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Articles 4621 - 4650 of 6228
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Constitutive Activation Of Gli2 Impairs Bone Formation In Postnatal Growing Mice, Kyu Sang Joeng, Fanxin Long
Constitutive Activation Of Gli2 Impairs Bone Formation In Postnatal Growing Mice, Kyu Sang Joeng, Fanxin Long
Open Access Publications
No abstract provided.
Kinase Suppressor Of Ras 1 Is Not Required For The Generation Of Regulatory And Memory T Cells, Marie Le Borgne, Erin L. Filbert, Andrey S. Shaw
Kinase Suppressor Of Ras 1 Is Not Required For The Generation Of Regulatory And Memory T Cells, Marie Le Borgne, Erin L. Filbert, Andrey S. Shaw
Open Access Publications
No abstract provided.
Cerebellar White Matter Abnormalities Following Primary Blast Injury In Us Military Personnel, Christine Mac Donald, Ann Johnson, Dana Cooper, Thomas Malone, James Sorrell, Joshua Shimony, Matthew Parsons, Abraham Snyder, Marcus Raichel, Raymond Fang, Stephen Flaherty, Michael Russell, David L. Brody
Cerebellar White Matter Abnormalities Following Primary Blast Injury In Us Military Personnel, Christine Mac Donald, Ann Johnson, Dana Cooper, Thomas Malone, James Sorrell, Joshua Shimony, Matthew Parsons, Abraham Snyder, Marcus Raichel, Raymond Fang, Stephen Flaherty, Michael Russell, David L. Brody
Open Access Publications
No abstract provided.
Anatomical Segregation Of Visual Selection Mechanisms In Human Parietal Cortex, Paolo Capotosto, Annalisa Tosoni, Sara Spadone, Carlo Sestieri, Mauro Gianni Perrucci, Gian Luca Romani, Stefania Della Penna, Maurizio Corbetta
Anatomical Segregation Of Visual Selection Mechanisms In Human Parietal Cortex, Paolo Capotosto, Annalisa Tosoni, Sara Spadone, Carlo Sestieri, Mauro Gianni Perrucci, Gian Luca Romani, Stefania Della Penna, Maurizio Corbetta
Open Access Publications
No abstract provided.
Meniscal Repair Outcomes At Greater Than Five Years: A Systematic Literature Review And Meta-Analysis, Jeffrey J. Nepple, Warren R. Dunn, Rick W. Wright
Meniscal Repair Outcomes At Greater Than Five Years: A Systematic Literature Review And Meta-Analysis, Jeffrey J. Nepple, Warren R. Dunn, Rick W. Wright
Open Access Publications
No abstract provided.
Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond
Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond
Open Access Publications
No abstract provided.
Educating Medical Students In Musculoskeletal Surgery And Medicine: How To Get A Course Up And Running At Your Institution: Aoa Critical Issues, Charles S. Day, Joseph Bernstein, Martin I. Boyer
Educating Medical Students In Musculoskeletal Surgery And Medicine: How To Get A Course Up And Running At Your Institution: Aoa Critical Issues, Charles S. Day, Joseph Bernstein, Martin I. Boyer
Open Access Publications
No abstract provided.
The Influence Of Insurance Status On Access To And Utilization Of A Tertiary Hand Surgery Referral Center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, Charles A. Goldfarb
The Influence Of Insurance Status On Access To And Utilization Of A Tertiary Hand Surgery Referral Center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, Charles A. Goldfarb
Open Access Publications
No abstract provided.
2d Versus 3d Visualization: Impact On Laparoscopic Proficiency Using The Fundamentals Of Laparoscopic Surgery Skill Set, Youssef S. Tanagho, Gerald L. Andriole, Alethea G. Paradis, Kerry M. Madison, Gurdarshan S. Sandhu, J. Esteban Varela, Brian M. Benway
2d Versus 3d Visualization: Impact On Laparoscopic Proficiency Using The Fundamentals Of Laparoscopic Surgery Skill Set, Youssef S. Tanagho, Gerald L. Andriole, Alethea G. Paradis, Kerry M. Madison, Gurdarshan S. Sandhu, J. Esteban Varela, Brian M. Benway
Open Access Publications
No abstract provided.
Periacetabular Osteotomy And Combined Femoral Head-Neck Junction Osteochondroplasty: A Minimum Two-Year Follow-Up Cohort Study, Nader A. Nassif, Perry L. Schoenecker, Robert Thorsness, John C. Clohisy
Periacetabular Osteotomy And Combined Femoral Head-Neck Junction Osteochondroplasty: A Minimum Two-Year Follow-Up Cohort Study, Nader A. Nassif, Perry L. Schoenecker, Robert Thorsness, John C. Clohisy
Open Access Publications
No abstract provided.
Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry
Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry
Open Access Publications
Recording simultaneously from essentially all of the relevant neurons in a local circuit is crucial to understand how they collectively represent information. Here we show that the combination of a large, dense multielectrode array and a novel, mostly automated spike-sorting algorithm allowed us to record simultaneously from a highly overlapping population of >200 ganglion cells in the salamander retina. By combining these methods with labeling and imaging, we showed that up to 95% of the ganglion cells over the area of the array were recorded. By measuring the coverage of visual space by the receptive fields of the recorded cells, …
Protection Of Bone In Premenopausal Women With Breast Cancer: Focus On Zoledronic Acid, Rebecca Aft
Protection Of Bone In Premenopausal Women With Breast Cancer: Focus On Zoledronic Acid, Rebecca Aft
Open Access Publications
No abstract provided.
Off-Clamp Robot-Assisted Partial Nephrectomy: Initial Washington University Experience, Youssef S. Tanagho, Sam B. Bhayani, Eric H. Kim, Gurdarshan S. Sandhu, Nicolas P. Vaughn, R. Sherburne Figenshau
Off-Clamp Robot-Assisted Partial Nephrectomy: Initial Washington University Experience, Youssef S. Tanagho, Sam B. Bhayani, Eric H. Kim, Gurdarshan S. Sandhu, Nicolas P. Vaughn, R. Sherburne Figenshau
Open Access Publications
No abstract provided.
Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review, L. M. Kruse, B. Gray, R. W. Wright
Rehabilitation After Anterior Cruciate Ligament Reconstruction: A Systematic Review, L. M. Kruse, B. Gray, R. W. Wright
Open Access Publications
No abstract provided.
“Genomics And Translational Medicine For Information Professionals”: An Innovative Course To Educate The Next Generation Of Librarians, Ana D. Cleveland, Kristi L. Holmes, Jodi L. Philbrick
“Genomics And Translational Medicine For Information Professionals”: An Innovative Course To Educate The Next Generation Of Librarians, Ana D. Cleveland, Kristi L. Holmes, Jodi L. Philbrick
Open Access Publications
No abstract provided.
Off-Clamp Robot-Assisted Partial Nephrectomy For Complex Renal Tumors, Eric H. Kim, Youssef S. Tanagho, Gurdarshan Sandhu, Sam B. Bhayani, R. Sherburne Figenshau
Off-Clamp Robot-Assisted Partial Nephrectomy For Complex Renal Tumors, Eric H. Kim, Youssef S. Tanagho, Gurdarshan Sandhu, Sam B. Bhayani, R. Sherburne Figenshau
Open Access Publications
No abstract provided.
Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs
Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs
Open Access Publications
No abstract provided.
Antegrade Endoscopic Removal Of Retained Urethral Sling Mesh In The Bladder, Michael H. Johnson, Genoa G. Ferguson, Carl G. Klutke
Antegrade Endoscopic Removal Of Retained Urethral Sling Mesh In The Bladder, Michael H. Johnson, Genoa G. Ferguson, Carl G. Klutke
Open Access Publications
No abstract provided.
Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig
Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig
Open Access Publications
No abstract provided.
I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog
I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog
Open Access Publications
Neurons in the suprachiasmatic nucleus (SCN) display coordinated circadian changes in electrical activity that are critical for daily rhythms in physiology, metabolism, and behavior. SCN neurons depolarize spontaneously and fire repetitively during the day and hyperpolarize, drastically reducing firing rates, at night. To explore the hypothesis that rapidly activating and inactivating A-type (I(A)) voltage-gated K(+) (Kv) channels, which are also active at subthreshold membrane potentials, are critical regulators of the excitability of SCN neurons, we examined locomotor activity and SCN firing in mice lacking Kv1.4 (Kv1.4(-/-)), Kv4.2 (Kv4.2(-/-)), or Kv4.3 (Kv4.3(-/-)), the pore-forming (α) subunits of I(A) channels. Mice lacking …
Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow
Intermediate Outcomes Following Percutaneous Fixation Of Proximal Humeral Fractures, Alicia K. Harrison, Konrad I. Gruson, Benjamin Zmistowski, Jay Keener, Leesa Galatz, Gerald Williams, Bradford O. Parsons, Evan L. Flatgow
Open Access Publications
No abstract provided.
Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances
Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances
Open Access Publications
Alzheimer's disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in …
Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi
Diagnostic Performance And Reliability Of Ultrasonography For Fatty Degeneration Of The Rotator Cuff Muscles, Lindley B. Wall, Sharlene A. Teefey, William D. Middleton, Nirvikar Dahiya, Karen Steger-May, H. Mike Kim, Daniel Wessell, Ken Yamaguchi
Open Access Publications
No abstract provided.
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang
Open Access Publications
No abstract provided.
Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki
Detection Thresholds Of Macaque Otolith Afferents, Xiong-Jie Yu, J David Dickman, Dora E. Angelaki
Open Access Publications
The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored. Here we have used signal detection theory to measure detection thresholds of otolith afferents using 1 Hz linear accelerations delivered along three cardinal axes. Direction detection thresholds were measured by comparing mean firing rates centered on response peak and trough (full-cycle thresholds) or by comparing peak/trough firing rates with spontaneous activity (half-cycle thresholds). Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, and vertical motion directions. When computed …
Multi-Institutional Analysis Of Robot-Assisted Partial Nephrectomy For Renal Tumors >4 Cm Versus ≤4 Cm In 445 Consecutive Patients, Firas Petros, Shyam Sukumar, Georges-Pascal Haber, Lori Dulabon, Sam Bhayani, Michael Stifelman, Jihad Kaouk, Craig Rogers
Multi-Institutional Analysis Of Robot-Assisted Partial Nephrectomy For Renal Tumors >4 Cm Versus ≤4 Cm In 445 Consecutive Patients, Firas Petros, Shyam Sukumar, Georges-Pascal Haber, Lori Dulabon, Sam Bhayani, Michael Stifelman, Jihad Kaouk, Craig Rogers
Open Access Publications
No abstract provided.
Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein
Vascular Anatomy Of The Tibiofibular Syndesmosis, Kathleen E. Mckeon, Rick W. Wright, Jeffrey E. Johnson, Jeremy J. Mccormick, Sandra E. Klein
Open Access Publications
No abstract provided.
Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick
Synaptic Nmda Receptors Mediate Hypoxic Excitotoxic Death, Christine M. Wroge, Joshua Hogins, Larry Eisenman, Steven Mennerick
Open Access Publications
Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia. Thus, the development of effective therapeutics for these disorders demands a complete understanding of NMDA receptor (NMDAR) activation during excitotoxic insults. The extrasynaptic NMDAR hypothesis posits that synaptic NMDARs are neurotrophic/neuroprotective and extrasynaptic NMDARs are neurotoxic. The extrasynaptic hypothesis is built in part on observed selectivity for extrasynaptic receptors of a neuroprotective use-dependent NMDAR channel blocker, memantine. In rat hippocampal neurons, we found that a neuroprotective concentration of memantine shows little selectivity for extrasynaptic NMDARs when all receptors are tonically activated by exogenous glutamate. …
Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo
Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo
Open Access Publications
No abstract provided.
A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio
A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio
Open Access Publications
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of chemotherapy drugs. Molecules that promote axonal degeneration could represent potential targets for therapy. To identify such molecules, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol), a chemotherapeutic agent that causes neuropathy in cancer patients. In Drosophila, taxol treatment causes swelling, fragmentation, and loss of axons in larval peripheral nerves. This axonal loss is not due to apoptosis of neurons. Taxol-induced axonal degeneration …