Digital Commons Network^™

Videos In The Kitchen: The Lesbian Herstory Archives As A Moving-Herstorical-Image, Shawn(Ta) D. Smith

Publications and Research

No abstract provided.

Design Collaboration As A Tool For Developing Diversity In The Work Place, Rees E. E. Shad

Publications and Research

Without a doubt the modern workplace is one made up of numerous working professionals graced with an array of varied abilities who work in tandem to meet a common goal. In this article the author recounts his personal journey to embracing the collaborative process and how he has honed and developed the skill set into an important element of design curriculum in order to prepare students for this fundamental market paradigm.

Effect Of Teammates On Changes In Physical Activity In A Statewide Campaign, Tricia M. Leahey, Melissa M. Crane, Angela Marinilli Pinto, Brad A. Weinberg, Rajiv Kumar, Rena R. Wing

Publications and Research

Objective—Most Americans do not meet physical activity recommendations. Statewide campaigns can effectively increase activity levels. Reported herein are physical activity outcomes from Shape Up Rhode Island (SURI) 2007, a statewide campaign to increase steps through team-based competition. Given the importance of social networks in behavior change, this paper focused on the effects of team and team characteristics on activity outcomes. Method—For 16-weeks, 5333 adults comprising 652 teams wore pedometers and reported their steps online. Results—Participants’ daily steps increased from 7029(3915) at baseline to 9393(5976) at SURI end (p<.001). There was a significant intraclass correlation for step change among team members (ICC=.09); thus, an individual’s change in steps was influenced by what team they were on. Moreover, baseline team characteristics predicted individual step change; being on a more active team was associated with greater increases in activity for individual members (p<.001), whereas being on a team with a broad range of steps was associated with smaller changes in activity for individual members (p=.02). Conclusion—These findings are the first to suggest that team members influence individual activity outcomes in team-based statewide campaigns. Future research should explore ways to use social network factors to enhance team-based physical activity programs.

The Inadvertent Alliance Of Anthony Comstock And Margaret Sanger: Abortion, Freedom, And Class In Modern America, Karen Weingarten

Publications and Research

This article investigates how moral-reformer Anthony Comstock, who helped outlaw the practice of birth control and to have abortion criminalized, and Margaret Sanger, founder of Planned Parenthood and birth-control activist, advanced their causes through the discourse of freedom and self-control. While Comstock’s and Sanger’s works are often seen in opposition, this article questions that positioning by pointing out how they both lobbied against accessible abortion using similar tactics. Finally, this article demonstrates how Comstock and Sanger, through different means, worked to present abortion as a depraved practice that would lead to the demise of American society. Presenting Comstock and Sanger …

Autoregulation Of Sinorhizobium Meliloti Exor Gene Expression, Hai-Yang Lu, Hai-Ping Cheng

Publications and Research

The successful nitrogen-fixing symbiosis between the Gram-negative soil bacterium Sinorhizobium meliloti and its leguminous plant host alfalfa (Medicago sativa) requires the bacterial exopolysaccharide succinoglycan. Succinoglycan and flagellum production, along with the ability to metabolize more than 20 different carbon sources and control the expression of a large number of S. meliloti genes, is regulated by the ExoR–ExoS/ChvI signalling pathway. The ExoR protein interacts with and suppresses the sensing activities of ExoS, the membrane-bound sensor of the ExoS/ChvI two-component regulatory system. Here we show that exoR expression is clearly upregulated in the absence of any functional ExoR protein. This upregulation was …

Labor Force And Economic Changes In Cuba, Pavel Vidal Alejandro, Omar Everleny Perez Villanueva, Mario A. Gonzalez-Corzo

Publications and Research

In November 2010, the Cuban government published a 32-page document called “Lineamientos De La Política Económica y Social” [“Guidelines of Economic and Social Policies], which outlines the economic transformations approved in the Sixth Communist Party Congress last April 2011. The guidelines presented in this document expand the economic changes initiated by Raúl Castro in 2008. One of the major changes that already began is the transfer of State workers to the (emerging) private sector. This is the most transformative labor oriented economic adjustment implemented in Cuba so far and is a clear indicator of Cuba’s movement towards a …

Consistency And Precision Of Cancer Reporting In A Multiwave National Panel Survey, Anna Zajacova, Jennifer Beam Dowd, Robert F. Schoeni, Robert B. Wallace

Publications and Research

Background Many epidemiological studies rely on self-reported information, the accuracy of which is critical for unbiased estimates of population health. Previously, accuracy has been analyzed by comparing self-reports to other sources, such as cancer registries. Cancer is believed to be a well-reported condition. This paper uses novel panel data to test the consistency of cancer reports for respondents with repeated self-reports. Methods Data come from 978 adults who reported having been diagnosed with cancer in at least one of four waves of the Panel Study of Income Dynamics, 1999-2005. Consistency of cancer occurrence reports and precision of timing of onset …

Ospie1, The Rice Ortholog Of Arabidopsis Photoperiod-Independent Early Flowering1, Is Essential For Embryo Development, Yonghan Xu, Minjuan Deng, Jianfei Peng, Zhanghua Hu, Lieming Bao, Junming Wang, Zhi-Liang Zheng

Publications and Research

Background The SWR1 complex is important for the deposition of histone variant H2A.Z into chromatin necessary to robustly regulate gene expression during growth and development. In Arabidopsis thaliana, the catalytic subunit of the SWR1-like complex, encoded by PIE1 (PHOTOPERIOD-INDEPENDENT EARLY FLOWERING1), has been shown to function in multiple developmental processes including flowering time pathways and petal number regulation. However, the function of the PIE1 orthologs in monocots remains unknown. Methodology/Findings We report the identification of the rice (Oryza sativa) ortholog, OsPIE1. Although OsPIE1 does not exhibit a conserved exon/intron structure as Arabidopsis PIE1, its encoded protein is highly similar to …

Alternative Trans-Splicing Of Caenorhabditis Elegans Sma-9/Schnurri Generates A Short Transcript That Provides Tissue-Specific Function In Bmp Signaling, Jianghua Yin, Ling Yu, Cathy Savage-Dunn

Publications and Research

Background Transcription cofactors related to Drosophila Schnurri facilitate the transcriptional programs regulated by BMP signaling in C. elegans, Drosophila, Xenopus, and mouse. In different systems, Schnurri homologs have been shown to act as either agonists or antagonists of Smad function, and as either positive or negative regulators of transcription. How Schnurri proteins achieve this diversity of activities is not clear. The C. elegans sma-9/schnurri locus undergoes alternative splicing, including an unusual trans-splicing event that could generate two non-overlapping shorter transcripts.

Results We demonstrate here that the shorter transcripts are expressed in vivo. Furthermore, we find that one of the short …

Dna Adducts Of Decarbamoyl Mitomycin C Efficiently Kill Cells Without Wild-Type P53 Resulting From Proteasome-Mediated Degradation Of Checkpoint Protein 1, Ernest K. Boamah, Angelika Brekman, Maria Tomasz, Natura Myeka, Maria E. Figueiredo-Pereira, Senyene Hunter, Joel Meyer, Rahul C. Bhosle, Jill Bargonetti

Publications and Research

The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than mitomycin C (MC). We recently documented that an increased proportion of mitosene1-β-adduct formation occurs in human cells treated with DMC in comparison to those treated with MC. Here, we compare the cellular and molecular response of human cancer cells treated with MC and DMC. We find the increase in mitosene 1-β-adduct formation correlates with a condensed nuclear morphology and increased cytotoxicity in human cancer cells with or without p53. DMC caused more DNA damage than MC in the nuclear and mitochondrial genomes. Checkpoint 1 …

Comparative Genomics Of The Family Vibrionaceae Reveals The Wide Distribution Of Genes Encoding Virulence-Associated Proteins, Timothy G. Lilburn, Jianying Gu, Hong Cai, Yufeng Wang

Publications and Research

Background Species of the family Vibrionaceae are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important role in the emergence of new pathogenic strains within this family. Data from the sequenced genomes of strains in this family could show how the genes encoded by all these strains, known as the pangenome, are distributed. Information about the core, accessory and panproteome of this family can show how, for example, genes encoding virulence-associated proteins are distributed and help us understand how virulence emerges. Results We deduced the …

Leonard Lief Library Sony Reader Program: Leading Cuny In Digital Media Technology, Stefanie Havelka, Jennifer A. King, Adelaide Soto

Publications and Research

No abstract provided.

Neural Substrates Of Reliability-Weighted Visual-Tactile Multisensory Integration, Michael S. Beauchamp, Siavash Pasalar, Tony Ro

Publications and Research

As sensory systems deteriorate in aging or disease, the brain must relearn the appropriate weights to assign each modality during multisensory integration. Using blood-oxygen level dependent functional magnetic resonance imaging of human subjects, we tested a model for the neural mechanisms of sensory weighting, termed “weighted connections.” This model holds that the connection weights between early and late areas vary depending on the reliability of the modality, independent of the level of early sensory cortex activity. When subjects detected viewed and felt touches to the hand, a network of brain areas was active, including visual areas in lateral occipital cortex, …

Optimizing Radiology Peer Review: A Mathematical Model For Selecting Future Cases Based On Prior Errors, Yun Robert Sheu, Elie Feder, Igor Balsim, Victor F. Levin, Andrew G. Bleicher, Barton F. Branstetter Iv

Publications and Research

Introduction: Peer review is an essential process for physicians because it facilitates improved quality of patient care and continuing physician learning and improvement. However, peer review often is not well received by radiologists, who note that it is time intensive, subjective, and lacks demonstrable impact on patient care. Current advances in peer review include the RADPEER system with its standardization of discrepancies and incorporation of the peer review process into the PACS itself. Our purpose was to build on RADPEER and similar systems by using a mathematical model to optimally select the types of cases to be reviewed, for each …

Interactive Kinds, Muhammad Ali Khalidi

Publications and Research

This paper examines the phenomenon of 'interactive kinds' first identified by Ian Hacking. An interactive kind is one that is created or significantly modified once a concept of it has been formulated and acted upon in certain ways. Interactive kinds may also 'loop back' to influence our concepts and classifications. According to Hacking, interactive kinds are found exclusively in the human domain. After providing a general account of interactive kinds and outlining their philosophical significance, I argue that they are not confined to the human realm, but that they can also occur elsewhere. Hence, I conclude by arguing that interactive …

From Disruptive Decline To Gradual Recovery: 2009 In Review, Eugene Spruck

Publications and Research

No abstract provided.

A Genealogical Review Of The Worldview Framework In African-Centered Psychology, Karanja Keita Carroll

Publications and Research

Of all the subject/content areas within Africana Studies, African-centered (African/Africana/Black) psychology has been instrumental in advancing culturally-specific theory and research. Central to the field of African-centered psychology is the usage of worldview as the conceptual and philosophical framework. This essay provides a genealogical review of the worldview framework as discussed within African-centered psychology. A focus is on understanding the developmental history and usage of worldview as it relates to producing culturally-specific theory and research consistent with the aims and goals of African-centered psychology and Africana Studies.

Marketing And Communications Librarians: An Exploration Of Roles And Responsibilities, Mark Aaron Polger, Karen Okamoto

Publications and Research

No abstract provided.

A History And One Or Two Things I’Ve Learned, Irvin Sam Schonfeld

Publications and Research

No abstract provided.

Newborn Infants Learn During Sleep, William P. Fifer, Dana L. Byrd, Michelle Kaku, Inge-Marie Eigsti, Joseph R. Isler, Jillian Grose-Fifer, Amanda R. Tarullo, Peter D. Balsam

Publications and Research

Newborn infants must rapidly adjust their physiology and behavior to the specific demands of the novel postnatal environment. This adaptation depends, at least in part, on the infant’s ability to learn from experiences. We report here that infants exhibit learning even while asleep. Bioelectrical activity from face and scalp electrodes was recorded from neonates during an eye movement conditioning procedure in which a tone was followed by a puff of air to the eye. Sleeping newborns rapidly learned the predictive relationship between the tone and the puff. Additionally, in the latter part of training, these infants exhibited a frontally maximum …

Induction Of Neuro-Protective/Regenerative Genes In Stem Cells Infiltrating Post-Ischemic Brain Tissue, Gokhan Yilmaz, J Steven Alexander, Cigdem Erkuran Yilmaz, D Neil Granger

Publications and Research

Background- Although the therapeutic potential of bone marrow-derived stromal stem cells (BMSC) has been demonstrated in different experimental models of ischemic stroke, it remains unclear how stem cells (SC) induce neuroprotection following stroke. In this study, we describe a novel method for isolating BMSC that infiltrate postischemic brain tissue and use this method to identify the genes that are persistently activated or depressed in BMSC that infiltrate brain tissue following ischemic stroke. Methods- Ischemic strokes were induced in C57BL/6 mice by middle cerebral artery occlusion for 1 h, followed by reperfusion. BMSC were isolated from H-2 Kb-tsA58 (immortomouse™) mice, and …

Estimated Birth Weight And Adult Cardiovascular Risk Factors In A Developing Southern Chinese Population: A Cross Sectional Study, C. Mary Schooling, C. Q. Jiang, T. H. Lam, B. J. Cowling, S. L. Yeung, W. S. Zhang, K. K. Cheng, G. M. Leung

Publications and Research

Background: Birth weight is negatively associated with cardiovascular diseases and diabetes, but the associations are less well-established in developing populations where birth weight is often unavailable. We studied the association of birth weight and cardiovascular risk, using birth rank as an instrumental variable, in Southern China.

Methods: We used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 & 3 (2005-8) to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older …

Measuring Social Capital As An Outcome Of Service Learning, Maria J. D'Agostino

Publications and Research

Service-learning has been put forth as one of the proposed solutions to increasing social capital. However, service-learning research has not significantly addressed the impact of service learning on social capital. Unlike most previous studies, this research used quantitative analysis to measure the effect of university service-learning programs on social capital by examining the question: What impact do service-learning programs have on social capital post-graduation? This study showed that service learning addresses the civic engagement problem by providing evidence suggesting that service learning predicts social capital post-graduation.

Comparing The Validity Of Five Participation Instruments In Persons With Spinal Conditions, Vanessa K. Noonan, Jacek A. Kopec, Luc Noreau, Joel Singer, Louise C. Mâsse, Hongbin Zhang, Marcel F. Dvorak

Publications and Research

Objective: To evaluate and compare the construct validity of 5 participation instruments developed using the International Classification of Functioning, Disability and Health (ICF). Methods: A total of 545 subjects diagnosed and treated for a spinal condition at an acute hospital were followed-up and consented to complete a questionnaire. Subjects completed 5 participation instruments (Impact on Participation and Autonomy (IPA), Keele Assessment of Participation (KAP), Participation Measure-Post Acute Care (PM-PAC), Participation Objective Participation Subjective (POPS), World Health Organization Disability Assessment Schedule II (WHODAS II)). In addition, each subject completed a health status instrument and a quality of life instrument. The dimensionality, …

The Dunaliella Salina Organelle Genomes: Large Sequences, Inflated With Intronic And Intergenic Dna, David Roy Smith, Robert W. Lee, John C. Cushman, Jon K. Magnuson, Duc Tran, Jürgen Ew Polle

Publications and Research

Background Dunaliella salina Teodoresco, a unicellular, halophilic green alga belonging to the Chlorophyceae, is among the most industrially important microalgae. This is because D. salina can produce massive amounts of β-carotene, which can be collected for commercial purposes, and because of its potential as a feedstock for biofuels production. Although the biochemistry and physiology of D. salina have been studied in great detail, virtually nothing is known about the genomes it carries, especially those within its mitochondrion and plastid. This study presents the complete mitochondrial and plastid genome sequences of D. salina and compares them with those of the model …

Interactions Of Host Proteins With The Murine Leukemia Virus Integrase, Barbara Studamire, Stephen P. Goff

Publications and Research

Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome. Productive and efficient proviral integration is critical for retroviral function and is the key step in establishing a stable and productive infection, as well as the mechanism by which host genes are activated in leukemogenesis. Host factors are widely anticipated to be involved in all stages of the retroviral life cycle, and the identification of integrase interacting factors has the potential to increase our understanding of mechanisms by which the incoming virus might appropriate cellular …

Sensitivity Analysis Of B-Factor In Microwave Emission Model For Soil Moisture Retrieval: A Case Study For Smap Mission, Dugwon Seo, Tarendra Lakhankar, Reza Khanbilvardi

Publications and Research

Sensitivity analysis is critically needed to better understand the microwave emission model for soil moisture retrieval using passive microwave remote sensing data. The vegetation b-factor along with vegetation water content and surface characteristics has significant impact in model prediction. This study evaluates the sensitivity of the b-factor, which is function of vegetation type. The analysis is carried out using Passive and Active L and S-band airborne sensor (PALS) and measured field soil moisture from Southern Great Plains experiment (SGP99). The results show that the relative sensitivity of the b-factor is 86% in wet soil condition and 88% in high vegetated …

Hsp110 Chaperones Control Client Fate Determination In The Hsp70–Hsp90 Chaperone System, Atin K. Mandal, Patrick A. Gibney, Nadinath B. Nillegoda, Maria A. Theodoraki, Avrom J. Caplan, Kevin A. Morano

Publications and Research

The Hsp110 family of protein chaperones was known to promote maturation of Hsp90 client proteins. The yeast Hsp110 ortholog Sse1 is now shown to influence the decision to fold or degrade substrates of the Hsp70–Hsp90 chaperone system when maturation is compromised.

Location Of Modulatory Β Subunits In Bk Potassium Channels, Guoxia Liu, Xiaowei Niu, Roland S. Wu, Neelesh Chudasama, Yongneng Yao, Xin Jin, Richard Weinberg, Sergey I. Zakharov, Howard Motoike, Steven O. Marx, Arthur Karlin

Publications and Research

Large-conductance voltage- and calcium-activated potassium (BK) channels contain four pore-forming α subunits and four modulatory β subunits. From the extents of disulfide cross-linking in channels on the cell surface between cysteine (Cys) substituted for residues in the first turns in the membrane of the S0 transmembrane (TM) helix, unique to BK α, and of the voltage-sensing domain TM helices S1–S4, we infer that S0 is next to S3 and S4, but not to S1 and S2. Furthermore, of the two β1 TM helices, TM2 is next to S0, and TM1 is next to TM2. Coexpression of α with two substituted …

Smap-Ws: A Parallel Web Service For Structural Proteome-Wide Ligand-Binding Site Comparison, Jingyuan Ren, Lei Xie, Wilfred W. Li, Philip E. Bourne

Publications and Research

The proteome-wide characterization and analysis of protein ligand-binding sites and their interactions with ligands can provide pivotal information in understanding the structure, function and evolution of proteins and for designing safe and efficient therapeutics. The SMAP web service (SMAP-WS) meets this need through parallel computations designed for 3D ligand-binding site comparison and similarity searching on a structural proteome scale. SMAP-WS implements a shape descriptor (the Geometric Potential) that characterizes both local and global topological properties of the protein structure and which can be used to predict the likely ligand-binding pocket [Xie,L. and Bourne,P.E. (2007) A robust and efficient algorithm for …