM) in the U.S. It is estimated that 121,800 men who have been bisexually active within the past year are living with HIV in the U.S. Communication about HIV may result in risk-reduction behaviors. However, little is known about the nature or context for HIV prevention communication among bisexual men, particularly for blacks and Hispanic/Latinos who are disproportionately at greater HIV risk. Therefore, we explored patterns and contexts of HIV-related communications occurring within personal social networks among bisexual black …

The Price Of A Vote: Diseconomy In Proportional Elections, Hygor Piaget M. Melo, Saulo D. S. Reis, Andre ́ A. Moreira, Hernan Makse, Jose ́ S. Andrade Jr.

Publications and Research

The increasing cost of electoral campaigns raises the need for effective campaign planning and a precise understanding of the return of such investment. Interestingly, despite the strong impact of elections on our daily lives, how this investment is translated into votes is still unknown. By performing data analysis and modeling, we show that top candidates spend more money per vote than the less successful and poorer candidates, a relation that discloses a diseconomy of scale. We demonstrate that such electoral diseconomy arises from the competition between candidates due to inefficient campaign expenditure. Our approach succeeds in two important tests. First, …

Graphic Representations Of Grammatical Gender In Spanish Language Anarchist Publications, Mariel Mercedes Acosta Matos

Publications and Research

This paper offers a descriptive analysis of the suffixes -@, -x, -e and other orthographic innovations as transgressions to the genderedness of Spanish language. First I discuss the grammatical rules of expressing gender in Spanish and a summary of the ongoing debates concerning linguistic sexism and androcentrism in Spanish language. Then I present some examples of the gender neutral suffixes drawn from articles found in 3 “Do It Yourself” journals published online by three anarchist collectives in Latin America.

Supermarket Retailers’ Perspectives On Healthy Food Retail Strategies: In-Depth Interviews, Olivia Martinez, Noemi Rodriguez, Allison Mercurio, Marie Bragg, Brian Elbel

Publications and Research

Background

Excess calorie consumption and poor diet are major contributors to the obesity epidemic. Food retailers, in particular at supermarkets, are key shapers of the food environment which influences consumers’ diets. This study seeks to understand the decision-making processes of supermarket retailers—including motivators for and barriers to promoting more healthy products—and to catalogue elements of the complex relationships between customers, suppliers, and, supermarket retailers.

Methods

We recruited 20 supermarket retailers from a convenience sample of full service supermarkets and national supermarket chain headquarters serving low- and high-income consumers in urban and non-urban areas of New York. Individuals responsible for making …

Adviser Nomination Spurs Questions, Aldemaro Romero Jr.

Publications and Research

After a 19-month delay, the Trump Administration has nominated someone to be the director of the Office of Science and Technology Policy, or as is more colloquially known, the science adviser to the president.

Congress established the White House Office of Science and Technology Policy (OSTP) in 1976. President Gerald Ford, a Republican, signed the act creating the agency into law. That took place after President Nixon disbanded the then-called “President Advisory Committee” in 1973.

The mandate for the agency is to provide the president and others within the Executive Office of the President with advice on the scientific, engineering, …

Rankings Can Be Bad For Colleges’ Health, Aldemaro Romero Jr.

Publications and Research

In previous columns I have reported how a number of external factors, such as funding, demographics, politics and the like have been hurting higher education. In many other cases – overblown athletic programs, misguided marketing, and plain bad leadership – the injuries have been self-inflicted. To these cases we can now add the race for the rankings.

I have argued in this column in the past that rankings like the ones by U.S. News & World Reportand its copycats make little sense. To begin with, many of the things they claim to measure, such as athletics, facilities, and “reputation,” …

“Our Lab Is The Community”: Defining Essential Supporting Infrastructure In Engagement Research, Donald E. Nease Jr., Dee Burton, Sarah L. Cutrona, Lauren Edmundson, Alex H. Krist, Michael Barton Laws, Montelle Tamez

Publications and Research

Introduction: Effective patient engagement is central to patient-centered outcomes research. A well-designed infrastructure supports and facilitates patient engagement, enabling study development and implementation. We sought to understand infrastructure needs from recipients of Patient-Centered Outcomes Research Institute (PCORI) pilot grant awards. Methods: We surveyed recipients of PCORI pilot project awards on self-perceived strengths in engagement infrastructure through PCORI’s Ways of Engaging-Engagement Activity Tool survey, and interviewed leaders of 8 projects who volunteered as exemplars. Descriptive statistics summarized the survey findings. We conducted a thematic analysis of the interview transcripts. Results: Of the 50 surveyed pilots, 22 answered the engagement infrastructure questions …

African Trypanosomes Evade Immune Clearance By Oglycosylation Of The Vsg Surface Coat, Jason Pinger, Dragana Nešić, Liaqat Ali, Francisco Aresta-Branco, Mirjana Lilic, Shanin Chowdhury, Hee-Sook Kim, Joseph Verdi, Jayne Raper, Michael A. J. Ferguson, F. Nina Papavasiliou, C. Erec Stebbins

Publications and Research

The African trypanosome, Trypanosoma brucei spp., is a paradigm for antigenic variation, the orchestrated alteration of cell surface molecules to evade host immunity. The parasite elicits robust antibody-mediated immune responses to its Variant Surface Glycoprotein (VSG) coat, but evades immune clearance by repeatedly accessing a large genetic VSG repertoire and “switching” to antigenically distinct VSGs. This persistent immune evasion has been ascribed exclusively to amino acid variance on the VSG surface presented by a conserved underlying protein architecture. We establish here that this model does not account for the scope of VSG structural and biochemical diversity. The 1.4Å resolution crystal …

Institute For Innovation In Prosecution (Iip) Practitioner Learning: Building A More Equitable And Effective System, Arlana K. Henry

Publications and Research

This report presents the findings from follow-up interviews conducted by the Research and Evaluation Center at John Jay College (JohnJayREC) with prosecutors who attended the 2017 Practitioner Learning seminar hosted by the Institute for Innovation in Prosecution (IIP). Conducted between November 2017 and January 2018, the interviews aimed to evaluate the effectiveness of the resources and tools provided during the seminar in supporting prosecutorial reform. The results were largely positive, with prosecutors expressing strong interest in continued collaboration with the IIP. Key findings include prosecutors’ receptiveness to reform efforts, the positive impact of the seminar on their practices, and the …

Hyper-Selectivity, Racial Mobility, And The Remaking Of Race, Van C. Tran, Jennifer Lee, Oshin Khachikian, Jess Lee

Publications and Research

Recent immigrants to the United States are diverse with regard to selectivity. Hyper-selectivity refers to a dual positive selectivity in which immigrants are more likely to have graduated from college than nonmigrants in sending countries and the host population in the United States. This article addresses two questions. First, how does hyper-selectivity affect second-generation educational outcomes? Second, how does second-generation mobility change the cognitive construction of racial categories? It shows how hyper-selectivity among Chinese immigrants results in positive second-generation educational outcomes and racial mobility for Asian Americans. It also raises the question of whether hyper-selectivity operates similarly for non-Asian groups. …

Directly Light-Regulated Binding Of Rgs-Lov Photoreceptors To Anionic Membrane Phospholipids, Spencer T. Glantz, Erin E. Berlew, Zaynab Jaber, Benjamin S. Schuster, Kevin H. Gardner, Brian Y. Chow

Publications and Research

We report natural light–oxygen–voltage (LOV) photoreceptors with a blue light-switched, high-affinity (KD ∼ 10−7 M), and direct electrostatic interaction with anionic phospholipids. Membrane localization of one such photoreceptor, BcLOV4 from Botrytis cinerea, is directly coupled to its flavin photocycle, and is mediated by a polybasic amphipathic helixinthelinker regionbetween the LOV sensor and its C-terminal domain of unknown function (DUF), as revealed through a combination of bioinformatics, computational protein modeling, structure–function studies, and optogenetic assays in yeast and mammalian cell line expression systems. In model systems, BcLOV4 rapidly translocates from the cytosol to plasma membrane (∼1 second). The reversible electrostatic interaction …

Power Outage Preparedness And Concern Among Vulnerable New York City Residents, Christine Dominianni, Munerah Ahmed, Sarah Johnson, Micheline Blum, Kazuhiko Ito, Kathryn Lane

Publications and Research

Power outages can impact health, and certain populations may be more at risk. Personal preparedness may reduce impacts, but information on power outage preparedness and risk perception among vulnerable populations is limited. We examined power outage preparedness and concern among New York City residents, including vulnerable populations defined as older adults (≥ 65 years), and respondents with household members who require assistance with daily activities or depend on electric medical devices. A random sample telephone survey was conducted during November–December 2016. Preparedness was defined as having a three-day supply of drinking water, non-perishable food, and a working flashlight. Among all …

An Interview With Cesare Montecucco, Mandë Holford, Andreas Rummel

Publications and Research

Cesare Montecucco is a member of the board of various leading scientific journals. His research focus is on the regeneration of the peripheral nervous system and on the mechanisms of action of toxins and related diseases, including tetanus, botulism, anthrax and Helicobacter pylori-associated diseases. In this interview, we talked to Cesare Montecucco about his career, learning and culture.

Uncertain Futures For Private Colleges, Aldemaro Romero Jr.

Publications and Research

Although we hear a lot about problems at public colleges and universities – budget cuts, enrollment issues, political interference – private colleges also have their share of concerns.

Of the more than 4,600 institutions of higher education in this country, a little more than 3,000 (almost two-thirds of the total) are private. Although there are a few exceptions, they tend to be small, at around 2,000 students or fewer.Yet they represent a significant number of the overall number colleges and universities. Obviously not all are created equal. Some of them have large endowments and can a word to be very …

Prmt5-Mediated Regulation Of Developmental Myelination, Antonella Scaglione, Julia Patzig, Jialiang Liang, Rebecca Frawley, Jabez Bok, Angeliki Mela, Camila Yattah, Jingxian Zhang, Shun Xie Teo, Ting Zhou, Shuibing Chen, Emily Bernstein, Peter Canoll, Ernesto Guccione, Patricia Casaccia

Publications and Research

Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are derived from differentiation of oligodendrocyte progenitors through a process requiring cell cycle exit and histone modifications. Here we identify the histone arginine methyl-transferase PRMT5, a molecule catalyzing symmetric methylation of histone H4R3, as critical for developmental myelination. PRMT5 pharmacological inhibition, CRISPR/cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. Conditional ablation of Prmt5 in progenitors results in hypomyelination, reduced survival and differentiation. Decreased histone H4R3 symmetric methylation is followed by increased nuclear acetylation of H4K5, and is rescued by pharmacological inhibition of …