Digital Commons Network^™

Lung Cancer Screening For The Poor And Underserved: Should Routine Screening Be Performed?, Vaibhav Verma, Vladimir K. Gotlieb, Joshua Fogel, Alan S. Multz, Geeti Sharma

Publications and Research

Background: Lung cancer is a leading cause of death in United States. A recent study using low dose CT scans for screening long term smokers for lung cancer has, for the first time, demonstrated reduction in mortality, although it is not a standard of care in the community yet.

Methods: We analyzed lung cancer data for stages 0 through 4 for 1,412 individuals from, a public hospital, Nassau University Medical Center (NUMC) with patients of lower income, two private hospitals, North Shore University Hospital (NSUH) and Long Island Jewish Hospital (LIJ), with patients of higher income, with average household income …

Fundamental Limits On Wavelength, Efficiency And Yield Of The Charge Separation Triad, Alexander Punnoose, Liza Mcconnell, Wei Liu, Andrew C. Mutter, Ronald Koder

Publications and Research

In an attempt to optimize a high yield, high efficiency artificial photosynthetic protein we have discovered unique energy and spatial architecture limits which apply to all light-activated photosynthetic systems. We have generated an analytical solution for the time behavior of the core three cofactor charge separation element in photosynthesis, the photosynthetic cofactor triad, and explored the functional consequences of its makeup including its architecture, the reduction potentials of its components, and the absorption energy of the light absorbing primary-donor cofactor. Our primary findings are two: First, that a high efficiency, high yield triad will have an absorption frequency more than …

Squalicorax Chips A Tooth: A Consequence Of Feeding-Related Behavior From The Lowermost Navesink Formation (Late Cretaceous: Campanian-Maastrichtian) Of Monmouth County, New Jersey, Usa, Martin A. Becker, John A. Chamberlain Jr.

Publications and Research

Chipped and broken functional teeth are common in modern sharks with serrated tooth shape. Tooth damage consists of splintering, cracking, and flaking near the cusp apex where the enameloid is broken and exposes the osteodentine and orthodentine. Such damage is generally viewed as the result of forces applied during feeding as the cusp apex impacts the skeletal anatomy of prey. Damage seen in serrated functional teeth from sharks Squalicorax kaupi [1] and Squalicorax pristodontus [1] from the late Cretaceous lowermost Navesink Formation of New Jersey resembles that occurring in modern sharks and suggests similar feeding behavior. Tumbling experiments using serrated …

Dynamic Gene Expression In The Human Cerebral Cortex Distinguishes Children From Adults, Kirstin N. Sterner, Amy Weckle, Harry T. Chugani, Adi L. Tarca, Chet C. Sherwood, Patrick R. Hof, Christopher W. Kuzawa, Amy M. Boddy, Asad Abbas, Ryan L. Raaum, Lucie Grégoire, Leonard Lipovich, Lawrence I. Grossman, Monica Uddin, Morris Goodman, Derek E. Wildman

Publications and Research

In comparison with other primate species, humans have an extended juvenile period during which the brain is more plastic. In the current study we sought to examine gene expression in the cerebral cortex during development in the context of this adaptive plasticity. We introduce an approach designed to discriminate genes with variable as opposed to uniform patterns of gene expression and found that greater inter-individual variance is observed among children than among adults. For the 337 transcripts that show this pattern, we found a significant overrepresentation of genes annotated to the immune system process (pFDR>0). Moreover, genes known to …

Under The Gun: Ongoing Assaults On Bahrain’S Health System, Richard Sollom, Holly G. Atkinson

Publications and Research

In February 2011, the Government of Bahrain began targeting health professionals who treated protesters. In April 2012, PHR's Richard Sollom, Deputy Director, and Holly Atkinson, MD, FACP, past President of PHR's Board and volunteer expert, authored a report showing the devastation on Bahrain's health system that have resulted from the Government of Bahrain’s continued assault on doctors, patients, and the healthcare system.

Crossing Over…Markov Meets Mendel, Saad Mneimneh

Publications and Research

Chromosomal crossover is a biological mechanism to combine parental traits. It is perhaps the first mechanism ever taught in any introductory biology class. The formulation of crossover, and resulting recombination, came about 100 years after Mendel's famous experiments. To a great extent, this formulation is consistent with the basic genetic findings of Mendel. More importantly, it provides a mathematical insight for his two laws (and corrects them). From a mathematical perspective, and while it retains similarities, genetic recombination guarantees diversity so that we do not rapidly converge to the same being. It is this diversity that made the study of …

Mapping Populations At Risk: Improving Spatial Demographic Data For Infectious Disease Modeling And Metric Derivation, Andrew J. Tatem, Susana Adamo, Nita Bharti, Clara R. Burgert, Marcia Castro, Audrey Dorelien, Gunter Fink, Catherine Linard, Mendelsohn John, Livia Montana, Mark R. Montgomery, Andrew Nelson, Abdisalan M. Noor, Deepa Pindolia, Greg Yetman, Deborah Balk

Publications and Research

The use of Global Positioning Systems (GPS) and Geographical Information Systems (GIS) in disease surveys and reporting is becoming increasingly routine, enabling a better understanding of spatial epidemiology and the improvement of surveillance and control strategies. In turn, the greater availability of spatially referenced epidemiological data is driving the rapid expansion of disease mapping and spatial modeling methods, which are becoming increasingly detailed and sophisticated, with rigorous handling of uncertainties. This expansion has, however, not been matched by advancements in the development of spatial datasets of human population distribution that accompany disease maps or spatial models. Where risks are heterogeneous …

A Comparative Genomics Screen Identifies A Sinorhizobium Meliloti 1021 Sodm-Like Gene Strongly Expressed Within Host Plant Nodules, Clothilde Queiroux, Brian K. Washburn, Olivia M. Davis, Jamie Stewart, Tess E. Brewer, Michael R. Lyons, Kathryn M. Jones

Publications and Research

Background We have used the genomic data in the Integrated Microbial Genomes system of the Department of Energy’s Joint Genome Institute to make predictions about rhizobial open reading frames that play a role in nodulation of host plants. The genomic data was screened by searching for ORFs conserved in α-proteobacterial rhizobia, but not conserved in closely-related non-nitrogen-fixing α-proteobacteria. Results Using this approach, we identified many genes known to be involved in nodulation or nitrogen fixation, as well as several new candidate genes. We knocked out selected new genes and assayed for the presence of nodulation phenotypes and/or nodule-specific expression. One …

Magecomet—Web Application For Harmonizing Existing Large-Scale Experiment Descriptions, Vincent Xue, Tony Burdett, Margus Lukk, Julie Taylor, Alvis Brazma, Helen Parkinson

Publications and Research

Motivation: Meta-analysis of large gene expression datasets obtained from public repositories requires consistently annotated data. Curation of such experiments, however, is an expert activity which involves repetitive manipulation of text. Existing tools for automated curation are few, which bottleneck the analysis pipeline. Results: We present MageComet, a web application for biologists and annotators that facilitates the re-annotation of gene expression experiments in MAGE-TAB format. It incorporates data mining, automatic annotation, use of ontologies and data validation to improve the consistency and quality of experimental meta-data from the ArrayExpress Repository. Availability and implementation: Source and tutorials for MageComet are openly available …

Posttraumatic Stress And Myocardial Infarction Risk Perceptions In Hospitalized Acute Coronary Syndrome Patients, Donald Edmondson, Jonathan A. Shaffer, Ellen-Ge Denton, Daichi Shimbo, Lynn Clemow

Publications and Research

Posttraumatic stress disorder (PTSD) is related to acute coronary syndrome (ACS; i.e., myocardial infarction or unstable angina) recurrence and poor post-ACS adherence to medical advice. Since risk perceptions are a primary motivator of adherence behaviors, we assessed the relationship of probable PTSD to ACS risk perceptions in hospitalized ACS patients (n = 420). Participants completed a brief PTSD screen 3-7 days post-ACS, and rated their 1-year ACS recurrence risk relative to other men or women their age. Most participants exhibited optimistic bias (mean recurrence risk estimate between "average" and "below average"). Further, participants who screened positive for current PTSD (n …

The Association Between Marital Transitions, Body Mass Index, And Weight: A Review Of The Literature, Lauren Dinour, May May Leung, Gina Tripicchio, Sahar Khan, Ming-Chin Yeh

Publications and Research

Objective: To examine the association between different marital transitions and changes in body mass index (BMI) and body weight.

Methods: A systematic literature search was conducted for peer-reviewed articles published between January 1990 and December 2011. Longitudinal studies were included if they compared dependent variables, such as BMI or weight, before and after a change in marital status.

Results: Twenty articles were included: 4 articles described only transitions into marriage and/or cohabitation, 2 articles described only transitions out of marriage and/or cohabitation, and 14 articles described both. Overall, transitions into marriage were associated with weight gain, whereas transitions out of …

Blending, Mixing, And Processing: Strategies Used To Engage Students In The Classroom, Mark Aaron Polger, Karen Okamoto

Publications and Research

No abstract provided.

A Chemical Specialty Semantic Network For The Unified Medical Language System, C Paul Morrey, Yehoshua Perl, Michael Halper, Ling Chen, Huanying “Helen” Gu

Publications and Research

Background Terms representing chemical concepts found the Unified Medical Language System (UMLS) are used to derive an expanded semantic network with mutually exclusive semantic types. The UMLS Semantic Network (SN) is composed of a collection of broad categories called semantic types (STs) that are assigned to concepts. Within the UMLS’s coverage of the chemical domain, we find a great deal of concepts being assigned more than one ST. This leads to the situation where the extent of a given ST may contain concepts elaborating variegated semantics. A methodology for expanding the chemical subhierarchy of the SN into a finer-grained categorization …

Understanding And Addressing Unique Needs Of Diabetes In Asian Americans, Native Hawaiians, And Pacific Islanders, George L. King, Marguerite J. Mcneely, Lorna E. Thorpe, Marjorie L.M. Mau, Jocelyn Ko, Lenna L. Liu, Angela Sun, William C. Hsu, Edward A. Chow

Publications and Research

No abstract provided.

Pre-Whaling Genetic Diversity And Population Ecology In Eastern Pacific Gray Whales: Insights From Ancient Dna And Stable Isotopes, S Elizabeth Alter, Seth D. Newsome, Stephen R. Palumbi

Publications and Research

Commercial whaling decimated many whale populations, including the eastern Pacific gray whale, but little is known about how population dynamics or ecology differed prior to these removals. Of particular interest is the possibility of a large population decline prior to whaling, as such a decline could explain the ,5-fold difference between genetic estimates of prior abundance and estimates based on historical records. We analyzed genetic (mitochondrial control region) and isotopic information from modern and prehistoric gray whales using serial coalescent simulations and Bayesian skyline analyses to test for a pre-whaling decline and to examine prehistoric genetic diversity, population dynamics and …

Iconic Memory Requires Attention, Marjan Persuh, Boris Genzer, Robert D. Melara

Publications and Research

Two experiments investigated whether attention plays a role in iconic memory, employing either a change detection paradigm (Experiment 1) or a partial-report paradigm (Experiment 2). In each experiment, attention was taxed during initial display presentation, focusing the manipulation on consolidation of information into iconic memory, prior to transfer into working memory. Observers were able to maintain high levels of performance (accuracy of change detection or categorization) even when concurrently performing an easy visual search task (low load). However, when the concurrent search was made difficult (high load), observers' performance dropped to almost chance levels, while search accuracy held at single-task …

The Conundrum Of Functional Brain Networks: Small-World Efficiency Or Fractal Modularity, Lazaros K. Gallos, Mariano Sigman, Hernán A. Makse

Publications and Research

The human brain has been studied at multiple scales, from neurons, circuits, areas with well-defined anatomical and functional boundaries, to large-scale functional networks which mediate coherent cognition. In a recent work, we addressed the problem of the hierarchical organization in the brain through network analysis. Our analysis identified functional brain modules of fractal structure that were inter-connected in a small-world topology. Here, we provide more details on the use of network science tools to elaborate on this behavior. We indicate the importance of using percolation theory to highlight the modular character of the functional brain network. These modules present a …

Through My Tears, Edgar Nkosi White

Publications and Research

No abstract provided.

Hohenberg-Kohn And Percus-Levy-Lieb Proofs Of Density-Functional Theory, Viraht Sahni, Xiao-Yin Pan

Publications and Research

The premise of density-functional theory is that knowledge of the ground-state density uniquely determines the Hamiltonian, and thereby, via solution of the corresponding time-independent Schrodinger equation, all the properties of the system. The density therefore constitutes a basic variable of quantum mechanics. There are at present two paths from the density to the Hamiltonian: the Hohenberg and Kohn proof of the bijectivity between the external potential and the basic variable, and the Percus, Levy, and Lieb constrained-search proof. We argue the Hohenberg- and Kohn-type proof to be the more fundamental, and that this is the case in general when both …

Interplay Of The Glass Transition And The Liquid-Liquid Phase Transition In Water, Nicolas Giovambattista, Thomas Loerting, Boris R. Lukanov, Francis W. Starr

Publications and Research

Water has multiple glassy states, often called amorphous ices. Low-density (LDA) and high-density (HDA) amorphous ice are separated by a dramatic, first-order like phase transition. It has been argued that the LDA-HDA transformation connects to a first-order liquid-liquid phase transition (LLPT) above the glass transition temperature Tg. Direct experimental evidence of the LLPT is challenging to obtain, since the LLPT occurs at conditions where water rapidly crystallizes. In this work, we explore the implications of a LLPT on the pressure dependence of Tg(P) for LDA and HDA by performing computer simulations of two water models – one with a LLPT, …

Cost Effective Malaria Risk Control Using Remote Sensing And Environmental Data, Md Zahidur Rahman, Leonid Roytman, Abdel Hamid Kadik

Publications and Research

Malaria transmission in many part of the world specifically in Bangladesh and southern African countries is unstable and epidemic. An estimate of over a million cases is reported annually. Malaria is heterogeneous, potentially due to variations in ecological settings, socio-economic status, land cover, and agricultural practices. Malaria control only relies on treatment and supply of bed networks. Drug resistance to these diseases is widespread. Vector control is minimal. Malaria control in those countries faces many formidable challenges such as inadequate accessibility to effective treatment, lack of trained manpower, inaccessibility of endemic areas, poverty, lack of education, poor health infrastructure and …

Twenty Years After: Armenian Research Libraries Today, D. Aram Donabedian, John Carey, Arshak Balayan

Publications and Research

Since achieving statehood in 1991, Armenia has faced major economic and political obstacles which have significantly affected the nation’s research libraries. This research paper will quantitatively and qualitatively examine the challenges facing Armenian research libraries just over twenty years after the collapse of the Soviet Union. Specifically, the authors analyze their interviews with five library administrators at five major institutions, respectively. These include Yerevan State University Library, the National Library of Armenia, the Fundamental Scientific Library of the National Academy of Sciences of Armenia, the Republican Scientific-Medical Library of Armenia, and the Papazian Library of the American University of Armenia. …

The Manufacture Of Lifestyle: The Role Of Corporations In Unhealthy Living, Nicholas Freudenberg

Publications and Research

Recently, researchers have debated two views on the connection between lifestyle and health. In the first, health-related lifestyles including tobacco and alcohol use, diet, and physical activity are seen as primary influences on health. In the second, social stratification is the dominant influence with lifestyles simply markers of social status. Neither approach leads to interventions that can reverse the world's most serious health problems. This article proposes that corporate practices are a dominant influence on the lifestyles that shape patterns of health and disease. Modifying business practices that promote unhealthy lifestyles is a promising strategy for improving population health. Corporations …

High Tech Tethers And Work-Family Conflict: A Conservation Of Resources Approach, Katherine M. Richardson, Cynthia A. Thompson

Publications and Research

This is one of the first studies to empirically examine the relationship between wireless communications technology and work interference with family, and results shed light on the motivating factors that influence individuals to continuously engage with mobile technologies, sometimes to their personal detriment. We draw from Conservation of Resources (COR) theory to examine the relationship between using mobile communications technologies during non-work time (e.g., evenings, weekends, vacation) and psychological variables related to work-family conflict and well being, and whether this relationship is mediated by perceptions of job control and detachment from work. We collected data from 139 full-time working adults …

Pointcut Rejuvenation: Recovering Pointcut Expressions In Evolving Aspect-Oriented Software, Raffi Khatchadourian, Phil Greenwood, Awais Rashid, Harry Xu

Publications and Research

Pointcut fragility is a well-documented problem in Aspect-Oriented Programming; changes to the base code can lead to join points incorrectly falling in or out of the scope of pointcuts. In this paper, we present an automated approach that limits fragility problems by providing mechanical assistance in pointcut maintenance. The approach is based on harnessing arbitrarily deep structural commonalities between program elements corresponding to join points selected by a pointcut. The extracted patterns are then applied to later versions to offer suggestions of new join points that may require inclusion. To illustrate that the motivation behind our proposal is well founded, …

Bridging The Gap Through Collaboration:, Rebecca Arliss, Carlos Arguelles, Rodolfo Hernandez

Publications and Research

No abstract provided.

Off To Market We Go: A Content Analysis Of Marketing And Promotion Skills In Academic Librarian Job Ads, Karen Okamoto, Mark Aaron Polger

Publications and Research

This exploratory study analyzed the presence of marketing and promotional responsibilities and qualifications listed in selected job advertisements for academic librarians. A content analysis was employed to analyze job advertisements for academic librarians who possessed marketing,promotion, public relations, outreach, and liaison skills. Job advertisements were selected from January 2000 to December 2010. A total of 149 advertisements were analyzed. The authors found that promotional responsibilities were advertised across the 10-year period, but marketing responsibilities were not. Prior promotional and marketing experience was not widely required. Some libraries advertised marketing librarian positions with responsibilities such as branding and social networking. The …

Persistent Disparities In Cholesterol Screening Among Immigrants To The United States, Jim P. Stimpson, Fernando A. Wilson, Rosenda Murillo, Jose A. Pagan

Publications and Research

Background: This study compared differences in cholesterol screening among immigrant populations and US born race/ethnic groups and whether improving access to health care reduced differences in screening.

Methods: Self-reported cholesterol screening for adults was calculated from multivariate logistic regression analysis of the 1988–2008 National Health and Nutrition Examination Surveys (N = 17,118). Immigrant populations were classified by place of birth and length of residency.

Results: After adjusting for individual characteristics and access to health care, the multivariate adjusted probability of cholesterol screening is significantly lower for persons originating from Mexico (70.9%) compared to persons born in the US (80.1%) or …

Comparison Of Two Actigraph Accelerometer Generations In The Assessment Of Physical Activity In Free Living Conditions, Jérémy Vanhelst, Jacques Mikulovic, Gilles Bui-Xuan, Olivier Dieu, Thomas Blondeau, Paul Fardy, Laurent Béghin

Publications and Research

Background The aim of this study was to compare physical activity measured using GT1M ActiGraph and GT3X ActiGraph accelerometers in free living conditions. Findings Twenty-five adults wore GT1M and GT3X Actigraph accelerometers simultaneously during a typical weekday of activity. Data were uploaded from the monitor to a computer at the end of test (one day). Previously established thresholds were used for defining time spent at each level of physical activity, physical activity was assessed at varying intensities comparing data from the two accelerometers by ANOVA and Bland and Altman statistical analysis. The concordance correlation coefficient between accelerometers at each intensity …

Validation Of Noaa-Interactive Multisensor Snow And Ice Mapping System (Ims) By Comparison With Ground-Based Measurements Over Continental United States, Christine Chen, Tarendra Lakhankar, Peter Romanov, Sean Helfrich, Al Powell, Reza Khanbilvardi

Publications and Research

In this study, daily maps of snow cover distribution and sea ice extent produced by NOAA’s interactive multisensor snow and ice mapping system (IMS) were validated using in situ snow depth data from observing stations obtained from NOAA’s National Climatic Data Center (NCDC) for calendar years 2006 to 2010. IMS provides daily maps of snow and sea ice extent within the Northern Hemisphere using data from combination of geostationary and polar orbiting satellites in visible, infrared and microwave spectrums. Statistical correspondence between the IMS and in situ point measurements has been evaluated assuming that ground measurements are discrete and continuously …