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A Canadian Study Of Cisplatin Metabolomics And Nephrotoxicity (Accent): A Clinical Research Protocol, Anshika Jain, Ryan Huang, Jasmine Lee, Natasha Jawa, Yong Jin Lim, Mike Guron, Sharon Abish, Paul C. Boutros, Michael Brudno, Bruce Carleton, Geoffrey D.E. Cuvelier, Lakshman Gunaratnam, Cheryl Ho, Khosrow Adeli, Sara Kuruvilla, Giles Lajoie, Geoffrey Liu, Paul C. Nathan, Shahrad Rod Rassekh, Michael Rieder, Sushrut S. Waikar, Stephen A. Welch, Matthew A. Weir, Eric Winquist, David S. Wishart, Alexandra P. Zorzi
A Canadian Study Of Cisplatin Metabolomics And Nephrotoxicity (Accent): A Clinical Research Protocol, Anshika Jain, Ryan Huang, Jasmine Lee, Natasha Jawa, Yong Jin Lim, Mike Guron, Sharon Abish, Paul C. Boutros, Michael Brudno, Bruce Carleton, Geoffrey D.E. Cuvelier, Lakshman Gunaratnam, Cheryl Ho, Khosrow Adeli, Sara Kuruvilla, Giles Lajoie, Geoffrey Liu, Paul C. Nathan, Shahrad Rod Rassekh, Michael Rieder, Sushrut S. Waikar, Stephen A. Welch, Matthew A. Weir, Eric Winquist, David S. Wishart, Alexandra P. Zorzi
Paediatrics Publications
Background: Cisplatin, a chemotherapy used to treat solid tumors, causes acute kidney injury (AKI), a known risk factor for chronic kidney disease and mortality. AKI diagnosis relies on biomarkers which are only measurable after kidney damage has occurred and functional impairment is apparent; this prevents timely AKI diagnosis and treatment. Metabolomics seeks to identify metabolite patterns involved in cell tissue metabolism related to disease or patient factors. The A Canadian study of Cisplatin mEtabolomics and NephroToxicity (ACCENT) team was established to harness the power of metabolomics to identify novel biomarkers that predict risk and discriminate for presence of cisplatin nephrotoxicity, …
Pediatric Life Support: 2020 International Consensus On Cardiopulmonary Resuscitation And Emergency Cardiovascular Care Science With Treatment Recommendations, Ian K. Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L. Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne Marie Guerguerian, Vinay M. Nadkarni, Kee Chong Ng, Gabrielle A. Nuthall, Gene Y.K. Ong, Amelia G. Reis, Stephen M. Schexnayder, Barnaby R. Scholefield, Janice A. Tijssen, Jerry P. Nolan, Peter T. Morley, Patrick Van De Voorde, Arno L. Zaritsky, Allan R. De Caen, Alex Moylan, Alexis Topjian, Kevin Nation, Shinchiro Ohshimo, Ronald A. Bronicki, Kelly D. Kadlec
Pediatric Life Support: 2020 International Consensus On Cardiopulmonary Resuscitation And Emergency Cardiovascular Care Science With Treatment Recommendations, Ian K. Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L. Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne Marie Guerguerian, Vinay M. Nadkarni, Kee Chong Ng, Gabrielle A. Nuthall, Gene Y.K. Ong, Amelia G. Reis, Stephen M. Schexnayder, Barnaby R. Scholefield, Janice A. Tijssen, Jerry P. Nolan, Peter T. Morley, Patrick Van De Voorde, Arno L. Zaritsky, Allan R. De Caen, Alex Moylan, Alexis Topjian, Kevin Nation, Shinchiro Ohshimo, Ronald A. Bronicki, Kelly D. Kadlec
Paediatrics Publications
This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping reviews, and evidence updates. Per agreement with the evidence evaluation recommendations of the International Liaison Committee on Resuscitation, only systematic reviews could result in a new or revised treatment recommendation. Systematic reviews performed for this 2020 CoSTR for pediatric life support included the topics of sequencing of airway-breaths-compressions versus compressions-airway-breaths …
Pediatric Life Support: 2020 International Consensus On Cardiopulmonary Resuscitation And Emergency Cardiovascular Care Science With Treatment Recommendations, Ian K. Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L. Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne Marie Guerguerian, Vinay M. Nadkarni, Kee Chong Ng, Gabrielle A. Nuthall, Gene Y.K. Ong, Amelia G. Reis, Stephen M. Schexnayder, Barnaby R. Scholefield, Janice A. Tijssen, Jerry P. Nolan, Peter T. Morley, Patrick Van De Voorde, Arno L. Zaritsky, Allan R. De Caen
Pediatric Life Support: 2020 International Consensus On Cardiopulmonary Resuscitation And Emergency Cardiovascular Care Science With Treatment Recommendations, Ian K. Maconochie, Richard Aickin, Mary Fran Hazinski, Dianne L. Atkins, Robert Bingham, Thomaz Bittencourt Couto, Anne Marie Guerguerian, Vinay M. Nadkarni, Kee Chong Ng, Gabrielle A. Nuthall, Gene Y.K. Ong, Amelia G. Reis, Stephen M. Schexnayder, Barnaby R. Scholefield, Janice A. Tijssen, Jerry P. Nolan, Peter T. Morley, Patrick Van De Voorde, Arno L. Zaritsky, Allan R. De Caen
Paediatrics Publications
This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping reviews, and evidence updates. Per agreement with the evidence evaluation recommendations of the International Liaison Committee on Resuscitation, only systematic reviews could result in a new or revised treatment recommendation. Systematic reviews performed for this 2020 CoSTR for pediatric life support included the topics of sequencing of airway-breaths-compressions versus compressions-airway-breaths …
Standards Of Care For Children In Emergency Departments: Executive Summary., Rodrick K Lim, Baljit Cheema, Catherine Cartman, Ffion Davies, Marianne Gausche-Hill, Felix Hay
Standards Of Care For Children In Emergency Departments: Executive Summary., Rodrick K Lim, Baljit Cheema, Catherine Cartman, Ffion Davies, Marianne Gausche-Hill, Felix Hay
Paediatrics Publications
No abstract provided.
Use Of A Radial Artery ‘Slender’ Sheath For Facilitating Transfemoral Arterial Access For Neuroendovascular Embolization In A Very Young Infant, Timothy L. Miao, Enriqueta Lucar Figueroa, Khalid Bajunaid, Michael Mayich, Sandrine De Ribaupierre, Sachin K. Pandey
Use Of A Radial Artery ‘Slender’ Sheath For Facilitating Transfemoral Arterial Access For Neuroendovascular Embolization In A Very Young Infant, Timothy L. Miao, Enriqueta Lucar Figueroa, Khalid Bajunaid, Michael Mayich, Sandrine De Ribaupierre, Sachin K. Pandey
Paediatrics Publications
Pediatric neuroendovascular procedures are increasingly performed as several studies have shown the safety of these interventions. In the literature, an upper limit of 4 French catheter size is conventionally used for femoral access in neuroangiography of very young infants. However, this constraint in luminal size may not allow for more complex procedures. We present the previously unreported use of a radial 5 French slender catheter with ultrathin walls for femoral access for aneurysm embolization in a 3-month-old boy presenting with left M2 aneurysm rupture.
Evaluation Of Primary Caregivers' Perceptions On Home Trampoline Use, Supriya Singh, Kamary Coriolano, Jacob Davidson, Megan Cashin, Timothy Carey, Debra Bartley
Evaluation Of Primary Caregivers' Perceptions On Home Trampoline Use, Supriya Singh, Kamary Coriolano, Jacob Davidson, Megan Cashin, Timothy Carey, Debra Bartley
Paediatrics Publications
Trampolines are widely used by children, but trampoline injuries can be severe and may require hospital care or even surgery. This pilot study examined the effectiveness of an educational intervention on caregivers' perceptions of trampoline use and safety for their children. Primary caregivers were recruited from the orthopedic clinic at the Children's Hospital at our institution in 2015. Caregivers were asked to complete a survey at two time points, initially in clinic and one week post educational intervention. The educational intervention was a pamphlet outlining trampoline safety data. Data analysis occurred in 2016. From the 100 primary caregivers recruited, 39 …
Eculizumab Dosing In Infants, M Kobrzynski, B Wile, S S Huang, G Filler
Eculizumab Dosing In Infants, M Kobrzynski, B Wile, S S Huang, G Filler
Paediatrics Publications
Eculizumab is the therapy of choice for patients with atypical hemolytic uremic syndrome (aHUS). Dosing recommendations stem from two trials: one retrospective trial (19 children and 5 infants) and one prospective trial (22 patients and 5 infants). This case report highlights the need for more precise dosing recommendations in children, particularly in infants, and for smaller vials of the medication to facilitate more precise dosing. Such changes would ensure that adverse events are minimized and that the children with aHUS who are treated with eculizumab experience an optimal clinical response.
When Crrt On Ecmo Is Not Enough For Potassium Clearance: A Case Report, Janice A. Tijssen, Guido Filler
When Crrt On Ecmo Is Not Enough For Potassium Clearance: A Case Report, Janice A. Tijssen, Guido Filler
Paediatrics Publications
Background: Continuous renal replacement therapy (CRRT) is an excellent method used to remove fluid and solutes. It may also reduce the systemic inflammatory response for patients on extracorporeal membrane oxygenation (ECMO) support. Theobjective of this report is to describe a case where CRRT in combination with ECMO was insufficient to control hyperkalemia. Methods: We report the case of an adolescent patient with refractory symptomatic hyperkalemia due to substantial rhabdomyolysis in which CRRT insufficiently cleared the patient's excess potassium. Results: Intermittent hemodialysis (IHD) was added and proved successful. The patient was weaned off ECMO, CRRT, and IHD, and his cardiac and …
Is It Time To Stop Teaching Bystanders Ventilation As Part Of Pediatric Cardiopulmonary Resuscitation?, Allan De Caen, Janice A. Tijssen
Is It Time To Stop Teaching Bystanders Ventilation As Part Of Pediatric Cardiopulmonary Resuscitation?, Allan De Caen, Janice A. Tijssen
Paediatrics Publications
No abstract provided.
Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update For Cardiopulmonary Resuscitation And Emergency Cardiovascular Care, Allan R. De Caen, Marc D. Berg, Leon Chameides, Cheryl K. Gooden, Robert W. Hickey, Halden F. Scott, Robert M. Sutton, Janice A. Tijssen, Alexis Topjian, Élise W. Van Der Jagt, Stephen M. Schexnayder, Ricardo A. Samson
Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update For Cardiopulmonary Resuscitation And Emergency Cardiovascular Care, Allan R. De Caen, Marc D. Berg, Leon Chameides, Cheryl K. Gooden, Robert W. Hickey, Halden F. Scott, Robert M. Sutton, Janice A. Tijssen, Alexis Topjian, Élise W. Van Der Jagt, Stephen M. Schexnayder, Ricardo A. Samson
Paediatrics Publications
No abstract provided.
Using Simplified Blood Pressure Tables To Avoid Underdiagnosing Childhood Hypertension, Ajay P. Sharma, Javed Mohammed, Benson Thomas, Ram N. Singh, Guido Filler
Using Simplified Blood Pressure Tables To Avoid Underdiagnosing Childhood Hypertension, Ajay P. Sharma, Javed Mohammed, Benson Thomas, Ram N. Singh, Guido Filler
Paediatrics Publications
Background: Recent studies have revealed that hypertension remains underdiagnosed in a significant number of children despite their recorded office blood pressure (OBP) exceeding the recommended fourth report OBP thresholds. Simplified OBP thresholds have been proposed to reduce this underdiagnosis of hypertension in children. In clinical practice, OBP screened as elevated according to the fourth report OBP thresholds are referred for ambulatory blood pressure (ABP) monitoring to rule out 'white coat' hypertension. Objectives: The present study tested the usefulness of simplified OBP thresholds to screen abnormal OBP for ABP monitoring referral. Methods: A total of 155 subjects were retrospectively analyzed with …
Health-Related Quality Of Life In Children With Duchennemuscular Dystrophy: A Review, Yi Wei, Kathy Speechley, Craig Campbell
Health-Related Quality Of Life In Children With Duchennemuscular Dystrophy: A Review, Yi Wei, Kathy Speechley, Craig Campbell
Paediatrics Publications
In pediatric chronic illness, improving health-related quality of life (HRQOL) has become one of the most important goals of disease management. Duchenne muscular dystrophy (DMD) is a debilitating, progressive and chronic neuromuscular disorder affecting boys. The purpose of this review is to provide an overview of published research on HRQOL in the pediatric DMD population, describe the instruments used and summarize the study findings. The databases searched were Medline, Embase and PsycInfo. The literature search yielded 167 articles, of which 19 were included in this review. The studies were published between 2005 and 2013 across nine countries. Thirteen different generic …
Postresuscitation Debriefing In The Pediatric Emergency Department: A National Needs Assessment, Naminder Sandhu, Walter Eppich, Angelo Mikrogianakis, Vincent Grant, Traci Robinson, Adam Cheng, Rod Lim, Allan Shefrin
Postresuscitation Debriefing In The Pediatric Emergency Department: A National Needs Assessment, Naminder Sandhu, Walter Eppich, Angelo Mikrogianakis, Vincent Grant, Traci Robinson, Adam Cheng, Rod Lim, Allan Shefrin
Paediatrics Publications
Results: Data were analyzed from 183 participants (48.7% response rate). Although 88.8% of the participants believed that debriefing is an important process, 52.5% indicated that debriefing after real resuscitations occurs less than 25% of the time and 68.3% indicated that no expectation exists for PRD at their institution. Although 83.7% of participants believed that facilitators should have a specific skill set developed through formal training sessions, 63.4% had no previous training in debriefing. Seventy-two percent felt that medical and crisis resource management issues are dealt with adequately when PRD occurs, and 90.4% indicated that ED workload and time shortages are …
Ontario Children Have Outgrown The Broselow Tape, William Ken Milne, Abeer Yasin, Janine Knight, Daniel Noel, Richard Lubell, Guido Filler
Ontario Children Have Outgrown The Broselow Tape, William Ken Milne, Abeer Yasin, Janine Knight, Daniel Noel, Richard Lubell, Guido Filler
Paediatrics Publications
Objective: The Broselow Pediatric Emergency Tape (Armstrong Medical Industries, Inc., Lincolnshire, IL) (BT) is a well-established length-based tool for estimation of body weight for children during resuscitation. In view of pandemic childhood obesity, the BT may no longer accurately estimate weight. We therefore studied the BT in children from Ontario in a large recent patient cohort. Methods: Actual height and weight were obtained from an urban and a rural setting. Children were prospectively recruited between April 2007 and July 2008 from the emergency department and outpatient clinics at the London Health Science Centre. Rural children from junior kindergarten to grade …
Variations In The Management Of Pneumonia In Pediatric Emergency Departments: Compliance With The Guidelines, Aiman Alak, Jamie A. Seabrook, Michael J. Rieder
Variations In The Management Of Pneumonia In Pediatric Emergency Departments: Compliance With The Guidelines, Aiman Alak, Jamie A. Seabrook, Michael J. Rieder
Paediatrics Publications
Objective: We sought to assess compliance with evidence-based guidelines for the management of pediatric pneumonia, including the variations in tests ordered and antimicrobials prescribed. Our primary hypothesis was that compliance with the treatment recommendations from the most current guidelines would be low for antimicrobial prescriptions. Methods: We conducted a chart review at the Children's Hospital in London, Ont., to assess variation in the management of pediatric pneumonia. All patients aged 3 months to 18 years seen at the pediatric emergency department between Apr. 1, 2006, and Mar. 31, 2007, with a diagnosis of pneumonia were eligible for inclusion in the …