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A Test For Common Genetic And Environmental Vulnerability To Depression And Diabetes, Jeffrey F. Scherrer, Hong Xian, Patrick J. Lustman, Carol E. Franz, Jeanne Mccaffery, Michael J. Lyons, Kristen C. Jacobsen, William S. Kremen Jan 2011

A Test For Common Genetic And Environmental Vulnerability To Depression And Diabetes, Jeffrey F. Scherrer, Hong Xian, Patrick J. Lustman, Carol E. Franz, Jeanne Mccaffery, Michael J. Lyons, Kristen C. Jacobsen, William S. Kremen

Open Access Publications

No abstract provided.


Eisosome Proteins Assemble Into A Membrane Scaffold, Lena Karotki, Juha T. Huiskonen, Christopher J. Stefan, Natasza E. Ziółkowska, Robyn Roth, Michal A. Surma, Nevan J. Krogan, Scott D. Emr, John Heuser, Kay Grünewald, Tobias C. Walther Jan 2011

Eisosome Proteins Assemble Into A Membrane Scaffold, Lena Karotki, Juha T. Huiskonen, Christopher J. Stefan, Natasza E. Ziółkowska, Robyn Roth, Michal A. Surma, Nevan J. Krogan, Scott D. Emr, John Heuser, Kay Grünewald, Tobias C. Walther

Open Access Publications

Spatial organization of membranes into domains of distinct protein and lipid composition is a fundamental feature of biological systems. The plasma membrane is organized in such domains to efficiently orchestrate the many reactions occurring there simultaneously. Despite the almost universal presence of membrane domains, mechanisms of their formation are often unclear. Yeast cells feature prominent plasma membrane domain organization, which is at least partially mediated by eisosomes. Eisosomes are large protein complexes that are primarily composed of many subunits of two Bin-Amphiphysin-Rvs domain-containing proteins, Pil1 and Lsp1. In this paper, we show that these proteins self-assemble into higher-order structures and …


A Genomic Storm In Critically Injured Humans, Wenzhong Xiao, Bernard H. Brownstein, Et Al Jan 2011

A Genomic Storm In Critically Injured Humans, Wenzhong Xiao, Bernard H. Brownstein, Et Al

Open Access Publications

No abstract provided.


Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 2: Descriptive And Inferential Statistical Methods, Methodius G. Tuuli, Anthony O. Odibo Jan 2011

Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 2: Descriptive And Inferential Statistical Methods, Methodius G. Tuuli, Anthony O. Odibo

Open Access Publications

No abstract provided.


Fig1 Facilitates Calcium Influx And Localizes To Membranes Destined To Undergo Fusion During Mating In Candida Albicans, Meng Yang, Alexandra Brand, Thyagarajan Srikantha, Karla J. Daniels, David R. Soll, Neil A.R. Gow Jan 2011

Fig1 Facilitates Calcium Influx And Localizes To Membranes Destined To Undergo Fusion During Mating In Candida Albicans, Meng Yang, Alexandra Brand, Thyagarajan Srikantha, Karla J. Daniels, David R. Soll, Neil A.R. Gow

Open Access Publications

No abstract provided.


Distinct Time-Resolved Roles For Two Catabolite-Sensing Pathways During Streptococcus Pyogenes Infection, Colin C. Kietzman, Michael G. Caparon Jan 2011

Distinct Time-Resolved Roles For Two Catabolite-Sensing Pathways During Streptococcus Pyogenes Infection, Colin C. Kietzman, Michael G. Caparon

Open Access Publications

No abstract provided.


Inhibition Of Indoleamine 2,3-Dioxygenase Activity By Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia Trachomatis Persistence In Human Epithelial Cells, Joyce A. Ibana, Robert J. Belland, Arnold H. Zea, Danny J. Schust, Takeshi Nagamatsu, Yasser M. Abdelrahman, David J. Tate, Wandy L. Beatty, Ashok A. Aiyar, Alison J. Quayle Jan 2011

Inhibition Of Indoleamine 2,3-Dioxygenase Activity By Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia Trachomatis Persistence In Human Epithelial Cells, Joyce A. Ibana, Robert J. Belland, Arnold H. Zea, Danny J. Schust, Takeshi Nagamatsu, Yasser M. Abdelrahman, David J. Tate, Wandy L. Beatty, Ashok A. Aiyar, Alison J. Quayle

Open Access Publications

No abstract provided.


Structural And Functional Interactions Between The Cholera Toxin A1 Subunit And Erdj3/Hedj, A Chaperone Of The Endoplasmic Reticulum, Shane Massey, Helen Burress, Michael Taylor, Kathleen N. Nemec, Supriyo Ray, David B. Haslam, Ken Teter Jan 2011

Structural And Functional Interactions Between The Cholera Toxin A1 Subunit And Erdj3/Hedj, A Chaperone Of The Endoplasmic Reticulum, Shane Massey, Helen Burress, Michael Taylor, Kathleen N. Nemec, Supriyo Ray, David B. Haslam, Ken Teter

Open Access Publications

No abstract provided.


Population Dynamics And Niche Distribution Of Uropathogenic Escherichia Coli During Acute And Chronic Urinary Tract Infection, Drew J. Schwartz, Swaine L. Chen, Scott J. Hultgren, Patrick C. Seed Jan 2011

Population Dynamics And Niche Distribution Of Uropathogenic Escherichia Coli During Acute And Chronic Urinary Tract Infection, Drew J. Schwartz, Swaine L. Chen, Scott J. Hultgren, Patrick C. Seed

Open Access Publications

No abstract provided.


Immune Activation And Suppression By Group B Streptococcus In A Murine Model Of Urinary Tract Infection, Kimberly A. Kline, Drew J. Schwartz, Warren G. Lewis, Scott J. Hultgren, Amanda L. Lewis Jan 2011

Immune Activation And Suppression By Group B Streptococcus In A Murine Model Of Urinary Tract Infection, Kimberly A. Kline, Drew J. Schwartz, Warren G. Lewis, Scott J. Hultgren, Amanda L. Lewis

Open Access Publications

No abstract provided.


Differential Microbicidal Effects Of Human Histone Proteins H2a And H2b On Leishmania Promastigotes And Amastigotes, Yingwei Wang, Yang Chen, Lijun Xin, Stephen M. Beverley, Eric D. Carlsen, Vsevolod Popov, Kwang-Poo Chang, Ming Wang, Lynn Soong Jan 2011

Differential Microbicidal Effects Of Human Histone Proteins H2a And H2b On Leishmania Promastigotes And Amastigotes, Yingwei Wang, Yang Chen, Lijun Xin, Stephen M. Beverley, Eric D. Carlsen, Vsevolod Popov, Kwang-Poo Chang, Ming Wang, Lynn Soong

Open Access Publications

No abstract provided.


Register Shifting Of An Insulin Peptide-Mhc Complex Allows Diabetogenic T Cells To Escape Thymic Deletion, James F. Mohan, Shirley J. Petzold, Emil R. Unanue Jan 2011

Register Shifting Of An Insulin Peptide-Mhc Complex Allows Diabetogenic T Cells To Escape Thymic Deletion, James F. Mohan, Shirley J. Petzold, Emil R. Unanue

Open Access Publications

In nonobese diabetic (NOD) mice, two sets of autoreactive CD4(+) T cells recognize the B:9-23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen-presenting cells (APCs). These T cells are highly deleted in the thymus. The second set, type B, does not recognize insulin protein but reacts with soluble B chain peptide. This set is not deleted in the thymus but is activated in the islets of Langerhans. In this study, we examine the specificity of these two types of T cells. The protein-reactive set recognizes the stretch of residues 13-21 of the insulin …


Innate And Cytokine-Driven Signals, Rather Than Microbial Antigens, Dominate In Natural Killer T Cell Activation During Microbial Infection, Manfred Brigl, Raju V.V. Tatituri, Gerald F.M. Watts, Veemal Bhowruth, Elizabeth A. Leadbetter, Nathaniel Barton, Nadia R. Cohen, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner Jan 2011

Innate And Cytokine-Driven Signals, Rather Than Microbial Antigens, Dominate In Natural Killer T Cell Activation During Microbial Infection, Manfred Brigl, Raju V.V. Tatituri, Gerald F.M. Watts, Veemal Bhowruth, Elizabeth A. Leadbetter, Nathaniel Barton, Nadia R. Cohen, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner

Open Access Publications

Invariant natural killer T cells (iNKT cells) are critical for host defense against a variety of microbial pathogens. However, the central question of how iNKT cells are activated by microbes has not been fully explained. The example of adaptive MHC-restricted T cells, studies using synthetic pharmacological α-galactosylceramides, and the recent discovery of microbial iNKT cell ligands have all suggested that recognition of foreign lipid antigens is the main driver for iNKT cell activation during infection. However, when we compared the role of microbial antigens versus innate cytokine-driven mechanisms, we found that iNKT cell interferon-γ production after in vitro stimulation or …


Photo Quiz: A 32-Year-Old Male With A 2-Month History Of Cough, Fatigue, And Weight Loss, Carey-Ann D. Burnham, W. Michael Dunne Jr. Jan 2011

Photo Quiz: A 32-Year-Old Male With A 2-Month History Of Cough, Fatigue, And Weight Loss, Carey-Ann D. Burnham, W. Michael Dunne Jr.

Open Access Publications

No abstract provided.


West Nile Virus Infection In Killer Whale, Texas, Usa, 2007, Judy St. Leger, Guang Wu, Mark Anderson, Les Dalton, Erika Nilson, David Wang Jan 2011

West Nile Virus Infection In Killer Whale, Texas, Usa, 2007, Judy St. Leger, Guang Wu, Mark Anderson, Les Dalton, Erika Nilson, David Wang

Open Access Publications

No abstract provided.


Cxcr7 Antagonism Prevents Axonal Injury During Experimental Autoimmune Encephalomyelitis As Revealed By In Vivo Axial Diffusivity, Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S. Klein Jan 2011

Cxcr7 Antagonism Prevents Axonal Injury During Experimental Autoimmune Encephalomyelitis As Revealed By In Vivo Axial Diffusivity, Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S. Klein

Open Access Publications

No abstract provided.


Pregnancy In Multiple System Atrophy: A Case Report, Lirong Zhu, Nigel J. Cairns, Samer D. Tabbal, Brad A. Racette Jan 2011

Pregnancy In Multiple System Atrophy: A Case Report, Lirong Zhu, Nigel J. Cairns, Samer D. Tabbal, Brad A. Racette

Open Access Publications

No abstract provided.


Engraftment Of Insulin-Producing Cells From Porcine Islets In Non-Immune-Suppressed Rats Or Nonhuman Primates Transplanted Previously With Embryonic Pig Pancreas, Marc R. Hammerman Jan 2011

Engraftment Of Insulin-Producing Cells From Porcine Islets In Non-Immune-Suppressed Rats Or Nonhuman Primates Transplanted Previously With Embryonic Pig Pancreas, Marc R. Hammerman

Open Access Publications

No abstract provided.


Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 1: Evaluating The Efficiency Of Screening And Diagnostic Tests, Katherine R. Goetzinger, Anthony O. Odibo Jan 2011

Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 1: Evaluating The Efficiency Of Screening And Diagnostic Tests, Katherine R. Goetzinger, Anthony O. Odibo

Open Access Publications

No abstract provided.


The Genetic Association Between Personality And Major Depression Or Bipolar Disorder. A Polygenic Score Analysis Using Genome-Wide Association Data, P. A. F. Madden, A. C. Heath, M. L. Pergadia, A. Agrawal, P. Lin, R. A. Grucza, L. J. Bierut, Et Al Jan 2011

The Genetic Association Between Personality And Major Depression Or Bipolar Disorder. A Polygenic Score Analysis Using Genome-Wide Association Data, P. A. F. Madden, A. C. Heath, M. L. Pergadia, A. Agrawal, P. Lin, R. A. Grucza, L. J. Bierut, Et Al

Open Access Publications

No abstract provided.


A Rapid Communication From The Aapm Task Group 201: Recommendations For The Qa Of External Beam Radiotherapy Data Transfer. Aapm Tg 201: Quality Assurance Of External Beam Radiotherapy Data Transfer, R. Alfredo Siochi, Peter Balter, Charles D. Bloch, Lakshmi Santanam, Kurt Blodgett, Bruce H. Curran, Martijn Engelsman, Wenzheng Feng, Jim Mechalakos, Dan Pavord, Tom Simon, Steven Sutlief, X. Ronald Zhu Jan 2011

A Rapid Communication From The Aapm Task Group 201: Recommendations For The Qa Of External Beam Radiotherapy Data Transfer. Aapm Tg 201: Quality Assurance Of External Beam Radiotherapy Data Transfer, R. Alfredo Siochi, Peter Balter, Charles D. Bloch, Lakshmi Santanam, Kurt Blodgett, Bruce H. Curran, Martijn Engelsman, Wenzheng Feng, Jim Mechalakos, Dan Pavord, Tom Simon, Steven Sutlief, X. Ronald Zhu

Open Access Publications

No abstract provided.


The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently Of The Interphotoreceptor Retinoid-Binding Protein, Alexander V. Kolesnikov, Peter H. Tang, Ryan O. Parker, Rosalie K. Crouch, Vladimir J. Kefalov Jan 2011

The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently Of The Interphotoreceptor Retinoid-Binding Protein, Alexander V. Kolesnikov, Peter H. Tang, Ryan O. Parker, Rosalie K. Crouch, Vladimir J. Kefalov

Open Access Publications

No abstract provided.


Implementation Of Whole Slide Imaging In Surgical Pathology: A Value Added Approach, Mike Isaacs, Jochen K. Lennerz, Stacey Yates, Walter Clermont, Joan Rossi, John D. Pfeifer Jan 2011

Implementation Of Whole Slide Imaging In Surgical Pathology: A Value Added Approach, Mike Isaacs, Jochen K. Lennerz, Stacey Yates, Walter Clermont, Joan Rossi, John D. Pfeifer

Open Access Publications

No abstract provided.


Opposing Synaptic Regulation Of Amyloid-Β Metabolism By Nmda Receptors In Vivo, Deborah K. Verges, Jessica L. Restivo, Whitney D. Goebel, David M. Holtzman, John R. Cirrito Jan 2011

Opposing Synaptic Regulation Of Amyloid-Β Metabolism By Nmda Receptors In Vivo, Deborah K. Verges, Jessica L. Restivo, Whitney D. Goebel, David M. Holtzman, John R. Cirrito

Open Access Publications

No abstract provided.


Lung Transplantation For Pulmonary Fibrosis In Dyskeratosis Congenita: Case Report And Systematic Literature Review, Neelam Giri, Rees Lee, Albert Faro, Charles B. Huddleston, Frances V. White, Blanche P. Alter, Sharon A. Savage Jan 2011

Lung Transplantation For Pulmonary Fibrosis In Dyskeratosis Congenita: Case Report And Systematic Literature Review, Neelam Giri, Rees Lee, Albert Faro, Charles B. Huddleston, Frances V. White, Blanche P. Alter, Sharon A. Savage

Open Access Publications

No abstract provided.


Evolving Diagnostic And Treatment Strategies For Pancreatic Neuroendocrine Tumors, Matthew H. Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier, James Yao Jan 2011

Evolving Diagnostic And Treatment Strategies For Pancreatic Neuroendocrine Tumors, Matthew H. Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier, James Yao

Open Access Publications

No abstract provided.


Correlation Of Cag Repeat Length Between The Maternal And Paternal Allele Of The Huntingtin Gene: Evidence For Assortative Mating, Peg Nopoulos, Eric A. Epping, Tom Wassink, Bradley L. Schlaggar, Joel Perlmutter Jan 2011

Correlation Of Cag Repeat Length Between The Maternal And Paternal Allele Of The Huntingtin Gene: Evidence For Assortative Mating, Peg Nopoulos, Eric A. Epping, Tom Wassink, Bradley L. Schlaggar, Joel Perlmutter

Open Access Publications

No abstract provided.


Genetic Incorporation Of Human Metallothionein Into The Adenovirus Protein Ix For Non-Invasive Spect Imaging, J. Michael Mathis, Shilpa Bhatia, Alok Khandelwal, Imre Kovesdi, Stephen J. Lokitz, Yoshi Odaka, Amol M. Takalkar, Tracee Terry, David T. Curiel Jan 2011

Genetic Incorporation Of Human Metallothionein Into The Adenovirus Protein Ix For Non-Invasive Spect Imaging, J. Michael Mathis, Shilpa Bhatia, Alok Khandelwal, Imre Kovesdi, Stephen J. Lokitz, Yoshi Odaka, Amol M. Takalkar, Tracee Terry, David T. Curiel

Open Access Publications

No abstract provided.


Mapping Human Cortical Areas In Vivo Based On Myelin Content As Revealed By T1- And T2-Weighted Mri, Matthew F. Glasser, David C. Van Essen Jan 2011

Mapping Human Cortical Areas In Vivo Based On Myelin Content As Revealed By T1- And T2-Weighted Mri, Matthew F. Glasser, David C. Van Essen

Open Access Publications

No abstract provided.


Haploinsufficiency Of Human Apoe Reduces Amyloid Deposition In A Mouse Model Of Amyloid-Β Amyloidosis, Jungsu Kim, Hong Jiang, Seonha Park, Adam E.M. Eltorai, Floy R. Stewart, Hyejin Yoon, Jacob M. Basak, Mary Beth Finn, David M. Holtzman Jan 2011

Haploinsufficiency Of Human Apoe Reduces Amyloid Deposition In A Mouse Model Of Amyloid-Β Amyloidosis, Jungsu Kim, Hong Jiang, Seonha Park, Adam E.M. Eltorai, Floy R. Stewart, Hyejin Yoon, Jacob M. Basak, Mary Beth Finn, David M. Holtzman

Open Access Publications

No abstract provided.