Digital Commons Network^™

Me3al-Mediated Domino Nucleophilic Addition/Intramolecular Cyclisation Of 2-(2-Oxo-2-Phenylethyl)Benzonitriles With Amines; A Convenient Approach For The Synthesis Of Substituted 1-Aminoisoquinolines, Krishna M. S. Adusumalli, Lakshmi N.S. Konidena, Hima B. Gandham, Krishnaiah Kumari, Krishan R. Valluru, Satya K.R. Nidasanametla, Venkateswara R. Battula, Hari K. Namballa

Publications and Research

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2- phenylethyl)benzonitriles with amines in the presence of Me 3 Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good func- tional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the anti- tumor agent CWJ-a-5 in gram scale.

Spotlight Report #3: Me2b Alliance Validation Research: Consumer Sensitivity To Location Tracking By Websites And Mobile App, Noreen Y. Whysel, Karina Alexanyan

Publications and Research

This research was conducted to validate the Location Commitment scoring criteria in the Me2B Alliance Respectful Technology Specification. The objective of the study was to understand if the requirements and passing criteria of select location tests in the Me2BA Respectful Technology Specification are appropriate. Toward that end, we conducted quantitative and qualitative studies of consumer perception and tolerance for location awareness by digital technologies. The studies explored participant understanding of what a location request is, how consumers feel about such awareness, and what are the specific parameters and scenarios that make location awareness acceptable.

The core of the research was …

How Can I Get Covid?: Understanding Diferences In American Heterosexual And Sexual Minority Men’S Risk Perception, Devon M. Price, Amanda N. Gesselman, Rachel A. Fikslin, Alison J. Goldberg, Omaima Pervez, Mora A. Reinka, Elissia Franklin

Publications and Research

Men are more vulnerable to COVID-19 infections compared to women, but their risk perceptions around COVID-19 are persis - tently lower. Further, men often engage in less health promotion behavior because self-care in this capacity is seen as weak or less masculine. This combination has consequences for mortality; thus, a better understanding of men’s COVID-19 cognitions and individual diference factors is critical. In a web-based survey conducted during the beginning stages of the pandemic in the U.S., we collected risk perceptions of various sexual and non-sexual behaviors from heterosexual ( n = 137) and gay/bisexual men ( n = 108). …

Inverse Kinematics Of The 6dof C12xl, Carl Liu, Lili Ma

Publications and Research

Industrial robotic manipulators are widely used in applications such as pick & place, welding, and assembly to perform repeated tasks in replace of human labor. Such tasks typically require fully autonomous mechanical arms that are capable of identifying the parts to operate, path planning, and trajectory generation & tracking. A robotic arm consists of a sequence of rigid links connected by movable components (the joints). Proper control of the arm’s motion requires the knowledge of inverse kinematics, which computes/outputs the joint variables, i.e., angles for revolute joints and displacement for prismatic joints, causing the robotic arm’s end effector (e.g., gripper, …

Treatment Selection Using Prototyping In Latent-Space With Application To Depression Treatment, Akiva Kleinerman, Ariel Rosenfeld, David Benrimoh, Robert Fratila, Caitrin Armstrong, Joseph Mehltretter, Eliyahu Shneider, Amit Yaniv-Rosenfeld, Jordan Karp, Charles F. Reynolds, Gustavo Turecki, Adam Kapelner

Publications and Research

Machine-assisted treatment selection commonly follows one of two paradigms: a fully personalized paradigm which ignores any possible clustering of patients; or a sub-grouping paradigm which ignores personal differences within the identified groups. While both paradigms have shown promising results, each of them suffers from important limitations. In this article, we propose a novel deep learning-based treatment selection approach that is shown to strike a balance between the two paradigms using latent-space prototyping. Our approach is specifically tailored for domains in which effective prototypes and sub-groups of patients are assumed to exist, but groupings relevant to the training objective are not …

Participatory Budgeting: A Librarian’S Experience, John P. Delooper

Publications and Research

This article discusses one librarian’s experience with the Participatory Budgeting process in New York City. It includes information about how New York’s Participatory Budgeting process works, as well as Participatory Budgeting’s principles, and some discussion of how libraries have utilized PB. In addition, it includes discussion of how librarian skillsets can be especially useful for participatory budgeting.

Always Create A Plan: Everyday Project Management For Professionals, Robin Naughton

Publications and Research

Think about all the things you have to do in a day, whether for work or play.

Think about all the ways you have to do that thing whether simple or complex.

Think about all the resources you have or don’t have, whether it is money, people, places or things.

Think about all the time you have, whether it is a minute or a day.

Now, plan how you will get it all done today or tomorrow or by a due date.

This is project management! This is every day and for everyone.

When we think about project management, sometimes …

Type Vi Secretion System Mutations Reduced Competitive Fitness Of Classical Vibrio Cholerae Biotype, Benjamin Kostiuk, Francis J. Santoriello, Laura Diaz-Satizabal, Fabiana Bisaro, Kyung-Jo Lee, Anna N. Dhody, Daniele Provenzano, Daniel Unterweger, Stefan Pukatzki

Publications and Research

The gram-negative bacterium Vibrio cholerae is the causative agent of the diarrhoeal disease cholera and is responsible for seven recorded pandemics. Several factors are postulated to have led to the decline of 6th pandemic classical strains and the rise of El Tor biotype V. cholerae, establishing the current 7th pandemic. We investigated the ability of classical V. cholerae of the 2nd and 6th pandemics to engage their type six secretion system (T6SS) in microbial competition against non-pandemic and 7th pandemic strains. We report that classical V. cholerae underwent sequential mutations in T6SS genetic determinants that initially exposed 2nd pandemic strains …

Changes In Utilization Of Birth Control And Prep During Covid‑19 In The Usa: A Mixed‑Method Analysis, Rachel A. Fikslin, Alison J. Goldberg, Amanda N. Gesselman, Mora A. Reinka, Omaima Pervez, Elissia T. Franklin, Olivia Ahn, Devon M. Price

Publications and Research

In the USA, the COVID-19 pandemic has created challenges beyond the direct consequences of the infection. Because of shifting resources in response to need, many domains within the healthcare sector unrelated to COVID-19 have had inter - rupted abilities to provide care. In the current study, we focus on preventative sexual health care during the pandemic. In a sample of 511 (mean age = 27.7) people, we examined quantitative data regarding continuation and discontinuation of birth control and PrEP during the pandemic, along with qualitative data illustrating the underlying reasons for participants’ (dis) continuation. Results showed that most (92.5%) of …

The Temperature-Dependent Conformational Ensemble Of Sars-Cov-2 Main Protease (Mpro), Ali Ebrahim, Blake T. Riley, Desigan Kumaran, Babak Andi, Martin R. Fuchs, Sean Mcsweeney, Daniel A. Keedy

Publications and Research

The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or M^pro, is a promising target for development of novel antiviral therapeutics. Previous X-ray crystal structures of M^pro were obtained at cryogenic temperature or room temperature only. Here we report a series of high-resolution crystal structures of unliganded M^pro across multiple temperatures from cryogenic to physiological, and another at high humidity. We interrogate these datasets with parsimonious multiconformer models, multi-copy ensemble models, and isomorphous difference density maps. Our analysis reveals a temperature-dependent conformational landscape for M^pro, including …

The Effect Of Body Mass Index On Brain Volume And Cognitive Function In Relapsing – Remitting Multiple Sclerosis: A Combirx Secondary Analysis, Aliza Bitton Ben-Zacharia, Malvin N. Janal, Abraham A. Brody, Jerry Wolinsky, Fred Lublin, Gary Cutter

Publications and Research

BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease leading to physical, emotional and cognitive disability. High body mass index (BMI) may impact cognitive function and brain volume in MS. Yet, there is paucity of evidence addressing the impact of BMI on cognitive function and brain volume in MS.

OBJECTIVES: The purpose of this study was to examine the effects of BMI on normal appearing brain volume and cognitive function in patients with relapsing – remitting MS.

METHODS: A secondary data analysis of the NIH CombiRx study was conducted. Multivariate regression and mixed model analyses were executed to analyze …

Impact Of Forensic Medical Evaluations On Immigration Relief Grant Rates And Correlates Of Outcomes In The United States., Holly G. Atkinson, Katarzyna Wyka, Kathryn Hampton, Christian Seno, Elizabeth Yim, Deborah Ottenheimer, Nermeen Arastu

Publications and Research

The purpose of this study was to investigate the impact of forensic medical evaluations on grant rates for applicants seeking immigration relief in the United States (U.S.) and to identify significant correlates of grant success. We conducted a retrospective analysis of 2584 cases initiated by Physicians for Human Rights between 2008-2018 that included forensic medical evaluations, and found that 81.6% of applicants for various forms of immigration relief were granted relief, as compared to the national asylum grant rate of 42.4%. Among the study’s cohort, the majority (73.7%) of positive outcomes were grants of asylum. A multivariable regression analysis revealed …

An Innovative Approach For Integrating Mandatory, Longitudinal Spirituality Training Into The Medical School Curriculum, David W. Fleenor, Holly G. Atkinson, Reena Karani, Susan Lerner, Staci Leisman, Deborah Marin

Publications and Research

Problem:

Most Americans indicate they are religious and/or spiritual and wish to have their beliefs taken into account when engaging with health care providers, yet gaps in medical education and health care practice remain. To underscore the importance of spirituality as a significant social determinant of health, a team at the Icahn School of Medicine at Mount Sinai in New York developed mandatory spirituality and health training for students integrated into all 4 years of the undergraduate medical education curriculum.

Approach:

From 2014 to 2020, a small group of faculty took an innovative approach, launching the initiative and expanding the …

Changes In Histone H3 Acetylation On Lysine 9 Accompany Aβ 1-40 Overexpression In An Alzheimer’S Disease Yeast Model, Muna M. Hugais, Samantha N. Cobos, Seth A. Bennett, Jailene Paredes, Genevieve Foran, Mariana P. Torrente

Publications and Research

Alzheimer’s Disease (AD), the most common type of dementia, is a neurodegenerative disease characterized by plaques of amyloid-beta (Aβ) peptides found in the cerebral cortex of the brain. The pathological mechanism by which Aβ aggregation leads to neurodegeneration remains unknown. Interestingly, genetic mutations do not explain most AD cases suggesting that other mechanisms are at play. Epigenetic mechanisms, such as histone post-translational modifications (PTMs), may provide insight into the development of AD. Here, we exploit a yeast Aβ overexpression model to map out the histone PTM landscape associated with AD. We find a modest decrease in the acetylation levels on …

An Examination Of Coping Strategies And Intent To Leave Child Welfare During The Covid 19 Pandemic, Francie J. Julien‑Chinn, Colleen C. Katz, Eden Wall

Publications and Research

Child welfare work is inherently difficult, and child welfare agencies are known to experience high rates of turnover. We sought to expand the existing literature on intention to leave one’s child welfare agency and commitment to child welfare work through examining the coping mechanisms of frontline workers. Having and utilizing healthy coping mechanisms has proved beneficial to child welfare workers in previous research. In this paper, we examine specific coping mechanisms identifed in the Comprehensive Organizational Health Assessment and how they were associated with child welfare workers’ intent to leave their agency and their commitment to remain in the field …

Vhs Archives, Committed Media Praxis, And ‘Queer Cinema', Alexandra Juhasz

Publications and Research

Committed media praxis is a doing as much as it is a knowing. Queerness is a manner of being as much as it is a politics, theory, or set of modish objects. This chapter about topics that are also processes—queer, media praxis, cinema—performs these across two acts: “Part 1: A Hesitant or Maybe Just Slightly Defiant Preamble,” is a creative unfolding, in the body of the text and as much so in its footnotes, of the author’s “queer feminist media praxis”: “Part 2: VHS Archives” is a demonstration of VHS Archives, a multi-sited, many-yeared project in experimental pedagogy, web-based archival …

Connection Failure: War, Spiritualism And Communications Media In Violet Hunt's "Love's Last Leave.", Melissa Dinsman, Heather M. Robinson

Publications and Research

An overlooked figure of modernist circles, Violent Hunt was a suffragette, novelist, and author of ghost stories. In her second collection of haunted narratives, More Tales of The Uneasy (1925), Hunt explores the ghostliness of the Great War, both for those on the front and at home. In this essay, we focus on the third story in this volume, “Love’s Last Leave,” and argue that Hunt includes both ghost story tropes and communications media to articulate the real deadliness of the Great War. Communications technology and spiritualism share a similar historical evolution, and in “Love’s Last Leave” both types …

A New Morning In Higher Education Collective Bargaining, 2013-2019, William A. Herbert

Publications and Research

This book chapter appears in Julius, D. J. (ed.), Collective Bargaining in Higher Education: Best Practices for Promoting Collaboration, Equity, and Measurable Outcomes (Routledge, New York and London). The chapter analyzes and contextualizes data concerning the growth in unionization and collective bargaining involving faculty, postdoctoral scholars, and graduate assistants from 2013 to 2019, the period between the economic fallout from the Great Recession and the consequences of the COVID-19 pandemic. It discusses the democratic values underlying collective bargaining and the historical and legal development of unionization at public and private institutions over the decades. It identifies three significant new trends …

A Review Of Camera Scanning Apps For You And Your Patrons, John P. Delooper

Publications and Research

This article discusses mobile phone apps that can be used to scan photos and documents via the digital cameras built into smartphones. It talks about the history of these apps and what their best utility is in library settings. It also examines one specific project to digitize materials for a local history website.

Late Pleistocene And Early Holocene Sea-Level History And Glacial Retreat Interpreted From Shell-Bearing Marine Deposits Of Southeastern Alaska, Usa, James F. Baichtal, Alia J. Lesnek, Risa J. Carlson, Nicholas S. Schmuck, Jane L. Smith, Dennis J. Landwehr, Jason P. Briner

Publications and Research

We leverage a data set of >720 shell-bearing marine deposits throughout southeastern Alaska (USA) to develop updated relative sea-level curves that span the past ~14,000 yr. This data set includes site location, elevation, description when avail-able, and 436 14C ages, 45 of which are published here for the first time. Our sea-level curves suggest a peripheral forebulge developed west of the retreating Cordilleran Ice Sheet (CIS) margin between ca. 17,000 and 10,800 calibrated yr B.P. By 14,870 ± 630 to 12,820 ± 340 cal. yr B.P., CIS mar-gins had retreated from all of southeastern Alaska’s fjords, channels, and passages. At …

Health Inequality Analysis In Europe: Exploring The Potential Of The Eq-5d As Outcome, Inge Spronk, Juanita A. Haagsma, Erica I. Lubetkin, Suzanne Polinder, M F. Janssen, G J. Bonsel

Publications and Research

Objective: This study explored the additive value of the multi-item EuroQol 5-Dimension 5-Level (EQ-5D-5L) as an outcome measure in health inequality analyses, relative to the single-item EuroQol visual analog scale (EQ VAS).

Methods: A sample comprising the general population from Italy, the Netherlands, and United Kingdom (UK) completed the EQ-5D-5L and the EQ VAS. The level of education was selected as a proxy for socio-economic status (SES). EQ-5D-5L level sum scores (LSS) were compared against EQ VAS scores. Stratified and multivariable analyses were used to study the associations between SES and the LSS/EQ VAS relative to the presence of chronic …

We Are Each Other’S Breath: Tracing Interdependency Through Critical Poetic Inquiry, Karen Zaino, Jordan Bell

Publications and Research

In this paper, we utilize poetic methods that seek to surface, but not overdetermine, the unanticipated relational excess produced through literacy practices. Karen, a queer white woman, and Jordan, a cis-gendered heterosexual Black man, wrote a series of letters to one another throughout the Spring 2020 semester. We turned to critical poetic inquiry to analyze the letters, interested in poetry’s capacity to highlight literacy’s critical power and its emergent potential. We found ourselves implicated in each other’s lives in new ways; we found our relationship both strengthened and tested. Such relational indeterminacy creates methodological challenges in literacy research. We found …

Resilience And Urban Regeneration Policies. Lessons From Community-Led Initiatives. The Case Study Of Canfugarolas In Mataro (Barcelona), Diego Saez Ujaque, Elisabet Roca, Rafael De Balanzó Joue, Pere Fuertes, Pilar Garcia-Almirall

Publications and Research

This paper addresses socio-ecological, community-led resilience as the ability of the urban system to progress and adapt. This is based on the socio-cultural, self-organized case study of CanFugarolas in Mataró (Barcelona), for the recovery of a derelict industrial building and given the lack of attention to resilience emerging from grassroots. Facing rigidities (stagnation) observed under the provisions of urban regeneration policies (regulatory realm), evidenced in the proliferation of urban voids (infrastructural arena), the social subsystem stands as the enabler of urban progression. Under the heuristics of the Adaptive Cycle and Panarchy, the study embraces Fath’s model to analyze the transition …

Engaging Students About Race: Opportunities For Cross-Campus Partnerships During Black History Month, Mark Aaron Polger, Amy F. Stempler

Publications and Research

No abstract provided.

Teaching Artificial Intelligence In Technology And Engineering Education, Euisuk Sung

Publications and Research

No abstract provided.

Cryo-Em Structure Of Mechanosensitive Channel Ynai Using Sma2000: Challenges And Opportunities, Claudio Catalano, Danya Ben-Hail, Weihua Qiu, Paul Blount, Amedee Des Georges, Youzhong Guo

Publications and Research

Mechanosensitive channels respond to mechanical forces exerted on the cell membrane and play vital roles in regulating the chemical equilibrium within cells and their environment. Highresolution structural information is required to understand the gating mechanisms of mechanosensitive channels. Protein-lipid interactions are essential for the structural and functional integrity of mechanosensitive channels, but detergents cannot maintain the crucial native lipid environment for purified mechanosensitive channels. Recently, detergent-free systems have emerged as alternatives for membrane protein structural biology. This report shows that while membrane-active polymer, SMA2000, could retain some native cell membrane lipids on the transmembrane domain of the mechanosensitive-like YnaI channel, …

Psychosocial Factors Associated With Mask-Wearing Behavior During The Covid-19 Pandemic, Cliff (Yung-Chi) Chen, Mengjia Lei

Publications and Research

Although increasing evidence has supported the efficacy of masks to prevent the spread of the coronavirus (COVID-19), inconsistent and noncompliant mask-wearing behavior has been observed among members of the society. Because mask-wearing is often considered a social contract, it is important to understand the psychosocial factors that influence people’s mask-wearing behavior in order to implement the necessary steps to respond to the pandemic. Based on the protection motivation theory (PMT), this study examined the cognitive factors (threat and coping appraisals) that contribute to mask-wearing behavior and the intention to engage in health protective behavior until the end of the pandemic. …

Dietary Diversity And Nutrient Intake Of Han And Dongxiang Smallholder Farmers In Poverty Areas Of Northwest China, Zhuo Wang, Youhai Chen, Shihua Tang, Siqi Chen, Shaoqing Gong, Xinyin Jiang, Liang Wang, Ying Zhang

Publications and Research

This study aimed to evaluate the status of dietary diversity and nutrient intake among Han and Dongxiang smallholder farmers in poor rural areas of northwest China. In this cross-sectional study, dietary intake was assessed in 499 smallholder farmers aged 18–75 years from two nationally designated impoverished counties in Gansu Province, China, using three consecutive 24 h dietary recalls. The dietary diversity score (DDS) and nutrient adequacy ratio (NAR) were adopted to assess dietary diversity and micronutrient adequacy, respectively. The mean DDS (range from 1 to 9) in participants was relatively low (3.81 ± 1.01). Consumption of grains was excessive, while …

Adverse Childhood Experiences Distinguish Violent Juvenile Sexual Offenders’ Victim Typologies, Michael T. Baglivio, Kevin T. Wolff

Publications and Research

Juvenile perpetrators account for over 25% of all sexual offenses, and over one-third of such offenses are against victims under the age of 18. Given empirical connections between adverse childhood experience (ACE) exposure and perpetration of violence, we create victim typologies based on the juveniles’ relationship to their victims among 5539 justice-involved adolescents who have committed violent against-person sexual felonies. Multinomial logistic regression is used to assess which covariates, including individual ACE exposures and cumulative traumatic exposures, are associated with victim typologies. This approach allows for better targeting of violence prevention efforts, as a more nuanced understanding of the increased …

Dataset Of Concurrent Eeg, Ecg, And Behavior With Multiple Doses Of Transcranial Electrical Stimulation, Nigel Gebodh, Zeinab Esmaeilpour, Abhishek Datta, Marom Bikson

Publications and Research

We present a dataset combining human-participant high-density electroencephalography (EEG) with physiological and continuous behavioral metrics during transcranial electrical stimulation (tES). Data include within participant application of nine High-Definition tES (HD-tES) types, targeting three cortical regions (frontal, motor, parietal) with three stimulation waveforms (DC, 5 Hz, 30 Hz); more than 783 total stimulation trials over 62 sessions with EEG, physiological (ECG, EOG), and continuous behavioral vigilance/alertness metrics. Experiment 1 and 2 consisted of participants performing a continuous vigilance/alertness task over three 70-minute and two 70.5-minute sessions, respectively. Demographic data were collected, as well as self-reported wellness questionnaires before and after each …