Digital Commons Network^™

Results Of A Phase 1, Randomized, Placebocontrolled First-In-Human Trial Of Griffithsin Formulated In A Carrageenan Vaginal Gel, Natalia Teleshova, Maria J. Keller, José A. Fernández Romero, Barbara A. Friedland, George W. Creasy, Marlena G. Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U. Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R. O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N. Fichorova, Tamara Kalir, Thomas M. Zydowsky

Publications and Research

HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT’s preclinical safety, lack of systemic absorption after vaginal administration in animal studies, and lack of cross-resistance with existing ARV drugs prompted its development for topical HIV PrEP. We investigated safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of PC-6500 (0.1% GRFT in a carrageenan (CG) gel) in healthy women after vaginal administration. This randomized, placebo-controlled, parallel group, double-blind first-in-human phase 1 study enrolled healthy, HIV-negative, non-pregnant women aged 24–45 years. In the open label period, all participants (n …

Me2b Alliance Validation Testing Report: Consumer Perception Of Legal Policies In Digital Technology, Noreen Y. Whysel, Karina Alexanyan, Shaun Spaulting, Julia Little

Publications and Research

Our relationship with technology involves legal agreements that we either review or enter into when using a technology, namely privacy policies and terms of service or terms of use (“TOS/TOU”). We initiated this research to understand if providing a formal rating of the legal policies (privacy policies and TOS/TOUs) would be valuable to consumers (or Me-s). From our early qualitative discussions, we noticed that people were unclear on whether these policies were legally binding contracts or not. Thus, a secondary objective emerged to quantitatively explore whether people knew who these policies protected (if anyone), and if the policies were perceived …

Hematologic Involvement As A Predictor Of Mortality In Covid-19 Patients In A Safety Net Hospital, Luis F. Gonzalez-Mosquera, Sandra Gomez-Paz, Eric Lam, Diana Cardenas-Maldonado, Joshua Fogel, Vishnu Adi, Sofia Rubinstein

Publications and Research

Introduction: COVID-19 affects the hematologic system. This article evaluated the impact of hematologic involvement of different blood cell line parameters of white blood cells including absolute neutrophil count (ANC), hemoglobin, and platelets in COVID-19 patients and their association with hospital mortality and length of stay (LOS).

Methods: This was a retrospective study of 475 patients with con- firmed positive COVID-19 infection and hematologic abnormalities in the metropolitan New York City area.

Results: Elevated absolute neutrophil count (OR: 1.20; 95% CI: 1.02-1.42; p < 0.05) increased days of hematologic involvement (OR: 4.44; 95% CI: 1.42-13.90; p < 0.05), and persistence of hematologic involvement at discharge (OR: 2.87; 95% CI: 1.20-6.90; p < 0.05) was associated with higher mortality. Higher hemoglobin at admission (OR: 0.77; 95% CI:0.60-0.98; p < 0.001) and platelets peak (OR: 0.995; 95% CI: 0.992-0.997; p < 0.001) were associated with decreased mor- tality. Patients with higher white blood cell peak (B = 0.46; SE = 0.07; p < 0.001) and higher hemoglobin at admission (B = 0.05; SE = 0.01; p < 0.001) were associated with higher LOS. Those with higher hemo- globin nadir (B = -0.06; SE = 0.01; p < 0.001), higher platelets nadir (B = -0.001; SE = < 0.001; p < 0.001), and hematologic involvement at discharge or death (B = -0.06; SE = 0.03; p < 0.05) were associated with lower LOS.

Conclusions: These findings can be used by clinicians to better risk- stratify patients with hematologic involvement in COVID-19 …

A Call For The Library Community To Deploy Best Practices Toward A Database For Biocultural Knowledge Relating To Climate Change, Martha B. Lerski

Publications and Research

Abstract

Purpose – In this paper, a call to the library and information science community to support documentation and conservation of cultural and biocultural heritage has been presented.

Design/methodology/approach – Based in existing Literature, this proposal is generative and descriptive— rather than prescriptive—regarding precisely how libraries should collaborate to employ technical and ethical best practices to provide access to vital data, research and cultural narratives relating to climate.

Findings – COVID-19 and climate destruction signal urgent global challenges. Library best practices are positioned to respond to climate change. Literature indicates how libraries preserve, share and cross-link cultural and scientific knowledge. …

Evolution Of Microscopic Heterogeneity And Dynamics In Choline Chloride-Based Deep Eutectic Solvents, Stephanie Spittle, Derrick Poe, Brain Doherty, Charles Kolodziej, Luke Heroux, Md Ashraful Haque, Henry Squire, Tyler Cosby, Yong Zhang, Carla Fraenza, Sahana Bhattacharyya, Madhusudan Tyagi, Jing Peng, Ramez A. Elgammal, Thomas Zawodzinski, Mark Tuckerman, Steve Greenbaum, Burcu Gurkan, Clemens Burda, Mark Dadmun, Edward J. Maginn, Joshua Sangoro

Publications and Research

Deep eutectic solvents (DESs) are an emerging class of non-aqueous solvents that are potentially scalable, easy to prepare and functionalize for many applications ranging from biomass processing to energy storage technologies. Predictive understanding of the fundamental correlations between local structure and macroscopic properties is needed to exploit the large design space and tunability of DESs for specific applications. Here, we employ a range of computational and experimental techniques that span length-scales from molecular to macroscopic and timescales from picoseconds to seconds to study the evolution of structure and dynamics in model DESs, namely Glyceline and Ethaline, starting from the parent …

The Rise And Fall Of Dopamine: A Two-Stage Model Of The Development And Entrenchment Of Anorexia Nervosa, Jeff A. Beeler, Nesha S. Burghardt

Publications and Research

Dopamine has long been implicated as a critical neural substrate mediating anorexia nervosa (AN). Despite nearly 50 years of research, the putative direction of change in dopamine function remains unclear and no consensus on the mechanistic role of dopamine in AN has been achieved. We hypothesize two stages i n AN– corresponding to initial development and entrenchment– characterized by opposite changes in dopamine. First, caloric restriction, particularly when combined with exercise, triggers an escalating spiral of increasing dopamine that facilitates the behavioral plasticity necessary to establish and reinforce weight-loss behaviors. Second, chronic self-starvation reverses this escalation to reduce or impair …

The Effect Of The Seattle Police-Free Chop Zone On Crime: A Microsynthetic Control Evaluation, Eric L. Piza, Nathan T. Connealy

Publications and Research

Research Summary:

Nightly confrontations occurred between protestors and officers outside of the Seattle Police Department’s (SPD’s) East precinct in the aftermath of George Floyd’s murder. On June 8, 2020, the SPD abandoned the East precinct in an attempt to calm the situation. Following closure of the precinct, the Capitol Hill Occupation Protest (CHOP) took hold in the surrounding 6-block area. The CHOP occupation lasted until July 1, 2020. Over this time period, CHOP operated as an autonomous zone, with police officers not patrolling and generally not responding to calls for police service within the area. We used the microsynthetic control …

Transcranial Direct Current Stimulation On Parkinson’S Disease: Systematic Review And Meta-Analysis, Paloma Cristina Alves De Oliveira, Thiago Anderson Brito De Araújo, Daniel Gomes Da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya

Publications and Research

Background: Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson’s disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD.

Objective: Investigate isolated tDCS effect in different brain areas and number of stimulated targets on PD motor symptoms.

Methods: A systematic review was carried out up to February 2021, in databases: Cochrane Library, EMBASE, PubMed/MEDLINE, Scopus, and Web of science. Full text articles evaluating effect of active tDCS (anodic or cathodic) vs. sham or control on motor symptoms of PD were …

Zines And Acquisitions: Adventure And Conundrum, Lauren E. Devoe

Publications and Research

Chapter 7 in the book "Zines in Libraries: Selecting, Purchasing, and Processing." This chapter focuses on workflows for the acquisitions of zines in libraries.

Their homegrown and esoteric aesthetic make zines important cultural and historical objects. Including them in library collections is a perfect way to amplify underrepresented voices. But the road from acquisition to cataloging these underground, self-published, and often fragile items can be difficult. This resource smooths the path forward, offering top-to-bottom guidance for collection development and acquisitions staff, administrators, catalogers, and access services librarians in understanding and processing zines for library collections.

Glycocalyx Mechanotransduction Mechanisms Are Involved In Renal Cancer Metastasis, Heriberto Moran, Limary M. Cancel, Peigen Huang, Sylvie Roberge, Tuoye Xu, John M. Tarbell, Lance L. Munn

Publications and Research

Mammalian cells, including cancer cells, are covered by a surface layer containing cell bound proteoglycans, glycoproteins, associated glycosaminoglycans and bound proteins that is commonly referred to as the glycocalyx. Solid tumors also have a dynamic fluid microenvironment with elevated interstitial flow. In the present work we further investigate the hypothesis that interstitial flow is sensed by the tumor glycocalyx leading to activation of cell motility and metastasis. Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme …

Covid-19 Challenges And Firm Responses: Analysis Of A City-Wide Census In A Developing Country, Bryan S. Weber, Toan Luu Duc Huynh

Publications and Research

We use the unique data set of 16,300 firms' responses for the large‐scale census survey in an urban area at Ho Chi Minh City (Vietnam) to study how firms perceived their problems and responded to during the COVID‐19 pandemic. We provide estimates of 65 cross‐associations between a firm's challenges during the pandemic and their responses. We find several firm characteristics that suggest increased likelihood of pandemic response, including some, such as state ownership, which are typically associated with being slow to respond to market conditions. A theoretical model is posited that matches with the rapidly declared survey response.

Thrombospondin-1 Expression And Modulation Of Wnt And Hippo Signaling Pathways During The Early Phase Of Trypanosoma Cruzi Infection Of Heart Endothelial Cells, Ashutosh Arun, Kayla J. Rayford, Ayorinde Cooley, Tanu Rana, Girish Rachakonda, Fernando Villalta, Siddharth Pratap, Maria F. Lima, Nader Sheibani, Pius N. Nde

Publications and Research

The protozoan parasite, Trypanosoma cruzi, causes severe morbidity and mortality in afflicted individuals. Approximately 30% of T. cruzi infected individuals present with cardiac pathology. The invasive forms of the parasite are carried in the vascular system to infect other cells of the body. During transportation, the molecular mechanisms by which the parasite signals and interact with host endothelial cells (EC) especially heart endothelium is currently unknown. The parasite increases host thrombospondin-1 (TSP1) expression and activates the Wnt/β-catenin and hippo signaling pathways during the early phase of infection. The links between TSP1 and activation of the signaling pathways and …

Toward A Multimodal Computer-Aided Diagnostic Tool For Alzheimer’S Disease Conversion, Danilo Pena, Jessika Suescun, Mya Schiess, Timothy M. Ellmore, Luca Giancardo, Alzheimer’S Disease Neuroimaging Initiative

Publications and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. It is one of the leading sources of morbidity and mortality in the aging population AD cardinal symptoms include memory and executive function impairment that profoundly alters a patient’s ability to perform activities of daily living. People with mild cognitive impairment (MCI) exhibit many of the early clinical symptoms of patients with AD and have a high chance of converting to AD in their lifetime. Diagnostic criteria rely on clinical assessment and brain magnetic resonance imaging (MRI). Many groups are working to help automate this process to improve the clinical workflow. Current …

Who’S Afraid Of Bob Jones?: 'Fundamental National Public Policy' And Critical Race Theory In A Delicate Democracy, Lynn D. Lu

Publications and Research

In Summer of 2021, Republican legislators across the United States introduced a host of bills to prohibit government funding for schools or agencies that teach critical race theory (“CRT”), described by the American Association of Law Schools not as a single doctrine but a set of “frameworks” to “explain and illustrate how structural racism produces racial inequity within our social, economic, political, legal, and educational systems[,] even absent individual racist intent.” Characterizing such an explicitly race-conscious analysis of legal and social institutions as “divisive,” opponents of CRT, such as former Vice President Mike Pence, labeled it “nothing short of state-sponsored …

Stratified Entry Into Illegality: How Immigration Policy Shapes Being Undocumented, Sofya Aptekar, Amy Hsin

Publications and Research

Research shows that legal status is a critical axis of stratification in the United States but is less clear about the variably permeable boundaries around illegality and the systematic ways in which migrants are channeled into and out of the liminal states of illegality. Drawing on analysis of 105 interviews with a diverse group of undocumented or formerly undocumented immigrant young adults in New York City collected in 2018-19, we introduce the concept of stratified entry into illegality to illustrate how migrants’ nationality, race, and socioeconomic status shape their mode of entry which, in turn, shapes opportunities to adjust legal …

El Laboratorio Cinegráfico De Pedro Pietri, Rojo Robles Mejias

Publications and Research

En su relato “Lost in the Museum of Natural History” Pedro Pietri se inserta en la narración como personaje y como fuente de historias inspiradas en la violencia de los géneros del western, los biker films y los melodramas. Esta aproximación a la experimentación literaria, la alteración sensorial y fílmica escenifica una crisis en la enunciación y la representación que hecha luces sobre las relaciones entre las desigualdades sociales, la violencia y la subjetividad.

Family Participatory Research Practices: A Reflection, Serena Troiani

Publications and Research

This column discusses the importance of family participatory research practices with particular regard for vulnerable populations and alternative learning opportunities and the need for an expanded approach to the use of multimodalities in the classroom. The author reflects upon her experience as she conducted her dissertation, a case study with her nephew, an adolescent diagnosed with autism, exploring his use of multimodalities as an expressive practice, and to see how they informed his meaning making. The column addresses the author’s various roles and positionality and how the author’s use of a reflexive journal provided a space to document any ethical …

A Study Protocol To Prepare An Rbd Protein For Vaccine Against Covid-19, Z.M.G. Sarwar Jahangir, Arleta Helena Marnik

Publications and Research

Background: SARS-CoV-2 pandemic is a global threat to humans and the world’s economy. Effective and safe vaccines against this virus are essential to control and eradicate the pandemic. The currently applied vaccines carry SARS-CoV-2 spike-protein mRNA/cDNA. These vaccines go through several cellular processes in the recipients for producing antigens. On the contrary, the SARS-CoV-2 RBD (receptor binding domain)-protein is an antigen. It will directly stimulate antibody production against SARS-CoV-2. Hence, we propose to produce SARS-CoV-2 RBD-protein as a fast acting, effective and safe vaccine.

Methods: We propose to reconstruct a plasmid carrying three types of DNA sequences: RBD cDNA, FP …

The Changing Realities Of Open-Access Reading: Where Are We Now? Where Might We Go Next?, Cheryl Hogue Smith, Joanne Baird Giordano

Publications and Research

I wrote this introduction to the special issue on reading. Guest editors Giordano and Smith open the discussion about reading as an issue of equity.

Mike Rose's Two-Year College Advocacy, Cheryl Hogue Smith, Darin Jensen

Publications and Research

Through our dialogue in this article, we reflect upon Mike Rose's personal influence on us as literacy workers and on two-year college English studies.

The Imaginal Lexicon Of Aging Studies, William Ebenstein

Publications and Research

Aging Studies focuses on the cultural, humanistic and experiential aspects of aging insofar as these are already embedded in literature, art, language and everyday life. The lexicon of this multi-disciplinary field has evolved in response to shifts in cultural attitudes, social roles, and conceptual frameworks. At the same time, many age-related words have links to poetic imagery and ancient myths, and to evocative etymologies that conjure an historical context. The article looks at the ongoing and surprisingly difficult effort to find the right word to call an older person. It reviews the language and literary genres associated with longevity. And, …

What Faith Teaches Us: An Essay On Faith Adiele, Rochelle Spencer

Publications and Research

Essay on the writer Faith Adiele and women's bodies.

Feeding Memories: A Conversation With Writers Who Write About Food, Rochelle Spencer, Tara Christina, Dera R. Williams, Shannon Holbrook

Publications and Research

Rochelle Spencer interviews Tara Christina, a writer and educator with degrees in holistic nutrition and is the founder and CEO of Tara’s Teas, an artisanal line of organic, loose leaf tea blends; Dera R. Williams whose work appears in several anthologies and you can find her food-related writing on her blog; and Shannon Holbrook, a writer and wine and food consultant who has organized prominent food-writing events throughout the Bay Area.

The Blind Spots Of Sociotechnical Imaginaries: Covid-19 Scepticism In Brazil, The United Kingdom And The United States, Renan Gonçalves Leonel Da Silva, Larry Au

Publications and Research

During the first wave of the coronavirus pandemic in 2020, experts and policymakers mobilised various slogans to compel the public to help defeat COVID-19. By comparing Brazil, the United Kingdom and the United States, this study shows how dominant sociotechnical imaginaries tied to the slogans were mobilised. We argue that the blind spots of these dominant sociotechnical imaginaries contributed to subversive sociotechnical imaginaries and made room for COVID-19 scepticism. In Brazil, calls to ‘take care of yourself’ contributed to a sceptical stance that individualised responsibility. In the United Kingdom, calls to ‘protect the NHS’ contributed to sceptical accusations of whataboutism …

Biomedical Applications Of Lanthanide Nanomaterials, For Imaging, Sensing And Therapy, Qize Zhang, Stephen O'Brien, Jan Grimm

Publications and Research

The application of nanomaterials made of rare earth elements within biomedical sciences continues to make significant progress. The rare earth elements, also called the lanthanides, play an essential role in modern life through materials and electronics. As we learn more about their utility, function, and underlying physics, we can contemplate extending their applications to biomedicine. This particularly applies to diagnosis and radiation therapy due to their relatively unique features, such as an ultra-wide Stokes shift in the luminescence, variable magnetism and potentially tunable properties, due to the library of lanthanides available and their multivalent oxidation state chemistry. The ability to …

Understanding Covid-19 Among People Of Dominican Descent In The U.S.: A Comparison Of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island And Connecticut, Ramona Hernandez, Pedro Ortega, Nancy Sohler, Sarah Marrara

Publications and Research

The present study “Understanding COVID-19 Among People of Dominican Descent in the U.S.: A Comparison of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island and Connecticut” is the first research study to examine the experience of people of Dominican origins residing in the United States (U.S.) amidst the pandemic caused by the SARS-CoV-2 virus. The current study is based on a probabilistic and representative sample of Dominicans across the seven states in which the majority—85%—of Dominicans living in the U.S. reside. The Dominican Studies Institute (CUNY-DSI) at City College and the School of Medicine, both of the City University …

The Urban Maroons Of Afro-Dominican Music, Paul Austerlitz

Publications and Research

No abstract provided.

Supportive Strategies For Community College Human Services Online Internships: A Case Study Of Guttman Community College’S Remote Binary Model, Anya Y. Spector, Nicole Kras

Publications and Research

Creating a viable human services internship program at the community college level presents many challenges, from retaining partner agencies willing to supervise, often inexperienced, beginning students, to retaining students willing to overcome personal, academic, and financial challenges to participate in an internship. These challenges were exacerbated by restrictions placed on in-person teaching and internships during the COVID-19 pandemic. In response, Guttman Community College’s human services program has developed a remote binary internship model that offers fieldwork students the benefits of participating in an internship through online agency-based supervised field placements or class-based asynchronous assignments for fieldwork students that cannot participate …

Sex Is As Sex Does: Governing Transgender Identity (Preface And Introduction), Paisley Currah

Publications and Research

No abstract provided.

The Politics Of Recognition In Building Pluriversal Possibilities: Posthumanism, Buen Vivir, And Zapatismo, Robert Leston

Publications and Research

No abstract provided.