Nuclear Tau, P53 And Pin1 Regulate Parn-Mediated Deadenylation And Gene Expression, Jorge Baquero, Sophia Varriano, Martha Ordonez, Pawel Kuczaj, Michael R. Murphy, Gamage Aruggoda, Devon Lundine, Viktoriya Morozova, Ali Elhadi Makki, Alejandra Del C. Alonso, Frida E. Kleiman

Publications and Research

While nuclear tau plays a role in DNA damage response (DDR) and chromosome relaxation, the mechanisms behind these functions are not fully understood. Here, we show that tau forms complex(es) with factors involved in nuclear mRNA processing such as tumor suppressor p53 and poly(A)-specific ribonuclease (PARN) deadenylase. Tau induces PARN activity in different cellular models during DDR, and this activation is further increased by p53 and inhibited by tau phosphorylation at residues implicated in neurological disorders. Tau’s binding factor Pin1, a mitotic regulator overexpressed in cancer and depleted in Alzheimer’s disease (AD), also plays a role in the activation of …

Citations Needed: Wikidata And The Scholarly Publishing Ecosystem, Megan Wacha

Publications and Research

Since Wikidata’s launch in 2012 as an open, collaboratively edited knowledge base, it’s held great promise for the library and scholarly communication community more broadly. Institutions and individual information professionals turned Wikidatans are using Wikidata to build a community-owned infrastructure for the bibliographic ecosystem, including open source tools that generate profiles of scholars, organizations, and publications. This workshop will introduce participants to Wikidata and its linked data infrastructure, including opportunities for hands-on editing and an overview of tools that facilitate data contribution and use. Participants will leave prepared to connect with existing Wikidata initiatives, and with entry points to launch …

Evaluation Of Approaches For Mapping Tidal Wetlands Of The Chesapeake And Delaware Bays, Brian T. Lamb, Maria A. Tzortziou, Kyle C. Mcdonald

Publications and Research

The spatial extent and vegetation characteristics of tidal wetlands and their change are among the biggest unknowns and largest sources of uncertainty in modeling ecosystem processes and services at the land-ocean interface. Using a combination of moderate-high spatial resolution (

Spatial Upscaling Of Forest Response To Drought, Wei Fang, Peipei Xu, Tao Zhao, Xiang Zhao, Hui Luo, George Hendrey, Chuixiang Yi

Publications and Research

We have integrated the observational capability of satellite remote sensing with plot-scale tree ring data to up-scale the evaluation of forest responses to drought. Satellite data, such as Normalized Difference Vegetation Index (NDVI), can provide a spatially continuous measure with limited temporal coverage, while tree Ring Width Index (RWI) provides accurate assessment with much longer time series local scales. Here, we explored the relationship between RWI and NDVI of three dominant species in the Southwestern United States (SWUS), and predicted RWI spatial distribution from 2001 to 2017 based on MODIS 1-km resolution NDVI data with stringent quality control. We detected …

An Amyloid Core Sequence In The Major Candida Albicans Adhesin Als1p Mediates Cell-Cell Adhesion, Vida Ho, Philippe Herman-Bausier, Christopher Shaw, Karen A. Conrad, Melissa C. Garcia-Sherman, Jeremy Draghi, Yves F. Dufrene, Peter N. Lipke, Jason M. Rauceo

Publications and Research

ABSTRACT The human fungal commensal Candida albicans can become a serious opportunistic pathogen in immunocompromised hosts. The C. albicans cell adhesion protein Als1p is a highly expressed member of a large family of paralogous adhesins. Als1p can mediate binding to epithelial and endothelial cells, is upregulated in infections, and is important for biofilm formation. Als1p includes an amyloidforming sequence at amino acids 325 to 331, identical to the sequence in the paralogs Als5p and Als3p. Therefore, we mutated Val326 to test whether this sequence is important for activity. Wild-type Als1p (Als1pWT) and Als1p with the V326N mutation (Als1pV326N) were expressed …

Tio2/S-Doped Carbons Hybrids: Analysis Of Their Interfacial And Surface Features, Teresa Bandosz, Alfonso Policicchio, Marc Florent, Po S. Poon, Juan Matos

Publications and Research

Hybrids containing approximately equal amounts of P25 TiO2 and S-doped porous carbons were prepared using a water-based slurry mixing method. The materials were extensively characterized by adsorption of nitrogen, potentiometric titration, thermal analysis in air and in helium, XRD, XPS and SEM. The collected results showed the significant blockage of carbon micropores by TiO2 particles deposited on their outer surface. The formation of a new interface, especially for the S-rich samples, might also contribute to the porosity alteration. Analysis of surface chemistry suggested the presence of Ti-S bonds with an involvement of sulfur from thiophenic species in the carbon phase. …

Promoting Science Through The Arts (Or Vice Versa)., Aldemaro Romero Jr.

Publications and Research

Higher Education has a problem with the arts. In a sector that is increasingly serving first-generation students who come from lower-income families, the pressure to provide a path towards secure, well-paid jobs is on. That is particularly true in this time and age of political pressure upon public institutions of higher education to emphasize STEM (Science, Technology, Engineering and Mathematics) careers rather than the liberal arts (visual and performing arts, humanities, even social sciences) with the stereotype that if you become something like an artist or a poet you are more likely to end up being underemployed at best or …

Cytotoxic Xanthones From Hypericum Stellatum, An Ethnomedicine In Southwest China, Yuanyuan Ji, Ruifei Zhang, Chen Zhang, Xingyu Li, Adam Negrin, Chaonan Yuan, Edward J. Kennelly, Chunlin Long

Publications and Research

Hypericum stellatum, a species endemic to China, is used to treat hepatitis by several ethnic groups in Guizhou Province. This research was inspired by the traditional medicinal usage of H. stellatum, and aims to explore the phytochemistry and bioactivity of H. stellatum to explain why local people in Guizhou widely apply H. stellatum for liver protection. In this study, two new prenylated xanthones, hypxanthones A (8) and B (9), together with seven known compounds, were isolated from the aerial parts of the plant. Spectroscopic data as well as experimental and calculated ECD spectra were used to establish the structures of …

Evaluation Of Mitral Apparatus Blood Cyst: A Case Report And Review Of Literature, Dipesh Ludhwani, Belaal Sheikh, Yahya Sheikh

Publications and Research

Intracardiac blood cysts (ICBC) are cardiac pseudoneoplasm commonly seen in infants below two months of age. ICBC typically resolve spontaneously; however, they can sometimes persist in adults and can cause detrimental consequences. A 47-year-old female presented to our facility with complaints of chest pain and was found to have an incidental subvalvular chordal mitral apparatus echolucent mass on transthoracic echocardiogram (TTE). A stress echocardiography was performed, which revealed transient left ventricle outflow tract (LVOT) obstruction in the absence of anginal symptoms. A cardiac magnetic resonance imaging (MRI) showed no evidence of increased mass enhancement confirming the diagnosis of a benign …

Fake News Poetry Workshop As Radical Digital Media Literacy: It’S For The Thing We’Re Not Yet,, Alexandra Juhasz

Publications and Research

One of 17 saddle stitched pamphlets + custom designed box

What does pedagogy mean to your writing practice? How do your poetics intersect with your pedagogy and education commitments? We invited participants to join together to think about the inventive and urgent possibilities of intertwined poetic-pedagogical work. What might emerge differently when we bring them together?

Urgent Possibilities, Writings on Feminist Poetics & Emergent Pedagogies grew out of the Feminist Poetics, Emergent Pedagogies Symposium organized by Andrea Quaid and Margaret Rhee. The publication collects work by symposium participants with documents and elaborations, including poems, poetic tracts, essays, workshop plans, and …

Addressing Extremism Through Literature: An Online Cross-Cultural Conversation On Mahi Binebine's Horses Of God, Habiba Boumlik, Phyllis E. Vanslyck

Publications and Research

In the Fall of 2017, first year liberal arts students at Community College and second year Masters’ Students in literature at a university in Morocco collaborated in an online and live conversation focusing on the novel Horses of God (Les Etoiles de Sidi Moumen) written by Mahi Binebine. The novel describes the lives of four childhood friends growing up in a slum near Casablanca, navigating poverty and purposelessness and being drawn to religious fundamentalism. Students in the two colleges engaged in an online discussion on Facebook and live Google Hangouts exchange in which they shared questions about the …

Lingering Over The Hate And Denial In Response To A Letter To White America, Gordon Alley-Young

Publications and Research

No abstract provided.

Curation And Independent Record Shops, Lee Ann Fullington

Publications and Research

No abstract provided.

The Making And Silencing Of “Axé-Ocracy” In Brazil: Black Women Writers’ Spiritual, Political And Literary Movement In São Paulo, Sarah S. Ohmer

Publications and Research

In this article, I will focus on two influential writers from the south of Brazil, Cristiane Sobral who currently lives in Brasília, from Rio de Janeiro, and Conceição Evaristo who currently lives in Rio de Janeiro state, from Minas Gerais. I got to know them in São Paulo in 2015 at a public event: the “Afroétnica Flink! Sampa Festival of Black Thought, Literature and Culture.” I will include references to some of their younger contemporaries such as Raquel Almeida, Jenyffer Nascimento, and Elizandra Souza, all of whom reside in São Paulo, in order to illustrate the Black Brazilian women writers’ …

Digital Collaborations: A Survey Analysis Of Digital Humanities Partnerships Between Librarians And Other Academics, Jessica Wagner Webster

Publications and Research

The present study will investigate the perceptions of information professionals about their role in the work of digital humanities scholars, as well as the perceptions of digital humanities scholars on the role of information professionals in their research. While other scholarly literature has considered collaborations between these groups via surveys or interviews with small project teams, the present study will provide a large-scale analysis of collaborations using survey responses from more than 500 scholars, librarians, and archivists. Questions sought to determine the extent to which these groups collaborate with one another on project teams; how these collaborations unfold and who …

Dressed To Impress: The Effect Of Victim Attire On Helping Behavior, Sergio W. Carvalho, Diogo Hildebrand, Sankar Sen

Publications and Research

Charitable organizations often rely on pictures of victims to raise support for their causes. We examine the effect of donor perceptions of a novel aesthetic element of a victim’s physical appearance – his/her attire – on helping. In line with our theorizing, a field study, a survey and an experiment, together, show that donor perceptions that a victim is well attired reduces helping by diminishing her perceived need. Moreover, we show that this negative effect of neat attire on helping behavior is weaker for more physically attractive victims than for their less attractive counterparts. These findings establish a victim’s attire …

Foreword: Libraries Promoting Reflective Dialogue In A Time Of Political Polarization, Jonathan Cope

Publications and Research

Foreword to the ACRL book Libraries Promoting Reflective Dialogue in a Time of Political Polarization.

Create A Revolution In Undergraduates' Understanding Of Science: Teach Through Close Analysis Of Scientific Literature, Sally G. Hoskins

Publications and Research

The teaching of science to undergraduates aligns poorly with the practice of science, leading many students to conclude that research is boring and researchers themselves are antisocial geniuses. Creativity, a key driver of scientific progress, is underemphasized or ignored altogether in many classrooms, as teaching focuses on the complex integrated concepts and voluminous amounts of information typical of STEM curricula. Faculty, largely untrained in science education per se, teach largely as they were taught, through lectures based in textbooks. This situation could change, and students' understanding of research practice could be fostered relatively easily, if faculty began teaching classes focused …

Medical Dental Device: Biogeneric Implant Prototype, Ibeth Erazo, Aneeza Hussain, Renata Budny, Gaffar Gailani

Publications and Research

Teeth are lost due to tooth decay, injury, disease, or other causes. Today, dental implants extend the range of care to a variety of patients undergoing necessary prosthodontic rehabilitation. If the benefits of such treatments are to be maximized, then implants must be selected on logical basis and placed within the context of the full range of treatment modalities. However, modern dental implant systems are based on multiple components often leading to micro-movements which cause stress on the bone or bacterial infections, both of which compromise the success of osseointegration and consequently jeopardize the whole implant adaptation. Thus, a new …

“Our Stories”: First-Year Learning Communities Students Reflections On The Transition To College, Karen Goodlad, Sandra Cheng, Jennifer Sears, Mery Diaz, Ashwin Satyanarayana, Phil Freniske

Publications and Research

Analysis of diverse first-year and first-generation learning communities students’ reflective narratives shows this population of students at an urban commuter college of technology face significant challenges in the transition into college. Designed to assist in this transition, the “Our Stories” digital writing project incorporates reflective writing in the long established, yet recently revitalized, learning communities program. Through analysis of the “Our Stories” project, we examine how the structure of our learning communities program, together with writing on an open digital platform, builds community and has the potential to positively influence students as they identify, and begin to make sense, of …

The Personal Is Historical: Slavery, Black Power And Resistance In Octavia Butler’S Kindred, Megan Behrent

Publications and Research

No abstract provided.

The Housing Crisis And The Rise Of The Real Estate State, Samuel Stein

Publications and Research

This article — an excerpt from my book, Capital City, with elaborations on a number of key points — argues that the housing crises endemic to contemporary capitalism must be understood as a result of the concentration of global capital into real estate and the the re-orientation of state planning capacities around the demands of the real estate industry. The first half of the article explains the dimensions of the crisis in the US and the rise of "the real estate state." The second half explores policy alternatives to contemporary urban neoliberalism and the kinds of movements necessary to …

Special Issue Introduction: Labor In Academic Libraries, Emily Drabinski, Aliqae Geraci, Roxanne Shirazi

Publications and Research

Labor in academic libraries has reemerged as an area of critical interest in both academic library and archives communities. Librarians and archivists have long worked to counter the diminishment of their labor within an academy that centers the concerns of disciplinary faculty who may, in turn, see knowledge workers as a footnote to the scholarly enterprise. Recent years have seen a renewed attention to the social and economic conditions of our work, as researchers turned to topics such as affective labor in libraries and archives, attitudes toward labor unions, and information work under capitalism (Sloniowski 2016; Mills and McCullough 2018; …

Developing Open Practices In Teacher Education: An Example Of Integrating Oer And Developing Renewable Assignments, Jennifer Van Allen, Stacy Katz

Publications and Research

This manuscript offers a reasoning for and example of integrating Open Educational Resources (OER) and open pedagogy within a teacher education course. We highlight a collaborative partnership between library faculty and education faculty and the decision points and processes we used when redesigning this course to provide an example of adopting OER and our considerations for developing a renewable assignment. The benefits of using OER for K-12 teachers include increasing awareness of and providing opportunities to develop open practices. The transition to a renewable assignment creates a space for teaching candidates to meaningfully contribute to the profession and engage in …

Temporal Changes In Abundance–Occupancy Relationships Over 40 Years, Lisa L. Manne, Richard R. Veit

Publications and Research

1. Abundance–occupancy (A–O) relationships are widely documented for many organismal groups and regions, and have been used to gain an understanding of regional population and community trends. Monitoring changes in abundance and occupancy over time may be what is required to document changes in conservation status and needs for some species, communities, or areas.
2. We hypothesize that if there is a higher proportion of declining species in one group of species compared with another (e.g., migratory species vs. permanent residents), then a consequence of that difference will be vastly different abundance–occupancy relationships. If this difference persists through time, then the resulting …

Stretchable Piezoelectric Power Generators Based On Zno Thin Films On Elastic Substrates, Ioana Voiculescu, Fang Li, Glen Kowach, Nicolas Mistou, Russell Kastberg

Publications and Research

The paper describes a stretchable, microfabricated power generator that will be attached on the skin and will produce energy based on the movements of the human body. The device was fabricated on a polymeric, elastomeric, poly(dimethylsiloxane) (PDMS) sheet. It consists of a piezoelectric thin film of ZnO sandwiched between two stretchable gold electrodes. An innovative technique was used for the deposition of ZnO thin film on the gold electrode-coated polymeric substrate at low temperatures below 150C. This is the first attempt to use a uniform film of ZnO, for energy harvesting. The ZnO film had the thickness at the submicron …

Inclusion Of Enclosed Hydration Effects In The Binding Free Energy Estimation Of Dopamine D3 Receptor Complexes, Rajat Kumar Pal, Satishkumar Gadhiya, Steven Ramsey, Pierpaolo Cordone, Lauren Wickstrom, Wayne W. Harding, Tom Kurtzman, Emilio Gallicchio

Publications and Research

Confined hydration and conformational flexibility are some of the challenges encountered for the rational design of selective antagonists of G-protein coupled receptors.We present a set of C3-substituted (-) -stepholidine derivatives as potent binders of the dopamine D3 receptor.The compounds are characterized biochemically, as well as by computer modeling using a novel molecular dynamics-based alchemical binding free energy approach which incorporates the effect of the displacement of enclosed water molecules from the binding site.The free energy of displacement of specific hydration sites is obtained using the Hydration Site Analysis method with explicit solvation. This work underscores the critical role of confined …

Bright Green Biofluorescence In Sharks Derives From Bromo-Kynurenine Metabolism, Hyun Bong Park, Yick Chong Lam, Jean P. Gaffney, James C. Weaver, Sara Rose Krivoshik, Randy Hamchand, Vincent Pieribone, David F. Gruber, Jason M. Crawford

Publications and Research

Although in recent years there has been an increased awareness of the widespread nature of biofluorescence in the marine environment, the diversity of the molecules responsible for this luminescent phenotype has been mostly limited to green fluorescent proteins (GFPs), GFP-like proteins, and fluorescent fatty acid-binding proteins (FABPs). In the present study, we describe a previously undescribed group of brominated tryptophan-kynurenine small molecule metabolites responsible for the green biofluorescence in two species of sharks and provide their structural, antimicrobial, and spectral characterization. Multi-scale fluorescence microscopy studies guided the discovery of metabolites that were differentially produced in fluorescent versus non-fluorescent skin, as …

Precipitation Trends Over The Indus Basin, Nir Krakauer, Tarendra Lakhankar, Ghulam Hussain Dars

Publications and Research

A large population relies on water input to the Indus basin, yet basinwide precipitation amounts and trends are not well quantified. Gridded precipitation data sets covering different time periods and based on either station observations, satellite remote sensing, or reanalysis were compared with available station observations and analyzed for basinwide precipitation trends. Compared to observations, some data sets tended to greatly underestimate precipitation, while others overestimate it. Additionally, the discrepancies between data set and station precipitation showed significant time trends in many cases, suggesting that the precipitation trends of those data sets were not consistent with station data. Among the …

Repeated Transspinal Stimulation Decreases Soleus H-Reflex Excitability And Restores Spinal Inhibition In Human Spinal Cord Injury, Maria Knikou, Lynda M. Murray

Publications and Research

Transcutaneous spinal cord or transspinal stimulation over the thoracolumbar enlargement, the spinal location of motoneurons innervating leg muscles, modulates neural circuits engaged in the control of movement. The extent to which daily sessions (e.g. repeated) of transspinal stimulation affects soleus H-reflex excitability in individuals with chronic spinal cord injury (SCI) remains largely unknown. In this study, we established the effects of repeated cathodal transspinal stimulation on soleus H-reflex excitability and spinal inhibition in individuals with and without chronic SCI. Ten SCI and 10 healthy control subjects received monophasic transspinal stimuli of 1-ms duration at 0.2 Hz at subthreshold and suprathreshold …