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Articles 7711 - 7740 of 10369
Full-Text Articles in Entire DC Network
Γ-Synuclein Interacts With Phospholipase Cβ2 To Modulate G Protein Activation, Urszula Golebiewska, Yuanjian Guo, Narindra Khalikaprasad, Cassandra Zurawsky, V. Siddhartha Yerramilli, Suzanne Scarlata
Γ-Synuclein Interacts With Phospholipase Cβ2 To Modulate G Protein Activation, Urszula Golebiewska, Yuanjian Guo, Narindra Khalikaprasad, Cassandra Zurawsky, V. Siddhartha Yerramilli, Suzanne Scarlata
Publications and Research
Phospholipase Cβ2 (PLC β2) is activated by G proteins and generates calcium signals in cells. PLCβ2 is absent in normal breast tissue, but is highly expressed in breast tumors where its expression is correlated with the progression and migration of the tumor. This pattern of expression parallels the expression of the breast cancer specific gene protein 1 which is also known as γ-synuclein. The cellular function of γ-synuclein and the role it plays in proliferation are unknown. Here, we determined whether γ-synuclein can interact with PLCβ2 and affect its activity. Using co-immunprecitation and co-immunofluorescence, we find that in both benign …
Communication Activity In A Social Network: Relation Between Long-Term Correlations And Inter-Event Clustering, Diego Rybski, Sergey V. Buldyrev, Shlomo Havlin, Fredrik Liljeros, Hernán A. Makse
Communication Activity In A Social Network: Relation Between Long-Term Correlations And Inter-Event Clustering, Diego Rybski, Sergey V. Buldyrev, Shlomo Havlin, Fredrik Liljeros, Hernán A. Makse
Publications and Research
Human communication in social networks is dominated by emergent statistical laws such as non-trivial correlations and temporal clustering. Recently, we found long-term correlations in the user's activity in social communities. Here, we extend this work to study the collective behavior of the whole community with the goal of understanding the origin of clustering and long-term persistence. At the individual level, we find that the correlations in activity are a byproduct of the clustering expressed in the power-law distribution of inter-event times of single users, i.e. short periods of many events are separated by long periods of no events. On the …
Pricing Options On Foreign Currency With A Preset Exchange Rate, Avner Wolf, Christopher Heseel
Pricing Options On Foreign Currency With A Preset Exchange Rate, Avner Wolf, Christopher Heseel
Publications and Research
This paper presents a new option that can be used by agents for managing foreign exchange risk. Unlike the Garman Kolhagen model [1], (GK), this paper presents a new model with a preset exchange rate (PE), that allows the agent to take advantage of the his/her view on both the direction and magnitude of rate movement and as such provides this agent with more choices. The model has a provision for an automatic exchange of the payoff at a preset exchange rate, and upon expiration gives the agent the choice of keeping the payoff in the foreign currency or exchanging …
Weaponizing Tear Gas: Bahrain’S Unprecedented Use Of Toxic Chemical Agents Against Civilians., Richard Sollom, Holly G. Atkinson
Weaponizing Tear Gas: Bahrain’S Unprecedented Use Of Toxic Chemical Agents Against Civilians., Richard Sollom, Holly G. Atkinson
Publications and Research
The Bahraini government’s response to the early 2011 pro-democracy protests was brutal, systematic, and violent. In addition to birdshot and rubber bullets, government law enforcement attacked unarmed protestors with toxic chemical agents including tear gas. The government’s crackdown on the medical profession was especially harmful, as security forces arrested and detained doctors, raided health facilities, and obstructed patients from receiving necessary care. This report’s findings are based on field research that the authors conducted in Bahrain (April 2012) to investigate excessive use of force by law enforcement officials since June 2011—the end of Bahrain’s state of emergency. The medico-legal team …
Review Of Dan Reiter’S "How Wars End", Zachary C. Shirkey
Review Of Dan Reiter’S "How Wars End", Zachary C. Shirkey
Publications and Research
No abstract provided.
A New Nonlinear Analytical Model For Canopy Flow Over A Forested Hill, Weiguo Wang, Chuixiang Yi
A New Nonlinear Analytical Model For Canopy Flow Over A Forested Hill, Weiguo Wang, Chuixiang Yi
Publications and Research
A new nonlinear analytical model for canopy flow over gentle hills is presented. This model is established based on the assumption that three major forces (pressure gradient, Reynolds stress gradient, and nonlinear canopy drag) within canopy are in balance for gentle hills under neutral conditions. The momentum governing equation is closed by the velocity-squared law. This new model has many advantages over the model developed by Finnigan and Belcher (2004, hereafter referred to as FB04) in predicting canopy wind velocity profiles in forested hills in that: (1) this model predictions are more realistic because the surface drag can be taken …
Loss Of A 20s Proteasome Activator In Saccharomyces Cerevisiae Downregulates Genes Important For Genomic Integrity, Increases Dna Damage, And Selectively Sensitizes Cells To Agents With Diverse Mechanisms Of Action, Kevin M. Doherty, Leah D. Pride, James Lukose, Brian E. Snydsman, Ronald Charles, Ajay Pramanik, Eric G. Muller, David Botstein, Carol Wood Moore
Loss Of A 20s Proteasome Activator In Saccharomyces Cerevisiae Downregulates Genes Important For Genomic Integrity, Increases Dna Damage, And Selectively Sensitizes Cells To Agents With Diverse Mechanisms Of Action, Kevin M. Doherty, Leah D. Pride, James Lukose, Brian E. Snydsman, Ronald Charles, Ajay Pramanik, Eric G. Muller, David Botstein, Carol Wood Moore
Publications and Research
Cytoprotective functions of a 20S proteasome activator were investigated. Saccharomyces cerevisiae Blm10 and human 20S proteasome activator 200 (PA200) are homologs. Comparative genome-wide analyses of untreated diploid cells lacking Blm10 and growing at steady state at defined growth rates revealed downregulation of numerous genes required for accurate chromosome structure, assembly and repair, and upregulation of a specific subset of genes encoding protein-folding chaperones. Blm10 loss or truncation of the Ubp3/Blm3 deubiquitinating enzyme caused massive chromosomal damage and cell death in homozygous diploids after phleomycin treatments, indicating that Blm10 and Ubp3/Blm3 function to stabilize the genome and protect against cell death. …
Spatial Variability In Levels Of Benzene, Formaldehyde, And Total Benzene, Toluene, Ethylbenzene And Xylenes In New York City: A Land-Use Regression Study, Iyad Kheirbek, Sarah Johnson, Zev Ross, Grant Pezeshki, Kazuhiko Ito, Holger Eisl, Thomas Matte
Spatial Variability In Levels Of Benzene, Formaldehyde, And Total Benzene, Toluene, Ethylbenzene And Xylenes In New York City: A Land-Use Regression Study, Iyad Kheirbek, Sarah Johnson, Zev Ross, Grant Pezeshki, Kazuhiko Ito, Holger Eisl, Thomas Matte
Publications and Research
Background Hazardous air pollutant exposures are common in urban areas contributing to increased risk of cancer and other adverse health outcomes. While recent analyses indicate that New York City residents experience significantly higher cancer risks attributable to hazardous air pollutant exposures than the United States as a whole, limited data exist to assess intra-urban variability in air toxics exposures. Methods To assess intra-urban spatial variability in exposures to common hazardous air pollutants, street-level air sampling for volatile organic compounds and aldehydes was conducted at 70 sites throughout New York City during the spring of 2011. Land-use regression models were developed …
An Integrated Vendor-Buyer Cooperative Inventory Model For Items With Imperfect Quality And Shortage Backordering, Jia-Tzer Hsu, Lie-Fern Hsu
An Integrated Vendor-Buyer Cooperative Inventory Model For Items With Imperfect Quality And Shortage Backordering, Jia-Tzer Hsu, Lie-Fern Hsu
Publications and Research
We develop a model to determine an integrated vendor-buyer inventory policy for items with imperfect quality and planned back orders. The production process is imperfect and produces a certain number of defective items with a known probability density function. The vendor delivers the items to the buyer in small lots of equally sized shipments. Upon receipt of the items, the buyer will conduct a 100% inspection. Since each lot contains a variable number of defective items, shortages may occur at the buyer. We assume that shortages are permitted and are completely back ordered. The objective is to minimize the total …
Utilizing The Reaction Of Degeneration Test For Individuals With Focal Paralysis, Thomas J. Holland
Utilizing The Reaction Of Degeneration Test For Individuals With Focal Paralysis, Thomas J. Holland
Publications and Research
Background and purpose Neuromuscular electrical stimulation (NMES) is a modality sometimes used to help strengthen weak muscles. On occasion, however, the targeted muscles do not respond to the current delivered. No response to electrical stimulation should raise the consideration of unsuspected peripheral nerve damage. Two case studies are presented showing how absence of response was due to unsuspected peripheral neuropathy, which had not been considered in either of the original referral diagnoses. Case descriptions The first individual sustained head trauma and did not respond to NMES to facilitate finger flexor contractions in the left hand. This prompted a reaction of …
Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe
Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe
Publications and Research
Western lifestyles differ markedly from those of our hunter-gatherer ancestors, and these differences in diet and activity level are often implicated in the global obesity pandemic. However, few physiological data for hunter-gatherer populations are available to test these models of obesity. In this study, we used the doubly-labeled water method to measure total daily energy expenditure (kCal/day) in Hadza hunter-gatherers to test whether foragers expend more energy each day than their Western counterparts. As expected, physical activity level, PAL, was greater among Hadza foragers than among Westerners. Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than …
Detecting The Immune System Response Of A 500 Year-Old Inca Mummy, Angelique Corthals, Antonius Koller, Dwight W. Martin, Robert Rieger, Emily I. Chen, Mario Bernaski, Gabriella Recagno, Liliana M. Dávalos
Detecting The Immune System Response Of A 500 Year-Old Inca Mummy, Angelique Corthals, Antonius Koller, Dwight W. Martin, Robert Rieger, Emily I. Chen, Mario Bernaski, Gabriella Recagno, Liliana M. Dávalos
Publications and Research
Disease detection in historical samples currently relies on DNA extraction and amplification, or immunoassays. These techniques only establish pathogen presence rather than active disease. We report the first use of shotgun proteomics to detect the protein expression profile of buccal swabs and cloth samples from two 500-year-old Andean mummies. The profile of one of the mummies is consistent with immune system response to severe pulmonary bacterial infection at the time of death. Presence of a probably pathogenic Mycobacterium sp. in one buccal swab was confirmed by DNA amplification, sequencing, and phylogenetic analyses. Our study provides positive evidence of active pathogenic …
Remarks Of President Jeremy Travis On Receipt Of The Maud Booth Correctional Services Award From The Volunteers Of America, Jeremy Travis
Remarks Of President Jeremy Travis On Receipt Of The Maud Booth Correctional Services Award From The Volunteers Of America, Jeremy Travis
Publications and Research
No abstract provided.
Correlation Of Trpgly And Glytrp Rotamer Structure With W7 And W10 Uv Resonance Raman Modes And Fluorescence Emission Shifts, Azaria Solomon Eisenberg, Laura J. Juszczak
Correlation Of Trpgly And Glytrp Rotamer Structure With W7 And W10 Uv Resonance Raman Modes And Fluorescence Emission Shifts, Azaria Solomon Eisenberg, Laura J. Juszczak
Publications and Research
Tryptophyl glycine (TrpGly) and glycyl tryptophan (GlyTrp) dipeptides at pH 5.5 and pH 9.3 show a pattern of fluorescence emission shifts with the TrpGly zwitterion emission solely blue shifted. This pattern is matched by shifts in the UV resonance Raman (UVRR) W10 band position and the W7 Fermi doublet band ratio. Ab initio calculations show that the 1340 cm−1 band of the W7 doublet is composed of three modes, two of which determine the W7 band ratios for the dipeptides. Molecular dynamics simulations show that the dipeptides take on two conformations: one with the peptide backbone extended; one with the …
Homicide By Neighborhood: Mapping New York City’S Violent Crime Drop, Preeti Chauhan, Lauren Kois
Homicide By Neighborhood: Mapping New York City’S Violent Crime Drop, Preeti Chauhan, Lauren Kois
Publications and Research
Researchers, scholars, and policymakers interested in the falling rate of violent crime in New York City (NYC) have attempted to pinpoint causes of the welcome trend. Discovering the causes of the city’s crime drop may lead to important lessons for the city itself and may influence policy and practice throughout the state, nation, and perhaps other countries. Researchers have suggested a host of mechanisms that may explain the dramatic decline in violence, but two factors—misdemeanor policing and the transformation of drug markets—continue to receive the most attention. This report focuses on these factors in relation to gun-related homicide rates. It …
A New Body Shape Index Predicts Mortality Hazard Independently Of Body Mass Index, Nir Y. Krakauer, Jesse C. Krakauer
A New Body Shape Index Predicts Mortality Hazard Independently Of Body Mass Index, Nir Y. Krakauer, Jesse C. Krakauer
Publications and Research
Background Obesity, typically quantified in terms of Body Mass Index (BMI) exceeding threshold values, is considered a leading cause of premature death worldwide. For given body size (BMI), it is recognized that risk is also affected by body shape, particularly as a marker of abdominal fat deposits. Waist circumference (WC) is used as a risk indicator supplementary to BMI, but the high correlation of WC with BMI makes it hard to isolate the added value of WC. Methods and Findings We considered a USA population sample of 14,105 non-pregnant adults () from the National Health and Nutrition Examination Survey (NHANES) …
The Bitter Truth About Morality: Virtue, Not Vice, Makes A Bland Beverage Taste Nice, Kendall J. Eskine, Natalie A. Kacinik, Gregory D. Webster
The Bitter Truth About Morality: Virtue, Not Vice, Makes A Bland Beverage Taste Nice, Kendall J. Eskine, Natalie A. Kacinik, Gregory D. Webster
Publications and Research
To demonstrate that sensory and emotional states play an important role in moral processing, previous research has induced physical disgust in various sensory modalities (visual, tactile, gustatory, and olfactory modalities, among others) and measured its effects on moral judgment. To further assess the strength of the connection between embodied states and morality, we investigated whether the directionality of the effect could be reversed by exposing participants to different types of moral events prior to rating the same neutral tasting beverage. As expected, reading about moral transgressions, moral virtues, or control events resulted in inducing gustatory disgust, delight, or neutral taste …
Metformin Modifies The Exercise Training Effects On Risk Factors For Cardiovascular Disease In Impaired Glucose Tolerant Adults, Steven K. Malin, Joy Nightingale, Sung-Eun Choi, Stuart R. Chipkin, Barry Braun
Metformin Modifies The Exercise Training Effects On Risk Factors For Cardiovascular Disease In Impaired Glucose Tolerant Adults, Steven K. Malin, Joy Nightingale, Sung-Eun Choi, Stuart R. Chipkin, Barry Braun
Publications and Research
Impaired glucose tolerant (IGT) adults are at elevated risk for cardiovascular disease (CVD). Exercise or metformin reduce CVD risk, but the efficacy of combining treatments is unclear. To determine the effects of exercise training plus metformin, compared to each treatment alone, on CVD risk factors in IGT adults. Subjects were assigned to: placebo (P), metformin (M), exercise plus placebo (EP), or exercise plus metformin (EM) (8/group). In a double-blind design, P or 2000mg/d of M were administered for 12 weeks and half performed aerobic and resistance training 3 days/week for approximately 60 minutes/day at 70% pre-training heart rate peak. Outcomes …
Ih Modulates Theta Rhythm And Synchrony In Computer Model Of Ca3, Markus M. Hilscher, Thiago Moulin, Yosef Skolnick, William W. Lytton, Samuel A. Neymotin
Ih Modulates Theta Rhythm And Synchrony In Computer Model Of Ca3, Markus M. Hilscher, Thiago Moulin, Yosef Skolnick, William W. Lytton, Samuel A. Neymotin
Publications and Research
No abstract provided.
Reaction-Diffusion Modeling In The Neuron Simulator, Robert A. Mcdougal, Yosef Skolnick, James C. Schaff, William W. Lytton, Michael L. Hines
Reaction-Diffusion Modeling In The Neuron Simulator, Robert A. Mcdougal, Yosef Skolnick, James C. Schaff, William W. Lytton, Michael L. Hines
Publications and Research
No abstract provided.
Increasing Drug Arrests After 1980 Had Disproportionate Effect On Women, Jeffrey A. Butts
Increasing Drug Arrests After 1980 Had Disproportionate Effect On Women, Jeffrey A. Butts
Publications and Research
Drug arrests increased faster for adult women and were nearly double the rate for men of the same age from 1980, though men still outnumber women in this category. This databit shows the arrest rates for women from 1980 to 2010 for youth, young adults, and older adults in drug sales/manufacture and possession.
When Data Are Not Missing At Random: Implications For Measuring Health Conditions In The Behavioral Risk Factor Surveillance System, Martin R. Frankel, Michael P. Battaglia, Lina Balluz, Tara Strine
When Data Are Not Missing At Random: Implications For Measuring Health Conditions In The Behavioral Risk Factor Surveillance System, Martin R. Frankel, Michael P. Battaglia, Lina Balluz, Tara Strine
Publications and Research
Objectives To examine the effect on estimated levels of health conditions produced from large-scale surveys, when either list-wise respondent deletion or standard demographic item-level imputation is employed. To assess the degree to which further bias reduction results from the inclusion of correlated ancillary variables in the item imputation process. Design Large cross-sectional (US level) household survey. Participants 218 726 US adults (18 years and older) in the 2006 Behavioral Risk Factor Surveillance System Survey. This survey is the largest US telephone survey conducted by the Centers for Disease Control and Prevention. Primary and secondary outcome measures Estimated rates of severe …
Implementation As Ongoing And Incremental: Case Study Of Web 2.0 Use For Staff Communication, Wendy Chu
Implementation As Ongoing And Incremental: Case Study Of Web 2.0 Use For Staff Communication, Wendy Chu
Publications and Research
Web 2.0 implementations in academic libraries tend to concentrate on rolling out a functioning system first and training of personnel second. This article offers a case analysis documenting one approach to implementation, whereby a website slowly integrates Web 2.0 technologies in a just-in-time orientation, and the impact on improving staff communication and cultivating community awareness for a small academic library. Findings underscore the need to reexamine the implementation process as a continuous, adaptive, and non-demanding engagement with colleagues and staff based on active awareness of developments and needs.
Inhibition Of Pokeweed Antiviral Protein (Pap) By Turnip Mosaic Virus Genome-Linked Protein (Vpg), Artem V. Domashevskiy, Hiroshi Miyoshi, Dixie J. Goss
Inhibition Of Pokeweed Antiviral Protein (Pap) By Turnip Mosaic Virus Genome-Linked Protein (Vpg), Artem V. Domashevskiy, Hiroshi Miyoshi, Dixie J. Goss
Publications and Research
Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome-inactivating protein (RIP) and an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin loop of large rRNA, arresting protein synthesis at the translocation step. PAP is also a cap-binding protein and is a potent antiviral agent against many plant, animal, and human viruses. To elucidate the mechanism of RNA depurination, and to understand how PAP recognizes and targets various RNAs, the interactions between PAP and turnip mosaic virus genomelinked protein (VPg) were investigated. VPg can function as a cap analog in cap-independent translation and potentially target PAP to uncapped …
Potential Significance Of Photoexcited No2 On Global Air Quality With The Nmmb/Bsc Chemical Transport Model, O. Jorba, D. Dabdub, Christopher S. Blaszczak-Boxe, C. Pérez, Z. Janjic, J. M. Baldasano, M. Spada, A. Badia, M. Gonçalves
Potential Significance Of Photoexcited No2 On Global Air Quality With The Nmmb/Bsc Chemical Transport Model, O. Jorba, D. Dabdub, Christopher S. Blaszczak-Boxe, C. Pérez, Z. Janjic, J. M. Baldasano, M. Spada, A. Badia, M. Gonçalves
Publications and Research
Atmospheric chemists have recently focused on the relevance of the NO2* + H2O → OH + HONO reaction to local air quality. This chemistry has been considered not relevant for the troposphere from known reaction rates until nowadays. New experiments suggested a rate constant of 1.7 × 10−13 cm3 molecule−1 s−1, which is an order of magnitude faster than the previously estimated upper limit of 1.2 × 10−14 cm3 molecule−1 s−1, determined by Crowley and Carl (1997). Using the new global model, NMMB/BSC Chemical Transport Model (NMMB/BSC-CTM), simulations are presented that assess the potential significance of this chemistry on global …
Halogen Activation Via Interactions With Environmental Ice And Snow In The Polar Lower Troposphere And Other Regions, J. P. D. Abbatt, J. L. Thomas, K. Abrahamsson, Chris Boxe, A. Granfors, A. E. Jones, M. D. King, A. Saiz-Lopez, P. B. Shepson, J. Sodeau, D. W. Toohey, C. Toubin, R. Von Glasow, S. N. Wren, X. Yang
Halogen Activation Via Interactions With Environmental Ice And Snow In The Polar Lower Troposphere And Other Regions, J. P. D. Abbatt, J. L. Thomas, K. Abrahamsson, Chris Boxe, A. Granfors, A. E. Jones, M. D. King, A. Saiz-Lopez, P. B. Shepson, J. Sodeau, D. W. Toohey, C. Toubin, R. Von Glasow, S. N. Wren, X. Yang
Publications and Research
The role of ice in the formation of chemically active halogens in the environment requires a full understanding because of its role in atmospheric chemistry, including controlling the regional atmospheric oxidizing capacity in specific situations. In particular, ice and snow are important for facilitating multiphase oxidative chemistry and as media upon which marine algae live. This paper reviews the nature of environmental ice substrates that participate in halogen chemistry, describes the reactions that occur on such substrates, presents the field evidence for ice-mediated halogen activation, summarizes our best understanding of ice-halogen activation mechanisms, and describes the current state of modeling …
Comparing Unique Title Coverage Of Web Of Science And Scopus In Earth And Atmospheric Sciences, Philip Barnett, Claudia Lascar
Comparing Unique Title Coverage Of Web Of Science And Scopus In Earth And Atmospheric Sciences, Philip Barnett, Claudia Lascar
Publications and Research
No abstract provided.
An Author And A Bookshop: Publishing Marlowe’S Remains At The Black Bear, Andras Kisery
An Author And A Bookshop: Publishing Marlowe’S Remains At The Black Bear, Andras Kisery
Publications and Research
Bookshops and the spaces occupied by the early modern book trade have received attention as social environments. This study of the early publication history of Christopher Marlowe's poems -- Hero and Leander, his translation of Lucan, as well as the lyric now known as "The Passionate Shepherd to his Love" -- shows that, the bookshops may also turn out to be agents shaping the fate of books, authors, and literary afterlives. Shifting our emphasis from the individual bookseller to the networks of a plurality of human agents and environments allows us to consider the intersections of various commercial and …
Temporal Changes In Collagen Cross-Links In Spontaneous Articular Cartilage Repair, Masahiko Terajima, Sheela Damle, Madhuri Penmatsa, Paul West, Mathias Bostrom, Chisa Hidaka, Mitsuo Yamauchi, Nancy Pleshko
Temporal Changes In Collagen Cross-Links In Spontaneous Articular Cartilage Repair, Masahiko Terajima, Sheela Damle, Madhuri Penmatsa, Paul West, Mathias Bostrom, Chisa Hidaka, Mitsuo Yamauchi, Nancy Pleshko
Publications and Research
Objective: Little is known about how the biochemical properties of collagen change during tissue regeneration following cartilage damage. In the current study, temporal changes in cartilage repair tissue biochemistry were assessed in a rabbit osteochondral defect. Design: Bilateral full-thickness 3-mm osteochondral trochlear groove defects were created in 54 adult male skeletally mature New Zealand white rabbits, and tissue repair was monitored over 16 weeks. Collagen content, cross-links, lysyl hydroxylation, gene expression, histological grading, and Fourier transform infrared analyses were performed at 2, 4, 6, 8, 12, and 16 weeks. Results: Defect fill occurred at ~4 weeks postinjury; however, histological grading …
In Memoriam: Marta G. Franco, John A. Drobnicki
In Memoriam: Marta G. Franco, John A. Drobnicki
Publications and Research
Marta Franco was the longtime Serials Librarian in the York College Library.